Affiliation: Humboldt University
- Extensive alternative splicing of interleukin-7 in malignant hematopoietic cells: implication of distinct isoforms in modulating IL-7 activityA Korte
Department of Pediatric Oncology Hematology, Charité Universitäsklinikum, Humboldt University at Berlin, Germany
J Interferon Cytokine Res 19:495-503. 1999..Further studies are required to clarify the significance of the diverse IL-7 protein isoforms for the regulation of IL-7 function and the pathogenesis of leukemia...
- Expression analysis and characterization of alternatively spliced transcripts of human IL-7Ralpha chain encoding two truncated receptor proteins in relapsed childhood allA Korte
Department of Pediatric Oncology Hematology, Charite Medical Center, Campus Virchow, Germany
Cytokine 12:1597-608. 2000..Our results lead us to assume that splicing derived IL-7Ralpha isoforms play a potential role in modulating IL-7 signal transduction and might be important for the pathogenesis of leukaemia...
- Characterization of cytokine, growth factor receptor, costimulatory and adhesion molecule expression patterns of bone marrow blasts in relapsed childhood B cell precursor allC Kebelmann-Betzing
Department of Pediatric Oncology Hematology, Charite, Campus Virchow Medical Center, Humboldt University at Berlin, Germany christain
Cytokine 13:39-50. 2001..The secretion of IL-10 by leukaemic cells, and the absence or downregulation of conventional adhesion and costimulatory molecules might represent an effective mechanism of escape of immune surveillance in relapsed ALL...