Affiliation: Humboldt University
- Differential drug-induced mRNA expression of human CYP3A4 compared to CYP3A5, CYP3A7 and CYP3A43Solveigh Krusekopf
Institute of Clinical Pharmacology, Charite, Humboldt University of Berlin, Schumannstr 20 21, D 10098, Berlin, Germany
Eur J Pharmacol 466:7-12. 2003..St. John's wort also increased CYP3A4 mRNA exclusively, leaving CYP3A5 and CYP3A43 unaffected, whereas CYP3A7 was decreased. Depending on the inducer, expression of CYP3A4 is differently regulated from CYP3A5, CYP3A7, and CYP3A43...
- St. John's wort and its constituent hyperforin concordantly regulate expression of genes encoding enzymes involved in basic cellular pathwaysSolveigh Krusekopf
Institute of Clinical Pharmacology, Charite Campus Mitte, Charite University Medical Center, Humboldt University of Berlin, Berlin, Germany
Pharmacogenet Genomics 15:817-29. 2005..The effects of St. John's wort and hyperforin on gene expression were analysed in HepG2 cells by Affymetrix microarray hybridization and real time reverse transcription-PCR...