Aurelia Noske

Summary

Affiliation: Humboldt University
Country: Germany

Publications

  1. doi Expression of the nuclear export protein chromosomal region maintenance/exportin 1/Xpo1 is a prognostic factor in human ovarian cancer
    Aurelia Noske
    Institute of Pathology, Charite University Hospital, Berlin, Germany
    Cancer 112:1733-43. 2008
  2. doi Flat epithelial atypia is a common subtype of B3 breast lesions and is associated with noninvasive cancer but not with invasive cancer in final excision histology
    Aurelia Noske
    Institute of Pathology, Universitätsmedizin Charité Berlin, 10117 Berlin, Germany
    Hum Pathol 41:522-7. 2010
  3. ncbi Specific inhibition of AKT2 by RNA interference results in reduction of ovarian cancer cell proliferation: increased expression of AKT in advanced ovarian cancer
    Aurelia Noske
    Institute of Pathology, Charite University Hospital Berlin, Campus Mitte, Schumannstr 20 21, D 10117 Berlin, Germany
    Cancer Lett 246:190-200. 2007
  4. doi Report of a metaplastic carcinoma of the breast with multi-directional differentiation: an adenoid cystic carcinoma, a spindle cell carcinoma and melanoma
    Aurelia Noske
    Institute of Pathology, Charite University Hospital Berlin, Campus Mitte, Chariteplatz 1, Berlin 10117, Germany
    Virchows Arch 452:575-9. 2008
  5. ncbi Loss of Gelsolin expression in human ovarian carcinomas
    Aurelia Noske
    Institute of Pathology, University Hospital Charite, Schumannstr 20 21, D 10117 Berlin, Germany
    Eur J Cancer 41:461-9. 2005
  6. ncbi Activation of mTOR in a subgroup of ovarian carcinomas: correlation with p-eIF-4E and prognosis
    Aurelia Noske
    Institute of Pathology, Charite University Hospital, Campus Mitte, D 10117 Berlin, Germany
    Oncol Rep 20:1409-17. 2008
  7. doi IMP3 expression in human ovarian cancer is associated with improved survival
    Aurelia Noske
    Institute of Pathology, Charite University Hospital Berlin, Germany
    Int J Gynecol Pathol 28:203-10. 2009
  8. doi Topoisomerase IIalpha mRNA and protein expression in ovarian carcinoma: correlation with clinicopathological factors and prognosis
    Areeg Faggad
    Institute of Pathology, Charite University Hospital, Berlin, Germany
    Mod Pathol 22:579-88. 2009
  9. doi Expression of classical NF-kappaB pathway effectors in human ovarian carcinoma
    Silvia Darb-Esfahani
    Institute of Pathology, Charite Universitatsmedizin Berlin, Campus Mitte, Berlin
    Histopathology 56:727-39. 2010
  10. ncbi Expression of the ELAV-like protein HuR in human prostate carcinoma is an indicator of disease relapse and linked to COX-2 expression
    Silvia Niesporek
    Institute of Pathology, Charite Universitatsmedizin Berlin, Campus Mitte, Chariteplatz 1, Berlin, Germany
    Int J Oncol 32:341-7. 2008

Detail Information

Publications43

  1. doi Expression of the nuclear export protein chromosomal region maintenance/exportin 1/Xpo1 is a prognostic factor in human ovarian cancer
    Aurelia Noske
    Institute of Pathology, Charite University Hospital, Berlin, Germany
    Cancer 112:1733-43. 2008
    ..Whereas cell-biologic studies have suggested a fundamental role for CRM1 in the regulation of mitosis, the expression of this protein in human tumor tissue has not been investigated to date...
  2. doi Flat epithelial atypia is a common subtype of B3 breast lesions and is associated with noninvasive cancer but not with invasive cancer in final excision histology
    Aurelia Noske
    Institute of Pathology, Universitätsmedizin Charité Berlin, 10117 Berlin, Germany
    Hum Pathol 41:522-7. 2010
    ..We conclude that an excision biopsy after diagnosis of flat epithelial atypia is recommended depending on clinical and radiologic findings...
  3. ncbi Specific inhibition of AKT2 by RNA interference results in reduction of ovarian cancer cell proliferation: increased expression of AKT in advanced ovarian cancer
    Aurelia Noske
    Institute of Pathology, Charite University Hospital Berlin, Campus Mitte, Schumannstr 20 21, D 10117 Berlin, Germany
    Cancer Lett 246:190-200. 2007
    ..Deactivation of AKT, especially AKT2 can result in reduction of cell growth. Accordingly, AKT is an interesting target for therapeutic intervention in ovarian cancer...
