R Kreutz

Summary

Affiliation: Humboldt University
Country: Germany

Publications

  1. ncbi request reprint A clinical and pharmacologic assessment of once-daily versus twice-daily dosing for rivaroxaban
    Reinhold Kreutz
    Institut fur Klinische Pharmakologie und Toxikologie, Charite Universitatsmedizin, Chariteplatz 1, 10117, Berlin, Germany
    J Thromb Thrombolysis 38:137-49. 2014
  2. ncbi request reprint Pharmacokinetics and pharmacodynamics of rivaroxaban--an oral, direct factor Xa inhibitor
    Reinhold Kreutz
    Department of Clinical Pharmacology and Toxicology, Charite, Universitatsmedizin Berlin, Chariteplatz 1, 10117 Berlin, Germany
    Curr Clin Pharmacol 9:75-83. 2014
  3. doi request reprint Pharmacodynamic and pharmacokinetic basics of rivaroxaban
    Reinhold Kreutz
    Department of Clinical Pharmacology and Toxicology, Charite Universitatsmedizin, Chariteplatz 1, Berlin, Germany
    Fundam Clin Pharmacol 26:27-32. 2012
  4. pmc Role of the H1 haplotype of microtubule-associated protein tau (MAPT) gene in Greek patients with Parkinson's disease
    Nikolaos Refenes
    School of Pharmacy, Department of Pharmaceutical Technology, National and Kapodistrian University of Athens, Athens, Greece
    BMC Neurol 9:26. 2009
  5. ncbi request reprint Pharmacokinetics of olmesartan medoxomil plus hydrochlorothiazide combination in healthy subjects
    Reinhold Kreutz
    Department of Clinical Pharmacology and Toxicology, Campus Benjamin Franklin, Charite Universitatsmedizin Berlin, Berlin, Germany
    Clin Drug Investig 26:29-34. 2006
  6. ncbi request reprint Induction of C1q expression in glomerular endothelium in a rat model with arterial hypertension and albuminuria
    Reinhold Kreutz
    Institute of Clinical Pharmacology, Charite Universitatsmedizin Berlin, Germany
    J Hypertens 25:2308-16. 2007
  7. doi request reprint CYP3A5 genotype is associated with longer patient survival after kidney transplantation and long-term treatment with cyclosporine
    R Kreutz
    Department of Clinical Pharmacology, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany
    Pharmacogenomics J 8:416-22. 2008
  8. doi request reprint [Special features of pharmacotherapy in older hypertensive subjects]
    R Kreutz
    Institut fur Klinische Pharmakologie und Toxikologie, Charite Universitatsmedizin Berlin, Campus Mitte, Chariteplatz 1, Berlin, Germany
    Internist (Berl) 50:442-54. 2009
  9. ncbi request reprint The role of the cytochrome P450 3A5 enzyme for blood pressure regulation in the general Caucasian population
    Reinhold Kreutz
    Department of Clinical Pharmacology, Campus Benjamin Franklin, Charite Universitatsmedizin Berlin, Germany
    Pharmacogenet Genomics 15:831-7. 2005
  10. pmc Olmesartan/amlodipine: a review of its use in the management of hypertension
    R Kreutz
    Institute of Clinical Pharmacology and Toxicology, Charite, Universtitätsmedizin Berlin, Germany
    Vasc Health Risk Manag 7:183-92. 2011

Detail Information

Publications78

  1. ncbi request reprint A clinical and pharmacologic assessment of once-daily versus twice-daily dosing for rivaroxaban
    Reinhold Kreutz
    Institut fur Klinische Pharmakologie und Toxikologie, Charite Universitatsmedizin, Chariteplatz 1, 10117, Berlin, Germany
    J Thromb Thrombolysis 38:137-49. 2014
    ..g. elimination half-life, obtained during pre-clinical and early phase I clinical studies but rather should be ascertained empirically in phase II and III clinical trials. ..
  2. ncbi request reprint Pharmacokinetics and pharmacodynamics of rivaroxaban--an oral, direct factor Xa inhibitor
    Reinhold Kreutz
    Department of Clinical Pharmacology and Toxicology, Charite, Universitatsmedizin Berlin, Chariteplatz 1, 10117 Berlin, Germany
    Curr Clin Pharmacol 9:75-83. 2014
    ....
  3. doi request reprint Pharmacodynamic and pharmacokinetic basics of rivaroxaban
    Reinhold Kreutz
    Department of Clinical Pharmacology and Toxicology, Charite Universitatsmedizin, Chariteplatz 1, Berlin, Germany
    Fundam Clin Pharmacol 26:27-32. 2012
    ....
  4. pmc Role of the H1 haplotype of microtubule-associated protein tau (MAPT) gene in Greek patients with Parkinson's disease
    Nikolaos Refenes
    School of Pharmacy, Department of Pharmaceutical Technology, National and Kapodistrian University of Athens, Athens, Greece
    BMC Neurol 9:26. 2009
    ..Therefore, we set out to determine whether the H1 haplotype and additional single nucleotide polymorphisms (SNPs) included in H1 are associated with PD in a sample of Greek patients...
