M Obladen

Summary

Affiliation: Humboldt University
Country: Germany

Publications

  1. ncbi Maturation-dependent oligodendrocyte apoptosis caused by hyperoxia
    Bettina Gerstner
    Department of Neonatology, Charite Campus Virchow Klinikum, Berlin, Germany
    J Neurosci Res 84:306-15. 2006
  2. ncbi Hematologic effects of maternal antiretroviral therapy and transmission prophylaxis in HIV-1-exposed uninfected newborn infants
    Cornelia Feiterna-Sperling
    Charite, Department of Pediatric Pneumology and Immunology, University Medicine Berlin, Berlin, Germany
    J Acquir Immune Defic Syndr 45:43-51. 2007
  3. ncbi Regulated wet nursing: managed care or organized crime?
    Michael Obladen
    Department of Neonatology, Charite University Medicine, Berlin, Germany
    Neonatology 102:222-8. 2012
  4. doi Curse on two generations: a history of congenital syphilis
    Michael Obladen
    Department of Neonatology, Charite University Medicine, Berlin, Germany
    Neonatology 103:274-80. 2013
  5. doi In God's image? The tradition of infant head shaping
    Michael Obladen
    Department of Neonatology, Charite University Medicine Berlin, Berlin, Germany
    J Child Neurol 27:672-80. 2012
  6. pmc Preconceptional factors associated with very low birthweight delivery in East and West Berlin: a case control study
    Ingrid Grimmer
    Department of Neonatology, Charité Virchow Hospital Humboldt University, Berlin, Germany
    BMC Public Health 2:10. 2002
  7. pmc Elevated nerve growth factor and neurotrophin-3 levels in cerebrospinal fluid of children with hydrocephalus
    F Hochhaus
    Neonatology, Charite, Campus Virchow Klinikum, Humboldt University, Berlin, Germany
    BMC Pediatr 1:2. 2001
  8. doi Historical notes on immaturity. Part 1: measures of viability
    Michael Obladen
    Department of Neonatology, Charite University Medicine, Berlin, Germany
    J Perinat Med 39:563-9. 2011
  9. ncbi [Minimum patient volume in care for very low birthweight infants: a review of the literature]
    M Obladen
    Klinik für Neonatologie, Charite Universitatsmedizin Berlin, Charite Virchow Klinikum, Augustenburger Platz 1, 13353 Berlin
    Z Geburtshilfe Neonatol 211:110-7. 2007
  10. doi From monster to twin reversed arterial perfusion: a history of acardiac twins
    Michael Obladen
    Department of Neonatology, Charite University Medicine, Berlin, Germany
    J Perinat Med 38:247-53. 2010

Detail Information

Publications98

  1. ncbi Maturation-dependent oligodendrocyte apoptosis caused by hyperoxia
    Bettina Gerstner
    Department of Neonatology, Charite Campus Virchow Klinikum, Berlin, Germany
    J Neurosci Res 84:306-15. 2006
    ..Hyperoxia triggers maturation-dependent apoptosis in immature and pre-OLs and involves caspase activation. This mechanism may be relevant to the white matter injury observed in infants born preterm...
  2. ncbi Hematologic effects of maternal antiretroviral therapy and transmission prophylaxis in HIV-1-exposed uninfected newborn infants
    Cornelia Feiterna-Sperling
    Charite, Department of Pediatric Pneumology and Immunology, University Medicine Berlin, Berlin, Germany
    J Acquir Immune Defic Syndr 45:43-51. 2007
    ..A prospective observational study to investigate hematologic alterations during the first 3 months of life in HIV-exposed uninfected infants subjected to antiretroviral medication before and after birth...
  3. ncbi Regulated wet nursing: managed care or organized crime?
    Michael Obladen
    Department of Neonatology, Charite University Medicine, Berlin, Germany
    Neonatology 102:222-8. 2012
    ..When artificial feeding lost its threat thanks to sewage disposal, improved plumbing, the introduction of rubber teats, cooling facilities and commercial formula, wet nursing declined towards the end of the 19th century...
  4. doi Curse on two generations: a history of congenital syphilis
    Michael Obladen
    Department of Neonatology, Charite University Medicine, Berlin, Germany
    Neonatology 103:274-80. 2013
    ..In 1943, Lentz and Ingraham established penicillin treatment for congenital syphilis. Whereas this drug effectively prevented maternofetal transmission, treating infants remained difficult due to the Jarisch-Herxheimer reaction...
  5. doi In God's image? The tradition of infant head shaping
    Michael Obladen
    Department of Neonatology, Charite University Medicine Berlin, Berlin, Germany
    J Child Neurol 27:672-80. 2012
    ..With the advent of positional plagiocephaly following the back-to-sleep campaign, head shaping has regained acceptance and is now being widely used again...
  6. pmc Preconceptional factors associated with very low birthweight delivery in East and West Berlin: a case control study
    Ingrid Grimmer
    Department of Neonatology, Charité Virchow Hospital Humboldt University, Berlin, Germany
    BMC Public Health 2:10. 2002
    ..Despite the growing body of evidence linking sociodemographic variables with preterm delivery, little is known as to how this may be extrapolated to the risk of very low birthweight...
  7. pmc Elevated nerve growth factor and neurotrophin-3 levels in cerebrospinal fluid of children with hydrocephalus
    F Hochhaus
    Neonatology, Charite, Campus Virchow Klinikum, Humboldt University, Berlin, Germany
    BMC Pediatr 1:2. 2001
    ..We investigated whether concentrations of NGF and NT-3 are increased in the CSF of children with hydrocephalus...
