Jens Jordan

Summary

Affiliation: Humboldt University
Country: Germany

Publications

  1. ncbi request reprint Influences of norepinephrine transporter function on the distribution of sympathetic activity in humans
    Antje F Mayer
    Franz Volhard Clinical Research Center, Medical Faculty of the Charite, Max Delbrueck Centrum, and HELIOS Klinikum, Berlin, Germany
    Hypertension 48:120-6. 2006
  2. ncbi request reprint European Society of Hypertension Working Group on Obesity: background, aims and perspectives
    Jens Jordan
    Franz Volhard Clinical Research Center and Department of Nephrology, Helios Klinikum Berlin and Medical Faculty of the Charité, Berlin, Germany
    J Hypertens 25:897-900. 2007
  3. ncbi request reprint Direct Renin inhibition with aliskiren in obese patients with arterial hypertension
    Jens Jordan
    Franz Volhard Clinical Research Center, Medical Faculty of the Charité and HELIOS Klinikum, Berlin, Germany
    Hypertension 49:1047-55. 2007
  4. ncbi request reprint Stimulation of cholecystokinin-A receptors with GI181771X does not cause weight loss in overweight or obese patients
    J Jordan
    Franz Volhard Clinical Research Center, Helios Klinikum and Medical Faculty of the Charité, Berlin, Germany
    Clin Pharmacol Ther 83:281-7. 2008
  5. pmc Beta-adrenergic and atrial natriuretic peptide interactions on human cardiovascular and metabolic regulation
    Andreas L Birkenfeld
    Franz Volhard Clinical Research Center, Haus 129, Charite Campus Buch, Wiltbergstr 50, 13125 Berlin, Germany
    J Clin Endocrinol Metab 91:5069-75. 2006
  6. pmc Atrial natriuretic peptide induces postprandial lipid oxidation in humans
    Andreas L Birkenfeld
    Experimental and Clinical Research Center, Charité and HELIOS Klinikum, Berlin, Germany
    Diabetes 57:3199-204. 2008
  7. doi request reprint Norepinephrine transporter inhibition alters the hemodynamic response to hypergravitation
    Sebastian Strempel
    Franz Volhard Clinical Research Center, Medical University Charité, Campus Buch, Wiltbergstrasse 50, Haus 129, Berlin, Germany
    J Appl Physiol (1985) 104:756-60. 2008
  8. doi request reprint Myocardial steatosis, cardiac remodelling and fitness in insulin-sensitive and insulin-resistant obese women
    Wolfgang Utz
    Working Group Cardiac MR Medical Faculty of the Charité Campus Buch and HELIOS Klinikum Berlin Buch, Berlin, Germany
    Heart 97:1585-9. 2011
  9. pmc Peripheral endocannabinoid system activity in patients treated with sibutramine
    Stefan Engeli
    Franz Volhard Clinical Research Center, Medical Faculty of the Charité and HELIOS Klinikum, Berlin, Germany
    Obesity (Silver Spring) 16:1135-7. 2008
  10. ncbi request reprint Paradoxical effect of sibutramine on autonomic cardiovascular regulation in obese hypertensive patients--sibutramine and blood pressure
    Andreas L Birkenfeld
    Franz Volhard Clinical Research Center, Medical Faculty of the Charité and HELIOS Klinikum, Berlin, Germany
    Clin Auton Res 15:200-6. 2005

Collaborators

Detail Information

Publications105 found, 100 shown here

  1. ncbi request reprint Influences of norepinephrine transporter function on the distribution of sympathetic activity in humans
    Antje F Mayer
    Franz Volhard Clinical Research Center, Medical Faculty of the Charite, Max Delbrueck Centrum, and HELIOS Klinikum, Berlin, Germany
    Hypertension 48:120-6. 2006
    ..All of these changes are physiologically relevant because they lead to corresponding changes in organ function...
  2. ncbi request reprint European Society of Hypertension Working Group on Obesity: background, aims and perspectives
    Jens Jordan
    Franz Volhard Clinical Research Center and Department of Nephrology, Helios Klinikum Berlin and Medical Faculty of the Charité, Berlin, Germany
    J Hypertens 25:897-900. 2007
  3. ncbi request reprint Direct Renin inhibition with aliskiren in obese patients with arterial hypertension
    Jens Jordan
    Franz Volhard Clinical Research Center, Medical Faculty of the Charité and HELIOS Klinikum, Berlin, Germany
    Hypertension 49:1047-55. 2007
    ..In conclusion, combination treatment with aliskiren is a highly effective and well-tolerated therapeutic option for obese patients with hypertension who fail to achieve blood pressure control with first-line thiazide diuretic treatment...
  4. ncbi request reprint Stimulation of cholecystokinin-A receptors with GI181771X does not cause weight loss in overweight or obese patients
    J Jordan
    Franz Volhard Clinical Research Center, Helios Klinikum and Medical Faculty of the Charité, Berlin, Germany
    Clin Pharmacol Ther 83:281-7. 2008
    ..Gastrointestinal side effects were more common with GI181771X than with placebo treatment, whereas hepatobiliary or pancreatic abnormalities did not occur. CCK-A by itself does not have a central role in long-term energy balance...
  5. pmc Beta-adrenergic and atrial natriuretic peptide interactions on human cardiovascular and metabolic regulation
    Andreas L Birkenfeld
    Franz Volhard Clinical Research Center, Haus 129, Charite Campus Buch, Wiltbergstr 50, 13125 Berlin, Germany
    J Clin Endocrinol Metab 91:5069-75. 2006
    ..Atrial natriuretic peptide (ANP) has well-known cardiovascular effects and modifies lipid and carbohydrate metabolism in humans...
  6. pmc Atrial natriuretic peptide induces postprandial lipid oxidation in humans
    Andreas L Birkenfeld
    Experimental and Clinical Research Center, Charité and HELIOS Klinikum, Berlin, Germany
    Diabetes 57:3199-204. 2008
    ..We hypothesized that ANP increases postprandial free fatty acid (FFA) availability and energy expenditure while decreasing arterial blood pressure...
