Research Topics
Genomes and GenesSpecies | Klaus KayserSummaryAffiliation: Humboldt University Country: Germany Publications
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Detail Information
Publications
The concept of structural entropy in tissue-based diagnosisKlaus Kayser
UICC Telepathology Consultation Center, Charite, Berlin, Germany
Anal Quant Cytol Histol 29:296-308. 2007....
Diagnostic pathology in 2012: development of digital pathology in an open access journalKlaus Kayser
Charite, Homboldt University, Berlin, Germany
Diagn Pathol 8:3. 2013..VIRTUAL SLIDE: http://www.diagnosticpathology.diagnomx.eu/vs/1944221953867351...
How to introduce virtual microscopy (VM) in routine diagnostic pathology: constraints, ideas, and solutionsKlaus Kayser
Charite, University of Berlin, Germany
Anal Cell Pathol (Amst) 35:3-10. 2012..Until today, only a few pathology institutions take use of this new technology, although it is available since several years. Why?..- Introduction of virtual microscopy in routine surgical pathology--a hypothesis and personal view from EuropeKlaus Kayser
Institute of Pathology, Charite, Charite Platz 1, D 10117, Berlin, Germany
Diagn Pathol 7:48. 2012..VIRTUAL SLIDES: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1245603103708547... - Virtual slides in peer reviewed, open access medical publicationKlaus Kayser
Institute of Pathology, Charite, Berlin, Germany
Diagn Pathol 6:124. 2011..VIRTUAL SLIDES: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1232133347629819... - Mesothelioma and asbestosis in a young woman following occupational asbestos exposure: Short latency and long survival: Case ReportEnrique Bitchatchi
Unit of Occupational and Environmental Medicine, Braun School of Public Health and Community Medicine, Faculty of Medicine, Hebrew University, Jerusalem, Israel
Diagn Pathol 5:81. 2010..The patient is alive and well 12 years after diagnosis and 14 years after onset of symptoms. The combination of an extremely short latency period and long survival following occupational exposure to asbestos dust is unique... - The journey of Diagnostic Pathology in 2009, perspectives for 2010Klaus Kayser
UICC TPCC, Institute of Pathology, Charite, Berlin, Germany
Diagn Pathol 4:47. 2009..EDITORIAL: The journey of Diagnostic Pathology in 2009, perspectives for 2010... - Grid technology in tissue-based diagnosis: fundamentals and potential developmentsJürgen Görtler
IBM DeepComputing, Brussels, Belgium
Diagn Pathol 1:23. 2006..As a result Grid technology offers a new dimension to access distributed information and knowledge and to improving the quality in tissue-based diagnosis and therefore improving the medical quality... - Grid computing in image analysisKlaus Kayser
UICC TPCC, Charite, Berlin, Germany
Diagn Pathol 6:S12. 2011.... - Localized fibrous tumors (LFTs) of the pleura: clinical data, asbestos burden, and syntactic structure analysis applied to newly defined angiogenic/growth-regulatory effectorsKlaus Kayser
UICC TPCC, Institute of Pathology, Charite, Berlin, Germany
Pathol Res Pract 201:791-801. 2005..Considering the galectin network, differential expression was noted with preference to effectors limiting growth and aggressiveness... - Digitized pathology: theory and experiences in automated tissue-based virtual diagnosisK Kayser
UICC TPCC, Institute of Pathology, Charite, University of Berlin, Germany
Rom J Morphol Embryol 47:21-8. 2006..Object information requires image segmentation and feature extraction. Both algorithms complete another to a "self-learning" classification system... - How to measure image quality in tissue-based diagnosis (diagnostic surgical pathology)Klaus Kayser
UICC TPCC, Institute of Pathology, Charite, Berlin, Germany
Diagn Pathol 3:S11. 2008..Automated image analysis, measurements of virtual slides, and open access electronic measurement user systems require standardized image quality assessment in tissue-based diagnosis... - Texture- and object-related automated information analysis in histological still images of various organsKlaus Kayser
Institute of Pathology, The International Union Against Cancer Telepathology Consultation Center, Charite, Charite Platz 1, D 10117 Berlin, Germany
Anal Quant Cytol Histol 30:323-35. 2008..To create algorithms and application tools that can support routine diagnoses of various organs... - AI (artificial intelligence) in histopathology--from image analysis to automated diagnosisKlaus Kayser