  8. doi Historical notes on immaturity. Part 1: measures of viability
    Michael Obladen
    Department of Neonatology, Charite University Medicine, Berlin, Germany
    J Perinat Med 39:563-9. 2011
    ..The idea of viability is a remnant of vitalism, a medical doctrine popularized in 1780 by Brown. Many short-lived statements defined its limit, but until now what was meant by viability remained nebulous...
  9. ncbi [Minimum patient volume in care for very low birthweight infants: a review of the literature]
    M Obladen
    Klinik für Neonatologie, Charite Universitatsmedizin Berlin, Charite Virchow Klinikum, Augustenburger Platz 1, 13353 Berlin
    Z Geburtshilfe Neonatol 211:110-7. 2007
    ..The question arises if the formation of a great number of small NICUs compromises the outcome of infants with less than 1 500 g birthweight (VLBW)...
  10. doi From monster to twin reversed arterial perfusion: a history of acardiac twins
    Michael Obladen
    Department of Neonatology, Charite University Medicine, Berlin, Germany
    J Perinat Med 38:247-53. 2010
    ..Today, it is assumed that both mechanisms may exist. With the advent of prenatal ultrasound diagnosis and radiofrequency ablation of the acardiac twin's circulation, it became possible to save the pump twin...
  11. doi Much ado about nothing: two millenia of controversy on tongue-tie
    Michael Obladen
    Department of Neonatology, Charite University Medicine, Berlin, Germany
    Neonatology 97:83-9. 2010
    ..Despite the high frequency of the intervention, little research has been performed on its benefit, which remains a controversial topic among different groups of health professionals...
  12. doi Necrotizing enterocolitis--150 years of fruitless search for the cause
    Michael Obladen
    Department of Neonatology, Charite University Medicine, Berlin, Germany
    Neonatology 96:203-10. 2009
    ..The pathogenesis remains unclear and its distinction from related disorders uncertain. It is unlikely that strategies to prevent NEC will be successful unless the disease is better understood...
  13. doi History of neonatal resuscitation - part 3: endotracheal intubation
    Michael Obladen
    Department of Neonatology, Charite University Medicine, Berlin, Germany
    Neonatology 95:198-202. 2009
    ..The striking absence of scientific studies on the most efficient resuscitation techniques for neonates can be explained by the difficulty to adjust for the personal skills of the resuscitator...
  14. doi History of neonatal resuscitation. Part 2: oxygen and other drugs
    Michael Obladen
    Department of Neonatology, Charite University Medicine, Berlin, Germany
    Neonatology 95:91-6. 2009
    ..Continuous distending airway pressure for oxygen administration was available at the beginning of the 20th century, but was not widely accepted. Alkali and analeptic drugs gained widespread but short-lived use after the Second World War...
  15. doi History of neonatal resuscitation. Part 1: Artificial ventilation
    Michael Obladen
    Department of Neonatology, Charite University Medicine, Berlin, Germany
    Neonatology 94:144-9. 2008
    ..Indirect techniques like that of Silvester or the Schultze swingings gained widespread acceptance and prevailed until the First World War. Modern ventilators were developed following the poliomyelitis epidemics in the 20th century...
  16. doi Low Apgar score without acidosis may indicate neuromuscular disorder
    Michael Obladen
    Department of Neonatology, Charite University Medicine, Campus Virchow Klinikum, Berlin, Germany
    Early Hum Dev 84:673-9. 2008
    ..We hypothesized that in term infants low Apgar score with normal umbilical artery pH (UApH) indicates prenatal damage to the neuromuscular system...
  17. doi Interdisciplinary surveillance of intraventricular haemorrhage associated conditions in infants <1000 g
    Michael Obladen
    Department of Neonatology, Charite Berlin, Berlin, Germany
    Acta Paediatr 97:731-7. 2008
    ..We hypothesized that prospective surveillance of these IVH-associated conditions decreases their frequency and thus the frequency of IVH...
  18. doi History of the ductus arteriosus: 1. Anatomy and spontaneous closure
    Michael Obladen
    Department of Neonatology, Charite University Medicine, Berlin, Germany
    Neonatology 99:83-9. 2011
    ..After the discovery of prostaglandins by Bergstrom and Vane, Coceani proved that ductal patency is maintained by the relaxant action of prostaglandins...
  19. doi History of the ductus arteriosus: 2. Persisting patency in the preterm infant
    Michael Obladen
    Department of Neonatology, Charite University Medicine, Berlin, Germany
    Neonatology 99:163-9. 2011
    ..This series of events exemplifies how clinical research became an integrated managed multidisciplinary endeavor in the 20th century...
  20. ncbi History of surfactant up to 1980
    Michael Obladen
    Department of Neonatology, Charite University Medicine, Campus Virchow Klinikum, Berlin, Germany
    Biol Neonate 87:308-16. 2005
    ..A century of basic research was rewarded when Fujiwara introduced surfactant substitution in Japan in 1980 for treatment and prevention of RDS...
  21. ncbi Venous and arterial hematologic profiles of very low birth weight infants. European Multicenter rhEPO Study Group
    M Obladen
    Department of Neonatology, Charite Virchow Hospital, Berlin, Germany
    Pediatrics 106:707-11. 2000
    ..In very low birth weight (VLBW) infants, diagnostic and therapeutic decisions depend on hematologic values. As few data are available, we studied the course during the first 6 weeks of life...
