Bodo Niggemann

Summary

Affiliation: Humboldt University
Country: Germany

Publications

  1. ncbi request reprint Atopy Patch Test (APT)--its role in diagnosis of food allergy in atopic dermatitis
    Bodo Niggemann
    Department of Pneumology and Immunology, University Children s Hospital, Charité of Humboldt University, Berlin, Germany
    Indian J Pediatr 69:57-9. 2002
  2. ncbi request reprint An 11-yr-old male with pneumonia and persistent airway obstruction
    B Niggemann
    Dept of Paediatric Pneumology and Immunology, University Hospital Charite, Humboldt University, Berlin, Germany
    Eur Respir J 19:582-4. 2002
  3. ncbi request reprint Specific IgE levels do not indicate persistence or transience of food allergy in children with atopic dermatitis
    B Niggemann
    Dept of Pneumology and Immunology, University Children s Hospital Charité of Humboldt University, Berlin, Germany
    J Investig Allergol Clin Immunol 14:98-103. 2004
  4. ncbi request reprint Evolving role of the atopy patch test in the diagnosis of food allergy
    Bodo Niggemann
    Department of Pneumology and Immunology, University Children s Hospital Charité of Humboldt University, Berlin, Germany
    Curr Opin Allergy Clin Immunol 2:253-6. 2002
  5. ncbi request reprint Anaphylactic reaction to lychee in a 12-year-old girl: cross-reactivity to latex?
    B Niggemann
    Department of Pediatric Pneumology and Immunology, University Children s Hospital, Charité of Humboldt University, Berlin, Germany
    Pediatr Allergy Immunol 13:64-7. 2002
  6. pmc Who should manage infants and young children with food induced symptoms?
    B Niggemann
    Department of Paediatric Pneumology and Immunology, University Children s Hospital Charite, Berlin, Germany
    Arch Dis Child 91:379-82. 2006
  7. ncbi request reprint Does unconventional medicine work through conventional modes of action?
    Bodo Niggemann
    Department of Pediatric Pneumology and Immunology, University Children s Hospital Charite, Humboldt University, Berlin, Germany
    J Allergy Clin Immunol 118:569-73. 2006
  8. ncbi request reprint Diagnosis of food allergy in children: toward a standardization of food challenge
    Bodo Niggemann
    Department of Pediatric Pneumology and Immunology, University Children s Hospital Charité of Humboldt University, Berlin, Germany
    J Pediatr Gastroenterol Nutr 45:399-404. 2007
  9. ncbi request reprint How to enter the pediatric airway for bronchoscopy
    Bodo Niggemann
    Department of Pediatric Pneumology and Immunology, University Hospital Charite of Humboldt University, Berlin, Germany
    Pediatr Int 46:117-21. 2004
  10. ncbi request reprint Sensitizing capacity and residual allergenicity of hydrolyzed cow's milk formulae: results from a murine model
    B Niggemann
    Department of Pneumology and Immunology, University Children s Hospital, Humboldt University, Augustenburger Platz 1, D 13353 Berlin, Germany
    Int Arch Allergy Immunol 125:316-21. 2001

Detail Information

Publications108 found, 100 shown here

  1. ncbi request reprint Atopy Patch Test (APT)--its role in diagnosis of food allergy in atopic dermatitis
    Bodo Niggemann
    Department of Pneumology and Immunology, University Children s Hospital, Charité of Humboldt University, Berlin, Germany
    Indian J Pediatr 69:57-9. 2002
    ..35 kU/l and egg = 17.5 kU/l) makes DBPCFC superfluous for suspected milk and egg allergy. However, several open questions indicate the need for further studies...
  2. ncbi request reprint An 11-yr-old male with pneumonia and persistent airway obstruction
    B Niggemann
    Dept of Paediatric Pneumology and Immunology, University Hospital Charite, Humboldt University, Berlin, Germany
    Eur Respir J 19:582-4. 2002
  3. ncbi request reprint Specific IgE levels do not indicate persistence or transience of food allergy in children with atopic dermatitis
    B Niggemann
    Dept of Pneumology and Immunology, University Children s Hospital Charité of Humboldt University, Berlin, Germany
    J Investig Allergol Clin Immunol 14:98-103. 2004
    ..The aim of the study was to evaluate whether specific IgE levels in serum could be a useful predictor of the outcome of oral re-challenges...
  4. ncbi request reprint Evolving role of the atopy patch test in the diagnosis of food allergy
    Bodo Niggemann
    Department of Pneumology and Immunology, University Children s Hospital Charité of Humboldt University, Berlin, Germany
    Curr Opin Allergy Clin Immunol 2:253-6. 2002
    ..However, several open questions indicate the need for further studies...
  5. ncbi request reprint Anaphylactic reaction to lychee in a 12-year-old girl: cross-reactivity to latex?
    B Niggemann
    Department of Pediatric Pneumology and Immunology, University Children s Hospital, Charité of Humboldt University, Berlin, Germany
    Pediatr Allergy Immunol 13:64-7. 2002
    ..In conclusion, it seems worthwhile considering the rare allergy to lychee in the case of unclear food-allergic reactions and lychee should be added to the list of foods cross-reacting with latex...
  6. pmc Who should manage infants and young children with food induced symptoms?
    B Niggemann
    Department of Paediatric Pneumology and Immunology, University Children s Hospital Charite, Berlin, Germany
    Arch Dis Child 91:379-82. 2006
  7. ncbi request reprint Does unconventional medicine work through conventional modes of action?