UICC TPCC, Institute of Pathology, Charite, Berlin, Germany
Folia Histochem Cytobiol 47:355-61. 2009..Its accurate use will give them the time needed to concentrating on difficult cases for the benefit of their patients... - History and structures of telecommunication in pathology, focusing on open access platformsKlaus Kayser
Charite, University of Berlin, Berlin, Germany
Diagn Pathol 6:110. 2011..the new generation offers additional benefits such as acoustic information transfer, assistance in image screening, VS technology, and teaching in diagnostic sampling, judgement, and verification... - Interactive and automated application of virtual microscopyKlaus Kayser
UICC TPCC, Charite, Berlin, Germany
Diagn Pathol 6:S10. 2011..The advantages of such a system as well as the present pathology environment and its expectations will be discussed in detail... - E-education in pathology including certification of e-institutionsKlaus Kayser
UICC TPCC, Charite, Charite Platz 1, 10118 Berlin, Germany
Diagn Pathol 6:S11. 2011.... - How to measure diagnosis-associated information in virtual slidesKlaus Kayser
UICC TPCC, Charite, Berlin, Germany
Diagn Pathol 6:S9. 2011..The different algorithms can be combined to a basic technique of field of view selection, and a general theory of "image information" can be derived. The advantages and constraints of the applied methods will be discussed... - Phenotype and genotype associations of lung carcinoma with atypical adenomatoid hyperplasia, squamous cell dysplasia, and chromosome alterations in non-neoplastic bronchial mucosaK Kayser
UICC TPCC, Institute of Pathology, Charite, Berlin, Germany
Rom J Morphol Embryol 46:5-10. 2005..Data indicate that the so-called preneoplastic lesions in the lung are not completely tumor-precursor lesions, but, in addition, induced by the tumor itself... - Image standards in tissue-based diagnosis (diagnostic surgical pathology)Klaus Kayser
UICC TPCC, Institute of Pathology, Charite, Berlin, Germany
Diagn Pathol 3:17. 2008..Progress in automated image analysis, virtual microscopy, hospital information systems, and interdisciplinary data exchange require image standards to be applied in tissue-based diagnosis... - To be at the right place at the right timeKlaus Kayser
Institute of Pathology, Charite, Chariteplatz 1, D 10118 Berlin, Germany
Diagn Pathol 6:2-9. 2011..To include the theory of hierarchic order of structures and aspects of thermodynamically open systems, especially entropy, structural entropy and entropy flow... - From telepathology to virtual pathology institution: the new world of digital pathologyK Kayser
UICC TPCC, Institute of Pathology, Charite, Berlin, Germany
Rom J Morphol Embryol 45:3-9. 1999..Industrial and scientific efforts will probably allow an implementation of this technique within the next two years with exciting diagnostic and scientific perspectives... - Atypical adenomatous hyperplasia of lung: its incidence and analysis of clinical, glycohistochemical and structural features including newly defined growth regulators and vascularizationKlaus Kayser
UICC TPCC, Institute of Pathology, Charite, Humboldt University, Schumannstr 20 23, D 10117 Berlin, Germany
Lung Cancer 42:171-82. 2003..The paucity of data about cellular and vascular characteristics of this lesion in comparison to normal lung prompted this investigation... - Chromosomal aberrations, profiles of expression of growth-related markers including galectins and environmental hazards in relation to the incidence of chondroid pulmonary hamartomasKlaus Kayser
UICC Telepathology Consultation Center, Institute of Pathology, Charite, Humboldt University, Berlin, Germany
Pathol Res Pract 199:589-98. 2003..These results contribute to the definition of biochemical characteristics in hamartomas and can be useful for distinguishing them from chronic degenerative disorders... - New developments in digital pathology: from telepathology to virtual pathology laboratoryKlaus Kayser
UICC-TPCC, Institute of Pathology, Charite, Berlin, Germany
Stud Health Technol Inform 105:61-9. 2004..Industrial and scientific efforts will probably allow an implementation of this technique within the next two years... - Lung carcinoma-associated atypical adenomatoid hyperplasia, squamous cell dysplasia, and chromosome alterations in non-neoplastic bronchial mucosaKlaus Kayser