  22. doi Unequal but monozygous: a history of twin-twin transfusion syndrome
    Michael Obladen
    Department of Neonatology, Charite University Medicine, Berlin, Germany
    J Perinat Med 38:121-8. 2010
    ..With the advent of ultrasound and laser techniques, prenatal diagnosis and treatment became available in the last decade of the 20(th) century...
  23. doi Cats, frogs, and snakes: early concepts of neural tube defects
    Michael Obladen
    Department of Neonatology, Charite University Medicine, Berlin, Germany
    J Child Neurol 26:1452-61. 2011
    ..The mandatory supplementation of folate in staple foods successfully reduced the incidence of neural tube defects in the United States, Australia, Canada, and Chile, but it was not adopted by most European countries...
  24. ncbi Thrombopoietin concentration in umbilical cord blood of healthy term newborns is higher than in adult controls
    M M Walka
    Department of Neonatology, Virchow Hospital, Humboldt University, Berlin, Germany
    Biol Neonate 75:54-8. 1999
    ..95th percentile was 255 pg/ml. In only 8% (10/121), TPO was below the detection limit compared to 81% of healthy adults (25/31). In cord blood and adult controls, there were no significant correlations of TPO with platelet count or mass...
  25. doi Historical notes on immaturity. Part 2: surviving against the odds
    Michael Obladen
    Department of Neonatology, Charite University Medicine, Berlin, Germany
    J Perinat Med 39:571-7. 2011
    ..Instead of assessing an infant's individual prognosis, and ignoring its gender, co-morbidities, and particular cause of premature delivery, these rules frequently relied on gestational age alone to initiate or withhold life support...
  26. doi Lame from birth: early concepts of cerebral palsy
    Michael Obladen
    Department of Neonatology, Charite University Medicine Berlin, Berlin, Germany
    J Child Neurol 26:248-56. 2011
    ..Although a causal relationship of cerebral palsy to the birth never has been established, the habit to put the blame for cerebral palsy on someone remained a frequent attitude...
  27. doi Neurodevelopmental outcome after COX inhibitor treatment for patent ductus arteriosus
    C Rheinlaender
    Department of Neonatology, Charite, Universitatsmedizin Berlin, Campus Virchow Klinikum, Germany
    Early Hum Dev 86:87-92. 2010
    ....
  28. ncbi Fas (CD95/Apo-1)/Fas ligand expression in neonates with pontosubicular neuron necrosis
    Frank K H van Landeghem
    Institute of Neuropathology, Charite, Campus Virchow Klinikum, Humboldt University, Augustenburger Platz 1, D 13353 Berlin, Germany
    Pediatr Res 51:129-35. 2002
    ..There was no significant difference between cases with and without PSN. We conclude that in the developing human brain, cells expressing the Fas receptor may be susceptible to undergoing apoptosis in response to hypoxic-ischemic injury...
  29. ncbi Neuronal damage after moderate hypoxia and erythropoietin
    Astrid Weber
    Department of Neonatology, Campus Virchow Klinikum, Berlin, Germany
    Neurobiol Dis 20:594-600. 2005
    ..Thus, erythropoietin may aggravate rather than ameliorate neuronal damage when administered during transient hypoxia...
  30. ncbi Breast milk from mothers of very low birthweight infants: variability in fat and protein content
    A Weber
    Department of Neonatology, Charite Virchow Hospital, Humboldt University, Berlin, Germany
    Acta Paediatr 90:772-5. 2001
    ..001). Protein but not fat content decreased during the weeks of lactation (rs =-0.446, p < 0.001). No impact of the baby's gestational age was observed...
  31. ncbi Early cessation of breast milk feeding in very low birthweight infants
    B Killersreiter
    Department of Neonatology, , Humboldt University, Berlin, Germany
    Early Hum Dev 60:193-205. 2001
    ....
  32. ncbi Low soluble Fas (sFas) and sFas ligand (sFasL) content in breast milk after preterm as opposed to term delivery
    F Jochum
    Department of Neonatology, Virchow Hospital, Charite, Berlin, Germany
    Acta Paediatr 94:143-6. 2005
    ..Assuming that sFas and sFasL in milk reflect cellular events during lactogenesis, we aimed to assess the impact of premature parturition and duration of lactation on the concentrations of sFas and sFasL in human milk...
  33. doi Growth in high risk infants <1500 g birthweight during the first 5 weeks
    A Loui
    Department of Neonatology, Charite Virchow Hospital, Humboldt University, Berlin, Germany
    Early Hum Dev 84:645-50. 2008
    ..Growth of very low birthweight (VLBW) infants is used to monitor nutrition and intrauterine velocity is taken as the desired goal...
  34. ncbi The CRIB (Clinical Risk Index for Babies) score and neurodevelopmental impairment at one year corrected age in very low birth weight infants
    C Buhrer
    Department of Neonatology, Charite Virchow Hospital, Humboldt University, Berlin, Germany
    Intensive Care Med 26:325-9. 2000
    ..To assess the ability of the Clinical Risk Index for Babies (CRIB) to predict long-term neurodevelopmental impairment in very low birth weight (VLBW) infants...
  35. pmc Increased cerebrospinal fluid concentrations of soluble Fas (CD95/Apo-1) in hydrocephalus
    U Felderhoff-Mueser
    Department of Neonatology, Charite Children s Hospital, Virchow Klinikum, Humboldt University, Augustenburger Platz 1, 13353 Berlin, Germany
    Arch Dis Child 84:369-72. 2001
    ..One of the regulators of the apoptotic cell death programme is the receptor mediated Fas/Fas ligand interaction...
