Thomas Häupl

Summary

Affiliation: Humboldt University
Country: Germany

Publications

  1. doi request reprint [Biomarkers in rheumatology. Biomarkers and imaging for the diagnosis and stratification of rheumatoid arthritis and spondylarthritis in the ArthroMark network funded by the Federal Ministry of Education and Research]
    T Haupl
    Medizinische Klinik m S Rheumatologie und Klinische Immunologie, Charite Universitatsmedizin Berlin, Campus Mitte, Chariteplatz 1, 10117, Berlin, Deutschland
    Z Rheumatol 71:314-8. 2012
  2. pmc Crosstalks between integrin alpha 5 and IGF2/IGFBP2 signalling trigger human bone marrow-derived mesenchymal stromal osteogenic differentiation
    Zahia Hamidouche
    Laboratory of Osteoblast Biology and Pathology, INSERM U606, Paris F 75475, France
    BMC Cell Biol 11:44. 2010
  3. pmc Transcriptional profiles discriminate bone marrow-derived and synovium-derived mesenchymal stem cells
    Farida Djouad
    INSERM Unit 475, Montpellier, France
    Arthritis Res Ther 7:R1304-15. 2005
  4. pmc Perspectives and limitations of gene expression profiling in rheumatology: new molecular strategies
    Thomas Häupl
    Department of Rheumatology, Charite, Berlin, Germany
    Arthritis Res Ther 6:140-6. 2004
  5. doi request reprint Reactivation of rheumatoid arthritis after pregnancy: increased phagocyte and recurring lymphocyte gene activity
    Thomas Häupl
    Department of Rheumatology and Clinical Immunology, Charite University Medicine, Berlin, Germany
    Arthritis Rheum 58:2981-92. 2008
  6. ncbi request reprint Gene expression profiling of rheumatoid arthritis synovial cells treated with antirheumatic drugs
    Thomas Häupl
    Tissue Engineering Laboratory, Department of Rheumatology, Charite Universitatsmedizin Berlin, Campus Mitte, Tucholskystrasse 2, 10117 Berlin, Germany
    J Biomol Screen 12:328-40. 2007
  7. doi request reprint Interaction between rheumatoid arthritis and pregnancy: correlation of molecular data with clinical disease activity measures
    T Haupl
    Department of Rheumatology and Clinical Immunology, Charite University Medicine, Tucholskystr 2, 10117 Berlin, Germany
    Rheumatology (Oxford) 47:iii19-22. 2008
  8. ncbi request reprint [New aspects of molecular biology diagnosis. Array technology and expression profile for characterization of rheumatic diseases]
    T Haupl
    Charite, Humboldt Universität Tucholskystr 2 10117 Berlin, Germany
    Z Rheumatol 61:396-404. 2002
  9. ncbi request reprint [Tissue engineering: chances and challenges for application in rheumatic diseases]
    T Haupl
    Humboldt Universitat, Tucholskystr 2, 10117 Berlin, Germany
    Z Rheumatol 62:II46-9. 2003
  10. ncbi request reprint BMP2 initiates chondrogenic lineage development of adult human mesenchymal stem cells in high-density culture
    Bernhard Schmitt
    Tissue Engineering Laboratory, Department of Rheumatology, Medical Faculty Charité, Humboldt University of Berlin, Tucholskystrasse 2, 10117 Berlin, Germany
    Differentiation 71:567-77. 2003

Collaborators

Detail Information

Publications42

  1. doi request reprint [Biomarkers in rheumatology. Biomarkers and imaging for the diagnosis and stratification of rheumatoid arthritis and spondylarthritis in the ArthroMark network funded by the Federal Ministry of Education and Research]
    T Haupl
    Medizinische Klinik m S Rheumatologie und Klinische Immunologie, Charite Universitatsmedizin Berlin, Campus Mitte, Chariteplatz 1, 10117, Berlin, Deutschland
    Z Rheumatol 71:314-8. 2012
    ..To validate the markers for diagnostic application the network aims to expand gradually...
  2. pmc Crosstalks between integrin alpha 5 and IGF2/IGFBP2 signalling trigger human bone marrow-derived mesenchymal stromal osteogenic differentiation
    Zahia Hamidouche
    Laboratory of Osteoblast Biology and Pathology, INSERM U606, Paris F 75475, France
    BMC Cell Biol 11:44. 2010
    ..In this study, we used microarray analysis to identify signalling molecules that promote osteogenic differentiation in human bone marrow stroma derived MSCs...
