Susanne Lau

Summary

Affiliation: Humboldt University
Country: Germany

Publications

  1. pmc Interactions between genes and environmental factors in asthma and atopy: new developments
    Claudia Sengler
    Department of Pediatric Pneumology and Immunology, Charite, Humboldt University Berlin, Berlin, Germany
    Respir Res 3:7. 2002
  2. ncbi request reprint Worms, asthma, and the hygiene hypothesis
    Susanne Lau
    Department of Paediatric Pneumology and Immunology, Charité University Medical Centre, Berlin D 13353, Germany
    Lancet 367:1556-8. 2006
  3. ncbi request reprint Perennial allergen sensitisation early in life and chronic asthma in children: a birth cohort study
    Sabina Illi
    Department of Pediatric Pneumology and Immunology, Charite Universitatsmedizin Berlin, Germany
    Lancet 368:763-70. 2006
  4. ncbi request reprint Filaggrin loss-of-function mutations predispose to phenotypes involved in the atopic march
    Ingo Marenholz
    Pediatric Pneumology and Immunology, Charite University Medicine, Berlin, Germany
    J Allergy Clin Immunol 118:866-71. 2006
  5. doi request reprint Bacterial lysates in food allergy prevention
    Susanne Lau
    Department of Pediatric Pneumology and Immunology, Charité Medical University, Berlin, Germany
    Curr Opin Allergy Clin Immunol 13:293-5. 2013
  6. pmc Research needs in allergy: an EAACI position paper, in collaboration with EFA
    Nikolaos G Papadopoulos
    Allergy Department, 2nd Pediatric Clinic, University of Athens, Athens, Greece
    Clin Transl Allergy 2:21. 2012
  7. ncbi request reprint What is new in the prevention of atopy and asthma?
    Susanne Lau
    Department of Pediatric Pneumology and Immunology, Charite Campus Virchow, Charité Medical University, Berlin, Germany
    Curr Opin Allergy Clin Immunol 13:181-6. 2013
  8. doi request reprint Oral application of bacterial lysate in infancy decreases the risk of atopic dermatitis in children with 1 atopic parent in a randomized, placebo-controlled trial
    Susanne Lau
    Department of Pediatric Pneumology and Immunology, Charité Medical University Berlin, Berlin, Germany
    J Allergy Clin Immunol 129:1040-7. 2012
  9. doi request reprint Use of Phadiatop Infant in diagnosis of specific sensitization in young children with wheeze or eczema
    Susanne Lau
    Charité Medical University, Department of Pediatric Pneumology and Immunology, Berlin, Germany
    Pediatr Allergy Immunol 19:337-41. 2008
  10. ncbi request reprint Transient early wheeze is not associated with impaired lung function in 7-yr-old children
    S Lau
    Dept of Paediatric Pneumology and Immunology, Charite, Humboldt University, Berlin, Germany
    Eur Respir J 21:834-41. 2003

Collaborators

Detail Information

Publications42

  1. pmc Interactions between genes and environmental factors in asthma and atopy: new developments
    Claudia Sengler
    Department of Pediatric Pneumology and Immunology, Charite, Humboldt University Berlin, Berlin, Germany
    Respir Res 3:7. 2002
    ....
  2. ncbi request reprint Worms, asthma, and the hygiene hypothesis
    Susanne Lau
    Department of Paediatric Pneumology and Immunology, Charité University Medical Centre, Berlin D 13353, Germany
    Lancet 367:1556-8. 2006
  3. ncbi request reprint Perennial allergen sensitisation early in life and chronic asthma in children: a birth cohort study
    Sabina Illi
    Department of Pediatric Pneumology and Immunology, Charite Universitatsmedizin Berlin, Germany
    Lancet 368:763-70. 2006
    ..Unknown factors between birth and school age determine the progressive loss of pulmonary function in children with persistent asthma. We investigated the role of allergic sensitisation and allergen exposure early in life...
