Klaus Kayser

Summary

Affiliation: Humboldt University
Country: Germany

Publications

  1. ncbi request reprint The concept of structural entropy in tissue-based diagnosis
    Klaus Kayser
    UICC Telepathology Consultation Center, Charite, Berlin, Germany
    Anal Quant Cytol Histol 29:296-308. 2007
  2. doi request reprint How to introduce virtual microscopy (VM) in routine diagnostic pathology: constraints, ideas, and solutions
    Klaus Kayser
    Charite, University of Berlin, Germany
    Anal Cell Pathol (Amst) 35:3-10. 2012
  3. pmc Quantification of virtual slides: Approaches to analysis of content-based image information
    Klaus Kayser
    UICC TPCC, Institute of Pathology, Charite, Charite Platz, D 10118 Berlin, Germany
    J Pathol Inform 2:2. 2011
  4. pmc Diagnostic pathology in 2013: facts, thoughts, and perspectives
    Klaus Kayser
    Humbold University Berlin, Charite Platz 1, Berlin, Germany
    Diagn Pathol 9:2. 2014
  5. pmc Diagnostic pathology in 2012: development of digital pathology in an open access journal
    Klaus Kayser
    Charite, Homboldt University, Berlin, Germany
    Diagn Pathol 8:3. 2013
  6. pmc Introduction of virtual microscopy in routine surgical pathology--a hypothesis and personal view from Europe
    Klaus Kayser
    Institute of Pathology, Charite, Charite Platz 1, D 10117, Berlin, Germany
    Diagn Pathol 7:48. 2012
  7. pmc Virtual slides in peer reviewed, open access medical publication
    Klaus Kayser
    Institute of Pathology, Charite, Berlin, Germany
    Diagn Pathol 6:124. 2011
  8. pmc Mesothelioma and asbestosis in a young woman following occupational asbestos exposure: Short latency and long survival: Case Report
    Enrique Bitchatchi
    Unit of Occupational and Environmental Medicine, Braun School of Public Health and Community Medicine, Faculty of Medicine, Hebrew University, Jerusalem, Israel
    Diagn Pathol 5:81. 2010
  9. pmc The journey of Diagnostic Pathology in 2009, perspectives for 2010
    Klaus Kayser
    UICC TPCC, Institute of Pathology, Charite, Berlin, Germany
    Diagn Pathol 4:47. 2009
  10. pmc Grid technology in tissue-based diagnosis: fundamentals and potential developments
    Jürgen Görtler
    IBM DeepComputing, Brussels, Belgium
    Diagn Pathol 1:23. 2006

Collaborators

Detail Information

Publications59

  1. ncbi request reprint The concept of structural entropy in tissue-based diagnosis
    Klaus Kayser
    UICC Telepathology Consultation Center, Charite, Berlin, Germany
    Anal Quant Cytol Histol 29:296-308. 2007
    ....
  2. doi request reprint How to introduce virtual microscopy (VM) in routine diagnostic pathology: constraints, ideas, and solutions
    Klaus Kayser
    Charite, University of Berlin, Germany
    Anal Cell Pathol (Amst) 35:3-10. 2012
    ..Until today, only a few pathology institutions take use of this new technology, although it is available since several years. Why?..
  3. pmc Quantification of virtual slides: Approaches to analysis of content-based image information
    Klaus Kayser
    UICC TPCC, Institute of Pathology, Charite, Charite Platz, D 10118 Berlin, Germany
    J Pathol Inform 2:2. 2011
    ..They contribute to the derived diagnosis to a higher level when compared with other image areas. The implementation of content-based image information algorithms to be applied for predictive tissue-based diagnoses is described in detail...