  3. pmc Transcriptional profiles discriminate bone marrow-derived and synovium-derived mesenchymal stem cells
    Farida Djouad
    INSERM Unit 475, Montpellier, France
    Arthritis Res Ther 7:R1304-15. 2005
    ....
  4. pmc Perspectives and limitations of gene expression profiling in rheumatology: new molecular strategies
    Thomas Häupl
    Department of Rheumatology, Charite, Berlin, Germany
    Arthritis Res Ther 6:140-6. 2004
    ..Genomic and proteomic technologies will therefore be complementary in their scientific and clinical application...
  5. doi request reprint Reactivation of rheumatoid arthritis after pregnancy: increased phagocyte and recurring lymphocyte gene activity
    Thomas Häupl
    Department of Rheumatology and Clinical Immunology, Charite University Medicine, Berlin, Germany
    Arthritis Rheum 58:2981-92. 2008
    ..This study was undertaken to generate a systematic overview of the molecular mechanisms related to disease remission and postpartum reactivation...
  6. ncbi request reprint Gene expression profiling of rheumatoid arthritis synovial cells treated with antirheumatic drugs
    Thomas Häupl
    Tissue Engineering Laboratory, Department of Rheumatology, Charite Universitatsmedizin Berlin, Campus Mitte, Tucholskystrasse 2, 10117 Berlin, Germany
    J Biomol Screen 12:328-40. 2007
    ..Synovial fibroblasts reflect the disease-related pathophysiology and are useful tools for screening putative antirheumatic compounds...
  7. doi request reprint Interaction between rheumatoid arthritis and pregnancy: correlation of molecular data with clinical disease activity measures
    T Haupl
    Department of Rheumatology and Clinical Immunology, Charite University Medicine, Tucholskystr 2, 10117 Berlin, Germany
    Rheumatology (Oxford) 47:iii19-22. 2008
    ..This prompted us to investigate correlations between clinical parameters of disease activity and gene profiles...
  8. ncbi request reprint [New aspects of molecular biology diagnosis. Array technology and expression profile for characterization of rheumatic diseases]
    T Haupl
    Charite, Humboldt Universität Tucholskystr 2 10117 Berlin, Germany
    Z Rheumatol 61:396-404. 2002
    ....
  9. ncbi request reprint [Tissue engineering: chances and challenges for application in rheumatic diseases]
    T Haupl
    Humboldt Universitat, Tucholskystr 2, 10117 Berlin, Germany
    Z Rheumatol 62:II46-9. 2003
    ..These together with the advances in biological therapies of rheumatic diseases are the basis of new concepts, which promise application of tissue engineering also in inflammatory joint diseases...
  10. ncbi request reprint BMP2 initiates chondrogenic lineage development of adult human mesenchymal stem cells in high-density culture
    Bernhard Schmitt
    Tissue Engineering Laboratory, Department of Rheumatology, Medical Faculty Charité, Humboldt University of Berlin, Tucholskystrasse 2, 10117 Berlin, Germany
    Differentiation 71:567-77. 2003
    ..These results suggest BMP2 as a promising candidate for tissue engineering approaches regenerating articular cartilage on the basis of mesenchymal progenitors from bone marrow...
  11. pmc Antirheumatic drug response signatures in human chondrocytes: potential molecular targets to stimulate cartilage regeneration
    Kristin Andreas
    Tissue Engineering Laboratory and Berlin Brandenburg Center for Regenerative Therapies, Department of Rheumatology, Charite Universitatsmedizin Berlin, Tucholskystrasse 2, 10117 Berlin, Germany
    Arthritis Res Ther 11:R15. 2009
    ..This study aimed to disclose major mechanisms of antirheumatic drug action on human chondrocytes and to reveal marker and pharmacological target genes that are involved in cartilage dysfunction and regeneration...
  12. doi request reprint Defining TNF-α- and LPS-induced gene signatures in monocytes to unravel the complexity of peripheral blood transcriptomes in health and disease
    Biljana Smiljanovic
    Deutsches Rheuma Forschungszentrum Berlin DRFZ, a Leibniz Institute, Chariteplatz 1, 10117, Berlin, Germany
    J Mol Med (Berl) 88:1065-79. 2010
    ....
  13. pmc Chondrogenic differentiation of human subchondral progenitor cells is affected by synovial fluid from donors with osteoarthritis or rheumatoid arthritis
    Jan Philipp Krüger
    TransTissue Technologies GmbH, Chariteplatz 1, 10117 Berlin, Germany
    J Orthop Surg Res 7:10. 2012
    ..The aim of our study was to investigate the effects of joint disease conditions on the in vitro chondrogenesis of human CSP...