    Bodo Niggemann
    Department of Pediatric Pneumology and Immunology, University Children s Hospital Charite, Humboldt University, Berlin, Germany
    J Allergy Clin Immunol 118:569-73. 2006
    ..This might demystify the aura of some of the complementary and alternative approaches and might help to bring both conventional and unconventional approaches together on a scientific basis...
  8. ncbi request reprint Diagnosis of food allergy in children: toward a standardization of food challenge
    Bodo Niggemann
    Department of Pediatric Pneumology and Immunology, University Children s Hospital Charité of Humboldt University, Berlin, Germany
    J Pediatr Gastroenterol Nutr 45:399-404. 2007
    ..Efforts to standardize oral food challenges to achieve the best possible decision on a diet are important to avoid an unnecessary diet that may be harmful to the child...
  9. ncbi request reprint How to enter the pediatric airway for bronchoscopy
    Bodo Niggemann
    Department of Pediatric Pneumology and Immunology, University Hospital Charite of Humboldt University, Berlin, Germany
    Pediatr Int 46:117-21. 2004
    ..Bronchoscopies are performed in childhood for diagnostic reasons (e.g. evaluation of stridor, unexplained cough, possible malformations) and therapeutic reasons (e.g. foreign body removal, management of the difficult airway)...
  10. ncbi request reprint Sensitizing capacity and residual allergenicity of hydrolyzed cow's milk formulae: results from a murine model
    B Niggemann
    Department of Pneumology and Immunology, University Children s Hospital, Humboldt University, Augustenburger Platz 1, D 13353 Berlin, Germany
    Int Arch Allergy Immunol 125:316-21. 2001
    ..The aim of this study was to assess the sensitizing capacity and residual allergenicity of various partially and extensively hydrolyzed cow's milk formulae in a murine model of cow's milk allergy...
  11. doi request reprint Safety and efficacy of a new extensively hydrolyzed formula for infants with cow's milk protein allergy
    B Niggemann
    Department of Pediatric Pneumology and Immunology, University Children s Hospital Charite, Berlin, Germany
    Pediatr Allergy Immunol 19:348-54. 2008
    ..Infants-fed eHF had significantly fewer incidents of vomiting than infants-fed AAF and a significantly higher frequency of soft stools. The new eHF is safe and well tolerated in infants diagnosed with CMPA...
  12. ncbi request reprint Prospective, controlled, multi-center study on the effect of an amino-acid-based formula in infants with cow's milk allergy/intolerance and atopic dermatitis
    B Niggemann
    Department of Pediatric Pneumology and Immunology, Children s Hospital Charité, Humboldt University, Augustenburger Platz 1, D 13353 Berlin, Germany
    Pediatr Allergy Immunol 12:78-82. 2001
    ..Feeding an AA resulted in improved growth compared with feeding eHF, despite similar dietary intakes, and may therefore be considered as a beneficial alternative in infants with severe cow's milk allergy intolerance...
  13. doi request reprint Paediatric allergy diagnosis in primary care is improved by in vitro allergen-specific IgE testing
    Bodo Niggemann
    Department of Pediatric Pneumology and Immunology, Children s Hospital Charité, Berlin, Germany
    Pediatr Allergy Immunol 19:325-31. 2008
    ..The reason why IgE test results were not fully exploited needs to be further scrutinized...
  14. ncbi request reprint Perennial allergen sensitisation early in life and chronic asthma in children: a birth cohort study
    Sabina Illi
    Department of Pediatric Pneumology and Immunology, Charite Universitatsmedizin Berlin, Germany
    Lancet 368:763-70. 2006
    ..Unknown factors between birth and school age determine the progressive loss of pulmonary function in children with persistent asthma. We investigated the role of allergic sensitisation and allergen exposure early in life...
  15. ncbi request reprint The natural course of atopic dermatitis from birth to age 7 years and the association with asthma
    Sabina Illi
    Department of Pediatric Pneumology and Immunology, Charite, Dr von Haunersches Kinderspital, Lindwurmastrasse 4, 80337 Munich, Germany
    J Allergy Clin Immunol 113:925-31. 2004
    ..Atopic dermatitis (AD) is considered to be one of the first manifestations in the atopic march. However, few prospective studies on AD and its association with childhood asthma exist...
  16. ncbi request reprint Association study of Glutathione S-transferase P1 (GSTP1) with asthma and bronchial hyper-responsiveness in two German pediatric populations
    Renate Nickel
    Department of Pediatric Pneumonology and Immunology, Charite, Humboldt University, Berlin, Germany
    Pediatr Allergy Immunol 16:539-41. 2005
    ..We conclude from our data that polymorphisms within GSTP1 do not play a major role in the development of bronchial asthma in German children...
  17. ncbi request reprint Messages from the German Multicentre Allergy Study
    Renate Nickel
    Department for Pediatric Pneumology and Immunology, Charite, Berlin, Germany
    Pediatr Allergy Immunol 13:7-10. 2002
    ..Furthermore, candidate gene studies of atopic dermatitis and increased total serum IgE levels on chromosomes 5q, 12q and 17q in MAS-children and their parents are outlined...
  18. ncbi request reprint The atopy patch test in the diagnostic workup of suspected food-related symptoms in children
    Anne Mehl
    Department of Pediatric Pneumology and Immunology, University Children s Hospital Charite, Berlin, Germany
    J Allergy Clin Immunol 118:923-9. 2006
    ..There is an increasing need to develop test instruments that make oral food challenges superfluous...