  4. ncbi request reprint Filaggrin loss-of-function mutations predispose to phenotypes involved in the atopic march
    Ingo Marenholz
    Pediatric Pneumology and Immunology, Charite University Medicine, Berlin, Germany
    J Allergy Clin Immunol 118:866-71. 2006
    ..Recently, 2 loss-of-function mutations in the gene encoding the epidermal barrier protein filaggrin were reported to be predisposing factors for eczema and concomitant asthma, suggesting a possible role in disease transition...
  5. doi request reprint Bacterial lysates in food allergy prevention
    Susanne Lau
    Department of Pediatric Pneumology and Immunology, Charité Medical University, Berlin, Germany
    Curr Opin Allergy Clin Immunol 13:293-5. 2013
    ..Although interventional trials using probiotics, prebiotics, hydrolyzed formula and bacterial lysates early in infancy were found to reduce the incidence of atopic dermatitis, no effect on food sensitization and allergy could be shown...
  6. pmc Research needs in allergy: an EAACI position paper, in collaboration with EFA
    Nikolaos G Papadopoulos
    Allergy Department, 2nd Pediatric Clinic, University of Athens, Athens, Greece
    Clin Transl Allergy 2:21. 2012
    ..Active involvement of all stakeholders, including Patient Organizations and policy makers are necessary to achieve the aims emphasized herein...
  7. ncbi request reprint What is new in the prevention of atopy and asthma?
    Susanne Lau
    Department of Pediatric Pneumology and Immunology, Charite Campus Virchow, Charité Medical University, Berlin, Germany
    Curr Opin Allergy Clin Immunol 13:181-6. 2013
    ..This review tries to present the current state of the art and resumes that until now, no really effective concept can be offered to families at risk...
  8. doi request reprint Oral application of bacterial lysate in infancy decreases the risk of atopic dermatitis in children with 1 atopic parent in a randomized, placebo-controlled trial
    Susanne Lau
    Department of Pediatric Pneumology and Immunology, Charité Medical University Berlin, Berlin, Germany
    J Allergy Clin Immunol 129:1040-7. 2012
    ..Lower prevalence of atopy was found in children with continuous exposure to livestock and thus to microbial compounds. In animal models exposure to endotoxin (LPS) decreases allergic sensitization and airway inflammation...
  9. doi request reprint Use of Phadiatop Infant in diagnosis of specific sensitization in young children with wheeze or eczema
    Susanne Lau
    Charité Medical University, Department of Pediatric Pneumology and Immunology, Berlin, Germany
    Pediatr Allergy Immunol 19:337-41. 2008
    ..The test thus provides an opportunity for early correct diagnosis and identification of subjects at risk for whom intervention may be necessary...
  10. ncbi request reprint Transient early wheeze is not associated with impaired lung function in 7-yr-old children
    S Lau
    Dept of Paediatric Pneumology and Immunology, Charite, Humboldt University, Berlin, Germany
    Eur Respir J 21:834-41. 2003
    ..Although transient early wheezers were found to have normal-to-subnormal lung function, children with asthmatic symptoms (persistent and late-onset disease) at age 7 yrs already show significant impairment of expiratory flow volumes...
  11. ncbi request reprint The development of childhood asthma: lessons from the German Multicentre Allergy Study (MAS)
    Susanne Lau
    University Children s Hospital, Department of Pneumology and Immunology Berlin, Charite Campus Virchow, Augustenburger Platz 1, 13353 Berlin, Germany
    Paediatr Respir Rev 3:265-72. 2002
    ....
  12. doi request reprint Transition from childhood to adult asthma
    Susanne Lau
    Department of Paediatric Pneumology and Immunology, Charite University Medicine, 13353 Berlin, Germany
    Lancet 372:1014-5. 2008
  13. ncbi request reprint Placebo-controlled study of the mite allergen-reducing effect of tannic acid plus benzyl benzoate on carpets in homes of children with house dust mite sensitization and asthma
    Susanne Lau
    University Children s Hospital Charite, Humboldt University, Berlin, Germany
    Pediatr Allergy Immunol 13:31-6. 2002
    ....
