F P Mockenhaupt

Summary

Affiliation: Humboldt University
Country: Germany

Publications

  1. pmc High prevalence of Giardia duodenalis Assemblage B infection and association with underweight in Rwandan children
    Ralf Ignatius
    Institute of Tropical Medicine and International Health, Charite University Medicine Berlin, Berlin, Germany
    PLoS Negl Trop Dis 6:e1677. 2012
  2. pmc Type 2 diabetes mellitus and increased risk for malaria infection
    Ina Danquah
    Institute of Tropical Medicine and International Health, Berlin, Germany
    Emerg Infect Dis 16:1601-4. 2010
  3. pmc Mutations of complement lectin pathway genes MBL2 and MASP2 associated with placental malaria
    Ville Holmberg
    Department of Bacteriology and Immunology, University of Helsinki, Helsinki, Finland
    Malar J 11:61. 2012
  4. pmc Diabetes mellitus type 2 in urban Ghana: characteristics and associated factors
    Ina Danquah
    Institute of Tropical Medicine and International Health, Charite University Medicine Berlin, Berlin, Germany
    BMC Public Health 12:210. 2012
  5. pmc Prevalence and risk factors of malaria among children in southern highland Rwanda
    Jean Bosco Gahutu
    Butare University Teaching Hospital, Faculty of Medicine, National University of Rwanda, Butare, Rwanda
    Malar J 10:134. 2011
  6. pmc Multiplicity of Plasmodium falciparum infection following intermittent preventive treatment in infants
    Ulrike Buchholz
    Institute of Tropical Medicine and International Health, Charite University Medicine, Berlin, Germany
    Malar J 9:244. 2010
  7. pmc Efficacy of amodiaquine in the treatment of uncomplicated falciparum malaria in young children of rural north-western Burkina Faso
    Germain Mandi
    Centre de Recherche en Santé de Nouna, Nouna, Burkina Faso
    Malar J 7:58. 2008
  8. pmc Allelic dimorphism of the erythrocyte binding antigen-175 (eba-175) gene of Plasmodium falciparum and severe malaria: Significant association of the C-segment with fatal outcome in Ghanaian children
    Jakob P Cramer
    Berlin Institute of Tropical Medicine, Berlin, Germany
    Malar J 3:11. 2004
  9. pmc Decline of placental malaria in southern Ghana after the implementation of intermittent preventive treatment in pregnancy
    Lena Hommerich
    Institute of Tropical Medicine and International Health, Charite University Medicine, Berlin, Germany
    Malar J 6:144. 2007
  10. pmc Malaria transmission in non-endemic areas: case report, review of the literature and implications for public health management
    Thomas Zoller
    Medizinische Klinik mit Schwerpunkt Infektiologie und Pneumologie, Charite Universitatsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
    Malar J 8:71. 2009

Collaborators

Detail Information

Publications72

  1. pmc High prevalence of Giardia duodenalis Assemblage B infection and association with underweight in Rwandan children
    Ralf Ignatius
    Institute of Tropical Medicine and International Health, Charite University Medicine Berlin, Berlin, Germany
    PLoS Negl Trop Dis 6:e1677. 2012
    ..We aimed at addressing these questions and at examining epidemiological characteristics of G. duodenalis in southern highland Rwanda...
  2. pmc Type 2 diabetes mellitus and increased risk for malaria infection
    Ina Danquah
    Institute of Tropical Medicine and International Health, Berlin, Germany
    Emerg Infect Dis 16:1601-4. 2010
    ..Increase in diabetes mellitus prevalence may put more persons at risk for malaria infection...
  3. pmc Mutations of complement lectin pathway genes MBL2 and MASP2 associated with placental malaria
    Ville Holmberg
    Department of Bacteriology and Immunology, University of Helsinki, Helsinki, Finland
    Malar J 11:61. 2012
    ..Innate immunity plays a crucial role in the host defense against malaria including Plasmodium falciparum malaria in pregnancy, but the roles of the various underlying genes and mechanisms predisposing to the disease are poorly understood...
  4. pmc Diabetes mellitus type 2 in urban Ghana: characteristics and associated factors
    Ina Danquah
    Institute of Tropical Medicine and International Health, Charite University Medicine Berlin, Berlin, Germany
    BMC Public Health 12:210. 2012
    ..In this hospital-based study in Kumasi, Ghana, we aimed at characterizing clinical, anthropometric, socio-economic, nutritional and behavioural parameters of DM2 patients and at identifying associated factors...