  7. doi request reprint Norepinephrine transporter inhibition alters the hemodynamic response to hypergravitation
    Sebastian Strempel
    Franz Volhard Clinical Research Center, Medical University Charité, Campus Buch, Wiltbergstrasse 50, Haus 129, Berlin, Germany
    J Appl Physiol (1985) 104:756-60. 2008
    ..Redistribution of sympathetic activity to the heart or changes in baroreflex responses could explain the excessive tachycardia that we observed...
  8. doi request reprint Myocardial steatosis, cardiac remodelling and fitness in insulin-sensitive and insulin-resistant obese women
    Wolfgang Utz
    Working Group Cardiac MR Medical Faculty of the Charité Campus Buch and HELIOS Klinikum Berlin Buch, Berlin, Germany
    Heart 97:1585-9. 2011
    ..Lipotoxic injury from altered myocardial metabolism may be causative. Whether such association also exists in obese, non-diabetic women is unknown...
  9. pmc Peripheral endocannabinoid system activity in patients treated with sibutramine
    Stefan Engeli
    Franz Volhard Clinical Research Center, Medical Faculty of the Charité and HELIOS Klinikum, Berlin, Germany
    Obesity (Silver Spring) 16:1135-7. 2008
    ..Weight loss interventions may influence obesity-associated risk indirectly through modulation of the peripheral ECS. We investigated the effect of acute and chronic treatment with sibutramine on components of the peripheral ECS...
  10. ncbi request reprint Paradoxical effect of sibutramine on autonomic cardiovascular regulation in obese hypertensive patients--sibutramine and blood pressure
    Andreas L Birkenfeld
    Franz Volhard Clinical Research Center, Medical Faculty of the Charité and HELIOS Klinikum, Berlin, Germany
    Clin Auton Res 15:200-6. 2005
    ..This notion has not been tested in overweight and obese patients...
  11. ncbi request reprint Dissociation between adipose nitric oxide synthase expression and tissue metabolism
    Stefan Engeli
    Franz Volhard Clinical Research Center, Charite Campus Buch, Wiltbergstrasse 50, 13125 Berlin, Germany
    J Clin Endocrinol Metab 92:2706-11. 2007
    ..Nitric oxide synthase (NOS) expression in adipose tissue is increased in obese subjects. The functional relevance is not known...
  12. ncbi request reprint Baroreflex buffering and susceptibility to vasoactive drugs
    Jens Jordan
    Franz Volhard Clinical Research Center and HELIOS Klinikum, Medical Faculty of the Charite, Humboldt University, Berlin, Germany
    Circulation 105:1459-64. 2002
    ..Differences in baroreflex function affect the responsiveness to vasoactive medications, particularly baroreflex buffering of blood pressure; however, the magnitude is not known...
  13. ncbi request reprint Influence of St John's wort on catecholamine turnover and cardiovascular regulation in humans
    Christoph Schroeder
    Franz Volhard Clinical Research Center, Charité Campus Buch and Helio Klinikum, Berlin, Germany
    Clin Pharmacol Ther 76:480-9. 2004
    ..St John's wort (Hypericum perforatum) is a popular over-the-counter antidepressant. Its antidepressive effect has been attributed in part to inhibition of monoamine transporters and monoamine oxidase, on the basis of in vitro studies...
  14. ncbi request reprint Cardiovascular autonomic regulation in Non-Obese Diabetic (NOD) mice
    Volkmar Gross
    Max Delbruck Center for Molecular Medicine, Berlin, Germany
    Auton Neurosci 138:108-13. 2008
    ..In conclusion the use of diabetic NOD mice as a functional model for human diabetes may be questioned...
  15. ncbi request reprint Phenotypical evidence for a gender difference in cardiac norepinephrine transporter function
    Christoph Schroeder
    Franz Volhard Clinical Research Center, Haus 129, Medical Faculty of the Charité Campus Buch, Wiltbergstrasse 50, 13125 Berlin, Germany
    Am J Physiol Regul Integr Comp Physiol 286:R851-6. 2004
    ..Our observations suggest that the NET contribution to cardiac norepinephrine turnover may be decreased in women. The gender difference in NET function may not be expressed in tissues that are less NET dependent than the heart...
  16. doi request reprint Moderate dietary weight loss reduces myocardial steatosis in obese and overweight women
    Wolfgang Utz
    Working Group Cardiac MR, Medical Faculty of the Charité Campus Buch and HELIOS Klinikum Berlin Buch, Berlin, Germany
    Int J Cardiol 167:905-9. 2013
    ..Previous studies suggest that MTG could be mobilized through lifestyle interventions. We assessed influences of moderate dietary weight loss in non diabetic obese and overweight women on MTG content and cardiac function...
  17. ncbi request reprint Influences of AT1 receptor blockade on tissue metabolism in obese men
    Michael Boschmann
    Franz Volhard Clinical Research Center, Haus 129, Charite Campus Buch, Wiltbergstr 50, 13125 Berlin, Germany
    Am J Physiol Regul Integr Comp Physiol 290:R219-23. 2006
    ..Endogeneous ANG II may slightly increase adipose tissue lipolysis. The mechanism may promote the redistribution of triglycerides from adipose tissue toward other organs...
  18. ncbi request reprint Alpha-2 adrenergic transmission and human baroreflex regulation
    Jens Tank
    Department of Nephrology and Hypertension, Franz Volhard Clinic, Medical Faculty of the Charité and HELIOS Klinikum, Berlin, Germany
    Hypertension 43:1035-41. 2004
    ..alpha-2 Adrenoceptor stimulation greatly augments baroreflex-mediated bradycardia, most likely by parasympathetic activation...
  19. ncbi request reprint Yohimbine attenuates baroreflex-mediated bradycardia in humans
    Jens Tank
    Franz Volhard Clinical Research Center, Medical Faculty of the Charité and HELIOS Klinikum, Berlin, Germany
    Hypertension 50:899-903. 2007
    ..In contrast, yohimbine did not alter the sympathetic baroreflex curve. Yohimbine selectively attenuates baroreflex heart rate control in normotensive young men possibly through parasympathetic mechanisms...
