Research Topics
| Bert HildebrandtSummaryAffiliation: Humboldt University Country: Germany Publications
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Publications
Current status of radiant whole-body hyperthermia at temperatures >41.5 degrees C and practical guidelines for the treatment of adults. The German 'Interdisciplinary Working Group on Hyperthermia'B Hildebrandt
Medizinische Klink für Hämatologie und Onkologie, Campus Virchow Klinikum, Charite Universitatsmedizin Berlin, Augustenburger Platz 1, D 13353 Berlin, Germany
Int J Hyperthermia 21:169-83. 2005..These recommendations may be helpful to ensure the quality of WBH performed at different institutions...
Treatment of locally recurrent rectal cancer with special focus on regional pelvic hyperthermiaB Hildebrandt
Medizinische Klinik mit Schwerpunkt Hämatologie und Onkologie, Campus Virchow Klinikum, Charite Universitatsmedizin Berlin, Germany
Onkologie 27:506-11. 2004..Here we give a short overview on the options available for the treatment of pelvic recurrence of rectal cancer, with special focus on adjunctive regional pelvic radiofrequency hyperthermia...
Whole-body hyperthermia in the scope of von Ardenne's systemic cancer multistep therapy (sCMT) combined with chemotherapy in patients with metastatic colorectal cancer: a phase I/II studyB Hildebrandt
Medizinische Klinik für Hämatologie und Onkologie, Universitätklinikum Charité, Berlin, Germany
Int J Hyperthermia 20:317-33. 2004..The fact that three patients who did not respond to initial chemotherapy achieved a PR after additional sCMT suggests that sCMT may enhance the effect of chemotherapy in patients with colorectal cancer...
Regional pelvic hyperthermia as an adjunct to chemotherapy (oxaliplatin, folinic acid, 5-fluorouracil) in pre-irradiated patients with locally recurrent rectal cancer: a pilot studyB Hildebrandt
Medizinische Klinik mit Schwerpunkt Hämatologie und Onkologie, Campus Virchow Klinikum, Charite Universitatsmedizin Berlin, Augustenburger Platz 1, D 13353 Berlin, Germany
Int J Hyperthermia 20:359-69. 2004..Overall toxicity was moderate, although hyperthermia may add side-effects to this approach. Results, moreover, suggest a relevant palliative effect in patients with pre-irradiated pelvic recurrence of rectal cancer...
[Standards and perspectives in locoregional hyperthermia]Bert Hildebrandt
Medizinische Klinik für Hämatologie und Onkologie, Campus Virchow Klinikum, Charite Universitatsmedizin Berlin, Berlin, Deutschland
Wien Med Wochenschr 154:148-58. 2004..We here give a critical update on the proven indications of the different locoregional hyperthermia approaches and on the current clinical and technological progress in this field...
Adjuvant chemotherapy with folinic acid and 5-fluorouracil in patients with locally advanced rectal cancer previously treated by preoperative radiochemotherapy and curative tumor resectionBert Hildebrandt
Medizinische Klinik für Hämatologie und Onkologie, Charite, Campus Virchow Klinikum, Augustenburger Platz 1, 13353 Berlin, Germany
Int J Colorectal Dis 21:582-9. 2006..The role of postoperative adjuvant chemotherapy in patients with rectal cancer pretreated by preoperative radiochemotherapy (RCT) and curative surgery is still poorly investigated...
Differential gene expression in peripheral blood lymphocytes of cancer patients treated with whole body hyperthermia and chemotherapy: a pilot studyBert Hildebrandt
Medizinische Klinik mit Schwerpunkt Hämatologie und Onkologie, Campus Virchow Klinikum, Charité Universitätsmedizin Berlin der Humboldt Universität, Berlin, Germany
Int J Hyperthermia 22:625-35. 2006..The aim of this study was to identify genes that become upregulated in peripheral blood lymphocytes (PBLs) of cancer patients during a combined treatment with WBH and chemotherapy by generating complex arrays of cDNA...