  4. pmc Diagnostic pathology in 2013: facts, thoughts, and perspectives
    Klaus Kayser
    Humbold University Berlin, Charite Platz 1, Berlin, Germany
    Diagn Pathol 9:2. 2014
    ..Herein we analyze the development of the open access, peer reviewed journal Diagnostic Pathology (http://www.diagnosticpathology.org) during the past year and try to forecast its perspectives in 2014...
  5. pmc Diagnostic pathology in 2012: development of digital pathology in an open access journal
    Klaus Kayser
    Charite, Homboldt University, Berlin, Germany
    Diagn Pathol 8:3. 2013
    ..VIRTUAL SLIDE: http://www.diagnosticpathology.diagnomx.eu/vs/1944221953867351...
  6. pmc Introduction of virtual microscopy in routine surgical pathology--a hypothesis and personal view from Europe
    Klaus Kayser
    Institute of Pathology, Charite, Charite Platz 1, D 10117, Berlin, Germany
    Diagn Pathol 7:48. 2012
    ..It focuses on describing the advantages of modern and innovative electronically based communication technology...
  7. pmc Virtual slides in peer reviewed, open access medical publication
    Klaus Kayser
    Institute of Pathology, Charite, Berlin, Germany
    Diagn Pathol 6:124. 2011
    ....
  8. pmc Mesothelioma and asbestosis in a young woman following occupational asbestos exposure: Short latency and long survival: Case Report
    Enrique Bitchatchi
    Unit of Occupational and Environmental Medicine, Braun School of Public Health and Community Medicine, Faculty of Medicine, Hebrew University, Jerusalem, Israel
    Diagn Pathol 5:81. 2010
    ..The patient is alive and well 12 years after diagnosis and 14 years after onset of symptoms. The combination of an extremely short latency period and long survival following occupational exposure to asbestos dust is unique...
  9. pmc The journey of Diagnostic Pathology in 2009, perspectives for 2010
    Klaus Kayser
    UICC TPCC, Institute of Pathology, Charite, Berlin, Germany
    Diagn Pathol 4:47. 2009
    ..EDITORIAL: The journey of Diagnostic Pathology in 2009, perspectives for 2010...
  10. pmc Grid technology in tissue-based diagnosis: fundamentals and potential developments
    Jürgen Görtler
    IBM DeepComputing, Brussels, Belgium
    Diagn Pathol 1:23. 2006
    ..As a result Grid technology offers a new dimension to access distributed information and knowledge and to improving the quality in tissue-based diagnosis and therefore improving the medical quality...
  11. pmc How to measure image quality in tissue-based diagnosis (diagnostic surgical pathology)
    Klaus Kayser
    UICC TPCC, Institute of Pathology, Charite, Berlin, Germany
    Diagn Pathol 3:S11. 2008
    ..Automated image analysis, measurements of virtual slides, and open access electronic measurement user systems require standardized image quality assessment in tissue-based diagnosis...
  12. pmc History and structures of telecommunication in pathology, focusing on open access platforms
    Klaus Kayser
    Charite, University of Berlin, Berlin, Germany
    Diagn Pathol 6:110. 2011
    ..Telecommunication has matured to a broadly applied tool in diagnostic pathology...
  13. pmc To be at the right place at the right time
    Klaus Kayser
    Institute of Pathology, Charite, Chariteplatz 1, D 10118 Berlin, Germany
    Diagn Pathol 6:2-9. 2011
    ..To include the theory of hierarchic order of structures and aspects of thermodynamically open systems, especially entropy, structural entropy and entropy flow...
  14. pmc Grid computing in image analysis
    Klaus Kayser
    UICC TPCC, Charite, Berlin, Germany
    Diagn Pathol 6:S12. 2011
    ....
  15. pmc How to measure diagnosis-associated information in virtual slides
    Klaus Kayser
    UICC TPCC, Charite, Berlin, Germany
    Diagn Pathol 6:S9. 2011
    ..The different algorithms can be combined to a basic technique of field of view selection, and a general theory of "image information" can be derived. The advantages and constraints of the applied methods will be discussed...
