Research Topics
Genomes and Genes
| Aurelia NoskeSummaryAffiliation: Humboldt University Country: Germany Publications
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Detail Information
Publications
Expression of the nuclear export protein chromosomal region maintenance/exportin 1/Xpo1 is a prognostic factor in human ovarian cancerAurelia Noske
Institute of Pathology, Charite University Hospital, Berlin, Germany
Cancer 112:1733-43. 2008..Whereas cell-biologic studies have suggested a fundamental role for CRM1 in the regulation of mitosis, the expression of this protein in human tumor tissue has not been investigated to date...
Activation of mTOR in a subgroup of ovarian carcinomas: correlation with p-eIF-4E and prognosisAurelia Noske
Institute of Pathology, Charite University Hospital, Campus Mitte, D 10117 Berlin, Germany
Oncol Rep 20:1409-17. 2008..The design of future clinical trials should incorporate biomarker testing to determine predictive markers for response to mTOR inhibitors...- Report of a metaplastic carcinoma of the breast with multi-directional differentiation: an adenoid cystic carcinoma, a spindle cell carcinoma and melanomaAurelia Noske
Institute of Pathology, Charite University Hospital Berlin, Campus Mitte, Chariteplatz 1, Berlin 10117, Germany
Virchows Arch 452:575-9. 2008..This is the first report on a metaplastic carcinoma of the breast presenting as an admixture of an adenoid cystic carcinoma and melanoma... - Loss of Gelsolin expression in human ovarian carcinomasAurelia Noske
Institute of Pathology, University Hospital Charite, Schumannstr 20 21, D 10117 Berlin, Germany
Eur J Cancer 41:461-9. 2005..We observed an upregulation of gelsolin in ovarian cancer cells after treatment with both types of inhibitor. Our results suggest that gelsolin might be involved in the growth regulation of human ovarian cancer... - Flat epithelial atypia is a common subtype of B3 breast lesions and is associated with noninvasive cancer but not with invasive cancer in final excision histologyAurelia Noske
Institute of Pathology, Universitätsmedizin Charité Berlin, 10117 Berlin, Germany
Hum Pathol 41:522-7. 2010..We conclude that an excision biopsy after diagnosis of flat epithelial atypia is recommended depending on clinical and radiologic findings... - IMP3 expression in human ovarian cancer is associated with improved survivalAurelia Noske
Institute of Pathology, Charite University Hospital Berlin, Germany
Int J Gynecol Pathol 28:203-10. 2009..414, P=0.006), as well as a correlation of IMP3 mRNA expression with patient overall survival (P=0.044), was observed. Our results demonstrate that IMP3 is expressed in a subpopulation of ovarian cancer and a marker of good prognosis... - Specific inhibition of AKT2 by RNA interference results in reduction of ovarian cancer cell proliferation: increased expression of AKT in advanced ovarian cancerAurelia Noske
Institute of Pathology, Charite University Hospital Berlin, Campus Mitte, Schumannstr 20 21, D 10117 Berlin, Germany
Cancer Lett 246:190-200. 2007..Deactivation of AKT, especially AKT2 can result in reduction of cell growth. Accordingly, AKT is an interesting target for therapeutic intervention in ovarian cancer... - Topoisomerase IIalpha mRNA and protein expression in ovarian carcinoma: correlation with clinicopathological factors and prognosisAreeg Faggad
Institute of Pathology, Charite University Hospital, Berlin, Germany
Mod Pathol 22:579-88. 2009..Our results encourage the further evaluation of the prognostic and predictive values of Top IIalpha expression in ovarian carcinoma, which might help to assess the patients' risk profile, and the planning of an individualized therapy... - Expression of classical NF-kappaB pathway effectors in human ovarian carcinomaSilvia Darb-Esfahani
Institute of Pathology, Charite Universitatsmedizin Berlin, Campus Mitte, Berlin
Histopathology 56:727-39. 2010..However, surprisingly little is known of the expression of effectors of the NF-kappaB pathway in human ovarian cancer in vivo... - Expression patterns of polo-like kinase 1 in human gastric cancerWilko Weichert
Institut fur Pathologie, Charite Universitatsmedizin, Schumannstrasse 20 21, 10117 Berlin, Germany
