Glen Kristiansen

Summary

Affiliation: Humboldt University
Country: Germany

Publications

  1. ncbi request reprint Expression profiling of microdissected matched prostate cancer samples reveals CD166/MEMD and CD24 as new prognostic markers for patient survival
    Glen Kristiansen
    Institute of Pathology, Charite University Hospital, Berlin, Germany
    J Pathol 205:359-76. 2005
  2. ncbi request reprint CD24 expression is a new prognostic marker in breast cancer
    Glen Kristiansen
    Institute of Pathology, Charite University Hospital, Berlin D 10117, Germany
    Clin Cancer Res 9:4906-13. 2003
  3. ncbi request reprint Peroxisome proliferator-activated receptor gamma is highly expressed in pancreatic cancer and is associated with shorter overall survival times
    Glen Kristiansen
    Institute of Pathology and Department of Surgery, Charite University Hospital, Berlin, Germany
    Clin Cancer Res 12:6444-51. 2006
  4. ncbi request reprint CD24 expression is a significant predictor of PSA relapse and poor prognosis in low grade or organ confined prostate cancer
    Glen Kristiansen
    Institute of Pathology, Charite University Hospital, Berlin, Germany
    Prostate 58:183-92. 2004
  5. ncbi request reprint Expression of the cell adhesion molecule CD146/MCAM in non-small cell lung cancer
    Glen Kristiansen
    Institute of Pathology, Charite University Hospital, 10117 Berlin, Germany
    Anal Cell Pathol 25:77-81. 2003
  6. ncbi request reprint ALCAM/CD166 is up-regulated in low-grade prostate cancer and progressively lost in high-grade lesions
    Glen Kristiansen
    Institute of Pathology, Charite University Hospital, Berlin, Germany
    Prostate 54:34-43. 2003
  7. ncbi request reprint ADAM9 expression is a significant and independent prognostic marker of PSA relapse in prostate cancer
    Florian R Fritzsche
    Institute of Pathology, Charite Universitatsmedizin Berlin, Berlin, Germany
    Eur Urol 54:1097-106. 2008
  8. ncbi request reprint Expression of the ELAV-like protein HuR in human prostate carcinoma is an indicator of disease relapse and linked to COX-2 expression
    Silvia Niesporek
    Institute of Pathology, Charite Universitatsmedizin Berlin, Campus Mitte, Chariteplatz 1, Berlin, Germany
    Int J Oncol 32:341-7. 2008
  9. ncbi request reprint Polo-like kinase isoforms in breast cancer: expression patterns and prognostic implications
    Wilko Weichert
    Institute of Pathology, Charite University Hospital, Schumannstrasse 20 21, 10117, Berlin, Germany
    Virchows Arch 446:442-50. 2005
  10. doi request reprint Diagnostic and prognostic implications of microRNA profiling in prostate carcinoma
    Annika Schaefer
    Department of Biology, Free University, Berlin, Germany
    Int J Cancer 126:1166-76. 2010

Detail Information

Publications96

  1. ncbi request reprint Expression profiling of microdissected matched prostate cancer samples reveals CD166/MEMD and CD24 as new prognostic markers for patient survival
    Glen Kristiansen
    Institute of Pathology, Charite University Hospital, Berlin, Germany
    J Pathol 205:359-76. 2005
    ..7, p = 0.006) in a Cox regression model, and was also superior to conventional markers. This combination of molecular markers thus appears to allow improved prediction of patient prognosis, but should be validated in larger studies...
  2. ncbi request reprint CD24 expression is a new prognostic marker in breast cancer
    Glen Kristiansen
    Institute of Pathology, Charite University Hospital, Berlin D 10117, Germany
    Clin Cancer Res 9:4906-13. 2003
    ..We aimed to evaluate CD24 protein expression in breast cancer and to correlate to clinicopathological data including patient survival...
  3. ncbi request reprint Peroxisome proliferator-activated receptor gamma is highly expressed in pancreatic cancer and is associated with shorter overall survival times
    Glen Kristiansen
    Institute of Pathology and Department of Surgery, Charite University Hospital, Berlin, Germany
    Clin Cancer Res 12:6444-51. 2006
    ..We aimed to clarify the expression patterns of PPARgamma in pancreatic ductal carcinomas and to correlate these to clinicopathologic variables, including patient survival...
  4. ncbi request reprint CD24 expression is a significant predictor of PSA relapse and poor prognosis in low grade or organ confined prostate cancer
    Glen Kristiansen
    Institute of Pathology, Charite University Hospital, Berlin, Germany
    Prostate 58:183-92. 2004
    ..Evaluating public expression data of prostate cancer, we found an upregulation of the candidate gene CD24...
  5. ncbi request reprint Expression of the cell adhesion molecule CD146/MCAM in non-small cell lung cancer
    Glen Kristiansen
    Institute of Pathology, Charite University Hospital, 10117 Berlin, Germany
    Anal Cell Pathol 25:77-81. 2003
    ..We conclude, that MCAM is expressed in a high proportion of NSCLC and might be predictive of shortened patient survival in adenocarcinomas of the lung. Colour figure can be viewed on http://www.esacp.org/acp/2003/25-2/kristiansen.htm..
  6. ncbi request reprint ALCAM/CD166 is up-regulated in low-grade prostate cancer and progressively lost in high-grade lesions
    Glen Kristiansen
    Institute of Pathology, Charite University Hospital, Berlin, Germany
    Prostate 54:34-43. 2003
    ..We aimed to clarify the expression patterns of ALCAM in normal and malignant prostate tissue...
