Thomas Harder

Summary

Affiliation: Humboldt University
Country: Germany

Publications

  1. ncbi Overweight and increased diabetes susceptibility in neonatally insulin-treated adult rats
    T Harder
    Institute of Experimental Endocrinology, Humboldt University Medical School Charit, Berlin, Germany
    Endocr Regul 33:25-31. 1999
  2. ncbi Duration of breastfeeding and risk of overweight: a meta-analysis
    Thomas Harder
    Clinic of Obstetrics, Division of Experimental Obstetrics, Charite University Medicine, Berlin, Germany
    Am J Epidemiol 162:397-403. 2005
  3. doi Birth weight and subsequent risk of childhood primary brain tumors: a meta-analysis
    Thomas Harder
    Clinic of Obstetrics, Research Group Experimental Obstetrics, Charite Universitatsmedizin Berlin, Campus Virchow Klinikum, Berlin, Germany
    Am J Epidemiol 168:366-73. 2008
  4. ncbi Birth weight and risk of neuroblastoma: a meta-analysis
    Thomas Harder
    Clinic of Obstetrics, Division of Experimental Obstetrics, Charite Universitatsmedizin Berlin, Berlin, Germany
    Int J Epidemiol 39:746-56. 2010
  5. doi Epigenetic malprogramming of the insulin receptor promoter due to developmental overfeeding
    Andreas Plagemann
    Division of Experimental Obstetrics, Clinic of Obstetrics, Charite University Medicine Berlin, Campus Virchow Klinikum, Berlin, Germany
    J Perinat Med 38:393-400. 2010
  6. ncbi 'Programming' of orexigenic and anorexigenic hypothalamic neurons in offspring of treated and untreated diabetic mother rats
    Kerstin Franke
    Clinic of Obstetrics, Division of Experimental Obstetrics, Charite University Medicine Berlin, Campus Virchow Klinikum, Augustenburger Platz 1, 13353 Berlin, Germany
    Brain Res 1031:276-83. 2005
  7. ncbi Long-term impact of breast-feeding on body weight and glucose tolerance in children of diabetic mothers: role of the late neonatal period and early infancy
    Elke Rodekamp
    Clinic of Obstetrics, Head of Experimental Obstetrics, Charite University Medicine Berlin, Campus Virchow Klinikum, Augustenburgerplatz 1, 13353 Berlin, Germany
    Diabetes Care 28:1457-62. 2005
  8. pmc Hypothalamic proopiomelanocortin promoter methylation becomes altered by early overfeeding: an epigenetic model of obesity and the metabolic syndrome
    Andreas Plagemann
    Clinic of Obstetrics, Research Group Experimental Obstetrics, Charite University Medicine Berlin, Campus Virchow Klinikum, Berlin, Germany
    J Physiol 587:4963-76. 2009
  9. ncbi Impact of breast-feeding on psychomotor and neuropsychological development in children of diabetic mothers: role of the late neonatal period
    Elke Rodekamp
    Clinic of Obstetrics, Research Groups Experimental Obstetrics, Charite University Medicine Berlin, Germany
    J Perinat Med 34:490-6. 2006
  10. ncbi Impact of early neonatal breast-feeding on psychomotor and neuropsychological development in children of diabetic mothers
    Andreas Plagemann
    Clinic of Obstetrics, Division of Experimental Obstetrics, Charite University Medicine Berlin, Campus Virchow Klinikum, Berlin, Germany
    Diabetes Care 28:573-8. 2005