  36. ncbi Patent ductus arteriosus in very low birthweight infants: complications of pharmacological and surgical treatment
    P S Koehne
    Departments of Neonatology and Pediatric Cardiology, Charite Virchow Hospital, Humboldt University, Department of Cardiovascular Surgery, German Heart Institute Berlin, Germany
    J Perinat Med 29:327-34. 2001
    ..To evaluate complications of surgical and pharmacological treatment of symptomatic patent ductus arteriosus (PDA) in very low birthweight (VLBW) infants...
  37. doi CRIB, CRIB-II, birth weight or gestational age to assess mortality risk in very low birth weight infants?
    Christoph Buhrer
    Department of Neonatology, Charite University Medical Center, Campus Virchow Klinikum, Berlin, Germany
    Acta Paediatr 97:899-903. 2008
    ..This analysis compared the power of CRIB, CRIB-II, birth weight and gestational age to predict death prior to discharge...
  38. ncbi Hypoxia-induced cell death and changes in hypoxia-inducible factor-1 activity in PC12 cells upon exposure to nerve growth factor
    Nico Charlier
    Department of Neonatology, Charite, Humboldt University, 14057, Berlin, Germany
    Brain Res Mol Brain Res 104:21-30. 2002
    ..The decrease in HIF-1 activity and the increase in hypoxia sensitivity may suggest that NGF act as an hierarchically organized signaling molecule...
  39. ncbi 3-D sonographic volume measurement of the cerebral ventricular system: in vitro validation
    W Kampmann
    Department of Neonatology, Charite, Virchow Hospital, Humboldt Universitat Berlin, Germany
    Ultrasound Med Biol 24:1169-74. 1998
    ..6% to 10.8% for complete investigation, and 0.6% to 1.6% for the marking process. We conclude that 3-D freehand ultrasonography may be useful for examining ventricle dilatation in infancy...
  40. ncbi Selenium status in term and preterm infants during the first months of life
    A Loui
    Department of Neonatology, Charite Virchow Hospital, Humboldt University, Berlin, Germany
    Eur J Clin Nutr 62:349-55. 2008
    ..We hypothesized that very low birth weight (VLBW) infants have reduced serum and red blood cell (RBC) selenium (Se) at birth, which decrease further with current nutrition and are associated with chronic lung disease and septicaemia...
  41. ncbi Nutritional zinc balance in extremely low-birth-weight infants
    A Loui
    Department of Neonatology, Charite Virchow Hospital, Humboldt University Berlin, Germany
    J Pediatr Gastroenterol Nutr 32:438-42. 2001
    ..The authors performed nutritional balances in 10 infants with birth weights of 500 to 999 g and who were fed with fortified human milk...
  42. ncbi Acute neuronal injury after hypoxia is influenced by the reoxygenation mode in juvenile hippocampal slice cultures
    Johannes Graulich
    Charite, Humboldt University Berlin, Department of Neonatology, Augustenburger Platz 1, D 13353 Berlin, Germany
    Brain Res Dev Brain Res 137:35-42. 2002
    ..In conclusion, juvenile hippocampal slice cultures subjected to hyperoxic reoxygenation display a greater amount of acute neuronal injury than slice cultures undergoing normoxic reoxygenation...
  43. ncbi High thrombopoietin concentrations in the cerebrospinal fluid of neonates with sepsis and intraventricular hemorrhage may contribute to brain damage
    Anke Reinhold
    Department of Neonatology, Campus Virchow Klinikum, Charite Universitatsmedizin Berlin, D 13353 Berlin, Germany
    J Interferon Cytokine Res 27:137-45. 2007
    ..In conclusion, our data provide evidence that in neuronal cells, TPO production is regulated by different mechanisms than in hepatocytes...
  44. ncbi 3-D ultrasound quantification of neonatal cerebral ventricles in different head positions
    N Nagdyman
    Department of Neonatology, Charite Virchow Hospital, Humboldt University, Berlin, Germany
    Ultrasound Med Biol 25:895-900. 1999
    ..01). Freehand 3-D US allows quantification of small volumes as neonatal lateral cerebral ventricles. Head position influences the lateral cerebral ventricle volume in low-birth-weight infants...
  45. ncbi Hyperoxia- and hypoxia-mediated activation of polymorphonuclear leukocytes: a comparison of cord and adult venous blood
    T Hoehn
    Department of Neonatology, Humboldt University, Charite, Campus Virchow Hospital, Augustenburger Platz 1, 13353, Berlin, Germany
    Resuscitation 51:63-8. 2001
    ..This increase is even more pronounced in neonatal resuscitation using 100% oxygen, currently recommended in the published guidelines...
  46. pmc Staphylococcal scalded-skin syndrome complicating wound infection in a preterm infant with postoperative chylothorax
    B Peters
    Department of Neonatology, Charite Virchow Hospital, Humbold University, Berlin, Germany
    J Clin Microbiol 36:3057-9. 1998
    ..In this case, prematurity and loss of chylus with consecutive lymphopenia may have contributed to development of SSSS...
  47. pmc Acidosis activates complement system in vitro
    M Emeis
    Department of Neonatology, , Virchow Hospital, Humboldt University Berlin, Germany
    Mediators Inflamm 7:417-20. 1998
    ..37. In this respiratory compensated metabolic acidosis, C3a and C5a were not increased. These experiments show that acidosis itself and not lactate trigger for activation of complement components C3 and C5...