  5. ncbi request reprint Pharmacokinetics of olmesartan medoxomil plus hydrochlorothiazide combination in healthy subjects
    Reinhold Kreutz
    Department of Clinical Pharmacology and Toxicology, Campus Benjamin Franklin, Charite Universitatsmedizin Berlin, Berlin, Germany
    Clin Drug Investig 26:29-34. 2006
    ..This trial investigated the possibility of pharmacokinetic interactions between the AT1 receptor antagonist olmesartan medoxomil and the thiazide diuretic hydrochlorothiazide in healthy subjects...
  6. ncbi request reprint Induction of C1q expression in glomerular endothelium in a rat model with arterial hypertension and albuminuria
    Reinhold Kreutz
    Institute of Clinical Pharmacology, Charite Universitatsmedizin Berlin, Germany
    J Hypertens 25:2308-16. 2007
    ..We set out to identify candidate genes for increased UAE by glomerular transcriptome analysis in the Munich Wistar Frömter (MWF) genetic rat model with spontaneous hypertension and albuminuria...
  7. doi request reprint CYP3A5 genotype is associated with longer patient survival after kidney transplantation and long-term treatment with cyclosporine
    R Kreutz
    Department of Clinical Pharmacology, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany
    Pharmacogenomics J 8:416-22. 2008
    ..Further, haplotype analysis at the CYP3A5 locus confirmed that CYP3A5*1 might indeed be responsible for this survival benefit...
  8. doi request reprint [Special features of pharmacotherapy in older hypertensive subjects]
    R Kreutz
    Institut fur Klinische Pharmakologie und Toxikologie, Charite Universitatsmedizin Berlin, Campus Mitte, Chariteplatz 1, Berlin, Germany
    Internist (Berl) 50:442-54. 2009
    ..Taking into account individual risk factors for unwanted events and avoidance of drug interactions during polypharmacotherapy are important aspects in differential therapy with antihypertensive agents in the elderly...
  9. ncbi request reprint The role of the cytochrome P450 3A5 enzyme for blood pressure regulation in the general Caucasian population
    Reinhold Kreutz
    Department of Clinical Pharmacology, Campus Benjamin Franklin, Charite Universitatsmedizin Berlin, Germany
    Pharmacogenet Genomics 15:831-7. 2005
    ..Its role in hypertensive disease and potential gender differences should be investigated in further studies...
  10. pmc Olmesartan/amlodipine: a review of its use in the management of hypertension
    R Kreutz
    Institute of Clinical Pharmacology and Toxicology, Charite, Universtitätsmedizin Berlin, Germany
    Vasc Health Risk Manag 7:183-92. 2011
    ..Olmesartan/amlodipine was generally well tolerated over the short- and long-term, with a lower frequency of peripheral edema with olmesartan/amlodipine 40/10 mg than with amlodipine 10 mg monotherapy...
  11. ncbi request reprint Rat chromosome 19 transfer from SHR ameliorates hypertension, salt-sensitivity, cardiovascular and renal organ damage in salt-sensitive Dahl rats
    Norbert Wendt
    Institut fur Klinische Pharmakologie und Toxikologie, Charite Universitatsmedizin Berlin, Berlin, Germany
    J Hypertens 25:95-102. 2007
    ..In previous linkage studies, we identified quantitative trait loci on rat chromosome 19 (RNO19) linked to the SHR allele suggesting a protective effect against salt-induced hypertensive organ damage in SS...
  12. ncbi request reprint Renal endothelin ET(A)/ET(B) receptor imbalance differentiates salt-sensitive from salt-resistant spontaneous hypertension
    L Rothermund
    , Benjamin Franklin Hospital, , Berlin, Germany
    Hypertension 37:275-80. 2001
    ..05). Thus, activation of the renal ET system together with an increased ET(A)/ET(B) receptor ratio may contribute to the development and progression of SS-SH...
  13. doi request reprint Deficits in pain treatment in nursing homes in Germany: a cross-sectional study
    M Kölzsch
    Institute of Clinical Pharmacology and Toxicology, Charite Universitatsmedizin Berlin, D 10117, Berlin, Germany
    Eur J Pain 16:439-46. 2012
    ..Current knowledge about the quality and appropriateness of pharmacological pain treatment in nursing home residents (NHR), particularly in NHR with moderate to severe cognitive impairment, is poor...
  14. doi request reprint Antipsychotic drugs predominate in pharmacotherapy of nursing home residents with dementia
    M Huber
    Institute of Clinical Pharmacology and Toxicology, Charite Universitatsmedizin Berlin, Berlin, Germany
    Pharmacopsychiatry 45:182-8. 2012
    ..Data of a German health insurance company were retrospectively analyzed for the year 2008...
  15. ncbi request reprint Genetic linkage of albuminuria and renal injury in Dahl salt-sensitive rats on a high-salt diet: comparison with spontaneously hypertensive rats
    Anja Kristin Siegel
    Institut fur Klinische Pharmakologie und Toxikologie, Campus Benjamin Franklin, Charite Universitatsmedizin Berlin, Berlin, Germany
    Physiol Genomics 18:218-25. 2004
    ..Our data suggest that the SHR genetic background confers greater susceptibility for the development of microangiopathy and tubulointerstitial injury in salt-sensitive hypertension than the SS background...