  20. doi request reprint Orthostatic tolerance is difficult to predict in recurrent syncope patients
    Christoph Schroeder
    Experimental Clinical Research Center, Max Delbrueck Centrum for Molecular Medicine, Medical University Charité, Lindenberger Weg 80, Berlin, Germany
    Clin Auton Res 21:37-45. 2011
    ..In addition, we tested whether orthostatic tolerance is related to syncope frequency in real life...
  21. ncbi request reprint Regulator of G protein signalling 2 ameliorates angiotensin II-induced hypertension in mice
    Hantz C Hercule
    Max Delbruck Center for Molecular Medicine, Berlin, Germany
    Exp Physiol 92:1014-22. 2007
    ..Our findings suggest that RGS2 deletion promotes Ang II-dependent hypertension primarily through an increase of myogenic tone and vasoreactivity, probably by sensitization of AT(1) receptors...
  22. doi request reprint Hormonal influences on cardiovascular norepinephrine transporter responses in healthy women
    Iryna Moldovanova
    Medical University Charité, Franz Volhard Clinical Research Center, Helios Klinikum Berlin and Max Delbrück Center for Molecular Medicine, Berlin, Germany
    Hypertension 51:1203-9. 2008
    ..The phenomenon may be explained by an effect of female sex hormones on norepinephrine transporter function, on compensatory cardiovascular responses, or both...
  23. ncbi request reprint Influence of sibutramine treatment on sympathetic vasomotor tone in obese subjects
    Karsten Heusser
    Franz Volhard Clinical Research Center, Medical Faculty of the Charité and HELIOS Klinkum, Berlin, Germany
    Clin Pharmacol Ther 79:500-8. 2006
    ..Direct measurements of muscle sympathetic nerve activity (MSNA) in sibutramine-treated patients have not been conducted...
  24. ncbi request reprint Hemodynamic and metabolic responses to valsartan and atenolol in obese hypertensive patients
    Jens Jordan
    Franz Volhard Clinical Research Center, Medical Faculty of the Charité and HELIOS Klinikum, Berlin, Germany
    J Hypertens 23:2313-8. 2005
    ..Treatment recommendations for lean hypertensives may not be simply extrapolated to obese hypertensive persons...
  25. ncbi request reprint Water drinking acutely improves orthostatic tolerance in healthy subjects
    Christoph Schroeder
    Franz Volhard Clinical Research Center, Medical Faculty of the Charite, Humboldt University, Berlin, Germany
    Circulation 106:2806-11. 2002
    ..In patients with severe autonomic dysfunction, water drinking elicits an acute pressor response and improves orthostatic hypotension. We tested the hypothesis that water drinking also improves orthostatic tolerance in healthy subjects...
  26. doi request reprint Circulating endocannabinoid concentrations during orthostatic stress
    Christoph Schroeder
    Franz Volhard Clinical Research Center, Helios Klinikum Berlin and Max Delbrück Center for Molecular Medicine, Berlin, Germany
    Clin Auton Res 19:343-6. 2009
    ..In animals, the endocannabinoid system is activated during hemodynamic insults and restrains blood pressure in part through sympathetic inhibition...
  27. ncbi request reprint Catechol-o-methyltransferase and blood pressure in humans
    Jens Jordan
    Franz Volhard Clinical Research Center and Helios Klinikum Berlin, Medical Faculty of the Charite, Humboldt University, Berlin, Germany
    Circulation 106:460-5. 2002
    ..Whether catechol-O-methyltransferase (COMT), the enzyme that metabolizes extraneuronal norepinephrine, contributes to blood pressure regulation in humans is unknown...
  28. doi request reprint Role of the multidomain protein spinophilin in blood pressure and cardiac function regulation
    Andrey C da Costa-Goncalves
    Max Delbruck Center for Molecular Medicine, Berlin, Germany
    Hypertension 52:702-7. 2008
    ..The elevated blood pressure in SPL(-/-) mice was associated with attenuated baroreflex sensitivity and decreased parasympathetic activity. Our study is the first to show a role for the spinophilin gene in blood pressure regulation...
  29. ncbi request reprint Clonidine improves spontaneous baroreflex sensitivity in conscious mice through parasympathetic activation
    Jens Tank
    Department of Nephrology and Hypertension, Franz Volhard Clinic, Medical Faculty of the Charité and HELIOS Klinikum, Berlin, Germany
    Hypertension 43:1042-7. 2004
    ..The effect of clonidine on baroreflex HR regulation is mediated by the parasympathetic nervous system. These murine data fit well with recent human observations regarding parasympathetic activation via alpha-2 adrenoceptors...
  30. ncbi request reprint Baroreflex regulation of heart rate and sympathetic vasomotor tone in women and men
    Jens Tank
    Franz Volhard Clinical Research Center, Medical Faculty, Charité and HELIOS Klinikum, Berlin, Germany
    Hypertension 45:1159-64. 2005
    ..06% for burst rate, 0.4% for burst incidence, and 0.01% for burst area. In women, the MSNA baroreflex curve may be shifted to slightly lower blood pressure such that at a given blood pressure MSNA tends to be lower...
  31. ncbi request reprint Norepinephrine transporter inhibition prevents tilt-induced pre-syncope
    Christoph Schroeder
    Franz Volhard Clinical Research Center, Medical Faculty of the Charité and HELIOS Klinikum, Berlin, Germany
    J Am Coll Cardiol 48:516-22. 2006
    ..We tested the hypothesis that pharmacological norepinephrine reuptake transporter (NET) inhibition delays the onset of head-up tilt-induced presyncope in healthy subjects...
  32. doi request reprint Left ventricular mass and function with reduced-fat or reduced-carbohydrate hypocaloric diets in overweight and obese subjects
    Sven Haufe
    Franz Volhard Clinical Research Center at the Experimental and Clinical Research Center, Charité University Medical Faculty and Max Delbrück Center for Molecular Medicine, Berlin, Germany
    Hypertension 59:70-5. 2012
    ..However, n-3 polyunsaturated fatty acid ingestion may have an independent beneficial effect on left ventricular mass...