  48. ncbi Calcium, phosphorus and magnesium balance: FM 85 fortification of human milk does not meet mineral needs of extremely low birthweight infants
    A Loui
    Department of Neonatology, Charite Virchow Hospital, Humboldt University Berlin, Germany
    Eur J Clin Nutr 56:228-35. 2002
    ..Extremely low birthweight (<1000 g) infants are growing rapidly and their nutritional requirements for calcium, phosphorus, magnesium are high...
  49. ncbi Early biochemical indicators of hypoxic-ischemic encephalopathy after birth asphyxia
    N Nagdyman
    Department of Neonatology, Institute of Laboratory Medicine, Charite University Hospital, Humboldt University Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
    Pediatr Res 49:502-6. 2001
    ..We conclude that elevated serum concentrations of protein S-100 and CK-BB reliably indicate moderate and severe HIE as early as 2 h after birth...
  50. doi Resolution of human immunodeficiency virus type 1 infection-related severe pulmonary hypertension in a very low-birth-weight infant
    Cornelia Feiterna-Sperling
    Department of Pediatric Pneumology, Charite, University Medicine Berlin, Berlin, Germany
    Pediatr Infect Dis J 27:564-7. 2008
    ..Here, we report the case of a preterm infant with HIV-related life-threatening PAH, which resolved after initiation of highly active antiretroviral therapy...
  51. ncbi Soluble Fas (CD95/Apo-1), soluble Fas ligand, and activated caspase 3 in the cerebrospinal fluid of infants with posthemorrhagic and nonhemorrhagic hydrocephalus
    Ursula Felderhoff-Mueser
    Department of Neonatology, Charite, Children s Hospital, Campus Virchow Klinikum, D 13353 Berlin, Germany
    Pediatr Res 54:659-64. 2003
    ..Increased intrathecal release of sFas in the cerebrospinal fluid of infants with hydrocephalus may serve as an indicator of brain injury from progressive ventricular dilatation...
  52. ncbi Predictive value of brain-specific proteins in serum for neurodevelopmental outcome after birth asphyxia
    Nicole Nagdyman
    Department of Neonatology, Charité Virchow University Hospital, Humboldt University Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
    Pediatr Res 54:270-5. 2003
    ..We conclude that serum protein S-100beta, NSE, and CK-BB, sampled on the first day of life, is of limited value in predicting severe brain damage after birth asphyxia...
  53. doi 17beta-estradiol attenuates hyperoxia-induced apoptosis in mouse C8-D1A cell line
    Stephanie Huppmann
    Department of Neonatology, Charite, Campus Virchow Klinikum, Berlin, Germany
    J Neurosci Res 86:3420-6. 2008
    ..Hyperoxia induces apoptosis in C8-D1A cells, and E2 seems to be a protecting factor for astrocytes in hyperoxia. This effect is not mediated through up-regulation of pERK1/2...
  54. ncbi Severe spinal muscular atrophy variant associated with congenital bone fractures
    Ursula Felderhoff-Mueser
    Department of Neonatology, Humboldt University, Berlin, Germany
    J Child Neurol 17:718-21. 2002
    ..We present clinical, molecular, and autopsy findings of a newborn boy presenting with generalized muscular atrophy in combination with congenital bone fractures and extremely thin ribs but without contractures...
  55. ncbi Erythropoietin improves synaptic transmission during and following ischemia in rat hippocampal slice cultures
    Astrid Weber
    Department of Neonatology, Charite, Humboldt University Berlin, Campus Virchow Klinikum, Augustenburger Platz 1, D 13353 Berlin, Germany
    Brain Res 958:305-11. 2002
    ..The addition of the Jak2 inhibitor AG490 (50 microM for 48 h) blocked the EPO effect. These data suggest that EPO improves synaptic transmission during and following ischemia in hippocampal slice cultures...
  56. ncbi A comparison of two mortality risk scores for very low birthweight infants: clinical risk index for babies and Berlin score
    Rolf F Maier
    Department of Neonatology, Charite Campus Virchow Klinikum, Humboldt Universitat, Augustenburger Platz 1, 13353 Berlin, Germany
    Intensive Care Med 28:1332-5. 2002
    ..To compare the performance of two mortality risk scores for very low birthweight (VLBW) infants...
  57. doi A critical role for Fas/CD-95 dependent signaling pathways in the pathogenesis of hyperoxia-induced brain injury
    Mark Dzietko
    Department of Neonatology, Charite, Universitatsmedizin Berlin, Campus Virchow Klinikum, Berlin, Germany
    Ann Neurol 64:664-73. 2008
    ..We investigated the role of the Fas death receptor pathway in oxygen-triggered developmental brain injury...
  58. doi Ibuprofen augments bilirubin toxicity in rat cortical neuronal culture
    Monika Berns
    Department of Neonatology, Charite Universitatsmedizin Berlin, Berlin 13353, Germany
    Pediatr Res 65:392-6. 2009
    ..The study demonstrates that bilirubin in low concentration of 10 microM reduces neuron viability and ibuprofen increases this effect. Apoptosis is the underlying cell death mechanism...
  59. doi Parental bilingualism is associated with slower cognitive development in very low birth weight infants
    Elisabeth Walch
    Charite Universitatsmedizin Berlin, Campus Virchow Klinikum, Department of Neonatology, Berlin, Germany
    Early Hum Dev 85:449-54. 2009
    ..Speech development is frequently impaired in very low birth weight (VLBW) infants. Few and controversial data have been published on concepts regarding the influence of bilingual education...