Interventionally implanted port catheter systems for hepatic arterial infusion of chemotherapy in patients with colorectal liver metastases: a Phase II-study and historical comparison with the surgical approachBert Hildebrandt
CharitéCentrum fur Tumormedizin, Medizinische Klinik mit Schwerpunkt Hämatologie und Onkologie, Campus Virchow Klinikum, Charite Universitatsmedizin Berlin, Berlin, Germany
BMC Cancer 7:69. 2007....
The cellular and molecular basis of hyperthermiaBert Hildebrandt
Medical Clinic, Department of Hematology and Oncology, Charite Medical School, Humboldt University, Campus Virchow Clinic, D 13344 Berlin, Germany
Crit Rev Oncol Hematol 43:33-56. 2002....
Assessment of free light chains in the cerebrospinal fluid of patients with lymphomatous meningitis - a pilot studyB Hildebrandt
Charité Centrum für Tumormedizin, Medizinische Klinik mit Schwerpunkt Hämatologie und Onkologie, Campus Virchow Klinikum, Charite Universitatsmedizin Berlin, Augustenburger Platz 1, D 13344 Berlin, Germany
BMC Cancer 7:185. 2007..Since B-cell lymphomas are clonally restricted to express either kappa or lambda immunoglobulin light chain, we hypothesised that analysis of free light chain (FLC) ratios might facilitate the diagnosis of LM...
Intraoperative fresh-frozen plasma versus human albumin in craniofacial surgery--a pilot study comparing coagulation profiles in infants younger than 12 monthsBert Hildebrandt
Medizinische Klinik m S Hämatologie und Onkologie, Campus Virchow Klinikum, Charite Universitatsmedizin Berlin, Augustenburger Platz 1, 13344 Berlin, Germany
Thromb Haemost 98:172-7. 2007..However, the course of activation markers suggested a similar extent of clotting and fibrinolytic activation with the use of both transfusion regimens, and there were no differences with regard to clinical endpoints...
Continuation of regional chemotherapy of hepatic neoplasms despite occlusion of the hepatic artery-report of four casesBert Hildebrandt
Medical Clinic for Hematology and Oncology, Campus Virchow Clinic, Charite University Hospital, 13344 Berlin, Germany
Anticancer Drugs 13:663-9. 2002..Continuation of regional chemotherapy despite hepatic arterial occlusion preserved control of intrahepatic tumor manifestations in patients who previously responded to regular HAI...
Noninvasive magnetic resonance thermography of soft tissue sarcomas during regional hyperthermia: correlation with response and direct thermometryJohanna Gellermann
Clinic for Radiation Medicine, University Hospital Charite, Campus Virchow Klinikum, Berlin, Germany
Cancer 107:1373-82. 2006..96). CONCLUSIONS: Noninvasive MR thermography of soft tissue sarcoma was feasible and suitable for validating the quality of heating during RHT...
Noninvasive magnetic resonance thermography of recurrent rectal carcinoma in a 1.5 Tesla hybrid systemJohanna Gellermann
Clinic for Radiation Medicine, , Berlin, Germany
Cancer Res 65:5872-80. 2005..Feasibility of noninvasive MR thermography for regional hyperthermia has been shown and should be further investigated...
Fusion imaging using a hybrid SPECT-CT camera improves port perfusion scintigraphy for control of hepatic arterial infusion of chemotherapy in colorectal cancer patientsTimm Denecke
Campus Virchow Klinikum, Charite Universitatsmedizin Berlin Klinik fur Strahlenheilkunde und PET Zentrum Berlin, Augustenburger Platz 1 Berlin, 13353 Berlin, Germany
Eur J Nucl Med Mol Imaging 32:1003-10. 2005..The aim of this study was to evaluate port perfusion scintigraphy in colorectal cancer patients using a hybrid SPECT-CT system for control of minimally invasive intra-arterial port systems within the scope of a phase II trial...
Genetic dissection of apoptosis and cell cycle control in response of colorectal cancer treated with preoperative radiochemotherapyIsrid Sturm
University Medical Center Charite, Campus Virchow Klinikum, Department of Hematology and Oncology, 13353 Berlin, Germany
BMC Cancer 6:124. 2006..e. 5-fluorouracil (5-FU), ionising gamma-radiation (IR) and heat shock/hyperthermia...