  4. doi Report of a metaplastic carcinoma of the breast with multi-directional differentiation: an adenoid cystic carcinoma, a spindle cell carcinoma and melanoma
    Aurelia Noske
    Institute of Pathology, Charite University Hospital Berlin, Campus Mitte, Chariteplatz 1, Berlin 10117, Germany
    Virchows Arch 452:575-9. 2008
    ..This is the first report on a metaplastic carcinoma of the breast presenting as an admixture of an adenoid cystic carcinoma and melanoma...
  5. ncbi Loss of Gelsolin expression in human ovarian carcinomas
    Aurelia Noske
    Institute of Pathology, University Hospital Charite, Schumannstr 20 21, D 10117 Berlin, Germany
    Eur J Cancer 41:461-9. 2005
    ..We observed an upregulation of gelsolin in ovarian cancer cells after treatment with both types of inhibitor. Our results suggest that gelsolin might be involved in the growth regulation of human ovarian cancer...
  6. ncbi Activation of mTOR in a subgroup of ovarian carcinomas: correlation with p-eIF-4E and prognosis
    Aurelia Noske
    Institute of Pathology, Charite University Hospital, Campus Mitte, D 10117 Berlin, Germany
    Oncol Rep 20:1409-17. 2008
    ..The design of future clinical trials should incorporate biomarker testing to determine predictive markers for response to mTOR inhibitors...
  7. doi IMP3 expression in human ovarian cancer is associated with improved survival
    Aurelia Noske
    Institute of Pathology, Charite University Hospital Berlin, Germany
    Int J Gynecol Pathol 28:203-10. 2009
    ..414, P=0.006), as well as a correlation of IMP3 mRNA expression with patient overall survival (P=0.044), was observed. Our results demonstrate that IMP3 is expressed in a subpopulation of ovarian cancer and a marker of good prognosis...
  8. doi Topoisomerase IIalpha mRNA and protein expression in ovarian carcinoma: correlation with clinicopathological factors and prognosis
    Areeg Faggad
    Institute of Pathology, Charite University Hospital, Berlin, Germany
    Mod Pathol 22:579-88. 2009
    ..Our results encourage the further evaluation of the prognostic and predictive values of Top IIalpha expression in ovarian carcinoma, which might help to assess the patients' risk profile, and the planning of an individualized therapy...
  9. doi Expression of classical NF-kappaB pathway effectors in human ovarian carcinoma
    Silvia Darb-Esfahani
    Institute of Pathology, Charite Universitatsmedizin Berlin, Campus Mitte, Berlin
    Histopathology 56:727-39. 2010
    ..However, surprisingly little is known of the expression of effectors of the NF-kappaB pathway in human ovarian cancer in vivo...
  10. ncbi Expression of the ELAV-like protein HuR in human prostate carcinoma is an indicator of disease relapse and linked to COX-2 expression
    Silvia Niesporek
    Institute of Pathology, Charite Universitatsmedizin Berlin, Campus Mitte, Chariteplatz 1, Berlin, Germany
    Int J Oncol 32:341-7. 2008
    ..Our results point to a potential prognostic role of HuR expression in prostate cancer diagnostics and propose HuR as a future therapeutic target in prostate cancer therapy...
  11. ncbi Expression patterns of polo-like kinase 1 in human gastric cancer
    Wilko Weichert
    Institut fur Pathologie, Charite Universitatsmedizin, Schumannstrasse 20 21, 10117 Berlin, Germany
    Cancer Sci 97:271-6. 2006
    ....
  12. doi Phospho-mTOR and phospho-4EBP1 in endometrial adenocarcinoma: association with stage and grade in vivo and link with response to rapamycin treatment in vitro
    Silvia Darb-Esfahani
    Institute of Pathology, Charite Universitatsmedizin Berlin, Campus Mitte, Chariteplatz 1, 10117, Berlin, Germany
    J Cancer Res Clin Oncol 135:933-41. 2009
    ..Yet, data on the expression of mTOR cascade components in endometrial cancer are lacking...