  19. ncbi request reprint No association of histamine- N-methyltransferase polymorphism with asthma or bronchial hyperresponsiveness in two German pediatric populations
    Philipp Deindl
    Department of Pediatric Pneumology and Immunology, Charite Humboldt University, Berlin, Germany
    Pediatr Allergy Immunol 16:40-2. 2005
    ..We conclude that this SNP might not play a major role in the pathogenesis of asthma or BHR in German children...
  20. ncbi request reprint Acupuncture in patients with seasonal allergic rhinitis: a randomized trial
    Benno Brinkhaus
    Charité University Medical Center and German Red Cross Hospital Westend, Berlin, Germany
    Ann Intern Med 158:225-34. 2013
    ..Chinese translation..
  21. doi request reprint Walnut allergy in peanut-allergic patients: significance of sequential epitopes of walnut homologous to linear epitopes of Ara h 1, 2 and 3 in relation to clinical reactivity
    Leonard Rosenfeld
    Department of Pediatric Pneumology and Immunology, University Children s Hospital Charite, Berlin, Germany
    Int Arch Allergy Immunol 157:238-45. 2012
    ..Therefore, we analyzed the binding of specific IgE antibodies to sequential epitopes of peanut and walnut in peanut-allergic patients with and without walnut allergy...
  22. pmc The role of polymorphisms in ADAM33, a disintegrin and metalloprotease 33, in childhood asthma and lung function in two German populations
    Michaela Schedel
    University Children s Hospital, Ludwig Maximilian s University Munich, Germany
    Respir Res 7:91. 2006
    ..Thus, we tried to further elucidate the role of ADAM33 polymorphisms (SNPs) in a genetic analysis of German case control and longitudinal populations...
  23. ncbi request reprint The development of childhood asthma: lessons from the German Multicentre Allergy Study (MAS)
    Susanne Lau
    University Children s Hospital, Department of Pneumology and Immunology Berlin, Charite Campus Virchow, Augustenburger Platz 1, 13353 Berlin, Germany
    Paediatr Respir Rev 3:265-72. 2002
    ....
  24. ncbi request reprint The predictive value of specific immunoglobulin E levels in serum for the outcome of oral food challenges
    S Celik-Bilgili
    Department of Pediatric Pneumology and Immunology, University Children s Hospital Charité of Humboldt University, DE 13353 Berlin, Germany
    Clin Exp Allergy 35:268-73. 2005
    ..Specific serum IgE is considered as one of the important diagnostic measures in the diagnostic work-up of food allergy...
  25. ncbi request reprint The predictive value of the skin prick test weal size for the outcome of oral food challenges
    A Verstege
    Department of Pediatric Pneumology and Immunology, University Children s Hospital Charité of Humboldt University, Augustenburger Platz 1, 13353 Berlin, Germany
    Clin Exp Allergy 35:1220-6. 2005
    ....
  26. ncbi request reprint Histamine challenges discriminate between symptomatic and asymptomatic children. MAS-Study Group. Multicentre Allergy Study
    B Niggemann
    Dept of Pediatric Pneumology, , Berlin, Germany
    Eur Respir J 17:246-53. 2001
    ..Provocation protocols for histamine challenges in this age group should therefore start with concentrations markedly below 1.0 mg x mL(-1)...
  27. ncbi request reprint Extraordinarily high serum IgE levels and consequences for atopic phenotypes
    Nora Laske
    Department of Pediatric Pneumology and Immunology, Charite, Humboldt University, Berlin, Germany
    Ann Allergy Asthma Immunol 91:202-4. 2003
    ..IgE plays a central role in allergic diseases. Recent studies have postulated an association between serum IgE levels and bronchial asthma...
  28. ncbi request reprint Polymorphisms in eosinophil pathway genes, asthma and atopy
    M Kabesch
    University Children s Hospital, Ludwig Maximilians University Munich, Munich, Germany
    Allergy 62:423-8. 2007
    ....
  29. ncbi request reprint Atopy patch tests, together with determination of specific IgE levels, reduce the need for oral food challenges in children with atopic dermatitis
    C C Roehr
    Department of Pneumology and Immunology, , Berlin, Germany
    J Allergy Clin Immunol 107:548-53. 2001
    ..35 kU/L; HE, > or = 17.5 kU/L) makes double-blind, placebo-controlled, food challenges superfluous for suspected CM and HE allergy...
  30. ncbi request reprint Specific oral tolerance induction with food in children: transient or persistent effect on food allergy?
    C Rolinck-Werninghaus
    Department of Pediatric Pneumology and Immunology, University Children s Hospital Charité of Humboldt University, Berlin, Germany
    Allergy 60:1320-2. 2005
    ..We report on a subset of three patients of a larger ongoing study who were treated successfully with SOTI treatment, but experienced a secondary loss of tolerance after a period of allergen avoidance...
  31. pmc A randomised multicentre trial of acupuncture in patients with seasonal allergic rhinitis - trial intervention including physician and treatment characteristics
    Miriam Ortiz
    Institute of Social Medicine, Epidemiology and Health Economics, Charite Universitatsmedizin Berlin, Berlin, Germany
    BMC Complement Altern Med 14:128. 2014
    ....
  32. ncbi request reprint The value of specific IgE to peanut and its component Ara h 2 in the diagnosis of peanut allergy
    Lucila C Lopes de Oliveira
    Department of Pediatric Pneumology and Immunology, Charite Universitatsmedizin Berlin, Berlin, Germany Division of Allergy and Clinical Immunology, Department of Pediatrics, Federal University of Sao Paulo, Sao Paulo, Brazil
    J Allergy Clin Immunol Pract 1:394-8. 2013
    ..To avoid unnecessary oral food challenges, which are time consuming, stressful, and risky, improved in vitro diagnostic methods for food allergy such as component resolved diagnostics are still under investigation...