Cancer Sci 97:271-6. 2006.... - Expression of the ELAV-like protein HuR in human prostate carcinoma is an indicator of disease relapse and linked to COX-2 expressionSilvia Niesporek
Institute of Pathology, Charite Universitatsmedizin Berlin, Campus Mitte, Chariteplatz 1, Berlin, Germany
Int J Oncol 32:341-7. 2008..Our results point to a potential prognostic role of HuR expression in prostate cancer diagnostics and propose HuR as a future therapeutic target in prostate cancer therapy... - Phospho-mTOR and phospho-4EBP1 in endometrial adenocarcinoma: association with stage and grade in vivo and link with response to rapamycin treatment in vitroSilvia Darb-Esfahani
Institute of Pathology, Charite Universitatsmedizin Berlin, Campus Mitte, Chariteplatz 1, 10117, Berlin, Germany
J Cancer Res Clin Oncol 135:933-41. 2009..Yet, data on the expression of mTOR cascade components in endometrial cancer are lacking... - Vascular endothelial growth factor C mRNA expression is a prognostic factor in epithelial ovarian cancer as detected by kinetic RT-PCR in formalin-fixed paraffin-embedded tissueBruno V Sinn
Institute of Pathology, Charite Universitatsmedizin Berlin, Campus Mitte, Chariteplatz 1, 10117, Berlin, Germany
Virchows Arch 455:461-7. 2009..Our study demonstrates that high VEGF-C expression is associated with aggressive tumor behavior in ovarian cancer. mRNA extracted from paraffin-embedded tumor samples is suitable for VEGF-C gene expression studies... 
High class I HDAC activity and expression are associated with RelA/p65 activation in pancreatic cancer in vitro and in vivoAnnika Lehmann
Institute of Pathology, Charite University Hospital, Berlin, Germany
BMC Cancer 9:395. 2009..The strong association between aberrant HDAC activity and the occurrence of cancer has led to the development of a variety of HDAC inhibitors (HDIs), which emerge as promising new targeted anticancer therapeutics...- mTOR expression and activity patterns in gastroenteropancreatic neuroendocrine tumoursAtsuko Kasajima
Institute of Pathology Department of Internal Medicine, Charite Universitatsmedizin, Berlin, Germany
Endocr Relat Cancer 18:181-92. 2011..We hypothesise that these differences in mTOR expression and activity might possibly influence response to mTOR inhibitors... - A prognostic gene expression index in ovarian cancer - validation across different independent data setsCarsten Denkert
Institute of Pathology, Charite University Hospital, Berlin, Germany
J Pathol 218:273-80. 2009..As traditional treatment options are limited, this analysis may be able to optimize clinical management and to identify those patients who would be candidates for new therapeutic strategies... - An intracellular targeted antibody detects EGFR as an independent prognostic factor in ovarian carcinomasAurelia Noske
Institute of Pathology, University Hospital Charite Berlin, Germany
BMC Cancer 11:294. 2011..In ovarian cancer, the reported rate of EGFR expression varies between 4-70% depending on assessment method and data on patient outcome are conflicting... - Genome-wide gene expression profiling of formalin-fixed paraffin-embedded breast cancer core biopsies using microarraysJan Budczies
Institute of Pathology, Charite Universitatsmedizin Berlin, Germany
J Histochem Cytochem 59:146-57. 2011..This opens new opportunities for biomarker detection studies and the integration of microarrays into the workflow of cancer diagnostics... - Polo-like kinase isoforms in breast cancer: expression patterns and prognostic implicationsWilko Weichert
Institute of Pathology, Charite University Hospital, Schumannstrasse 20 21, 10117, Berlin, Germany
Virchows Arch 446:442-50. 2005..Therefore, in vivo inhibition of PLK family members might represent a rewarding approach in the development of new anticancer drugs for this tumor entity... - Expression of the ELAV-like protein HuR in human colon cancer: association with tumor stage and cyclooxygenase-2Carsten Denkert
Institute of Pathology, Charite University Hospital, Berlin, Germany
Mod Pathol 19:1261-9. 2006..Based on our results, further studies are necessary to investigate whether HuR might be a potential target for a molecular tumor therapy... - Overexpression of cyclooxygenase-2 in human prostate carcinoma and prostatic intraepithelial neoplasia-association with increased expression of Polo-like kinase-1Carsten Denkert