  16. ncbi request reprint Development of overt proteinuria in the Munich Wistar Frömter rat is suppressed by replacement of chromosome 6 in a consomic rat strain
    Angela Schulz
    Institut fur Klinische Pharmakologie und Toxikologie, Campus Benjamin Franklin, Charite Universitatsmedizin Berlin, Berlin, Germany
    J Am Soc Nephrol 18:113-21. 2007
    ..Therefore, although albuminuria in MWF is determined by a complex interplay of several QTL, our data demonstrate that genetic exchange of one locus on RNO6 leads to marked suppression of early-onset albuminuria and renal damage in MWF...
  17. ncbi request reprint Protective effect of female gender on the development of albuminuria in a polygenetic rat model is enhanced further by replacement of a major autosomal QTL
    Angela Schulz
    Institut fur Klinische Pharmakologie und Toxikologie, Charité Centrum für Thearapieforschung, Charite Universitatsmedizin Berlin, Berlin, Germany
    Clin Sci (Lond) 114:305-11. 2008
    ..Thus, taken together with previous studies in males, we show that RNO6 protects against the increase in albuminuria with age in both female and male MWF rats...
  18. ncbi request reprint Nephroprotective effects of the endothelin ET(A) receptor antagonist darusentan in salt-sensitive genetic hypertension
    Lars Rothermund
    Institut fur Klinische Pharmakologie und Toxikologie, Benjamin Franklin Hospital, Freie Universitat Berlin, Berlin, Germany
    Eur J Pharmacol 468:209-16. 2003
    ..05, respectively). This was either significantly reduced or normalized by darusentan (P<0.05, respectively). Thus, darusentan confers a significant renal protection in the Sabra model of salt-sensitive hypertension...
  19. ncbi request reprint Effect of high NaCl diet on spontaneous hypertension in a genetic rat model with reduced nephron number
    R Kreutz
    Department of Clinical Pharmacology and Toxicology, Benjamin Franklin Hospital, Freie Universitat Berlin, Germany
    J Hypertens 18:777-82. 2000
    ..MWF rats develop spontaneous hypertension and increased urinary albumin excretion (UAE). We addressed the question whether the inherited defect in this model leads to salt-sensitive hypertension...
  20. doi request reprint A twofold genetic increase of ACE expression has no effect on the development of spontaneous hypertension
    Ibrahim Nassar
    Institute of Clinical Pharmacology and Toxicology, Charité Centrum für Thearapieforschung, Charite Universitatsmedizin Berlin, Berlin, Germany
    Am J Hypertens 21:200-5. 2008
    ..e., the Ace allele of the normotensive Wistar-Kyoto (WKY) rat, in the hypertensive background of stroke-prone spontaneously hypertensive (SHRSP) rats...
  21. doi request reprint [Quality and appropriateness of pain medication. Instrument for estimation in nursing home residents]
    M Kölzsch
    Institut fur Klinische Pharmakologie und Toxikologie, Charite Universitatsmedizin Berlin, Chariteplatz 1, 10117, Berlin, Deutschland
    Schmerz 27:497-505. 2013
    ..This tool can be used to identify potential problems with the pharmacological treatment of pain...
  22. doi request reprint [Prescribing of antihypertensive drugs to elderly residents of nursing homes in Germany]
    M Kölzsch
    Institut fur Klinische Pharmakologie und Toxikologie, Charite Universitatsmedizin Berlin
    Dtsch Med Wochenschr 135:2400-5. 2010
    ..To analyse and evaluate the use of antihypertensive medication in elderly patients of nursing homes in Germany...
  23. doi request reprint [Antihypertensive drug treatment and renal function in geriatric emergency patients]
    J Bolbrinker
    Institut fur Klinische Pharmakologie und Toxikologie, Charite Universitatsmedizin Berlin, Campus Mitte
    Dtsch Med Wochenschr 134:802-6. 2009
    ..The aim of this study was to assess drug prescriptions and renal function in a cohort of geriatric emergency patients with a focus on antihypertensive drug treatment...
  24. doi request reprint Pharmacokinetics and safety of olmesartan medoxomil in combination with either amlodipine or atenolol compared to respective monotherapies in healthy subjects
    Juliane Bolbrinker
    Institute of Clinical Pharmacology and Toxicology, CharitéCentrum für Therapieforschung, Charite Universitatsmedizin Berlin, Berlin, Germany
    Fundam Clin Pharmacol 23:767-74. 2009
    ..5 h for each group in each study. Bioequivalence was established for all pharmacokinetic parameters. Lack of significant pharmacokinetic interactions between olmesartan and amlodipine or atenolol provides a basis for combination therapy...
  25. ncbi request reprint Pharmacokinetics and safety of olmesartan medoxomil in combination with glibenclamide in healthy volunteers
    Matthias Huber
    Department of Clinical Pharmacology and Toxicology, Campus Benjamin Franklin, Charite Universitatsmedizin Berlin, Berlin, Germany
    Clin Exp Hypertens 28:631-43. 2006
    ..To investigate the pharmacokinetic interactions, safety, and tolerability of the combination of olmesartan medoxomil with glibenclamide...