Collaborators

Detail Information

Publications38

  1. ncbi Overweight and increased diabetes susceptibility in neonatally insulin-treated adult rats
    T Harder
    Institute of Experimental Endocrinology, Humboldt University Medical School Charit, Berlin, Germany
    Endocr Regul 33:25-31. 1999
    ....
  2. ncbi Duration of breastfeeding and risk of overweight: a meta-analysis
    Thomas Harder
    Clinic of Obstetrics, Division of Experimental Obstetrics, Charite University Medicine, Berlin, Germany
    Am J Epidemiol 162:397-403. 2005
    ..94, 0.98). The definitions of overweight and age had no influence. These findings strongly support a dose-dependent association between longer duration of breastfeeding and decrease in risk of overweight...
  3. doi Birth weight and subsequent risk of childhood primary brain tumors: a meta-analysis
    Thomas Harder
    Clinic of Obstetrics, Research Group Experimental Obstetrics, Charite Universitatsmedizin Berlin, Campus Virchow Klinikum, Berlin, Germany
    Am J Epidemiol 168:366-73. 2008
    ..60). No association was found for ependymoma. These findings indicate that birth weight is related to the development of childhood brain tumors, with high birth weight being a risk factor for the two most common types of brain tumors...
  4. ncbi Birth weight and risk of neuroblastoma: a meta-analysis
    Thomas Harder
    Clinic of Obstetrics, Division of Experimental Obstetrics, Charite Universitatsmedizin Berlin, Berlin, Germany
    Int J Epidemiol 39:746-56. 2010
    ..Previous studies investigated whether birth weight is associated with risk of neuroblastoma, with conflictive results. We conducted a meta-analysis to quantitatively summarize the published evidence...
  5. doi Epigenetic malprogramming of the insulin receptor promoter due to developmental overfeeding
    Andreas Plagemann
    Division of Experimental Obstetrics, Clinic of Obstetrics, Charite University Medicine Berlin, Campus Virchow Klinikum, Berlin, Germany
    J Perinat Med 38:393-400. 2010
    ..g., due to induction of hypothalamic insulin resistance. We investigated acquired alterations of the DNA methylation pattern of the hypothalamic insulin receptor promoter (IRP) which might be an underlying molecular mechanism...
  6. ncbi 'Programming' of orexigenic and anorexigenic hypothalamic neurons in offspring of treated and untreated diabetic mother rats
    Kerstin Franke
    Clinic of Obstetrics, Division of Experimental Obstetrics, Charite University Medicine Berlin, Campus Virchow Klinikum, Augustenburger Platz 1, 13353 Berlin, Germany
    Brain Res 1031:276-83. 2005
    ..These acquired alterations are preventable by treatment of maternal GD...
  7. ncbi Long-term impact of breast-feeding on body weight and glucose tolerance in children of diabetic mothers: role of the late neonatal period and early infancy
    Elke Rodekamp
    Clinic of Obstetrics, Head of Experimental Obstetrics, Charite University Medicine Berlin, Campus Virchow Klinikum, Augustenburgerplatz 1, 13353 Berlin, Germany
    Diabetes Care 28:1457-62. 2005
    ..Here, we investigate whether DBM intake during the late neonatal period and early infancy also influences later adipogenic and diabetogenic risk in ODM...
  8. pmc Hypothalamic proopiomelanocortin promoter methylation becomes altered by early overfeeding: an epigenetic model of obesity and the metabolic syndrome
    Andreas Plagemann
    Clinic of Obstetrics, Research Group Experimental Obstetrics, Charite University Medicine Berlin, Campus Virchow Klinikum, Berlin, Germany
    J Physiol 587:4963-76. 2009
    ..Our findings reveal overfeeding as an epigenetic risk factor of obesity programming and consecutive diabetic and cardiovascular disorders and diseases, in terms of the metabolic syndrome...
  9. ncbi Impact of breast-feeding on psychomotor and neuropsychological development in children of diabetic mothers: role of the late neonatal period
    Elke Rodekamp
    Clinic of Obstetrics, Research Groups Experimental Obstetrics, Charite University Medicine Berlin, Germany
    J Perinat Med 34:490-6. 2006
    ..Late neonatal DBM ingestion (2nd-4th week), however, not independently influenced the risk of overweight. We investigated whether late neonatal DBM ingestion might independently influence neuro-development...
  10. ncbi Impact of early neonatal breast-feeding on psychomotor and neuropsychological development in children of diabetic mothers
    Andreas Plagemann
    Clinic of Obstetrics, Division of Experimental Obstetrics, Charite University Medicine Berlin, Campus Virchow Klinikum, Berlin, Germany
    Diabetes Care 28:573-8. 2005
    ..Here, we investigated the influence of early neonatal intake of DBM on neurodevelopment in ODM...
  11. doi Early postnatal life as a critical time window for determination of long-term metabolic health