  33. pmc Cardiorespiratory fitness and insulin sensitivity in overweight or obese subjects may be linked through intrahepatic lipid content
    Sven Haufe
    Franz Volhard Clinical Research Center at Experimental and Clinical Research Center, Charité University Medical School and Max Delbrück Center for Molecular Medicine, Berlin, Germany
    Diabetes 59:1640-7. 2010
    ..Given the close relationship between intrahepatic lipid content (IHL) and insulin sensitivity, we hypothesized that the direct relationship between fitness and insulin sensitivity may be explained by IHL...
  34. ncbi request reprint Sympathetic vasomotor tone determines blood pressure response to long-term sibutramine treatment
    Karsten Heusser
    Franz Volhard Clinical Research Center, Medical Faculty of the Charité and HELIOS Klinikum, Berlin, Germany
    J Clin Endocrinol Metab 92:1560-3. 2007
    ..The serotonin and norepinephrine transporter inhibitor sibutramine is a widely used antiobesity drug. In acute studies, the peripheral sympathomimetic effect of sibutramine was counteracted by a central sympatholytic action...
  35. doi request reprint The Valsalva maneuver: screening for drug-induced baroreflex dysfunction
    Christoph Schroeder
    Medical University Charité, Franz Volhard Clinical Research Center, Helios Klinikum Berlin and Max Delbrück Center for Molecular Medicine, Berlin, Germany
    Clin Auton Res 19:32-8. 2009
    ..Many drugs can interfere with baroreflex mechanisms thereby impairing blood pressure control, but few have undergone sufficient testing. The state of affairs may be explained by the lack of simple and inexpensive screening tests...
  36. ncbi request reprint Pressor effect of water drinking in tetraplegic patients may be a spinal reflex
    Jens Tank
    HELIOS Kliniken Berlin, Franz Volhard Cardiovascular Research Center, Medical Faculty of the Charite, Humboldt University, Berlin, Germany
    Hypertension 41:1234-9. 2003
    ..This observation might suggest that water drinking activates postganglionic sympathetic neurons either directly or through a spinal reflex mechanism...
  37. doi request reprint Spinophilin regulates central angiotensin II-mediated effect on blood pressure
    Andrey C da Costa Goncalves
    Leibniz Institute for Molecular Pharmacology, Berlin, Germany
    J Mol Med (Berl) 89:1219-29. 2011
    ..SPL is a hitherto unrecognized molecule with regard to central blood pressure control and may pave the way to novel strategies for the treatment of hypertension...
  38. doi request reprint Influences of normobaric hypoxia training on physical fitness and metabolic risk markers in overweight to obese subjects
    Susanne Wiesner
    Franz Volhard Clinical Research Center at the Experimental and Clinical Research Center, Medical Faculty of the Charite, Berlin, Germany
    Obesity (Silver Spring) 18:116-20. 2010
    ..The fact that workload and, therefore, mechanic strain can be reduced in hypoxia could be particularly beneficial in obese patients with orthopedic comorbidities...
  39. ncbi request reprint Lipid mobilization with physiological atrial natriuretic peptide concentrations in humans
    Andreas L Birkenfeld
    Franz Volhard Clinical Research Center, Haus 129, Charite Campus Buch, Wiltbergstrasse 50, 13125 Berlin, Germany
    J Clin Endocrinol Metab 90:3622-8. 2005
    ..Atrial natriuretic peptide (ANP) in pharmacological concentrations stimulates lipid mobilization in humans...
  40. ncbi request reprint Dipeptidyl-peptidase-IV inhibition augments postprandial lipid mobilization and oxidation in type 2 diabetic patients
    Michael Boschmann
    Franz Volhard Clinical Research Center, Helios Klinikum and Medical Faculty of the Charité, D 13125 Berlin, Germany
    J Clin Endocrinol Metab 94:846-52. 2009
    ..Dipeptidyl-peptidase-IV (DPP-4) inhibition increases endogenous GLP-1 activity, resulting in improved glycemic control in patients with type 2 diabetes mellitus. The metabolic response may be explained in part by extrapancreatic mechanisms...
  41. doi request reprint Aliskiren penetrates adipose and skeletal muscle tissue and reduces renin-angiotensin system activity in obese hypertensive patients
    Michael Boschmann
    Franz Volhard Clinical Research Center, Charite, Berlin, Germany
    J Hypertens 30:561-6. 2012
    ..Therefore, we investigated whether aliskiren attains tissue concentrations sufficient to inhibit local renin-angiotensin system (RAS) activity in patients...
  42. ncbi request reprint Angiotensin type 1 receptor antagonists induce human in-vitro adipogenesis through peroxisome proliferator-activated receptor-gamma activation
    Jurgen Janke
    Medical Faculty of the Charite, Franz Volhard Clinic, HELIOS Klinikum Berlin, Berlin, Germany
    J Hypertens 24:1809-16. 2006
    ..In clonal animal cells, certain angiotensin receptor blockers (ARB) activate the peroxisome proliferator-activated receptor-gamma (PPARgamma). The aim of this work was to validate that observation in human cells and humans...
  43. ncbi request reprint Influences of levodopa on adipose tissue and skeletal muscle metabolism in patients with idiopathic Parkinson's disease
    Frauke Adams
    Experimental and Clinical Research Center, A Cooperation with Max Delbrueck Center for Molecular Medicine, Charite Campus Buch, and HELIOS Klinikum, Berlin, Germany
    Eur J Clin Pharmacol 64:863-70. 2008
    ..We assessed systemic and local metabolic responses to levodopa/benserazide in patients with idiopathic Parkinson's disease...
  44. ncbi request reprint Paradoxical effect of sibutramine on autonomic cardiovascular regulation
    Andreas L Birkenfeld
    Franz Volhard Clinical Research Center, Medical Faculty of the Charite, Humboldt University, Berlin, Germany
    Circulation 106:2459-65. 2002
    ..Norepinephrine reuptake inhibition with sibutramine conceivably could exacerbate arterial hypertension and promote cardiovascular disease...
  45. ncbi request reprint Baroreflex failure
    Karsten Heusser
    Franz Volhard Clinical Research Center, Medical Faculty of the Charité and HELIOS Klinikum, Berlin, Germany
    Hypertension 45:834-9. 2005
    ..Both had muscle sympathetic nerve activity that was increased even while resting. Treating these patients was a stochastic challenge. The therapy is frequently based on medicines that are no longer commonly prescribed...
