Frederick Klauschen

Summary

Affiliation: Humboldt University
Country: Germany

Publications

  1. doi request reprint Histological tumor typing in the age of molecular profiling
    Frederick Klauschen
    Institute of Pathology, Charite Universitatsmedizin Berlin, Chariteplatz 1, 10117 Berlin, Germany Einstein Foundation Berlin, Germany Electronic address
    Pathol Res Pract 211:897-900. 2015
  2. doi request reprint Standardized Ki67 Diagnostics Using Automated Scoring--Clinical Validation in the GeparTrio Breast Cancer Study
    Frederick Klauschen
    Institute of Pathology, Charite University Hospital Berlin, Chariteplatz 1, Berlin, Germany
    Clin Cancer Res 21:3651-7. 2015
  3. doi request reprint [Mutational tumor profiles beyond organ and tissue specificity: implications for diagnostics and clinical study design]
    F Klauschen
    Institut fur Pathologie, Charite Universitatsmedizin Berlin, Chariteplatz 1, 10117, Berlin, Deutschland
    Pathologe 35:277-80. 2014
  4. doi request reprint High nuclear poly-(ADP-ribose)-polymerase expression is prognostic of improved survival in pancreatic cancer
    Frederick Klauschen
    Institute of Pathology, Charite University Medicine Berlin, Germany
    Histopathology 61:409-16. 2012
  5. pmc CognitionMaster: an object-based image analysis framework
    Stephan Wienert
    Institute of Pathology, Charite University Hospital Berlin, Chariteplatz 1, Berlin, 10117, Germany
    Diagn Pathol 8:34. 2013
  6. doi request reprint High extracellular matrix metalloproteinase inducer/CD147 expression is strongly and independently associated with poor prognosis in colorectal cancer
    Albrecht Stenzinger
    Institute of Pathology, University of Heidelberg, and National Center for Tumor Diseases, 69120 Heidelberg, Germany
    Hum Pathol 43:1471-81. 2012
  7. doi request reprint Comprehensive analysis of clinico-pathological data reveals heterogeneous relations between atherosclerosis and cancer
    Jan Budczies
    Institute of Pathology, Charite University Hospital, Berlin, Germany
    J Clin Pathol 67:482-90. 2014
  8. doi request reprint DNA index as a strong prognostic factor in patients with adenocarcinoma of the pancreatic head: results of a 5-year prospective study
    Carsten Kamphues
    Department of General, Visceral and Transplantation Surgery, Charite University Hospital, Berlin, Germany
    Pancreas 42:807-12. 2013
  9. pmc Detection and segmentation of cell nuclei in virtual microscopy images: a minimum-model approach
    Stephan Wienert
    Institute of Pathology, Charite University Hospital Berlin, 10117 Berlin, Germany
    Sci Rep 2:503. 2012
  10. doi request reprint DNA index is a strong predictive marker in intrahepatic cholangiocarcinoma: the results of a five-year prospective study
    Carsten Kamphues
    Department of General Visceral and Transplantation Surgery, Charite University Hospital, Berlin, Germany
    Surg Today 44:1336-42. 2014

