Research Topics
Species | Grit KasperSummaryAffiliation: Humboldt University Country: Germany Publications
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Detail Information
Publications
Mesenchymal stem cells regulate angiogenesis according to their mechanical environmentGrit Kasper
Musculoskeletal Research Center Berlin, Charite Universitatsmedizin Berlin, Augustenburger Platz, 113353 Berlin, Germany
Stem Cells 25:903-10. 2007..The underlying mechanism appears to be dependent on the FGFR and VEGFR signaling cascades and might be mediated by an additional cross-talk with other pathways...
Stromelysin-3 over-expression enhances tumourigenesis in MCF-7 and MDA-MB-231 breast cancer cell lines: involvement of the IGF-1 signalling pathwayGrit Kasper
Musculoskeletal Research Center Berlin, Charite Universitatsmedizin Berlin, Berlin, Germany
BMC Cancer 7:12. 2007..Due to its known effect in promoting tumour formation, but its impeding effect on metastasis, a dual role of ST-3 in tumour progression, depending on the cellular grade of dedifferentiation, was hypothesized...- Matrix metalloprotease activity is an essential link between mechanical stimulus and mesenchymal stem cell behaviorGrit Kasper
Musculoskeletal Research Center Berlin, Charite Universitatsmedizin Berlin, Augustenburger Platz 1, Berlin, Germany
Stem Cells 25:1985-94. 2007..Thus, MMP/TIMP balance seems to play an essential role in transferring mechanical signals into MSC function. Disclosure of potential conflicts of interest is found at the end of this article... 
Modulation of matrix metalloprotease-2 levels by mechanical loading of three-dimensional mesenchymal stem cell constructs: impact on in vitro tube formationJuliane D Glaeser
Julius Wolff Institute and Center for Musculoskeletal Surgery, Charite Universitatsmedizin, Berlin, Germany
Tissue Eng Part A 16:3139-48. 2010..Thus, an application of these loading parameters could augment vascularization of tissue-engineered constructs based on the described MMP-2-dependent mechanism...- Toward biomimetic materials in bone regeneration: functional behavior of mesenchymal stem cells on a broad spectrum of extracellular matrix componentsAndrea Ode
Julius Wolff Institute, Charite Universitatsmedizin Berlin, Berlin, Germany
J Biomed Mater Res A 95:1114-24. 2010..Finally, on this basis, peptide sequences are reported for the potential stimulation of MSC functions. Based on the results of this study, ECM component coatings could be designed to specifically guide cell functions... - Sex-specific compromised bone healing in female rats might be associated with a decrease in mesenchymal stem cell quantityPatrick Strube
Center for Musculoskeletal Surgery and Julius Wolff Institute Berlin, Charite University Medicine Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
Bone 45:1065-72. 2009..Because mesenchymal stem cells (MSCs) are postulated to regulate tissue regeneration and give rise to essential differentiated cell types, they may contribute to sex-specific differences in bone healing outcomes... - Insights into mesenchymal stem cell aging: involvement of antioxidant defense and actin cytoskeletonGrit Kasper
Julius Wolff Institute and Center for Musculoskeletal Surgery Berlin, Charite Universitatsmedizin Berlin, Berlin, Germany
Stem Cells 27:1288-97. 2009.... - Cyclic strain disrupts endothelial network formation on MatrigelCameron J Wilson
Julius Wolff Institut and Center for Musculoskeletal Surgery, Charite Universitatsmedizin, Berlin, Germany
Microvasc Res 78:358-63. 2009..Most importantly, the results indicate that the straining of endothelial cells and their assembly into vascular-like structures must be studied simultaneously to adequately characterise the mechanical influence on vessel formation... - Mechanical stimulation of the pro-angiogenic capacity of human fracture haematoma: involvement of VEGF mechano-regulationAline Groothuis
Julius Wolff Institute, Charite Universitatsmedizin, Berlin, Germany
Bone 47:438-44. 2010..In conclusion, the paracrine pro-angiogenic capacity of early human haematomas is enhanced by mechanical stimulation. This effect lasts even after removing the mechanical stimulus and appears to be VEGFR2-dependent... - Functional comparison of chronological and in vitro aging: differential role of the cytoskeleton and mitochondria in mesenchymal stromal cellsSven Geisler
Julius Wolff Institute, Charite Universitatsmedizin Berlin, Berlin, Germany
PLoS ONE 7:e52700. 2012..Based on specific differences observed between the impact of chronological and in vitro MSC aging we conclude that both are distinct processes... - Influence of age and mechanical stability on bone defect healing: age reverses mechanical effectsPatrick Strube
Center for Musculoskeletal Surgery Berlin, Charite Universitatsmedizin, Berlin, Germany
Bone 42:758-64. 2008..Optimization of mechanics alone seems to be not sufficient. The underlying mechanisms and causes of the age-related influences and their clinical counterparts need to be further investigated... - Expression levels of the putative zinc transporter LIV-1 are associated with a better outcome of breast cancer patientsGrit Kasper
Center for Musculoskeletal Surgery, Charite University Medicine Berlin, Berlin, Germany
Int J Cancer 117:961-73. 2005..Furthermore, our study presents a revised cDNA sequence of LIV-1 and demonstrates the localization of endogenous LIV-1 in the endoplasmic reticulum... - The human LAPTM4b transcript is upregulated in various types of solid tumours and seems to play a dual functional role during tumour progressionGrit Kasper
metaGen Pharmaceuticals GmbH i L, Oudenarderstr 16, 13347 Berlin, Germany
Cancer Lett 224:93-103. 2005.... - Simulation of cell differentiation in fracture healing: mechanically loaded composite scaffolds in a novel bioreactor systemGeorg Matziolis
Center for Musculoskeletal Surgery, , Free and Humboldt-University of Berlin, Germany
Tissue Eng 12:201-8. 2006..It could serve as an in vitro model for the examination of mechanical and pharmacological influences during the early phase of bone healing on a cellular level...