  46. doi request reprint Randomized comparison of reduced fat and reduced carbohydrate hypocaloric diets on intrahepatic fat in overweight and obese human subjects
    Sven Haufe
    Max Delbruck Center for Molecular Medicine, Berlin, Germany
    Hepatology 53:1504-14. 2011
    ..56%) irrespective of diet composition. In contrast, changes in visceral fat mass and insulin sensitivity were similar between subgroups, with low and high baseline intrahepatic lipids...
  47. ncbi request reprint Adipose tissue metabolism and CD11b expression on monocytes in obese hypertensives
    Michael Boschmann
    Franz Volhard Clinical Research Center, Charite Campus Buch, HELIOS Klinikum, Berlin, Germany
    Hypertension 46:130-6. 2005
    ..These findings may be explained in part by monocyte/macrophage infiltration of adipose tissue, which appears to interfere with insulin responsiveness...
  48. ncbi request reprint Heterogeneity of autonomic regulation in hypertension and neurovascular contact
    Jens Jordan
    HELIOS Klinikum Berlin, Franz Volhard Clinic and Clinical Research Center, Medical Faculty of the Charite, Humboldt University, Berlin, Germany
    J Hypertens 20:701-6. 2002
    ..We tested the hypothesis that similar abnormalities are present in patients with essential hypertension who have NVC...
  49. pmc Atrial natriuretic peptide and adiponectin interactions in man
    Andreas L Birkenfeld
    Department of Endocrinology, Diabetes and Nutrition, Center for Cardiovascular Research CCR, Charite University School of Medicine, Berlin, Germany
    PLoS ONE 7:e43238. 2012
    ..Our study could have implications for the physiological regulation of adiponectin and for disease states associated with altered natriuretic peptide availability...
  50. doi request reprint Influences of normobaric hypoxia training on metabolic risk markers in human subjects
    Sven Haufe
    Franz Volhard Clinical Research Center, Medical Faculty of the Charite, Berlin, Germany
    Med Sci Sports Exerc 40:1939-44. 2008
    ..We hypothesized that training under hypoxia results in similar or even greater metabolic improvement compared with exercise under normoxia at a lower workload...
  51. pmc Activation of the peripheral endocannabinoid system in human obesity
    Stefan Engeli
    Franz Volhard Clinical Research Center, Charite Campus Buch, 13125 Berlin, Germany
    Diabetes 54:2838-43. 2005
    ..Our findings support the presence of a peripheral endocannabinoid system that is upregulated in human obesity...
  52. ncbi request reprint Blood oxygen level-dependent MRI of tissue oxygenation: relation to endothelium-dependent and endothelium-independent blood flow changes
    Wolfgang Utz
    Medical Faculty of the Charite, Franz Volhard Klinik HELIOS Klinikum Berlin at the Max Delbrück Center for Molecular Medicine, Berlin, Germany
    Arterioscler Thromb Vasc Biol 25:1408-13. 2005
    ..Muscle blood oxygen level-dependent MRI (BOLD MRI) provides data largely dependent on hemoglobin (Hb) oxygenation. We used BOLD MRI to assess endothelium-dependent signal intensity (SI) changes...
  53. ncbi request reprint Heritability of left ventricular and papillary muscle heart size: a twin study with cardiac magnetic resonance imaging
    Christoph A Busjahn
    Medical Faculty of the Charite, Franz Volhard Clinic, HELIOS Klinikum Berlin, Experimental and Clinical Research Center and Max Delbrueck Center for Molecular Medicine, Berlin, Germany
    Eur Heart J 30:1643-7. 2009
    ..We performed a twin study relying on CMR, focusing on left ventricular (LV) mass and papillary muscle, since there are no genetic reports on this structure...
  54. ncbi request reprint Hemodynamic and metabolic responses to interstitial angiotensin II in normal weight and obese men
    Michael Boschmann
    Franz Volhard Clinical Research Center, Charite, Universitary Medicine Berlin, Germany
    J Hypertens 24:1165-71. 2006
    ..Therefore, we hypothesized that peripheral tissues of obese subjects are hypersensitive to angiotensin (Ang) II...
  55. ncbi request reprint Riluzole and blood pressure in multiple system atrophy
    Axel Lipp
    Department of Neurology, Medical Faculty of the Charité Humboldt University, Berlin, Germany
    Clin Auton Res 13:271-4. 2003
    ..The response is explained by a marked increase in systemic vascular resistance. We propose that decreased inhibition of efferent sympathetic neurons may contribute to the response...
  56. ncbi request reprint Heritability of free and receptor-bound leptin in normal twins
    Jens Jordan
    Franz Volhard Clinical Research Center, Medical Faculty of the Charité and HELIOS Klinikum, Berlin, Germany
    Am J Physiol Regul Integr Comp Physiol 288:R1411-6. 2005
    ..The same genes that lower bound leptin and leptin receptor concentrations may increase fat mass or vice versa...
  57. ncbi request reprint Adrenergic responsiveness of adipose tissue lipolysis in autonomic failure
    Jens Jordan
    Medical Faculty of the Charite, Franz Volhard Clinical Research Center, Helios Klinikum and Max Delbrück Center, Berlin, Germany
    Clin Auton Res 14:80-3. 2004
    ..We propose that beta-adrenoreceptor upregulation is compensated by a desensitization of post receptor mechanisms or by an upregulation of antilipolytic pathways...
  58. ncbi request reprint Influence of salt intake on renin-angiotensin and natriuretic peptide system genes in human adipose tissue
    Stefan Engeli
    Franz Volhard Clinical Research Center, Medical Faculty of the Charité and HELIOS Klinikum, Berlin, Germany
    Hypertension 48:1103-8. 2006
    ..In contrast, systemic atrial natriuretic peptide and adipose-tissue atrial natriuretic peptide respond similarly to changes in sodium intake...
  59. doi request reprint Compounds used for 'injection lipolysis' destroy adipocytes and other cells found in adipose tissue
    Jurgen Janke
    Experimental and Clinical Research Center, Charite, Universitätsmedizin Berlin Campus Buch and Max Delbrück Center for Molecular Medicine, Berlin, Germany
    Obes Facts 2:36-9. 2009
    ..As the mode of action is mostly unknown, we planned to study cellular effects of the particular drug used in Germany (Lipostabil(R))...