Collaborators

Detail Information

Publications33

  1. doi request reprint Histological tumor typing in the age of molecular profiling
    Frederick Klauschen
    Institute of Pathology, Charite Universitatsmedizin Berlin, Chariteplatz 1, 10117 Berlin, Germany Einstein Foundation Berlin, Germany Electronic address
    Pathol Res Pract 211:897-900. 2015
    ..We discuss the implications of the observed complex mutational tumor profiles for targeted therapy selection and future trial design in precision oncology. ..
  2. doi request reprint Standardized Ki67 Diagnostics Using Automated Scoring--Clinical Validation in the GeparTrio Breast Cancer Study
    Frederick Klauschen
    Institute of Pathology, Charite University Hospital Berlin, Chariteplatz 1, Berlin, Germany
    Clin Cancer Res 21:3651-7. 2015
    ..Therefore, an accurate and standardized Ki67 scoring is pivotal both in routine diagnostics and larger multicenter studies...
  3. doi request reprint [Mutational tumor profiles beyond organ and tissue specificity: implications for diagnostics and clinical study design]
    F Klauschen
    Institut fur Pathologie, Charite Universitatsmedizin Berlin, Chariteplatz 1, 10117, Berlin, Deutschland
    Pathologe 35:277-80. 2014
    ....
  4. doi request reprint High nuclear poly-(ADP-ribose)-polymerase expression is prognostic of improved survival in pancreatic cancer
    Frederick Klauschen
    Institute of Pathology, Charite University Medicine Berlin, Germany
    Histopathology 61:409-16. 2012
    ..In the pancreas, PARP expression has so far only been studied in inflammatory conditions. Therefore, in this study, we investigated the relevance of PARP in pancreatic cancer...
  5. pmc CognitionMaster: an object-based image analysis framework
    Stephan Wienert
    Institute of Pathology, Charite University Hospital Berlin, Chariteplatz 1, Berlin, 10117, Germany
    Diagn Pathol 8:34. 2013
    ..However, most of the approaches rely on pixel-wise operations, a concept that has limitations when high-level object features and relationships between objects are studied and if user-interactivity on the object-level is desired...
  6. doi request reprint High extracellular matrix metalloproteinase inducer/CD147 expression is strongly and independently associated with poor prognosis in colorectal cancer
    Albrecht Stenzinger
    Institute of Pathology, University of Heidelberg, and National Center for Tumor Diseases, 69120 Heidelberg, Germany
    Hum Pathol 43:1471-81. 2012
    ....
  7. doi request reprint Comprehensive analysis of clinico-pathological data reveals heterogeneous relations between atherosclerosis and cancer
    Jan Budczies
    Institute of Pathology, Charite University Hospital, Berlin, Germany
    J Clin Pathol 67:482-90. 2014
    ..Therefore, we sought to investigate the relation between major cancer types and the grade of atherosclerosis in a recent well-powered autopsy cohort...
  8. doi request reprint DNA index as a strong prognostic factor in patients with adenocarcinoma of the pancreatic head: results of a 5-year prospective study
    Carsten Kamphues
    Department of General, Visceral and Transplantation Surgery, Charite University Hospital, Berlin, Germany
    Pancreas 42:807-12. 2013
    ..The aim of the present study was to prospectively assess the prognostic value of DNA index determined by image cytometry as an predictive factor in pancreatic head cancer...
  9. pmc Detection and segmentation of cell nuclei in virtual microscopy images: a minimum-model approach
    Stephan Wienert
    Institute of Pathology, Charite University Hospital Berlin, 10117 Berlin, Germany
    Sci Rep 2:503. 2012
    ..908; recall = 0.859; validation based on ∼8000 manually-labeled cells) of a broad spectrum of normal and disease-related morphological features without the requirement of prior training...
  10. doi request reprint DNA index is a strong predictive marker in intrahepatic cholangiocarcinoma: the results of a five-year prospective study
    Carsten Kamphues
    Department of General Visceral and Transplantation Surgery, Charite University Hospital, Berlin, Germany
    Surg Today 44:1336-42. 2014
    ..The aim of this study was to prospectively evaluate the prognostic potential of the DNA index in patients undergoing liver resection for IHC...
  11. pmc The landscape of metastatic progression patterns across major human cancers
    Jan Budczies
    Institute of Pathology, Charite University Hospital, Berlin, Germany German Cancer Research Center dkfz, Heidelberg, Germany German Consortium for Translational Cancer Research DKTK, Heidelberg, Germany
    Oncotarget 6:570-83. 2015
    ..The delineated landscape of metastatic progression patterns is a comprehensive data resource to both clinical and basic scientists which aids fostering new hypotheses for cancer research and cancer therapies. ..
  12. pmc High SIRT1 expression is a negative prognosticator in pancreatic ductal adenocarcinoma
    Albrecht Stenzinger
