Research Topics
| Thomas HarderSummaryAffiliation: Humboldt University Country: Germany Publications
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Detail Information
Publications
Overweight and increased diabetes susceptibility in neonatally insulin-treated adult ratsT Harder
Institute of Experimental Endocrinology, Humboldt University Medical School Charit, Berlin, Germany
Endocr Regul 33:25-31. 1999....- Duration of breastfeeding and risk of overweight: a meta-analysisThomas Harder
Clinic of Obstetrics, Division of Experimental Obstetrics, Charite University Medicine, Berlin, Germany
Am J Epidemiol 162:397-403. 2005..94, 0.98). The definitions of overweight and age had no influence. These findings strongly support a dose-dependent association between longer duration of breastfeeding and decrease in risk of overweight... 
Birth weight and subsequent risk of childhood primary brain tumors: a meta-analysisThomas Harder
Clinic of Obstetrics, Research Group Experimental Obstetrics, Charite Universitatsmedizin Berlin, Campus Virchow Klinikum, Berlin, Germany
Am J Epidemiol 168:366-73. 2008..60). No association was found for ependymoma. These findings indicate that birth weight is related to the development of childhood brain tumors, with high birth weight being a risk factor for the two most common types of brain tumors...- Birth weight and risk of neuroblastoma: a meta-analysisThomas Harder
Clinic of Obstetrics, Division of Experimental Obstetrics, Charite Universitatsmedizin Berlin, Berlin, Germany
Int J Epidemiol 39:746-56. 2010..Previous studies investigated whether birth weight is associated with risk of neuroblastoma, with conflictive results. We conducted a meta-analysis to quantitatively summarize the published evidence... - Epigenetic malprogramming of the insulin receptor promoter due to developmental overfeedingAndreas Plagemann
Division of Experimental Obstetrics, Clinic of Obstetrics, Charite University Medicine Berlin, Campus Virchow Klinikum, Berlin, Germany
J Perinat Med 38:393-400. 2010..g., due to induction of hypothalamic insulin resistance. We investigated acquired alterations of the DNA methylation pattern of the hypothalamic insulin receptor promoter (IRP) which might be an underlying molecular mechanism... - 'Programming' of orexigenic and anorexigenic hypothalamic neurons in offspring of treated and untreated diabetic mother ratsKerstin Franke
Clinic of Obstetrics, Division of Experimental Obstetrics, , Campus Virchow-Klinikum, Augustenburger Platz 1, 13353 Berlin, Germany
Brain Res 1031:276-83. 2005..These acquired alterations are preventable by treatment of maternal GD... - Long-term impact of breast-feeding on body weight and glucose tolerance in children of diabetic mothers: role of the late neonatal period and early infancyElke Rodekamp
Clinic of Obstetrics, Head of Experimental Obstetrics, , Campus Virchow-Klinikum, Augustenburgerplatz 1, 13353 Berlin, Germany
Diabetes Care 28:1457-62. 2005..Therefore, the 1st week of life appears to be the critical window for nutritional programming in ODM by ingestion of maternal "diabetic" breast milk... 
Hypothalamic proopiomelanocortin promoter methylation becomes altered by early overfeeding: an epigenetic model of obesity and the metabolic syndromeAndreas Plagemann
Clinic of Obstetrics, Research Group Experimental Obstetrics, Charite University Medicine Berlin, Campus Virchow Klinikum, Berlin, Germany
J Physiol 587:4963-76. 2009..Our findings reveal overfeeding as an epigenetic risk factor of obesity programming and consecutive diabetic and cardiovascular disorders and diseases, in terms of the metabolic syndrome...- Impact of breast-feeding on psychomotor and neuropsychological development in children of diabetic mothers: role of the late neonatal periodElke Rodekamp
Clinic of Obstetrics, Research Groups Experimental Obstetrics, , Germany
J Perinat Med 34:490-6. 2006..Further studies are urgently recommended on consequences of breast-feeding for neurodevelopment in ODM... - Impact of early neonatal breast-feeding on psychomotor and neuropsychological development in children of diabetic mothersAndreas Plagemann
Clinic of Obstetrics, Division of Experimental Obstetrics, Charite University Medicine Berlin, Campus Virchow Klinikum, Berlin, Germany
Diabetes Care 28:573-8. 2005..Here, we investigated the influence of early neonatal intake of DBM on neurodevelopment in ODM... - Early postnatal life as a critical time window for determination of long-term metabolic healthAndreas Plagemann
