Research Topics
| H MonnikesSummaryAffiliation: Humboldt University Country: Germany Publications
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Detail Information
Publications
Neuropeptide Y in the paraventricular nucleus of the hypothalamus stimulates colonic transit by peripheral cholinergic and central CRF pathwaysH Monnikes
Department of Internal Medicine, Philipps University of Marburg, Marburg, Germany
Neurogastroenterol Motil 12:343-52. 2000..The effect of NPY in the PVN on colonic motor function depends on central CRF and peripheral cholinergic pathways...- Novel measurement of rapid treatment success with ReQuest: first and sustained symptom relief as outcome parameters in patients with endoscopy-negative GERD receiving 20 mg pantoprazole or 20 mg esomeprazoleHubert Monnikes
Department of Medicine, Division Hepatology, Gastroenterology, and Endocrinology, Charité Medical Center Campus Virchow Hospital, Medical School of Free University and Humboldt University, Berlin, Germany
Digestion 75:62-8. 2007..Therefore, this study investigated the efficacy of 20 mg pantoprazole and 20 mg esomeprazole with regard to the time to symptom relief in patients with endoscopy-negative GERD (enGERD) using ReQuest... - Evaluation of GERD symptoms during therapy. Part II. Psychometric evaluation and validation of the new questionnaire ReQuest in erosive GERDH Monnikes
Charite, Berlin, Germany
Digestion 75:41-7. 2007..We therefore developed the Reflux Questionnaire (ReQuest). This publication describes the psychometric evaluation and validation of ReQuest... - Gastric electrical stimulation in gastroparesis: where do we stand?Hubert Monnikes
Department of Medicine, Division of Hepatology, Gastroenterology, and Endocrinology, Campus Virchow Klinikum, Charite Universitatsmedizin Berlin, Berlin, Germany
Dig Dis 24:260-6. 2006..Gastric electric stimulation presents a new possibility in the treatment of gastroparesis... - Novel measurement of rapid treatment success with ReQuest: first and sustained symptom relief as outcome parameters in patients with endoscopy-negative GERD receiving 20 mg pantoprazole or 20 mg esomeprazoleHubert Monnikes
Department of Medicine, Division Hepatology, Charité Medical Center Campus Virchow Hospital, Medical School of Free University and Humboldt University, Augustenburgerplatz 1, DE 13353 Berlin, Germany
Digestion 71:152-8. 2005..Therefore, this study investigated the efficacy of 20 mg pantoprazole and 20 mg esomeprazole with regard to the time to symptom relief in patients with endoscopy-negative GERD (enGERD) using ReQuest... - Gastric perception thresholds are low and sensory neuropeptide levels high in helicobacter pylori-positive functional dyspepsiaHubert Monnikes
Department of Medicine, Division of Hepatology and Gastroenterology, Charite, Campus Virchow Klinikum, Humboldt Universitat zu Berlin, Germany
Digestion 71:111-23. 2005..The aim of this study was to assess whether FD patients have altered mucosal concentrations of CGRP and SP, and to investigate whether this is associated with visceral hypersensitivity or H. pylori infection... - Evaluation of GERD symptoms during therapy. Part II. Psychometric evaluation and validation of the new questionnaire ReQuest in erosive GERDH Monnikes
Department of Medicine, Charite, Freie Universitat, DE 13353 Berlin, Germany
Digestion 69:238-44. 2004..We therefore developed the Reflux Questionnaire (ReQuest). This publication describes the psychometric evaluation and validation of ReQuest... - Differential induction of c-fos expression in brain nuclei by noxious and non-noxious colonic distension: role of afferent C-fibers and 5-HT3 receptorsHubert Monnikes
Department of Internal Medicine, Charite, Humboldt Universitat, Berlin, Germany
Brain Res 966:253-64. 2003.... - Involvement of CCK in the paraventricular nucleus of the hypothalamus in the CNS regulation of colonic motilityH Monnikes
Department of Internal Medicine, Philipps University of Marburg, Germany
Digestion 62:178-84. 2000..The data suggest, that endogenous CCK in the paraventricular nucleus of the hypothalamus unfolds a stimulatory effect on colonic transit through action on CCK-B receptors... - [Increasing the dose, evaluating compliance, revising the diagnosis. Prescriptions for apparently resistant processes in the esophagus]H Monnikes
Medizinische Klinik, Universitatsklinikum Charite, Berlin
MMW Fortschr Med 142:39-42. 2000..In any case of resistance to treatment, it is recommended that the diagnosis be checked, and the algorithms on how to proceed issued by the specialist associations (re-)consulted... - Role of stress in functional gastrointestinal disorders. Evidence for stress-induced alterations in gastrointestinal motility and sensitivityH Monnikes
Department of Medicine, Division of Hepatology and Gastroenterology, Universitatsklinikum Charite, Campus Virchow Klinikum, Humboldt Universitat zu Berlin, Augustenburger Platz 1, D 13353 Berlin, Germany