Stress induced changes in lymphocyte subpopulations and associated cytokines during whole body hyperthermia of 41.8-42.2 degrees COlaf Ahlers
Klinik fur Anasthesiologie und Operative Intensivmedizin, Charite Universitatsmedizin Berlin, Campus Virchow Klinikum, 13344, Berlin, Germany
Eur J Appl Physiol 95:298-306. 2005..Further studies are necessary to examine the pathophysiological details and to evaluate the meaning of these transient immunological changes for patient's outcome...
Dose-escalated conformal radiotherapy of glioblastomas -- results of a retrospective comparison applying radiation doses of 60 and 70 GyReinhold Graf
Centre of Radiation Medicine, Humboldt University, Berlin, Germany
Onkologie 28:325-30. 2005..Dose escalated three-dimensional conformal radiotherapy with 70 Gy against glioblastomas was compared retrospectively with the standard scheme of 60 Gy using 2-D-planning...
Radiochemotherapy combined with regional pelvic hyperthermia induces high response and resectability rates in patients with nonresectable cervical cancer > or =FIGO IIB "bulky"Geetha Sreenivasa
Clinic for Radiation Medicine, Campus Virchow-Klinikum, , Berlin, Germany
Int J Radiat Oncol Biol Phys 66:1159-67. 2006..Therefore, the use of hyperthermia in conjunction with standard chemo-/radiotherapy +/- surgery may allow for more effective tumor treatment while decreasing the risk of complications in patients with locally advanced cervical cancer...
Hepatic arterial port systems for treatment of liver metastases: factors affecting patency and adverse eventsJens Ricke
Department of Radiology, Charite Campus Virchow Klinikum, Humboldt University, Augustenburgerplatz 1, 13353 Berlin, Germany
J Vasc Interv Radiol 15:825-33. 2004..To assess the outcome of interventional hepatic arterial port placement in a prospective phase II trial...
A non-randomised, single-centre comparison of induction chemotherapy followed by radiochemotherapy versus concomitant chemotherapy with hyperfractionated radiotherapy in inoperable head and neck carcinomasReinhold Graf
Clinic for Radiation Medicine, Charite Medical School, Campus Virchow Klinikum, Augustenburger Platz, 113353 Berlin, Germany
BMC Cancer 6:30. 2006..The aim of this study was to compare the results of concomitant application of radiochemotherapy for treating locally advanced head-and-neck carcinoma in comparison with the former standard of sequential radiochemotherapy...
Changes in hepatic blood flow during whole body hyperthermiaMaria Deja
Department of Anaesthesiology and Intensive Care Medicine, Charite Universitatsmedizin Berlin, Germany
Int J Hyperthermia 26:95-100. 2010..The aim of this clinical study was to determine changes in hepatic blood flow during WBH for the treatment of metastatic cancer...
Cetuximab: appraisal of a novel drug against colorectal cancerBert Hildebrandt
Centrum für Tumormedizin, Medizinische Klinik mit Schwerpunkt Hämatologie und Onkologie, Charite Campus Virchow Klinikum, Berlin, Germany
Recent Results Cancer Res 176:135-43. 2007....
Planning transarterial radioembolization of colorectal liver metastases with Yttrium 90 microspheres: evaluation of a sequential diagnostic approach using radiologic and nuclear medicine imaging techniquesTimm Denecke
Klinik fur Strahlenheilkunde, Bereiche Radiologie und Nuklearmedizin, Campus Virchow Klinikum, Charite Universitatsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
Eur Radiol 18:892-902. 2008..Each part of the diagnostic algorithm showed a relevant impact on patient management. The sequential approach appears to be suitable and keeps the number of unnecessary treatments and therapy risks to a minimum...
