Matthias Huber

Summary

Affiliation: Humboldt University
Country: Germany

Publications

  1. ncbi request reprint Genetic variants implicated in telomere length associated with left ventricular function in patients with hypertension and cardiac organ damage
    Matthias Huber
    Institute of Clinical Pharmacology and Toxicology, CharitéCentrum für Therapieforschung, Charite Universitatsmedizin Berlin, Chariteplatz 1, 10117 Berlin, Germany
    J Mol Med (Berl) 90:1059-67. 2012
  2. doi request reprint Genetics of melatonin receptor type 2 is associated with left ventricular function in hypertensive patients treated according to guidelines
    Matthias Huber
    Institute of Clinical Pharmacology and Toxicology, Charite Universitatsmedizin Berlin, Berlin, Germany Electronic address
    Eur J Intern Med 24:650-5. 2013
  3. doi request reprint Ophthalmic drugs as part of polypharmacy in nursing home residents with glaucoma
    Matthias Huber
    Institute of Clinical Pharmacology and Toxicology, Charite, Universitatsmedizin Berlin, Berlin, Germany
    Drugs Aging 30:31-8. 2013
  4. ncbi request reprint [The eye as target of adverse ocular drug reactions. Focus on systemic antiinfective therapy]
    Matthias Huber
    Charité Universitäts medizin Berlin, Institut fur Klinische Pharmakologie und Toxikologie, Chariteplatz 1, 10117 Berlin
    Med Monatsschr Pharm 35:436-42; quiz 443-4. 2012
  5. doi request reprint Antipsychotic drugs predominate in pharmacotherapy of nursing home residents with dementia
    M Huber
    Institute of Clinical Pharmacology and Toxicology, Charite Universitatsmedizin Berlin, Berlin, Germany
    Pharmacopsychiatry 45:182-8. 2012
  6. doi request reprint [Adverse ocular drug reactions of systemic antimicrobial agents]
    M Huber
    Institut fur Klinische Pharmakologie und Toxikologie, Charite Universitatsmedizin Berlin
    Dtsch Med Wochenschr 137:85-9. 2012
  7. pmc Large-scale mapping of mutations affecting zebrafish development
    Robert Geisler
    Department 3 Genetics, Max Planck Institut fur Entwicklungsbiologie, Spemannstr, 35 III, 72076 Tubingen, Germany
    BMC Genomics 8:11. 2007
  8. doi request reprint Microangiopathy and visual deficits characterize the retinopathy of a spontaneously hypertensive rat model with type 2 diabetes and metabolic syndrome
    Matthias Huber
    Institut fur Klinische Pharmakologie und Toxikologie, Charité Centrum für Therapieforschung, Charite Universitatsmedizin Berlin, Berlin, Germany
    Hypertens Res 34:103-12. 2011
  9. doi request reprint Pharmacokinetics and safety of olmesartan medoxomil in combination with either amlodipine or atenolol compared to respective monotherapies in healthy subjects
    Juliane Bolbrinker
    Institute of Clinical Pharmacology and Toxicology, CharitéCentrum für Therapieforschung, Charite Universitatsmedizin Berlin, Berlin, Germany
    Fundam Clin Pharmacol 23:767-74. 2009
  10. doi request reprint Genetic locus on MWF rat chromosome 6 affects kidney damage in response to L-NAME treatment in spontaneously hypertensive rats
    Angela Schulz
    Department of Clinical Pharmacology and Toxicology, Charité Centrum für Therapieforschung, Charite Universitatsmedizin Berlin, Berlin, Germany
    Physiol Genomics 42:126-33. 2010