Dig Dis 19:201-11. 2001..g. the amygdala. Stress-induced activation or sensitization of mucosal mast cells in the GI tract seem to be involved in stress-associated alterations of visceral sensitivity... - Eating disorders: a role for dipeptidyl peptidase IV in nutritional controlM Hildebrandt
Department of Internal Medicine, Charite Campus Virchow Klinikum, Humboldt Universitat zu Berlin, Berlin, Germany
Nutrition 17:451-4. 2001..The potential impact of an increase in DPP IV activity in serum on satiety and nutrition control contributes to previously reported implications for immune function... - The complete remission conceptHubert Monnikes
Division of Hepatology, Gastroenterology and Endocrinology, Charite University Medical Center, Campus Virchow, Berlin, Germany
Drugs Today (Barc) 42:9-14. 2006..The new ReQuest(TM)/ LA-classification enables the detailed clinical characterization of GERD patients at any stage and accurate assessment of treatment outcome by a single global measure... - Cocaine- and amphetamine-regulated transcript stimulates colonic motility via central CRF receptor activation and peripheral cholinergic pathways in fed, conscious ratsJ J Tebbe
Division of Gastroenterology and Endocrinology, Department of Internal Medicine, Philipps Universitat Marburg, Baldinger Strasse 1, 35033 Marburg, Germany
Neurogastroenterol Motil 16:489-96. 2004..The results suggest that CART acts in the central nervous system to modulate behavioural motor function via a central CRF receptor-dependent mechanism and peripheral cholinergic pathways... - Long-term failure of endoscopic suturing in the treatment of gastroesophageal reflux: a prospective follow-up studyH Abou-Rebyeh
Department of Hepatology and Gastroenterology, Charite Universitatsmedizin Berlin, Campus Virchow Klinikum, Humboldt University, Augustenburger Platz 1, 13353 Berlin, Germany
Endoscopy 37:213-6. 2005..This report presents prospective 1-year follow-up results, including technical, clinical, and functional success rates, for the first of these treatments to be developed, endoscopic gastroplication (EGP)... - Subjective theories of illness and clinical and psychological outcomes in patients with irritable bowel syndromeAndrea Riedl
Division of Hepatology, Gastroenterology, and Endocrinology, Department of Medicine, Charite Universitatsmedizin Berlin, Campus Virchow, Berlin, Germany
J Psychosom Res 67:449-55. 2009..The aim of the study was to investigate patients' subjective theories of illness and how these are related to clinical and psychological outcome criteria, in particular IBS symptom severity and quality of life... - T-cell immune parameters and depression in patients with Crohn's diseaseMatthias Rose
Department of Internal Medicine, Division of Psychosomatics and Psychotherapy, Charite, Campus Virchow Humboldt University Berlin, Berlin, Germany
J Clin Gastroenterol 34:40-8. 2002.... - Serotonin transporter activity and serotonin concentration in platelets of patients with irritable bowel syndrome: effect of genderLeonora Franke
Department of Psychiatry and Psychotherapy, Charite Universitatsmedizin Berlin, Campus Charité Mitte CCM, Schumannstr 20 21, 10117 Berlin, Germany
J Gastroenterol 45:389-98. 2010..However, it is still not clear how SERT contributes to this clinically heterogeneous disease. The present study addressed this issue by implementing platelet (plt) markers of SERT activity in the assessment protocol... - Randomised clinical trial: sustained response to PPI treatment of symptoms resembling functional dyspepsia and irritable bowel syndrome in patients suffering from an overlap with erosive gastro-oesophageal reflux diseaseH Monnikes
Department of Medicine, Martin Luther Hospital, Academic Teaching Hospital of Charité Universitätsmedizin, Berlin, Germany
Aliment Pharmacol Ther 35:1279-89. 2012..Despite availability of a vast body of research related to individual disorders, major pharmacological breakthrough in treatment of the overlap condition is still lacking... - Dipeptidyl peptidase IV (DP IV, CD26) in patients with inflammatory bowel diseaseM Hildebrandt
Dept of Psychosomatic Medicine, Humboldt Universitat zu Berlin, Germany
Scand J Gastroenterol 36:1067-72. 2001..We hypothesized that the activity of DP IV in serum and expression of CD26/DP IV in lymphocytes may be altered in patients with inflammatory bowel disease (IBD)... - DPP IV and mental depression in Crohn's diseaseMatthias Rose
Department of Internal Medicine, Charit, Humboldt University, Luisenstrasse 13a, Berlin, Germany
Adv Exp Med Biol 524:321-31. 2003 - Somatic comorbidities of irritable bowel syndrome: a systematic analysisAndrea Riedl
Division of Hepatology, Gastroenterology, and Endocrinology, Department of Medicine, Charite University Medical Center, Campus Virchow, Berlin, Germany
J Psychosom Res 64:573-82. 2008.... - Bombesin, but not amylin, blocks the orexigenic effect of peripheral ghrelinPeter Kobelt
