A Kupsch

Summary

Affiliation: Humboldt University
Country: Germany

Publications

  1. ncbi request reprint Monoamine oxidase-inhibition and MPTP-induced neurotoxicity in the non-human primate: comparison of rasagiline (TVP 1012) with selegiline
    A Kupsch
    Department of Neurology, Klinikum Grosshadern, Ludwig Maximilians University, and Institute of Physiology, Munchen, Federal Republic of Germany
    J Neural Transm (Vienna) 108:985-1009. 2001
  2. doi request reprint Early postoperative management of DBS in dystonia: programming, response to stimulation, adverse events, medication changes, evaluations, and troubleshooting
    Andreas Kupsch
    Division of Neurology, Charite, Campus Virchow, Berlin, Germany
    Mov Disord 26:S37-53. 2011
  3. ncbi request reprint Deep brain stimulation in dystonia
    Andreas Kupsch
    Dept of Neurology and Neurosurgery, Augustenburger Platz 1, 13353 Berlin, Germany
    J Neurol 250:I47-52. 2003
  4. ncbi request reprint Levodopa therapy with entacapone in daily clinical practice: results of a post-marketing surveillance study
    Andreas Kupsch
    Department of Neurology, Homboldt University of Berlin, Charite, Augustenburger Platz 1, 13353 Berlin, Germany
    Curr Med Res Opin 20:115-20. 2004
  5. ncbi request reprint Rasagiline. Teva Pharmaceutical
    Andreas Kupsch
    Department of Neurology, Charite Virchow, Berlin, Germany
    Curr Opin Investig Drugs 3:794-7. 2002
  6. ncbi request reprint The effects of frequency in pallidal deep brain stimulation for primary dystonia
    A Kupsch
    Dept of Neurology, Charite, Campus Virchow, Humboldt University Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
    J Neurol 250:1201-5. 2003
  7. doi request reprint Anticipatory activity in the human thalamus is predictive of reaction times
    V V Nikulin
    Department of Neurology, Charite University Medicine Berlin, Berlin, Germany
    Neuroscience 155:1275-83. 2008
  8. ncbi request reprint Modulation of motor cortex excitability by pallidal stimulation in patients with severe dystonia
    A A Kühn
    Department of Neurology, Charite, Campus Virchow Klinikum, Humboldt University Berlin, Germany
    Neurology 60:768-74. 2003
  9. ncbi request reprint 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity in non-human primates is antagonized by pretreatment with nimodipine at the nigral, but not at the striatal level
    A Kupsch
    Ludwig Maximilians University, Klinikum Grosshadern, Department of Neurology, Munchen, Germany
    Brain Res 741:185-96. 1996
  10. ncbi request reprint Imaging of dopamine transporters and D2 receptors in vascular parkinsonism: a report of four cases
    M Plotkin
    Department of Radiology, Nuclear Medicine and Radiooncology, Berlin, Germany
    J Neural Transm (Vienna) 112:1355-61. 2005

Collaborators

Detail Information

Publications96

  1. ncbi request reprint Monoamine oxidase-inhibition and MPTP-induced neurotoxicity in the non-human primate: comparison of rasagiline (TVP 1012) with selegiline
    A Kupsch
    Department of Neurology, Klinikum Grosshadern, Ludwig Maximilians University, and Institute of Physiology, Munchen, Federal Republic of Germany
    J Neural Transm (Vienna) 108:985-1009. 2001
    ..It remains to be determined, if this histological observation represents potential adverse effects of high dose treatment with monoamine oxidase inhibitors...
  2. doi request reprint Early postoperative management of DBS in dystonia: programming, response to stimulation, adverse events, medication changes, evaluations, and troubleshooting
    Andreas Kupsch
    Division of Neurology, Charite, Campus Virchow, Berlin, Germany
    Mov Disord 26:S37-53. 2011
    ..The present chapter summarizes the available data about and concentrates on practical clinical aspects of early postoperative management in deep brain stimulation-treated patients with dystonia...
  3. ncbi request reprint Deep brain stimulation in dystonia
    Andreas Kupsch
    Dept of Neurology and Neurosurgery, Augustenburger Platz 1, 13353 Berlin, Germany
    J Neurol 250:I47-52. 2003
    ..Furthermore, the optimal target for different dystonic disorders remains to be determined, although the globus pallidus internus has currently emerged as the most promising target for dystonia...
  4. ncbi request reprint Levodopa therapy with entacapone in daily clinical practice: results of a post-marketing surveillance study
    Andreas Kupsch
    Department of Neurology, Homboldt University of Berlin, Charite, Augustenburger Platz 1, 13353 Berlin, Germany
    Curr Med Res Opin 20:115-20. 2004
    ....
  5. ncbi request reprint Rasagiline. Teva Pharmaceutical
    Andreas Kupsch
    Department of Neurology, Charite Virchow, Berlin, Germany
    Curr Opin Investig Drugs 3:794-7. 2002
    ..In the same month, launch was predicted in 2004/2005 for the PD indication, and 2005/2006 for the AD indication, by analysts at Deutsche Banc Alex Brown...