  14. ncbi request reprint Allergen avoidance as primary prevention: con
    Susanne Lau
    Children s Hospital Charity Campus Virchow, Augustenburger Platz 1, Berlin, Germany
    Clin Rev Allergy Immunol 28:17-23. 2005
    ..Although no clear primary prevention study is available for pets, mite allergen avoidance during infancy can achieve a reduction of specific sensitization and, in some studies, can also produce a slight effect on respiratory symptoms...
  15. ncbi request reprint MBL2 variants in relation to common childhood infections and atopy-related phenotypes in a large German birth cohort
    Sebastian Müller
    Department of Pediatric Pneumology and Immunology, Charité Universitäts medizin, Berlin, Germany
    Pediatr Allergy Immunol 18:665-70. 2007
    ..Our data suggest that MBL deficiency does not represent a pre-disposing factor for respiratory infections or atopic disorders in infants and children...
  16. doi request reprint An interaction between filaggrin mutations and early food sensitization improves the prediction of childhood asthma
    Ingo Marenholz
    Max Delbrück Centrum MDC for Molecular Medicine, Berlin, Germany
    J Allergy Clin Immunol 123:911-6. 2009
    ..Asthma prediction in early infancy is essential for the development of new preventive strategies. Loss-of-function mutations in the filaggrin gene (FLG) were identified as risk factors for eczema and associated asthma...
  17. ncbi request reprint Association study of Glutathione S-transferase P1 (GSTP1) with asthma and bronchial hyper-responsiveness in two German pediatric populations
    Renate Nickel
    Department of Pediatric Pneumonology and Immunology, Charite, Humboldt University, Berlin, Germany
    Pediatr Allergy Immunol 16:539-41. 2005
    ..We conclude from our data that polymorphisms within GSTP1 do not play a major role in the development of bronchial asthma in German children...
  18. doi request reprint ICOS-gene variants are not associated with atopic disease susceptibility in European children
    Katja C Beier
    Department of Paediatric Pneumology and Immunology, Charite Universitatsmedizin Berlin, Campus Virchow Klinikum, Berlin, Germany
    Pediatr Allergy Immunol 20:242-5. 2009
    ..Our data suggest that these ICOS variants do not play a major role in the development of atopy in European children...
  19. ncbi request reprint The natural course of atopic dermatitis from birth to age 7 years and the association with asthma
    Sabina Illi
    Department of Pediatric Pneumology and Immunology, Charite, Dr von Haunersches Kinderspital, Lindwurmastrasse 4, 80337 Munich, Germany
    J Allergy Clin Immunol 113:925-31. 2004
    ..Atopic dermatitis (AD) is considered to be one of the first manifestations in the atopic march. However, few prospective studies on AD and its association with childhood asthma exist...
  20. ncbi request reprint The eczema risk variant on chromosome 11q13 (rs7927894) in the population-based ALSPAC cohort: a novel susceptibility factor for asthma and hay fever
    Ingo Marenholz
    Pediatric Pneumology and Immunology, Charite University Medicine Berlin, 13353 Berlin, Germany
    Hum Mol Genet 20:2443-9. 2011
    ....
  21. ncbi request reprint Messages from the German Multicentre Allergy Study
    Renate Nickel
    Department for Pediatric Pneumology and Immunology, Charite, Berlin, Germany
    Pediatr Allergy Immunol 13:7-10. 2002
    ..Furthermore, candidate gene studies of atopic dermatitis and increased total serum IgE levels on chromosomes 5q, 12q and 17q in MAS-children and their parents are outlined...
  22. ncbi request reprint The development of atopic phenotypes: genetic and environmental determinants
    Ulrich Wahn
    Department of Pneumology, Charite Universitatsmedizin, Augustenburger Platz 1, DE 13353 Berlin, Germany
    Nestle Nutr Workshop Ser Pediatr Program 59:1-11; discussion 11-15. 2007
    ..Infantile diet, early exposure to environmental allergens and a variety of environmental and lifestyle factors may act as strong modulators of atopy during the first decade of life...
