H Monnikes

Summary

Affiliation: Humboldt University
Country: Germany

Publications

  1. ncbi request reprint Neuropeptide Y in the paraventricular nucleus of the hypothalamus stimulates colonic transit by peripheral cholinergic and central CRF pathways
    H Monnikes
    Department of Internal Medicine, Philipps University of Marburg, Marburg, Germany
    Neurogastroenterol Motil 12:343-52. 2000
  2. ncbi request reprint Novel measurement of rapid treatment success with ReQuest: first and sustained symptom relief as outcome parameters in patients with endoscopy-negative GERD receiving 20 mg pantoprazole or 20 mg esomeprazole
    Hubert Monnikes
    Department of Medicine, Division Hepatology, Gastroenterology, and Endocrinology, Charité Medical Center Campus Virchow Hospital, Medical School of Free University and Humboldt University, Berlin, Germany
    Digestion 75:62-8. 2007
  3. ncbi request reprint Evaluation of GERD symptoms during therapy. Part II. Psychometric evaluation and validation of the new questionnaire ReQuest in erosive GERD
    H Monnikes
    Charite, Berlin, Germany
    Digestion 75:41-7. 2007
  4. ncbi request reprint Gastric electrical stimulation in gastroparesis: where do we stand?
    Hubert Monnikes
    Department of Medicine, Division of Hepatology, Gastroenterology, and Endocrinology, Campus Virchow Klinikum, Charite Universitatsmedizin Berlin, Berlin, Germany
    Dig Dis 24:260-6. 2006
  5. ncbi request reprint Novel measurement of rapid treatment success with ReQuest: first and sustained symptom relief as outcome parameters in patients with endoscopy-negative GERD receiving 20 mg pantoprazole or 20 mg esomeprazole
    Hubert Monnikes
    Department of Medicine, Division Hepatology, Charité Medical Center Campus Virchow Hospital, Medical School of Free University and Humboldt University, Augustenburgerplatz 1, DE 13353 Berlin, Germany
    Digestion 71:152-8. 2005
  6. ncbi request reprint Gastric perception thresholds are low and sensory neuropeptide levels high in helicobacter pylori-positive functional dyspepsia
    Hubert Monnikes
    Department of Medicine, Division of Hepatology and Gastroenterology, Charite, Campus Virchow Klinikum, Humboldt Universitat zu Berlin, Germany
    Digestion 71:111-23. 2005
  7. ncbi request reprint Evaluation of GERD symptoms during therapy. Part II. Psychometric evaluation and validation of the new questionnaire ReQuest in erosive GERD
    H Monnikes
    Department of Medicine, Charite, Freie Universitat, DE 13353 Berlin, Germany
    Digestion 69:238-44. 2004
  8. ncbi request reprint Differential induction of c-fos expression in brain nuclei by noxious and non-noxious colonic distension: role of afferent C-fibers and 5-HT3 receptors
    Hubert Monnikes
    Department of Internal Medicine, Charite, Humboldt Universitat, Berlin, Germany
    Brain Res 966:253-64. 2003
  9. ncbi request reprint [Increasing the dose, evaluating compliance, revising the diagnosis. Prescriptions for apparently resistant processes in the esophagus]
    H Monnikes
    Medizinische Klinik, Universitatsklinikum Charite, Berlin
    MMW Fortschr Med 142:39-42. 2000
  10. ncbi request reprint Involvement of CCK in the paraventricular nucleus of the hypothalamus in the CNS regulation of colonic motility
    H Monnikes
    Department of Internal Medicine, Philipps University of Marburg, Germany
    Digestion 62:178-84. 2000

Collaborators

Detail Information

Publications38

  1. ncbi request reprint Neuropeptide Y in the paraventricular nucleus of the hypothalamus stimulates colonic transit by peripheral cholinergic and central CRF pathways
    H Monnikes
    Department of Internal Medicine, Philipps University of Marburg, Marburg, Germany
    Neurogastroenterol Motil 12:343-52. 2000
    ..The effect of NPY in the PVN on colonic motor function depends on central CRF and peripheral cholinergic pathways...
  2. ncbi request reprint Novel measurement of rapid treatment success with ReQuest: first and sustained symptom relief as outcome parameters in patients with endoscopy-negative GERD receiving 20 mg pantoprazole or 20 mg esomeprazole
    Hubert Monnikes
    Department of Medicine, Division Hepatology, Gastroenterology, and Endocrinology, Charité Medical Center Campus Virchow Hospital, Medical School of Free University and Humboldt University, Berlin, Germany
    Digestion 75:62-8. 2007
    ..Therefore, this study investigated the efficacy of 20 mg pantoprazole and 20 mg esomeprazole with regard to the time to symptom relief in patients with endoscopy-negative GERD (enGERD) using ReQuest...