  26. ncbi request reprint Renal damage is not improved by blockade of endothelin receptors in primary renin-dependent hypertension
    Lars Rothermund
    Institut für Klinische Pharmakologie und Toxikologie and Medizinische Klinik IV Nephrologie, Campus Benjamin Franklin, Charite Universitatsmedizin Berlin, Freie Universitat Berlin, Germany
    J Hypertens 21:2389-97. 2003
    ..We tested the nephroprotective potential of selective endothelin A receptor (ETA) and non-selective ETA and endothelin B (ETA/B) receptor blockade in the TGR(mRen2)27 transgenic rat model with renin-dependent hypertension (Ren2)...
  27. ncbi request reprint A major gene locus links early onset albuminuria with renal interstitial fibrosis in the MWF rat with polygenetic albuminuria
    Angela Schulz
    Institute of Clinical Pharmacology and Toxicology and Department of Nephrology, Campus Benjamin Franklin, Charite Universitatsmedizin Berlin, Berlin, Germany
    J Am Soc Nephrol 14:3081-9. 2003
    ..This study demonstrates the power of genetic linkage analysis for the dissection of physiologic pathways involved in renal disease progression...
  28. doi request reprint [Interdisciplinary guidance for pain management in nursing home residents]
    I Wulff
    Institut für Medizinische Soziologie, Charite Universitatsmedizin Berlin, Luisenstr 13, 10117, Berlin, Deutschland
    Z Gerontol Geriatr 45:505-44. 2012
    ..Besides, drug interactions need to be considered. After all, education of NHR and involvement of their relatives in pain management foster successful management and treatment of pain...
  29. ncbi request reprint Congenic substitution mapping excludes Sa as a candidate gene locus for a blood pressure quantitative trait locus on rat chromosome 1
    N Hubner
    Max Delbruck Center for Molecular Medicine, and the Department of Clinical Pharmacology, Benjamin Franklin Medical Center, Freie Universitat Berlin, Berlin, Germany
    Hypertension 34:643-8. 1999
    ..4-p15.3. This region excludes the Sa as a blood pressure-elevating candidate gene locus on the basis of congenic substitution mapping approaches...
  30. pmc Decreased cardiac SERCA2 expression, SR Ca uptake, and contractile function in hypothyroidism are attenuated in SERCA2 overexpressing transgenic rats
    Roland Vetter
    Institute of Clinical Pharmacology and Toxicology, Charite Universitatsmedizin Berlin, Berlin
    Am J Physiol Heart Circ Physiol 300:H943-50. 2011
    ..However, SR Ca(2+) uptake and in vivo heart function were only partially rescued...
  31. ncbi request reprint Genetic locus on MWF rat chromosome 6 affects kidney damage in response to L-NAME treatment in spontaneously hypertensive rats
    Angela Schulz
    Department of Clinical Pharmacology and Toxicology, Charité Centrum für Therapieforschung, Charite Universitatsmedizin Berlin, Berlin, Germany
    Physiol Genomics 42:126-33. 2010
    ..Moreover, our data indicate that genes on RNO6 contribute to the development of L-NAME-induced renal damage in the SHR strain...
  32. ncbi request reprint Endothelin-A receptor blockade prevents left ventricular hypertrophy and dysfunction in salt-sensitive experimental hypertension
    Lars Rothermund
    Institut fur Klinische Pharmakologie, Benjamin Franklin Hospital, Freie Universitat Berlin, Berlin, Germany
    Circulation 106:2305-8. 2002
    ....
  33. doi request reprint Genetic analysis of salt-sensitive hypertension in Dahl rats reveals a link between cardiac fibrosis and high cholesterol
    Norbert Wendt
    Department of Clinical Pharmacology and Toxicology CBF CCM, CharitéCentrum für Therapieforschung, Charite Universitatsmedizin Berlin, Berlin, Germany
    Cardiovasc Res 81:618-26. 2009
    ..To this end we utilized a consomic SS-19(SHR) rat strain in which RNO19 was transferred from spontaneously hypertensive rats (SHR) into the susceptible background of SS...
  34. ncbi request reprint Quality of life in hypertension management using olmesartan in primary care
    Andre C Schmidt
    Charite Universitatsmedizin Berlin, Department of Clinical Pharmacology and Toxicology, CharitéCentrum für Therapieforschung, Chariteplatz 1, D 10117 Berlin, Germany
    Expert Opin Pharmacother 9:1641-53. 2008
    ..As this is the prerequisite for cardiovascular risk reduction, QoL was investigated using highly tolerable drugs (such as olmesartan)...
  35. doi request reprint Nephron deficit is not required for progressive proteinuria development in the Munich Wistar Frömter rat
    Angela Schulz
    Department of Clinical Pharmacology and Toxicology, CharitéCentrum für Therapieforschung, Charite Universitatsmedizin Berlin, Berlin, Germany
    Physiol Genomics 35:30-5. 2008
    ..The locus on chromosome 8 appears of interest, because its exchange between MWF and SHR protects against the development of albuminuria in MWF-8(SHR) animals despite their inherited nephron deficit and higher systolic blood pressure...