  60. doi Extreme polycythemia in recipient twin with twin-to-twin transfusion syndrome: a case report
    Ute Braig
    Department of Obstetrics, Charite Campus Virchow Klinikum, Berlin, Germany
    Fetal Diagn Ther 25:206-10. 2009
    ..Perinatal outcome of both twins was good. Conclusion: Even in a stable course of pregnancy with stage I TTTS, severe polycythemia of the recipient twin can occur and can require careful PET in a specialized center...
  61. ncbi Progressive multicystic encephalopathy: is there more than hypoxia-ischemia?
    Lars Garten
    Department of Neonatology, University Charité, Berlin, Germany
    J Child Neurol 22:645-9. 2007
    ..As in this case, if the criteria of an acute hypoxic event sufficient to cause neonatal encephalopathy are not met, then factors other than hypoxia-ischemia may be leading to progressive multicystic encephalopathy...
  62. doi Trace elements and antioxidant enzymes in extremely low birthweight infants
    Andrea Loui
    Department of Neonatology, Charite Virchow Hospital, Humboldt University Berlin, Germany
    J Trace Elem Med Biol 24:111-8. 2010
    ..Lower trace element concentrations, did not affect the activities of CuZn-SOD, GSH-Px, and CAT. Typical diseases of prematurity were not associated with decreased antioxidant enzyme activities...
  63. doi Echocardiography predicts closure of patent ductus arteriosus in response to ibuprofen in infants less than 28 week gestational age
    Christiane Pees
    Department of Neonatology, Charite, Universitatsmedizin Berlin, Berlin, Germany
    Early Hum Dev 86:503-8. 2010
    ..The aim of this study was to determine whether echocardiographic parameters can predict response to ibuprofen treatment of PDA...
  64. ncbi Intrauterine onset of acute neuropathic type 2 Gaucher disease: identification of a novel insertion sequence
    Ursula Felderhoff-Mueser
    Department of Neonatology, Charite, Campus Virchow Klinikum, Berlin, Germany
    Am J Med Genet A 128:138-43. 2004
    ..The transheterozygous combination of a mutation, previously described in type 1 Gaucher disease, together with a newly identified insertion may result in this severe phenotype...
  65. doi B-type natriuretic peptide to predict ductus intervention in infants <28 weeks
    Christoph Czernik
    Department of Neonatology, Medical University Berlin, Berlin, Germany
    Pediatr Res 64:286-90. 2008
    ..86) with the best cutoff at 550 pg/mL on the second day of life in ventilated infants less than 28 wk gestation (sensitivity: 83%; specificity: 86%)...
  66. ncbi Nutrition of very low birth weight infants fed human milk with or without supplemental trace elements: a randomized controlled trial
    Andrea Loui
    Department of Neonatology, Charite Virchow Hospital, Berlin, Germany
    J Pediatr Gastroenterol Nutr 39:346-53. 2004
    ....
  67. ncbi Interleukin-1beta, interleukin-18, and interferon-gamma expression in the cerebrospinal fluid of premature infants with posthemorrhagic hydrocephalus--markers of white matter damage?
    Thomas Schmitz
    Department of Neonatology, Campus Virchow Klinikum, Charite Universitatsmedizin Berlin, 13353 Berlin, Germany
    Pediatr Res 61:722-6. 2007
    ..Higher IFN-gamma levels are detected in a subgroup of patients developing cWMD, indicating its involvement in the pathogenesis of cWMD in the context of PHHC...
  68. ncbi Estradiol attenuates hyperoxia-induced cell death in the developing white matter
    Bettina Gerstner
    Department of Neonatology, Charite Campus Virchow Klinikum, Berlin, Germany
    Ann Neurol 61:562-73. 2007
    ..Furthermore, neuroprotective properties have been attributed to estrogens. We examined the effect of E2 on hyperoxia-induced cell death in the developing white matter in the rat brain...
  69. doi Impaired word stress pattern discrimination in very-low-birthweight infants during the first 6 months of life
    Birgit Herold
    Klinik für Neonatologie, Campus Virchow Klinikum, Charite Universitatsmedizin Berlin, Berlin, Germany
    Dev Med Child Neurol 50:678-83. 2008
    ..Preterm birth and deficient early prosodic information affect prosodic processing during the first half year of life...
  70. ncbi Caspase-1-processed interleukins in hyperoxia-induced cell death in the developing brain
    Ursula Felderhoff-Mueser
    Department of Neonatology, Charite, Campus Virchow Klinikum, Humboldt University Medical Center, Augustenburger Platz 1, D 13353 Berlin, Germany
    Ann Neurol 57:50-9. 2005
    ..These cytokines might serve as useful targets for therapeutic approaches aimed at preserving neuronal function in the immature brain, which is exquisitely sensitive to a variety of iatrogenic measures including oxygen...
  71. ncbi Vascular endothelial growth factor and transforming growth factor-beta1 are highly expressed in the cerebrospinal fluid of premature infants with posthemorrhagic hydrocephalus
    Axel Heep
    Department of Neonatology, University of Bonn, Adenauerallee 119, D 53113 Bonn, Germany
    Pediatr Res 56:768-74. 2004
    ..TGF-beta1 CSF concentrations are not elevated in the phase of acute fibroproliferative reactions in patients with PHHC...