Whole body hyperthermia induces apoptosis in subpopulations of blood lymphocytesAnnette Dieing
Medical Clinic, Department of Hematology and Oncology, Charite Medical School, Humboldt University, Campus Mitte, Berlin, Germany
Immunobiology 207:265-73. 2003..Our results suggest, that apoptosis is one reason for the previously described decrease of T-cells during WBH and of NK-cells after WBH, and that the hyperthermia-related apoptosis-inducing mechanism is different in T-cells and NK-cells...
Goal-directed therapy of cardiac preload in induced whole-body hyperthermiaMaria Deja
Department of Anesthesiology and Critical Care Medicine, Charite Medical Center, Campus Virchow Clinic, Augustenburger Platz 1, 13353 Berlin, Germany
Chest 128:580-6. 2005..To optimize volume therapy during induced whole-body hyperthermia (WBH) < or = 42.2 degrees C, pulmonary capillary wedge pressure (PCWP) and intrathoracic blood volume index (ITBVI) were compared as goal parameters...
Influence of neoadjuvant radiochemotherapy combined with hyperthermia on the quality of life in rectum cancer patientsT Schulze
Department of Surgery and Surgical Oncology, , Charit, Campus Buch, , Berlin, Germany
Int J Hyperthermia 22:301-18. 2006..The addition of hyperthermia during the neoadjuvant therapy with the potentially associated inconveniences has no negative effects on QoL...
Thermal monitoring: invasive, minimal-invasive and non-invasive approachesPeter Wust
Clinic for Radiation Medicine, Charite Medical School, Campus Virchow Klinikum, Berlin, Germany
Int J Hyperthermia 22:255-62. 2006..Invasive intra-tumoural thermometry was established as a standard method several years ago. However, in deep heating, invasive techniques have disadvantages. Therefore, alternatives have been suggested and are under development...
The effect of induced hyperthermia on the immune systemAnnette Dieing
Department of Oncology and Hematology, Charite Campus Mitte, University Medicine Berlin, Germany, Schumannstrasse 20 21, D 10117 Berlin, Germany
Prog Brain Res 162:137-52. 2007..In this chapter, we review the most relevant data known about the effect of hyperthermia on the immune system with special focus on alterations induced by therapeutical whole-body hyperthermia (WBH) in cancer patients...
Description and characterization of the novel hyperthermia- and thermoablation-system MFH 300F for clinical magnetic fluid hyperthermiaUwe Gneveckow
Department of Radiation Medicine, Charite Medical School Berlin, Campus Virchow Klinikum, Center of Biomedical Nanotechnology, Spandauer Damm 130, 14050 Berlin, Germany
Med Phys 31:1444-51. 2004..01 g/l Fe in the MRI. The system has proved its capability and practicability for heat treatment in deep regions of the human body...
Regional hyperthermia in conjunction with definitive radiotherapy against recurrent or locally advanced prostate cancer T3 pN0 M0Wolfgang Tilly
Department of Radiation Medicine, , Berlin, Germany
Strahlenther Onkol 181:35-41. 2005..CONCLUSION: Regional hyperthermia might be a low-toxicity approach to increase PSA control of common treatment schedules. Further evaluation, in particular employing improved hyperthermia technology, is worthwhile...
Response prediction by FDG-PET after neoadjuvant radiochemotherapy and combined regional hyperthermia of rectal cancer: correlation with endorectal ultrasound and histopathologyHolger Amthauer
Klinik fur Strahlenheilkunde und PET Zentrum Berlin, Campus Virchow Klinikum, Charite Universitatsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
Eur J Nucl Med Mol Imaging 31:811-9. 2004..FDG-PET results were statistically significant (P<0.001, CI=95%). FDG-PET has great potential in the assessment of tumour response to neoadjuvant RCT in combination with RHT and is superior to EUS for this purpose...
Regional hyperthermia of the abdomen in conjunction with chemotherapy for peritoneal carcinomatosis: evaluation of two annular-phased-array applicatorsC H Cho
Charite Universitatsmedizin Berlin, Clinic for Radiotherapy, Berlin, Germany
Int J Hyperthermia 24:399-408. 2008..In this phase I/II study, we evaluated regional hyperthermia of the pelvis and abdomen using the annular-phased-array technique as an adjunct to chemotherapy...