  6. ncbi request reprint The effects of frequency in pallidal deep brain stimulation for primary dystonia
    A Kupsch
    Dept of Neurology, Charite, Campus Virchow, Humboldt University Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
    J Neurol 250:1201-5. 2003
    ..Compared with 130 Hz a significant further clinical improvement was observed at frequencies of 180 and 250 Hz, which contrasted with a significant deterioration at lower frequencies (5, 50 Hz) compared to 130 Hz...
  7. doi request reprint Anticipatory activity in the human thalamus is predictive of reaction times
    V V Nikulin
    Department of Neurology, Charite University Medicine Berlin, Berlin, Germany
    Neuroscience 155:1275-83. 2008
    ..In contrast, it indicates that the latencies at which we respond to environmental stimuli are not exclusively related to cortical pre-movement states but are also correlated with anticipatory thalamic activity...
  8. ncbi request reprint Modulation of motor cortex excitability by pallidal stimulation in patients with severe dystonia
    A A Kühn
    Department of Neurology, Charite, Campus Virchow Klinikum, Humboldt University Berlin, Germany
    Neurology 60:768-74. 2003
    ..To study the influence of continuous high-frequency electrical stimulation with electrodes implanted in the globus pallidus internus (GPi) on motor cortex excitability in nine patients with dystonia...
  9. ncbi request reprint 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity in non-human primates is antagonized by pretreatment with nimodipine at the nigral, but not at the striatal level
    A Kupsch
    Ludwig Maximilians University, Klinikum Grosshadern, Department of Neurology, Munchen, Germany
    Brain Res 741:185-96. 1996
    ....
  10. ncbi request reprint Imaging of dopamine transporters and D2 receptors in vascular parkinsonism: a report of four cases
    M Plotkin
    Department of Radiology, Nuclear Medicine and Radiooncology, Berlin, Germany
    J Neural Transm (Vienna) 112:1355-61. 2005
    ..The possible value of combined DAT/D2 receptor SPECT imaging should be investigated by future prospective studies...
  11. doi request reprint Automated optimization of subcortical cerebral MR imaging-atlas coregistration for improved postoperative electrode localization in deep brain stimulation
    T Schönecker
    Department of Neuroradiology, Campus Virchow, Charite University Medicine, Berlin, Germany
    AJNR Am J Neuroradiol 30:1914-21. 2009
    ....
  12. doi request reprint Long-term effects of pallidal deep brain stimulation in tardive dystonia
    D Gruber
    Department of Neurology, Charite, University Medicine Berlin, Campus Virchow, Berlin, Germany
    Neurology 73:53-8. 2009
    ..Here, we show the long-term effect of continuous bilateral GPi DBS in tardive dystonia on motor function, quality of life (QoL), and mood...
  13. ncbi request reprint [Apomorphine therapy versus deep rain stimulation. Clinical and economic aspects in patients with advanced Parkinson disease]
    W Meissner
    Neurologische Klinik und Poliklinik, , , Augustenburger Platz 1, 13353 Berlin
    Nervenarzt 72:924-7. 2001
    ..Thus, to further ensure deep-brain stimulation in parkinsonian patients it is mandatory to find a mode of reimbursement for the institutions concerned...
  14. pmc Pallidal and thalamic neurostimulation in severe tardive dystonia
    T Trottenberg
    Department of Neurology, Humboldt University, Charite Virchow, Augustenburger Platz 1, 13353 Berlin, Germany
    J Neurol Neurosurg Psychiatry 70:557-9. 2001
    ..Stimulation of the VIM did not improve the hyperkinetic movements and simultaneous stimulation of both the GPi and the VIM did not result in any additional benefit. The possible pathophysiological mechanisms are discussed...
  15. doi request reprint Quadruple deep brain stimulation in Huntington's disease, targeting pallidum and subthalamic nucleus: case report and review of the literature
    D Gruber
    Department of Neurology, Charite University Medicine Berlin, Campus Virchow Klinikum, Augustenburger Platz 1, 13353, Berlin, Germany
    J Neural Transm (Vienna) 121:1303-12. 2014
    ....
  16. pmc Functional connectivity between motor cortex and globus pallidus in human non-REM sleep
    F Salih
    Department of Neurology, Charite Universitatsmedizin Berlin, Germany
    J Physiol 587:1071-86. 2009
    ..5 Hz, possibly as a specific signature of the motor system in human non-REM sleep. This finding is pertinent to the longstanding debate about the nature of alpha-delta sleep as a physiological or pathological feature of non-REM sleep...
  17. ncbi request reprint Striatal dopaminergic metabolism is increased by deep brain stimulation of the subthalamic nucleus in 6-hydroxydopamine lesioned rats
    W Meissner
    Department of Neurology, , Humboldt-University Berlin, Augustenburger Platz 1, 13353, Berlin, Germany
    Neurosci Lett 303:165-8. 2001
    ..Our results indicate that deep brain stimulation of the subthalamic nucleus affects significantly striatal dopaminergic metabolism in 6-hydroxydopamine lesioned rats...
  18. ncbi request reprint Treatment of severe tardive dystonia with pallidal deep brain stimulation
    T Trottenberg
    Department of Neurology, Charite Campus Virchow, Humboldt University, Berlin, Germany
    Neurology 64:344-6. 2005
    ..7 SD of the motor part of the Burke-Fahn-Marsden Dystonia Rating Scale) improvement of dystonia and functional disability without adverse events...