  72. ncbi Glutaric acid and its metabolites cause apoptosis in immature oligodendrocytes: a novel mechanism of white matter degeneration in glutaryl-CoA dehydrogenase deficiency
    Bettina Gerstner
    Department of Neonatology, Charite Campus Virchow Klinikum, D 13353 Berlin, Germany
    Pediatr Res 57:771-6. 2005
    ..GA, GC, and 3-OH-GA directly initiate the apoptotic cascade in oligodendroglia cells. This mechanism may contribute to the white matter damage observed in glutaryl-CoA dehydrogenase deficiency...
  73. ncbi Severe transient cardiac failure caused by placental chorangiosis
    Thomas Schmitz
    Department of Neonatology, Campus Virchow Klinikum, Charite Universitatsmedizin Berlin, Berlin, Germany
    Neonatology 91:271-4. 2007
    ..Chorangiomas are villous capillary tumors of the placenta with high impact on neonatal morbidity and mortality. Cardiac complications have occasionally been reported...
  74. ncbi Neonate with spinal hypoplasia on T12 and a localized vertebral malformation on L4
    A Weber
    Department of Neonatology, Campus Virchow Klinikum, University Hospital Charite, Humboldt University, Berlin, Germany
    J Child Neurol 16:619-21. 2001
    ..In previously described cases of sectional spinal dysgenesis, the vertebral and spinal cord malformations are usually found on the same level. Our case may represent a new variant of spinal dysgenesis...
  75. ncbi Predicting chronic lung disease in very low birthweight infants: comparison of 3 scores
    J Hentschel
    Dept of Neonatology, Charite Virchow Klinikum, Humboldt University, Berlin, Germany
    J Perinat Med 26:378-83. 1998
    ..To evaluate 3 scores in their ability to predict Chronic Lung Disease (CLD) in very low birthweight (VLBW) infants...
  76. ncbi Fetal-onset severe skeletal muscle glycogenosis associated with phosphorylase-b kinase deficiency
    C Buhrer
    Department of Neonatology, Charite Virchow Klinikum, Humboldt University, Berlin, Germany
    Neuropediatrics 31:104-6. 2000
    ..No mutation was detected in exon 1 of the myophosphorylase gene. No psychomotor development was observed, and the infant died of central apnea at 3 months of age...
  77. ncbi Familial recurrence of spontaneous fetal intracranial hemorrhage: ultrasonographic diagnosis and postnatal magnetic resonance imaging (MRI)
    U Felderhoff-Müser
    Department of Neonatology, Charite, Campus Virchow Klinikum, Humboldt University, Berlin, Germany
    Ultrasound Obstet Gynecol 17:248-51. 2001
    ..Vasculopathies, vascular malformations, coagulopathies, thrombocytopenia and relevant metabolic disorders could be excluded...
  78. doi Total serum bilirubin levels during cyclooxygenase inhibitor treatment for patent ductus arteriosus in preterm infants
    C Rheinlaender
    Department of Neonatology, Charite, Campus Virchow Hospital, University Medicine Berlin, Augustenberger Platz 1, Berlin, Germany
    Acta Paediatr 98:36-42. 2009
    ..To determine whether ibuprofen use in VLBW infants is associated with increased serum bilirubin levels and impaired neurodevelopmental outcome at 2 years of age compared to indomethacin...
  79. pmc In-vitro activation of complement system by lactic acidosis in newborn and adults
    F Hecke
    Department of Neonatology, , Humboldt University, Berlin, Germany
    Mediators Inflamm 10:27-31. 2001
    ..CONCLUSION: Lactic acidosis leads to an activation of the entire complement system in neonates and in adults. This activation is dose-dependent and more pronounced in adults as compared to neonates...
  80. ncbi Il-1 beta, Il-6, Il-8 and G-CSF in the diagnosis of early-onset neonatal infections
    U Buscher
    Department of Obstetrics, Charite, Campus Virchow Klinikum, Humboldt University, Berlin, Germany
    J Perinat Med 28:383-8. 2000
    ..To determine whether inflammatory cytokine concentrations (Il-1 beta, Il-6, Il-8 and G-CSF) in umbilical cord blood are useful predictors of an early-onset neonatal infection...
  81. ncbi Urinary S-100B concentrations in term and preterm infants at risk for brain damage
    Katharina Ruetzler
    Department of Neonatology, Charite Campus Virchow Klinikum, Berlin, Germany
    Biol Neonate 89:260-4. 2006
    ..Elevated serum concentrations of S-100B, a 21-kDa protein expressed in astroglial cells, has been used to assess cerebral damage after head trauma, infection, ischemia, and perinatal asphyxia...
  82. ncbi Vascular endothelial growth factor and erythropoietin concentrations in cerebrospinal fluid of children with hydrocephalus
    Petra Koehne
    Klinik für Neonatologie, Charite Virchow Klinikum, 13344 Berlin, Germany
    Childs Nerv Syst 18:137-41. 2002
    ..We set up the hypothesis that elevated intracranial pressure in patients with hydrocephalus triggers release of VEGF and EPO into cerebrospinal fluid (CSF)...
  83. doi [Harlequin ichthyosis--medical and psychosocial challenges]
    E Eilers
    Klinik für Neonatologie, Campus Virchow Klinik, Charite Universitatsmedizin Berlin, Augustenburger Platz 1, Berlin
    Klin Padiatr 222:86-69. 2010
    ..However, the outcome in our case is impaired by severe psychomotor developmental delay, which has not yet been associated with Harlequin Ichthyosis...
