U E Lang

Summary

Affiliation: Humboldt University
Country: Germany

Publications

  1. ncbi request reprint Molecular mechanisms of schizophrenia
    Undine E Lang
    Department of Psychiatry, Charite University Medicine Berlin, Campus Mitte, Berlin Germany
    Cell Physiol Biochem 20:687-702. 2007
  2. doi request reprint Immunosuppression using the mammalian target of rapamycin (mTOR) inhibitor everolimus: pilot study shows significant cognitive and affective improvement
    U E Lang
    Department of Psychiatry and Psychotherapy, Charite University Medicine Berlin, Campus Mitte, Chariteplatz 1, 10117 Berlin, Germany
    Transplant Proc 41:4285-8. 2009
  3. ncbi request reprint Acute prefrontal cortex transcranial magnetic stimulation in healthy volunteers: no effects on brain-derived neurotrophic factor (BDNF) concentrations in serum
    Undine E Lang
    Department of Psychiatry and Psychotherapy, Charite University Medicine Berlin, Campus Mitte, Chariteplatz 1, 10117 Berlin, Germany
    J Affect Disord 107:255-8. 2008
  4. doi request reprint Gender-dependent association of a functional NGF polymorphism with anxiety-related personality traits
    U E Lang
    Clinic for Psychiatry and Psychotherapy, Charité Medicine Berlin, Campus Charite Mitte, Berlin, Germany
    Pharmacopsychiatry 41:196-9. 2008
  5. ncbi request reprint Motorcortical excitability after electroconvulsive therapy in patients with major depressive disorder
    Malek Bajbouj
    Department of Psychiatry, Charite University Medicine Berlin, Campus Benjamin Franklin, Eschenallee 3, 14050 Berlin, Germany
    Suppl Clin Neurophysiol 56:433-40. 2003
  6. doi request reprint Met carriers of BDNF Val66Met genotype show increased N-acetylaspartate concentration in the anterior cingulate cortex
    Jurgen Gallinat
    Department of Psychiatry and Psychotherapy, Charite, University Medicine Berlin, Campus Mitte, Berlin, Germany
    Neuroimage 49:767-71. 2010
  7. ncbi request reprint Association between cerebral glutamate and human behaviour: the sensation seeking personality trait
    J Gallinat
    Department of Psychiatry and Psychotherapy, Charite University Medicine Berlin, Campus Mitte, University Hospital of Dresden, Germany
    Neuroimage 34:671-8. 2007
  8. ncbi request reprint Correlation between serum brain-derived neurotrophic factor level and an in vivo marker of cortical integrity
    Undine E Lang
    Department of Psychiatry and Psychotherapy, Charite University Medicine Berlin, Campus Mitte, Berlin, Germany
    Biol Psychiatry 62:530-5. 2007
  9. ncbi request reprint No association of a functional polymorphism in the serotonin transporter gene promoter and anxiety-related personality traits
    Undine E Lang
    Department of Psychiatry, Benjamin Franklin Medical School, Free University of Berlin, Germany
    Neuropsychobiology 49:182-4. 2004
  10. ncbi request reprint DTNBP1 (dysbindin) gene variants: in vivo evidence for effects on hippocampal glutamate status
    C Wirth
    Charite University Medicine Berlin, Campus Mitte, Clinic for Psychiatry and Psychotherapy, 10117 Berlin, Germany
    Curr Pharm Biotechnol 13:1513-21. 2012

Collaborators

Detail Information

Publications45

  1. ncbi request reprint Molecular mechanisms of schizophrenia
    Undine E Lang
    Department of Psychiatry, Charite University Medicine Berlin, Campus Mitte, Berlin Germany
    Cell Physiol Biochem 20:687-702. 2007
    ..In a unifying hypothesis, different cascades merge into another that ultimately lead to the development of symptoms adherent to schizophrenic disorders...
  2. doi request reprint Immunosuppression using the mammalian target of rapamycin (mTOR) inhibitor everolimus: pilot study shows significant cognitive and affective improvement
    U E Lang
    Department of Psychiatry and Psychotherapy, Charite University Medicine Berlin, Campus Mitte, Chariteplatz 1, 10117 Berlin, Germany
    Transplant Proc 41:4285-8. 2009
    ..Preclinical evidence has implicated the mTOR pathway in synaptic plasticity and fear memory consolidation and reconsolidation...