  7. ncbi request reprint ADAM9 expression is a significant and independent prognostic marker of PSA relapse in prostate cancer
    Florian R Fritzsche
    Institute of Pathology, Charite Universitatsmedizin Berlin, Berlin, Germany
    Eur Urol 54:1097-106. 2008
    ....
  8. ncbi request reprint Expression of the ELAV-like protein HuR in human prostate carcinoma is an indicator of disease relapse and linked to COX-2 expression
    Silvia Niesporek
    Institute of Pathology, Charite Universitatsmedizin Berlin, Campus Mitte, Chariteplatz 1, Berlin, Germany
    Int J Oncol 32:341-7. 2008
    ..Our results point to a potential prognostic role of HuR expression in prostate cancer diagnostics and propose HuR as a future therapeutic target in prostate cancer therapy...
  9. ncbi request reprint Polo-like kinase isoforms in breast cancer: expression patterns and prognostic implications
    Wilko Weichert
    Institute of Pathology, Charite University Hospital, Schumannstrasse 20 21, 10117, Berlin, Germany
    Virchows Arch 446:442-50. 2005
    ..Therefore, in vivo inhibition of PLK family members might represent a rewarding approach in the development of new anticancer drugs for this tumor entity...
  10. doi request reprint Diagnostic and prognostic implications of microRNA profiling in prostate carcinoma
    Annika Schaefer
    Department of Biology, Free University, Berlin, Germany
    Int J Cancer 126:1166-76. 2010
    ..Thus, differential miRNAs in prostate cancer are useful diagnostic and prognostic indicators. This study provides a solid basis for further functional analyses of miRNAs in prostate cancer...
  11. ncbi request reprint Molecular profiling of laser-microdissected matched tumor and normal breast tissue identifies karyopherin alpha2 as a potential novel prognostic marker in breast cancer
    Edgar Dahl
    Institute of Pathology, University Hospital of the RWTH Aachen, Aachen, Germany
    Clin Cancer Res 12:3950-60. 2006
    ..The aim of the present study was to identify human genes that might prove useful in the diagnosis and therapy of primary breast cancer...
  12. ncbi request reprint Overexpression of cyclooxygenase-2 in human prostate carcinoma and prostatic intraepithelial neoplasia-association with increased expression of Polo-like kinase-1
    Carsten Denkert
    Institute of Pathology, Charite Hospital, Berlin, Germany
    Prostate 67:361-9. 2007
    ..Cyclooxygenases (COX) as well as Polo-like kinases (PLK) are involved in proliferation and cell cycle regulation and have been suggested for preventive and therapeutic approaches in prostate carcinoma...
  13. ncbi request reprint Overexpression of Polo-like kinase 1 is a common and early event in pancreatic cancer
    Wilko Weichert
    Institute of Pathology, Charite University Hospital, Berlin, Germany
    Pancreatology 5:259-65. 2005
    ..Therefore, PLK1 has been proposed as a new target for antineoplastic treatment strategies...
  14. pmc Wnt signalling in human breast cancer: expression of the putative Wnt inhibitor Dickkopf-3 (DKK3) is frequently suppressed by promoter hypermethylation in mammary tumours
    Jürgen Veeck
    Molecular Oncology Group, Institute of Pathology, University Hospital of the RWTH, Aachen, Germany
    Breast Cancer Res 10:R82. 2008
    ....
  15. pmc Expression analysis of mammaglobin A (SCGB2A2) and lipophilin B (SCGB1D2) in more than 300 human tumors and matching normal tissues reveals their co-expression in gynecologic malignancies
    Menelaos Zafrakas
    Institute of Pathology, University Hospital Aachen, RWTH Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    BMC Cancer 6:88. 2006
    ....
  16. doi request reprint KLK15 is a prognostic marker for progression-free survival in patients with radical prostatectomy
    Anja Rabien
    Department of Urology, Charite Universitatsmedizin Berlin, Campus Charite Mitte, Berlin, Germany
    Int J Cancer 127:2386-94. 2010
    ..802, 95% confidence interval 1.037-3.132, p = 0.037). We suggest KLK15 as a new independent tumour marker for patients at risk for disease progression after radical prostatectomy...
  17. doi request reprint Sarcosine in prostate cancer tissue is not a differential metabolite for prostate cancer aggressiveness and biochemical progression
    Florian Jentzmik
    Department of Urology, University Hospital Charite, University Medicine, Berlin, Germany
    J Urol 185:706-11. 2011
    ..We reevaluated sarcosine in prostate cancer tissue samples as a potential indicator of tumor aggressiveness, and as a predictor of recurrence-free survival...
  18. pmc High class I HDAC activity and expression are associated with RelA/p65 activation in pancreatic cancer in vitro and in vivo
    Annika Lehmann
    Institute of Pathology, Charite University Hospital, Berlin, Germany
    BMC Cancer 9:395. 2009
    ..The strong association between aberrant HDAC activity and the occurrence of cancer has led to the development of a variety of HDAC inhibitors (HDIs), which emerge as promising new targeted anticancer therapeutics...
  19. pmc ADAM9 is highly expressed in renal cell cancer and is associated with tumour progression
    Florian R Fritzsche
    Institute of Surgical Pathology, Universitatsmedizin Berlin, Berlin, Germany
    BMC Cancer 8:179. 2008
    ..We evaluated the expression of ADAM9 on protein and transcript level in a clinico-pathologically characterized renal cell cancer cohort...
  20. doi request reprint ERG rearrangement in small cell prostatic and lung cancer
    Veit J Scheble
    Institute of Pathology, University Hospital Tuebingen, Tuebingen, Germany
    Histopathology 56:937-43. 2010
    ..The aim of our study was to determine whether the ERG rearrangement commonly observed in acinar prostatic cancer can distinguish small cell prostatic cancer from small cell lung cancer samples...