  36. ncbi request reprint Pharmacogenetics of antihypertensive drug response
    Reinhold Kreutz
    Department of Clinical Pharmacology, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12203 Berlin, Germany
    Curr Hypertens Rep 6:15-20. 2004
    ..In this article, some important, recent research work and progress on the pharmacogenetics of antihypertensive drug responses are reviewed and evaluated...
  37. ncbi request reprint Genetic low nephron number hypertension is associated with dysregulation of the hepatic and renal insulin-like growth factor system during nephrogenesis
    Lars Rothermund
    Medizinische Klinik IV, Endokrinologie und Nephrologie, Charite Universitatsmedizin Berlin, Berlin, Germany
    J Hypertens 24:1857-64. 2006
    ..We tested the hypothesis that low nephron number is already present during fetal development, and the expression pattern of important molecules of the IGF system is altered in MWF rat during the critical period of kidney development...
  38. ncbi request reprint Early onset of chondroitin sulfate and osteopontin expression in angiotensin II-dependent left ventricular hypertrophy
    Lars Rothermund
    Institut fur Klinische Pharmakologie und Toxikologie, Berlin, Germany
    Am J Hypertens 15:644-52. 2002
    ..The objective of this study was to analyze extracellular matrix protein (ECMP) expression in Ang II-dependent left ventricular (LV) hypertrophy (LVH), LV dysfunction, and to investigate right ventricular changes...
  39. ncbi request reprint Expression and response to angiotensin-converting enzyme inhibition of matrix metalloproteinases 2 and 9 in renal glomerular damage in young transgenic rats with renin-dependent hypertension
    Juliane Bolbrinker
    Department of Clinical Pharmacology, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, Germany
    J Pharmacol Exp Ther 316:8-16. 2006
    ..Interestingly, down-regulation of MMP-9 mRNA, protein, and activity was not affected by ramipril, indicating that the protective effect of this compound is not attributable to restoration of MMP-9 in the glomerulus...
  40. ncbi request reprint [Potentially inappropriate medication for the elderly: adaptation and evaluation of a French consensus list]
    Marita Kölzsch
    Institut fur Klinische Pharmakologie und Toxikologie, Charite Universitatsmedizin Berlin
    Med Monatsschr Pharm 33:295-302. 2010
    ..Appropriate pharmacotherapy is one of the most important topics due to demographic development in many industrialised countries. The purpose of our work was to evaluate and adjust a French consensus list for Germany...
  41. doi request reprint Safety and efficacy of olmesartan: an observational pooled-analysis of 156,682 hypertensive patients
    Jurgen Scholze
    Centrum für Innere Medizin, Direktor Medizinische Poliklinik, Campus Mitte, Luisenstr 11 13, 10117 Berlin, Germany
    Expert Opin Drug Saf 10:185-96. 2011
    ..Angiotensin type 1 receptor blockers are recommended for first-line antihypertensive treatment...
  42. doi request reprint Microangiopathy and visual deficits characterize the retinopathy of a spontaneously hypertensive rat model with type 2 diabetes and metabolic syndrome
    Matthias Huber
    Institut fur Klinische Pharmakologie und Toxikologie, Charité Centrum für Therapieforschung, Charite Universitatsmedizin Berlin, Berlin, Germany
    Hypertens Res 34:103-12. 2011
    ..Thus, this model represents a valuable experimental tool to obtain further insights into the mechanisms of retinopathy in the context of obesity, type 2 diabetes and metabolic syndrome...
  43. doi request reprint Role of CYP2C9 genetic variants for salt sensitivity and the regulation of the renin-angiotensin-aldosterone system in normotensive men
    Juliane Bolbrinker
    Institute of Clinical Pharmacology and Toxicology, Campus Charite Mitte, Charite Universitatsmedizin Berlin, Berlin, Germany
    J Hypertens 29:56-61. 2011
    ..We tested the relevance of CYP2C9 genotypes for regulation of plasma renin activity (PRA), plasma aldosterone concentrations and blood pressure (BP) in response to changes in salt intake in normotensive individuals...
  44. ncbi request reprint [Therapy of hypertension]
    R Kreutz
    Charite Universitatsmedizin Berlin, Hindenburgdamm 30, 12200 Berlin, Germany
    Clin Res Cardiol 95:VI34-40. 2006
    ..Overall, approximately two-thirds of patients require treatment with at least two drugs to achieve target blood pressure values...
  45. doi request reprint [Use of health insurance data to analyse pain management practices in the nursing-home setting]
    K Kopke
    Charite Universitatsmedizin Berlin, Institut für Medizinische Soziologie, Luisenstraße 13, Berlin
    Gesundheitswesen 73:e119-25. 2011
    ..The routine method for this analysis proved to be practicable and reliable. Data quality is deemed sufficient so that the main study will proceed to include a longer period of time and additional data...