  3. ncbi request reprint Acute prefrontal cortex transcranial magnetic stimulation in healthy volunteers: no effects on brain-derived neurotrophic factor (BDNF) concentrations in serum
    Undine E Lang
    Department of Psychiatry and Psychotherapy, Charite University Medicine Berlin, Campus Mitte, Chariteplatz 1, 10117 Berlin, Germany
    J Affect Disord 107:255-8. 2008
    ..BDNF serum concentrations have been shown to be decreased in patients with major depressive disorder and can be upregulated by several antidepressive treatment strategies including repetitive TMS...
  4. doi request reprint Gender-dependent association of a functional NGF polymorphism with anxiety-related personality traits
    U E Lang
    Clinic for Psychiatry and Psychotherapy, Charité Medicine Berlin, Campus Charite Mitte, Berlin, Germany
    Pharmacopsychiatry 41:196-9. 2008
    ..Nerve growth factor (NGF) has been shown to be involved in anxiety behaviour and the expression of conditioned fear in mice...
  5. ncbi request reprint Motorcortical excitability after electroconvulsive therapy in patients with major depressive disorder
    Malek Bajbouj
    Department of Psychiatry, Charite University Medicine Berlin, Campus Benjamin Franklin, Eschenallee 3, 14050 Berlin, Germany
    Suppl Clin Neurophysiol 56:433-40. 2003
  6. doi request reprint Met carriers of BDNF Val66Met genotype show increased N-acetylaspartate concentration in the anterior cingulate cortex
    Jurgen Gallinat
    Department of Psychiatry and Psychotherapy, Charite, University Medicine Berlin, Campus Mitte, Berlin, Germany
    Neuroimage 49:767-71. 2010
    ..We hypothesize that higher NAA levels in the ACC might contribute to the protection of Met allele carriers against major psychiatric disorders as schizophrenia and bipolar disorder...
  7. ncbi request reprint Association between cerebral glutamate and human behaviour: the sensation seeking personality trait
    J Gallinat
    Department of Psychiatry and Psychotherapy, Charite University Medicine Berlin, Campus Mitte, University Hospital of Dresden, Germany
    Neuroimage 34:671-8. 2007
    ..However, the role of glutamate in related personality traits like sensation seeking has not been investigated in humans...
  8. ncbi request reprint Correlation between serum brain-derived neurotrophic factor level and an in vivo marker of cortical integrity
    Undine E Lang
    Department of Psychiatry and Psychotherapy, Charite University Medicine Berlin, Campus Mitte, Berlin, Germany
    Biol Psychiatry 62:530-5. 2007
    ..In the present study we hypothesized that serum BDNF concentration is associated with in vivo level of cerebral N-acetylaspartate (NAA), a well established marker of neuronal integrity...
  9. ncbi request reprint No association of a functional polymorphism in the serotonin transporter gene promoter and anxiety-related personality traits
    Undine E Lang
    Department of Psychiatry, Benjamin Franklin Medical School, Free University of Berlin, Germany
    Neuropsychobiology 49:182-4. 2004
    ..f. = 2) in all subjects. Given the small effect of this 5-HTT polymorphism on behaviour in previous studies, a lack of significant genotype differences in these tests could be due to considerable individual variability in these measures...
  10. ncbi request reprint DTNBP1 (dysbindin) gene variants: in vivo evidence for effects on hippocampal glutamate status
    C Wirth
    Charite University Medicine Berlin, Campus Mitte, Clinic for Psychiatry and Psychotherapy, 10117 Berlin, Germany
    Curr Pharm Biotechnol 13:1513-21. 2012
    ....
  11. doi request reprint Clozapine-induced myocarditis after long-term treatment: case presentation and clinical perspectives
    U E Lang
    Department of Psychiatry and Psychotherapy, Charité Medicine Berlin, Campus Mitte, Berlin, Germany
    J Psychopharmacol 22:576-80. 2008
    ....
  12. ncbi request reprint State of the art of the neurotrophin hypothesis in psychiatric disorders: implications and limitations
    U E Lang
    Department of Psychiatry, Campus Benjamin Franklin, Charite University Medicine, Berlin, Germany
    J Neural Transm 111:387-411. 2004
    ..In conclusion, the issue of neuroprotection and neurotrophins is recognised as an important new lead in the quest for a deeper understanding of psychiatric disorders and the mechanisms of action of psychopharmacological interventions...
  13. ncbi request reprint Effects of right unilateral electroconvulsive therapy on motor cortical excitability in depressive patients
    Malek Bajbouj
    Department of Psychiatry, Charite University Medicine Berlin, Campus Benjamin Franklin, Eschenallee 3, 14050 Berlin, Germany
    J Psychiatr Res 40:322-7. 2006
    ..We interpret this finding as further indirect evidence for changes in inhibitory circuits in the course of ECT in patients with major depression...