  3. ncbi request reprint Evaluation of GERD symptoms during therapy. Part II. Psychometric evaluation and validation of the new questionnaire ReQuest in erosive GERD
    H Monnikes
    Charite, Berlin, Germany
    Digestion 75:41-7. 2007
    ..We therefore developed the Reflux Questionnaire (ReQuest). This publication describes the psychometric evaluation and validation of ReQuest...
  4. ncbi request reprint Gastric electrical stimulation in gastroparesis: where do we stand?
    Hubert Monnikes
    Department of Medicine, Division of Hepatology, Gastroenterology, and Endocrinology, Campus Virchow Klinikum, Charite Universitatsmedizin Berlin, Berlin, Germany
    Dig Dis 24:260-6. 2006
    ..Gastric electric stimulation presents a new possibility in the treatment of gastroparesis...
  5. ncbi request reprint Novel measurement of rapid treatment success with ReQuest: first and sustained symptom relief as outcome parameters in patients with endoscopy-negative GERD receiving 20 mg pantoprazole or 20 mg esomeprazole
    Hubert Monnikes
    Department of Medicine, Division Hepatology, Charité Medical Center Campus Virchow Hospital, Medical School of Free University and Humboldt University, Augustenburgerplatz 1, DE 13353 Berlin, Germany
    Digestion 71:152-8. 2005
    ..Therefore, this study investigated the efficacy of 20 mg pantoprazole and 20 mg esomeprazole with regard to the time to symptom relief in patients with endoscopy-negative GERD (enGERD) using ReQuest...
  6. ncbi request reprint Gastric perception thresholds are low and sensory neuropeptide levels high in helicobacter pylori-positive functional dyspepsia
    Hubert Monnikes
    Department of Medicine, Division of Hepatology and Gastroenterology, Charite, Campus Virchow Klinikum, Humboldt Universitat zu Berlin, Germany
    Digestion 71:111-23. 2005
    ..The aim of this study was to assess whether FD patients have altered mucosal concentrations of CGRP and SP, and to investigate whether this is associated with visceral hypersensitivity or H. pylori infection...
  7. ncbi request reprint Evaluation of GERD symptoms during therapy. Part II. Psychometric evaluation and validation of the new questionnaire ReQuest in erosive GERD
    H Monnikes
    Department of Medicine, Charite, Freie Universitat, DE 13353 Berlin, Germany
    Digestion 69:238-44. 2004
    ..We therefore developed the Reflux Questionnaire (ReQuest). This publication describes the psychometric evaluation and validation of ReQuest...
  8. ncbi request reprint Differential induction of c-fos expression in brain nuclei by noxious and non-noxious colonic distension: role of afferent C-fibers and 5-HT3 receptors
    Hubert Monnikes
    Department of Internal Medicine, Charite, Humboldt Universitat, Berlin, Germany
    Brain Res 966:253-64. 2003
    ....
  9. ncbi request reprint [Increasing the dose, evaluating compliance, revising the diagnosis. Prescriptions for apparently resistant processes in the esophagus]
    H Monnikes
    Medizinische Klinik, Universitatsklinikum Charite, Berlin
    MMW Fortschr Med 142:39-42. 2000
    ..In any case of resistance to treatment, it is recommended that the diagnosis be checked, and the algorithms on how to proceed issued by the specialist associations (re-)consulted...
  10. ncbi request reprint Involvement of CCK in the paraventricular nucleus of the hypothalamus in the CNS regulation of colonic motility
    H Monnikes
    Department of Internal Medicine, Philipps University of Marburg, Germany
    Digestion 62:178-84. 2000
    ..The data suggest, that endogenous CCK in the paraventricular nucleus of the hypothalamus unfolds a stimulatory effect on colonic transit through action on CCK-B receptors...
  11. ncbi request reprint Electrogastrography as a diagnostic tool for delayed gastric emptying in functional dyspepsia and irritable bowel syndrome
    I R van der Voort
    Department of Medicine, Division Hepatology, Gastroenterology, Endocrinology, and Metabolic Diseases, Charite, Campus Virchow Klinikum, Humboldt Universitat zu Berlin, Berlin, Germany
    Neurogastroenterol Motil 15:467-73. 2003
    ..The data suggest that EGG could be useful as a diagnostic tool in patients with FD and IBS to identify a subgroup of patients with delayed gastric emptying...
