Affiliation: Humboldt University
MÃ¼ller Redetzky H, Felten M, Hellwig K, Wienhold S, Naujoks J, Opitz B, et al
. Increasing the inspiratory time and I:E ratio during mechanical ventilation aggravates ventilator-induced lung injury in mice. Crit Care. 2015;19:23 pubmed publisher
..Thus increasing the inspiratory time and I:E ratio should be critically considered. ..
Rabes A, Suttorp N, Opitz B. Inflammasomes in Pneumococcal Infection: Innate Immune Sensing and Bacterial Evasion Strategies. Curr Top Microbiol Immunol. 2016;397:215-27 pubmed publisher
..pneumoniae-induced cellular perturbations, summarize their role in pneumococcal infections, and discuss potential evasion strategies of some emerging pneumococcal strains. ..
Ruiz Moreno J, Hamann L, Jin L, Sander L, Puzianowska Kuznicka M, Cambier J, et al
. The cGAS/STING Pathway Detects Streptococcus pneumoniae but Appears Dispensable for Antipneumococcal Defense in Mice and Humans. Infect Immun. 2018;86: pubmed publisher
..Together, our results indicate that the cGAS/STING pathway senses S. pneumoniae but plays no major role in antipneumococcal immunity in mice and humans. ..
Opitz B, Vinzing M, van Laak V, Schmeck B, Heine G, Günther S, et al
. Legionella pneumophila induces IFNbeta in lung epithelial cells via IPS-1 and IRF3, which also control bacterial replication. J Biol Chem. 2006;281:36173-9 pubmed
..pneumophila in lung epithelial cells. In conclusion, we demonstrated a critical role of IPS-1, IRF3, and IFNbeta in Legionella infection of lung epithelium. ..
Opitz B, van Laak V, Eitel J, Suttorp N. Innate immune recognition in infectious and noninfectious diseases of the lung. Am J Respir Crit Care Med. 2010;181:1294-309 pubmed publisher
..The PRRs and their signaling pathways represent promising targets for prophylactic and therapeutic interventions in various lung diseases. ..
Naujoks J, Lippmann J, Suttorp N, Opitz B. Innate sensing and cell-autonomous resistance pathways in Legionella pneumophila infection. Int J Med Microbiol. 2017;: pubmed publisher
..This article summarizes the current knowledge of innate immune responses to L. pneumophila infection in general, and of macrophage-intrinsic defense mechanisms in particular...