  16. pmc Image standards in tissue-based diagnosis (diagnostic surgical pathology)
    Klaus Kayser
    UICC TPCC, Institute of Pathology, Charite, Berlin, Germany
    Diagn Pathol 3:17. 2008
    ..Progress in automated image analysis, virtual microscopy, hospital information systems, and interdisciplinary data exchange require image standards to be applied in tissue-based diagnosis...
  17. pmc E-education in pathology including certification of e-institutions
    Klaus Kayser
    UICC TPCC, Charite, Charite Platz 1, 10118 Berlin, Germany
    Diagn Pathol 6:S11. 2011
    ....
  18. ncbi request reprint Texture- and object-related automated information analysis in histological still images of various organs
    Klaus Kayser
    Institute of Pathology, The International Union Against Cancer Telepathology Consultation Center, Charite, Charite Platz 1, D 10117 Berlin, Germany
    Anal Quant Cytol Histol 30:323-35. 2008
    ..To create algorithms and application tools that can support routine diagnoses of various organs...
  19. pmc Interactive and automated application of virtual microscopy
    Klaus Kayser
    UICC TPCC, Charite, Berlin, Germany
    Diagn Pathol 6:S10. 2011
    ..The advantages of such a system as well as the present pathology environment and its expectations will be discussed in detail...
  20. doi request reprint AI (artificial intelligence) in histopathology--from image analysis to automated diagnosis
    Klaus Kayser
    UICC TPCC, Institute of Pathology, Charite, Berlin, Germany
    Folia Histochem Cytobiol 47:355-61. 2009
    ..Its accurate use will give them the time needed to concentrating on difficult cases for the benefit of their patients...
  21. ncbi request reprint Digitized pathology: theory and experiences in automated tissue-based virtual diagnosis
    K Kayser
    UICC TPCC, Institute of Pathology, Charite, University of Berlin, Germany
    Rom J Morphol Embryol 47:21-8. 2006
    ..Texture information can be derived by recursive formulas without image segmentation. Object information requires image segmentation and feature extraction. Both algorithms complete another to a "self-learning" classification system...
  22. ncbi request reprint From telepathology to virtual pathology institution: the new world of digital pathology
    K Kayser
    UICC TPCC, Institute of Pathology, Charite, Berlin, Germany
    Rom J Morphol Embryol 45:3-9. 1999
    ..Industrial and scientific efforts will probably allow an implementation of this technique within the next two years with exciting diagnostic and scientific perspectives...
  23. ncbi request reprint Localized fibrous tumors (LFTs) of the pleura: clinical data, asbestos burden, and syntactic structure analysis applied to newly defined angiogenic/growth-regulatory effectors
    Klaus Kayser
    UICC TPCC, Institute of Pathology, Charite, Berlin, Germany
    Pathol Res Pract 201:791-801. 2005
    ..Considering the galectin network, differential expression was noted with preference to effectors limiting growth and aggressiveness...
  24. ncbi request reprint Phenotype and genotype associations of lung carcinoma with atypical adenomatoid hyperplasia, squamous cell dysplasia, and chromosome alterations in non-neoplastic bronchial mucosa
    K Kayser
    UICC TPCC, Institute of Pathology, Charite, Berlin, Germany
    Rom J Morphol Embryol 46:5-10. 2005
    ..Data indicate that the so-called preneoplastic lesions in the lung are not completely tumor-precursor lesions, but, in addition, induced by the tumor itself...
  25. ncbi request reprint Atypical adenomatous hyperplasia of lung: its incidence and analysis of clinical, glycohistochemical and structural features including newly defined growth regulators and vascularization
    Klaus Kayser
    UICC TPCC, Institute of Pathology, Charite, Humboldt University, Schumannstr 20 23, D 10117 Berlin, Germany
    Lung Cancer 42:171-82. 2003
    ..The paucity of data about cellular and vascular characteristics of this lesion in comparison to normal lung prompted this investigation...