  12. ncbi request reprint Role of stress in functional gastrointestinal disorders. Evidence for stress-induced alterations in gastrointestinal motility and sensitivity
    H Monnikes
    Department of Medicine, Division of Hepatology and Gastroenterology, Universitatsklinikum Charite, Campus Virchow Klinikum, Humboldt Universitat zu Berlin, Augustenburger Platz 1, D 13353 Berlin, Germany
    Dig Dis 19:201-11. 2001
    ..g. the amygdala. Stress-induced activation or sensitization of mucosal mast cells in the GI tract seem to be involved in stress-associated alterations of visceral sensitivity...
  13. pmc Anti-ghrelin Spiegelmer NOX-B11 inhibits neurostimulatory and orexigenic effects of peripheral ghrelin in rats
    P Kobelt
    Department of Medicine, Division of Hepatology, Gastroenterology, and Endocrinology, Charite School of Medicine, Campus Virchow Klinikum, Berlin, Germany
    Gut 55:788-92. 2006
    ..Spiegelmer NOX-B11 is a synthetic l-oligonucleotide, which was previously shown to bind ghrelin. We examined the effects of NOX-B11 on ghrelin induced neuronal activation and food intake in non-fasted rats...
  14. ncbi request reprint Eating disorders: a role for dipeptidyl peptidase IV in nutritional control
    M Hildebrandt
    Department of Internal Medicine, Charite Campus Virchow Klinikum, Humboldt Universitat zu Berlin, Berlin, Germany
    Nutrition 17:451-4. 2001
    ..The potential impact of an increase in DPP IV activity in serum on satiety and nutrition control contributes to previously reported implications for immune function...
  15. ncbi request reprint The complete remission concept
    Hubert Monnikes
    Division of Hepatology, Gastroenterology and Endocrinology, Charite University Medical Center, Campus Virchow, Berlin, Germany
    Drugs Today (Barc) 42:9-14. 2006
    ..The new ReQuest(TM)/ LA-classification enables the detailed clinical characterization of GERD patients at any stage and accurate assessment of treatment outcome by a single global measure...
  16. ncbi request reprint Cocaine- and amphetamine-regulated transcript stimulates colonic motility via central CRF receptor activation and peripheral cholinergic pathways in fed, conscious rats
    J J Tebbe
    Division of Gastroenterology and Endocrinology, Department of Internal Medicine, Philipps Universitat Marburg, Baldinger Strasse 1, 35033 Marburg, Germany
    Neurogastroenterol Motil 16:489-96. 2004
    ..The results suggest that CART acts in the central nervous system to modulate behavioural motor function via a central CRF receptor-dependent mechanism and peripheral cholinergic pathways...
  17. ncbi request reprint Long-term failure of endoscopic suturing in the treatment of gastroesophageal reflux: a prospective follow-up study
    H Abou-Rebyeh
    Department of Hepatology and Gastroenterology, Charite Universitatsmedizin Berlin, Campus Virchow Klinikum, Humboldt University, Augustenburger Platz 1, 13353 Berlin, Germany
    Endoscopy 37:213-6. 2005
    ..This report presents prospective 1-year follow-up results, including technical, clinical, and functional success rates, for the first of these treatments to be developed, endoscopic gastroplication (EGP)...
  18. ncbi request reprint Subjective theories of illness and clinical and psychological outcomes in patients with irritable bowel syndrome
    Andrea Riedl
    Division of Hepatology, Gastroenterology, and Endocrinology, Department of Medicine, Charite Universitatsmedizin Berlin, Campus Virchow, Berlin, Germany
    J Psychosom Res 67:449-55. 2009
    ..The aim of the study was to investigate patients' subjective theories of illness and how these are related to clinical and psychological outcome criteria, in particular IBS symptom severity and quality of life...
  19. doi request reprint Serotonin transporter activity and serotonin concentration in platelets of patients with irritable bowel syndrome: effect of gender
    Leonora Franke
    Department of Psychiatry and Psychotherapy, Charite Universitatsmedizin Berlin, Campus Charité Mitte CCM, Schumannstr 20 21, 10117 Berlin, Germany
    J Gastroenterol 45:389-98. 2010
    ..However, it is still not clear how SERT contributes to this clinically heterogeneous disease. The present study addressed this issue by implementing platelet (plt) markers of SERT activity in the assessment protocol...
  20. ncbi request reprint T-cell immune parameters and depression in patients with Crohn's disease
    Matthias Rose
    Department of Internal Medicine, Division of Psychosomatics and Psychotherapy, Charite, Campus Virchow Humboldt University Berlin, Berlin, Germany
    J Clin Gastroenterol 34:40-8. 2002
    ....