Collaborators

Detail Information

Publications17

  1. ncbi request reprint Genetic variants implicated in telomere length associated with left ventricular function in patients with hypertension and cardiac organ damage
    Matthias Huber
    Institute of Clinical Pharmacology and Toxicology, CharitéCentrum für Therapieforschung, Charite Universitatsmedizin Berlin, Chariteplatz 1, 10117 Berlin, Germany
    J Mol Med (Berl) 90:1059-67. 2012
    ..0% to −0.7%; p raw = 0.002, p mt = 0.008) lower EF compared with those lacking this haplotype. Our results point to a role of genetic variants recently implicated in LTL for left ventricular function in hypertensive patients...
  2. doi request reprint Genetics of melatonin receptor type 2 is associated with left ventricular function in hypertensive patients treated according to guidelines
    Matthias Huber
    Institute of Clinical Pharmacology and Toxicology, Charite Universitatsmedizin Berlin, Berlin, Germany Electronic address
    Eur J Intern Med 24:650-5. 2013
    ..We thus investigated single nucleotide polymorphisms (SNPs) of MTNR1B in relation to blood pressure (BP) and cardiac parameters in hypertensive patients...
  3. doi request reprint Ophthalmic drugs as part of polypharmacy in nursing home residents with glaucoma
    Matthias Huber
    Institute of Clinical Pharmacology and Toxicology, Charite, Universitatsmedizin Berlin, Berlin, Germany
    Drugs Aging 30:31-8. 2013
    ..But this therapeutic approach may include risks for adverse drug effects and drug-drug interactions, of particular importance in frail nursing home resident populations...
  4. ncbi request reprint [The eye as target of adverse ocular drug reactions. Focus on systemic antiinfective therapy]
    Matthias Huber
    Charité Universitäts medizin Berlin, Institut fur Klinische Pharmakologie und Toxikologie, Chariteplatz 1, 10117 Berlin
    Med Monatsschr Pharm 35:436-42; quiz 443-4. 2012
    ..In summary, this review indicates the complexity of ocular adverse drug reactions and points out that an interdisciplinary approach is necessary to improve pharmacovigilance in this field...
  5. doi request reprint Antipsychotic drugs predominate in pharmacotherapy of nursing home residents with dementia
    M Huber
    Institute of Clinical Pharmacology and Toxicology, Charite Universitatsmedizin Berlin, Berlin, Germany
    Pharmacopsychiatry 45:182-8. 2012
    ..Data of a German health insurance company were retrospectively analyzed for the year 2008...
  6. doi request reprint [Adverse ocular drug reactions of systemic antimicrobial agents]
    M Huber
    Institut fur Klinische Pharmakologie und Toxikologie, Charite Universitatsmedizin Berlin
    Dtsch Med Wochenschr 137:85-9. 2012
    ....
  7. pmc Large-scale mapping of mutations affecting zebrafish development
    Robert Geisler
    Department 3 Genetics, Max Planck Institut fur Entwicklungsbiologie, Spemannstr, 35 III, 72076 Tubingen, Germany
    BMC Genomics 8:11. 2007
    ..Here we report on a large-scale effort to map the mutations generated in mutagenesis screening at the Max Planck Institute for Developmental Biology by genome scanning with microsatellite markers...
  8. doi request reprint Microangiopathy and visual deficits characterize the retinopathy of a spontaneously hypertensive rat model with type 2 diabetes and metabolic syndrome
    Matthias Huber
    Institut fur Klinische Pharmakologie und Toxikologie, Charité Centrum für Therapieforschung, Charite Universitatsmedizin Berlin, Berlin, Germany
    Hypertens Res 34:103-12. 2011
    ..Thus, this model represents a valuable experimental tool to obtain further insights into the mechanisms of retinopathy in the context of obesity, type 2 diabetes and metabolic syndrome...
  9. doi request reprint Pharmacokinetics and safety of olmesartan medoxomil in combination with either amlodipine or atenolol compared to respective monotherapies in healthy subjects
    Juliane Bolbrinker
    Institute of Clinical Pharmacology and Toxicology, CharitéCentrum für Therapieforschung, Charite Universitatsmedizin Berlin, Berlin, Germany
    Fundam Clin Pharmacol 23:767-74. 2009
    ..5 h for each group in each study. Bioequivalence was established for all pharmacokinetic parameters. Lack of significant pharmacokinetic interactions between olmesartan and amlodipine or atenolol provides a basis for combination therapy...