  14. pmc Key regulatory molecules of cartilage destruction in rheumatoid arthritis: an in vitro study
    Kristin Andreas
    Tissue Engineering Laboratory and Berlin Brandenburg Center for Regenerative Therapies, Department of Rheumatology, Charite Universitatsmedizin Berlin, Tucholskystrasse 2, 10117 Berlin, Germany
    Arthritis Res Ther 10:R9. 2008
    ..Hence, the objective of this study was to establish a standardized in vitro model to profile the key regulatory molecules of RA-related destruction of cartilage that are expressed by human chondrocytes...
  15. doi request reprint The multifaceted balance of TNF-α and type I/II interferon responses in SLE and RA: how monocytes manage the impact of cytokines
    Biljana Smiljanovic
    Deutsches Rheuma Forschungszentrum Berlin DRFZ, ein Leibniz Institut, Chariteplatz 1, 10117 Berlin, Germany
    J Mol Med (Berl) 90:1295-309. 2012
    ..The results suggest that an assessment of cytokine-response status in monocytes may be helpful for improvement of diagnosis and selection of the best cytokine target for therapeutic intervention...
  16. pmc Differential gene expression profiling of human bone marrow-derived mesenchymal stem cells during adipogenic development
    Adriane Menssen
    Tissue Engineering Laboratory, Clinic for Rheumatology and Clinical Immunology, Charite Universitatsmedizin Berlin, Charite Platz 1, 10117 Berlin, Germany
    BMC Genomics 12:461. 2011
    ..For data processing and selection of adipogenic candidate genes, we used the online database SiPaGene for Affymetrix microarray expression data...
  17. doi request reprint Chondrogenic differentiation of human subchondral progenitor cells is impaired by rheumatoid arthritis synovial fluid
    Jan Philipp Krüger
    TransTissue Technologies GmbH, Berlin, Germany
    J Orthop Res 28:819-27. 2010
    ..These results suggest that SF from RA patients may impair the chondrogenic development of mesenchymal progenitors in microfracture, whereas osteoarthritic SF may has no negative effect on the cartilage matrix formation...
  18. pmc Reverse differentiation as a gene filtering tool in genome expression profiling of adipogenesis for fat marker gene selection and their analysis
    Mujib Ullah
    Tissue Engineering Laboratory and Berlin Brandenburg Center for Regenerative Therapies, Department of Rheumatology and Clinical Immunology, Charite University Medicine Berlin, Berlin, Germany
    PLoS ONE 8:e69754. 2013
    ..We hypothesize that exclusively adipogenic-specific genes change their expression during adipogenesis, and reverse during dedifferentiation. Thus, MSC were adipogenic differentiated and dedifferentiated...
  19. doi request reprint Tissue-engineered cartilage of porcine and human origin as in vitro test system in arthritis research
    Axel R Göhring
    Tissue Engineering Laboratory and Berlin Brandenburg Center for Regenerative Therapies, Dept of Rheumatology and Clinical Immunology, Charite Universitatsmedizin Berlin, Tucholskystrasse 2, Berlin, Germany
    Biotechnol Prog 26:1116-25. 2010
    ..Therefore, we demonstrate that engineered cartilage of porcine and human origin represents a powerful in vitro model for cartilage in vivo...
  20. ncbi request reprint Synovial fluid recruits human mesenchymal progenitors from subchondral spongious bone marrow
    Michaela Endres
    TransTissue Technologies GmbH, Tucholskystrasse 2, 10117 Berlin, Germany
    J Orthop Res 25:1299-307. 2007
    ..0001). The chemotactic activity of SF obtained from normal donors and from patients with degenerative joint diseases suggests that SF may be actively involved in the migration of progenitors in cartilage defects after microfracture...
  21. ncbi request reprint BMP7 promotes adipogenic but not osteo-/chondrogenic differentiation of adult human bone marrow-derived stem cells in high-density micro-mass culture
    Katja Neumann
    TransTissue Technologies GmbH, Tucholskystrasse 2, 10117 Berlin, Germany
    J Cell Biochem 102:626-37. 2007
    ..These results suggest that BMP7 promotes the adipogenic and not the osteogenic or chondrogenic lineage development of human stem cells when assembled three-dimensionally in micro-masses...
  22. doi request reprint Adaptation of human CD4+ T cells to pathophysiological hypoxia: a transcriptome analysis
    Timo Gaber
    Department of Rheumatology and Clinical Immunology, Charite University Hospital, Chariteplatz 1, 10117 Berlin, Germany
    J Rheumatol 36:2655-69. 2009
    ..Inflamed tissues are usually characterized by low oxygen levels. We investigated whether pathophysiological hypoxia (pO(2) < 1%) as found in the rheumatoid synovium modulates the transcriptome of human CD4+ T cells...
