W K Hofmann

Summary

Affiliation: Humboldt University
Country: Germany

Publications

  1. pmc High correlation of the proteome patterns in bone marrow and peripheral blood blast cells in patients with acute myeloid leukemia
    Gero Hütter
    Department of Internal Medicine III Hematology, Onkology, Charité Berlin Campus Benjamin Franklin, Berlin, Germany
    J Transl Med 7:7. 2009
  2. ncbi request reprint Myelodysplastic syndrome
    Wolf K Hofmann
    Department of Hematology and Oncology and Transfusion Medicine, University Hospital Benjamin Franklin, 12200 Berlin, Germany
    Annu Rev Med 56:1-16. 2005
  3. ncbi request reprint Therapeutic spectrum in the treatment of myelodysplastic syndromes
    Wolf K Hofmann
    Charité University Hospital Benjamin Franklin, Department of Hematology and Oncology and Transfusion Medicine, Hindenburgdamm 30, 12203 Berlin, Germany
    Expert Opin Pharmacother 5:2451-8. 2004
  4. ncbi request reprint Comparative analysis of hypermethylation of cell cycle control and DNA-mismatch repair genes in low-density and CD34+ bone marrow cells from patients with myelodysplastic syndrome
    W K Hofmann
    Department of Hematology, University Hospital Benjamin Franklin, Berlin, Germany
    Leuk Res 30:1347-53. 2006
  5. ncbi request reprint Combined automated cell and flow cytometric analysis enables recognition of persistent polyclonal B-cell lymphocytosis (PPBL), a study of 25 patients
    M Schmidt-Hieber
    Medizinische Klinik III, Charite Universitatsmedizin Berlin, Hindenburgdamm 30, 12200, Berlin, Germany
    Ann Hematol 87:829-36. 2008
  6. ncbi request reprint Myelodysplastic syndromes: molecular pathogenesis and genomic changes
    Florian Nolte
    Department of Hematology and Oncology, University Hospital Benjamin Franklin, Charite, Hindenburgdamm 30, 12203, Berlin, Germany
    Ann Hematol 87:777-95. 2008
  7. doi request reprint BAALC-associated gene expression profiles define IGFBP7 as a novel molecular marker in acute leukemia
    S Heesch
    Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Medizinische Klinik III, Berlin, Germany
    Leukemia 24:1429-36. 2010
  8. doi request reprint Survival, prognostic factors and rates of leukemic transformation in 381 untreated patients with MDS and del(5q): a multicenter study
    U Germing
    Department of Hematology, Oncology and Clinical Immunology, Heinrich Heine University Dusseldorf, Dusseldorf, Germany
    Leukemia 26:1286-92. 2012
  9. doi request reprint Genome-wide screen reveals WNT11, a non-canonical WNT gene, as a direct target of ETS transcription factor ERG
    L H Mochmann
    Department of Hematology and Oncology, Charite, Campus Benjamin Franklin, Berlin, Germany
    Oncogene 30:2044-56. 2011
  10. ncbi request reprint Transcriptional profiling of human hematopoiesis during in vitro lineage-specific differentiation
    Martina Komor
    Department of Hematology, Oncology and Transfusion Medicine, University Hospital Benjamin Franklin, Hindenburgdamm 30, 12203 Berlin, Germany
    Stem Cells 23:1154-69. 2005