  21. ncbi request reprint Expression of the ELAV-like protein HuR is associated with higher tumor grade and increased cyclooxygenase-2 expression in human breast carcinoma
    Carsten Denkert
    Institute of Pathology, Charite Hospital, Berlin, Germany
    Clin Cancer Res 10:5580-6. 2004
    ..Cell culture studies have shown that the mRNA of cyclooxygenase (COX)-2 can be stabilized by HuR...
  22. doi request reprint Rearrangement of the ETS genes ETV-1, ETV-4, ETV-5, and ELK-4 is a clonal event during prostate cancer progression
    Zaki Shaikhibrahim
    Institute of Pathology, University Hospital Bonn, 53127 Bonn, Germany
    Hum Pathol 43:1910-6. 2012
    ..Our findings suggest that rearrangement of the less frequent ETS genes is a clonal event during prostate cancer progression...
  23. doi request reprint High expression of KLK14 in prostatic adenocarcinoma is associated with elevated risk of prostate-specific antigen relapse
    Anja Rabien
    Department of Urology, Charite Universitatsmedizin Berlin, CCM, Berlin, Germany
    Tumour Biol 29:1-8. 2008
    ..It is the aim of this study to analyze the clinical value of immunohistochemical expression of KLK14 in prostate cancer tissue samples...
  24. ncbi request reprint Increased CD59 protein expression predicts a PSA relapse in patients after radical prostatectomy
    Chuanliang Xu
    Department of Urology, Charite University Hospital, Berlin, Germany
    Prostate 62:224-32. 2005
    ..Since a comprehensive investigation of CD59 expression in prostate cancer has not been conducted yet, we aimed to determine the significance of CD59 expression in prostate cancer...
  25. ncbi request reprint Polo-like kinase 1 expression is a prognostic factor in human colon cancer
    Wilko Weichert
    Institute of Pathology, Charite University Hospital, Schumannstrabe 20 21, Berlin 10117, Germany
    World J Gastroenterol 11:5644-50. 2005
    ..To clarify the expression patterns and prognostic implications of the mitotic regulator Polo-like kinase 1 (PLK1) in colon cancer...
  26. doi request reprint Comparison of p40 (ΔNp63) and p63 expression in prostate tissues--which one is the superior diagnostic marker for basal cells?
    Verena Sailer
    Institute of Pathology, University Hospital of Bonn, Bonn, Germany
    Histopathology 63:50-6. 2013
    ..Recently, it has been suggested that the p63 isoform p40 might be more specific as a basal cell marker. In this study we compare the staining characteristics of p63 and p40 in normal and malignant prostate tissues...
  27. pmc Frequent expression loss of Inter-alpha-trypsin inhibitor heavy chain (ITIH) genes in multiple human solid tumors: a systematic expression analysis
    Alexander Hamm
    Institute of Pathology, University Hospital of RWTH Aachen, Aachen, Germany
    BMC Cancer 8:25. 2008
    ..So far, ITIH molecules have been shown to play a particularly important role in inflammation and carcinogenesis...
  28. ncbi request reprint Cytoplasmic CD24 expression in colorectal cancer independently correlates with shortened patient survival
    Wilko Weichert
    Institute of Pathology and Tumor Center, Charite University Hospital, Berlin, Germany
    Clin Cancer Res 11:6574-81. 2005
    ..We aimed to clarify the expression patterns of CD24 in colorectal cancer and to correlate these to clinicopathologic variables including patient survival...
  29. ncbi request reprint Hepsin is highly over expressed in and a new candidate for a prognostic indicator in prostate cancer
    Carsten Stephan
    Department of Urology, University Hospital Charite, Humboldt University, Berlin, Germany
    J Urol 171:187-91. 2004
    ..We quantitatively analyzed hepsin gene expression with real-time polymerase chain reaction and calculated its relationships with clinicopathological parameters in a large cohort of samples...
  30. ncbi request reprint Loss of PDCD4 expression in human lung cancer correlates with tumour progression and prognosis
    Yuan Chen
    Institute of Pathology, University Hospital Charite, Humboldt University, Schumannstrasse 20 21, D 10098 Berlin, Germany
    J Pathol 200:640-6. 2003
    ..These data suggest that the loss of PDCD4 expression is a prognostic factor in lung cancer and may correlate with tumour progression...
  31. ncbi request reprint Expression of CD24 in adenocarcinomas of the pancreas correlates with higher tumor grades
    Juliane Jacob
    Institute of Pathology, Charite University Hospital, Berlin, Germany
    Pancreatology 4:454-60. 2004
    ..We aimed to evaluate CD24 protein expression in pancreatic adenocarcinomas and to correlate it to clinicopathological data including patient survival...
  32. doi request reprint Loss of SLC45A3 protein (prostein) expression in prostate cancer is associated with SLC45A3-ERG gene rearrangement and an unfavorable clinical course
    Sven Perner
    Institute of Pathology, University Hospital of Bonn, Bonn, Germany
    Int J Cancer 132:807-12. 2013
    ..This study also confirms that ERG protein expression is predominantly found in prostate carcinomas with ERG gene rearrangement and does not occur in benign glands...
  33. ncbi request reprint Polo-like kinase 1 is overexpressed in prostate cancer and linked to higher tumor grades
    Wilko Weichert
    Institute of Pathology, Charite University Hospital, Berlin, Germany
    Prostate 60:240-5. 2004
    ..Moreover, several studies reported an overexpression of PLK1 in human malignancies compared to the corresponding tissue of origin...