  23. pmc SiPaGene: A new repository for instant online retrieval, sharing and meta-analyses of GeneChip expression data
    Adriane Menssen
    Department of Rheumatology and Clinical Immunology, Charite University Hospital, Chariteplatz 1, Berlin, Germany
    BMC Genomics 10:98. 2009
    ..Furthermore, most of the currently existing tools do not use the whole range of statistical power provided by the MAS5.0/GCOS algorithms...
  24. doi request reprint Gene expression profile of adult human bone marrow-derived mesenchymal stem cells stimulated by the chemokine CXCL7
    Gregor Kalwitz
    TransTissue Technologies GmbH, Tucholskystrasse 2, 10117 Berlin, Germany
    Int J Biochem Cell Biol 41:649-58. 2009
    ..Pathway analysis suggests that recruitment of human MSC by CXCL7 is supported by the induction of ligands of the interleukin 8 receptors, synergistically activating the respective signaling pathways...
  25. doi request reprint Gene expression profiling of human mesenchymal stem cells chemotactically induced with CXCL12
    Stefan Stich
    Tissue Engineering Laboratory and Berlin Brandenburg Center for Regenerative Therapies, Department of Rheumatology and Clinical Immunology, Charite University Medicine Berlin, Berlin, Germany
    Cell Tissue Res 336:225-36. 2009
    ..The obtained data provide further insights into the molecular mechanisms involved in chemotactic processes in cell migration and designate CXCL12 as a promising candidate for in situ recruitment in regenerative therapies...
  26. doi request reprint A1.18 From tissue- and cell-specific transcriptomes to candidate markers in rheumatoid arthritis
    Biljana Smiljanovic
    Department of Rheumatology and Clinical Immunology, Charité CCM, Chariteplatz 1, 10117 Berlin, Germany
    Ann Rheum Dis 73:A7-8. 2014
    ..Based on transcriptome data candidate markers were selected and validated at the protein level...
  27. doi request reprint A8.16 T helper lymphocytes and monocytes as biosensors of type I interferon responses in viral infection and autoimmunity
    Chieko Kyogoku
    German Rheumatism Research Centre DRFZ Berlin, An Institute of the Leibniz Association, Berlin, Germany
    Ann Rheum Dis 73:A82. 2014
    ..In this study we show that these cell-specific IFN signatures are not only working in isolated cell subsets but are even robust enough to classify PBMC in viral infection and autoimmunity...
  28. ncbi request reprint Gene expression profiling of human articular cartilage grafts generated by tissue engineering
    Christian Kaps
    Tissue Engineering Laboratory, Department of Rheumatology, Charite Universitatsmedizin Berlin, Campus Mitte, Tucholskystr 2, 10117 Berlin, Germany
    Biomaterials 27:3617-30. 2006
    ..Three-dimensional tissue culture of expanded articular chondrocytes initiates chondrocyte re-differentiation in vitro and leads to the maturation of cartilage grafts towards hyaline cartilage in vivo...
  29. ncbi request reprint Strategies using functional genomics in rheumatic diseases
    Gerd R Burmester
    Department of Rheumatology and Clinical Immunology, Charite University Medicine Berlin, Humboldt University and Free University of Berlin, Schumannstr 20 21, 10098 Berlin, Germany
    Autoimmun Rev 3:541-9. 2004
    ....
  30. doi request reprint Human CD4(+) T cells maintain specific functions even under conditions of extremely restricted ATP production
    Robert Tripmacher
    Department of Rheumatology and Clinical Immunology, Charite University Medicine, Berlin, Germany
    Eur J Immunol 38:1631-42. 2008
    ..Our data demonstrate an unexpectedly high, clinically relevant adaptive potential of human CD4(+) T cells to maintain specific functions even under severely impaired bioenergetic conditions...
  31. doi request reprint Fibrinogen and factor XIII A-subunit genotypes interactively influence C-reactive protein levels during inflammation
    Berthold Hoppe
    Institute of Laboratory Medicine, Clinical Chemistry and Pathobiochemistry, Charite Universitatsmedizin Berlin, Campus Virchow Klinikum, Augustenburger Platz 1, 13353 Berlin, Germany
    Ann Rheum Dis 71:1163-9. 2012
    ....