  19. ncbi request reprint Sympathetic activation due to deep brain stimulation in the region of the STN
    A Lipp
    Department of Neurology, Medical Faculty of the Charite, Berlin, Germany
    Neurology 65:774-5. 2005
  20. ncbi request reprint Patterns of abnormal motor cortex excitability in atypical parkinsonian syndromes
    A A Kühn
    Department of Neurology, Charite, Humboldt University Berlin, 13353 Berlin, Augustenburger Platz 1, Germany
    Clin Neurophysiol 115:1786-95. 2004
    ..We hypothesised that these atypical parkinsonian syndromes (APS) will show distinctive patterns in their motor output upon transcranial magnetic stimulation (TMS) due to their different underlying anatomico-functional deficits...
  21. doi request reprint Midbrain serotonin transporters in de novo and L-DOPA-treated patients with early Parkinson's disease--a [123 I]-ADAM SPECT study
    J C Beucke
    Department of Clinical Psychology, Humboldt University Berlin, Berlin, Germany
    Eur J Neurol 18:750-5. 2011
    ..e., in a PD stage where dopaminergic decline starts to lead to the occurrence of the characteristic motor symptoms...
  22. ncbi request reprint Neurostimulation of the ventral intermediate thalamic nucleus in inherited myoclonus-dystonia syndrome
    T Trottenberg
    Department of Neurology, Humboldt-University, , Berlin, Germany
    Mov Disord 16:769-71. 2001
    ..This suggests that neurostimulation of the VIM may be an effective treatment for myoclonus in pharmacologically intractable IMDS...
  23. ncbi request reprint Long-term results of deep brain stimulation in a cohort of eight children with isolated dystonia
    P Krause
    Department of Neurology, Charite, University Medicine Berlin, Campus Virchow, Berlin, Germany
    J Neurol 263:2319-2326. 2016
    ..Results confirm that pallidal DBS is a safe and efficacious long-term treatment in children, with overall motor improvement similar to that described in controlled trials in adults...
  24. ncbi request reprint The subthalamic region is activated during valence-related emotional processing in patients with Parkinson's disease
    C Brücke
    Department of Neurology, Charite, Augustenburgerplatz 1, 13533 Berlin, Germany
    Eur J Neurosci 26:767-74. 2007
    ..Our findings suggest involvement of the human STN in valence-related emotional information processing that can potentially be altered during high-frequency stimulation of the STN in PD leading to behavioural complications...
  25. ncbi request reprint Pseudo-bilateral hand motor responses evoked by transcranial magnetic stimulation in patients with deep brain stimulators
    A A Kühn
    Department of Neurology, Charite, Campus Virchow Klinikum, Humboldt University Berlin, Augustenburger Platz 1, 13353, Berlin, Germany
    Clin Neurophysiol 113:341-5. 2002
    ..The aim of this study was to clarify the origin of these ipsilateral responses...
  26. ncbi request reprint Long-term proliferation and dopaminergic differentiation of human mesencephalic neural precursor cells
    A Storch
    Department of Neurology, University of Ulm Medical School, Ulm, Germany
    Exp Neurol 170:317-25. 2001
    ....
  27. doi request reprint Movement-related synchronization of gamma activity is lateralized in patients with dystonia
    Christof Brücke
    Department of Neurology, Campus Virchow, Charite University Medicine Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
    Eur J Neurosci 27:2322-9. 2008
    ..Moreover, the results provide further support for functional distinctions between BG oscillatory activities of different frequency...
  28. ncbi request reprint A randomized trial of botulinum toxin A for treatment of drooling
    A Lipp
    Department of Neurology, Medical Faculty of the Charite, Humboldt University, Berlin, Germany
    Neurology 61:1279-81. 2003
    ..The primary endpoint was achieved with 75 MU BTX-A without treatment-related adverse events, suggesting BTX-A is a safe and effective treatment for patients with sialorrhea...
  29. ncbi request reprint Deep-brain stimulation for Parkinson's disease
    G Deuschl
    Department of Neurology, Christian Albrechts Universitat Kiel, Niemannsweg 147, 24105 Kiel, Germany
    J Neurol 249:III/36-9. 2002
    ..However, prospective studies for this procedure are lacking and some clinical problems may be more easily solved with targeting the internal pallidum or the thalamus. Despite major progress in this field, much work remains to be done...
  30. ncbi request reprint Electrical stimulation of the posteroventral pallidum influences internally guided saccades in Parkinson's disease
    A Straube
    Neurologische Poliklinik, Klinikum Grosshadern, Munich, Germany
    J Neurol 245:101-5. 1998
    ..This finding supports the idea that the oculomotor pathways through the basal ganglia are organized like the somatic motor pathways and that stimulation of the posteroventral pallidum influences both...
  31. ncbi request reprint L -dopa-induced adverse effects in PD and dopamine transporter gene polymorphism
    R Kaiser
    Institute of Clinical Pharmacology, Charite, Humboldt Universitat zu Berlin, Germany
    Neurology 60:1750-5. 2003
    ..To assess whether polymorphisms in the dopamine receptor genes and in the dopamine transporter gene (DAT ) are predictors of adverse effects of L -dopa...
