Grit Kasper

Summary

Affiliation: Humboldt University
Country: Germany

Publications

  1. ncbi request reprint Mesenchymal stem cells regulate angiogenesis according to their mechanical environment
    Grit Kasper
    Musculoskeletal Research Center Berlin, Charite Universitatsmedizin Berlin, Augustenburger Platz, 113353 Berlin, Germany
    Stem Cells 25:903-10. 2007
  2. pmc Stromelysin-3 over-expression enhances tumourigenesis in MCF-7 and MDA-MB-231 breast cancer cell lines: involvement of the IGF-1 signalling pathway
    Grit Kasper
    Musculoskeletal Research Center Berlin, Charite Universitatsmedizin Berlin, Berlin, Germany
    BMC Cancer 7:12. 2007
  3. ncbi request reprint Matrix metalloprotease activity is an essential link between mechanical stimulus and mesenchymal stem cell behavior
    Grit Kasper
    Musculoskeletal Research Center Berlin, Charite Universitatsmedizin Berlin, Augustenburger Platz 1, Berlin, Germany
    Stem Cells 25:1985-94. 2007
  4. doi request reprint Modulation of matrix metalloprotease-2 levels by mechanical loading of three-dimensional mesenchymal stem cell constructs: impact on in vitro tube formation
    Juliane D Glaeser
    Julius Wolff Institute and Center for Musculoskeletal Surgery, Charite Universitatsmedizin, Berlin, Germany
    Tissue Eng Part A 16:3139-48. 2010
  5. pmc Functional comparison of chronological and in vitro aging: differential role of the cytoskeleton and mitochondria in mesenchymal stromal cells
    Sven Geisler
    Julius Wolff Institute, Charite Universitatsmedizin Berlin, Berlin, Germany
    PLoS ONE 7:e52700. 2012
  6. doi request reprint Toward biomimetic materials in bone regeneration: functional behavior of mesenchymal stem cells on a broad spectrum of extracellular matrix components
    Andrea Ode
    Julius Wolff Institute, Charite Universitatsmedizin Berlin, Berlin, Germany
    J Biomed Mater Res A 95:1114-24. 2010
  7. doi request reprint Sex-specific compromised bone healing in female rats might be associated with a decrease in mesenchymal stem cell quantity
    Patrick Strube
    Center for Musculoskeletal Surgery and Julius Wolff Institute Berlin, Charite University Medicine Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
    Bone 45:1065-72. 2009
  8. doi request reprint Insights into mesenchymal stem cell aging: involvement of antioxidant defense and actin cytoskeleton
    Grit Kasper
    Julius Wolff Institute and Center for Musculoskeletal Surgery Berlin, Charite Universitatsmedizin Berlin, Berlin, Germany
    Stem Cells 27:1288-97. 2009
  9. doi request reprint Cyclic strain disrupts endothelial network formation on Matrigel
    Cameron J Wilson
    Julius Wolff Institut and Center for Musculoskeletal Surgery, Charite Universitatsmedizin, Berlin, Germany
    Microvasc Res 78:358-63. 2009
  10. doi request reprint Mechanical stimulation of the pro-angiogenic capacity of human fracture haematoma: involvement of VEGF mechano-regulation
    Aline Groothuis
    Julius Wolff Institute, Charite Universitatsmedizin, Berlin, Germany
    Bone 47:438-44. 2010