  21. doi request reprint Randomised clinical trial: sustained response to PPI treatment of symptoms resembling functional dyspepsia and irritable bowel syndrome in patients suffering from an overlap with erosive gastro-oesophageal reflux disease
    H Monnikes
    Department of Medicine, Martin Luther Hospital, Academic Teaching Hospital of Charité Universitätsmedizin, Berlin, Germany
    Aliment Pharmacol Ther 35:1279-89. 2012
    ..Despite availability of a vast body of research related to individual disorders, major pharmacological breakthrough in treatment of the overlap condition is still lacking...
  22. ncbi request reprint Brain activation responses to subliminal or supraliminal rectal stimuli and to auditory stimuli in irritable bowel syndrome
    V Andresen
    Department of Medicine, Division of Hepatology, Gastroenterology, and Endocrinology, Charite Universitatsmedizin Berlin, Berlin, Germany
    Neurogastroenterol Motil 17:827-37. 2005
    ..Hyperreactivity to auditory stimuli suggests that altered sensory processing in IBS may not be restricted to visceral sensation...
  23. ncbi request reprint Dipeptidyl peptidase IV (DP IV, CD26) in patients with inflammatory bowel disease
    M Hildebrandt
    Dept of Psychosomatic Medicine, Humboldt Universitat zu Berlin, Germany
    Scand J Gastroenterol 36:1067-72. 2001
    ..We hypothesized that the activity of DP IV in serum and expression of CD26/DP IV in lymphocytes may be altered in patients with inflammatory bowel disease (IBD)...
  24. ncbi request reprint DPP IV and mental depression in Crohn's disease
    Matthias Rose
    Department of Internal Medicine, Charite, Humboldt University, Luisenstrasse 13a, Berlin, Germany
    Adv Exp Med Biol 524:321-31. 2003
  25. ncbi request reprint Review on the influence of stress on immune mediators, neuropeptides and hormones with relevance for inflammatory bowel disease
    J H Niess
    Biomedizinisches Forschungszentrum, Campus Virchow Klinikum, Berlin, Germany
    Digestion 65:131-40. 2002
    ..e. neurotransmitters, hormones and immune cells, which are involved in the response to stress on the one hand, and contribute to the onset, progression or relapses of IBD on the other...
  26. ncbi request reprint Oesophageal transport of solid dosage forms depends on body position, swallowing volume and pharyngeal propulsion velocity
    E Osmanoglou
    Division of Hepatology and Gastroenterology, Department of Medicine, Charite, Campus Virchow Klinikum, Humboldt Universitat Berlin, Berlin, Germany
    Neurogastroenterol Motil 16:547-56. 2004
    ..Body position, swallowing volume and pharyngeal propulsion velocity markedly influence the oesophageal transport of SDF. They should be taken in upright body position with at least 50 mL of water to minimize entrapment in the oesophagus...
  27. doi request reprint Somatic comorbidities of irritable bowel syndrome: a systematic analysis
    Andrea Riedl
    Division of Hepatology, Gastroenterology, and Endocrinology, Department of Medicine, Charite University Medical Center, Campus Virchow, Berlin, Germany
    J Psychosom Res 64:573-82. 2008
    ....
  28. ncbi request reprint Bombesin, but not amylin, blocks the orexigenic effect of peripheral ghrelin
    Peter Kobelt
    Department of Medicine, Charite Universitatsmedizin Berlin, Germany
    Am J Physiol Regul Integr Comp Physiol 291:R903-13. 2006
    ..4 +/- 0.8% of CRF-immunoreactive neurons in the PVN. These results suggest that peripheral bombesin, unlike amylin, inhibits peripheral ghrelin induced food intake and enhances activation of CRF neurons in the PVN...
  29. ncbi request reprint CCK inhibits the orexigenic effect of peripheral ghrelin
    Peter Kobelt
    Department of Medicine, Division of Hepatology and Gastroenterology, Charite, Medical Faculty of Freie Universität and Humboldt Universität at Berlin, Campus Virchow Klinikum, Augustenburger Platz 1, 13353 Berlin, Germany
    Am J Physiol Regul Integr Comp Physiol 288:R751-8. 2005
    ..These results suggest that CCK abolishes ghrelin-induced food intake through dampening increased ARC neuronal activity...