  60. ncbi request reprint A pilot study of chronic, low-dose epoetin-{beta} following percutaneous coronary intervention suggests safety, feasibility, and efficacy in patients with symptomatic ischaemic heart failure
    Martin W Bergmann
    Franz Volhard Clinic, Charite Campus Buch, Berlin, Germany
    Eur J Heart Fail 13:560-8. 2011
    ..Low-dose epoetin-β improved neo-angiogenesis and cardiac regeneration in experimental models of ischaemic cardiomyopathy without raising haemoglobin. No clinical study has tested this approach to date...
  61. ncbi request reprint Heritability of venous function in humans
    Marina Brinsuk
    Franz Volhard Clinical Research Center, Helios Klinikum Berlin and Medical Faculty of the Charité, Humboldt University, Berlin, Germany
    Arterioscler Thromb Vasc Biol 24:207-11. 2004
    ..Venous function contributes to the pathogenesis of thrombophlebitis, venous thrombosis, and possibly to arterial hypertension. Venous disease is presumably heritable; however, the genetic variance of venous function is unknown...
  62. ncbi request reprint Autosomal-dominant hypertension with type E brachydactyly is caused by rearrangement on the short arm of chromosome 12
    Sylvia Bahring
    Medical Faculty of the Charite, The Clinical Research Center, Franz Volhard Clinic and the Max Delbrück Center for Molecular Medicine, Berlin, Germany
    Hypertension 43:471-6. 2004
    ..Although our 3 candidate genes are no longer likely, the rearrangement we describe greatly enhances the perspectives of this project...
  63. ncbi request reprint Diagnosis and treatment of supine hypertension in autonomic failure patients with orthostatic hypotension
    Jens Jordan
    Hypotension and Syncope Unit, Clinical Research Center, Franz Volhard Clinic, Medical Faculty of the Charite, Humboldt University, Berlin, Germany
    J Clin Hypertens (Greenwich) 4:139-45. 2002
    ..During the day, avoiding the supine position is often all that is required. Short-acting vasodilators (e.g., transdermal nitroglycerin) can be used during the night...
  64. ncbi request reprint The endocannabinoid system: body weight and metabolic regulation
    Stefan Engeli
    Franz Volhard Clinical Research Center, University Clinic Charité Campus Buch, Humboldt University of Berlin, Wiltbergstrasse 50, 13125 Berlin, Germany
    Clin Cornerstone 8:S24-35. 2006
    ....
  65. pmc LMNA mutations, skeletal muscle lipid metabolism, and insulin resistance
    Michael Boschmann
    Franz Volhard Clinical Research Center at the Experimental and Clinical Research Center, University Hospital Charite Campus Buch and HELIOS Klinikum Berlin, 13125 Berlin, Germany
    J Clin Endocrinol Metab 95:1634-43. 2010
    ..The symptoms may all be explained by defective metabolism; however, metabolism at the tissue level has not been investigated...
  66. ncbi request reprint Sympathetic nerve traffic and circulating norepinephrine levels in RGS2-deficient mice
    Jens Tank
    Medical Faculty of the Charite, Franz Volhard Clinic, HELIOS Klinikum Berlin, Wiltbergstrasse 50, 13125 Berlin, Germany
    Auton Neurosci 136:52-7. 2007
    ..This observation may depend on altered coupling between electrical nerve activity and norepinephrine release and/or a changed norepinephrine uptake in RGS2-/- mice...
  67. ncbi request reprint Tyramine in the assessment of regional adrenergic function
    F Adams
    Universitary Medicine, Charite Campus Buch, Franz Volhard Clinical Research Center and HELIOS Klinikum, Berlin, Germany
    Biochem Pharmacol 72:1724-9. 2006
    ..Tyramine applied through a microdialysis probe in concentrations up to 3.5 mM can be used to assess pre- and post-synaptic mechanisms regulating lipid mobilization...
  68. ncbi request reprint Influence of Sibutramine on blood pressure: evidence from placebo-controlled trials
    J Jordan
    Franz Volhard Clinical Research Center and HELIOS Klinikum, Medical Faculty of the Charite, Humboldt University, Berlin, Germany
    Int J Obes (Lond) 29:509-16. 2005
    ..Sibutramine, a serotonin and norepinephrine transporter inhibitor, is widely used as an adjunctive obesity treatment. There have been concerns that norepinephrine reuptake inhibition with sibutramine could exacerbate arterial hypertension...
  69. ncbi request reprint Sympathetic activation due to deep brain stimulation in the region of the STN
    A Lipp
    Department of Neurology, Medical Faculty of the Charite, Berlin, Germany
    Neurology 65:774-5. 2005
  70. ncbi request reprint Increased sympathetic activation in idiopathic orthostatic intolerance: role of systemic adrenoreceptor sensitivity
    Jens Jordan
    Clinical Research Center, Franz Volhard Clinic, Charite, Berlin, Germany
    Hypertension 39:173-8. 2002
    ..Our findings suggest that the hyperadrenergic features of OI cannot be completely explained by systemic hypersensitivity of postsynaptic alpha(1)- and beta-adrenoreceptors but rather originates in enhanced sympathetic activation...
  71. ncbi request reprint The effect of oral glucose loads on tissue metabolism during angiotensin II receptor and beta-receptor blockade in obese hypertensive subjects
    M Boschmann
    Franz Volhard Clinical Research Center, Charité Campus Buch and HELIOS Klinikum, Berlin, Berlin, Germany
    Horm Metab Res 38:323-9. 2006
    ..The exact mechanism by which inhibition of the renin-angiotensin-aldosterone system decreases the diabetes risk remains unresolved and requires further study...
  72. ncbi request reprint Acute effect of water on blood pressure. What do we know?
    Jens Jordan
    Franz Volhard Clinical Research Center, Medical Faculty of the Charite, Humboldt University, Wiltbergstrasse 50, 13125 Berlin, Germany
    Clin Auton Res 12:250-5. 2002
    ..The cardiovascular effects seem to be in part mediated through sympathetic activation. The exact mechanism that causes the sympathetic activation is not known...