  32. ncbi request reprint Ultrasound perfusion imaging of cysts in the midbrain
    C H Nolte
    Department of Neurology, University Hospital Charite Berlin
    Ultraschall Med 26:527-9. 2005
    ..Cerebral ultrasound perfusion examinations have been focused on the diencephalic plane. We describe perfusion abnormalities in the mesencephalon...
  33. ncbi request reprint High frequency stimulation and temporary inactivation of the subthalamic nucleus reduce quinpirole-induced compulsive checking behavior in rats
    Christine Winter
    Department of Psychiatry and Psychotherapy, Charite Campus Mitte, Germany Department of Neurology, Charite Campus Mitte, Germany
    Exp Neurol 210:217-28. 2008
    ..We conclude that functional inhibition of the STN can alleviate compulsive checking, and suggest the STN as a potential target structure for HFS in the treatment of OCD...
  34. ncbi request reprint [Inhibition of catechol-O-methyltransferase. Optimizing dopaminergic therapy in idiopathic Parkinson syndrome with entacapone]
    G Arnold
    Neurologische Klinik und Poliklinik, Universitatsklinikum Charite, Humboldt Universitat Berlin
    Nervenarzt 71:78-83. 2000
    ..We review data, especially on the remaining COMT inhibitor, entacapone, with regard to pre-clinical and clinical efficacy and safety...
  35. doi request reprint Preoperative treatment with Botulinum Toxin A before total hip arthroplasty in a patient with tetraspasticity: Case report and review of literature
    S Eibach
    Department of Neurology, Charite Universitatsmedizin Berlin, Germany
    NeuroRehabilitation 28:81-3. 2011
    ..This case demonstrates a new preoperative indication for Botulinum Toxin A in patients with an increased muscle tone at the hip who have to undergo total hip joint endoprosthesis to reduce the risk of postoperative luxation...
  36. ncbi request reprint Combined 123I-FP-CIT and 123I-IBZM SPECT for the diagnosis of parkinsonian syndromes: study on 72 patients
    M Plotkin
    Klinik fur Strahlenheilkunde, Campus Virchow Klinikum, Charite Universitatsmedizin, Berlin, Germany
    J Neural Transm (Vienna) 112:677-92. 2005
    ..IBZM SPECT is useful to approve the diagnosis of PSP and MSA although a normal finding cannot exclude an atypical PS. IBZM SPECT seems to be of restricted value in CBD...
  37. doi request reprint Long-term effect on dystonia after pallidal deep brain stimulation (DBS) in three members of a family with a THAP1 mutation
    P Krause
    Department of Neurology, Charite, University Medicine Berlin, Campus Virchow Klinikum, Augustenburger Platz 1, 13353, Berlin, Germany
    J Neurol 262:2739-44. 2015
    ..Overall, our observation supports pallidal DBS as an important treatment option in patients with DYT6 dystonia...
  38. ncbi request reprint Normal cerebral hemodynamic response to orthostasis in Parkinson's disease
    L Niehaus
    Department of Neurology, Charite, Campus Virchow Klinikum, Humboldt University, Berlin, Germany
    Parkinsonism Relat Disord 8:255-9. 2002
    ..It can be concluded that in IPD patients without symptoms of orthostatic dysregulation the autonomic circulatory control is impaired while the cerebral hemodynamic regulation during orthostasis is unaffected...
  39. ncbi request reprint Dopaminergic therapy promotes lateralized motor activity in the subthalamic area in Parkinson's disease
    Alexandros G Androulidakis
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London, UK
    Brain 130:457-68. 2007
    ..These findings suggest that dopaminergic therapy restores a more physiological pattern of reactivity in the STN of patients with Parkinson's disease...
  40. ncbi request reprint Randomized, double-blind, placebo-controlled trial on symptomatic effects of coenzyme Q(10) in Parkinson disease
    Alexander Storch
    Department of Neurology, Technical University of Dresden, Fetscherstrasse 74, 01307 Dresden, Germany
    Arch Neurol 64:938-44. 2007
    ..Coenzyme Q(10) (CoQ(10)) is an electron acceptor bridging mitochondrial complexes I and II/III and a potent antioxidant that consistently partially recovers the function of dopaminergic neurons...
  41. ncbi request reprint A randomized trial of deep-brain stimulation for Parkinson's disease
    Gunther Deuschl
    Christian Albrechts University, Kiel, Germany
    N Engl J Med 355:896-908. 2006
    ..Neurostimulation of the subthalamic nucleus reduces levodopa-related motor complications in advanced Parkinson's disease. We compared this treatment plus medication with medical management...
  42. ncbi request reprint Lesions of dopaminergic neurons in the substantia nigra pars compacta and in the ventral tegmental area enhance depressive-like behavior in rats
    Christine Winter
    Department of Psychiatry and Psychotherapy, Charite Campus Mitte, Germany
    Behav Brain Res 184:133-41. 2007
    ..The effects of citalopram administration on depressive behavior induced by lesions of dopaminergic brain regions furthermore suggest an involvement of serotonergic pathways in dopaminergic cell loss-induced depression...