  23. doi request reprint History of respiratory infections in the first 12 yr among children from a birth cohort
    Christoph Gruber
    Department of Pediatric Pneumology and Immunology, Charite Universitatsmedizin Berlin, Berlin, Germany
    Pediatr Allergy Immunol 19:505-12. 2008
    ..Episodes within these reference values per se should not cause unwarranted concern or intervention because of suspected immunodeficiency...
  24. doi request reprint Can the use of HEPA cleaners in homes of asthmatic children and adolescents sensitized to cat and dog allergens decrease bronchial hyperresponsiveness and allergen contents in solid dust?
    Claudia Sulser
    Department of Pediatric Pneumology and Immunology, Charité Medical Centre, Berlin, Germany
    Int Arch Allergy Immunol 148:23-30. 2009
    ..Conflicting data have emerged regarding the potential benefit of air cleaners with respect to a reduction of indoor pet allergens and bronchial hyperresponsiveness (BHR)...
  25. pmc The role of polymorphisms in ADAM33, a disintegrin and metalloprotease 33, in childhood asthma and lung function in two German populations
    Michaela Schedel
    University Children s Hospital, Ludwig Maximilian s University Munich, Germany
    Respir Res 7:91. 2006
    ..Thus, we tried to further elucidate the role of ADAM33 polymorphisms (SNPs) in a genetic analysis of German case control and longitudinal populations...
  26. ncbi request reprint No association of histamine- N-methyltransferase polymorphism with asthma or bronchial hyperresponsiveness in two German pediatric populations
    Philipp Deindl
    Department of Pediatric Pneumology and Immunology, Charite Humboldt University, Berlin, Germany
    Pediatr Allergy Immunol 16:40-2. 2005
    ..We conclude that this SNP might not play a major role in the pathogenesis of asthma or BHR in German children...
  27. ncbi request reprint How should a birth cohort study be organised? Experience from the German MAS cohort study
    Renate Nickel
    University Children s Hospital, Department of Pneumology and Immunology, Charite Campus Virchow, Augustenburger Platz 1, 13353 Berlin, Germany
    Paediatr Respir Rev 3:169-76. 2002
    ....
  28. ncbi request reprint Transient suppression of atopy in early childhood is associated with high vaccination coverage
    Christoph Gruber
    Department of Pediatric Pneumology and Immunology, Charite Humboldt University, Berlin, Germany
    Pediatrics 111:e282-8. 2003
    ..To analyze prevalences of allergic sensitization and atopic disease in relation to vaccination coverage...
  29. ncbi request reprint Clara cell protein 16 (CC16) gene polymorphism influences the degree of airway responsiveness in asthmatic children
    Claudia Sengler
    Department of Pediatric Pneumology and Immunology, Charite Humboldt University, Berlin, Germany
    J Allergy Clin Immunol 111:515-9. 2003
    ..CC16 is expressed in the bronchial epithelium and exhibits potent anti-inflammatory properties. A single-nucleotide polymorphism (SNP) in the CC16 gene (A38G) was previously associated with asthma...
  30. doi request reprint Environmental noise and asthma in children: sex-specific differences
    Angelina Bockelbrink
    Institute for Social Medicine, Epidemiology, and Health Economics, Charite University Medical Center, Berlin, Germany
    J Asthma 45:770-3. 2008
    ..The aim of this study was to compare subjectively reported noise annoyance in 12-year-old asthmatic and non-asthmatic children with special regard to sex-specific differences...
  31. ncbi request reprint Parental hay fever reinforces IgE to pollen as pre-clinical biomarker of hay fever in childhood
    Laura Hatzler
    Department of Paediatric Pneumology and Immunology, Charité University Medical Centre, Berlin, Germany
    Pediatr Allergy Immunol 25:366-73. 2014
    ..An early IgE response to grass or birch pollen can anticipate seasonal allergic rhinitis to pollen later in life or remain clinically silent...