  5. pmc Prevalence and risk factors of malaria among children in southern highland Rwanda
    Jean Bosco Gahutu
    Butare University Teaching Hospital, Faculty of Medicine, National University of Rwanda, Butare, Rwanda
    Malar J 10:134. 2011
    ..In the southern highlands, near the district capital of Butare (altitude, 1,768 m), a combined community-and facility-based survey on Plasmodium infection was conducted early in 2010...
  6. pmc Multiplicity of Plasmodium falciparum infection following intermittent preventive treatment in infants
    Ulrike Buchholz
    Institute of Tropical Medicine and International Health, Charite University Medicine, Berlin, Germany
    Malar J 9:244. 2010
    ..Potentially, however, this intervention may compromise the acquisition of immunity, including the tolerance towards multiple infections with Plasmodium falciparum...
  7. pmc Efficacy of amodiaquine in the treatment of uncomplicated falciparum malaria in young children of rural north-western Burkina Faso
    Germain Mandi
    Centre de Recherche en Santé de Nouna, Nouna, Burkina Faso
    Malar J 7:58. 2008
    ..Amodiaquine is a common partner drug in different malaria combination therapies used or investigated in sub-Saharan Africa, but data on its efficacy as a single drug are scarce...
  8. pmc Allelic dimorphism of the erythrocyte binding antigen-175 (eba-175) gene of Plasmodium falciparum and severe malaria: Significant association of the C-segment with fatal outcome in Ghanaian children
    Jakob P Cramer
    Berlin Institute of Tropical Medicine, Berlin, Germany
    Malar J 3:11. 2004
    ..Possible associations of the dimorphism with severe malaria have been analysed in a case-control study in northern Ghana...
  9. pmc Decline of placental malaria in southern Ghana after the implementation of intermittent preventive treatment in pregnancy
    Lena Hommerich
    Institute of Tropical Medicine and International Health, Charite University Medicine, Berlin, Germany
    Malar J 6:144. 2007
    ..Intermittent preventive treatment in pregnancy with sulphadoxine-pyrimethamine (IPTp-SP) has been adopted as policy by many countries in sub-Saharan Africa. However, data on the post-implementation effectiveness of this measure are scarce...
  10. pmc Malaria transmission in non-endemic areas: case report, review of the literature and implications for public health management
    Thomas Zoller
    Medizinische Klinik mit Schwerpunkt Infektiologie und Pneumologie, Charite Universitatsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
    Malar J 8:71. 2009
    ..Malaria acquired in non-endemic areas remains an unlikely, but possible event for which awareness needs to be maintained...
  11. pmc Malarone treatment failure not associated with previously described mutations in the cytochrome b gene
    Ole Wichmann
    Institute of Tropical Medicine, Charite, Humboldt University, Berlin, Germany
    Malar J 3:14. 2004
    ..These findings illustrate the spread of atovaquone-proguanil-resistance in Africa and question the usefulness of codon 268 as the only target for the surveillance of its emergence...
  12. pmc High prevalence of drug-resistance mutations in Plasmodium falciparum and Plasmodium vivax in southern Ethiopia
    Mirjam Schunk
    Department of Infectious Diseases and Tropical Medicine, University of Munich, Leopoldstrasse 5, 80802 Munich, Germany
    Malar J 5:54. 2006
    ..In Ethiopia, malaria is caused by both Plasmodium falciparum and Plasmodium vivax. Drug resistance of P. falciparum to sulfadoxine-pyrimethamine (SP) and chloroquine (CQ) is frequent and intense in some areas...
  13. pmc Low frequency of the TIRAP S180L polymorphism in Africa, and its potential role in malaria, sepsis, and leprosy
    Lutz Hamann
    Institute of Medical Microbiology and Hygiene, Charite University Medical Center Berlin, Germany
    BMC Med Genet 10:65. 2009
    ....
  14. pmc Acute childhood diarrhoea in northern Ghana: epidemiological, clinical and microbiological characteristics
    Klaus Reither
    Institute of Tropical Medicine and International Health, Charite University Medicine Berlin, Berlin, Germany
    BMC Infect Dis 7:104. 2007
    ..Acute diarrhoea is a major cause of childhood morbidity and mortality in sub-Saharan Africa. Its microbiological causes and clinico-epidemiological aspects were examined during the dry season 2005/6 in Tamale, urban northern Ghana...