  13. doi mTOR expression and activity patterns in gastroenteropancreatic neuroendocrine tumours
    Atsuko Kasajima
    Institute of Pathology Department of Internal Medicine, Charite Universitatsmedizin, Berlin, Germany
    Endocr Relat Cancer 18:181-92. 2011
    ..We hypothesise that these differences in mTOR expression and activity might possibly influence response to mTOR inhibitors...
  14. pmc High class I HDAC activity and expression are associated with RelA/p65 activation in pancreatic cancer in vitro and in vivo
    Annika Lehmann
    Institute of Pathology, Charite University Hospital, Berlin, Germany
    BMC Cancer 9:395. 2009
    ..The strong association between aberrant HDAC activity and the occurrence of cancer has led to the development of a variety of HDAC inhibitors (HDIs), which emerge as promising new targeted anticancer therapeutics...
  15. doi Vascular endothelial growth factor C mRNA expression is a prognostic factor in epithelial ovarian cancer as detected by kinetic RT-PCR in formalin-fixed paraffin-embedded tissue
    Bruno V Sinn
    Institute of Pathology, Charite Universitatsmedizin Berlin, Campus Mitte, Chariteplatz 1, 10117, Berlin, Germany
    Virchows Arch 455:461-7. 2009
    ..Our study demonstrates that high VEGF-C expression is associated with aggressive tumor behavior in ovarian cancer. mRNA extracted from paraffin-embedded tumor samples is suitable for VEGF-C gene expression studies...
  16. doi A prognostic gene expression index in ovarian cancer - validation across different independent data sets
    Carsten Denkert
    Institute of Pathology, Charite University Hospital, Berlin, Germany
    J Pathol 218:273-80. 2009
    ..As traditional treatment options are limited, this analysis may be able to optimize clinical management and to identify those patients who would be candidates for new therapeutic strategies...
  17. pmc An intracellular targeted antibody detects EGFR as an independent prognostic factor in ovarian carcinomas
    Aurelia Noske
    Institute of Pathology, University Hospital Charite Berlin, Germany
    BMC Cancer 11:294. 2011
    ..In ovarian cancer, the reported rate of EGFR expression varies between 4-70% depending on assessment method and data on patient outcome are conflicting...
  18. ncbi Expression of the ELAV-like protein HuR in human colon cancer: association with tumor stage and cyclooxygenase-2
    Carsten Denkert
    Institute of Pathology, Charite University Hospital, Berlin, Germany
    Mod Pathol 19:1261-9. 2006
    ..Based on our results, further studies are necessary to investigate whether HuR might be a potential target for a molecular tumor therapy...
  19. ncbi Polo-like kinase isoforms in breast cancer: expression patterns and prognostic implications
    Wilko Weichert
    Institute of Pathology, Charite University Hospital, Schumannstrasse 20 21, 10117, Berlin, Germany
    Virchows Arch 446:442-50. 2005
    ..Therefore, in vivo inhibition of PLK family members might represent a rewarding approach in the development of new anticancer drugs for this tumor entity...
  20. pmc Genome-wide gene expression profiling of formalin-fixed paraffin-embedded breast cancer core biopsies using microarrays
    Jan Budczies
    Institute of Pathology, Charite Universitatsmedizin Berlin, Germany
    J Histochem Cytochem 59:146-57. 2011
    ..This opens new opportunities for biomarker detection studies and the integration of microarrays into the workflow of cancer diagnostics...
  21. ncbi Polo-like kinase 1 expression is a prognostic factor in human colon cancer
    Wilko Weichert
    Institute of Pathology, Charite University Hospital, Schumannstrabe 20 21, Berlin 10117, Germany
    World J Gastroenterol 11:5644-50. 2005
    ..To clarify the expression patterns and prognostic implications of the mitotic regulator Polo-like kinase 1 (PLK1) in colon cancer...
  22. doi Class I histone deacetylase expression has independent prognostic impact in human colorectal cancer: specific role of class I histone deacetylases in vitro and in vivo
    Wilko Weichert
    Institut fur Pathologie, Charite Universitatsmedizin, Berlin, Germany
    Clin Cancer Res 14:1669-77. 2008
    ..However, despite the importance of these molecules, comparably little is known on expression patterns and functions of specific HDAC isoforms in colorectal cancer...
  23. ncbi Overexpression of cyclooxygenase-2 in human prostate carcinoma and prostatic intraepithelial neoplasia-association with increased expression of Polo-like kinase-1
    Carsten Denkert
    Institute of Pathology, Charite Hospital, Berlin, Germany
    Prostate 67:361-9. 2007
    ..Cyclooxygenases (COX) as well as Polo-like kinases (PLK) are involved in proliferation and cell cycle regulation and have been suggested for preventive and therapeutic approaches in prostate carcinoma...