  26. ncbi request reprint New developments in digital pathology: from telepathology to virtual pathology laboratory
    Klaus Kayser
    UICC TPCC, Institute of Pathology, Charite, Berlin, Germany
    Stud Health Technol Inform 105:61-9. 2004
    ..Industrial and scientific efforts will probably allow an implementation of this technique within the next two years...
  27. ncbi request reprint Chromosomal aberrations, profiles of expression of growth-related markers including galectins and environmental hazards in relation to the incidence of chondroid pulmonary hamartomas
    Klaus Kayser
    UICC Telepathology Consultation Center, Institute of Pathology, Charite, Humboldt University, Berlin, Germany
    Pathol Res Pract 199:589-98. 2003
    ..These results contribute to the definition of biochemical characteristics in hamartomas and can be useful for distinguishing them from chronic degenerative disorders...
  28. ncbi request reprint Lung carcinoma-associated atypical adenomatoid hyperplasia, squamous cell dysplasia, and chromosome alterations in non-neoplastic bronchial mucosa
    Klaus Kayser
    UICC TPCC, Institute of Pathology, Charite, Schumann Str 20 21, D 10168 Berlin, Germany
    Lung Cancer 47:205-14. 2005
    ..The data suggest the hypothesis that preneoplastic lesions in the lung might be partly induced by the tumor itself...
  29. ncbi request reprint Expression, proliferation activity and clinical significance of cathepsin B and cathepsin L in operated lung cancer
    Klaus Kayser
    Institute of Pathology, Charite, Berlin, Germany
    Anticancer Res 23:2767-72. 2003
    ..To immunohistochemically investigate the expression of cathepsin B and cathepsin L in various lung cancer cell types in association with the patients' prognosis...
  30. ncbi request reprint Numerical and structural centrosome aberrations are an early and stable event in the adenoma-carcinoma sequence of colorectal carcinomas
    Gian Kayser
    Institute of Pathology, University Hospital Freiburg, Germany
    Virchows Arch 447:61-5. 2005
    ..Here, we specifically address centrosome aberrations in the adenoma-carcinoma sequence of colorectal cancer by detailed evaluation of gamma-tubulin staining patterns...
  31. doi request reprint Quantitative pathology in virtual microscopy: history, applications, perspectives
    Gian Kayser
    Institute of Pathology, University Hospital Freiburg, Germany
    Acta Histochem 115:527-32. 2013
    ..The development and theoretical background of morphometric analyses in histopathology are reviewed, as well as their application and potential future implementation in virtual microscopy. ..
  32. doi request reprint How to implement grid technology in tissue-based diagnosis: diagnostic surgical pathology
    Klaus Kayser
    UICC TPCC, Institute of Pathology, Charite, Charite Platz 1, D 10118, Berlin, Germany
    Expert Opin Med Diagn 2:323-37. 2008
    ..Conclusions: Grid technology is probably a useful tool to meet the conditions of tissue-based diagnosis in the near future, and will probably play a significant role in its further development...
  33. ncbi request reprint Vascular diffusion density and survival of patients with primary lung carcinomas
    Gian Kayser
    Institute of Pathology, University Freiburg, Germany
    Virchows Arch 442:462-7. 2003
    ..To investigate the clinical significance of tumour vascularisation in operated lung cancer patients...
  34. ncbi request reprint Association between the risk for lung adenocarcinoma and a (-4) G-to-A polymorphism in the XPA gene
    Dorota Butkiewicz
    Division of Toxicology and Cancer Risk Factors, German Cancer Research Center, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Cancer Epidemiol Biomarkers Prev 13:2242-6. 2004
    ..The underlying mechanisms as to why AA homozygotes are predisposed to lung adenocarcinoma and which specific carcinogens are involved remains to be determined...
