I Nindl

Summary

Affiliation: Humboldt University
Country: Germany

Publications

  1. ncbi request reprint Association of human papillomavirus infections with cutaneous tumors in immunosuppressed patients
    Thomas Meyer
    Institute of Immunology, Clinical Pathology and Molecular Medicine, Lademannbogen 61, 22339, Hamburg, Germany
    Transpl Int 16:146-53. 2003
  2. pmc Identification of differentially expressed genes in cutaneous squamous cell carcinoma by microarray expression profiling
    Ingo Nindl
    Department of Dermatology, Charite, Skin Cancer Center Charite, University Hospital of Berlin, Chariteplatz 1, D 10117 Berlin, Germany
    Mol Cancer 5:30. 2006
  3. pmc Isolation of three novel rat and mouse papillomaviruses and their genomic characterization
    Eric Schulz
    Department of Dermatology, Venereology and Allergy, DKFZ Charité Cooperation, Viral Skin Carcinogenesis Group, Charite, University Hospital, Berlin, Germany
    PLoS ONE 7:e47164. 2012
  4. pmc Cutaneous HPV23 E6 prevents p53 phosphorylation through interaction with HIPK2
    Dorothea Muschik
    Viral Skin Carcinogenesis Group, Division Viral Transformation Mechanisms, German Cancer Research Center DKFZ, DKFZ Charité, Heidelberg, Germany
    PLoS ONE 6:e27655. 2011
  5. pmc Eyebrow hairs from actinic keratosis patients harbor the highest number of cutaneous human papillomaviruses
    Ines Schneider
    Charite, Department of Dermatology, Venereology and Allergy, Skin Cancer Center Charite, University Hospital of Berlin, Berlin, Germany
    BMC Infect Dis 13:186. 2013
  6. pmc Human papillomaviruses and non-melanoma skin cancer: basic virology and clinical manifestations
    Ingo Nindl
    Department of Dermatology, Charite, Skin Cancer Center Charite, University Hospital of Berlin, Chariteplatz 1, D 10117 Berlin, Germany
    Dis Markers 23:247-59. 2007
  7. ncbi request reprint Extension of the typing in a general-primer-PCR reverse-line-blotting system to detect all 25 cutaneous beta human papillomaviruses
    Ingo Nindl
    Department of Dermatology, Venereology and Allergy, Charite, Skin Cancer Center Charite, University Hospital of Berlin, Chariteplatz 1, D 10117 Berlin, Germany
    J Virol Methods 146:1-4. 2007
  8. ncbi request reprint Low prevalence of p53, p16(INK4a) and Ha-ras tumour-specific mutations in low-graded actinic keratosis
    I Nindl
    Department of Dermatology, Charite, Skin Cancer Center Charite, University Hospital of Berlin, Berlin, Germany
    Br J Dermatol 156:34-9. 2007
  9. ncbi request reprint High sensitivity and reproducibility of immunohistochemistry with microagitation
    Ingo Nindl
    Charite, Department of Dermatology, 10117 Berlin, Germany
    Arch Dermatol Res 296:278-81. 2004
  10. ncbi request reprint Assessment of TGF-beta1-mediated growth inhibition of HPV-16- and HPV-18-transfected foreskin keratinocytes during and following immortalization
    Ingo Nindl
    Department of Pathology, Section of Molecular Pathology, Vrije Universiteit Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
    Arch Dermatol Res 295:297-304. 2003

Collaborators

Detail Information

Publications40

  1. ncbi request reprint Association of human papillomavirus infections with cutaneous tumors in immunosuppressed patients
    Thomas Meyer
    Institute of Immunology, Clinical Pathology and Molecular Medicine, Lademannbogen 61, 22339, Hamburg, Germany
    Transpl Int 16:146-53. 2003
    ..All HPV 5- and HPV 8-positive SCCs were from immunosuppressed patients, indicating that infection with HPV 5 and HPV 8 may present an increased risk of SCC development in these patients...
  2. pmc Identification of differentially expressed genes in cutaneous squamous cell carcinoma by microarray expression profiling
    Ingo Nindl
    Department of Dermatology, Charite, Skin Cancer Center Charite, University Hospital of Berlin, Chariteplatz 1, D 10117 Berlin, Germany
    Mol Cancer 5:30. 2006
    ..Carcinogenesis is a multi-step process indicated by several genes up- or down-regulated during tumor progression. This study examined and identified differentially expressed genes in cutaneous squamous cell carcinoma (SCC)...