    Institute of Pathology, and National Center for Tumor Diseases NCT, University Hospital Heidelberg, Heidelberg, Germany
    BMC Cancer 13:450. 2013
    ..Since data on the role of Sirt1 in pancreatic ductal adenocarcinoma (PDAC) are sparse, we investigated the expression profile and prognostic significance of Sirt1 in vivo as well as cellular effects of Sirt1 inhibition in vitro...
  13. pmc Remodeling of central metabolism in invasive breast cancer compared to normal breast tissue - a GC-TOFMS based metabolomics study
    Jan Budczies
    Institute of Pathology, Charite University Hospital, 10117 Berlin, Germany
    BMC Genomics 13:334. 2012
    ..However, the metabolic changes between invasive carcinoma and normal breast tissues were not investigated in a large cohort of breast cancer samples so far...
  14. doi request reprint Reversion-inducing cysteine-rich protein with Kazal motif (RECK) expression: an independent prognostic marker of survival in colorectal cancer
    Albrecht Stenzinger
    Institute of Pathology, University of Heidelberg, and National Center of Tumor Diseases, Im Neuenheimer Feld 220 221, 69120 Heidelberg, Germany
    Hum Pathol 43:1314-21. 2012
    ..18) and that decreased RECK expression was an independent prognostic factor of poor survival, with a mean survival of 70 months in RECK-negative (146 cases) versus 97 months in RECK-positive patients (137 cases) (log-rank test, P = .002)...
  15. pmc Cutoff Finder: a comprehensive and straightforward Web application enabling rapid biomarker cutoff optimization
    Jan Budczies
    Institut fur Pathologie, Charite Universitatsmedizin Berlin, Berlin, Germany
    PLoS ONE 7:e51862. 2012
    ..Cutoff Finder is expected to fill a relevant gap in the available biometric software repertoire and will enable faster optimization of new diagnostic biomarkers. The tool can be accessed at http://molpath.charite.de/cutoff...
  16. doi request reprint The DNA index as a prognostic tool in hilar cholangiocarcinoma
    Carsten Kamphues
    Department of General, Visceral and Vascular Surgery, Charite, Campus Benjamin Franklin, Berlin, Germany
    J Surg Oncol 112:214-8. 2015
    ..The aim of this study was to analyze the predictive value of the DNA index in a large single-center cohort of patients undergoing resection of HCCA...
  17. doi request reprint Mutations in genes encoding PI3K-AKT and MAPK signaling define anogenital papillary hidradenoma
    Nicole Pfarr
    Institute of Pathology, Technical University Munich TUM, Trogerstrasse 18, Munich, 81675, Germany
    Genes Chromosomes Cancer 55:113-9. 2016
    ..Lastly, our genetic data may suggest treatment avenues beyond conventional surgery for some of these tumors. © 2015 Wiley Periodicals, Inc. ..
  18. pmc New network topology approaches reveal differential correlation patterns in breast cancer
    Michael Bockmayr
    Institute for Pathology, Charite University Hospital Berlin, Chariteplatz 1, 10117 Berlin, Germany
    BMC Syst Biol 7:78. 2013
    ..Currently, there is no gold standard for the detection of differential correlation and statistical validation...
  19. pmc Who is at risk for diagnostic discrepancies? Comparison of pre- and postmortal diagnoses in 1800 patients of 3 medical decades in East and West Berlin
    Daniel Wittschieber
    Institute of Pathology, Charite University Hospital, Berlin, Germany
    PLoS ONE 7:e37460. 2012
    ..The study aimed at analyzing current diagnostic discrepancy rates, investigating their influencing factors and identifying risk profiles of patients that could be affected by a diagnostic discrepancy...
  20. doi request reprint Postoperative complications deteriorate long-term outcome in pancreatic cancer patients
    Carsten Kamphues
    Department of General, Visceral and Transplantation Surgery, Charite, University Medicine, Berlin, Germany
    Ann Surg Oncol 19:856-63. 2012
    ..Furthermore, the impact of postoperative complications on patient long-term survival has not been described...
  21. doi request reprint Prolyl hydroxylase domain 2 protein is a strong prognostic marker in human gastric cancer
    Carsten Kamphues
    Department of General, Visceral and Transplantation Surgery, Charite University Hospital, Berlin, Germany
    Pathobiology 79:11-7. 2012
    ..The aim of this study was to evaluate PHD2 expression patterns in primary gastric adenocarcinoma and to test for a potential predictive value of PHD2 expression in gastric cancer patients...
  22. doi request reprint Distribution of MED12 mutations in fibroadenomas and phyllodes tumors of the breast--implications for tumor biology and pathological diagnosis
    Nicole Pfarr
    Institute of Pathology, University Hospital Heidelberg, Im Neuenheimer Feld 224, 69120, Heidelberg, Germany
    Genes Chromosomes Cancer 54:444-52. 2015
    ....
  23. pmc Metabolomics of human breast cancer: new approaches for tumor typing and biomarker discovery
    Carsten Denkert
    Institute of Pathology, Charite Universitatsmedizin Berlin, 10117 Berlin, Germany
