Michal Or-Guil

Summary

Affiliation: Humboldt University
Country: Germany

Publications

  1. pmc How oligoclonal are germinal centers? A new method for estimating clonal diversity from immunohistological sections
    Jose Faro
    Department of Biochemistry, Genetics and Immunology, University of Vigo, Vigo, Spain
    BMC Bioinformatics 14:S8. 2013
  2. ncbi request reprint Recirculation of germinal center B cells: a multilevel selection strategy for antibody maturation
    Michal Or-Guil
    Systems Immunology Group, Institute for Theoretical Biology, Humboldt University, Berlin, Germany
    Immunol Rev 216:130-41. 2007
  3. doi request reprint Is there a typical germinal center? A large-scale immunohistological study on the cellular composition of germinal centers during the hapten-carrier-driven primary immune response in mice
    Nicole Wittenbrink
    Systems Immunology Laboratory, Department of Biology, Humboldt University Berlin, D 10115 Berlin, Germany
    J Immunol 187:6185-96. 2011
  4. doi request reprint Epitope mapping using randomly generated peptide libraries
    Juliane Bongartz
    Systems Immunology Group, Institute for Theoretical Biology, Humboldt University Berlin, Invalidenstr, 43, 10115 Berlin, Germany
    Methods Mol Biol 524:237-46. 2009
  5. doi request reprint Broad volume distributions indicate nonsynchronized growth and suggest sudden collapses of germinal center B cell populations
    Nicole Wittenbrink
    Systems Immunology Group, Institute for Theoretical Biology, Humboldt University Berlin, Germany
    J Immunol 184:1339-47. 2010
  6. pmc A minimal model of peptide binding predicts ensemble properties of serum antibodies
    Victor Greiff
    Systems Immunology Lab, Department of Biology, Humboldt University Berlin, and Research Center ImmunoSciences, Charite University Medicine Berlin, Berlin, Germany
    BMC Genomics 13:79. 2012
  7. doi request reprint Affinity maturation of B cells involves not only a few but a whole spectrum of relevant mutations
    Armin A Weiser
    Systems Immunology Lab, Department of Biology, Institute for Theoretical Biology, Humboldt University, Invalidenstrasse 43, 10115 Berlin, Germany
    Int Immunol 23:345-56. 2011
  8. ncbi request reprint Affinity profiling using the peptide microarray technology: a case study
    Victor Tapia
    Institute for Theoretical Biology, Humboldt University, Invalidenstrasse 43, 10115 Berlin, Germany
    Anal Biochem 363:108-18. 2007

Collaborators

Detail Information

Publications8

  1. pmc How oligoclonal are germinal centers? A new method for estimating clonal diversity from immunohistological sections
    Jose Faro
    Department of Biochemistry, Genetics and Immunology, University of Vigo, Vigo, Spain
    BMC Bioinformatics 14:S8. 2013
    ..Based on a simple model, investigators concluded that a typical GC was seeded by 2-8 B cells, endorsing the current notion that GCs are oligoclonal from the onset...
  2. ncbi request reprint Recirculation of germinal center B cells: a multilevel selection strategy for antibody maturation
    Michal Or-Guil
    Systems Immunology Group, Institute for Theoretical Biology, Humboldt University, Berlin, Germany
    Immunol Rev 216:130-41. 2007
    ..The concepts of iteration, all-or-none behavior, and phasic mutation schedule are discussed in the light of this hypothesis...
  3. doi request reprint Is there a typical germinal center? A large-scale immunohistological study on the cellular composition of germinal centers during the hapten-carrier-driven primary immune response in mice
    Nicole Wittenbrink
    Systems Immunology Laboratory, Department of Biology, Humboldt University Berlin, D 10115 Berlin, Germany
    J Immunol 187:6185-96. 2011
    ..DZ and LZ differ in the T cell-to-macrophage ratio rather than in the density of T cells...
  4. doi request reprint Epitope mapping using randomly generated peptide libraries
    Juliane Bongartz
    Systems Immunology Group, Institute for Theoretical Biology, Humboldt University Berlin, Invalidenstr, 43, 10115 Berlin, Germany
    Methods Mol Biol 524:237-46. 2009
    ....
  5. doi request reprint Broad volume distributions indicate nonsynchronized growth and suggest sudden collapses of germinal center B cell populations
    Nicole Wittenbrink
    Systems Immunology Group, Institute for Theoretical Biology, Humboldt University Berlin, Germany
    J Immunol 184:1339-47. 2010
    ..Possible causes of GC B cell population collapses are discussed in the context of the affinity-maturation process...
  6. pmc A minimal model of peptide binding predicts ensemble properties of serum antibodies
    Victor Greiff
    Systems Immunology Lab, Department of Biology, Humboldt University Berlin, and Research Center ImmunoSciences, Charite University Medicine Berlin, Berlin, Germany
    BMC Genomics 13:79. 2012
    ..We analyzed the resulting antibody binding profiles with regression methods and formulated a minimal model to explain our findings...
  7. doi request reprint Affinity maturation of B cells involves not only a few but a whole spectrum of relevant mutations
    Armin A Weiser
    Systems Immunology Lab, Department of Biology, Institute for Theoretical Biology, Humboldt University, Invalidenstrasse 43, 10115 Berlin, Germany
    Int Immunol 23:345-56. 2011
    ..Moreover, our results suggest that maturation not only involves selection by means of affinity but likewise expression and stabilization of BCRs...
  8. ncbi request reprint Affinity profiling using the peptide microarray technology: a case study
    Victor Tapia
    Institute for Theoretical Biology, Humboldt University, Invalidenstrasse 43, 10115 Berlin, Germany
    Anal Biochem 363:108-18. 2007
    ..The experimental requirements needed to obtain reliable binding affinity predictions are discussed...