  43. ncbi request reprint Modulation by dopamine of human basal ganglia involvement in feedback control of movement
    Florian Kempf
    Department of Neurology, Charite University Medicine Berlin, CVK, Berlin, Germany
    Curr Biol 17:R587-9. 2007
    ....
  44. ncbi request reprint Pallidal deep-brain stimulation in primary generalized or segmental dystonia
    Andreas Kupsch
    Charite Universitatsmedizin Berlin, Campus Virchow, Berlin, Germany
    N Engl J Med 355:1978-90. 2006
    ..Neurostimulation of the internal globus pallidus has been shown to be effective in reducing symptoms of primary dystonia. We compared this surgical treatment with sham stimulation in a randomized, controlled clinical trial...
  45. ncbi request reprint Premovement activities in the subthalamic area of patients with Parkinson's disease and their dependence on task
    Florian Kempf
    Department of Neurology, Charite Berlin, Campus Virchow, Germany
    Eur J Neurosci 25:3137-45. 2007
    ..The findings further implicate the human STN in the feedforward organization of movement in premotor circuits. Different aspects of this organization may be preferentially reflected in changes in synchrony at different frequencies...
  46. ncbi request reprint Pallidal deep brain stimulation improves quality of life in segmental and generalized dystonia: results from a prospective, randomized sham-controlled trial
    Joerg Mueller
    Mov Disord 23:131-4. 2008
    ..The open-label extension phase resulted in a significant improvement in all SF-36 domains following 6 months of neurostimulation. These results demonstrate a favorable impact of DBS on HRQoL in primary dystonia...
  47. ncbi request reprint Deep brain stimulation of the subthalamic nucleus: a two-edged sword
    Chiung Chu Chen
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London, UK
    Curr Biol 16:R952-3. 2006
  48. ncbi request reprint Task-related differential dynamics of EEG alpha- and beta-band synchronization in cortico-basal motor structures
    Fabian Klostermann
    Department of Neurology, CBF CVK, Charite University Medicine Berlin, Berlin, Germany
    Eur J Neurosci 25:1604-15. 2007
    ....
  49. ncbi request reprint High frequency stimulation of the subthalamic nucleus modulates neurotransmission in limbic brain regions of the rat
    Christine Winter
    Department of Neurology, Charite Campus Virchow, Berlin, Germany
    Exp Brain Res 185:497-507. 2008
    ..preceding lesion of the VTA seems to prohibit further detection of DA in the NAc. We conclude that STN-HFS significantly affects neurotransmission in the limbic system, which might contribute to explain the non-motor effects of STN-HFS...
  50. doi request reprint The human thalamus processes syntactic and semantic language violations
    Michael Wahl
    Department of Neurology, Charite University Medicine, 12200 Berlin, Germany
    Neuron 59:695-707. 2008
    ..We therefore propose that syntactic and semantic language analysis is primarily realized within cortico-thalamic networks, whereas a cohesive basal ganglia network is not involved in these essential operations of language analysis...
  51. doi request reprint High-frequency stimulation of the subthalamic nucleus suppresses oscillatory beta activity in patients with Parkinson's disease in parallel with improvement in motor performance
    Andrea A Kuhn
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London WC1N 3BG, United Kingdom
    J Neurosci 28:6165-73. 2008
    ..Our findings suggest that HFS may act by modulating pathological patterns of synchronized oscillations, specifically by reduction of pathological beta activity in PD...
  52. doi request reprint Neuropsychological and psychiatric changes after deep brain stimulation for Parkinson's disease: a randomised, multicentre study
    Karsten Witt
    Christian Albrechts University, Kiel, Germany
    Lancet Neurol 7:605-14. 2008
    ..To assess the neuropsychiatric consequences of DBS in patients with PD we did an ancillary protocol as part of a randomised study that compared DBS with the best medical treatment...
  53. doi request reprint Dopaminergic modulation of emotional memory in Parkinson's disease
    Thomas D Hälbig
    Department of Neurology, Charite, Universitatsmedizin Berlin, Campus Virchow Klinikum, 13353, Berlin, Germany
    J Neural Transm (Vienna) 115:1159-63. 2008
    ..These findings demonstrate that emotional memory deficits observed in PD may result from dopaminergic treatment and suggest an involvement of dopaminergic neurotransmission in emotional processing...
  54. doi request reprint Survival and functional recovery of transplanted human dopaminergic neurons into hemiparkinsonian rats depend on the cannula size of the implantation instrument
    Barbara Steiner
    Department of Neurology, Experimental Basal Ganglia Research Charité, University Medicine Berlin, CVK, Augustenburger Platz 1, 13353 Berlin, Germany
    J Neurosci Methods 169:128-34. 2008
    ..Importantly, higher numbers of surviving cells also correlated with a behavioral recovery of the hemiparkinsonian rats...
  55. doi request reprint Subthalamic stimulation increases striatal tyrosine hydroxylase phosphorylation
    Rene Reese
    CNRS UMR 5227, Bordeaux, France
    Neuroreport 19:179-82. 2008
    ..Our results suggest that subthalamic stimulation may increase tyrosine hydroxylase activity via increased phosphorylation...