  46. ncbi request reprint Differential development of early hypertension in heterozygous transgenic TGR(mREN2)27 rats
    R Kreutz
    Department of Endocrinology and Nephrology, University Hospital Benjamin Franklin, Freie Universitat, Berlin, Germany
    Clin Exp Hypertens 20:273-82. 1998
    ..Moreover, development of early hypertension in young heterozygous TGR(mREN2)27 is associated with higher plasma prorenin levels...
  47. doi request reprint Short-term treatment with a beta-blocker with vasodilative capacities improves intrarenal endothelial function in experimental renal failure
    Simone Gschwend
    Institut fur Klinische Pharmakologie und Toxikologie, Charité Centrum für Therapieforschung, Germany
    Life Sci 85:431-7. 2009
    ....
  48. ncbi request reprint Mechanisms of apoptosis after ischemia and reperfusion: role of the renin-angiotensin system
    P Kossmehl
    Institute of Clinical Pharmacology and Toxicology, Charite University Medicine Berlin, Benjamin Franklin Campus, Berlin, Germany
    Apoptosis 11:347-58. 2006
    ..We examined the influence of the renin-angiotensin system (RAS) on different regulators of apoptosis using an isolated hemoperfused working porcine heart model of acute ischemia (2 h), followed by reperfusion (4 h)...
  49. ncbi request reprint A polymorphism in the endothelin-A receptor gene predicts survival in patients with idiopathic dilated cardiomyopathy
    S Herrmann
    Institute of Clinical Pharmacology and Toxicology, Department of Clinical Pharmacology, Benjamin Franklin Medical Center, Freie Universitat Berlin, Germany
    Eur Heart J 22:1948-53. 2001
    ..We investigated whether genetic polymorphisms of the endothelin system might be associated with dilated cardiomyopathy-related cardiac phenotypes and differences in disease outcome...
  50. ncbi request reprint [Value of combination therapy in treatment of hypertension]
    Reinhold Kreutz
    Leiter Abteilung Klinische Pharmakologie, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Berlin
    Krankenpfl J 43:255. 2005
  51. ncbi request reprint The effect of variable CYP3A5 expression on cyclosporine dosing, blood pressure and long-term graft survival in renal transplant patients
    Reinhold Kreutz
    Abteilung Klinische Pharmakologie, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, Germany
    Pharmacogenetics 14:665-71. 2004
    ....
  52. ncbi request reprint Increased transient receptor potential channel TRPC3 expression in spontaneously hypertensive rats
    Daoyan Liu
    Medizinische Klinik IV, Charite Campus Benjamin Franklin, Berlin, Germany
    Am J Hypertens 18:1503-7. 2005
    ....
  53. ncbi request reprint Congenic rat strains are important tools for the genetic dissection of essential hypertension
    Reinhold Kreutz
    Department of Clinical Pharmacology, Benjamin Franklin Medical Center, Freie Universitat Berlin, Germany
    Semin Nephrol 22:135-47. 2002
    ..This will open the possibility for the development of new diagnostic and therapeutic means contributing to a better control of human essential hypertension...
  54. ncbi request reprint Monocytes from spontaneously hypertensive rats show increased store-operated and second messenger-operated calcium influx mediated by transient receptor potential canonical Type 3 channels
    Dao Yan Liu
    Medizinische Klinik IV, Nephrologie, Charite Campus Benjamin Franklin, Berlin, Germany
    Am J Hypertens 20:1111-8. 2007
    ....
  55. ncbi request reprint Impaired function of endothelial pressure-activated cation channel in salt-sensitive genetic hypertension
    R Kohler
    Department of Nephrology, Freie Universitat Berlin, Berlin, Germany
    J Am Soc Nephrol 12:1624-9. 2001
    ..The defective PAC function presumably leads to an impaired mechanosensitive Ca(2+) entry and might contribute to endothelial dysfunction and high BP in this type of salt-sensitive genetic hypertension...
  56. doi request reprint Tissue expression of TRPC3 and TRPC6 in hypertensive Munich Wistar Frömter rats showing proteinuria
    Ying Liu
    Medizinische Klinik Nephrologie, Charite Campus Benjamin Franklin, Berlin, Germany
    Am J Nephrol 31:36-44. 2010
    ..We investigated whether alterations of transient receptor potential canonical (TRPC) channel expression may be observed in tissues from Munich Wistar Frömter (MWF) rats showing proteinuria compared to control Wistar rats...
  57. doi request reprint Role of the angiotensin II type 2 receptor gene (+1675G/A) polymorphism on left ventricular hypertrophy and geometry in treated hypertensive patients
    Matthias Huber
    Institute of Clinical Pharmacology and Toxicology, Charité Centrum für Therapieforschung, Charite Universitatsmedizin Berlin, Berlin, Germany
    J Hypertens 28:1221-9. 2010
    ..We tested whether this polymorphism affects LVH and left ventricular geometry parameters in patients with essential hypertension and cardiovascular disease who are treated according to guidelines...