  84. ncbi Ultrasonic surfactant nebulization with different exciting frequencies
    M H Wagner
    Department of Neonatology, Charite, Campus Virchow Klinikum, Humboldt University, Berlin, Germany
    Biophys Chem 84:35-43. 2000
    ..Although possible, ultrasonic nebulization of surfactant suspensions is ineffective because of a striking decrease in phospholipid content...
  85. ncbi Mild postischemic hypothermia is neuroprotective in the immature rat neocortex slice
    H Ko
    Department of Neonatology, Charite Campus Virchow Klinikum, Augustenburger Platz 1, D 13353, Berlin, Germany
    Brain Res 894:297-300. 2001
    ..These data indicate that mild postischemic hypothermia may have neuroprotective effects after perinatal asphyxia...
  86. ncbi Use of 2% 2-phenoxyethanol and 0.1% octenidine as antiseptic in premature newborn infants of 23-26 weeks gestation
    C Buhrer
    Departmenmt of Neonatology, Charite Medical Center, Virchow Hospital, Berlin, Germany
    J Hosp Infect 51:305-7. 2002
    ..2-Phenoxyethanol is readily absorbed by the newborn's skin but apparently undergoes extensive oxidative metabolization to 2-phenoxyacetic acid...
  87. ncbi Bilateral agenesis of the superior vena cava associated with congenital hydrothorax
    S Romer
    Department of Neonatology, Charite Campus Virchow Klinikum, Berlin, Germany
    Ultrasound Obstet Gynecol 28:842-4. 2006
    ..The cardiac anomaly was confirmed by postnatal magnetic resonance angiography. The chylothorax disappeared with conservative therapy...
  88. doi Urinary loss of erythropoietin after intravenous versus subcutaneous epoetin-beta in preterm infants
    Juliane Langer
    Klinik für Neonatologie, Campus Virchow Klinikum, Charite Universitatsmedizin, Berlin, Germany
    J Pediatr 152:728-30. 2008
    ....
  89. ncbi Arthrogryposis multiplex with deafness, inguinal hernias, and early death: a family report of a probably autosomal recessive trait
    Christian Tiemann
    Department of Neonatology, Charite Medical Center, Virchow Hospital, Berlin, Germany
    Am J Med Genet A 137:125-9. 2005
    ..This new syndrome is probably transmitted in an autosomal recessive mode, although X-linked inheritance cannot be excluded...
  90. ncbi Genetic deafness in a preterm infant with a critical postnatal course
    Petra S Koehne
    Department of Neonatology, Charite, Campus Virchow Klinikum, Humboldt University, Berlin, Germany
    Pediatr Crit Care Med 7:270-2. 2006
    ..We describe the severe postnatal course and review the relevant literature...
  91. ncbi Suramin induces and enhances apoptosis in a model of hyperoxia-induced oligodendrocyte injury
    Simone Stark
    Department of Neonatology, Campus Virchow Klinikum, Charite, Universitatsmedizin Berlin, D 13353 Berlin, Germany
    Neurotox Res 13:197-207. 2008
    ..Its mechanism of action includes an increase of previously described hyperoxia-induced expression of pro-apoptotic factors and deprivation of growth factor dependent signaling components...
  92. doi The expression of VEGF and its receptors in the human ductus arteriosus
    Sven C Weber
    Department of Neonatology, Humboldt University, 13353 Berlin, Germany
    Pediatr Res 64:340-5. 2008
    ..In contrast, VEGF-R2 is the predominant receptor in later angiogenic signaling...
  93. ncbi Hyperoxia causes inducible nitric oxide synthase-mediated cellular damage to the immature rat brain
    Thomas Hoehn
    Neonatology and Pediatric Intensive Care, University Children s Hospital, Heinrich Heine University, Moorenstr 5, 40225 Dusseldorf, Germany
    Pediatr Res 54:179-84. 2003
    ..Positive neuronal nitrotyrosine staining indicates formation of peroxynitrite with potential deleterious effects for immature cellular structures in the neonatal brain...
  94. ncbi Exposure to HIV and antiretroviral medication as a potential cause of necrotizing enterocolitis in term neonates
    Thomas Schmitz
    AIDS 20:1082-3. 2006
  95. ncbi Insulin-like growth factors and binding proteins in early milk from mothers of preterm and term infants
    Martin W Elmlinger
    Pediatric Endocrinology Section, University Children s Hospital, Tubingen, Germany
    Horm Res 68:124-31. 2007
    ..The results provide further evidence that IGFBP-2 and IGF-II in breast milk are relevant factors for the early development of preterm infants...
  96. ncbi Urinary losses of recombinant erythropoietin in preterm infants
    Christoph Buhrer
    J Pediatr 142:452-3. 2003
  97. ncbi Outbreaks in neonatal intensive care units - they are not like others
    Petra Gastmeier
    Institute for Medical Microbiology and Hospital Epidemiology, Medical School, Hannover, Germany
    Am J Infect Control 35:172-6. 2007
    ..The objective of this systematic review was to identify differences between outbreaks of health care-associated infections in NICUs and other ICUs as reported to date in the medical literature...
  98. ncbi Early treatment with erythropoietin beta ameliorates anemia and reduces transfusion requirements in infants with birth weights below 1000 g
    Rolf F Maier
    J Pediatr 141:8-15. 2002
    ..To investigate whether recombinant erythropoietin (rhEPO) reduces the need for transfusion in extremely low birth weight (ELBW) infants (birth weight 500-999 g) and to determine the optimal time for treatment...