  33. doi request reprint History of respiratory infections in the first 12 yr among children from a birth cohort
    Christoph Gruber
    Department of Pediatric Pneumology and Immunology, Charite Universitatsmedizin Berlin, Berlin, Germany
    Pediatr Allergy Immunol 19:505-12. 2008
    ..Episodes within these reference values per se should not cause unwarranted concern or intervention because of suspected immunodeficiency...
  34. ncbi request reprint Does the severity of atopic dermatitis correlate with serum IgE levels?
    Nora Laske
    Department of Pediatric Pneumology and Immunology, Charite, Humboldt University, Augustenburger Platz 1, 13353 Berlin, Germany
    Pediatr Allergy Immunol 15:86-8. 2004
    ..These results suggest that serum IgE levels seem to correlate with the degree of eczema. Children with severe atopic dermatitis and high IgE levels are at risk for sensitization to food allergens and aeroallergens...
  35. pmc Early childhood infectious diseases and the development of asthma up to school age: a birth cohort study
    S Illi
    Department of Pulmonology and Allergology, University Children s Hospital, Lindwurmstrasse 4, 80337 Munich, Germany
    BMJ 322:390-5. 2001
    ..To investigate the association between early childhood infections and subsequent development of asthma...
  36. ncbi request reprint Longitudinal study on the relationship between cat allergen and endotoxin exposure, sensitization, cat-specific IgG and development of asthma in childhood--report of the German Multicentre Allergy Study (MAS 90)
    S Lau
    Department of Pediatric Pneumology and Immunology, Charité Medical University, Berlin, Germany
    Allergy 60:766-73. 2005
    ....
  37. ncbi request reprint Food allergy and non-allergic food hypersensitivity in children and adolescents
    C C Roehr
    Department of Pediatric Pneumology and Immunology, University Hospital Charite, Humboldt University, Berlin, Germany
    Clin Exp Allergy 34:1534-41. 2004
    ..Little information is available on the prevalence of food hypersensitivity in unselected paediatric populations. No data were available for German children...
  38. ncbi request reprint Importance of chamber size for the outcome of atopy patch testing in children with atopic dermatitis and food allergy
    Bodo Niggemann
    Department of Pneumology and Immunology, University Children s Hospital Charité of Humboldt University, Berlin, Germany
    J Allergy Clin Immunol 110:515-6. 2002
    ..Therefore, 12-mm cups should be used for atopy patch tests with food, even in infants and small children...
  39. doi request reprint Differential diagnosis of food-induced symptoms
    Birgit Ahrens
    Department of Pediatric Pneumology and Immunology, Charite Universitatsmedizin Berlin, Berlin, Germany
    Pediatr Allergy Immunol 19:92-6. 2008
    ....
  40. doi request reprint Oral peanut immunotherapy in children with peanut anaphylaxis
    Katharina Blumchen
    Department of Pediatric Pneumology and Immunology, University Hospital Charite, Berlin, Germany
    J Allergy Clin Immunol 126:83-91.e1. 2010
    ..The only treatment option for peanut allergy is strict avoidance...
  41. ncbi request reprint Proposal for a standardized interpretation of the atopy patch test in children with atopic dermatitis and suspected food allergy
    Ralf G Heine
    Department of Pediatric Pneumology and Immunology, Children s Hospital Charité, Humboldt University, Berlin, Germany
    Pediatr Allergy Immunol 17:213-7. 2006
    ..Presence of both induration and of at least seven papules at 72 h were the APT skin signs with the greatest diagnostic accuracy for food allergy in children with AD...
  42. ncbi request reprint Clara cell protein 16 (CC16) gene polymorphism influences the degree of airway responsiveness in asthmatic children
    Claudia Sengler
    Department of Pediatric Pneumology and Immunology, Charite Humboldt University, Berlin, Germany
    J Allergy Clin Immunol 111:515-9. 2003
    ..CC16 is expressed in the bronchial epithelium and exhibits potent anti-inflammatory properties. A single-nucleotide polymorphism (SNP) in the CC16 gene (A38G) was previously associated with asthma...
  43. ncbi request reprint Specific oral tolerance induction in food allergy in children: efficacy and clinical patterns of reaction
    U Staden
    Department of Pediatric Pneumology and Immunology, University Children s Hospital Charite, Berlin, Germany
    Allergy 62:1261-9. 2007
    ..Specific oral tolerance induction (SOTI) seems to be a promising treatment of food allergy. Specific oral tolerance induction and elimination diet were compared with respect to efficacy rate and patterns of clinical reaction...
  44. ncbi request reprint Utility of the ratio of food-specific IgE/total IgE in predicting symptomatic food allergy in children
    A Mehl
    Department of Pediatric Pneumology and Immunology, University Children s Hospital Charité of Humboldt University, Berlin, Germany
    Allergy 60:1034-9. 2005
    ..Double-blind, placebo-controlled food challenges are time-consuming, expensive and not without risk to patients. Therefore, an in vitro test that could accurately diagnose food allergy would be of great value...
  45. ncbi request reprint The pattern of atopic sensitization is associated with the development of asthma in childhood
    S Illi
    Department of Pediatric Pneumology and Immunology, , Berlin, Germany
    J Allergy Clin Immunol 108:709-14. 2001
    ..CONCLUSION: Our results indicate that an underlying factor pertaining to asthma and maternal transmission may determine both a certain pattern of sensitization and the expression of asthma...