Imatinib mesylate radiosensitizes human glioblastoma cells through inhibition of platelet-derived growth factor receptorMatthias Holdhoff
, Campus Virchow, Charit, , Augustenburger Platz 1, 13353 Berlin, Germany
Blood Cells Mol Dis 34:181-5. 2005..These results suggest that imatinib may have clinical utility as a radiosensitizer in the treatment of human glioblastoma, possibly through disruption of an autocrine PDGF/PDGFR loop...
Multislice computed tomographic angiography for preinterventional planning of port placement for intra-arterial hepatic infusion chemotherapyLukas Lehmkuhl
Clinic of Radiology, Nuclear Medicine and Radiation Oncology, Charite University Medicine Berlin, Germany
J Comput Assist Tomogr 31:66-71. 2007..To determine the impact of preinterventional multislice computed tomographic angiography (MSCTA) on the interventional management of patients scheduled for hepatic port placement...
Impact of overall treatment time on local control of anal cancer treated with radiochemotherapyR Graf
Center of Radiation Medicine, Campus Virchow Clinic, , Humboldt University, Berlin, Germany
Oncology 65:14-22. 2003....
Interactions between hyperthermia and cytotoxic drugsB Hildebrandt
Charité Centrum Tumormedizin, Charite Universitatsmedizin Berlin, Germany
Cancer Treat Res 134:185-93. 2007....
Anaesthesiological experiences with whole body hyperthermiaT Kerner
Department of Anaesthesiology and Critical Care Medicine, Charite Medical Center, Virchow Hospital, Humboldt University, D 13344 Berlin, Germany
Int J Hyperthermia 19:1-12. 2003....
[Radiological-guided liver-port implantation: Evaluation, technical approach, interventional procedure and follow up]R Puls
Klinik fur Strahlenheilkunde, Campus Virchow Klinikum, Germany
Rofo 173:914-9. 2001..Radiological-guided liver-port implantation: Evaluation, technical approach, interventional procedure and follow up...
Assessment of local control after laser-induced thermotherapy of liver metastases from colorectal cancer: contribution of FDG-PET in patients with clinical suspicion of progressive diseaseT Denecke
Klinik fur Strahlenheilkunde, Bereiche Radiologie und Nuklearmedizin, Medizinische Klinik mit Schwerpunkt Hämatologie Onkologie, Campus Virchow Klinikum, Charite Universitatsmedizin Berlin, Germany
Acta Radiol 48:821-30. 2007....
Feasibility and analysis of thermal parameters for the whole-body-hyperthermia system IRATHERM-2000P Wust
Department of Radiation Medicine, Charite Medical Center, Berlin, Germany
Int J Hyperthermia 16:325-39. 2000..In the authors' opinion, improved understanding of the mechanisms and crucial parameters underlying whole body hyperthermia, will enable a controllable and tolerable therapy through proficient contribution to equipment and methods...
A clinical pilot study of fresh frozen plasma versus human albumin in paediatric craniofacial repairT Kerner
Clinic for Anaesthesiology and Intensive Care Medicine, Charité Centrum 07 for Anaesthesiology, OP Management and Intensive Care Medicine, Charite University Hospital, Berlin, Germany
J Int Med Res 36:171-7. 2008..Volume replacement during pCFS can be safely performed with both applied protocols. Our data do not demonstrate a major advantage for FFP use, but further evaluation is necessary...
Comparison of CT, MRI and FDG-PET in response prediction of patients with locally advanced rectal cancer after multimodal preoperative therapy: is there a benefit in using functional imaging?T Denecke
Klinik für Strahlenheilkunde und PET Zentrum Berlin Campus Virchow Klinikum, Charite Universitatsmedizin Berlin, Augustenburger Platz 1, Berlin, 13353, Germany
Eur Radiol 15:1658-66. 2005..002, CT P=0.197, MRI P=0.500). These results suggest that FDG-PET is superior to CT and MRI in predicting response to preoperative multimodal treatment of locally advanced primary rectal cancer...