    Andreas Plagemann
    Division of Experimental Obstetrics, Clinic of Obstetrics, Charite Universitatsmedizin Berlin, Campus Virchow Klinikum, Berlin, Germany
    Best Pract Res Clin Endocrinol Metab 26:641-53. 2012
    ..This opens a variety of opportunities and challenges to primarily prevent chronic diseases, e.g. the metabolic syndrome...
  12. doi Birth weight, early weight gain, and subsequent risk of type 1 diabetes: systematic review and meta-analysis
    Thomas Harder
    Clinic of Obstetrics, Division of Experimental Obstetrics, Charite Universitatsmedizin Berlin, Berlin, Germany
    Am J Epidemiol 169:1428-36. 2009
    ..This meta-analysis indicates that high birth weight and increased early weight gain are risk factors for type 1 diabetes...
  13. doi Short-term regulation of the hypothalamic melanocortinergic system under fasting and defined glucose-refeeding conditions in rats: a laser capture microdissection (LMD)-based study
    Emelie M Landmann
    Clinic of Obstetrics, Research Group Experimental Obstetrics, Charite Universitatsmedizin Berlin, Berlin, Germany
    Neurosci Lett 515:87-91. 2012
    ..Findings suggest that POMC in ARC neurons acts glucose-mediated as an "anti-orexigenic" neurohormone, specifically responding to hyperglycemia...
  14. ncbi Cross-fostering to diabetic rat dams affects early development of mediobasal hypothalamic nuclei regulating food intake, body weight, and metabolism
    Sonja Fahrenkrog
    Clinic of Obstetrics, Division of Experimental Obstetrics, Charite University Medicine Berlin, Campus Virchow Klinikum, Berlin, Germany
    J Nutr 134:648-54. 2004
    ....
  15. doi Rapid neonatal weight gain increases risk of childhood overweight in offspring of diabetic mothers
    Andreas Plagemann
    Clinic of Obstetrics, Division of Experimental Obstetrics, Charite, University Medicine Berlin, Campus Virchow Klinikum, Berlin, Germany
    J Perinat Med 40:557-63. 2012
    ..However, the role of early postnatal weight gain for later overweight has not been addressed so far in ODM. We investigated whether increased weight gain during the first 4 months is related to later overweight in ODM...
  16. ncbi Independent association between leptin and blood pressure during third trimester in normal and gestational diabetic pregnancies
    Kai J Buhling
    Clinic of Obstetrics, Campus Virchow Klinikum, Charite University Medicine Berlin, Humboldt University, Augustenburger Platz 1, D 13353 Berlin, Germany
    Eur J Obstet Gynecol Reprod Biol 119:180-4. 2005
    ..To assess the relationship between plasma leptin concentration during third trimester of pregnancy and blood pressure, independent of body mass index at examination and other potential confounders...
  17. ncbi Long-term impact of neonatal breast-feeding on body weight and glucose tolerance in children of diabetic mothers
    Andreas Plagemann
    Institute of Experimental Endocrinology, Humboldt University Medical School Charité, Berlin, Germany
    Diabetes Care 25:16-22. 2002
    ..In population-based studies, breast-feeding has been shown to be protective against obesity and diabetes later in life. To date, the role of breast-feeding on offspring of diabetic mothers (ODM) has not been investigated in this context...
  18. ncbi Prevention by maternal pancreatic islet transplantation of hypothalamic malformation in offspring of diabetic mother rats is already detectable at weaning
    Thomas Harder
    Clinic of Obstetrics, Division of Experimental Obstetrics, Humboldt University Medical School Charité, Campus Virchow Klinikum, Augustenburger Platz 1, 13353, Berlin, Germany
    Neurosci Lett 352:163-6. 2003
    ..In conclusion, prevention of VMN malformation in offspring of islet-transplanted diabetic mothers is a direct consequence of normalized maternal metabolism during critical perinatal development...
  19. doi Monozygotic twins with neurofibromatosis type 1 (NF1) display differences in methylation of NF1 gene promoter elements, 5' untranslated region, exon and intron 1
    Anja Harder
    Department of Neuropathology, Charite Universitatsmedizin Berlin, Germany
    Twin Res Hum Genet 13:582-94. 2010
    ..The results point towards a role of methylation patterns of the normal NF1 allele for expression differences and for modification of the NF1 phenotype...
  20. doi [Fetal programming by disturbed intrauterine environment - fundamental mechanisms exemplified by the regulation of body weight and metabolism]
    Andreas Plagemann
    Arbeitsgruppe Experimentelle Geburtsmedizin, Klinik fur Geburtsmedizin, Campus Virchow Klinikum, Charite Universitatsmedizin Berlin, Berlin, Deutschland
    Gynakol Geburtshilfliche Rundsch 48:215-24. 2008