UICC TPCC, Institute of Pathology, Charite, Schumann Str 20 21, D 10168 Berlin, Germany
Lung Cancer 47:205-14. 2005..The data suggest the hypothesis that preneoplastic lesions in the lung might be partly induced by the tumor itself... - Expression, proliferation activity and clinical significance of cathepsin B and cathepsin L in operated lung cancerKlaus Kayser
Institute of Pathology, Charite, Berlin, Germany
Anticancer Res 23:2767-72. 2003..To immunohistochemically investigate the expression of cathepsin B and cathepsin L in various lung cancer cell types in association with the patients' prognosis... - Numerical and structural centrosome aberrations are an early and stable event in the adenoma-carcinoma sequence of colorectal carcinomasGian Kayser
Institute of Pathology, University Hospital Freiburg, Germany
Virchows Arch 447:61-5. 2005.... - How to implement grid technology in tissue-based diagnosis: diagnostic surgical pathologyKlaus Kayser
UICC TPCC, Institute of Pathology, Charite, Charite Platz 1, D 10118, Berlin, Germany
Expert Opin Med Diagn 2:323-37. 2008..Conclusions: Grid technology is probably a useful tool to meet the conditions of tissue-based diagnosis in the near future, and will probably play a significant role in its further development... - Vascular diffusion density and survival of patients with primary lung carcinomasGian Kayser
Institute of Pathology, University Freiburg, Germany
Virchows Arch 442:462-7. 2003..To investigate the clinical significance of tumour vascularisation in operated lung cancer patients... - Frequent overexpression of the genes FXR1, CLAPM1 and EIF4G located on amplicon 3q26-27 in squamous cell carcinoma of the lungNicole Comtesse
Department of Human Genetics, Medical School, Saarland University, Homburg, Germany
Int J Cancer 120:2538-44. 2007..Our results contribute to the understanding of the frequent amplification processes in squamous cell carcinomas of the lung and to the understanding of the translation initiation that appears not to require eIF4E in lung carcinogenesis... - Association between the risk for lung adenocarcinoma and a (-4) G-to-A polymorphism in the XPA geneDorota Butkiewicz
Division of Toxicology and Cancer Risk Factors, German Cancer Research Center, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
Cancer Epidemiol Biomarkers Prev 13:2242-6. 2004..The underlying mechanisms as to why AA homozygotes are predisposed to lung adenocarcinoma and which specific carcinogens are involved remains to be determined... - Presentation of NO-metabolites (nitrate/nitrite) in blood serum and pleural effusions from cancer patients with pleurisyAlexander V Timoshenko
Institute of Photobiology, National Academy of Sciences of Belarus, Minsk, Belarus
Cancer Lett 182:93-9. 2002..Besides, a casual effectiveness of NOx measurements in native samples from cancer patients using Griess reagent needs additional elaboration... - Structure-activity profiles of complex biantennary glycans with core fucosylation and with/without additional alpha 2,3/alpha 2,6 sialylation: synthesis of neoglycoproteins and their properties in lectin assays, cell binding, and organ uptakeCarlo Unverzagt
Institut fur Organische Chemie und Biochemie, Technische Universitat Munchen, Lichtenbergstrasse 4, 85748 Garching, Germany
J Med Chem 45:478-91. 2002..Overall, our study underscores the importance of chemoenzymatic synthesis to define the effect of chain orientation on the ligand properties of N-glycans... - Myeloperoxidase (MPO) genotype and lung cancer histologic types: the MPO -463 A allele is associated with reduced risk for small cell lung cancer in smokersHeike Dally
Division of Toxicology and Cancer Risk Factors, German Cancer Research Center, Heidelberg, Germany
Int J Cancer 102:530-5. 2002..We confirm that the MPO -463 A variant affords a protective effect against lung cancer risk in smokers, which was strongest for SCLC patients... - Association of galectin-1- but not galectin-3-dependent parameters with proliferation activity in human neuroblastomas and small cell lung carcinomasHans-Joachim Gabius
, , , Munich, Germany
Anticancer Res 22:405-10. 2002.... - Overexpression of the eukaryotic translation initiation factor 4G (eIF4G-1) in squamous cell lung carcinomaChristine Bauer
, , , Homburg/Saar, Germany