  24. doi Prognostic impact of AMP-activated protein kinase expression in ovarian carcinoma: correlation of protein expression and GC/TOF-MS-based metabolomics
    Ann Christin Buckendahl
    Institute of Pathology, Charite Universitaetsmedizin Berlin, Chariteplatz 1, D 10117 Berlin, Germany
    Oncol Rep 25:1005-12. 2011
    ..In future clinical studies, activation of AMPK in ovarian carcinoma patients with advanced tumor stages might be an interesting therapeutic approach...
  25. doi Estrogen receptor 1 mRNA is a prognostic factor in ovarian carcinoma: determination by kinetic PCR in formalin-fixed paraffin-embedded tissue
    Silvia Darb-Esfahani
    Institute of Pathology, Charite Universitatsmedizin Berlin, Berlin, Germany
    Endocr Relat Cancer 16:1229-39. 2009
    ....
  26. doi Tumor-associated lymphocytes as an independent predictor of response to neoadjuvant chemotherapy in breast cancer
    Carsten Denkert
    Institute of Pathology, Charite Hospital, Campus Mitte, Schumannstr 20 21, D 10117 Berlin, Germany
    J Clin Oncol 28:105-13. 2010
    ....
  27. pmc Expression of class I histone deacetylases indicates poor prognosis in endometrioid subtypes of ovarian and endometrial carcinomas
    Wilko Weichert
    Institute of Pathology, Charite Universitatsmedizin, Berlin, Germany
    Neoplasia 10:1021-7. 2008
    ..9-23.3). The independent prognostic information and the overall high rate of expression for class I HDACs suggest that these targets should be explored as predictive factors in ovarian and endometrial carcinomas prospectively...
  28. doi Expression of multidrug resistance-associated protein 1 in invasive ovarian carcinoma: implication for prognosis
    Areeg Faggad
    Institute of Pathology, Charite University Hospital, Berlin, Germany
    Histopathology 54:657-66. 2009
    ..The aim of this study was to investigate the expression of multidrug resistance-associated protein 1 (MRP1) and to assess the possible associations with clinicopathological variables and patient outcome in primary ovarian carcinoma...
  29. doi Down-regulation of the antigen processing machinery is linked to a loss of inflammatory response in colorectal cancer
    Atsuko Kasajima
    Institute of Pathology, Charite Universitatsmedizin, Berlin, Germany
    Hum Pathol 41:1758-69. 2010
    ..This implies that modulation of these factors may help to enhance antitumor inflammatory response which in turn may improve patient prognosis...
  30. pmc Identification of biology-based breast cancer types with distinct predictive and prognostic features: role of steroid hormone and HER2 receptor expression in patients treated with neoadjuvant anthracycline/taxane-based chemotherapy
    Silvia Darb-Esfahani
    Institute of Pathology, Charite Universitatsmedizin Berlin, Chariteplatz 1, Berlin, 10117, Germany
    Breast Cancer Res 11:R69. 2009
    ....
  31. ncbi Expression of the ELAV-like protein HuR is associated with higher tumor grade and increased cyclooxygenase-2 expression in human breast carcinoma
    Carsten Denkert
    Institute of Pathology, Charite Hospital, Berlin, Germany
    Clin Cancer Res 10:5580-6. 2004
    ..Cell culture studies have shown that the mRNA of cyclooxygenase (COX)-2 can be stabilized by HuR...
  32. doi Aldehyde dehydrogenase 1/epidermal growth factor receptor coexpression is characteristic of a highly aggressive, poor-prognosis subgroup of high-grade serous ovarian carcinoma
    Catarina Alisa Liebscher
    Institute of Pathology, Charite Universitatsmedizin Berlin, 10117 Berlin, Germany
    Hum Pathol 44:1465-71. 2013
    ..Double positivity for both markers identifies a subgroup of highly aggressive, poor-prognosis cancers for which alternative treatment options-potentially EGFR-targeting drugs-should be evaluated. ..
  33. doi Solid neuroendocrine carcinomas of the breast: metastases or primary tumors?
    Christiane Richter-Ehrenstein
    Department of Gynecology, Interdisciplinary Breast Center, Charite University Medicine Berlin, Charite Platz 1, 10117, Berlin, Germany
    Breast Cancer Res Treat 124:413-7. 2010
    ..This is of utmost importance, especially for surgical management...