  32. doi request reprint Sialic acid-binding Ig-like lectin 1 expression in inflammatory and resident monocytes is a potential biomarker for monitoring disease activity and success of therapy in systemic lupus erythematosus
    Robert Biesen
    Charite Universitatsmedizin Berlin, Humboldt University of Berlin, Germany
    Arthritis Rheum 58:1136-45. 2008
    ..This study was undertaken to establish a feasible biomarker for IFN effects with respect to disease activity and effectiveness of IFN-suppressive therapy in SLE patients...
  33. ncbi request reprint Porcine mesenchymal stem cells. Induction of distinct mesenchymal cell lineages
    Jochen Ringe
    Department of Rheumatology, University Medical Center, Charite, The Humboldt University of Berlin, Germany
    Cell Tissue Res 307:321-7. 2002
    ..Therefore, porcine MSC may be introduced as a valuable model system with which to study the mesenchymal lineages for basic research and tissue engineering...
  34. doi request reprint The physiologic increase in expression of some type I IFN-inducible genes during pregnancy is not associated with improved disease activity in pregnant patients with rheumatoid arthritis
    Janine Weix
    Department of Rheumatology, Charite Universitatsmedizin Berlin, Berlin, Germany
    Transl Res 161:505-12. 2013
    ..However, an association of type I IFN-inducible genes with pregnancy induced disease amelioration seems unlikely...
  35. doi request reprint Transcriptional profiling of the hematopoietic support of interleukin-stimulated human umbilical vein endothelial cells (HUVECs)
    Gürkan Bal
    Institute for Transfusion Medicine, Charite Universitatsmedizin Berlin, Berlin, Germany
    Cell Transplant 21:251-67. 2012
    ..Our results suggest that microarray in combination with functional annotations is a convenient method to identify novel factors with great impact on HPC proliferation and differentiation...
  36. ncbi request reprint Future of tissue engineering in rheumatic diseases
    Jochen Ringe
    Charite University Medicine Berlin, Tissue Engineering Laboratory and Berlin Brandenburg Center for Regenerative Therapies, Department of Rheumatology and Clinical Immunology, Tucholskystr 2, 10117 Berlin, Germany
    Expert Opin Biol Ther 7:283-7. 2007
    ..This review focuses on state-of-the-art and future in situ mesenchymal stem cell-based tissue engineering approaches for joint repair in patients with rheumatic diseases...
  37. doi request reprint V-region gene analysis of locally defined synovial B and plasma cells reveals selected B cell expansion and accumulation of plasma cell clones in rheumatoid arthritis
    Tobias Scheel
    Deutsches Rheuma ForschungsZentrum, Berlin, Germany
    Arthritis Rheum 63:63-72. 2011
    ....
  38. ncbi request reprint Array technology and proteomics in autoimmune diseases
    Veit Krenn
    Department of Pathology, Universitatsklinikum Charite, Schumannstrasse 20121, Berlin 10117, Germany
    Pathol Res Pract 200:95-103. 2004
    ..Novel targets of drug discovery, based on antigen-specific therapies to induce anergy, or regulatory T-cells using the targeted autoantigens of individual patients could be developed in the coming decades...
  39. ncbi request reprint [Mesenchymal stem cells for tissue engineering of bone and cartilage]
    Jochen Ringe
    Labor für Tissue Engineering, Medizinische Klinik mit Schwerpunkt für Rheumatologie und Klinische Immunologie, Universitatsklinikum Charite, Humboldt Uni versität Berlin
    Med Klin (Munich) 98:35-40. 2003
    ..In this article, important aspects of tissue engineering of bone and cartilage will be reviewed with emphasis on mesenchymal stem cells...
  40. pmc Detailed analysis of the variability of peptidylarginine deiminase type 4 in German patients with rheumatoid arthritis: a case-control study
    Berthold Hoppe
    Institute of Transfusion Medicine, Campus Virchow Klinikum, Charite Universitatsmedizin Berlin, Germany
    Arthritis Res Ther 8:R34. 2006
    ..Quantitative or qualitative differences in previously undefined PADI4 variants between patients and controls could not be demonstrated...
  41. doi request reprint Influence of pregnancy on the adipocytokine and peroxisome proliferator-activated receptor pathways in peripheral blood mononuclear cells from healthy donors and rheumatoid arthritis patients
    Janine Weix
    University Hospital and University of Bern, Bern, Switzerland
    Arthritis Rheum 64:2095-103. 2012
    ..To identify candidate genes that are regulated by human pregnancy and have the potential to modulate rheumatoid arthritis (RA) disease activity...
  42. pmc Autoregulation of Th1-mediated inflammation by twist1
    Uwe Niesner
    German Rheumatism Research Center Berlin, 10117 Berlin, Germany
    J Exp Med 205:1889-901. 2008
    ....