Collaborators

Detail Information

Publications24

  1. pmc High correlation of the proteome patterns in bone marrow and peripheral blood blast cells in patients with acute myeloid leukemia
    Gero Hütter
    Department of Internal Medicine III Hematology, Onkology, Charité Berlin Campus Benjamin Franklin, Berlin, Germany
    J Transl Med 7:7. 2009
    ..However, it remains to be determined, whether this correlation also exists on the level of protein expression...
  2. ncbi request reprint Myelodysplastic syndrome
    Wolf K Hofmann
    Department of Hematology and Oncology and Transfusion Medicine, University Hospital Benjamin Franklin, 12200 Berlin, Germany
    Annu Rev Med 56:1-16. 2005
    ..Innovative uses of immunomodulatory agents and the optimizing of cytotoxic treatment should continue to help in the treatment of MDS...
  3. ncbi request reprint Therapeutic spectrum in the treatment of myelodysplastic syndromes
    Wolf K Hofmann
    Charité University Hospital Benjamin Franklin, Department of Hematology and Oncology and Transfusion Medicine, Hindenburgdamm 30, 12203 Berlin, Germany
    Expert Opin Pharmacother 5:2451-8. 2004
    ..Furthermore, the innovative use of immunomodulatory agents and the optimising of cytotoxic treatment should continue to help in the treatment of MDS...
  4. ncbi request reprint Comparative analysis of hypermethylation of cell cycle control and DNA-mismatch repair genes in low-density and CD34+ bone marrow cells from patients with myelodysplastic syndrome
    W K Hofmann
    Department of Hematology, University Hospital Benjamin Franklin, Berlin, Germany
    Leuk Res 30:1347-53. 2006
    ..These results indicate that hypermethylation of cell cycle control genes in MDS may occur late during the differentiation of myelodysplastic stem cells...
  5. ncbi request reprint Combined automated cell and flow cytometric analysis enables recognition of persistent polyclonal B-cell lymphocytosis (PPBL), a study of 25 patients
    M Schmidt-Hieber
    Medizinische Klinik III, Charite Universitatsmedizin Berlin, Hindenburgdamm 30, 12200, Berlin, Germany
    Ann Hematol 87:829-36. 2008
    ..The observation of malignant lymphoma in a single patient implicates that evolution into a clonal malignant transformation may occasionally occur in PPBL...
  6. ncbi request reprint Myelodysplastic syndromes: molecular pathogenesis and genomic changes
    Florian Nolte
    Department of Hematology and Oncology, University Hospital Benjamin Franklin, Charite, Hindenburgdamm 30, 12203, Berlin, Germany
    Ann Hematol 87:777-95. 2008
    ..Secondary signal proteins and transcription factors, which gives the cell a growth advantage over its normal counterpart, may be affected as well. The accumulation of such defects may finally cause the leukemic transformation of MDS...
  7. doi request reprint BAALC-associated gene expression profiles define IGFBP7 as a novel molecular marker in acute leukemia
    S Heesch
    Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Medizinische Klinik III, Berlin, Germany
    Leukemia 24:1429-36. 2010
    ..In contrast to BAALC, which likely represents only a surrogate marker of treatment failure in acute leukemia, IGFBP7 regulates the proliferation of leukemic cells and might be involved in chemotherapy resistance...
  8. doi request reprint Survival, prognostic factors and rates of leukemic transformation in 381 untreated patients with MDS and del(5q): a multicenter study
    U Germing
    Department of Hematology, Oncology and Clinical Immunology, Heinrich Heine University Dusseldorf, Dusseldorf, Germany
    Leukemia 26:1286-92. 2012
    ..In conclusion, patients with MDS and del(5q) are facing a considerable risk of AML transformation. More detailed cytogenetic and molecular studies may help to identify the patients at risk of progression...
  9. doi request reprint Genome-wide screen reveals WNT11, a non-canonical WNT gene, as a direct target of ETS transcription factor ERG
    L H Mochmann
    Department of Hematology and Oncology, Charite, Campus Benjamin Franklin, Berlin, Germany
    Oncogene 30:2044-56. 2011
    ..The findings in this study unravel new ERG-directed molecular signals that may contribute to the resistance of current therapies in acute leukemia patients with poor prognosis characterized by high ERG mRNA expression...
  10. ncbi request reprint Transcriptional profiling of human hematopoiesis during in vitro lineage-specific differentiation
    Martina Komor
    Department of Hematology, Oncology and Transfusion Medicine, University Hospital Benjamin Franklin, Hindenburgdamm 30, 12203 Berlin, Germany
    Stem Cells 23:1154-69. 2005
    ..The expression of selected genes was confirmed by real-time polymerase chain reaction. Our data encompass the first extensive transcriptional profile of human hematopoiesis during in vitro lineage-specific differentiation...
  11. pmc Transcription profiling of C/EBP targets identifies Per2 as a gene implicated in myeloid leukemia
    Sigal Gery
    Cedars Sinai Medical Center, Davis Bldg 5066, 8700 Beverly Blvd, Los Angeles, CA 90048, USA
    Blood 106:2827-36. 2005
    ..These results suggest that Per2 is a downstream C/EBPalpha-target gene involved in AML, and its disruption might be involved in initiation and/or progression of AML...
  12. ncbi request reprint Detection of aberrant gene expression in CD34+ hematopoietic stem cells from patients with agnogenic myeloid metaplasia using oligonucleotide microarrays