  3. pmc Isolation of three novel rat and mouse papillomaviruses and their genomic characterization
    Eric Schulz
    Department of Dermatology, Venereology and Allergy, DKFZ Charité Cooperation, Viral Skin Carcinogenesis Group, Charite, University Hospital, Berlin, Germany
    PLoS ONE 7:e47164. 2012
    ..PV types particularly isolated from mice and rats are the basis for new animal models, which are valuable to study PV induced tumors and new treatment options...
  4. pmc Cutaneous HPV23 E6 prevents p53 phosphorylation through interaction with HIPK2
    Dorothea Muschik
    Viral Skin Carcinogenesis Group, Division Viral Transformation Mechanisms, German Cancer Research Center DKFZ, DKFZ Charité, Heidelberg, Germany
    PLoS ONE 6:e27655. 2011
    ..Thus, cutaneous HPV23 E6 prevents HIPK2-mediated p53 Ser 46 phosphorylation, which may favour survival of UV-damaged keratinocytes and skin carcinogenesis by apoptosis evasion...
  5. pmc Eyebrow hairs from actinic keratosis patients harbor the highest number of cutaneous human papillomaviruses
    Ines Schneider
    Charite, Department of Dermatology, Venereology and Allergy, Skin Cancer Center Charite, University Hospital of Berlin, Berlin, Germany
    BMC Infect Dis 13:186. 2013
    ..This study compares the presence of cutaneous HPV types in eyebrow hairs to those in tissues of normal skin and skin lesions of 75 immunocompetent AK patients...
  6. pmc Human papillomaviruses and non-melanoma skin cancer: basic virology and clinical manifestations
    Ingo Nindl
    Department of Dermatology, Charite, Skin Cancer Center Charite, University Hospital of Berlin, Chariteplatz 1, D 10117 Berlin, Germany
    Dis Markers 23:247-59. 2007
    ..Thus, specific EV/cutaneous HPV types as co-factors in association with UV-radiation and the immune system seem to be involved in the early pathogenesis of cutaneous SCC...
  7. ncbi request reprint Extension of the typing in a general-primer-PCR reverse-line-blotting system to detect all 25 cutaneous beta human papillomaviruses
    Ingo Nindl
    Department of Dermatology, Venereology and Allergy, Charite, Skin Cancer Center Charite, University Hospital of Berlin, Chariteplatz 1, D 10117 Berlin, Germany
    J Virol Methods 146:1-4. 2007
    ..Six beta-HPV types were added successfully to the typing format of the BGC-PCR/RLB system. The potential role of these types in the development of non-melanoma skin cancer awaits further studies...
  8. ncbi request reprint Low prevalence of p53, p16(INK4a) and Ha-ras tumour-specific mutations in low-graded actinic keratosis
    I Nindl
    Department of Dermatology, Charite, Skin Cancer Center Charite, University Hospital of Berlin, Berlin, Germany
    Br J Dermatol 156:34-9. 2007
    ..Different mutation rates of p53, p16(INK4a) and Ha-ras in cutaneous squamous cell carcinoma (SCC) and the earlier stage actinic keratosis (AK) have been reported...
  9. ncbi request reprint High sensitivity and reproducibility of immunohistochemistry with microagitation
    Ingo Nindl
    Charite, Department of Dermatology, 10117 Berlin, Germany
    Arch Dermatol Res 296:278-81. 2004
    ..Microagitation can be used for immunohistochemistry; it was reproducible, highly sensitive, and antibodies could be used at higher dilutions. Further analyses with other antibodies using this technique are warranted...
  10. ncbi request reprint Assessment of TGF-beta1-mediated growth inhibition of HPV-16- and HPV-18-transfected foreskin keratinocytes during and following immortalization
    Ingo Nindl
    Department of Pathology, Section of Molecular Pathology, Vrije Universiteit Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
    Arch Dermatol Res 295:297-304. 2003
    ..Therefore, alternative events are likely to underlie unresponsiveness to TGF- beta1 in late-passage FK16A and FK18B cells...
  11. ncbi request reprint Human papillomavirus and overexpression of P16INK4a in nonmelanoma skin cancer
    Ingo Nindl
    Charite, University of Berlin, Department of Dermatology, Berlin, Germany
    Dermatol Surg 30:409-14. 2004
    ..P16INK4a overexpression has been identified as a specific biomarker in high-risk human papillomavirus (HPV)-infected cervical (pre)cancer lesions...