  30. pmc Peripherally injected CCK-8S activates CART positive neurons of the paraventricular nucleus in rats
    Lisa Peter
    Department of Medicine, Division Hepatology, Gastroenterology, and Endocrinology, Charite, Campus Virchow, Universitatsmedizin Berlin, 10117 Berlin, Germany
    Peptides 31:1118-23. 2010
    ..The present observation shows that CCK-8S injected ip induces an increase in neuronal activity in PVN-CART neurons and suggests that CART neurons in the PVN may play a role in the mediation of peripheral CCK-8S's anorexigenic effects...
  31. ncbi request reprint Intraperitoneal injection of ghrelin induces Fos expression in the paraventricular nucleus of the hypothalamus in rats
    Jens Ruter
    Department of Medicine, Charite, Campus Mitte, Humboldt Universitat, Berlin, Germany
    Brain Res 991:26-33. 2003
    ..Our data suggest that an activation of the arcuate-paraventricular axis may be part of the brain circuits involved in the orexigenic effect of peripheral ghrelin...
  32. ncbi request reprint Two immunocytochemical protocols for immunofluorescent detection of c-Fos positive neurons in the rat brain
    Peter Kobelt
    Department of Medicine, Division Hepatology and Gastroenterology, Charite, Campus Virchow Klinikum, Humboldt Universitat Berlin, Germany
    Brain Res Brain Res Protoc 13:45-52. 2004
    ....
  33. doi request reprint CCK-8S activates c-Fos in a dose-dependent manner in nesfatin-1 immunoreactive neurons in the paraventricular nucleus of the hypothalamus and in the nucleus of the solitary tract of the brainstem
    Steffen Noetzel
    Department of Medicine, Division Hepatology, Gastroenterology, and Endocrinology Charité, Campus Virchow Universitätsmedizin Berlin, Germany
    Regul Pept 157:84-91. 2009
    ..No effect on the number of c-Fos-ir neurons was observed in the ARC. These results suggest that the effects of CCK on the HPA axis and on food intake may, at least in part, be mediated by nesfatin-1-ir neurons in the PVN...
  34. pmc Desacyl ghrelin inhibits the orexigenic effect of peripherally injected ghrelin in rats
    Tobias Inhoff
    Department of Medicine, Division Hepatology, Gastroenterology, and Endocrinology, Charite Universitatsmedizin Berlin, Campus Virchow, Berlin, Germany
    Peptides 29:2159-68. 2008
    ..These results suggest that desacyl ghrelin suppresses ghrelin-induced food intake by curbing ghrelin-induced increased neuronal activity in the arcuate nucleus and recruiting nesfatin-1 immunopositive neurons...
  35. pmc Peripheral obestatin has no effect on feeding behavior and brain Fos expression in rodents
    Peter Kobelt
    Department of Medicine, Division Psychosomatic Medicine and Psychotherapy, Charite Universitatsmedizin Berlin, Campus Charite Mitte, Berlin, Germany
    Peptides 29:1018-27. 2008
    ..Therefore, peripheral obestatin has no effect on FI under various experimental conditions and did not induce Fos in relevant central neuronal circuitries modulating feeding in rodents...
  36. pmc Peripheral injection of ghrelin induces Fos expression in the dorsomedial hypothalamic nucleus in rats
    Peter Kobelt
    Department of Medicine, Division of Hepatology, Gastroenterology, and Endocrinology, Charite, Campus Virchow, Universitatsmedizin Berlin, Germany
    Brain Res 1204:77-86. 2008
    ..These data indicate that peripheral ghrelin activates DMH neurons and that NPY-/AgRP-positive fibers may be involved in the response...
  37. ncbi request reprint Peripheral injection of CCK-8S induces Fos expression in the dorsomedial hypothalamic nucleus in rats
    Peter Kobelt
    Department of Medicine, Division Hepatology, Gastroenterology, and Endocrinology, Charite, Campus Virchow, Humboldt Universitat zu Berlin, Germany
    Brain Res 1117:109-17. 2006
    ..These data indicate that in addition of the PVN, peripheral CCK increases neuronal activity in the DMH suggesting a possible role in this hypothalamic nucleus in the satiating effect of the peptide...
  38. ncbi request reprint Emotional stress reactivity in irritable bowel syndrome
    Dominik R Bach
    Department of Medicine, Division Hepatology and Gastroenterology, Charite, Universitatsmedizin Berlin, Campus Virchow Klinikum, Berlin, Germany
    Eur J Gastroenterol Hepatol 18:629-36. 2006
    ..Research on stress reactivity in IBS has yielded ambiguous results, regarding responses to physical and mental stress. This study aimed to investigate the responses to emotional stress in IBS patients...