  73. ncbi request reprint Niacin lowers serum phosphate and increases HDL cholesterol in dialysis patients
    Daniela Muller
    Franz Volhard Clinic, Department of Nephrology and Hypertension, Medical Faculty of the Charite, HELIOS Klinikum Berlin, Berlin, Germany
    Clin J Am Soc Nephrol 2:1249-54. 2007
    ..Adverse effects complicate the use of drugs that are prescribed for phosphate control in dialysis patients. Alternative treatment options are needed...
  74. ncbi request reprint Genetic influences on baroreflex function in normal twins
    J Tank
    Clinical Research Center, , , Humboldt University, Berlin, Germany
    Hypertension 37:907-10. 2001
    ..36 to 0.44). The genetic influence on BRS remained strong after correction for BMI and blood pressure. Therefore, BRS is strongly genetically determined, probably by different genes than are resting blood pressure and BMI...
  75. ncbi request reprint Contrasting actions of pressor agents in severe autonomic failure
    J Jordan
    Clinical Research Center, Franz Volhard Clinic, Berlin, Germany
    Am J Med 105:116-24. 1998
    ..Orthostatic hypotension is the most disabling symptom of autonomic failure. The choice of a pressor agent is largely empiric, and it would be of great value to define predictors of a response...
  76. doi request reprint Neurohumoral and metabolic response to exercise in water
    S Wiesner
    Franz Volhard Clinical Research Center, Medical Faculty of the Charité and HELIOS Klinikum, Berlin, Germany
    Horm Metab Res 42:334-9. 2010
    ..Even though water immersion blunts exercise-induced sympathoadrenal activation, lipid mobilization and lipid oxidation rate are maintained or even improved. The response may be explained by augmented ANP release...
  77. ncbi request reprint Interaction of carbon dioxide and sympathetic nervous system activity in the regulation of cerebral perfusion in humans
    J Jordan
    Clinical Research Center, Franz Volhard Clinic, Humboldt University, Berlin, Germany
    Hypertension 36:383-8. 2000
    ..This phenomenon may indicate a moderate direct effect of the sympathetic nervous system on the cerebral vasculature. Furthermore, sympathetic activation tends to increase ventilation and thus can indirectly increase cerebrovascular tone...
  78. ncbi request reprint Severely impaired baroreflex-buffering in patients with monogenic hypertension and neurovascular contact
    J Jordan
    Clinical Research Center, Franz Volhard Clinic, Medical Faculty of the Charite, Humboldt University, Berlin, Germany
    Circulation 102:2611-8. 2000
    ..Neurovascular contact of the ventrolateral medulla may lead to arterial hypertension by interfering with baroreflex function...
  79. ncbi request reprint Osmosensitive mechanisms contribute to the water drinking-induced pressor response in humans
    A Lipp
    Department of Neurology, Medical University Charité, Berlin, Germany
    Neurology 65:905-7. 2005
    ..We reasoned that gastrointestinal distention, hyposomotic stimulation, or both contribute to the water-induced pressor response...
  80. ncbi request reprint Autonomic nervous system function in patients with monogenic hypertension and brachydactyly: a field study in north-eastern Turkey
    J Tank
    Clinical Research Center, Franz Volhard Clinic, , Berlin, Germany
    J Hum Hypertens 15:787-92. 2001
    ....
  81. ncbi request reprint Limited effect of systemic beta-blockade on sympathetic outflow
    J Tank
    Clinical Research Center, HELIOS Kliniken, Franz Volhard Clinic and Max Delbrück Center for Molecular Medicine, Medical Faculty of the Charite, Humboldt University, Berlin, Germany
    Hypertension 38:1377-81. 2001
    ..This, observation is not consistent with an important tonic stimulatory effect of beta-adrenoreceptors in the brain...
  82. doi request reprint Determinants of exercise-induced fat oxidation in obese women and men
    S Haufe
    Franz Volhard Clinical Research Center at the Experimental and Clinical Research Center, Charité University Medical School and Max Delbrück Center for Molecular Medicine, Berlin, Germany
    Horm Metab Res 42:215-21. 2010
    ..We conclude that in obese subjects the capacity to oxidize fat during exercise appears to be limited by skeletal muscle mass and oxidative capacity rather than the availability of visceral or intramyocellular fat...
  83. ncbi request reprint Modulation of QT interval during autonomic nervous system blockade in humans
    Andre Diedrich
    Autonomic Dysfunction Center, Vanderbilt University, Nashville, Tenn 37232 2195, USA
    Circulation 106:2238-43. 2002
    ..We used the alternative approach of interrupting neurotransmission at the level of autonomic ganglia to determine its effect on the QT interval...
  84. ncbi request reprint Heart rate variability and baroreflex function in AT2 receptor-disrupted mice
    Volkmar Gross
    Max Delbruck Center for Molecular Medicine, HELIOS Klinikum Berlin, Germany
    Hypertension 40:207-13. 2002
    ..We conclude that activation of the AT2 receptor impairs arterial baroreceptor reflex function, probably by a central action. These data support the existence of an inhibitory central effect of the AT2 receptor on baroreflex function...
  85. ncbi request reprint Sodium paradoxically reduces the gastropressor response in patients with orthostatic hypotension
    Satish R Raj
    Autonomic Dysfunction Center, Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University, Nashville, TN, USA
    Hypertension 48:329-34. 2006
    ..These data suggest a potentially important role for gastrointestinal osmolality in the activation of the sympathetic nervous system leading to cardiovascular reflexes responsible for the gastropressor response...
  86. ncbi request reprint Water drinking as a treatment for orthostatic syndromes
    John R Shannon
    Nathan Blaser Shy Drager Research Program, Autonomic Dysfunction Center, Vanderbilt University, Nashville, Tennessee, USA
    Am J Med 112:355-60. 2002
    ..We tested the hypothesis that water drinking can be used as a practical treatment for patients with orthostatic and postprandial hypotension, as well as those with orthostatic tachycardia...