Division of Experimental Obstetrics, Clinic of Obstetrics, Charite Universitatsmedizin Berlin, Campus Virchow Klinikum, Berlin, Germany
Best Pract Res Clin Endocrinol Metab 26:641-53. 2012..This opens a variety of opportunities and challenges to primarily prevent chronic diseases, e.g. the metabolic syndrome... - Birth weight, early weight gain, and subsequent risk of type 1 diabetes: systematic review and meta-analysisThomas Harder
Clinic of Obstetrics, Division of Experimental Obstetrics, Charite Universitatsmedizin Berlin, Berlin, Germany
Am J Epidemiol 169:1428-36. 2009..This meta-analysis indicates that high birth weight and increased early weight gain are risk factors for type 1 diabetes... - Short-term regulation of the hypothalamic melanocortinergic system under fasting and defined glucose-refeeding conditions in rats: a laser capture microdissection (LMD)-based studyEmelie M Landmann
Clinic of Obstetrics, Research Group Experimental Obstetrics, Charite Universitatsmedizin Berlin, Berlin, Germany
Neurosci Lett 515:87-91. 2012..Findings suggest that POMC in ARC neurons acts glucose-mediated as an "anti-orexigenic" neurohormone, specifically responding to hyperglycemia... - Cross-fostering to diabetic rat dams affects early development of mediobasal hypothalamic nuclei regulating food intake, body weight, and metabolismSonja Fahrenkrog
Clinic of Obstetrics, Division of Experimental Obstetrics, , Campus Virchow-Klinikum, Berlin, Germany
J Nutr 134:648-54. 2004.... - Rapid neonatal weight gain increases risk of childhood overweight in offspring of diabetic mothersAndreas Plagemann
Clinic of Obstetrics, Division of Experimental Obstetrics, Charite, University Medicine Berlin, Campus Virchow Klinikum, Berlin, Germany
J Perinat Med 40:557-63. 2012..However, the role of early postnatal weight gain for later overweight has not been addressed so far in ODM. We investigated whether increased weight gain during the first 4 months is related to later overweight in ODM... - Independent association between leptin and blood pressure during third trimester in normal and gestational diabetic pregnanciesKai J Buhling
Clinic of Obstetrics, Campus Virchow Klinikum, Charite University Medicine Berlin, Humboldt University, Augustenburger Platz 1, D 13353 Berlin, Germany
Eur J Obstet Gynecol Reprod Biol 119:180-4. 2005..To assess the relationship between plasma leptin concentration during third trimester of pregnancy and blood pressure, independent of body mass index at examination and other potential confounders... - Prevention by maternal pancreatic islet transplantation of hypothalamic malformation in offspring of diabetic mother rats is already detectable at weaningThomas Harder
Clinic of Obstetrics, Division of Experimental Obstetrics, Humboldt University Medical School (Charit, Campus Virchow-Klinikum, Augustenburger Platz 1, 13353, Berlin, Germany
Neurosci Lett 352:163-6. 2003..In conclusion, prevention of VMN malformation in offspring of islet-transplanted diabetic mothers is a direct consequence of normalized maternal metabolism during critical perinatal development... - Long-term impact of neonatal breast-feeding on body weight and glucose tolerance in children of diabetic mothersAndreas Plagemann
Institute of Experimental Endocrinology, Humboldt University Medical School Charité, Berlin, Germany
Diabetes Care 25:16-22. 2002..In population-based studies, breast-feeding has been shown to be protective against obesity and diabetes later in life. To date, the role of breast-feeding on offspring of diabetic mothers (ODM) has not been investigated in this context... - Monozygotic twins with neurofibromatosis type 1 (NF1) display differences in methylation of NF1 gene promoter elements, 5' untranslated region, exon and intron 1Anja Harder
Department of Neuropathology, Charite Universitatsmedizin Berlin, Germany
Twin Res Hum Genet 13:582-94. 2010..The results point towards a role of methylation patterns of the normal NF1 allele for expression differences and for modification of the NF1 phenotype... - [Fetal programming by disturbed intrauterine environment - fundamental mechanisms exemplified by the regulation of body weight and metabolism]Andreas Plagemann
Arbeitsgruppe Experimentelle Geburtsmedizin, Klinik fur Geburtsmedizin, Campus Virchow Klinikum, Charite Universitatsmedizin Berlin, Berlin, Deutschland