  58. ncbi request reprint Physiology of local renin-angiotensin systems
    Martin Paul
    Institute of Clinical Pharmacology and Toxicology, Campus Benjamin Franklin, Charite University Medicine Berlin, Berlin, Germany
    Physiol Rev 86:747-803. 2006
    ..Taken together, these findings may become increasingly important in the study of organ physiology but also for a fresh look at the implications of these findings for organ pathophysiology...
  59. ncbi request reprint Expression of vascular endothelial growth factor and receptor tyrosine kinases in cardiac ischemia/reperfusion injury
    Manfred Infanger
    Department of Trauma and Reconstructive Surgery, Charite Universitatsmedizin Berlin, Benjamin Franklin Campus, 12203, Berlin, Germany
    Cardiovasc Pathol 16:291-9. 2007
    ....
  60. ncbi request reprint Genetic dissection of increased urinary albumin excretion in the munich wistar frömter rat
    Angela Schulz
    Institut für Klinische Pharmakologie und Toxikologie and Medizinische Klinik IV Nephrologie, Universitätsklinikum Benjamin Franklin Hospital, Freie Universitat Berlin, Germany
    J Am Soc Nephrol 13:2706-14. 2002
    ..This study demonstrates the polygenetic recessive determination of increased UAE by a set of genes that are unlinked to BP...
  61. ncbi request reprint Early onset albuminuria in Dahl rats is a polygenetic trait that is independent from salt loading
    Ali Poyan Mehr
    Institute of Clinical Pharmacology and Toxicology, Universitätsklinikum Benjamin Franklin Hospital, Freie Universitat Berlin, Germany
    Physiol Genomics 14:209-16. 2003
    ..Thus early onset albuminuria in the SS rat is under polygenetic influence and independent from salt loading...
  62. pmc Selective loss of podoplanin protein expression accompanies proteinuria and precedes alterations in podocyte morphology in a spontaneous proteinuric rat model
    Klaas Koop
    Department of Pathology, Leiden University Medical Center, Building 1, L1 Q, PO Box 9600, 2300 RC Leiden, The Netherlands
    Am J Pathol 173:315-26. 2008
    ..Our study suggests that decreased expression of podoplanin plays a role in the decrease of glomerular permselectivity...
  63. ncbi request reprint No association of the CYP3A5*1 allele with blood pressure and left ventricular mass and geometry: the KORA/MONICA Augsburg echocardiographic substudy
    Wolfgang Lieb
    Medizinische Klinik 2, Universitatsklinikum Schleswig Holstein, Campus Lubeck, Lubeck, Germany
    Clin Sci (Lond) 111:365-72. 2006
    ..We conclude that CYP3A5*1 exhibits no significant effect on BP, LVM and LV geometry in the KORA/MONICA echocardiographic substudy...
  64. ncbi request reprint Cardiac fibrosis occurs early and involves endothelin and AT-1 receptors in hypertension due to endogenous angiotensin II
    Teresa M Seccia
    Department of Clinical Methodology and Clinical Surgical Technologies, University of Bari, Bari, Italy
    J Am Coll Cardiol 41:666-73. 2003
    ..We investigated if endothelin (ET)-1 and the renin-angiotensin-aldosterone system play a role in cardiac fibrosis...
  65. ncbi request reprint Profiling of the renal kinome: a novel tool to identify protein kinases involved in angiotensin II-dependent hypertensive renal damage
    Martin H de Borst
    Dept of Pathology, University of Groningen, University Medical Center Groningen, PO Box 30 001, 9700 RB Groningen, The Netherlands
    Am J Physiol Renal Physiol 293:F428-37. 2007
    ..Array-based profiling of tissue kinase activities in ANG II-mediated renal damage provides a powerful tool for identification of relevant kinase pathways in vivo and may lead to novel strategies for therapy...
  66. ncbi request reprint Congenic strains confirm the presence of salt-sensitivity QTLs on chromosome 1 in the Sabra rat model of hypertension
    Chana Yagil
    Laboratory for Molecular Medicine and Rat Genome Center, Faculty of Health Sciences, Ben Gurion University Barzilai Medical Center Campus, Ashkelon 78306, Israel
    Physiol Genomics 12:85-95. 2003
    ..The unexpected finding was that QTL SS1a contributes to the hypertensive response also in females. The data indicate the lack of a Y chromosomal effect or of parental imprinting...
  67. ncbi request reprint Low-dose lithium combined with captopril prevents stroke and improves survival in salt-loaded, stroke-prone spontaneously hypertensive rats
    Jihong Xu
    Institute of Pharmacology, University Hospital of Schleswig Holstein, Campus Kiel, Germany
    J Hypertens 23:2277-85. 2005
    ..In the present study, we investigated the effects of a low-dose combination treatment with lithium and captopril on survival and stroke prevention in salt-loaded, stroke-prone spontaneously hypertensive rats (SHRSP)...
  68. ncbi request reprint Interaction between blood pressure quantitative trait loci in rats in which trait variation at chromosome 1 is conditional upon a specific allele at chromosome 10
    Jan Monti
    Max Delbrück Center for Molecular Medicine MDC, Berlin Buch, Germany
    Hum Mol Genet 12:435-9. 2003
    ..05). The interaction accounted for 5 mmHg of blood pressure. Thus, the identification of epistasis is critical to the understanding of the quantitative nature of blood pressure genetics...