  34. doi request reprint CD146 protein in prostate cancer: revisited with two different antibodies
    Florian Rudolf Fritzsche
    Institute of Pathology, Universitatsmedizin Berlin, Berlin, Germany
    Pathology 40:457-64. 2008
    ..We aimed to evaluate the expression of CD146 in prostate cancer by immunohistochemistry in a clinically characterised study cohort to evaluate its prognostic properties...
  35. doi request reprint Relevance of cohort design for studying the frequency of the ERG rearrangement in prostate cancer
    Martin Braun
    Institute of Pathology, Comprehensive Cancer Centre, University Hospital of Tuebingen, Tuebingen, Germany
    Histopathology 58:1028-36. 2011
    ..As the reason for this variability is unknown, our aim was to investigate the ERG rearrangement frequency with a cohort design...
  36. ncbi request reprint Quantification of protein expression in cells and cellular subcompartments on immunohistochemical sections using a computer supported image analysis system
    Martin Braun
    Institute of Pathology, and Department of Prostate Cancer Research, University Hospital of Bonn, Bonn, Germany
    Histol Histopathol 28:605-10. 2013
    ..Further, since the digital analysis is precise and reproducible, computer supported protein quantification might help to overcome intra- and interobserver variability and increase objectivity of IHC based protein assessment...
  37. pmc Suitable reference genes for relative quantification of miRNA expression in prostate cancer
    Annika Schaefer
    Department of Urology, University Hospital Charite, Berlin, Germany
    Exp Mol Med 42:749-58. 2010
    ..We recommend using hsa-miR-130b or the geometric mean of hsa-miR-130b and small RNA RNU6-2 for normalization in miRNA expression studies of prostate cancer...
  38. ncbi request reprint Quantitative analysis of kallikrein 15 gene expression in prostate tissue
    Carsten Stephan
    Department of Urology, University Hospital Charite, Humboldt University, Berlin, Germany
    J Urol 169:361-4. 2003
    ..We quantitatively measured and compared gene expression of KLK15 in malignant and benign prostate tissues...
  39. pmc Class I histone deacetylases 1, 2 and 3 are highly expressed in renal cell cancer
    Florian R Fritzsche
    Institute of Pathology, Charite Universitatsmedizin, Berlin, Germany
    BMC Cancer 8:381. 2008
    ..The over-expression of these proteins and their known functions in malignant neoplasms has led to the development of HDAC inhibitors (HDI) as new anti-neoplastic drugs. However, little is known about HDAC expression in renal cell cancer...
  40. ncbi request reprint Prognostic relevance of AGR2 expression in breast cancer
    Florian Rudolf Fritzsche
    Institute of Pathology and Breast Centre, Charite, Universitatsmedizin Berlin, Berlin, Germany
    Clin Cancer Res 12:1728-34. 2006
    ..We aimed to evaluate the expression of the human anterior gradient-2 (AGR2) in breast cancer on RNA and protein level and to correlate it with clinicopathologic data, including patient survival...
  41. ncbi request reprint KPNA2 protein expression in invasive breast carcinoma and matched peritumoral ductal carcinoma in situ
    Anja Dankof
    Institute of Pathology, Campus Charite Mitte, Charite, Universitatsmedizin Berlin, Chariteplatz 1, 10098 Berlin, Germany
    Virchows Arch 451:877-81. 2007
    ..Additionally, KPNA2 is overexpressed in DCIS, particularly high grade lesions, which emphasizes its potential role in carcinogenesis of invasive breast carcinomas...
  42. doi request reprint Development and clinical validation of a real-time PCR assay for PITX2 DNA methylation to predict prostate-specific antigen recurrence in prostate cancer patients following radical prostatectomy
    Dimo Dietrich
    Institute of Pathology, University Hospital Bonn, Bonn, Germany
    J Mol Diagn 15:270-9. 2013
    ..This assay might aid in risk stratification and support the decision-making process when determining whether a patient might benefit from adjuvant treatment after radical prostatectomy...
  43. doi request reprint ERG rearrangement in local recurrences compared to distant metastases of castration-resistant prostate cancer
    Veit J Scheble
    Institute of Pathology, University Hospital Tuebingen, Tuebingen, Germany
    Virchows Arch 461:157-62. 2012
    ..The ERG rearrangement occurred at a lower frequency in distant metastatic prostate cancer compared to local recurrent castration-resistant prostate cancer...
  44. pmc In search of suitable reference genes for gene expression studies of human renal cell carcinoma by real-time PCR
    Monika Jung
    Department of Urology, Charite Universitatsmedizin Berlin, Campus Charite Mitte, Berlin, Germany
    BMC Mol Biol 8:47. 2007
    ..To remedy this situation, 10 housekeeping genes for normalizing purposes of RT-PCR measurements already recommended in various studies were examined with regard to their usefulness as reference genes...
  45. ncbi request reprint Plasma osteopontin in comparison with bone markers as indicator of bone metastasis and survival outcome in patients with prostate cancer
    Azizbek Ramankulov
    Department of Urology, Charite University Medicine Berlin, Campus Charite Mitte, Berlin, Germany
    Prostate 67:330-40. 2007
    ....
  46. doi request reprint Identification of stanniocalcin 2 as prognostic marker in renal cell carcinoma
    Hellmuth A Meyer
    Department of Urology, Charite University Medicine Berlin, Campus Charite Mitte, Berlin, Germany
    Eur Urol 55:669-78. 2009
    ..For an individualized therapy in renal cell carcinoma (RCC), there is a clear need for novel prognostic biomarkers to ensure adequate risk stratification and help with the choice of therapy options...