Department of Medicine, , Germany
Am J Physiol Regul Integr Comp Physiol 291:R903-13. 2006..4 +/- 0.8% of CRF-immunoreactive neurons in the PVN. These results suggest that peripheral bombesin, unlike amylin, inhibits peripheral ghrelin induced food intake and enhances activation of CRF neurons in the PVN... - Peripheral injection of CCK-8S induces Fos expression in the dorsomedial hypothalamic nucleus in ratsPeter Kobelt
Department of Medicine, Division Hepatology, Gastroenterology, and Endocrinology, Charit, Campus Virchow, , Germany
Brain Res 1117:109-17. 2006..These data indicate that in addition of the PVN, peripheral CCK increases neuronal activity in the DMH suggesting a possible role in this hypothalamic nucleus in the satiating effect of the peptide... - Peripherally injected CCK-8S activates CART positive neurons of the paraventricular nucleus in ratsLisa Peter
Department of Medicine, Division Hepatology, Gastroenterology, and Endocrinology, Charite, Campus Virchow, Universitatsmedizin Berlin, 10117 Berlin, Germany
Peptides 31:1118-23. 2010..The present observation shows that CCK-8S injected ip induces an increase in neuronal activity in PVN-CART neurons and suggests that CART neurons in the PVN may play a role in the mediation of peripheral CCK-8S's anorexigenic effects... - Intraperitoneal injection of ghrelin induces Fos expression in the paraventricular nucleus of the hypothalamus in ratsJens Ruter
Department of Medicine, Charite, Campus Mitte, Humboldt Universitat, Berlin, Germany
Brain Res 991:26-33. 2003..Our data suggest that an activation of the arcuate-paraventricular axis may be part of the brain circuits involved in the orexigenic effect of peripheral ghrelin... - Two immunocytochemical protocols for immunofluorescent detection of c-Fos positive neurons in the rat brainPeter Kobelt
Department of Medicine, Division Hepatology and Gastroenterology, Charit, Campus Virchow-Klinikum, , Germany
Brain Res Brain Res Protoc 13:45-52. 2004.... - CCK-8S activates c-Fos in a dose-dependent manner in nesfatin-1 immunoreactive neurons in the paraventricular nucleus of the hypothalamus and in the nucleus of the solitary tract of the brainstemSteffen Noetzel
Department of Medicine, Division Hepatology, Gastroenterology, and Endocrinology Charité, Campus Virchow Universitätsmedizin Berlin, Germany
Regul Pept 157:84-91. 2009..No effect on the number of c-Fos-ir neurons was observed in the ARC. These results suggest that the effects of CCK on the HPA axis and on food intake may, at least in part, be mediated by nesfatin-1-ir neurons in the PVN... - Desacyl ghrelin inhibits the orexigenic effect of peripherally injected ghrelin in ratsTobias Inhoff
Department of Medicine, Division Hepatology, Gastroenterology, and Endocrinology, Charite Universitatsmedizin Berlin, Campus Virchow, Berlin, Germany
Peptides 29:2159-68. 2008..These results suggest that desacyl ghrelin suppresses ghrelin-induced food intake by curbing ghrelin-induced increased neuronal activity in the arcuate nucleus and recruiting nesfatin-1 immunopositive neurons... - Peripheral obestatin has no effect on feeding behavior and brain Fos expression in rodentsPeter Kobelt
Department of Medicine, Division Psychosomatic Medicine and Psychotherapy, Charite Universitatsmedizin Berlin, Campus Charite Mitte, Berlin, Germany
Peptides 29:1018-27. 2008..Therefore, peripheral obestatin has no effect on FI under various experimental conditions and did not induce Fos in relevant central neuronal circuitries modulating feeding in rodents... - Peripheral injection of ghrelin induces Fos expression in the dorsomedial hypothalamic nucleus in ratsPeter Kobelt
Department of Medicine, Division of Hepatology, Gastroenterology, and Endocrinology, Charite, Campus Virchow, Universitatsmedizin Berlin, Germany
Brain Res 1204:77-86. 2008..These data indicate that peripheral ghrelin activates DMH neurons and that NPY-/AgRP-positive fibers may be involved in the response... - CCK inhibits the orexigenic effect of peripheral ghrelinPeter Kobelt
Department of Medicine, Division of Hepatology and Gastroenterology, Charite, Medical Faculty of Freie Universität and Humboldt Universität at Berlin, Campus Virchow Klinikum, Augustenburger Platz 1, 13353 Berlin, Germany
Am J Physiol Regul Integr Comp Physiol 288:R751-8. 2005..These results suggest that CCK abolishes ghrelin-induced food intake through dampening increased ARC neuronal activity... - Emotional stress reactivity in irritable bowel syndromeDominik R Bach
Department of Medicine, Division Hepatology and Gastroenterology, Charit, , Campus Virchow-Klinikum, Berlin, Germany
Eur J Gastroenterol Hepatol 18:629-36. 2006..IBS patients showed a broader and less specific response to emotional stress than healthy controls. Rectal sensitivity was unchanged under emotional stress both in IBS patients and healthy controls...