  35. ncbi request reprint Frequent overexpression of the genes FXR1, CLAPM1 and EIF4G located on amplicon 3q26-27 in squamous cell carcinoma of the lung
    Nicole Comtesse
    Department of Human Genetics, Medical School, Saarland University, Homburg, Germany
    Int J Cancer 120:2538-44. 2007
    ..Our results contribute to the understanding of the frequent amplification processes in squamous cell carcinomas of the lung and to the understanding of the translation initiation that appears not to require eIF4E in lung carcinogenesis...
  36. ncbi request reprint Structure-activity profiles of complex biantennary glycans with core fucosylation and with/without additional alpha 2,3/alpha 2,6 sialylation: synthesis of neoglycoproteins and their properties in lectin assays, cell binding, and organ uptake
    Carlo Unverzagt
    Institut fur Organische Chemie und Biochemie, Technische Universitat Munchen, Lichtenbergstrasse 4, 85748 Garching, Germany
    J Med Chem 45:478-91. 2002
    ..Overall, our study underscores the importance of chemoenzymatic synthesis to define the effect of chain orientation on the ligand properties of N-glycans...
  37. ncbi request reprint The role of microvascularization and growth/adhesion-regulatory lectins in the prognosis of non-small cell lung cancer in stage II
    Tamas Szoke
    Department of Surgery, University of Szeged, Szeged, Hungary
    Eur J Cardiothorac Surg 31:783-7. 2007
    ..To investigate the role of growth/adhesion-regulatory lectins in the prognosis of the stage II non-small cell lung carcinomas (NSCLCs) via quantitative lectinhistochemical examinations and measurement of microvascularization of the tumour...
  38. ncbi request reprint Overexpression of the eukaryotic translation initiation factor 4G (eIF4G-1) in squamous cell lung carcinoma
    Christine Bauer
    Institut fur Humangenetik, Universitatskliniken, Universitat des Saarlandes, Homburg Saar, Germany
    Int J Cancer 98:181-5. 2002
    ..Overexpression of eIF4G-1 may result in an increased amount of the translation initiation complex eIF4F, which in turn may activate the translation of the same target mRNAs as eIF4E...
  39. ncbi request reprint Association of galectin-1- but not galectin-3-dependent parameters with proliferation activity in human neuroblastomas and small cell lung carcinomas
    Hans Joachim Gabius
    Institut fur Physiologische Chemie, Tierarztliche Fakultat, Ludwig Maximilians Universitat, Munich, Germany
    Anticancer Res 22:405-10. 2002
    ..Owing to this capacity they might affect tumor growth when expression is adapted adequately...
  40. ncbi request reprint Presentation of NO-metabolites (nitrate/nitrite) in blood serum and pleural effusions from cancer patients with pleurisy
    Alexander V Timoshenko
    Institute of Photobiology, National Academy of Sciences of Belarus, Minsk, Belarus
    Cancer Lett 182:93-9. 2002
    ..Besides, a casual effectiveness of NOx measurements in native samples from cancer patients using Griess reagent needs additional elaboration...
  41. ncbi request reprint Primary colorectal carcinomas and their intrapulmonary metastases: clinical, glyco-, immuno- and lectin histochemical, nuclear and syntactic structure analysis with emphasis on correlation with period of occurrence of metastases and survival
    Klaus Kayser
    Department of Pathology, Thoraxklinik, Heidelberg, Germany
    APMIS 110:435-46. 2002
    ..The aim of the study was to correlate clinical factors (disease-free interval/survival) with growth pattern in terms of structural entropy of patients with primary colorectal carcinomas and secondary lung lesions...
  42. ncbi request reprint [Prognostic role of microvascularization in surgically treated lung cancer]
    Tamas Szoke
    Sebészeti Klinika, Szegedi Tudomanyegyetem, Szeged 6720, Hungary
    Magy Onkol 50:47-53. 2006
    ..The aim of our study was the determination of microvascularization and its prognostic significance in lung cancer patients...