  12. ncbi request reprint Tenascin-C patterns and splice variants in actinic keratosis and cutaneous squamous cell carcinoma
    C Dang
    Department of Dermatology, Charite, Skin Cancer Center Charite, University Hospital of Berlin, Berlin, Germany
    Br J Dermatol 155:763-70. 2006
    ..The mRNA expression and protein level of Tn-C including its various isoforms have not been investigated comprehensively so far in cutaneous squamous cell carcinoma (SCC) and the precursor lesion actinic keratosis (AK)...
  13. doi request reprint High viral load of human wart-associated papillomaviruses (PV) but not beta-PV in cutaneous warts independent of immunosuppression
    A Kohler
    Charite, Department of Dermatology, Venereology and Allergy, Skin Cancer Center Charite, University Hospital of Berlin, Berlin, Germany
    Br J Dermatol 161:528-35. 2009
    ..A broad spectrum of human papillomaviruses (HPV) has been detected in warts from immunocompetent patients and a much more diverse range from immunosuppressed organ transplant recipients (OTR)...
  14. ncbi request reprint Successful treatment of multiple actinic keratoses in organ transplant patients with topical 5% imiquimod: a report of six cases
    C Ulrich
    Department of Dermatology, University of Humboldt, Schittenhelmstrasse 7, Berlin, Germany
    Br J Dermatol 155:451-4. 2006
    ..Impaired wound healing and high recurrence rates in immunocompromised patients treated with destructive therapies such as cryosurgery or topical 5-fluorouracil represent frequently known complications...
  15. ncbi request reprint Cutaneous precancers in organ transplant recipients: an old enemy in a new surrounding
    C Ulrich
    Department of Dermatology, University Hospital Charite, Schumannstrasse 20 21, D 10117, Berlin, Germany
    Br J Dermatol 149:40-2. 2003
    ..As reduction of the immunosuppressive therapy is rarely practicable, other terms of prophylaxis and treatment, such as immune response modifiers, have to be considered...
  16. doi request reprint Multicenter study of the association between betapapillomavirus infection and cutaneous squamous cell carcinoma
    Jan Nico Bouwes Bavinck
    Department of Dermatology, Leiden University Medical Center, Leiden, The Netherlands
    Cancer Res 70:9777-86. 2010
    ..These combined data support the hypothesis that betaPV may play a role in the development of cutaneous squamous cell carcinoma...
  17. doi request reprint [Human papillomavirus-associated warts in organ transplant recipients. Incidence, risk factors, management]
    D Krüger-Corcoran
    Klinik fur Dermatologie, Venerologie und Allergologie, Hauttumorcentrum Charité HTCC, Universitatsmedizin Berlin, Chariteplatz 1, 10117, Berlin
    Hautarzt 61:220-9. 2010
    ..The challenging management of warts in organ transplantation patients is reviewed...
  18. ncbi request reprint E6/E7 expression of human papillomavirus types in cutaneous squamous cell dysplasia and carcinoma in immunosuppressed organ transplant recipients
    C Dang
    Department of Dermatology, Charite, Skin Cancer Center Charite, University Hospital of Berlin, Chariteplatz 1, D 10117 Berlin, Germany
    Br J Dermatol 155:129-36. 2006
    ..DNA of cutaneous human papillomavirus (HPV) types is frequently found in nonmelanoma skin cancer, and their E6 and E7 proteins can have transforming properties...
  19. ncbi request reprint The role of apoptosis in therapy and prophylaxis of epithelial tumours by nonsteroidal anti-inflammatory drugs (NSAIDs)
    L F Fecker
    Department of Dermatology, Charite, Skin Cancer Center Charite, University Hospital of Berlin, Berlin, Germany
    Br J Dermatol 156:25-33. 2007
    ..Detailed analysis of apoptosis pathways employed by diclofenac in these cells may help to improve therapeutic strategies and to overcome possible mechanisms that are involved in nonresponsiveness...
  20. ncbi request reprint Isolation and genomic characterization of the first Norway rat (Rattus norvegicus) papillomavirus and its phylogenetic position within Pipapillomavirus, primarily infecting rodents
    Eric Schulz
    Clinic for Dermatology, Venereology and Allergology, Skin Cancer Center Charité HTCC, Charite Universitatsmedizin Berlin, Berlin, Germany
    J Gen Virol 90:2609-14. 2009
    ..However, the derived Neogene origin of the genus Pipapillomavirus is much younger than has been considered for the Rodentia as the primary hosts, indicating that alternative interpretations of the phylogenetic trees should be conceived...