    Letetia C Jones
    Division of Laboratory Medicine, University of California, 513 Parnassus Ave S864, San Francisco, California 94143, USA
    Stem Cells 23:631-7. 2005
    ..Our results indicate that a subset of genes may be used to differentiate patients with AMM from healthy individuals. Furthermore, we identify 95 genes whose aberrant expression may be involved in AMM...
  13. ncbi request reprint C/EBPdelta expression in a BCR-ABL-positive cell line induces growth arrest and myeloid differentiation
    Sigal Gery
    Cedars Sinai Medical Center, Division of Hematology Oncology, UCLA School of Medicine, Los Angeles, CA 90048, USA
    Oncogene 24:1589-97. 2005
    ....
  14. ncbi request reprint Characterization of gene expression of CD34+ cells from normal and myelodysplastic bone marrow
    Wolf K Hofmann
    Division of Hematology Oncology, Cedars Sinai Research Institute, Los Angeles, CA, USA
    Blood 100:3553-60. 2002
    ..Furthermore, this study provides evidence that in MDS, hematopoietic stem cells accumulate defects that prevent normal hematopoiesis...
  15. ncbi request reprint Ph(+) acute lymphoblastic leukemia resistant to the tyrosine kinase inhibitor STI571 has a unique BCR-ABL gene mutation
    Wolf K Hofmann
    Division of Hematology Oncology, Cedars Sinai Research Institute, UCLA School of Medicine, Los Angeles, California 90048, USA
    Blood 99:1860-2. 2002
    ..Glu255Lys is within the motif important for forming the pocket of the ATP-binding site in ABL and it is highly conserved across species. In conclusion, Ph(+) ALL samples resistant to STI571 have a unique mutation Glu255Lys of BCR-ABL...
  16. ncbi request reprint Expression of C/EBPbeta from the C/ebpalpha gene locus is sufficient for normal hematopoiesis in vivo
    Letetia C Jones
    Division of Hematology and Oncology, Cedars Sinai Medical Center, UCLA School of Medicine, 8700 Beverly Blvd, Rm 109, Los Angeles, CA 90048, USA
    Blood 99:2032-6. 2002
    ..These results imply that C/EBPbeta can substitute for C/EBPalpha during hematopoiesis when expressed from the C/ebpalpha gene locus...
  17. ncbi request reprint C/EBP-beta, C/EBP-delta, PU.1, AML1 genes: mutational analysis in 381 samples of hematopoietic and solid malignancies
    Vijaya Vegesna
    Division of Hematology Oncology, Cedars Sinai Research Institute, UCLA School of Medicine, Los Angeles, CA 90048, USA
    Leuk Res 26:451-7. 2002
    ..The C/EBP-delta alteration in Raji was a missense mutation (A177G). These findings suggest that mutations of the C/EBP-beta, C/EBP-delta, PU.1, and AML1 rarely contribute to the development of hematopoietic or solid cancers...
  18. ncbi request reprint Differentiation therapy for myelodysplastic syndrome
    Wolf K Hofmann
    Clin Cancer Res 8:939-41. 2002
  19. pmc Disruption of LTBP-4 function reduces TGF-beta activation and enhances BMP-4 signaling in the lung
    Katri Koli
    Department of Virology, Haartman Institute and Helsinki University Hospital, University of Helsinki, 00014 Helsinki, Finland
    J Cell Biol 167:123-33. 2004
    ..Treatment with active TGF-beta1 rescued BMP-4 and gremlin expression to wild-type levels. Our results indicate that the lack of LTBP-4-mediated targeting and activation of TGF-beta1 leads to enhanced BMP-4 signaling in mouse lung...
  20. pmc RTP801 is a novel retinoic acid-responsive gene associated with myeloid differentiation
    Sigal Gery
    Division of Hematology Oncology, UCLA School of Medicine, Cedars Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, CA 90048, USA
    Exp Hematol 35:572-8. 2007
    ..The aim of this study was to identify and characterize retinoic acid (RA) target genes...
  21. ncbi request reprint Altered apoptosis pathways in mantle cell lymphoma
    Mathias J Rummel
    Departament of Hematology, University Hospital, Frankfurt Main, Germany
    Leuk Lymphoma 45:49-54. 2004
    ....
  22. ncbi request reprint Mechanisms of resistance to STI571 (Imatinib) in Philadelphia-chromosome positive acute lymphoblastic leukemia
    Wolf K Hofmann
    Department of Hematology and Oncology, University Hospital, Frankfurt Main, Germany
    Leuk Lymphoma 45:655-60. 2004
    ..This may result in the proliferation of Ph + leukemic cells even in the presence of STI571...
  23. ncbi request reprint RARbeta2 is a candidate tumor suppressor gene in myelofibrosis with myeloid metaplasia
    Letetia C Jones
    Division of Hematology Oncology, Department of Medicine, Cedars Sinai Medical Center, UCLA School of Medicine, Los Angeles, CA 90048, USA
    Oncogene 23:7846-53. 2004
    ..Our results suggest that RARbeta2 acts as a tumor suppressor gene in MMM and that epigenetic changes are the most significant determinants of RARbeta2 gene activity in these patients...
  24. ncbi request reprint Mutations in the gene encoding the transcription factor CCAAT/enhancer binding protein alpha in myelodysplastic syndromes and acute myeloid leukemias
    Adrian F Gombart
    Cedars Sinai Medical Center, Burns and Allen Research Institute, Division of Hematology Oncology, University of California Los Angeles School of Medicine, 90048, USA
    Blood 99:1332-40. 2002
    ..These results suggest that mutation of C/EBPalpha is involved in specific subtypes of AML and in MDS, but may occur rarely in other types of leukemias or nonhematologic malignancies...