    ..The resultant far-reaching potential for primary prevention of chronic diseases as well as the paradigmatic character of these hypotheses and observations for the general understanding of health and disease are highlighted...
  21. pmc Birth weight and long-term overweight risk: systematic review and a meta-analysis including 643,902 persons from 66 studies and 26 countries globally
    Karen Schellong
    Clinic of Obstetrics, Division of Experimental Obstetrics, Charite University Medicine Berlin, Campus Virchow Klinikum, Berlin, Germany
    PLoS ONE 7:e47776. 2012
    ..In order to check this important assumption of developmental and preventive medicine, we performed a systematic review and comprehensive meta-analysis...
  22. ncbi No influence of high- and low-carbohydrate diet on the oral glucose tolerance test in pregnancy
    Kai J Buhling
    Clinic of Obstetrics, Charite Campus Virchow Klinikum, Humboldt University, D 13353 Berlin, Germany
    Clin Biochem 37:323-7. 2004
    ....
  23. doi Intrauterine growth restriction and developmental programming of the metabolic syndrome: a critical appraisal
    Uta Neitzke
    Clinic of Obstetrics, Division of Experimental Obstetrics, Charite University Medicine Berlin, Berlin, Germany
    Microcirculation 18:304-11. 2011
    ..From a clinical point of view, prevention of causes of IUGR, as well as avoidance of perinatal overnourishment, might be prophylactic approaches to avoid perinatal programming of cardiometabolic risks...
  24. ncbi Birth weight and subsequent risk of type 2 diabetes: a meta-analysis
    Thomas Harder
    Obstetrics Clinic, Experimental Obstetrics Research Group, Charite University Medicine Berlin, Campus Virchow Klinikum, Berlin, Germany
    Am J Epidemiol 165:849-57. 2007
    ..These findings indicate that there exists a relation between birth weight and later-life risk of type 2 diabetes which is not linearly inverse but U-shaped...
  25. pmc Differential MSH2 promoter methylation in blood cells of Neurofibromatosis type 1 (NF1) patients
    Sabrina Titze
    Department of Neuropathology, Charite Universitatsmedizin Berlin, Berlin 10117, Germany
    Eur J Hum Genet 18:81-7. 2010
    ..Our results may point toward a role of MSH2 as a modifier for NF1, although the amount of DNA methylation and subsequent gene expression in other cell types of NF1 patients needs to be elucidated...
  26. ncbi Letter by Harder et al regarding article, "Low birth weight, a risk factor for cardiovascular diseases in later life, is already associated with elevated fetal glycosylated hemoglobin at birth"
    Thomas Harder
    Circulation 115:e462; author reply e463-4. 2007
  27. ncbi Infant weight gain and later blood pressure
    Thomas Harder
    Circulation 106:e58; author reply e58. 2002
  28. ncbi Birth weight and parental BMI predict overweight in children from mothers with gestational diabetes
    Ute M Schaefer-Graf
    Department of Obstetrics, Vivantes Medical Center Berlin Neukölln, Rudower Strasse 48, D 12351 Berlin, Germany
    Diabetes Care 28:1745-50. 2005
    ..To investigate the growth of children from pregnancies with gestational diabetes mellitus (GDM) and its association with antenatal maternal, fetal, and recent anthropometric parameters of mother and father...
  29. ncbi The intrauterine environmental adipogenesis
    Thomas Harder
    J Pediatr 144:551; author reply 551-2. 2004
  30. ncbi The changing face and implications of childhood obesity
    Andreas Plagemann
    N Engl J Med 350:2414-6; author reply 2414-6. 2004
  31. ncbi Birth weight and intima-media thickness
    Thomas Harder
    Epidemiology 16:421-2; author reply 422-3. 2005
  32. ncbi Re: "Association of a woman's own birth weight with her subsequent risk for pregnancy-induced hypertension"
    Thomas Harder
    Am J Epidemiol 160:507-8; author reply 508. 2004
  33. ncbi Where is the evidence that low birthweight leads to obesity?
    Thomas Harder
    Lancet 369:1859. 2007
  34. ncbi Breast-feeding and risk for childhood obesity: response to Mayer-Davis et al
    Andreas Plagemann
    Diabetes Care 30:451-2; author reply 452. 2007
  35. ncbi Low birth weight and blood pressure: the role of neonatal factors in the "small-baby-syndrome"
    Thomas Harder
    J Pediatr 146:148-9; author reply 149. 2005
  36. ncbi Premature birth and insulin resistance
    Andreas Plagemann
    N Engl J Med 352:939-40; author reply 939-40. 2005
  37. ncbi Letter regarding article by Stettler et al, "Weight gain in the first week of life and overweight in adulthood: a cohort study of European American subjects fed infant formula"
    Andreas Plagemann
    Circulation 112:e110. 2005
  38. ncbi Differences between meta-analyses on breastfeeding and obesity support causality of the association
    Thomas Harder
    Pediatrics 117:987; author reply 987-8. 2006