  46. ncbi request reprint Modified oral food challenge used with sensitization biomarkers provides more real-life clinical thresholds for peanut allergy
    Katharina Blumchen
    Department of Pediatric Pneumology and Immunology, Charite Universitatsmedizin Berlin, Berlin, Germany Electronic address
    J Allergy Clin Immunol 134:390-398.e4. 2014
    ..Threshold levels for peanut allergy determined by using oral challenges are important for the food industry with regard to allergen labeling. Moreover, the utility of biological markers in predicting threshold levels is uncertain...
  47. ncbi request reprint Effects of established allergen sensitization on immune and airway responses after secondary allergen sensitization
    Katharina Blumchen
    Department of Pediatric Pneumology and Immunology, University Hospital Charite, Berlin
    J Allergy Clin Immunol 118:615-21. 2006
    ..Spreading of sensitization with clinical manifestation of allergy is often observed in atopic individuals...
  48. ncbi request reprint Frequency of atopic dermatitis and relevance of food allergy in adults in Germany
    Margitta Worm
    Allergy Centre Charité, Department of Dermatology and Allergy, Charite Universitatsmedizin Berlin, D 10117 Berlin, Germany
    Acta Derm Venereol 86:119-22. 2006
    ..A non-selected AD patient cohort does not frequently suffer from clinically relevant pollen-associated food allergy...
  49. ncbi request reprint Lack of detectable alterations in immune responses during sublingual immunotherapy in children with seasonal allergic rhinoconjunctivitis to grass pollen
    C Rolinck-Werninghaus
    Department of Pediatric Pneumology and Immunology, Charite, Berlin, Germany
    Int Arch Allergy Immunol 136:134-41. 2005
    ..There are few data on sublingual immunotherapy (SLIT), especially in children...
  50. ncbi request reprint Variability of total serum immunoglobulin E levels from birth to the age of 10 years. A prospective evaluation in a large birth cohort (German Multicenter Allergy Study)
    R Nickel
    Department of Pediatric Pneumology and Immunology, Charite, Humboldt University, Berlin, Germany
    Clin Exp Allergy 35:619-23. 2005
    ..Multiple genetic studies on tIgE regulation have been performed. For these population-based studies tIgE was commonly determined at one time-point, assuming that tIgE phenotypes (adjusted for age and gender) are stable over time...
  51. ncbi request reprint Five-year follow-up on the PAT study: specific immunotherapy and long-term prevention of asthma in children
    B Niggemann
    Department of Pediatric Pneumology and Immunology, Charite, Berlin, Germany
    Allergy 61:855-9. 2006
    ..To investigate the long-term preventive effect, we performed a follow up--2 years after termination of immunotherapy...
  52. doi request reprint Effects of latex avoidance on latex sensitization, atopy and allergic diseases in patients with spina bifida
    K Blumchen
    Department of Pediatric Pneumology and Immunology, Charite University Medicine, Berlin, Germany
    Allergy 65:1585-93. 2010
    ..Ten years ago, avoidance measures such as the performance of latex-free operations were implemented in children with spina bifida. Since then, latex sensitization and latex allergy have decreased in this high-risk group...
  53. ncbi request reprint Comparison of bronchial responsiveness to histamine in asthma, allergic rhinitis and allergic sensitization at the age of 7 years
    R Nickel
    Department of Pediatric Pneumology and Immunology, Charite Humboldt University, Berlin, Germany
    Clin Exp Allergy 32:1274-7. 2002
    ..Bronchial responsiveness (BR) to histamine or methacholin is a common finding in adult non-asthmatic patients with allergic rhinitis...
  54. doi request reprint Primary versus secondary immunoglobulin E sensitization to soy and wheat in the Multi-Centre Allergy Study cohort
    P M Matricardi
    Department of Pediatric Pneumology and Immunology, Charité University Medical Centre, Berlin, Germany
    Clin Exp Allergy 38:493-500. 2008
    ..The age-specific relevance of these categories of sensitization throughout childhood is unknown...
  55. ncbi request reprint Primary prevention of allergy: avoiding risk or providing protection?
    E Hamelmann
    Department of Pediatric Pneumology and Immunology, Charite, Universitatsmedizin, Berlin, Germany
    Clin Exp Allergy 38:233-45. 2008
    ..This shifting of allergy prevention research from avoidance to tolerance induction will hopefully allow us to reverse the epidemic trend of allergy diseases...
  56. ncbi request reprint A prospective, randomized, double-blind, placebo-controlled multi-centre study on the efficacy and safety of sublingual immunotherapy (SLIT) in children with seasonal allergic rhinoconjunctivitis to grass pollen
    C Rolinck-Werninghaus
    Department of Pediatric Pneumology and Immunology, Charite, Berlin, Germany
    Allergy 59:1285-93. 2004
    ..Especially in childhood, sublingual immunotherapy (SLIT) could offer advantages over subcutaneous therapy. However, limited data on its efficacy is available...
  57. ncbi request reprint Transient early wheeze is not associated with impaired lung function in 7-yr-old children
    S Lau
    Dept of Paediatric Pneumology and Immunology, Charite, Humboldt University, Berlin, Germany
    Eur Respir J 21:834-41. 2003
    ..Although transient early wheezers were found to have normal-to-subnormal lung function, children with asthmatic symptoms (persistent and late-onset disease) at age 7 yrs already show significant impairment of expiratory flow volumes...