  15. ncbi request reprint Plasmodium falciparum dhfr but not dhps mutations associated with sulphadoxine-pyrimethamine treatment failure and gametocyte carriage in northern Ghana
    Frank P Mockenhaupt
    Institute of Tropical Medicine, Charite University Medicine Berlin, Berlin, Germany
    Trop Med Int Health 10:901-8. 2005
    ..The lack of association between dhps alleles and SP treatment outcome suggests a minor role of these molecular markers in this region at present...
  16. pmc Concurrence of Plasmodium falciparum dhfr and crt mutations in northern Ghana
    Frank P Mockenhaupt
    Institute of Tropical Medicine, Charite University Medicine Berlin, Spandauer Damm 130, 14050 Berlin, Germany
    Malar J 4:42. 2005
    ..Both chloroquine (CQ) and sulfadoxine-pyrimethamine (SP) are failing drugs in much of sub-Saharan Africa. Previous findings suggest an association between resistance to CQ and to SP in vivo, in vitro, and on the molecular level...
  17. ncbi request reprint Chloroquine-treatment failure in northern Ghana: roles of pfcrt T76 and pfmdr1 Y86
    F P Mockenhaupt
    Institute of Tropical Medicine, Charite University Medicine Berlin, Spandauer Damm 130, 14050 Berlin, Germany
    Ann Trop Med Parasitol 99:723-32. 2005
    ..In the current transition phase to alternative first-line treatment for P. falciparum malaria, it should be possible to provide estimates of the level of CQ resistance by monitoring the prevalences of these mutations...
  18. ncbi request reprint Evidence for a reduced effect of chloroquine against Plasmodium falciparum in alpha-thalassaemic children
    F P Mockenhaupt
    Institute of Tropical Medicine and Medical Faculty Charité, Humboldt University Berlin, Germany
    Trop Med Int Health 6:102-7. 2001
    ..Moreover, alpha+-thalassaemia may contribute to the expansion of CQ resistance...
  19. ncbi request reprint Common polymorphisms of toll-like receptors 4 and 9 are associated with the clinical manifestation of malaria during pregnancy
    Frank P Mockenhaupt
    Institute of Tropical Medicine and International Health, Berlin, Germany
    J Infect Dis 194:184-8. 2006
    ..These findings suggest that TLR4 and TLR9 play a role in the manifestation of malaria during pregnancy...
  20. pmc Markers of sulfadoxine-pyrimethamine-resistant Plasmodium falciparum in placenta and circulation of pregnant women
    Frank P Mockenhaupt
    Institute of Tropical Medicine and International Health, Spandauer Damm 130, 14050 Berlin, Germany
    Antimicrob Agents Chemother 51:332-4. 2007
    ..Sulfadoxine-pyrimethamine resistance typing in peripheral blood is reasonably representative of P. falciparum infecting pregnant women...
  21. pmc Detection and clinical manifestation of placental malaria in southern Ghana
    Frank P Mockenhaupt
    Institute of Tropical Medicine and International Health, Charite University Medicine, Berlin, Germany
    Malar J 5:119. 2006
    ..Plasmodium falciparum can be detected by microscopy, histidine-rich-protein-2 (HRP2) capture test or PCR but the respective clinical relevance of the thereby diagnosed infections in pregnant women is not well established...
  22. pmc Intermittent preventive treatment in infants as a means of malaria control: a randomized, double-blind, placebo-controlled trial in northern Ghana
    Frank P Mockenhaupt
    Institute of Tropical Medicine and International Health, Charite University Medicine Berlin, Berlin, Germany
    Antimicrob Agents Chemother 51:3273-81. 2007
    ..Although this simple intervention offers one of the few available malaria-preventive measures for regions where malaria is endemic, the observed rebound of severe malaria advises caution and requires further investigation...
  23. doi request reprint Rapid increase in the prevalence of sulfadoxine-pyrimethamine resistance among Plasmodium falciparum isolated from pregnant women in Ghana
    Frank P Mockenhaupt
    Institute of Topical Medicine and International Health, Charite University Medicine Berlin, Berlin, Germany
    J Infect Dis 198:1545-9. 2008
    ..Nevertheless, IPTp-SP may be outdated by drug resistance before it is fully implemented...
  24. ncbi request reprint A randomized, placebo-controlled, double-blind trial on sulfadoxine-pyrimethamine alone or combined with artesunate or amodiaquine in uncomplicated malaria
    Frank P Mockenhaupt
    Institute of Tropical Medicine, Charite, Humboldt University, Berlin, Germany
    Trop Med Int Health 10:512-20. 2005
    ....