Institute of Pathology, Charite Hospital, Berlin, Germany
Prostate 67:361-9. 2007..Cyclooxygenases (COX) as well as Polo-like kinases (PLK) are involved in proliferation and cell cycle regulation and have been suggested for preventive and therapeutic approaches in prostate carcinoma... - Class I histone deacetylase expression has independent prognostic impact in human colorectal cancer: specific role of class I histone deacetylases in vitro and in vivoWilko Weichert
Institut fur Pathologie, Charite Universitatsmedizin, Berlin, Germany
Clin Cancer Res 14:1669-77. 2008..However, despite the importance of these molecules, comparably little is known on expression patterns and functions of specific HDAC isoforms in colorectal cancer... - Polo-like kinase 1 expression is a prognostic factor in human colon cancerWilko Weichert
Institute of Pathology, Charite University Hospital, Schumannstrabe 20 21, Berlin 10117, Germany
World J Gastroenterol 11:5644-50. 2005..To clarify the expression patterns and prognostic implications of the mitotic regulator Polo-like kinase 1 (PLK1) in colon cancer... - Prognostic impact of AMP-activated protein kinase expression in ovarian carcinoma: correlation of protein expression and GC/TOF-MS-based metabolomicsAnn Christin Buckendahl
Institute of Pathology, Charite Universitaetsmedizin Berlin, Chariteplatz 1, D 10117 Berlin, Germany
Oncol Rep 25:1005-12. 2011..In future clinical studies, activation of AMPK in ovarian carcinoma patients with advanced tumor stages might be an interesting therapeutic approach... - Estrogen receptor 1 mRNA is a prognostic factor in ovarian carcinoma: determination by kinetic PCR in formalin-fixed paraffin-embedded tissueSilvia Darb-Esfahani
Institute of Pathology, Charite Universitatsmedizin Berlin, Berlin, Germany
Endocr Relat Cancer 16:1229-39. 2009.... - Tumor-associated lymphocytes as an independent predictor of response to neoadjuvant chemotherapy in breast cancerCarsten Denkert
Institute of Pathology, Charite Hospital, Campus Mitte, Schumannstr 20 21, D 10117 Berlin, Germany
J Clin Oncol 28:105-13. 2010.... - Down-regulation of the antigen processing machinery is linked to a loss of inflammatory response in colorectal cancerAtsuko Kasajima
Institute of Pathology, Charite Universitatsmedizin, Berlin, Germany
Hum Pathol 41:1758-69. 2010..This implies that modulation of these factors may help to enhance antitumor inflammatory response which in turn may improve patient prognosis... - Expression of multidrug resistance-associated protein 1 in invasive ovarian carcinoma: implication for prognosisAreeg Faggad
Institute of Pathology, Charite University Hospital, Berlin, Germany
Histopathology 54:657-66. 2009..The aim of this study was to investigate the expression of multidrug resistance-associated protein 1 (MRP1) and to assess the possible associations with clinicopathological variables and patient outcome in primary ovarian carcinoma... - Expression of class I histone deacetylases indicates poor prognosis in endometrioid subtypes of ovarian and endometrial carcinomasWilko Weichert
Institute of Pathology, Charite Universitatsmedizin, Berlin, Germany
Neoplasia 10:1021-7. 2008..9-23.3). The independent prognostic information and the overall high rate of expression for class I HDACs suggest that these targets should be explored as predictive factors in ovarian and endometrial carcinomas prospectively... - Identification of biology-based breast cancer types with distinct predictive and prognostic features: role of steroid hormone and HER2 receptor expression in patients treated with neoadjuvant anthracycline/taxane-based chemotherapySilvia Darb-Esfahani
Institute of Pathology, Charite Universitatsmedizin Berlin, Chariteplatz 1, Berlin, 10117, Germany
Breast Cancer Res 11:R69. 2009.... - Solid neuroendocrine carcinomas of the breast: metastases or primary tumors?Christiane Richter-Ehrenstein
Department of Gynecology, Interdisciplinary Breast Center, Charite University Medicine Berlin, Charite Platz 1, 10117, Berlin, Germany
Breast Cancer Res Treat 124:413-7. 2010..This is of utmost importance, especially for surgical management... - Expression of the ELAV-like protein HuR is associated with higher tumor grade and increased cyclooxygenase-2 expression in human breast carcinomaCarsten Denkert