  58. ncbi request reprint Dynamic evolution of serum immunoglobulin E to airborne allergens throughout childhood: results from the Multi-Centre Allergy Study birth cohort
    P M Matricardi
    Department of Pediatric Pneumology and Immunology, Charite Universitatsmedizin, Berlin, Germany
    Clin Exp Allergy 39:1551-7. 2009
    ..Allergic rhinoconjunctivitis and asthma evolve dynamically throughout childhood. Yet, data on the evolution of serum levels of IgE antibodies against airborne allergens throughout the first decade of life are scarce...
  59. ncbi request reprint How should a birth cohort study be organised? Experience from the German MAS cohort study
    Renate Nickel
    University Children s Hospital, Department of Pneumology and Immunology, Charite Campus Virchow, Augustenburger Platz 1, 13353 Berlin, Germany
    Paediatr Respir Rev 3:169-76. 2002
    ....
  60. ncbi request reprint Acupuncture in seasonal allergic rhinitis (ACUSAR)--design and protocol of a randomised controlled multi-centre trial
    Benno Brinkhaus
    Institute for Social Medicine, Epidemiology, and Health Economics, Charite University Medical Center, Berlin, Germany
    Forsch Komplementmed 17:95-102. 2010
    ..We report on the study design and protocol of a randomised controlled trial (Acupuncture in Seasonal Allergic Rhinitis, ACUSAR) that investigates the efficacy of acupuncture in the treatment of seasonal allergic rhinitis (SAR)...
  61. doi request reprint IgE-mediated latex allergy--an exciting and instructive piece of allergy history
    Bodo Niggemann
    Pediatric Allergology and Pneumology, German Red Cross Clinic Westend, Berlin, Germany
    Pediatr Allergy Immunol 21:997-1001. 2010
    ....
  62. ncbi request reprint Life-threatening vallecular cyst in a 3-month-old infant: case report and literature review
    Birgit Ahrens
    Department of Pediatric Pneumology and Immunology, Charite, Humboldt University, Berlin, Germany
    Clin Pediatr (Phila) 43:287-90. 2004
  63. ncbi request reprint Predictors of positive food challenge outcome in non-IgE-mediated reactions to food in children with atopic dermatitis
    B Niggemann
    Department of Pneumology and Immunology, , Berlin, Germany
    J Allergy Clin Immunol 108:1053-8. 2001
    ..Otherwise, some children will not receive diagnoses for food allergy and be denied the benefits of a specific diet...
  64. ncbi request reprint Clinical usefulness of microarray-based IgE detection in children with suspected food allergy
    H Ott
    Department of Dermatology and Allergology, Charite Universitatsmedizin Berlin, Berlin, Germany
    Allergy 63:1521-8. 2008
    ..The aim of this study was to evaluate the utility of microarray-based IgE detection in the diagnostic workup of food allergy and to compare this new diagnostic tool with established methods of allergen-specific IgE detection...
  65. ncbi request reprint Controlled oral food challenges in children--when indicated, when superfluous?
    B Niggemann
    Department of Pediatric Pneumology and Immunology, University Children s Hospital Charité of Humboldt University, Berlin, Germany
    Allergy 60:865-70. 2005
    ..In this article, the current knowledge of predictors for the outcome of oral food challenges is reviewed and proposals for the daily practical work-up in the case of suspected food related clinical symptoms are presented...
  66. doi request reprint Maternal smoking increases risk of allergic sensitization and wheezing only in children with allergic predisposition: longitudinal analysis from birth to 10 years
    T Keil
    Institute for Social Medicine, Epidemiology, and Health Economics, Charite University Medical Center, Berlin, Germany
    Allergy 64:445-51. 2009
    ..To examine the interaction of passive smoking and an allergic predisposition regarding allergic sensitization, allergic airway symptoms and respiratory infections during the first 10 years of life...
  67. ncbi request reprint Skin prick test with hen's egg: whole egg or egg white?
    K Perackis
    Department of Pediatric Pneumology and Immunology, Children s Hospital Charité, Humboldt University, Augustenburger Platz 1 D 13353, Berlin, Germany
    Allergy 59:1236-7. 2004
  68. ncbi request reprint Unproven diagnostic procedures in IgE-mediated allergic diseases
    B Niggemann
    Department of Pediatric Pneumology and Immunology, University Children s Hospital Charite, Humboldt University, Augustenburger Platz 1, D 13353 Berlin, Germany
    Allergy 59:806-8. 2004
    ..Ineffective diagnostic approaches may be costly for the consumer and delay appropriate therapy...
  69. ncbi request reprint Unconventional and conventional medicine: who should learn from whom?
    Bodo Niggemann
    Department of Pediatric Pneumology and Immunology, University Children s Hospital Charite, Humboldt University, Berlin, Germany
    Pediatr Allergy Immunol 14:149-55. 2003
    ..Chances and risks of unconventional methods are discussed. However, only by considering controlled studies can conventional and unconventional diagnostic and therapeutic methods be advocated on the basis of evidence rather than ideology...
  70. ncbi request reprint Functional symptoms confused with allergic disorders in children and adolescents
    Bodo Niggemann
    Department of Pneumology and Immunology, University Children s Hospital Charité of Humboldt University, Berlin, Germany
    Pediatr Allergy Immunol 13:312-8. 2002
    ....
  71. ncbi request reprint Small toys contained in chocolate eggs--good or bad surprise?