Collaborators

Detail Information

Publications15

  1. ncbi request reprint Mesenchymal stem cells regulate angiogenesis according to their mechanical environment
    Grit Kasper
    Musculoskeletal Research Center Berlin, Charite Universitatsmedizin Berlin, Augustenburger Platz, 113353 Berlin, Germany
    Stem Cells 25:903-10. 2007
    ..The underlying mechanism appears to be dependent on the FGFR and VEGFR signaling cascades and might be mediated by an additional cross-talk with other pathways...
  2. pmc Stromelysin-3 over-expression enhances tumourigenesis in MCF-7 and MDA-MB-231 breast cancer cell lines: involvement of the IGF-1 signalling pathway
    Grit Kasper
    Musculoskeletal Research Center Berlin, Charite Universitatsmedizin Berlin, Berlin, Germany
    BMC Cancer 7:12. 2007
    ..Due to its known effect in promoting tumour formation, but its impeding effect on metastasis, a dual role of ST-3 in tumour progression, depending on the cellular grade of dedifferentiation, was hypothesized...
  3. ncbi request reprint Matrix metalloprotease activity is an essential link between mechanical stimulus and mesenchymal stem cell behavior
    Grit Kasper
    Musculoskeletal Research Center Berlin, Charite Universitatsmedizin Berlin, Augustenburger Platz 1, Berlin, Germany
    Stem Cells 25:1985-94. 2007
    ..Thus, MMP/TIMP balance seems to play an essential role in transferring mechanical signals into MSC function. Disclosure of potential conflicts of interest is found at the end of this article...
  4. doi request reprint Modulation of matrix metalloprotease-2 levels by mechanical loading of three-dimensional mesenchymal stem cell constructs: impact on in vitro tube formation
    Juliane D Glaeser
    Julius Wolff Institute and Center for Musculoskeletal Surgery, Charite Universitatsmedizin, Berlin, Germany
    Tissue Eng Part A 16:3139-48. 2010
    ..Thus, an application of these loading parameters could augment vascularization of tissue-engineered constructs based on the described MMP-2-dependent mechanism...
  5. pmc Functional comparison of chronological and in vitro aging: differential role of the cytoskeleton and mitochondria in mesenchymal stromal cells
    Sven Geisler
    Julius Wolff Institute, Charite Universitatsmedizin Berlin, Berlin, Germany
    PLoS ONE 7:e52700. 2012
    ..Based on specific differences observed between the impact of chronological and in vitro MSC aging we conclude that both are distinct processes...
  6. doi request reprint Toward biomimetic materials in bone regeneration: functional behavior of mesenchymal stem cells on a broad spectrum of extracellular matrix components
    Andrea Ode
    Julius Wolff Institute, Charite Universitatsmedizin Berlin, Berlin, Germany
    J Biomed Mater Res A 95:1114-24. 2010
    ..Finally, on this basis, peptide sequences are reported for the potential stimulation of MSC functions. Based on the results of this study, ECM component coatings could be designed to specifically guide cell functions...
  7. doi request reprint Sex-specific compromised bone healing in female rats might be associated with a decrease in mesenchymal stem cell quantity
    Patrick Strube
    Center for Musculoskeletal Surgery and Julius Wolff Institute Berlin, Charite University Medicine Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
    Bone 45:1065-72. 2009
    ..Because mesenchymal stem cells (MSCs) are postulated to regulate tissue regeneration and give rise to essential differentiated cell types, they may contribute to sex-specific differences in bone healing outcomes...
  8. doi request reprint Insights into mesenchymal stem cell aging: involvement of antioxidant defense and actin cytoskeleton
    Grit Kasper
    Julius Wolff Institute and Center for Musculoskeletal Surgery Berlin, Charite Universitatsmedizin Berlin, Berlin, Germany
    Stem Cells 27:1288-97. 2009
    ....
  9. doi request reprint Cyclic strain disrupts endothelial network formation on Matrigel
    Cameron J Wilson
    Julius Wolff Institut and Center for Musculoskeletal Surgery, Charite Universitatsmedizin, Berlin, Germany
    Microvasc Res 78:358-63. 2009
    ..Most importantly, the results indicate that the straining of endothelial cells and their assembly into vascular-like structures must be studied simultaneously to adequately characterise the mechanical influence on vessel formation...
  10. doi request reprint Mechanical stimulation of the pro-angiogenic capacity of human fracture haematoma: involvement of VEGF mechano-regulation
    Aline Groothuis
    Julius Wolff Institute, Charite Universitatsmedizin, Berlin, Germany
    Bone 47:438-44. 2010
    ..In conclusion, the paracrine pro-angiogenic capacity of early human haematomas is enhanced by mechanical stimulation. This effect lasts even after removing the mechanical stimulus and appears to be VEGFR2-dependent...
  11. doi request reprint Crosstalk between immune cells and mesenchymal stromal cells in a 3D bioreactor system
    Martina Seifert
    Institute of Medical Immunology, Charité Medical University Berlin, Berlin, Germany
    Int J Artif Organs 35:986-95. 2012
    ....
  12. doi request reprint Influence of age and mechanical stability on bone defect healing: age reverses mechanical effects
    Patrick Strube
    Center for Musculoskeletal Surgery Berlin, Charite Universitatsmedizin, Berlin, Germany
    Bone 42:758-64. 2008
    ..Optimization of mechanics alone seems to be not sufficient. The underlying mechanisms and causes of the age-related influences and their clinical counterparts need to be further investigated...
  13. ncbi request reprint Expression levels of the putative zinc transporter LIV-1 are associated with a better outcome of breast cancer patients
    Grit Kasper
    Center for Musculoskeletal Surgery, Charite University Medicine Berlin, Berlin, Germany
    Int J Cancer 117:961-73. 2005
    ..Furthermore, our study presents a revised cDNA sequence of LIV-1 and demonstrates the localization of endogenous LIV-1 in the endoplasmic reticulum...
  14. ncbi request reprint The human LAPTM4b transcript is upregulated in various types of solid tumours and seems to play a dual functional role during tumour progression
    Grit Kasper
    metaGen Pharmaceuticals GmbH i L, Oudenarderstr 16, 13347 Berlin, Germany
    Cancer Lett 224:93-103. 2005
    ....
  15. ncbi request reprint Simulation of cell differentiation in fracture healing: mechanically loaded composite scaffolds in a novel bioreactor system
    Georg Matziolis
    Center for Musculoskeletal Surgery, Charite University Medicine Berlin, Free and Humboldt University of Berlin, Germany
    Tissue Eng 12:201-8. 2006
    ..It could serve as an in vitro model for the examination of mechanical and pharmacological influences during the early phase of bone healing on a cellular level...