Int J Cancer 98:181-5. 2002..Overexpression of eIF4G-1 may result in an increased amount of the translation initiation complex eIF4F, which in turn may activate the translation of the same target mRNAs as eIF4E... - Primary colorectal carcinomas and their intrapulmonary metastases: clinical, glyco-, immuno- and lectin histochemical, nuclear and syntactic structure analysis with emphasis on correlation with period of occurrence of metastases and survivalKlaus Kayser
Department of Pathology, Thoraxklinik, Heidelberg, Germany
APMIS 110:435-46. 2002..The aim of the study was to correlate clinical factors (disease-free interval/survival) with growth pattern in terms of structural entropy of patients with primary colorectal carcinomas and secondary lung lesions... - The CYP3A4*1B allele increases risk for small cell lung cancer: effect of gender and smoking doseHeike Dally
Division of Toxicology and Cancer Risk Factors, German Cancer Research Center DKFZ, Heidelberg, Germany
Pharmacogenetics 13:607-18. 2003..To confirm our observation that the CYP3A4*1B allele increases SCLC risk and modifies the smoking-related lung cancer risk in a gender-specific manner, further studies, including CYP3A haplotype analysis, will be necessary... - Prognostic significance of microvascularization in cases of operated lung cancerTamas Szoke
Department of Surgery, University of Szeged, Pécsi u 4, H 6720 Szeged, Hungary
Eur J Cardiothorac Surg 27:1106-11. 2005..Measurement of microvascularization and determination of its prognostic significance in cases of lung cancer... - Theory and implementation of an electronic, automated measurement system for images obtained from immunohistochemically stained slidesGian Kayser
Institute of Pathology, University Hospital Freiburg
Anal Quant Cytol Histol 28:27-38. 2006.... - [Prognostic role of microvascularization in surgically treated lung cancer]Tamas Szoke
Sebészeti Klinika, Szegedi Tudomanyegyetem, Szeged 6720, Hungary
Magy Onkol 50:47-53. 2006..The aim of our study was the determination of microvascularization and its prognostic significance in lung cancer patients... - Cystatins in non-small cell lung cancer: tissue levels, localization and relation to prognosisBernd Werle
Abteilung für Klinische Chemie und Bakteriologie, Thoraxklinik Heidelberg gGmbH, D 69117 Heidelberg, Germany
Oncol Rep 16:647-55. 2006..As biological markers they may add independent prognostic information for better assessment of low- and high-risk patients with NSCLC... - The role of microvascularization and growth/adhesion-regulatory lectins in the prognosis of non-small cell lung cancer in stage IITamas Szoke
Department of Surgery, University of Szeged, Szeged, Hungary
Eur J Cardiothorac Surg 31:783-7. 2007..To investigate the role of growth/adhesion-regulatory lectins in the prognosis of the stage II non-small cell lung carcinomas (NSCLCs) via quantitative lectinhistochemical examinations and measurement of microvascularization of the tumour... - Pharmacokinetic analysis of malignant pleural mesothelioma-initial results of tumor microcirculation and its correlation to microvessel density (CD-34)Frederik L Giesel
Radiologie, German Cancer Research Center DKFZ, INF 280, 69120 Heidelberg, Germany
Acad Radiol 15:563-70. 2008..We employed dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and quantitative immunohistochemistry (IHC) to characterize the microvascularity of MM using both a physiologic and ultrastructural method... - Specific combinations of DNA repair gene variants and increased risk for non-small cell lung cancerOdilia Popanda
Division of Toxicology and Cancer Risk Factors, German Cancer Research Center DKFZ, Heidelberg, Germany
Carcinogenesis 25:2433-41. 2004..Analyses of additional DNA repair gene interactions in larger population-based studies are warranted for identification of high-risk subjects... - Genotype relationships in the CYP3A locus in CaucasiansHeike Dally
Deutsches Krebsforschungszentrum, Abteilung Toxikologie und Krebsrisikofaktoren, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
Cancer Lett 207:95-9. 2004.... - Prognostic significance of endogenous adhesion/growth-regulatory lectins in lung cancerTamas Szoke
Department of Surgery, University of Szeged, Szeged, Hungary
Oncology 69:167-74. 2005..To determine the expression of endogenous adhesion/growth-regulatory lectins and their binding sites using labeled tissue lectins as well as the binding profile of hyaluronic acid as an approach to define new prognostic markers...