    Rainer Kehrt
    Department of Paediatric Pneumology and Immunology, Virchow Klinikum, Humboldt University, Berlin, Germany
    Respir Med 96:955-6. 2002
  72. ncbi request reprint Condoms are not a risk factor for sensitization to latex
    Frank Chih Kang Chen
    Department of Obstetrics, Charite, Campus Virchow Clinic of Humboldt University, Berlin, Germany
    Contraception 66:439-41. 2002
    ..Latex-free condoms should only be recommended to women already known to be sensitized to latex...
  73. ncbi request reprint Diagnostic pitfalls in food allergy in children
    B Niggemann
    Department of Pediatric Pneumology and Immunology, University Children s Hospital Charité of Humboldt University, Berlin, Germany
    Allergy 60:104-7. 2005
    ....
  74. ncbi request reprint Role of oral food challenges in the diagnostic work-up of food allergy in atopic eczema dermatitis syndrome
    B Niggemann
    Department of Pediatric Pneumology and Immunology, University Children s Hospital Charité of Humboldt University, Berlin, Germany
    Allergy 59:32-4. 2004
    ..The effort involved in such a procedure is justified because it can help to avoid clinically relevant food allergens in some cases and in others can prevent children from being exposed unnecessarily to diets that may be harmful to them...
  75. ncbi request reprint Prevalence of adverse reactions to food in Germany - a population study
    T Zuberbier
    Department of Dermatology and Allergy, University Hospital Charite, Humboldt University, Germany
    Allergy 59:338-45. 2004
    ..A population study was performed to identify the prevalence of all kinds of adverse reactions to food...
  76. doi request reprint The multinational birth cohort of EuroPrevall: background, aims and methods
    T Keil
    Institute for Social Medicine, Epidemiology and Health Economics, Charite University Medical Center, Berlin, Germany
    Allergy 65:482-90. 2010
    ..This protocol describes the specific aims and diagnostic protocol of a birth cohort study examining prevalence patterns and influential factors of confirmed food allergies in European children from different regions...
  77. ncbi request reprint Treatment of allergic alveolitis with methylprednisolone pulse therapy
    Christiane Chen
    Department of Paediatric Pneumology and Immunology, Charite, Humboldt University, Berlin, Germany
    Pediatr Allergy Immunol 14:66-70. 2003
    ..It is estimated that the effect of a single pulse lasted for at least 2-4 weeks. We conclude that pulse therapy can be used instead of continuous therapy in this rare disease in childhood...
  78. doi request reprint How to diagnose psychogenic and functional breathing disorders in children and adolescents
    Bodo Niggemann
    Pediatric Allergology and Pneumology, German Red Cross Clinic Westend, Berlin, Germany
    Pediatr Allergy Immunol 21:895-9. 2010
    ....
  79. ncbi request reprint Primary ciliary dyskinesia associated with normal axoneme ultrastructure is caused by DNAH11 mutations
    Georg C Schwabe
    Department for General Pediatrics, Charite University Hospital, Campus Virchow, Berlin, Germany
    Hum Mutat 29:289-98. 2008
    ....
  80. ncbi request reprint Asymmetric evolution of pulmonary interstitial emphysema in a preterm newborn infant
    Ute Staden
    Department of Pediatric Pneumology and Immunology, Charite Virchow Hospital, Humboldt University, Berlin, Germany
    Pediatr Int 46:487-9. 2004
  81. ncbi request reprint When is an oral food challenge positive?
    Bodo Niggemann
    Pediatric Allergology and Pneumology, Hedwig von Rittberg Centre, German Red Cross Clinic Westend, Berlin, Germany
    Allergy 65:2-6. 2010
    ....
  82. ncbi request reprint Prevalence of latex-specific IgE antibodies in atopic and nonatopic children with type I diabetes
    T Danne
    Children s Hospital, Charite Virchow Clinic, Humboldt University, Berlin, Germany
    Diabetes Care 20:476-8. 1997
    ..The potential induction of allergic sensitization to latex from insulin vial tops stimulated an investigation of the prevalence of specific IgE antibodies to latex in serum and the relationship to atopic disease in children with diabetes...
  83. ncbi request reprint Early atopic disease and early childhood immunization--is there a link?
    C Gruber
    Department of Pediatric Pneumology and Immunology, Charite Universitatsmedizin, Berlin, Germany
    Allergy 63:1464-72. 2008
    ..The study assessed the effect of vaccine immunization before the first birthday on eczema severity and allergic sensitization in the second year of life...
  84. ncbi request reprint Side-effects of complementary and alternative medicine
    B Niggemann
    Department of Pediatric Pneumology and Immunology, University Children s Hospital Charite, Humboldt University, Berlin, Germany
    Allergy 58:707-16. 2003
    ..Therefore, caution may be justified using both conventional and unconventional methods. Only if the benefit is proven and the side-effects are established, should a given method be chosen...
  85. ncbi request reprint [Allergen immunotherapy - a position paper of the German society for allergology and clinical immunology]
    J Kleine-Tebbe
    Arbeitsgruppe Spezifische Immuntherapie der Sektion Immunologie der DGAI, Berlin, Germany
    Pneumologie 55:438-44. 2001
    ..Modified allergens, recombinant proteins and immunomodulatory adjuvants created by basic research are promises for an improved efficacy of AIT with reduced unwanted effects in the future...