  25. ncbi request reprint Hemoglobin C and resistance to severe malaria in Ghanaian children
    Frank P Mockenhaupt
    Institute of Tropical Medicine, Medical Faculty Charité, Humboldt University, Berlin, Germany
    J Infect Dis 190:1006-9. 2004
    ..These data support the notion that natural selection of HbC occurs because of the relative resistance it confers against severe malaria but argue against the notion that HbC offers resistance to infection...
  26. pmc Diagnosis of placental malaria
    Frank P Mockenhaupt
    Institute of Tropical Medicine, Charite, Humboldt University, Berlin, Germany
    J Clin Microbiol 40:306-8. 2002
    ..In addition to the gross underestimation of placental malaria by peripheral blood film microscopy, submicroscopic infections were found to be a risk factor for maternal anemia...
  27. ncbi request reprint Anaemia in pregnant Ghanaian women: importance of malaria, iron deficiency, and haemoglobinopathies
    F P Mockenhaupt
    Institut fur Tropenmedizin, Medizinische Fakultät Charité, Humboldt Universitat zu Berlin, Germany
    Trans R Soc Trop Med Hyg 94:477-83. 2000
    ..Haemoglobinopathies are common but, except for homozygous alpha(+)-thalassaemia, do not substantially contribute to anaemia in pregnancy. alpha(+)-Thalassaemia ameliorates malarial anaemia in pregnant women...
  28. ncbi request reprint Reduced prevalence of Plasmodium falciparum infection and of concomitant anaemia in pregnant women with heterozygous G6PD deficiency
    Frank P Mockenhaupt
    Institut für Tropenmedizin Berlin, Charite, Humboldt Universitat zu Berlin, Germany
    Trop Med Int Health 8:118-24. 2003
    ..This advantage, even if confined to multigravid women, may contribute to the selection of G6PD variants in malaria-endemic regions...
  29. ncbi request reprint Plasmodium falciparum multiplicity correlates with anaemia in symptomatic malaria
    Frank P Mockenhaupt
    Institut fur Tropenmedizin, Medizinische Fakultät Charité, Humboldt Universitat zu Berlin, Germany
    Trop Med Int Health 8:857-9. 2003
    ..High MOI not only reflects premunition but may also contribute to anaemia in symptomatic malaria...
  30. pmc Concentrations of chloroquine and malaria parasites in blood in Nigerian children
    F P Mockenhaupt
    Institute of Tropical Medicine and Medical Faculty Charité, Humboldt University, Berlin, Germany
    Antimicrob Agents Chemother 44:835-9. 2000
    ..Subtherapeutic drug levels are likely to further promote CQ resistance and may impair the development and maintenance of premunition in areas where malaria is endemic...
  31. ncbi request reprint Submicroscopic Plasmodium falciparum infections in pregnancy in Ghana
    F P Mockenhaupt
    Institute of Tropical Medicine, Medical Faculty Charité, Humboldt University Berlin, Germany
    Trop Med Int Health 5:167-73. 2000
    ..Submicroscopic P. falciparum infections are frequent and may contribute to mild anaemia and inflammation in seemingly aparasitaemic pregnant women...
  32. ncbi request reprint Limited influence of haemoglobin variants on Plasmodium falciparum msp1 and msp2 alleles in symptomatic malaria
    Frank P Mockenhaupt
    Institut fuer Tropenmedizin, Charite, Humboldt Universitaet, Spandauer Damm 130, 14050 Berlin, Germany
    Trans R Soc Trop Med Hyg 98:302-10. 2004
    ..In symptomatic children, the effect of Hb variants on parasite multiplicity and diversity appears to be limited. This may reflect an actual lack of influence or indicate abrogation in symptomatic malaria...
  33. ncbi request reprint Plasmodium falciparum pfcrt and pfmdr1 polymorphisms are associated with the pfdhfr N108 pyrimethamine-resistance mutation in isolates from Ghana
    F P Mockenhaupt
    Institut fur Tropenmedizin, Medizinische Fakultät Charité, Humboldt Universitat zu Berlin, Germany
    Trop Med Int Health 6:749-55. 2001
    ..Alternatively, it may reflect selection of resistance in persisting infections due to no longer detectable drug pressure...
  34. ncbi request reprint Alpha(+)-thalassemia protects African children from severe malaria
    Frank P Mockenhaupt
    Institute of Tropical Medicine, Charite, Humboldt University, Berlin, Germany
    Blood 104:2003-6. 2004
    ..52; 95% CI, 0.34-0.78) and to wane with age. No protective effect was discernible for homozygous children. Our findings provide evidence for natural selection of alpha(+)-thalassemia in Africa due to protection from severe malaria...