  47. ncbi request reprint mRNA expression of the five membrane-type matrix metalloproteinases MT1-MT5 in human prostatic cell lines and their down-regulation in human malignant prostatic tissue
    Monika Jung
    Department of Urology, University Hospital Charite, Humboldt University Berlin, Berlin, Germany
    Prostate 55:89-98. 2003
    ....
  48. pmc CD24 is expressed in ovarian cancer and is a new independent prognostic marker of patient survival
    Glen Kristiansen
    Institute of Pathology, Charite Hospital, Berlin, Germany
    Am J Pathol 161:1215-21. 2002
    ..Our data suggest that the expression of CD24 as detected by immunohistochemistry is a new independent molecular marker for shortened survival time of patients with epithelial ovarian carcinomas...
  49. ncbi request reprint The membrane proteases adams and hepsin are differentially expressed in renal cell carcinoma. Are they potential tumor markers?
    Andreas Roemer
    Department of Urology, University Hospital Charite, Humboldt University, Berlin, Germany
    J Urol 172:2162-6. 2004
    ..We assessed the expression of various ADAMs and of hepsin in human renal cell carcinoma (RCC), and correlated expression with clinicopathological data...
  50. doi request reprint DNA methylation of the homeobox genes PITX2 and SHOX2 predicts outcome in non-small-cell lung cancer patients
    Dimo Dietrich
    Institute of Pathology, University Hospital Bonn, Bonn, Germany
    Diagn Mol Pathol 21:93-104. 2012
    ..DNA methylation of PITX2 and SHOX2 is an independent prognostic biomarker for disease progression in non-small-cell lung cancer patients...
  51. ncbi request reprint In situ gene expression of urokinase-type plasminogen activator and its receptor in transitional cell carcinoma of the human bladder
    Venugopal Bhuvarahamurthy
    Department of Urology, University Hospital Charite, Humboldt University, Berlin, Germany
    Oncol Rep 12:909-13. 2004
    ..Statistical significance was reached for uPAR-antigen compared to tumor stage (p=0.025). We conclude that higher expression of uPA and uPAR could indicate a more aggressive phenotype of TCC...
  52. ncbi request reprint Tissue pretreatment with formic acid might lower HercepTest scores in breast cancer
    Florian R Fritzsche
    Institute of Pathology, Charité Universitätmedizin Berlin, Charité Platz 1 3, 10117 Berlin
    Diagn Mol Pathol 15:237-42. 2006
    ..In these cases, a c-erbB2-FISH analysis should be performed. For the immunostaining of hormone receptors in breast cancer, formic acid pretreatment can be applied without negative effects on the sensitivity or specificity of the assay...
  53. pmc Brain-type and liver-type fatty acid-binding proteins: new tumor markers for renal cancer?
    Angelika Tölle
    Department of Urology, Charite Universitatsmedizin Berlin, Berlin, Germany
    BMC Cancer 9:248. 2009
    ..We examined the level of brain-type (B) and liver-type (L) FABP mRNA and the protein expression profiles of both FABPs in renal cell carcinoma...
  54. doi request reprint Claudin-1 protein expression is a prognostic marker of patient survival in renal cell carcinomas
    Florian R Fritzsche
    Institute of Pathology, Charite Universitatsmedizin Berlin, Berlin, Germany
    Clin Cancer Res 14:7035-42. 2008
    ..We aimed to assess the diagnostic or prognostic significance of claudin-1 expression in renal cell carcinoma and to correlate the expression of claudin-1 with clinical, histopathologic, and prognostic parameters in renal cell carcinoma...
  55. doi request reprint Tissue metabolite profiling identifies differentiating and prognostic biomarkers for prostate carcinoma
    Klaus Jung
    Department of Urology, University Hospital Charite, Schumannstraß 20 21, 10117 Berlin, Germany Berlin Institute for Urologic Research, Schumannstraße 20 21, 10117 Berlin, Germany
    Int J Cancer 133:2914-24. 2013
    ..This study proved that metabolites in PCa tissue can be used, in combination with traditional clinicopathological factors, as promising diagnostic and prognostic tools. ..
  56. ncbi request reprint CD10 expression in non-small cell lung cancer
    Glen Kristiansen
    Institute of Pathology, Charite University Hospital, Berlin, Germany
    Anal Cell Pathol 24:41-6. 2002
    ..We conclude that a diagnostic use of CD10 immunostaining in NSCLC is unlikely...
  57. ncbi request reprint An artificial neural network considerably improves the diagnostic power of percent free prostate-specific antigen in prostate cancer diagnosis: results of a 5-year investigation
    Carsten Stephan
    Department of Urology, University Hospital Charite, Humboldt University, Berlin, Germany
    Int J Cancer 99:466-73. 2002
    ..For PSA 4-10 ng/mL, we recommend a first-time biopsy based on the ANN at the 90% sensitivity level. Use of an ANN enhances the %fPSA performance to further reduce the number of unnecessary biopsies within the PSA range 2-10 ng/ml...
  58. ncbi request reprint Systematic identification and molecular characterization of genes differentially expressed in breast and ovarian cancer
    Edgar Dahl
    Institute of Pathology, RWTH Aachen, Germany
    J Pathol 205:21-8. 2005
    ..The majority of these differentially expressed genes have not been described previously in the context of breast and ovarian cancer, and may constitute novel diagnostic markers for these tumour entities...
  59. ncbi request reprint Serum human glandular kallikrein 2 (hK2) for distinguishing stage and grade of prostate cancer
    Carsten Stephan
    Department of Urology, University Hospital Charite Berlin, Berlin, Germany
    Int J Urol 13:238-43. 2006
    ..We investigated the role of hK2 serum values for predicting pathological stage, grade and Gleason score...