    Genome Med 4:37. 2012
    ..We predict an intensified use of metabolomic screens in clinical and preclinical studies focusing on the onset and progression of tumor development...
  24. doi request reprint Strategies for developing Ki67 as a useful biomarker in breast cancer
    Carsten Denkert
    Institute of Pathology, Charite Universitatsmedizin Berlin, Germany German Cancer Consortium DKTK, Berlin, Germany German Breast Group, Neu Isenburg, Germany Electronic address
    Breast 24:S67-72. 2015
    ..Despite these limitations, the assessment of proliferation is a central parameter for tumor characterization and an important element of the pathological assessment...
  25. doi request reprint KRAS mutations in codon 12 or 13 are associated with worse prognosis in pancreatic ductal adenocarcinoma
    Bruno V Sinn
    From the Departments of Pathology, Hematology, Oncology and Tumor Immunology, and General, Visceral, and Transplantation Surgery, Charite Universitatsmedizin Berlin, Berlin and Department of Pathology, University Hospital Heidelberg, Heidelberg, Germany
    Pancreas 43:578-83. 2014
    ..In addition, we attempted to define molecular subgroups with distinct biologic behavior by combination of KRAS sequencing data with p53 protein expression data...
  26. doi request reprint ALK-FISH borderline cases in non-small cell lung cancer: Implications for diagnostics and clinical decision making
    Maximilian von Laffert
    Institute of Pathology, Charite Universitatsmedizin, Chariteplatz 1, 10117 Berlin, Germany
    Lung Cancer 90:465-71. 2015
    ..However, NSCLC with SS-counts around the cut-off may cause interpretation problems...
  27. doi request reprint Semiconductor sequencing: how many flows do you need?
    Jan Budczies
    Institute of Pathology, Charite University Hospital, Chariteplatz 1, 10117 Berlin, Germany, German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany and German Consortium for Translational Cancer Research DKTK, Berlin Partner Site, Chariteplatz 1, 10117 Berlin, Germany Institute of Pathology, Charite University Hospital, Chariteplatz 1, 10117 Berlin, Germany, German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany and German Consortium for Translational Cancer Research DKTK, Berlin Partner Site, Chariteplatz 1, 10117 Berlin, Germany Institute of Pathology, Charite University Hospital, Chariteplatz 1, 10117 Berlin, Germany, German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany and German Consortium for Translational Cancer Research DKTK, Berlin Partner Site, Chariteplatz 1, 10117 Berlin, Germany
    Bioinformatics 31:1199-203. 2015
    ..To minimize time requirement and costs, it is necessary to know the number of flows that are required for complete coverage of the templates...
  28. pmc Mutations in POLE and survival of colorectal cancer patients--link to disease stage and treatment
    Albrecht Stenzinger
    Institute of Pathology, Heidelberg University Hospital, Germany
    Cancer Med 3:1527-38. 2014
    ....
  29. doi request reprint BRAF V600E-specific immunohistochemistry reveals low mutation rates in biliary tract cancer and restriction to intrahepatic cholangiocarcinoma
    Benjamin Goeppert
    Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany
    Mod Pathol 27:1028-34. 2014
    ....
  30. doi request reprint Decreased RECK and Increased EMMPRIN expression in urothelial carcinoma of the bladder are associated with tumor aggressiveness
    Daniel Wittschieber
    Institute of Pathology, Charite University Hospital, Berlin, Germany d wittschieber gmx de
    Pathobiology 78:123-31. 2011
    ..This study aims to investigate the expression of RECK and EMMPRIN in urothelial carcinoma of the bladder and to correlate these findings with clinicopathological parameters...
  31. doi request reprint Would Virchow be a systems biologist? A discourse on the philosophy of science with implications for pathological research
    Albrecht Stenzinger
    Institute of Pathology, Charite Universitatsmedizin Berlin, Chariteplatz 1, 10117, Berlin, Germany
    Virchows Arch 456:599-607. 2010
    ..A focus is on the fields of "-omics" and systems pathology...
  32. doi request reprint Integration of metabolomics and expression of glycerol-3-phosphate acyltransferase (GPAM) in breast cancer-link to patient survival, hormone receptor status, and metabolic profiling
    Scarlet F Brockmöller
    Institute of Pathology, Charite Universitatsmedizin Berlin, 10117 Berlin, Germany
    J Proteome Res 11:850-60. 2012
    ....
  33. doi request reprint Marginal zone lymphomas with monocytoid morphology express T-bet and are associated with a low number of T cells in extranodal locations
    Philipp Lohneis
    Institute of Pathology, Charite Universitatsmedizin Berlin, Berlin, Germany
    Leuk Lymphoma 55:143-8. 2014
    ..In analogy to reactive monocytoid B lymphocytes, we also found a significantly lower relative amount of intratumoral T lymphocytes in extranodal MZL with monocytoid morphology...