  35. ncbi request reprint Manifestation and outcome of severe malaria in children in northern Ghana
    Frank P Mockenhaupt
    Institute of Tropical Medicine, Charite, Humboldt University, Berlin, Germany
    Am J Trop Med Hyg 71:167-72. 2004
    ..The current WHO criteria serve well in identifying life-threatening disease, but also include rather mild cases that may complicate the allocation of immediate care in settings with limited resources...
  36. ncbi request reprint The contribution of alpha+-thalassaemia to anaemia in a Nigerian population exposed to intense malaria transmission
    F P Mockenhaupt
    Institute for Tropical Medicine and Medical Faculty Charité, Humboldt University, Berlin, Germany
    Trop Med Int Health 4:302-7. 1999
    ..72, 95% confidence interval: 2.85-20.90, P = 0.0001). The findings show that alpha+-thalassaemia contributes essentially to mild anaemia, microcytosis, and hypochromia in Nigeria...
  37. ncbi request reprint Serum transferrin receptor levels are increased in asymptomatic and mild Plasmodium falciparum-infection
    F P Mockenhaupt
    Institut fur Tropenmedizin, Spandauer Damm 130, 14050 Berlin, Germany
    Haematologica 84:869-73. 1999
    ..We have examined potential associations of asymptomatic and mild Plasmodium falciparum-infections and of several erythrocyte variants with sTfR values in South West Nigeria...
  38. ncbi request reprint Plasmodium falciparum infection: influence on hemoglobin levels in alpha-thalassemia and microcytosis
    F P Mockenhaupt
    Institute for Tropical Medicine and Medical Faculty Charité, Humboldt University, 14050 Berlin, Germany
    J Infect Dis 180:925-8. 1999
    ..falciparum infection was examined. Microcytosis was significantly associated with protection from hemoglobin decrease due to P. falciparum. Moreover, the rate of infection was lower in microcytic than in normocytic anemia...
  39. ncbi request reprint Impact of subpatent multi-species and multi-clonal plasmodial infections on anaemia in children from Nigeria
    J May
    Institut für Tropenmedizin und Medizinische Fakultät Charité, Humboldt Universitat zu Berlin, Berlin, Germany
    Trans R Soc Trop Med Hyg 94:399-403. 2000
    ..Hb levels and RBC counts were further diminished by additional infections with P. malariae and/or P. ovale. However, the effect of multi-species infections on haematological parameters exceeded that of multi-clonal infections...
  40. ncbi request reprint Efficacy of chloroquine in the treatment of uncomplicated, Plasmodium falciparum malaria in northern Ghana
    S Ehrhardt
    Institut fü Tropenmedizin Berlin, Charite, Humboldt Universitat zu Berlin, Spandauer Damm 130, 14050, Germany
    Ann Trop Med Parasitol 96:239-47. 2002
    ....
  41. doi request reprint Selection of pfmdr1 and pfcrt alleles in amodiaquine treatment failure in north-western Burkina Faso
    Ina Danquah
    Institute of Tropical Medicine and International Health, Charité University Medical School Berlin, Spandauer Damm 130, 14050 Berlin, Germany
    Acta Trop 114:63-6. 2010
    ..The weak association of pfmdr1/pfcrt alleles with amodiaquine treatment outcome suggests further factors to be involved in the unsatisfactory low efficacy of the drug and limits the usefulness of these markers in this area...
  42. ncbi request reprint Red cell glucose-6-phosphate dehydrogenase status and pyruvate kinase activity in a Nigerian population
    J May
    Institute for Tropical Medicine, Medical Faculty Charité, Humboldt University Berlin, Berlin, Germany
    Trop Med Int Health 5:119-23. 2000
    ..As a consequence, the reduced life span of red cells leads to an impaired diagnosis of G6PD heterozygosity when applying routine biochemical methods...
  43. ncbi request reprint Chloroquine blood concentrations and molecular markers of chloroquine-resistant Plasmodium falciparum in febrile children in northern Ghana
    Stephan Ehrhardt
    Institut für Tropenmedizin Berlin, Charite, Humboldt Universitat zu Berlin, Spandauer Damm 130, 14050 Berlin, Germany
    Trans R Soc Trop Med Hyg 97:697-701. 2003
    ..falciparum are frequent. As CQ selects resistant P. falciparum genotypes, CQ should be omitted as a first-line drug even in primary health care facilities when self-treatment with CQ is common...