Gynakol Geburtshilfliche Rundsch 48:215-24. 2008..The resultant far-reaching potential for primary prevention of chronic diseases as well as the paradigmatic character of these hypotheses and observations for the general understanding of health and disease are highlighted... - No influence of high- and low-carbohydrate diet on the oral glucose tolerance test in pregnancyKai J Buhling
Clinic of Obstetrics, Charite Campus Virchow Klinikum, Humboldt University, D 13353 Berlin, Germany
Clin Biochem 37:323-7. 2004.... - Intrauterine growth restriction and developmental programming of the metabolic syndrome: a critical appraisalUta Neitzke
Clinic of Obstetrics, Division of Experimental Obstetrics, Charite University Medicine Berlin, Berlin, Germany
Microcirculation 18:304-11. 2011..From a clinical point of view, prevention of causes of IUGR, as well as avoidance of perinatal overnourishment, might be prophylactic approaches to avoid perinatal programming of cardiometabolic risks... - Birth weight and subsequent risk of type 2 diabetes: a meta-analysisThomas Harder
Obstetrics Clinic, Experimental Obstetrics Research Group, Charite University Medicine Berlin, Campus Virchow Klinikum, Berlin, Germany
Am J Epidemiol 165:849-57. 2007..These findings indicate that there exists a relation between birth weight and later-life risk of type 2 diabetes which is not linearly inverse but U-shaped... - Birth weight and long-term overweight risk: systematic review and a meta-analysis including 643,902 persons from 66 studies and 26 countries globallyKaren Schellong
Clinic of Obstetrics, Division of Experimental Obstetrics, Charite University Medicine Berlin, Campus Virchow Klinikum, Berlin, Germany
PLoS ONE 7:e47776. 2012..In order to check this important assumption of developmental and preventive medicine, we performed a systematic review and comprehensive meta-analysis... - Differential MSH2 promoter methylation in blood cells of Neurofibromatosis type 1 (NF1) patientsSabrina Titze
Department of Neuropathology, Charite Universitatsmedizin Berlin, Berlin 10117, Germany
Eur J Hum Genet 18:81-7. 2010..Our results may point toward a role of MSH2 as a modifier for NF1, although the amount of DNA methylation and subsequent gene expression in other cell types of NF1 patients needs to be elucidated... - Letter by Harder et al regarding article, "Low birth weight, a risk factor for cardiovascular diseases in later life, is already associated with elevated fetal glycosylated hemoglobin at birth"Thomas Harder
Circulation 115:e462; author reply e463-4. 2007 - Infant weight gain and later blood pressureThomas Harder
Circulation 106:e58; author reply e58. 2002 - Birth weight and parental BMI predict overweight in children from mothers with gestational diabetesUte M Schaefer-Graf
Department of Obstetrics, Vivantes Medical Center Berlin Neukölln, Rudower Strasse 48, D 12351 Berlin, Germany
Diabetes Care 28:1745-50. 2005..To investigate the growth of children from pregnancies with gestational diabetes mellitus (GDM) and its association with antenatal maternal, fetal, and recent anthropometric parameters of mother and father... - The intrauterine environmental adipogenesisThomas Harder
J Pediatr 144:551; author reply 551-2. 2004 - The changing face and implications of childhood obesityAndreas Plagemann
N Engl J Med 350:2414-6; author reply 2414-6. 2004 - Birth weight and intima-media thicknessThomas Harder
Epidemiology 16:421-2; author reply 422-3. 2005 - Re: "Association of a woman's own birth weight with her subsequent risk for pregnancy-induced hypertension"Thomas Harder
Am J Epidemiol 160:507-8; author reply 508. 2004 - Where is the evidence that low birthweight leads to obesity?Thomas Harder
Lancet 369:1859. 2007 - Breast-feeding and risk for childhood obesity: response to Mayer-Davis et alAndreas Plagemann
Diabetes Care 30:451-2; author reply 452. 2007 - Low birth weight and blood pressure: the role of neonatal factors in the "small-baby-syndrome"Thomas Harder
J Pediatr 146:148-9; author reply 149. 2005 - Premature birth and insulin resistanceAndreas Plagemann
N Engl J Med 352:939-40; author reply 939-40. 2005 - Letter regarding article by Stettler et al, "Weight gain in the first week of life and overweight in adulthood: a cohort study of European American subjects fed infant formula"Andreas Plagemann
Circulation 112:e110. 2005 - Differences between meta-analyses on breastfeeding and obesity support causality of the associationThomas Harder
Pediatrics 117:987; author reply 987-8. 2006