  60. ncbi request reprint Elevated expression of cyclooxygenase-2 is a negative prognostic factor for disease free survival and overall survival in patients with breast carcinoma
    Carsten Denkert
    Institute of Pathology, Charite Hospital, Berlin, Germany
    Cancer 97:2978-87. 2003
    ....
  61. ncbi request reprint ADAM8 expression in prostate cancer is associated with parameters of unfavorable prognosis
    Florian R Fritzsche
    Department of Pathology, Charite Universitatsmedizin Berlin, Schumannstrasse 20 21, 10117 Berlin, Germany
    Virchows Arch 449:628-36. 2006
    ..Therefore, despite of its significant association with conventional parameters of an unfavorable prognosis, ADAM8 adds only limited information to the conventional histopathological assessment of prostate cancer...
  62. ncbi request reprint Profile of differentially expressed genes after transfer of chromosome 17 into the breast cancer cell line CAL51
    Christiane Klebig
    Institute of Pathology, University Hospital Charite, Humboldt University, D 10117 Berlin, Germany
    Genes Chromosomes Cancer 44:233-46. 2005
    ....
  63. doi request reprint Diagnostic and prognostic potential of differentially expressed miRNAs between metastatic and non-metastatic renal cell carcinoma at the time of nephrectomy
    Zofia Wotschofsky
    Department of Urology, University Hospital Charite, Berlin, Germany
    Clin Chim Acta 416:5-10. 2013
    ..We aimed to evaluate the prognostic potential of selected microRNAs in primary clear cell renal cell carcinomas (ccRCC) as predictors of tumor recurrence after radical nephrectomy...
  64. doi request reprint MicroRNAs and cancer: current state and future perspectives in urologic oncology
    Annika Schaefer
    Department of Urology, University Hospital Charite, Berlin, Germany
    Urol Oncol 28:4-13. 2010
    ..Detailed understanding of the characteristic miRNA abnormalities could contribute to novel approaches in diagnosis and treatment of urological tumors...
  65. ncbi request reprint Anaplastic large-cell non-Hodgkin's lymphoma of the breast in periprosthetic localisation 32 years after treatment for primary breast cancer--a case report
    Florian Rudolf Fritzsche
    Institute of Pathology, Charite Universitatsmedizin Berlin, Schumannstr 20 21, 10117 Berlin, Germany
    Virchows Arch 449:561-4. 2006
    ..The immunoprofile of the tumor showed negativity for cytokeratins and led to the diagnosis of a CD30-positive anaplastic large cell lymphoma...
  66. pmc H-REV107-1 stimulates growth in non-small cell lung carcinomas via the activation of mitogenic signaling
    Irina Nazarenko
    Institute of Pathology, Charité Universitaetsmedizin Berlin Schumannstr 20 21, D 10117 Berlin, Germany
    Am J Pathol 169:1427-39. 2006
    ....
  67. ncbi request reprint Systematic characterisation of GABRP expression in sporadic breast cancer and normal breast tissue
    Menelaos Zafrakas
    Institute of Pathology, University Hospital of the RWTH, Aachen, Germany
    Int J Cancer 118:1453-9. 2006
    ..Altogether, these data suggest that GABRP is progressively down-regulated with tumour-progression, and that it may be useful as a prognostic marker in breast cancer...
  68. ncbi request reprint Surgical strategies and predictors of outcome for malignant neuroendocrine tumors of the pancreas
    Marcus Bahra
    General, Visceral and Transplantation Surgery Clinic, Charite, Campus Virchow Hospital, Humboldt University, Berlin, Germany
    J Gastroenterol Hepatol 22:930-5. 2007
    ..The aim of this study was to retrospectively review all patients who underwent pancreatic resection for malignant neuroendocrine tumor of the pancreas at the one department from 1989 to 2003...
  69. doi request reprint Report of a metaplastic carcinoma of the breast with multi-directional differentiation: an adenoid cystic carcinoma, a spindle cell carcinoma and melanoma
    Aurelia Noske
    Institute of Pathology, Charite University Hospital Berlin, Campus Mitte, Chariteplatz 1, Berlin 10117, Germany
    Virchows Arch 452:575-9. 2008
    ..This is the first report on a metaplastic carcinoma of the breast presenting as an admixture of an adenoid cystic carcinoma and melanoma...
  70. ncbi request reprint Expression of cathepsins B, H, and L and their inhibitors as markers of transitional cell carcinoma of the bladder
    Andrea Staack
    Department of Urology, University Hospital Charite, Humboldt University Berlin, Berlin, Germany
    Urology 63:1089-94. 2004
    ..However, no data are available in cell lysates and supernatants of differently differentiated human bladder cell lines or in noncancerous and cancerous bladder tissue...
  71. doi request reprint MicroRNA profiling of clear cell renal cell cancer identifies a robust signature to define renal malignancy
    Monika Jung
    Department of Urology, Charite Universitatsmedizin, Berlin, Germany
    J Cell Mol Med 13:3918-28. 2009
    ..A combination of miR-141 and miR-155 resulted in a 97% overall correct classification of samples. The presented differential microRNA pattern provides a solid basis for further validation, including functional studies...
  72. ncbi request reprint Differential expression of matrix metalloproteinases and their tissue inhibitors in human primary cultured prostatic cells and malignant prostate cell lines
    Ju Zhang
    Department of Urology, University Hospital Charite, Humboldt University Berlin, Berlin, Germany
    Prostate 50:38-45. 2002
    ..The aim was to investigate the expression of matrix metalloproteinases (MMPs), membrane type MMPs (MT-MMPs), and their inhibitors (TIMPs) in human primary cultured prostatic cells and malignant prostate cell lines...