  14. ncbi request reprint Repetitive transcranial magnetic stimulation of the dorsolateral prefrontal cortex and cortical excitability in patients with major depressive disorder
    Malek Bajbouj
    Department of Psychiatry, Charite University Medicine Berlin, Campus Benjamin Franklin, Eschenallee 3, 14050 Berlin, Germany
    Exp Neurol 196:332-8. 2005
    ..Furthermore, measurement of motor cortical excitability may be a useful tool for investigating and monitoring inhibitory brain effects of antidepressant stimulation techniques like rTMS...
  15. ncbi request reprint Motor cortex excitability after vagus nerve stimulation in major depression
    Malek Bajbouj
    Department of Psychiatry, Charite Universitatsmedizin Berlin, Germany
    J Clin Psychopharmacol 27:156-9. 2007
    ..These results suggest that VNS is capable of changing motor cortical excitability in patients with depression...
  16. ncbi request reprint Abnormal hippocampal neurochemistry in smokers: evidence from proton magnetic resonance spectroscopy at 3 T
    Jurgen Gallinat
    Klinik fur Psychiatrie und Psychotherapie, Charite Universitatsmedizin, Campus Mitte PUK Charité SHK, Berlin, Germany
    J Clin Psychopharmacol 27:80-4. 2007
    ..In this study, proton magnetic resonance spectroscopy was used to assess the effects of chronic smoking on neuronal integrity of the hippocampus and anterior cingulate cortex (ACC)...
  17. doi request reprint Acute exercise ameliorates reduced brain-derived neurotrophic factor in patients with panic disorder
    Andreas Strohle
    Department of Psychiatry and Psychotherapy, Campus Charite Mitte, Charite Universitatsmedizin Berlin, Chariteplatz 1, 10117 Berlin, Germany
    Psychoneuroendocrinology 35:364-8. 2010
    ....
  18. ncbi request reprint Association of human hippocampal neurochemistry, serotonin transporter genetic variation, and anxiety
    Jurgen Gallinat
    Clinic for Psychiatry and Psychotherapy, Charite University Medicine, Berlin, Germany
    Neuroimage 26:123-31. 2005
    ....
  19. ncbi request reprint Motor cortical excitability in depressive patients after electroconvulsive therapy and repetitive transcranial magnetic stimulation
    Malek Bajbouj
    Department of Psychiatry, Charite University Medicine Berlin, Campus Benjamin Franklin, Berlin, Germany
    J ECT 21:243-5. 2005
    ..Furthermore, measurement of motor cortical excitability may be a useful tool for investigating and monitoring inhibitory brain effects of different antidepressant stimulation techniques...
  20. ncbi request reprint Brain-derived neurotrophic factor serum concentrations are increased in drug-naive schizophrenic patients with chronic cannabis abuse and multiple substance abuse
    Maria C Jockers-Scherübl
    Department of Psychiatry and Psychotherapy, Charite University Medicine Berlin, Campus Benjamin Franklin, Eschenallee 3, 14050 Berlin, Germany
    Neurosci Lett 371:79-83. 2004
    ..In line with this hypothesis, disease onset was 5.2 years earlier in the cannabis-consuming group (p = 0.0111)...
  21. ncbi request reprint Evidence for impaired cortical inhibition in patients with unipolar major depression
    Malek Bajbouj
    Department of Psychiatry, Charite University Medicine Berlin, Berlin, Germany
    Biol Psychiatry 59:395-400. 2006
    ..Transcranial magnetic stimulation is a useful tool for investigating central cortical inhibitory mechanisms associated with GABAergic neurotransmission in psychiatric and neurological disorders...
  22. doi request reprint COMT Val108/158Met genotype modulates human sensory gating
    Tomislav Majic
    Clinic for Psychiatry and Psychotherapy, Charite University Medicine, Campus Mitte, Berlin, Germany
    Neuroimage 55:818-24. 2011
    ..It is however unclear if COMT genotype as a predictor of prefrontal efficiency modulates sensory gating on the level of the auditory cortex, i.e. the gating of the auditory evoked P50 and N100 components...
  23. ncbi request reprint Abnormalities of inhibitory neuronal mechanisms in the motor cortex of patients with schizophrenia
    M Bajbouj
    Labor für Klinische Psychophysiologie, Department of Psychiatry, Freie Universitat Berlin, Berlin, Germany
    Pharmacopsychiatry 37:74-80. 2004
    ..PI and TI were studied to explore whether dopaminergic neurotransmission or interhemispheric transfers are altered in schizophrenia...
