Affiliation: Humboldt University
Kempkensteffen C, Christoph F, Weikert S, Krause H, Kollermann J, Schostak M, et al
. Epigenetic silencing of the putative tumor suppressor gene testisin in testicular germ cell tumors. J Cancer Res Clin Oncol. 2006;132:765-70 pubmed
..Our results demonstrate for the first time that aberrant methylation of specific CpG sites near the transcription initiation site is an important factor in testisin gene silencing in TGCT. ..
Kempkensteffen C, Hinz S, Christoph F, Kollermann J, Krause H, Schrader M, et al
. Expression parameters of the inhibitors of apoptosis cIAP1 and cIAP2 in renal cell carcinomas and their prognostic relevance. Int J Cancer. 2007;120:1081-6 pubmed
..001). The results of uni- and multivariate analysis suggest a prognostic value of cIAP1 expression for RCC patients, downregulation indicating an aggressive, potentially lethal phenotype. ..
Kempkensteffen C, Hinz S, Schrader M, Christoph F, Magheli A, Krause H, et al
. Gene expression and promoter methylation of the XIAP-associated Factor 1 in renal cell carcinomas: correlations with pathology and outcome. Cancer Lett. 2007;254:227-35 pubmed
..Promoter methylation may be one, but probably not the essential mechanism for transcriptional downregulation of the XAF1 gene in RCC. ..
Kempkensteffen C, Hinz S, Krause H, Jager T, Kollermann J, Weikert S, et al
. Expression of splicing variants of the inhibitor of apoptosis livin in testicular germ cell tumors. Tumour Biol. 2008;29:76-82 pubmed publisher
..Considering that livin expression is restricted to malignant testicular tissue, it appears reasonable to conduct further investigations regarding its targeted inhibition in TGCT. ..
Kempkensteffen C, Hinz S, Jager T, Weikert S, Krause H, Schostak M, et al
. [Expression levels of the IAP antagonists XAF1, Smac/DIABLO and HtrA2 in testicular germ cell tumours]. Aktuelle Urol. 2008;39:436-41 pubmed publisher
..We examined the mRNA-expression of these pro-apoptotic parameters in testicular germ cell tumors (TGCT) and normal testicular tissue and correlated their expression levels to clinicopathological tumour features...
Kempkensteffen C, Hinz S, Christoph F, Krause H, Koellermann J, Magheli A, et al
. Expression of the apoptosis inhibitor livin in renal cell carcinomas: correlations with pathology and outcome. Tumour Biol. 2007;28:132-8 pubmed
..Our findings suggest that livin expression in RCC is not of prognostic relevance. Further studies to clarify the role of livin expression in RCC and its potential value as a target for immune-mediated tumor destruction are warranted. ..
Kempkensteffen C, Hinz S, Christoph F, Krause H, Magheli A, Schrader M, et al
. Expression levels of the mitochondrial IAP antagonists Smac/DIABLO and Omi/HtrA2 in clear-cell renal cell carcinomas and their prognostic value. J Cancer Res Clin Oncol. 2008;134:543-50 pubmed
..Our data suggest that expression of Smac/DIABLO, but not Omi/HtrA2, is inversely associated with outcome of RCC patients. ..
Kempkensteffen C, Hinz S, Johannsen M, Krause H, Magheli A, Christoph F, et al
. Expression of Mcl-1 splicing variants in clear-cell renal cancer and their correlation with histopathological parameters and prognosis. Tumour Biol. 2009;30:73-9 pubmed publisher
..004 and p = 0.011). These findings suggest Mcl-1L to provide a molecular parameter for outcome prediction in ccRCC patients, down-regulation indicating exceptionally aggressive tumour phenotypes. ..
Kempkensteffen C, Fritzsche F, Johannsen M, Weikert S, Hinz S, Dietel M, et al
. Down-regulation of the pro-apoptotic XIAP associated factor-1 (XAF1) during progression of clear-cell renal cancer. BMC Cancer. 2009;9:276 pubmed publisher