  73. ncbi request reprint Loss of SFRP1 is associated with breast cancer progression and poor prognosis in early stage tumors
    Eva Klopocki
    Freie Universitat Berlin, Berlin, Germany
    Int J Oncol 25:641-9. 2004
    ..04). In conclusion, expression of SFRP1 is commonly lost in breast cancer. SFRP1 expression might be useful as a novel prognostic marker in early stage breast cancer...
  74. pmc Down-regulation of the pro-apoptotic XIAP associated factor-1 (XAF1) during progression of clear-cell renal cancer
    Carsten Kempkensteffen
    Institute of Surgical Pathology, Universitatsspital Zurich, 8091 Zurich, Switzerland
    BMC Cancer 9:276. 2009
    ..However, little is yet known about its potential implication in the tumour biology of clear-cell renal cell cancer (ccRCC)...
  75. ncbi request reprint Serum (-5, -7) proPSA for distinguishing stage and grade of prostate cancer
    Carsten Stephan
    Departments of Neurology, Universitätsmedizin Charité Berlin, CCM, Germany
    Anticancer Res 27:1833-6. 2007
    ..ProPSA has been suggested for the detection of preferentially aggressive prostate cancer (PCa). We report on the use of proPSA and free PSA to enhance preoperative staging and grading...
  76. ncbi request reprint Complications, urinary continence, and oncologic outcome of 1000 laparoscopic transperitoneal radical prostatectomies-experience at the Charité Hospital Berlin, Campus Mitte
    Michael Lein
    Department of Urology, Charité Hospital Berlin, Campus Mitte, University Medicine Berlin, Germany
    Eur Urol 50:1278-82; discussion 1283-4. 2006
    ..This study was initiated to evaluate LRP with regard to complications, urinary continence, and oncologic outcome...
  77. ncbi request reprint Gene expression studies in prostate cancer tissue: which reference gene should be selected for normalization?
    Falk Ohl
    Department of Urology, Charite Universitatsmedizin Berlin, Campus Mitte, Schumannstrasse 20 21, 10098 Berlin, Germany
    J Mol Med (Berl) 83:1014-24. 2005
    ....
  78. ncbi request reprint Neuroendocrine tumor of the pancreas and bilateral adrenal pheochromocytomas. A rare manifestation of von Hippel-Lindau disease in childhood
    Jan M Langrehr
    Department for General, Visceral and Transplantation Surgery, Charite, Campus Virchow Clinic, 13353 Berlin, Germany
    J Pediatr Surg 42:1291-4. 2007
    ..This is the first report on the combination of a neuroendocrine pancreatic tumor with adrenal pheochromocytoma in a pediatric patient with von Hippel-Lindau (VHL) disease...
  79. doi request reprint Where we publish : an analysis of the publications of German institutes of pathology
    Florian Rudolf Fritzsche
    Institute of Pathology, Charite Universitatsmedizin Berlin, Charite Campus Mitte, Chariteplatz 1, 10117 Berlin, Germany
    Virchows Arch 452:363-8. 2008
    ..However, the general notion that pathology journals are the most important communication medium of pathology research was affirmed...
  80. ncbi request reprint Increased cell-free DNA in plasma of patients with metastatic spread in prostate cancer
    Klaus Jung
    Department of Urology, University Hospital Charite, Humboldt University, Schumannstrasse 20 21, D 10098 Berlin, Germany
    Cancer Lett 205:173-80. 2004
    ..It can be concluded that plasma DNA has a limited validity as metastatic marker in PCa patients but follow-up studies combined with the investigation of tumor-related characteristics of plasma DNA would be reasonable...
  81. ncbi request reprint Different prostate-specific antigen assays give different results on the same blood sample: an obstacle to recommending uniform limits for prostate biopsies
    Carsten Stephan
    Department of Urology, Charite Universitatsmedizin Berlin, CCM, Germany
    BJU Int 99:1427-31. 2007
    ..To show the effect of different results for total prostate specific antigen (tPSA) and percentage free/total PSA (%fPSA) obtained with different assays for differentiating between benign and malignant prostate diseases...
  82. ncbi request reprint Clinical value of vesical leukoplakia and evaluation of the neoplastic risk by mutation analyses of the tumor suppressor gene TP53
    Andrea Staack
    Department of Urology, University Hospital Charite, Humboldt University Berlin, Berlin, Germany
    Int J Urol 13:1092-7. 2006
    ..Leukoplakia has been found to be precancerous in organs covered with squamous epithelium. The present study was conducted to determine whether leukoplakia described in the female bladder is also a premalignant lesion...
  83. doi request reprint Quantitative determination of estrogen receptor, progesterone receptor, and HER2 mRNA in formalin-fixed paraffin-embedded tissue--a new option for predictive biomarker assessment in breast cancer
    Berit Maria Müller
    Institute of Pathology, Charite Hospital, Campus Mitte, Berlin, Germany
    Diagn Mol Pathol 20:1-10. 2011
    ..For the assessment of ESR1, PGR, and HER2 the results are comparable to the current gold-standard...
  84. ncbi request reprint Influence of intraperitoneal application of taurolidine/heparin on expression of adhesion molecules and colon cancer in rats undergoing laparoscopy
    Eva Bobrich
    Department of General, Visceral, Vascular and Thoracic Surgery, Universitaetsmedizin Berlin, Medical Faculty Charité, Humboldt University, Schumannstr, Berlin, Germany
    J Surg Res 137:75-82. 2007
    ..It might be that the anti-adherent activities of these agents are responsible for this effect. In this study we investigated the adhesion molecules E-cadherin, beta1-integrin, and CD44...