  44. ncbi request reprint Multiplicity of Plasmodium falciparum infection in pregnancy
    S Beck
    Institute of Tropical Medicine, , Humboldt University, Berlin, Germany
    Am J Trop Med Hyg 65:631-6. 2001
    ..In pregnant women, the multiplicity of infection may be an important factor for the acquisition and maintenance of immunity against malaria...
  45. doi request reprint pfmdr1 mutations in imported African Plasmodium falciparum isolates
    Anja K Dippmann
    Institute of Tropical Medicine and International Health, Charite University Medicine Berlin, Spandauer Damm 130, 14050 Berlin, Germany
    Trans R Soc Trop Med Hyg 102:1148-50. 2008
    ..8%) (P=0.03). pfmdr1 184F showed an opposite pattern. pfmdr1 alleles reveal significant differences between West and East Africa, supporting the current implementation of first-line antimalarials...
  46. ncbi request reprint High residual chloroquine blood levels in African children with severe malaria seeking healthcare
    Ole Wichmann
    Institute of Tropical Medicine and International Health, Charite University Medicine, Berlin, Germany
    Trans R Soc Trop Med Hyg 101:637-42. 2007
    ..In areas of intense chloroquine resistance and frequent pre-treatment, additional administration of chloroquine at hospital admission is not only ineffective but may even further endanger patients...
  47. ncbi request reprint Renal dysfunction in children with uncomplicated, Plasmodium falciparum malaria in Tamale, Ghana
    G D Burchard
    Institut für Tropenmedizin Berlin, Charite, Humboldt Universitat Berlin, Spandauer Damm 130, 14050 Berlin, Germany
    Ann Trop Med Parasitol 97:345-50. 2003
    ..As most (85%) of the children had glomerular as well as tubular patterns of proteinuria, it appears that both glomerulonephritis and damage to tubular cells often occur in P. falciparum malaria...
  48. pmc Reduced efficacy of intermittent preventive treatment of malaria in malnourished children
    Ina Danquah
    Institute of Tropical Medicine and International Health, Charite University Medicine, Berlin, Germany
    Antimicrob Agents Chemother 53:1753-9. 2009
    ..IPTi might exhibit reduced efficacy in regions of abundant malnutrition. Concomitant nutrition programs may be needed in these places to achieve the desired impact...
  49. doi request reprint Mannose-binding lectin variant associated with severe malaria in young African children
    Ville Holmberg
    Institute of Tropical Medicine and International Health, Charite University Medicine Berlin, Spandauer Damm 130, 14050 Berlin, Germany
    Microbes Infect 10:342-8. 2008
    ..falciparum infection and manifestation of severe malaria, particularly in young children in whom specific immune responses are weak or absent...
  50. pmc Toll-like receptor (TLR) polymorphisms in African children: Common TLR-4 variants predispose to severe malaria
    Frank P Mockenhaupt
    Institute of Tropical Medicine Berlin, Charite Universitatsmedizin Berlin, Spandauer Damm 130, 14050 Berlin, Germany
    Proc Natl Acad Sci U S A 103:177-82. 2006
    ..5- and 2.6-fold increased risks of severe malaria, respectively. These findings suggest TLR4-mediated responses to malaria in vivo and TLR-4 polymorphisms to be associated with disease manifestation...
  51. ncbi request reprint Toll-like receptor (TLR) polymorphisms in African children: common TLR-4 variants predispose to severe malaria
    F P Mockenhaupt
    Institute of Tropical Medicine Berlin, Charite Universitatsmedizin Berlin, Spandauer Damm 130, 14050 Berlin, Germany
    J Commun Dis 38:230-45. 2006
    ..These findings suggest TLR4-mediated responses to malaria in vivo and TLR-4 polymorphisms to be associated with disease manifestation. However some gray areas also suggest the scope for further improvements...
  52. ncbi request reprint Short communication: high prevalence of the cytochrome P450 2C8*2 mutation in Northern Ghana
    Susanne Röwer
    Institute of Tropical Medicine, Charite University Medicine Berlin, Berlin, Germany
    Trop Med Int Health 10:1271-3. 2005
    ..We did not detect CYP2C8*3 and CYP2C8*4, but CYP2C8*2 showed an allele frequency of 0.1675. AQ metabolism in patients with CYP2C8*2 may be impaired, and with an increase of AQ based treatment the risk of severe adverse events may mount...