  86. ncbi request reprint Specific oral tolerance induction in food allergy
    B Niggemann
    Department of Pediatric Pneumology and Immunology, University Children s Hospital Charite, Berlin, Germany
    Allergy 61:808-11. 2006
    ..However, before SOTI can be recommended for the daily praxis, more studies are warranted to clarify whether certain patients may profit from SOTI and to understand the underlying mechanism...
  87. ncbi request reprint Pitfalls in double-blind, placebo-controlled oral food challenges
    B Niggemann
    Department of Pediatric Pneumology and Immunology, University Children s Hospital Charite, Berlin, Germany
    Allergy 62:729-32. 2007
    ..On the contrary, the possible relation of DBPCFC and SOTI may offer potential advantages for future therapeutic approaches of food allergy...
  88. ncbi request reprint Effect of freezing foods for the outcome of skin prick tests
    M Ziegert
    Department of Pediatric Pneumology and Immunology, University Children s Hospital Charite, Augustenburger Platz 1, 13353 Berlin, Germany
    Allergy 62:818-9. 2007
  89. ncbi request reprint Anaphylactic reactions in children--a questionnaire-based survey in Germany
    A Mehl
    Department of Pediatric Pneumology and Immunology, Charite University Medical Center Berlin, Berlin, Germany
    Allergy 60:1440-5. 2005
    ..Severe anaphylactic reactions are medical emergencies requiring immediate recognition and treatment. Despite this, little is known on their clinical features, especially in infants and children...
  90. ncbi request reprint Randomized, placebo-controlled trial of Lactobacillus rhamnosus GG as treatment of atopic dermatitis in infancy
    C Gruber
    Department of Pediatric Pneumology and Immunology, Universitatsmedizin Berlin, Charite, Berlin, Germany
    Allergy 62:1270-6. 2007
    ..This study was designed to investigate the therapeutic effect of Lactobacillus rhamnosus GG (LGG) as a food supplement in infants suffering from atopic dermatitis...
  91. ncbi request reprint Latex allergy in pediatric surgery is dependent on repeated operations in the first year of life
    P Degenhardt
    Department of Pediatric Surgery, , Berlin, Germany
    J Pediatr Surg 36:1535-9. 2001
    ..CONCLUSION: This study emphasizes that individuals undergoing surgical interventions during infancy should be handled latex free from the very beginning of life...
  92. ncbi request reprint A practical approach to immunization in atopic children
    Christoph Gruber
    Department of Pediatric Pneumology and Immunology, Charite Humboldt University, Berlin, Germany
    Allergy 57:472-9. 2002
  93. ncbi request reprint Christmas surprise: the unnoticed journey of a needle-from bronchus to intestine
    H Graffstädt
    Department of Pediatric Surgery, University Children s Hospital Charite, Berlin, Germany
    Respir Med 99:1600-2. 2005
    ..It also reminds the physician to diagnose aspirated foreign bodies as early as possible to prevent wandering and migrating, which may induce new risks and unnecessary diagnostic and therapeutic procedures...
  94. ncbi request reprint Influence of age on the outcome of the atopy patch test with food in children with atopic dermatitis
    Katharina Perackis
    J Allergy Clin Immunol 112:625-7. 2003
  95. ncbi request reprint The cradle of IgE autoreactivity in atopic eczema lies in early infancy
    Nadine Mothes
    J Allergy Clin Immunol 116:706-9. 2005
  96. doi request reprint Dietary prevention of allergic diseases in infants and small children
    Arne Høst
    Department of Pediatrics, Odense University Hospital, Odense, Denmark
    Pediatr Allergy Immunol 19:1-4. 2008
    ....
  97. ncbi request reprint Dietary prevention of allergic diseases in infants and small children. Part II. Evaluation of methods in allergy prevention studies and sensitization markers. Definitions and diagnostic criteria of allergic diseases
    Antonella Muraro
    Department of Pediatrics, University of Padua, Padua, Italy
    Pediatr Allergy Immunol 15:196-205. 2004
    ..This survey include target group for dietary prevention and methods and diagnostic criteria of atopic dermatitis, asthma and food allergy for prevention studies...
  98. ncbi request reprint Dietary prevention of allergic diseases in infants and small children. Part III: Critical review of published peer-reviewed observational and interventional studies and final recommendations
    Antonella Muraro
    Department of Pediatrics, University of Padua, Padua, Italy
    Pediatr Allergy Immunol 15:291-307. 2004
    ..In the absence of breast milk, formulas with documented reduced allergenicity for at least 4-6 months should be used...
  99. doi request reprint The role of wheat omega-5 gliadin IgE antibodies as a diagnostic tool for wheat allergy in childhood
    Kirsten Beyer
    J Allergy Clin Immunol 122:419-21. 2008
  100. ncbi request reprint Immunoglobulin E-reactivity of wheat-allergic subjects (baker's asthma, food allergy, wheat-dependent, exercise-induced anaphylaxis) to wheat protein fractions with different solubility and digestibility
    Diana Mittag
    Paul Ehrlich Institut, Langen, Germany
    Mol Nutr Food Res 48:380-9. 2004
    ..However, ethanol-soluble gliadins were stable to gastric enzymes and exhibit low solubility in gastric and duodenal fluids. Therefore, they are likely to be important in food allergy to wheat...
  101. ncbi request reprint Evolution of IgM, IgE and IgG(1-4 )antibody responses in early childhood monitored with recombinant allergen components: implications for class switch mechanisms
    Verena Niederberger
    Department of Otorhinolaryngology, Vienna General Hospital, University of Vienna, Waeringer Guertel 18 20, A 1090 Vienna, Austria
    Eur J Immunol 32:576-84. 2002
    ....