  85. ncbi request reprint Differential expression of the human kallikrein gene 14 (KLK14) in normal and cancerous prostatic tissues
    George M Yousef
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Canada
    Prostate 56:287-92. 2003
    ..Since KLK14 was found to be regulated by steroid hormones in prostate cancer cell lines, we hypothesized that it will be differentially expressed in prostate cancer tissues compared to their normal counterparts...
  86. ncbi request reprint mRNA expression profile of matrix metalloproteinases and their tissue inhibitors in malignant and non-malignant prostatic tissue
    Ralf Lichtinghagen
    Department of Clinical Chemistry, University Medical School, Hannover, Germany
    Anticancer Res 23:2617-24. 2003
    ..Increased expression of matrix metalloproteinases (MMPs) was found in various carcinomas. The aim of this study was to present a comprehensive mRNA expression profile of MMPs in benign and malignant prostatic tissue...
  87. ncbi request reprint Increased mRNA expression of ADAMs in renal cell carcinoma and their association with clinical outcome
    Andreas Roemer
    Department of Urology, University Hospital Charite, Humboldt University, Schumannstrasse 20 21, D 10098 Berlin, Germany
    Oncol Rep 11:529-36. 2004
    ..Our results indicate a potential role for ADAMs in RCC and that the overexpression might be a useful predictive tool...
  88. ncbi request reprint WIF1, a component of the Wnt pathway, is down-regulated in prostate, breast, lung, and bladder cancer
    Christoph Wissmann
    metaGen Pharmaceuticals GmbH, Oudenarder Strasse 16, 13347 Berlin, Germany
    J Pathol 201:204-12. 2003
    ..However, down-regulation of WIF1 correlated with higher tumour stage in urinary bladder tumours (pTa versus pT1-pT4; p = 0.038)...
  89. ncbi request reprint ITIH5, a novel member of the inter-alpha-trypsin inhibitor heavy chain family is downregulated in breast cancer
    Marina Himmelfarb
    metaGen Pharmaceuticals GmbH, Oudenarder Str 16, 13347 Berlin, Germany
    Cancer Lett 204:69-77. 2004
    ..ITIH5 mRNA was neither detectable in cancerous nor benign breast cell lines. We propose that loss of ITIH5 expression may be involved in breast cancer development...
  90. ncbi request reprint Gene expression profiles of microdissected pancreatic ductal adenocarcinoma
    Robert Grutzmann
    Department of Visceral, Thoracic and Vascular Surgery, University Hospital Carl Gustav Carus, Technical University of Dresden, Germany
    Virchows Arch 443:508-17. 2003
    ..In conclusion, using microarray technology we were able to identify a set of genes whose aberrant expression was associated with PDAC and may be used to target the disease...
  91. ncbi request reprint Diagnostic validity of macrophage migration inhibitory factor in serum of patients with prostate cancer: a re-evaluation
    Anja Michael
    Department of Urology, University Hospital Charite, Humboldt University, Schumann Strasse 20 21, D 10098 Berlin, Germany
    Prostate 62:34-9. 2005
    ..Recent studies suggest that macrophage migration inhibitory factor (MIF) in serum is of prognostic significance for prostate cancer. The aim of this study was to re-evaluate this hypothesis...
  92. ncbi request reprint Decreased RECK expression indicating proteolytic imbalance in prostate cancer is associated with higher tumor aggressiveness and risk of prostate-specific antigen relapse after radical prostatectomy
    Anja Rabien
    Department of Urology, Charite University Medicine, Humboldt University, Schumannstrasse 20 21, D 10098 Berlin, Germany
    Eur Urol 51:1259-66. 2007
    ..To evaluate its potential role for prostate carcinoma, we investigated RECK expression in prostate cancer (pCA) samples...
  93. ncbi request reprint Discovery and validation of 3 novel DNA methylation markers of prostate cancer prognosis
    Susan Cottrell
    Epigenomics, Inc, Seattle, Washington, USA
    J Urol 177:1753-8. 2007
    ..About 15% of men experience prostate specific antigen recurrence after radical prostatectomy. A DNA methylation based molecular test could provide important information to predict which patients are most likely to experience recurrence...
  94. ncbi request reprint Elevated plasma osteopontin as marker for distant metastases and poor survival in patients with renal cell carcinoma
    Azizbek Ramankulov
    Department of Urology, University Hospital Charite, Charite University Medicine Berlin, Campus Charite Mitte, Schumannstrasse 20 21, 10098 Berlin, Germany
    J Cancer Res Clin Oncol 133:643-52. 2007
    ..To evaluate diagnostic and prognostic significance of plasma osteopontin (OPN) in patients with renal cell carcinoma (RCC)...
  95. ncbi request reprint Malignant ascites-derived exosomes of ovarian carcinoma patients contain CD24 and EpCAM
    Steffen Runz
    Tumor Immunology Programme D010, German Cancer Research Center, Im Neuenheimer Feld 580, D 69120 Heidelberg, Germany
    Gynecol Oncol 107:563-71. 2007
    ..Given the emerging role of exosomes in tumor progression, we investigated whether cytoplasmic CD24 expression is correlated with the secretion of CD24 in exosomes...
  96. doi request reprint Multicenter study using paraffin-embedded tumor tissue testing PITX2 DNA methylation as a marker for outcome prediction in tamoxifen-treated, node-negative breast cancer patients
    Nadia Harbeck
    Department of Obstetrics and Gynecology and Pathology, Technical University of Munich, Munich, Germany
    J Clin Oncol 26:5036-42. 2008
    ....