  53. ncbi request reprint Short communication: Prevalence of mutations associated with resistance to atovaquone and to the antifolate effect of proguanil in Plasmodium falciparum isolates from northern Ghana
    Marion Muehlen
    Institute of Tropical Medicine, Charite, Humboldt University, Berlin, Germany
    Trop Med Int Health 9:361-3. 2004
    ....
  54. doi request reprint The toll-like receptor 1 variant S248N influences placental malaria
    Lutz Hamann
    Institute for Microbiology and Hygiene, Charite University Medical Center, Dorotheenstrasse 96, 10117 Berlin, Germany
    Infect Genet Evol 10:785-9. 2010
    ..These data support that TLR-1 is involved in the recognition of P. falciparum and indicate its role in susceptibility to and manifestation of malaria in pregnancy...
  55. ncbi request reprint iNOS promoter variants and severe malaria in Ghanaian children
    Jakob P Cramer
    Institute of Tropical Medicine, Charite, Humboldt University, Berlin, Germany
    Trop Med Int Health 9:1074-80. 2004
    ..These findings suggest that iNOS promoter haplotypes rather than single nucleotide polymorphisms are associated with malaria in Ghanaian children...
  56. doi request reprint Molecular characterization of enteric viral agents from children in northern region of Ghana
    Paula Andreia Silva
    Robert Koch Institute, Berlin, Germany
    J Med Virol 80:1790-8. 2008
    ..The available rotavirus vaccines cover the predominant G1P[8] type and would reduce substantially disease burden in that area...
  57. doi request reprint Influence of haemoglobins S and C on predominantly asymptomatic Plasmodium infections in northern Ghana
    Ina Danquah
    Charite University Medicine Berlin, Spandauer Damm 130, 14050 Berlin, Germany
    Trans R Soc Trop Med Hyg 104:713-9. 2010
    ..Homozygous HbC, in contrast, confers an increased risk of P. malariae infection which conceivably may modulate falciparum malaria...
  58. ncbi request reprint Age-dependent effect of plasma nitric oxide on parasite density in Ghanaian children with severe malaria
    Jakob P Cramer
    Institute of Tropical Medicine Berlin, Charite University Medicine Berlin, Germany
    Trop Med Int Health 10:672-80. 2005
    ..This finding may have importance for the understanding of associations between iNOS variants and severe malaria in regions of differing disease manifestation...
  59. ncbi request reprint Limited influence of haptoglobin genotypes on severe malaria in Ghanaian children
    Ulrich Bienzle
    Institute of Tropical Medicine, Charite University Medicine Berlin, Berlin, Germany
    Trop Med Int Health 10:668-71. 2005
    ..6; P = 0.04). These results indicate that Hp polymorhisms may have a rather limited influence on the development of severe malaria...
  60. pmc Field evaluation of a rota- and adenovirus immunochromatographic assay using stool samples from children with acute diarrhea in Ghana
    Thomas Weitzel
    Institute of Tropical Medicine and International Health, Charite, University Medicine Berlin, Spandauer Damm 130, D 14050 Berlin, Germany
    J Clin Microbiol 45:2695-7. 2007
    ..Compared to PCR results, sensitivities and specificities were 75% and 95% for rotavirus and 22% and 84% for adenovirus. In resource-poor settings, ICTs may help to overcome difficulties in the diagnosis of rotavirus infection...
  61. ncbi request reprint In vitro antiplasmodial activity of Central American medicinal plants
    K Jenett-Siems
    Institut für Pharmazie Pharmazeutische Biologie, Freie Universitat, Berlin, Germany
    Trop Med Int Health 4:611-5. 1999
    ..0 microg/ml and 21.9 microg/ml; however, moderate cytotoxicity of active extracts was observed. Bioactivity-guided fractionation of Piper hispidum yielded 2',4, 6'-trihydroxy-4'-methoxydihydrochalcone (asebogenin) as an active compound...
  62. doi request reprint Alpha(+)-thalassaemia and malarial anaemia
    Ina Danquah
    Institute of Tropical Medicine and International Health, Charite University Medicine Berlin, Spandauer Damm 130, 14050 Berlin, Germany
    Trends Parasitol 24:479-81. 2008
    ..This mechanism might add to further alpha(+)-thalassaemic attributes that are involved in the attenuation of anaemia caused by both acute and chronic Plasmodium infections...
  63. doi request reprint Immunization of liver and renal transplant recipients: a seroepidemiological and sociodemographic survey
    C Chesi
    Institute of Tropical Medicine and International Health, Charite University Medicine, Berlin, Germany
    Transpl Infect Dis 11:507-12. 2009
    ..3%) and RTX-R (86.8%), and considerably lower for diphtheria, hepatitis A, and influenza. Immunization rates are too low in SOT recipients. Improvement will depend on a more active role of health care providers...