  21. doi request reprint Molecular concepts of virus infections causing skin cancer in organ transplant recipients
    I Nindl
    DKFZ Charité Cooperation, Viral Skin Carcinogenesis, German Cancer Research Center, Heidelberg, Germany
    Am J Transplant 8:2199-204. 2008
    ..Moreover, we describe a rodent model system useful to examine future strategies in preventing skin tumor formation in immunosuppressed OTR...
  22. doi request reprint Cutaneous human papillomavirus E7 type-specific effects on differentiation and proliferation of organotypic skin cultures
    K Westphal
    Department of Dermatology, Venereology and Allergy, Charite, Skin Cancer Center Charite, University Hospital of Berlin, Berlin, Germany
    Cell Oncol 31:213-26. 2009
    ..Here we have investigated the effects of E7 expression on keratinocyte differentiation, proliferation and cell-cycle proteins in organotypic skin cultures...
  23. pmc Keratotic skin lesions and other risk factors are associated with skin cancer in organ-transplant recipients: a case-control study in The Netherlands, United Kingdom, Germany, France, and Italy
    Jan N Bouwes Bavinck
    Department of Dermatology, Leiden University Medical Center, Leiden, The Netherlands
    J Invest Dermatol 127:1647-56. 2007
    ....
  24. pmc Development of a general-primer-PCR-reverse-line-blotting system for detection of beta and gamma cutaneous human papillomaviruses
    Antoinette A T P Brink
    Department of Pathology, VU Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
    J Clin Microbiol 43:5581-7. 2005
    ....
  25. ncbi request reprint Identification of dysregulated genes in cutaneous squamous cell carcinoma
    Chantip Dang
    Department of Dermatology, Charite, Skin Cancer Center Charite, University Hospital of Berlin, Berlin, Germany
    Oncol Rep 16:513-9. 2006
    ..02), while RPL15 and LGTN were down-regulated (p < 0.03). The genes differentially expressed during skin carcinogenesis may prove useful in order to understand the origin and progression of cutaneous SCC and for diagnostic approaches...
  26. ncbi request reprint Human papillomaviruses in transplant-associated skin cancers
    Eggert Stockfleth
    Department of Dermatology, Charite, University of Berlin, Germany
    Dermatol Surg 30:604-9. 2004
    ..Human papillomavirus (HPV) infection has been suggested to be involved in the development of nonmelanoma skin cancer, the most common malignancy after solid-organ transplantation...
  27. doi request reprint Genomic characterization of a novel human papillomavirus (HPV-117) with a high viral load in a persisting wart
    Anja Köhler
    Charite, Department of Dermatology, Venereology and Allergy, Skin Cancer Center Charite, University Hospital of Berlin, Berlin, Germany
    Virology 399:129-33. 2010
    ..The high viral load in dysplastic cells of a Verruca vulgaris was shown by in situ hybridization. Our results suggest an active role of the novel type in the development of cutaneous warts of OTR...
  28. ncbi request reprint Phylogenetic analysis of beta-papillomaviruses as inferred from nucleotide and amino acid sequence data
    Marc Gottschling
    Department of Dermatology, Charite, Skin Cancer Center Charite, University Hospital of Berlin, Chariteplatz 1, D 10117 Berlin, Germany
    Mol Phylogenet Evol 42:213-22. 2007
    ..Thus, host and virus phylogenies were not congruent in beta-papillomaviruses, and multiple invasions across species borders may contribute (additionally to host-linked evolution) to their diversification...
  29. ncbi request reprint Viral warts in organ transplant recipients: new aspects in therapy
    T Schmook
    Department of Dermatology, University Hospital Charite, Schumannstrasse 20 21, D 10117 Berlin, Germany
    Br J Dermatol 149:20-4. 2003
    ..A promising novel therapeutic agent is imiquimod, an immune response modifier. Clinical efficacy of imiquimod has been observed for different skin lesions, including viral warts in both immunocompetent and immunosuppressed patients...
  30. doi request reprint Genomic characterization of the first insectivoran papillomavirus reveals an unusually long, second non-coding region and indicates a close relationship to Betapapillomavirus
    Eric Schulz
    Clinic for Dermatology, Venereology and Allergology, Skin Cancer Center Charité HTCC, Charite Universitatsmedizin Berlin, Berlin, Germany
    J Gen Virol 90:626-33. 2009
    ..Our results underscore the modular organization of the PV genome and the complex natural history of PV...