  56. doi request reprint Is the synchronization between pallidal and muscle activity in primary dystonia due to peripheral afferance or a motor drive?
    Andrew Sharott
    Department of Neurophysiology and Pathophysiology, University Medical Center Hamburg Eppendorf, 20246 Hamburg, Germany
    Brain 131:473-84. 2008
    ..In addition, the net GP drive to muscle is not stable but fluctuates across time, in keeping with the dynamic nature of dystonic muscle activity...
  57. ncbi request reprint Brain parenchyma sonography and 123I-FP-CIT SPECT in Parkinson's disease and essential tremor
    Florian Doepp
    Department of Neurology, University Hospital Charite, Berlin, Germany
    Mov Disord 23:405-10. 2008
    ..TCS allows a reliable differentiation of PD and ET. The TCS SN hyperechogenicity does not correlate with the extent of dopaminergic neuron degeneration...
  58. ncbi request reprint Unilateral lesion of the subthalamic nucleus transiently provokes bilateral subacute glial cell proliferation in the adult rat substantia nigra
    Barbara Steiner
    Department of Neurology, Charite, University Medicine Berlin, Augustenburger Platz 1, 13351 Berlin, Germany
    Neurosci Lett 430:103-8. 2008
    ..No newborn neurons, however, were detected. Thus, we conclude that unilateral ablative STN lesion transiently changes plasticity of neural cell subpopulations in the healthy adult SN of the rat...
  59. ncbi request reprint Placebo-controlled chronic high-frequency stimulation of the subthalamic nucleus preserves dopaminergic nigral neurons in a rat model of progressive Parkinsonism
    Daniel Harnack
    Department of Neurology, Campus Virchow, Charite Universitatsmedizin, Augustenburger Platz 1, Berlin, Germany
    Exp Neurol 210:257-60. 2008
    ..These data provide evidence for the phenotypic rescue of nigral dopamine neurons by long-term STN-HFS in this animal model of PD...
  60. ncbi request reprint Continuous high-frequency stimulation in freely moving rats: development of an implantable microstimulation system
    Daniel Harnack
    Department of Neurology, Campus Virchow, Berlin Germany
    J Neurosci Methods 167:278-91. 2008
    ..In conclusion, chronic HFS with an implantable stimulator can be successfully applied in small animals...
  61. ncbi request reprint Neuronal activity in globus pallidus interna can be synchronized to local field potential activity over 3-12 Hz in patients with dystonia
    Chiung Chu Chen
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square, London, WCIN 3BG, UK
    Exp Neurol 202:480-6. 2006
    ..This lends support to a pathophysiological relationship between LFP activity at 3-12 Hz and dystonia...
  62. ncbi request reprint Elevations in local gamma activity are accompanied by changes in the firing rate and information coding capacity of neurons in the region of the subthalamic nucleus in Parkinson's disease
    Alek Pogosyan
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square, London, WCIN 3BG, UK
    Exp Neurol 202:271-9. 2006
    ..We conclude that overall there was a net elevation in firing rate and potential information coding capacity, assessed in terms of baud, amongst neurons during periods of elevated gamma LFP activity in the subthalamic region...
  63. ncbi request reprint Levodopa-responsive posttraumatic parkinsonism is not associated with changes of echogenicity of the substantia nigra
    Anatol Kivi
    Mov Disord 20:258-60. 2005
  64. ncbi request reprint The effects of electrode material, charge density and stimulation duration on the safety of high-frequency stimulation of the subthalamic nucleus in rats
    Daniel Harnack
    Department of Neurology, Charite Campus Virchow, Berlin, Germany
    J Neurosci Methods 138:207-16. 2004
    ....
  65. ncbi request reprint High-frequency stimulation of the entopeduncular nucleus improves dystonia in dtsz hamsters
    Daniel Harnack
    Department of Neurology, Charite Campus Virchow, Berlin, Germany
    Neuroreport 15:1391-3. 2004
    ..Our results underline the pathophysiological role of the EPN in the dtsz hamster and suggest the suitability of this model to further investigate mechanisms of HFS in dystonia...
  66. ncbi request reprint Subthalamic stimulation differentially modulates declarative and nondeclarative memory
    Thomas D Hälbig
    Department of Neurology, Charite University Medicine Berlin, Campus Virchow Klinikum, Augustenburger Platz 1, D 13353 Berlin, Germany
    Neuroreport 15:539-43. 2004
    ....
  67. ncbi request reprint Subthalamic high frequency stimulation induced rotations are differentially mediated by D1 and D2 receptors
    Olaf Bergmann
    Institute of Pharmacology and Toxicology, Charite Campus Mitte, Humboldt University, Berlin, Germany
    Neuropharmacology 46:974-83. 2004
    ..These findings suggest the nigrostriatal DA-system to be specifically involved in the mediation of STN-HFS-induced motor effects...
  68. ncbi request reprint Comparison of motor effects following subcortical electrical stimulation through electrodes in the globus pallidus internus and cortical transcranial magnetic stimulation
    Andrea A Kuhn
    Department of Neurology, Charite, Humboldt University Berlin, Campus Virchow Klinikum, Augustenburger Platz 1, 13353, Berlin, Germany
    Exp Brain Res 155:48-55. 2004
    ..Furthermore, the present results suggest that the ipsilateral inhibition is predominantly mediated via transcallosal pathways...