  24. ncbi request reprint No nerve growth factor response to treatment with memantine in adult rats
    U E Lang
    Department of Psychiatry, Campus Benjamin Franklin, Charité Medicine Berlin, Berlin, Germany
    J Neural Transm 111:181-90. 2004
    ....
  25. ncbi request reprint Nerve growth factor response to excitotoxic lesion of the cholinergic basal forebrain is slightly impaired in aged rats
    C A Gericke
    Department of Psychiatry, Free University of Berlin, Berlin, Germany
    J Neural Transm 110:627-39. 2003
    ..These results indicate that the compensatory NGF increase in the posterior cortex after partial cholinergic lesion of the basal forebrain is slightly impaired in old age...
  26. doi request reprint [Genetics of weight gain associated with antipsychotic medications]
    D J Muller
    Klinik fur Psychiatrie und Psychotherapie, Charite Universitatsmedizin Berlin, Campus Mitte, Chariteplatz 1, 10117, Berlin
    Nervenarzt 80:556-63. 2009
    ..Nonetheless the first steps towards genetic risk assessment have been performed, and its application in the near future has become likely...
  27. ncbi request reprint Association of the met66 allele of brain-derived neurotrophic factor (BDNF) with smoking
    Undine E Lang
    Department of Psychiatry and Psychotherapy, University of Dresden, Fetscherstr 74, 01307, Dresden, Germany
    Psychopharmacology (Berl) 190:433-9. 2007
    ..In this study, we addressed the question if a common BDNF missense variation (Val66Met) influences the risk for smoking behavior in otherwise healthy human volunteers...
  28. ncbi request reprint Serotonergic effects of smoking are independent from the human serotonin transporter gene promoter polymorphism: evidence from auditory cortical stimulus processing
    J Gallinat
    Clinic for Psychiatry and Psychotherapy, Charite University Medicine, Campus Mitte, Berlin, Germany
    Pharmacopsychiatry 38:158-60. 2005
    ..Moreover, smoking behavior has been associated to the 5-HTT-genotype. It was hypothesized that cigarette smoking modulates the LD and this effect was expected to interact with the 5-HTT-genotype...
  29. ncbi request reprint Brain-derived neurotrophic factor serum concentrations in depressive patients during vagus nerve stimulation and repetitive transcranial magnetic stimulation
    Undine E Lang
    Department of Psychiatry, University of Dresden, Fetscherstr 74, 01099 Dresden, Germany
    Psychopharmacology (Berl) 187:56-9. 2006
    ..Vagus nerve stimulation (VNS) and repetitive transcranial magnetic stimulation (rTMS) of the dorsolateral prefrontal cortex are brain stimulation techniques used as therapeutic interventions in major depression...
  30. doi request reprint Higher BDNF concentrations in the hippocampus and cortex of an aggressive mouse strain
    Undine E Lang
    Department of Psychiatry and Psychotherapy, Charité Medicine Berlin, Campus Mitte, Chariteplatz 1, 10119 Berlin, Germany
    Behav Brain Res 197:246-9. 2009
    ..We hypothesize, that BDNF might be involved in the behavioural and neurochemical mechanisms of aggressive behaviour...
  31. ncbi request reprint Chronic cannabis abuse raises nerve growth factor serum concentrations in drug-naive schizophrenic patients
    Maria C Jockers-Scherübl
    Department of Psychiatry and Psychotherapy, Charite University Medicine Berlin, Campus Benjamin Franklin, Berlin, Germany
    J Psychopharmacol 17:439-45. 2003
    ..These results indicate that cannabis is a possible risk factor for the development of schizophrenia. This might be reflected in the raised NGF-serum concentrations when both schizophrenia and long-term cannabis abuse prevail...
  32. ncbi request reprint Subchronic treatment with lithium increases nerve growth factor content in distinct brain regions of adult rats
    R Hellweg
    Department of Psychiatry, Free University of Berlin, Berlin, Germany
    Mol Psychiatry 7:604-8. 2002
    ..Our findings lend support to the notion that an enhancement of NGF production may be specifically involved in the mechanisms of action of antibipolar treatments...
  33. ncbi request reprint BDNF serum concentrations in healthy volunteers are associated with depression-related personality traits
    Undine E Lang
    Clinic for Psychiatry and Psychotherapy, Charité Medicine Berlin, Campus Benjamin Franklin, Germany
    Neuropsychopharmacology 29:795-8. 2004
    ..These results provide further support for the hypothesis that BDNF may be central to the development of depressive mood states...