The biologic rationale of hyperthermiaB Hildebrandt
Charité Centrum Tumormedizin, Charite Universitatsmedizin Berlin, Germany
Cancer Treat Res 134:171-84. 2007....
Monitoring arterial blood pressure during whole body hyperthermiaT Kerner
Department of Anesthesiology and Critical Care Medicine, Charite Medical Center, Virchow Hospital, Humboldt University, Berlin
Acta Anaesthesiol Scand 46:561-6. 2002..This investigation was performed to evaluate the agreement of invasive measurements at various sites, and to compare invasive and non-invasive methods of ABP monitoring under conditions of a heat-induced extreme vasodilation...
Hyperthermia in combined treatment of cancerP Wust
Department of Radiation Oncology, Charite Medical School, Campus Virchow Klinikum, Berlin, Germany
Lancet Oncol 3:487-97. 2002..However, for every particular temperature-dependent interaction exploited for clinical purposes, sophisticated control of temperature, spatially as well as temporally, in deep body regions will further improve the potential...
Intraperitoneal distribution of ultrasound contrast medium imaged with B-mode ultrasound and colour-stimulated acoustic emission imagingR Puls
Institut fur Radiologie, Campus Charite Mitte, Humboldt Universitat, Schumannstrasse 20 21, 10098 Berlin, Germany
Eur Radiol 13:695-9. 2003..This method is therefore well suited for imaging port catheter systems prior to chemotherapy...
Evaluation of patients with liver metastases from colorectal cancer for locally ablative treatment with laser induced thermotherapy. Impact of PET with 18F-fluorodeoxyglucose on therapeutic decisionsH Amthauer
Klinik fur Strahlenheilkunde, Charite Universitatsmedizin, Augustenburger Platz 1, 13353 Berlin, Germany
Nuklearmedizin 45:177-84. 2006..In this study we determined the value of FDG-PET in comparison to conventional staging procedures...
[Part-body hyperthermia with a radiofrequency multiantenna applicator under online control in a 1.5 T MR-tomograph]P Wust
Charite, Klinik fur Strahlenheilkunde, Berlin
Rofo 176:363-74. 2004..The -hybrid approach renders development of part body hyperthermia possible as an MR-controlled intervention in radiology...
Repetitive transarterial chemoembolization (rTACE) of hepatocellular carcinoma: comparisons between an arterial port system and conventional angiographic techniqueNico Hidajat
Department of Radiology, Charite, Virchow Clinic of the Humboldt University Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
Eur J Radiol 51:6-11. 2004..To compare the cost and radiation exposure of repetitive transarterial chemoembolization (rTACE) using percutaneously implantable port system with rTACE using conventional catheterization technique...
Effective use of high-dose chemotherapy and autologous stem cell rescue for relapsed adult Wilms' tumor and a novel alteration in intron 1 of the WT1 geneRalf Ulrich Trappe
Department of Hematology and Oncology, Charite University Hospital Berlin, Campus Virchow Klinikum, Augustenburger Platz 1, D 13353 Berlin, Germany
J Pediatr Hematol Oncol 26:820-3. 2004..Both chemotherapy regimens showed moderate treatment-related toxicity. This report is the first that indicates that adult nephroblastoma patients also may carry WT1 germline mutations...
Methods and potentials of magnetic resonance imaging for monitoring radiofrequency hyperthermia in a hybrid systemJ Gellermann
Department of Radiation Medicine, Charite Medical School, Berlin, Germany
Int J Hyperthermia 21:497-513. 2005..A hybridization of an MRI scanner with a hyperthermia system is necessary for a real-time NIT. The selection of the best thermographic method is difficult, because many parameters and attributes have to be considered...
5-fluorouracil, folinic acid and oxaliplatin administered via hepatic arterial infusion as regional second-line therapy for advanced colorectal cancerLars Meyer
Oncology 64:473-4. 2003
Hyperthermic intraperitoneal chemotherapy in patients with peritoneal carcinosisBert Hildebrandt
J Clin Oncol 22:1527-9; author reply 1529. 2004