  64. doi request reprint High rate of resistance to locally used antibiotics among enteric bacteria from children in Northern Ghana
    Andrea Djie-Maletz
    Institute of Microbiology and Hygiene, Charite University Medicine Berlin, Berlin, Germany
    J Antimicrob Chemother 61:1315-8. 2008
    ....
  65. ncbi request reprint Field-based evidence for linkage of mutations associated with chloroquine (pfcrt/pfmdr1) and sulfadoxine-pyrimethamine (pfdhfr/pfdhps) resistance and for the fitness cost of multiple mutations in P. falciparum
    Maha E Osman
    Malaria Research Centre MalRC, Department of Biochemistry, Faculty of Medicine, University of Khartoum, PO Box 102, Khartoum, Sudan
    Infect Genet Evol 7:52-9. 2007
    ..048). However, the significantly higher gametocyte carriage rate among isolates with resistance mutations (P=0.001) is possibly an evolutionary mechanism for survival of mutant parasites...
  66. ncbi request reprint Marked differences in the prevalence of chloroquine resistance between urban and rural communities in Burkina Faso
    Peter E Meissner
    Department of Tropical Hygiene and Public Health, Ruprecht Karls University, Heidelberg, Germany
    Acta Trop 105:81-6. 2008
    ..Chloroquine (CQ) resistance has reached high levels in Africa in recent years. Little is known about variations of resistance between urban and rural areas...
  67. doi request reprint Alpha+ -thalassemia protects against anemia associated with asymptomatic malaria: evidence from community-based surveys in Tanzania and Kenya
    Jacobien Veenemans
    Cell Biology and Immunology Group, Wageningen University, Wageningen, The Netherlands
    J Infect Dis 198:401-8. 2008
    ..We assessed to what extent alpha(+)-thalassemia influences the association between mild, asymptomatic Plasmodium falciparum infection and hemoglobin concentration...
  68. pmc Large-scale surveillance of Plasmodium falciparum crt(K76T) in northern Ghana
    Stephan Ehrhardt
    Bernhard Nocht Institute for Tropical Medicine, Bernhard Nocht Strasse 74, 20359 Hamburg, Germany
    Antimicrob Agents Chemother 51:3407-9. 2007
    ..Widespread chloroquine resistance challenges the regional life span of amodiaquine as a partner drug in artemisinin combination therapy...
  69. ncbi request reprint Malaria, anemia, and malnutrition in african children--defining intervention priorities
    Stephan Ehrhardt
    Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany
    J Infect Dis 194:108-14. 2006
    ..Malaria, anemia, and malnutrition contribute substantially to childhood morbidity in sub-Saharan Africa, but their respective roles and interactions in conferring disease are complex. We aimed to investigate these interactions...
  70. ncbi request reprint Diagnosis of red cell G6PD deficiency in rural Burkina Faso: comparison of a rapid fluorescent enzyme test on filter paper with polymerase chain reaction based genotyping
    Peter E Meissner
    Department of Tropical Hygiene and Public Health, Ruprecht Karls University, Heidelberg, Germany
    Br J Haematol 131:395-9. 2005
    ..2% (95.8-99.6%) and the specificity was 97.1% (94.2-99.2%). In conclusion, the NFP assay is a reliable and inexpensive method for large-scale G6PD deficiency screening in rural West Africa...
  71. pmc Safety and efficacy of methylene blue combined with artesunate or amodiaquine for uncomplicated falciparum malaria: a randomized controlled trial from Burkina Faso
    Augustin Zoungrana
    Centre de Recherche en Santé de Nouna, Nouna, Burkina Faso
    PLoS ONE 3:e1630. 2008
    ..The objective of this study was to assess the safety and efficacy of two MB-based malaria combination therapies, MB-artesunate (AS) and MB-amodiaquine (AQ), compared to the local standard of care, AS-AQ, in Burkina Faso...
  72. ncbi request reprint High levels of circulating cardiac proteins indicate cardiac impairment in African children with severe Plasmodium falciparum malaria
    Stephan Ehrhardt
    Bernhard Nocht Institute for Tropical Medicine, Bernhard Nocht Str 74, 20359 Hamburg, Germany
    Microbes Infect 7:1204-10. 2005
    ..These deleterious metabolic conditions contribute to myocardial affection which was evident but not predictive per se of fatal outcome...