  34. ncbi request reprint Gender-dependent association of the functional catechol-O-methyltransferase Val158Met genotype with sensation seeking personality trait
    Undine E Lang
    Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Fetscherstrasse 74, 01307 Dresden, Germany
    Neuropsychopharmacology 32:1950-5. 2007
    ....
  35. ncbi request reprint Serum neurotrophins--a study on the time course and influencing factors in a large old age sample
    Andreas A Ziegenhorn
    Department of Psychiatry, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Eschenallee 3, 14050 Berlin, Germany
    Neurobiol Aging 28:1436-45. 2007
    ..344, p<0.01), age and BDNF protein (r=-0.101, p=0.029) and BDNF and NGF serum levels (r=0.152, p=0.04). No other major influencing factors were found including gender, depression, and dementia...
  36. ncbi request reprint Emotional instability but intact spatial cognition in adenosine receptor 1 knock out mice
    Undine E Lang
    Department of Psychiatry, Free University of Berlin, Eschenallee 3, Berlin 14050, Germany
    Behav Brain Res 145:179-88. 2003
    ....
  37. ncbi request reprint Nerve growth factor serum concentrations in healthy human volunteers: physiological variance and stability
    Undine E Lang
    Department of Psychiatry, Free University of Berlin, Eschenallee 3, 14050 Berlin, Germany
    Neurosci Lett 344:13-6. 2003
    ..This stability of our repetitive measurements over 4 weeks suggests that this neurotrophin may be an intraindividually solid marker at least in human serum...
  38. ncbi request reprint Association of BDNF serum concentrations with central serotonergic activity: evidence from auditory signal processing
    Undine E Lang
    Department of Neurology, University of Tuebingen, Tuebingen, Germany
    Neuropsychopharmacology 30:1148-53. 2005
    ..185, p=0.055). Although this association needs to be replicated, the results are in line with the assumption that low serum BDNF levels reflect low central serotonergic neurotransmission as indicated by a strong LD...
  39. ncbi request reprint Association of a functional BDNF polymorphism and anxiety-related personality traits
    Undine E Lang
    Department of Neurology, University of Tuebingen, Hoppe Seyler Str 3, 72076 Tuebingen, Germany
    Psychopharmacology (Berl) 180:95-9. 2005
    ..The association to anxiety-related traits has not been investigated so far...
  40. ncbi request reprint Influence of gain of function epithelial chloride channel ClC-Kb mutation on hearing thresholds
    Andreas Frey
    Department of Physiology, University of Tubingen, Gmelinstrasse 5, D 72076 Tubingen, Germany
    Hear Res 214:68-75. 2006
    ..In conclusion, hearing thresholds are slightly lower in carriers of ClC-Kb(T481S), i.e., the gain-of-function polymorphism ClC-Kb(T481S) exerts a subtle but significant protective effect against hearing loss...
  41. ncbi request reprint Therapeutic brain stimulation and cortical excitability in depressed patients
    Malek Bajbouj
    Am J Psychiatry 162:2192-3. 2005
  42. ncbi request reprint Impact of levodopa on reduced nerve growth factor levels in patients with Parkinson disease
    Thomas Muller
    Department of Neurology, St Josef Hospital, Ruhr University Bochum, Germany
    Clin Neuropharmacol 28:238-40. 2005
    ....
  43. pmc Regulation of GluR1 abundance in murine hippocampal neurones by serum- and glucocorticoid-inducible kinase 3
    Nathalie Strutz-Seebohm
    Department of Physiology I, University of Tuebingen, 72076 Tuebingen, Germany
    J Physiol 565:381-90. 2005
    ..The present observations disclose a novel mechanism in the regulation of GluR1...
  44. ncbi request reprint Basal serum levels and reactivity of nerve growth factor and brain-derived neurotrophic factor to standardized acute exercise in multiple sclerosis and controls
    Stefan M Gold
    Department of Neurology, University Hospital Hamburg Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany
    J Neuroimmunol 138:99-105. 2003
    ..We conclude that moderate exercise can be used to induce neutrophin production in humans. This may mediate beneficial effects of physical exercise in MS reported recently...
  45. ncbi request reprint Mice with reduced brain-derived neurotrophic factor expression show decreased choline acetyltransferase activity, but regular brain monoamine levels and unaltered emotional behavior
    Sabine Chourbaji
    Central Institut of Mental Health Mannheim CIMA, University of Heidelberg, Mannheim J 5 D 68159, Germany
    Brain Res Mol Brain Res 121:28-36. 2004
    ..Thus, a chronic reduction of BDNF protein content in adult mice is not sufficient to induce neurochemical or behavioral alterations that are reminiscent of depressive symptoms in humans...