  34. pmc Metabolite profiling of human colon carcinoma--deregulation of TCA cycle and amino acid turnover
    Carsten Denkert
    Institute of Pathology, Charite University Hospital, 10117 Berlin, Germany
    Mol Cancer 7:72. 2008
    ..However, in contrast to genomics and proteomics, comprehensive metabolomic investigations of alterations in malignant tumors have rarely been conducted...
  35. ncbi Combination of p53 expression and p21 loss has an independent prognostic impact on sporadic colorectal cancer
    Aurelia Noske
    Institute of Pathology, Charite University Hospital Berlin, Campus Mitte, Berlin, Germany
    Oncol Rep 22:3-9. 2009
    ..6, p=0.027). Our data suggest that the assessment of both p53 and p21 expression may provide prognostic information in colorectal cancer patients. This combination might be helpful to identify patients who could benefit from chemotherapy...
  36. doi Therapeutic potential of CAMPATH-1H in skeletal tumours
    Raphaela Fritsche-Guenther
    Institute of Pathology, Charite Universitatsmedizin Berlin, Chariteplatz 1, D 10117 Berlin, Germany
    Histopathology 57:851-61. 2010
    ..The aim of this study was to analyse tissue and cell lines of non-neoplastic bone, cartilage and skeletal tumours for CD52 expression...
  37. ncbi Suppression of the TIG3 tumor suppressor gene in human ovarian carcinomas is mediated via mitogen-activated kinase-dependent and -independent mechanisms
    Kristina Lotz
    Institute of Pathology, University Hospital Charite, Berlin, Germany
    Int J Cancer 116:894-902. 2005
    ..These results suggest that TIG3 is negatively regulated by an activated MEK-ERK signaling pathway. Further mechanisms must interfere with TIG3 expression that are independent of MEK and partially include interferon-responsive components...
  38. doi De novo expression of EphA2 in osteosarcoma modulates activation of the mitogenic signalling pathway
    Raphaela Fritsche-Guenther
    Institute of Pathology, Charite Universitatsmedizin Berlin, Berlin, Germany
    Histopathology 57:836-50. 2010
    ..The aim of this study was to elucidate the molecular mechanisms governing osteosarcoma development and dissemination and, thereby, to identify possible novel drug targets for improved treatment...
  39. doi Diagnostic accuracy and prognostic value of core biopsy in the management of breast cancer: a series of 542 patients
    Christiane Richter-Ehrenstein
    Department of Gynecology, Charite, Universitatsmedizin Berlin
    Int J Surg Pathol 17:323-6. 2009
    ..Core biopsy is considered to be a highly accurate method for gaining preoperative diagnosis of breast cancer. The purpose of this study is to compare the results of core biopsy with those of the surgical excision specimen...
  40. doi HMGA2 gene is a promising target for ovarian cancer silencing therapy
    Anastasia Malek
    Department of Pharmacology and Toxicology, Philipps University School of Medicine, Marburg, Germany
    Int J Cancer 123:348-56. 2008
    ..The tumor growth inhibition effect of HMGA2 silencing for Ovcar-3 cells was validated in vivo. Our findings revealed that the HMGA2 gene represents a promising target for gene silencing therapy in ovarian cancer...
  41. ncbi Is reduced expression of mismatch repair genes MLH1 and MSH2 in patients with sporadic colorectal cancer related to their prognosis?
    Martin Kruschewski
    Department of Surgery, University Hospital Benjamin Franklin, Free University of Berlin, Germany
    Clin Exp Metastasis 19:71-7. 2002
    ..In conclusion of our results and a critical review of literature, the prognostic importance of the MMR genes in sporadic colorectal carcinomas remains controversial...
  42. ncbi Combined adenosquamous and large-cell neuroendocrine carcinoma of the gallbladder
    Aurelia Noske
    Virchows Arch 449:135-6. 2006
  43. ncbi Amelanotic metastasis of melanoma mimicking ovarian cancer: a case report and review of the literature
    Klaus Pietzner
    Department of Gynecology and Obstetrics, Charite Campus Virchow Klinikum, University Medicine of Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
    Anticancer Res 28:563-6. 2008
    ..This report discusses the differential diagnosis and clinical management of both metastatic amelanotic malignant melanoma of the ovary and epithelial ovarian cancer...