  69. ncbi request reprint Motor cortex inhibition induced by acoustic stimulation
    Andrea A Kuhn
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London, UK
    Exp Brain Res 158:120-4. 2004
    ..1+/-4.3%, amplitude: 116.9+/-6.9%). We conclude that a startle-evoked activation of reticulo-cortical projections transiently inhibits the motor cortex...
  70. ncbi request reprint Event-related beta desynchronization in human subthalamic nucleus correlates with motor performance
    Andrea A Kuhn
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square, London WCIN 3BG, UK
    Brain 127:735-46. 2004
    ....
  71. ncbi request reprint Ablation of the subthalamic nucleus protects dopaminergic phenotype but not cell survival in a rat model of Parkinson's disease
    Gesine Paul
    Department of Neurology, Charite, Humboldt University of Berlin, Berlin, Germany
    Exp Neurol 185:272-80. 2004
    ....
  72. ncbi request reprint Deep brain stimulation of subthalamic neurons increases striatal dopamine metabolism and induces contralateral circling in freely moving 6-hydroxydopamine-lesioned rats
    Wassilios Meissner
    Department of Neurology, Charite Campus Virchow Klinikum, Humboldt University Berlin, Augustenburger Platz 1, 13353, Berlin, Germany
    Neurosci Lett 328:105-8. 2002
    ..Taken together, these results suggest that STN-DBS could disinhibit (consequently activate) substantia nigra compacta neurons via inhibition of gamma-aminobutyric acid-ergic substantia nigra reticulata neurons...
  73. ncbi request reprint High frequency stimulation of the entopeduncular nucleus has no effect on striatal dopaminergic transmission
    Wassilios Meissner
    Department of Neurology, Charite Campus Virchow, Humboldt University Berlin, Berlin, Germany
    Neurochem Int 44:281-6. 2004
    ....
  74. ncbi request reprint Patterning of globus pallidus local field potentials differs between Parkinson's disease and dystonia
    Paul Silberstein
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square, London WCIN 3BG, UK
    Brain 126:2597-608. 2003
    ..We conclude that untreated and treated Parkinson's disease and dystonia are characterized by different spatiotemporal patterns of activity in the human pallidum...
  75. ncbi request reprint Behavioural cues are associated with modulations of synchronous oscillations in the human subthalamic nucleus
    David Williams
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square, London WCIN 3BG, UK
    Brain 126:1975-85. 2003
    ....
  76. ncbi request reprint High-frequency stimulation of the subthalamic nucleus enhances striatal dopamine release and metabolism in rats
    Wassilios Meissner
    Department of Neurology, Charite Campus Virchow, Humboldt University Berlin, Germany
    J Neurochem 85:601-9. 2003
    ..We, therefore, conclude that the application of subthalamic high-frequency stimulation could partially compensate for the DA deficit by inducing increased striatal DA release and metabolism...
  77. ncbi request reprint Oscillatory local field potentials recorded from the subthalamic nucleus of the alert rat
    Peter Brown
    Sobell Department of Neurophysiology, Institute of Neurology, London, WCIN 3BG, United Kingdom
    Exp Neurol 177:581-5. 2002
    ....
  78. ncbi request reprint The relationship between oscillatory activity and motor reaction time in the parkinsonian subthalamic nucleus
    David Williams
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square, London WC1N 3BG, UK
    Eur J Neurosci 21:249-58. 2005
    ..The results are consistent with the hypothesis that reductions in 8-30 Hz population synchrony in the STN area are related to the processing required for motor preparation, particularly response selection...
  79. ncbi request reprint Deep brain stimulation in late stage Parkinson's disease: a retrospective cost analysis in Germany
    Wassilios Meissner
    Department of Neurology, Charite Campus Virchow Klinikum, Humboldt University, Augustenburger Platz 1, 13353 Berlin, Germany
    J Neurol 252:218-23. 2005
    ..The present study provides first data of an important number of patients on clinical effectiveness and expenses in relation to STNDBS...
  80. ncbi request reprint Cortico-cortical coupling in Parkinson's disease and its modulation by therapy
    Paul Silberstein
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London, UK
    Brain 128:1277-91. 2005
    ..This mechanistic similarity may underscore the strong clinical correlation between the therapeutic effects of these treatment modalities...
  81. ncbi request reprint Dopamine transporters, D2 receptors, and glucose metabolism in corticobasal degeneration
    Stefanie Klaffke
    Department of Neurology, University Medicine Berlin, Berlin, Germany
    Mov Disord 21:1724-7. 2006
    ..Our results demonstrate that glucose metabolism and DAT are reduced, while D2 receptors may be frequently preserved in CBD...
  82. ncbi request reprint Controlled withdrawal of pramipexole after 6 months of open-label treatment in patients with restless legs syndrome
    Claudia Trenkwalder
    Paracelsus Elena Klinik, Kassel, Germany
    Mov Disord 21:1404-10. 2006
    ..The great majority of adverse events (AEs) were mild or moderate, and of expected types. Augmentation was considered an AE, but in this population of responders it did not occur...