  32. ncbi request reprint A functional IL-6 receptor (IL6R) variant is a risk factor for persistent atopic dermatitis
    Jorge Esparza-Gordillo
    Pediatric Allergology, Experimental and Clinical Research Center, Charite Universitatsmedizin Berlin, Berlin, Germany
    J Allergy Clin Immunol 132:371-7. 2013
    ..Previous studies have revealed shared genetic determinants among different inflammatory disorders, suggesting that markers associated with immune-related traits might also play a role in AD...
  33. doi request reprint Molecular spreading and predictive value of preclinical IgE response to Phleum pratense in children with hay fever
    Laura Hatzler
    Department of Paediatric Pneumology and Immunology, Charité University Medical Centre, Berlin, Germany
    J Allergy Clin Immunol 130:894-901.e5. 2012
    ..IgE sensitization against grass pollen is a cause of seasonal allergic rhinitis...
  34. pmc Polymorphisms and haplotypes of acid mammalian chitinase are associated with bronchial asthma
    Sibylle Bierbaum
    University Children s Hospital, University of Freiburg, Germany
    Am J Respir Crit Care Med 172:1505-9. 2005
    ..It acts downstream of interleukin-13; inhibition of AMCase leads to an abrogated T-helper cell 2 inflammation, less bronchial hyperreactivity, and fewer eosinophils...
  35. pmc An Alu element-associated hypermethylation variant of the POMC gene is associated with childhood obesity
    Peter Kuehnen
    Institut für Experimentelle Pädiatrische Endokrinologie, Charite Universitatsmedizin Berlin, Berlin, Germany
    PLoS Genet 8:e1002543. 2012
    ..Exon 3 hypermethylation in the POMC locus represents the first identified DNA methylation variant that is associated with the individual risk for obesity...
  36. ncbi request reprint Associations between specific serum IgE response and 6 variants within the genes IL4, IL13, and IL4RA in German children: the German Multicenter Atopy Study
    Xin Liu
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    J Allergy Clin Immunol 113:489-95. 2004
    ..SNPs were commonly considered individually, and therefore the true effect could be masked by other genes or environmental factors...
  37. ncbi request reprint Associations between total serum IgE levels and the 6 potentially functional variants within the genes IL4, IL13, and IL4RA in German children: the German Multicenter Atopy Study
    Xin Liu
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    J Allergy Clin Immunol 112:382-8. 2003
    ....
  38. doi request reprint New visions for atopic eczema: an iPAC summary and future trends
    Fabienne Rance
    Hopital des Enfants, Toulouse, France
    Pediatr Allergy Immunol 19:17-25. 2008
    ..Recent developments and future directions on pathogenesis, diagnosis, natural course and prognosis are discussed...
  39. ncbi request reprint Does rhinitis lead to asthma?
    Paul Van Cauwenberge
    Department of Otorhinolaryngology, Ghent University, Belgium
    Rhinology 45:112-21. 2007
    ..Basic research has demonstrated numerous similarities in inflammatory and immunological mechanisms...
  40. ncbi request reprint How pre- and postnatal risk factors modify the effect of rapid weight gain in infancy and early childhood on subsequent fat mass development: results from the Multicenter Allergy Study 90
    Nadina Karaolis-Danckert
    Research Institute of Child Nutrition, Rheinische Friedrich Wilhelms Universitat Bonn, Dortmund, Germany
    Am J Clin Nutr 87:1356-64. 2008
    ..It is unclear which exposures may cause or modify the adverse effect of rapid weight gain on fat mass development in term children whose birth weight is appropriate-for-gestational age (AGA)...
  41. ncbi request reprint Pets--good or bad for individuals with atopic predisposition?
    Susanne Lau
    J Allergy Clin Immunol 112:263-4. 2003
  42. doi request reprint New visions in specific immunotherapy in children: an iPAC summary and future trends
    Susanne Halken
    HC Andersen Childrens Hospital, Odense University Hospital, Odense, Denmark
    Pediatr Allergy Immunol 19:60-70. 2008
    ..This review was initiated by iPAC (international Pediatric Allergy and Asthma Consortium) and aims to review current knowledge related to specific immunotherapy in childhood, and to identify needs for future research in this field...