  10. doi request reprint Genetic locus on MWF rat chromosome 6 affects kidney damage in response to L-NAME treatment in spontaneously hypertensive rats
    Angela Schulz
    Department of Clinical Pharmacology and Toxicology, Charité Centrum für Therapieforschung, Charite Universitatsmedizin Berlin, Berlin, Germany
    Physiol Genomics 42:126-33. 2010
    ..Moreover, our data indicate that genes on RNO6 contribute to the development of L-NAME-induced renal damage in the SHR strain...
  11. doi request reprint Role of the angiotensin II type 2 receptor gene (+1675G/A) polymorphism on left ventricular hypertrophy and geometry in treated hypertensive patients
    Matthias Huber
    Institute of Clinical Pharmacology and Toxicology, Charité Centrum für Therapieforschung, Charite Universitatsmedizin Berlin, Berlin, Germany
    J Hypertens 28:1221-9. 2010
    ..We tested whether this polymorphism affects LVH and left ventricular geometry parameters in patients with essential hypertension and cardiovascular disease who are treated according to guidelines...
  12. ncbi request reprint Pharmacokinetics of olmesartan medoxomil plus hydrochlorothiazide combination in healthy subjects
    Reinhold Kreutz
    Department of Clinical Pharmacology and Toxicology, Campus Benjamin Franklin, Charite Universitatsmedizin Berlin, Berlin, Germany
    Clin Drug Investig 26:29-34. 2006
    ..This trial investigated the possibility of pharmacokinetic interactions between the AT1 receptor antagonist olmesartan medoxomil and the thiazide diuretic hydrochlorothiazide in healthy subjects...
  13. doi request reprint Nephron deficit is not required for progressive proteinuria development in the Munich Wistar Frömter rat
    Angela Schulz
    Department of Clinical Pharmacology and Toxicology, CharitéCentrum für Therapieforschung, Charite Universitatsmedizin Berlin, Berlin, Germany
    Physiol Genomics 35:30-5. 2008
    ..The locus on chromosome 8 appears of interest, because its exchange between MWF and SHR protects against the development of albuminuria in MWF-8(SHR) animals despite their inherited nephron deficit and higher systolic blood pressure...
  14. doi request reprint Role of CYP2C9 genetic variants for salt sensitivity and the regulation of the renin-angiotensin-aldosterone system in normotensive men
    Juliane Bolbrinker
    Institute of Clinical Pharmacology and Toxicology, Campus Charite Mitte, Charite Universitatsmedizin Berlin, Berlin, Germany
    J Hypertens 29:56-61. 2011
    ..We tested the relevance of CYP2C9 genotypes for regulation of plasma renin activity (PRA), plasma aldosterone concentrations and blood pressure (BP) in response to changes in salt intake in normotensive individuals...
  15. ncbi request reprint [Potentially inappropriate medication for the elderly: adaptation and evaluation of a French consensus list]
    Marita Kölzsch
    Institut fur Klinische Pharmakologie und Toxikologie, Charite Universitatsmedizin Berlin
    Med Monatsschr Pharm 33:295-302. 2010
    ..Appropriate pharmacotherapy is one of the most important topics due to demographic development in many industrialised countries. The purpose of our work was to evaluate and adjust a French consensus list for Germany...
  16. doi request reprint A twofold genetic increase of ACE expression has no effect on the development of spontaneous hypertension
    Ibrahim Nassar
    Institute of Clinical Pharmacology and Toxicology, Charité Centrum für Thearapieforschung, Charite Universitatsmedizin Berlin, Berlin, Germany
    Am J Hypertens 21:200-5. 2008
    ..e., the Ace allele of the normotensive Wistar-Kyoto (WKY) rat, in the hypertensive background of stroke-prone spontaneously hypertensive (SHRSP) rats...
  17. ncbi request reprint Pharmacokinetics and safety of olmesartan medoxomil in combination with glibenclamide in healthy volunteers
    Matthias Huber
    Department of Clinical Pharmacology and Toxicology, Campus Benjamin Franklin, Charite Universitatsmedizin Berlin, Berlin, Germany
    Clin Exp Hypertens 28:631-43. 2006
    ..To investigate the pharmacokinetic interactions, safety, and tolerability of the combination of olmesartan medoxomil with glibenclamide...