  87. ncbi request reprint Selective norepinephrine reuptake inhibition as a human model of orthostatic intolerance
    Christoph Schroeder
    Clinical Research Center, Helios Klinkum Berlin, Germany
    Circulation 105:347-53. 2002
    ..Observations in patients with functional mutations of the norepinephrine transporter (NET) gene suggest that impaired norepinephrine uptake may contribute to idiopathic orthostatic intolerance...
  88. ncbi request reprint Norepinephrine transporter function and autonomic control of metabolism
    Michael Boschmann
    German Institute of Human Nutrition, 14558 Potsdam, Germany
    J Clin Endocrinol Metab 87:5130-7. 2002
    ..This effect cannot be explained by increased systemic or adipose tissue norepinephrine concentrations. Instead, NET inhibition may sensitize adipose tissue to beta-adrenergic stimulation...
  89. ncbi request reprint Tissue-specific response to interstitial angiotensin II in humans
    Michael Boschmann
    German Institute of Human Nutrition, Department of Biochemistry and Physiology of Nutrition, Potsdam, Germany
    Hypertension 41:37-41. 2003
    ..However, interstitial angiotensin II modulates lipid and carbohydrate metabolism in a tissue specific fashion. Thus, the physiology of interstitial angiotensin II cannot be predicted from intravascular studies...
  90. ncbi request reprint Contribution of endothelial nitric oxide to blood pressure in humans
    Alfredo Gamboa
    Department of Medicine, Vanderbilt University, Nashville, TN 37212, USA
    Hypertension 49:170-7. 2007
    ..Our results suggest that eNO is one of the most potent metabolic determinants of BP in humans, tonically restraining it by approximately 30 mm Hg...
  91. ncbi request reprint Women have lower tonic autonomic support of arterial blood pressure and less effective baroreflex buffering than men
    Demetra D Christou
    Department of Integrative Physiology, University of Colorado at Boulder, 354 UCB, Boulder, CO 80309, USA
    Circulation 111:494-8. 2005
    ..Short-term and tonic regulation of arterial blood pressure (BP) differ in premenopausal women and men of similar age. The autonomic nervous system (ANS) plays a critical role in BP regulation...
  92. ncbi request reprint Retinol-binding protein 4 in human obesity
    Jurgen Janke
    Franz Volhard Clinical Research Center Haus 129, Charite Campus Buch, Wiltbergstr 50, 13125 Berlin, Germany
    Diabetes 55:2805-10. 2006
    ..Our findings point to profound differences between rodents and humans in the regulation of adipose or circulating RBP4 and challenge the notion that glucose uptake by adipocytes has a dominant role in the regulation of RBP4...
  93. ncbi request reprint Autonomic cardiovascular and respiratory control during prolonged spaceflights aboard the International Space Station
    Roman M Baevsky
    Institute of Biomedical Problems, Moscow, Russia
    J Appl Physiol 103:156-61. 2007
    ..The decrease in HRV during controlled respiration (6 breaths/min) indicates reduced parasympathetic reserve, which may contribute to postflight disturbances...
  94. ncbi request reprint Water drinking induces thermogenesis through osmosensitive mechanisms
    Michael Boschmann
    Franz Volhard Clinical Research Center and Helios Klinikum Berlin, Charite Campus Buch, Universitary Medicine Berlin, Wiltbergstrasse 50, Hs 129, D 13125 Berlin, Germany
    J Clin Endocrinol Metab 92:3334-7. 2007
    ..Recently, we showed that drinking 500 ml water induces thermogenesis in normal-weight men and women...
  95. pmc NO-dependent blood pressure regulation in RGS2-deficient mice
    Michael Obst
    Max Delbruck Center for Molecular Medicine, Robert Rossle Strasse 10, 13125 Berlin, Germany
    Am J Physiol Regul Integr Comp Physiol 290:R1012-9. 2006
    ..The MAP increases during the active phase in RGS2(-/-) mice may be related to central sympathetic activation and increased vascular adrenergic responsiveness...
  96. ncbi request reprint Central chemoreflex sensitivity and sympathetic neural outflow in elite breath-hold divers
    Zeljko Dujic
    Dept of Physiology, Univ of Split School of Medicine, Soltanska 2, 21000 Split, Croatia
    J Appl Physiol (1985) 104:205-11. 2008
    ..Repeated episodes of hypoxemia may not be sufficient to drive an increase in resting sympathetic activity in the absence of additional comorbidities...
  97. ncbi request reprint Sympathetic genes, baroreflexes, and hypertension
    Jens Jordan
    Clin Auton Res 14:358-9. 2004
  98. ncbi request reprint Autonomic nervous system and blood pressure regulation in RGS2-deficient mice
    Volkmar Gross
    Max Delbruck Center for Molecular Medicine, Robert Rossle Strasse 10, 13125 Berlin, Germany
    Am J Physiol Regul Integr Comp Physiol 288:R1134-42. 2005
    ..A central nervous system mechanism might be implicated by an increased sympathetic tone. This state of affairs could lead to a baroreceptor-HR reflex resetting, while BRS remains unimpaired...
  99. ncbi request reprint Water potentiates the pressor effect of ephedra alkaloids
    Jens Jordan
    Department of Medicine and Pharmacology, Vanderbilt University, Nashville, Tenn 37212, USA
    Circulation 109:1823-5. 2004
    ..We therefore investigated the effects of ephedra alkaloids in patients with autonomic impairment and explored their potential interaction with water ingestion...
  100. ncbi request reprint Bound leptin and sympathetic outflow in nonobese men
    Jens Tank
    HELIOS Kliniken Berlin, Franz Volhard Cardiovascular Research Center, Medical Faculty of the Charite, Humboldt University, 13125 Berlin, Germany
    J Clin Endocrinol Metab 88:4955-9. 2003
    ..This relationship cannot be explained by a direct central nervous effect of protein-bound leptin. Instead, protein-bound leptin may increase sympathetic vasomotor tone indirectly via a baroreflex mechanism...
  101. ncbi request reprint The sympathetic nervous system in hypertension: assessment by blood pressure variability and ganglionic blockade
    Andre Diedrich
    Autonomic Dysfunction Center, Vanderbilt University, Nashville, TN 37232 2195, USA
    J Hypertens 21:1677-86. 2003
    ....