Institute of Pathology, Charite Hospital, Berlin, Germany
Clin Cancer Res 10:5580-6. 2004..Cell culture studies have shown that the mRNA of cyclooxygenase (COX)-2 can be stabilized by HuR... - Metabolite profiling of human colon carcinoma--deregulation of TCA cycle and amino acid turnoverCarsten Denkert
Institute of Pathology, Charite University Hospital, 10117 Berlin, Germany
Mol Cancer 7:72. 2008..However, in contrast to genomics and proteomics, comprehensive metabolomic investigations of alterations in malignant tumors have rarely been conducted... - Therapeutic potential of CAMPATH-1H in skeletal tumoursRaphaela Fritsche-Guenther
Institute of Pathology, Charite Universitatsmedizin Berlin, Chariteplatz 1, D 10117 Berlin, Germany
Histopathology 57:851-61. 2010..The aim of this study was to analyse tissue and cell lines of non-neoplastic bone, cartilage and skeletal tumours for CD52 expression... - Combination of p53 expression and p21 loss has an independent prognostic impact on sporadic colorectal cancerAurelia Noske
Institute of Pathology, Charite University Hospital Berlin, Campus Mitte, Berlin, Germany
Oncol Rep 22:3-9. 2009..6, p=0.027). Our data suggest that the assessment of both p53 and p21 expression may provide prognostic information in colorectal cancer patients. This combination might be helpful to identify patients who could benefit from chemotherapy... - Suppression of the TIG3 tumor suppressor gene in human ovarian carcinomas is mediated via mitogen-activated kinase-dependent and -independent mechanismsKristina Lotz
Institute of Pathology, University Hospital Charite, Berlin, Germany
Int J Cancer 116:894-902. 2005..These results suggest that TIG3 is negatively regulated by an activated MEK-ERK signaling pathway. Further mechanisms must interfere with TIG3 expression that are independent of MEK and partially include interferon-responsive components... - De novo expression of EphA2 in osteosarcoma modulates activation of the mitogenic signalling pathwayRaphaela Fritsche-Guenther
Institute of Pathology, Charite Universitatsmedizin Berlin, Berlin, Germany
Histopathology 57:836-50. 2010..The aim of this study was to elucidate the molecular mechanisms governing osteosarcoma development and dissemination and, thereby, to identify possible novel drug targets for improved treatment... - Diagnostic accuracy and prognostic value of core biopsy in the management of breast cancer: a series of 542 patientsChristiane Richter-Ehrenstein
Department of Gynecology, Charite, Universitatsmedizin Berlin
Int J Surg Pathol 17:323-6. 2009..Core biopsy is considered to be a highly accurate method for gaining preoperative diagnosis of breast cancer. The purpose of this study is to compare the results of core biopsy with those of the surgical excision specimen... - Is reduced expression of mismatch repair genes MLH1 and MSH2 in patients with sporadic colorectal cancer related to their prognosis?Martin Kruschewski
Department of Surgery, University Hospital Benjamin Franklin, Free University of Berlin, Germany
Clin Exp Metastasis 19:71-7. 2002..In conclusion of our results and a critical review of literature, the prognostic importance of the MMR genes in sporadic colorectal carcinomas remains controversial... - HMGA2 gene is a promising target for ovarian cancer silencing therapyAnastasia Malek
Department of Pharmacology and Toxicology, Philipps University School of Medicine, Marburg, Germany
Int J Cancer 123:348-56. 2008..The tumor growth inhibition effect of HMGA2 silencing for Ovcar-3 cells was validated in vivo. Our findings revealed that the HMGA2 gene represents a promising target for gene silencing therapy in ovarian cancer... - Amelanotic metastasis of melanoma mimicking ovarian cancer: a case report and review of the literatureKlaus Pietzner
Department of Gynecology and Obstetrics, Charite Campus Virchow Klinikum, University Medicine of Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
Anticancer Res 28:563-6. 2008..This report discusses the differential diagnosis and clinical management of both metastatic amelanotic malignant melanoma of the ovary and epithelial ovarian cancer... - Combined adenosquamous and large-cell neuroendocrine carcinoma of the gallbladderAurelia Noske
Virchows Arch 449:135-6. 2006