  83. ncbi request reprint Reduction in subthalamic 8-35 Hz oscillatory activity correlates with clinical improvement in Parkinson's disease
    Andrea A Kuhn
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square, London WCIN 3BG, UK
    Eur J Neurosci 23:1956-60. 2006
    ..Our results support a link between levodopa-induced improvements in bradykinesia and rigidity and reductions in population synchrony at frequencies < 35 Hz in the region of the STN in patients with PD...
  84. ncbi request reprint Subthalamic nucleus lesioning inhibits expression and phosphorylation of c-Jun in nigral neurons in the rat's 6-OHDA model of Parkinson's disease
    Christine Winter
    Department of Neurology, Charite University Medicine Berlin, Campus Charite Mitte, Berlin, Germany
    Synapse 60:69-80. 2006
    ....
  85. ncbi request reprint Increased slow oscillatory activity in substantia nigra pars reticulata triggers abnormal involuntary movements in the 6-OHDA-lesioned rat in the presence of excessive extracellular striatal dopamine
    Wassilios Meissner
    Laboratoire de Physiologie et Physiopathologie de la Signalisation Cellulaire, CNRS UMR 5543, Universite Victor Segalen, 146 rue Leo Saignat, 33076 Bordeaux Cedex, France
    Neurobiol Dis 22:586-98. 2006
    ....
  86. ncbi request reprint Subthalamic gamma activity in patients with Parkinson's disease
    Thomas Trottenberg
    Department of Neurology, Charité University Medicine Campus Virchow, Humboldt University, Berlin, Germany
    Exp Neurol 200:56-65. 2006
    ..Gamma band oscillations in the LFP are therefore likely to represent synchronous activity in populations of neurons in the upper STN and bordering zona incerta of patients with PD...
  87. ncbi request reprint Long-term assessment of striatal dopamine transporters in Parkinsonian patients with intrastriatal embryonic mesencephalic grafts
    Oliver Pogarell
    Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
    Eur J Nucl Med Mol Imaging 33:407-11. 2006
    ....
  88. ncbi request reprint Mental chronometry of target detection: human thalamus leads cortex
    Fabian Klostermann
    Neurophysics Group, Department of Neurology, CBF, Charite University Medicine Berlin, Berlin, Germany
    Brain 129:923-31. 2006
    ..We conclude that the human thalamus specifically supports the early recognition of target events and can widely distribute this label through its divergent cortical projections...
  89. ncbi request reprint Modulation of beta oscillations in the subthalamic area during motor imagery in Parkinson's disease
    Andrea A Kuhn
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London, UK
    Brain 129:695-706. 2006
    ....
  90. ncbi request reprint Enriched environment induces cellular plasticity in the adult substantia nigra and improves motor behavior function in the 6-OHDA rat model of Parkinson's disease
    Barbara Steiner
    Max Delbruck Center for Molecular Medicine MDC Berlin Buch, Robert Rossle Str 10, 13125 Berlin, Germany
    Exp Neurol 199:291-300. 2006
    ..Thus, physiological neurogenic and gliogenic stimuli induce significant microenvironmental changes in the adult SN and improve motor behavior in the 6-OHDA lesion model of PD...
  91. ncbi request reprint High doses of pergolide improve clinical global impression in advanced Parkinson's disease:- a preliminary open label study
    Guy Arnold
    Department of Neurology, Charite, University Hospital Berlin, Schumannstrasse 20 21, D 10117 Berlin, Germany
    Arch Gerontol Geriatr 41:239-53. 2005
    ..A possible relationship to the study medication was assumed for two serious adverse events reporting psychosis. We conclude that high doses of pergolide are efficacious in advanced stages of PD if given in appropriate regimens...
  92. ncbi request reprint Reciprocal interactions between oscillatory activities of different frequencies in the subthalamic region of patients with Parkinson's disease
    Noa Fogelson
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London, UK
    Eur J Neurosci 22:257-66. 2005
    ....
  93. ncbi request reprint Frequency dependent effects of subthalamic nucleus stimulation in Parkinson's disease
    Noa Fogelson
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square, London WCIN 3BG, UK
    Neurosci Lett 382:5-9. 2005
    ..This is consistent with the hypothesis that spontaneous activities in these bands might promote bradykinesia...
  94. ncbi request reprint The relationship between local field potential and neuronal discharge in the subthalamic nucleus of patients with Parkinson's disease
    Andrea A Kuhn
    Department of Neurology, Charite Campus Virchow, Humboldt University, Berlin, Germany
    Exp Neurol 194:212-20. 2005
    ..The LFP is therefore likely to represent synchronous activity in populations of neurons in the STN of patients with PD...
  95. ncbi request reprint Dopamine depletion increases the power and coherence of beta-oscillations in the cerebral cortex and subthalamic nucleus of the awake rat
    Andrew Sharott
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square, London WC1N 3BG, UK
    Eur J Neurosci 21:1413-22. 2005
    ..These changes may be important in regulating movement...
  96. ncbi request reprint Ocular flutter in a patient with intracranial hypertension following cerebral venous thrombosis
    Christoph J Ploner
    Klinik fur Neurologie, Charite, Berlin, Germany
    Neurology 59:959. 2002