  43. ncbi request reprint Myeloperoxidase (MPO) genotype and lung cancer histologic types: the MPO -463 A allele is associated with reduced risk for small cell lung cancer in smokers
    Heike Dally
    Division of Toxicology and Cancer Risk Factors, German Cancer Research Center, Heidelberg, Germany
    Int J Cancer 102:530-5. 2002
    ..We confirm that the MPO -463 A variant affords a protective effect against lung cancer risk in smokers, which was strongest for SCLC patients...
  44. doi request reprint Pharmacokinetic analysis of malignant pleural mesothelioma-initial results of tumor microcirculation and its correlation to microvessel density (CD-34)
    Frederik L Giesel
    Radiologie, German Cancer Research Center DKFZ, INF 280, 69120 Heidelberg, Germany
    Acad Radiol 15:563-70. 2008
    ..We employed dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and quantitative immunohistochemistry (IHC) to characterize the microvascularity of MM using both a physiologic and ultrastructural method...
  45. ncbi request reprint The CYP3A4*1B allele increases risk for small cell lung cancer: effect of gender and smoking dose
    Heike Dally
    Division of Toxicology and Cancer Risk Factors, German Cancer Research Center DKFZ, Heidelberg, Germany
    Pharmacogenetics 13:607-18. 2003
    ..To confirm our observation that the CYP3A4*1B allele increases SCLC risk and modifies the smoking-related lung cancer risk in a gender-specific manner, further studies, including CYP3A haplotype analysis, will be necessary...
  46. ncbi request reprint Theory and implementation of an electronic, automated measurement system for images obtained from immunohistochemically stained slides
    Gian Kayser
    Institute of Pathology, University Hospital Freiburg
    Anal Quant Cytol Histol 28:27-38. 2006
    ..To develop and implement an Internet-based, automated image measurement system for immunohistochemically stained slides including fluorescence images in online and off-line modes...
  47. ncbi request reprint Prognostic significance of endogenous adhesion/growth-regulatory lectins in lung cancer
    Tamas Szoke
    Department of Surgery, University of Szeged, Szeged, Hungary
    Oncology 69:167-74. 2005
    ..To determine the expression of endogenous adhesion/growth-regulatory lectins and their binding sites using labeled tissue lectins as well as the binding profile of hyaluronic acid as an approach to define new prognostic markers...
  48. ncbi request reprint Genotype relationships in the CYP3A locus in Caucasians
    Heike Dally
    Deutsches Krebsforschungszentrum, Abteilung Toxikologie und Krebsrisikofaktoren, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Cancer Lett 207:95-9. 2004
    ....
  49. ncbi request reprint Specific combinations of DNA repair gene variants and increased risk for non-small cell lung cancer
    Odilia Popanda
    Division of Toxicology and Cancer Risk Factors, German Cancer Research Center DKFZ, Heidelberg, Germany
    Carcinogenesis 25:2433-41. 2004
    ..Analyses of additional DNA repair gene interactions in larger population-based studies are warranted for identification of high-risk subjects...
  50. ncbi request reprint Prognostic significance of microvascularization in cases of operated lung cancer
    Tamas Szoke
    Department of Surgery, University of Szeged, Pécsi u 4, H 6720 Szeged, Hungary
    Eur J Cardiothorac Surg 27:1106-11. 2005
    ..Measurement of microvascularization and determination of its prognostic significance in cases of lung cancer...
  51. ncbi request reprint Cystatins in non-small cell lung cancer: tissue levels, localization and relation to prognosis
    Bernd Werle
    Abteilung für Klinische Chemie und Bakteriologie, Thoraxklinik Heidelberg gGmbH, D 69117 Heidelberg, Germany
    Oncol Rep 16:647-55. 2006
    ..As biological markers they may add independent prognostic information for better assessment of low- and high-risk patients with NSCLC...