  69. ncbi request reprint Impaired coronary endothelial function in a rat model of spontaneous albuminuria
    Simone Gschwend
    Department of Clinical Pharmacology, Division of Nephrology, University of Groningen, Groningen, The Netherlands
    Kidney Int 62:181-91. 2002
    ..Our aim was to investigate if the MWF strain shows generalized endothelial dysfunction or endothelial dysfunction localized to the coronary vascular bed, and if so, determine which endothelial dilative mediators are involved...
  70. ncbi request reprint Genetic loci contribute to the progression of vascular and cardiac hypertrophy in salt-sensitive spontaneous hypertension
    Anja Kristin Siegel
    Benjamin Franklin Hospital, Freie Universitat Berlin, Germany
    Arterioscler Thromb Vasc Biol 23:1211-7. 2003
    ..We set out to identify quantitative trait loci (QTLs) contributing to the progression of salt-induced organ damage in hypertension by studying an F2 population derived from both strains...
  71. ncbi request reprint Genetic kininogen deficiency contributes to aortic aneurysm formation but not to atherosclerosis
    Elena Kaschina
    Center for Cardiovascular Research Institute of Pharmacology and Toxicology, Campus Charite Mitte, Charite University Medicine Berlin, 10115 Berlin, Germany
    Physiol Genomics 19:41-9. 2004
    ..These findings suggest that genetic kininogen deficiency renders vascular tissue prone to aneurysmatic but not to atherosclerotic lesions...
  72. ncbi request reprint Left-ventricular structure and function are influenced by angiotensinogen gene polymorphism (-20 A/C) in young male patients
    Christian Ott
    Department of Nephrology and Hypertension, University of Erlangen Nurnberg, Erlangen, Germany
    Am J Hypertens 20:974-80. 2007
    ..Therefore, we questioned whether left-ventricular (LV) structure and function are influenced by the -20 A/C variant of the angiotensinogen (AGT) gene in young normotensive or mildly hypertensive patients...
  73. ncbi request reprint Increase of fibronectin and osteopontin in porcine hearts following ischemia and reperfusion
    Peter Kossmehl
    Institute of Clinical Pharmacology and Toxicology, Benjamin Franklin Medical Center, Charite University Medical School, Garystr 5, 14195 Berlin, Germany
    J Mol Med (Berl) 83:626-37. 2005
    ..Moreover, OPN, fibronectin and TGF-beta1 protein and gene expression are elevated after ischemia and reperfusion in the ex vivo working hemoperfused porcine heart model...
  74. ncbi request reprint Role of the endothelin-1 gene locus for renal impairment in the general nondiabetic population
    Sara Joan Pinto-Sietsma
    Department of Internal Medicine, Division of Nephrology, Academic Hospital Groningen, University Groningen, Groningen, The Netherlands
    J Am Soc Nephrol 14:2596-602. 2003
    ....
  75. ncbi request reprint Modeled gravitational unloading induced downregulation of endothelin-1 in human endothelial cells
    Manfred Infanger
    Department of Trauma and Reconstructive Surgery, Charite University Medical School, Benjamin Franklin Medical Center, Center of Space Medicine, 12200 Berlin, Germany
    J Cell Biochem 101:1439-55. 2007
    ..The gene expression of endothelin-1 was suppressed under microg conditions at days 7 and 10. Alterations of the vascular endothelium together with a decreased release of endothelin-1 may entail post-flight health hazards for astronauts...
  76. ncbi request reprint High sodium intake modulates left ventricular mass in patients with G expression of +1675 G/A angiotensin II receptor type 2 gene
    Christian Ott
    Department of Nephrology and Hypertension, University of Erlangen Nuremberg, Nuremberg, Germany
    J Hypertens 25:1627-32. 2007
    ..Hypertension and LVH are often aggravated by salt intake. Our objective was to assess the relationship between AT2R gene variation and salt intake and their impact on left ventricular mass (LVM)...
  77. ncbi request reprint Matrix analysis for the dissection of interactions of G-protein beta3 subunit C825T genotype, allograft function, and posttransplant hypertension in kidney transplantation
    Joachim Beige
    Division of Endocrinology and Nephrology, Department of Internal Medicine, Universitatsklinikum Benjamin Franklin, Freie Universitaet Berlin, Germany
    Am J Kidney Dis 40:1319-24. 2002
    ..The authors, therefore, applied matrix analyses to account for interactions between genetic and environmental factors influencing kidney allograft function...
  78. ncbi request reprint The G-231A polymorphism in the endothelin-A receptor gene is associated with lower aortic pressure in patients with dilated cardiomyopathy
    Ralph Telgmann
    Leibniz Institute for Arteriosclerosis Research, Department of Molecular Genetics of Cardiovascular Disease, University of Muenster, Domagkstrasse 3, D 48149 Muenster, Germany
    Am J Hypertens 20:32-7. 2007
    ..The aim of this study was to determine whether polymorphisms in the ET(A) receptor gene might be associated with the severity of DCM...