  31. doi request reprint Cutaneotropic human beta-/gamma-papillomaviruses are rarely shared between family members
    Marc Gottschling
    Department of Dermatology, Venereology and Allergy, Charite, Skin Cancer Center Charite, University Hospital of Berlin, Berlin, Germany
    J Invest Dermatol 129:2427-34. 2009
    ..Cutaneotropic HPV types are occasionally exchanged between family members during the entire lifetime, but other donors should also be considered in viral transmission...
  32. ncbi request reprint Multiple evolutionary mechanisms drive papillomavirus diversification
    Marc Gottschling
    Skin Cancer Center Charite, University Hospital of Berlin, Berlin, Germany
    Mol Biol Evol 24:1242-58. 2007
    ..The molecular data globally supports a complex evolutionary scenario for PVes, which is driven by multiple mechanisms but not exclusively by coevolution with corresponding hosts...
  33. doi request reprint Antibody responses to 26 skin human papillomavirus types in the Netherlands, Italy and Australia
    Tim Waterboer
    Department of Genome Modifications and Carcinogenesis, Infections and Cancer Program, German Cancer Research Center, Heidelberg, Germany
    J Gen Virol 90:1986-98. 2009
    ....
  34. doi request reprint Novel papillomavirus isolates from Erinaceus europaeus (Erinaceidae, Insectivora) and the Cervidae (Artiodactyla), Cervus timorensis and Pudu puda, and phylogenetic analysis of partial sequence data
    Marc Gottschling
    Klinik fur Dermatologie, Charite, Haut Tumor Centrum Charité, Universitätskrankenhaus Berlin, Berlin, Germany
    Virus Genes 36:281-7. 2008
    ....
  35. ncbi request reprint Human papillomavirus-16 is the predominant type etiologically involved in penile squamous cell carcinoma
    Daniëlle A M Heideman
    Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands
    J Clin Oncol 25:4550-6. 2007
    ..Therefore, we performed molecular and serologic analyses for a broad spectrum of HPV types on a large series of 83 penile SCCs, and we compared serological findings to those of age-matched male controls (N = 83)...
  36. ncbi request reprint Skin infections in organ transplant recipients
    Claas Ulrich
    Department of Dermatology, Allergy, Venereology, Charite University Hospital, Berlin, Germany
    J Dtsch Dermatol Ges 6:98-105. 2008
    ..Dermatological care of organ transplant recipients using appropriate diagnostic methods adapted to the modified clinical pattern may lead to early adequate treatment...
  37. ncbi request reprint Correlation of p16INK4A overexpression with human papillomavirus infection in cervical adenocarcinomas
    Mitsuya Ishikawa
    Department of Obstetrics, Keio University School of Medicine, Tokyo, Japan
    Int J Gynecol Pathol 22:378-85. 2003
    ..Overexpression of p16INK4a may be an indicator of pathogenic activity of high-risk HPVs...
  38. doi request reprint A novel rodent papillomavirus isolated from anogenital lesions in its natural host
    Julia Nafz
    Applied Tumorvirology, Division Viral Transformation Mechanisms, German Cancer Research Center, Heidelberg, Germany
    Virology 374:186-97. 2008
    ..To date, McPV2 is the first rodent papillomavirus found in anogenital lesions...
  39. ncbi request reprint Human papillomavirus-DNA loads in actinic keratoses exceed those in non-melanoma skin cancers
    Soenke Jan Weissenborn
    Institute of Virology, University of Cologne, Koeln, Germany
    J Invest Dermatol 125:93-7. 2005
    ..Although a passenger state cannot be excluded, the data are compatible with a carcinogenic role of HPV in early steps of tumor development...
  40. ncbi request reprint Persistence of Mastomys natalensis papillomavirus in multiple organs identifies novel targets for infection
    Julia Nafz
    Forschungsschwerpunkt Angewandte Tumorvirologie, Abteilung Virale Transformationsmechanismen, Deutsches Krebsforschungszentrum DKFZ, Heidelberg, Germany
    J Gen Virol 88:2670-8. 2007
    ..coucha is not only useful to study papillomavirus-induced skin carcinogenesis, but may also serve as a model to identify additional, still unknown target cells of papillomavirus infections and the potential pathological impact...