A Gruters

Summary

Affiliation: Humboldt University
Country: Germany

Publications

  1. ncbi request reprint Ocular manifestations in children and adolescents with thyrotoxicosis
    A Gruters
    Pediatric Endocrinology, Charité Childrens Hospital, Humboldt University, Berlin, Germany
    Exp Clin Endocrinol Diabetes 107:S172-4. 1999
  2. pmc Molecular description of non-autoimmune hyperthyroidism at a neonate caused by a new thyrotropin receptor germline mutation
    Heike Biebermann
    Institute of Experimental Paediatric Endocrinology, Charite Universitatsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
    Thyroid Res 4:S8. 2011
  3. pmc Insights into molecular properties of the human monocarboxylate transporter 8 by combining functional with structural information
    Gunnar Kleinau
    Institut für Experimentelle Pädiatrische Endokrinologie, Charite Universitatsmedizin Berlin, Germany
    Thyroid Res 4:S4. 2011
  4. ncbi request reprint Molecular genetic defects in congenital hypothyroidism
    Annette Gruters
    Paediatric Endocrinology, University Children s Hospital Charite, Augustenburger Platz 1, 13353 Berlin, Germany
    Eur J Endocrinol 151:U39-44. 2004
  5. ncbi request reprint [The pediatric-to-adult transit clinic as a quality-securing measure in endocrinological diseases]
    A Gruters
    Zentrum für Kinderheilkunde und Jugendmedizin Charité Berlin
    MMW Fortschr Med 147:29, 31-2. 2005
  6. ncbi request reprint Thyroid hormone transporter defects
    Annette Gruters
    Institute for Experimental Pediatric Endocrinology, Charite Children s Hospital, Humboldt and Free University, Berlin, Germany
    Endocr Dev 10:118-26. 2007
  7. doi request reprint Update on the management of congenital hypothyroidism
    Annette Gruters
    Charite, Institute for Experimental Pediatric Endocrinology, Berlin, Germany
    Horm Res 68:107-11. 2007
  8. ncbi request reprint Neonatal thyroid disorders
    Annette Gruters
    Department of Paediatric Endocrinology, Charite Children s Hospital, Humboldt University, Berlin, Germany
    Horm Res 59:24-9. 2003
  9. ncbi request reprint [Gene, fast food and no motion. Causes of childhood obesity]
    A Gruters
    Otto Heubner Centrum für Kinderheilkunde und Jugendmedizin, Universitatsklinikum Charite, Campus Virchow Klinikum, Augustenburger Platz 1, D 13353 Berlin
    MMW Fortschr Med 144:34-6. 2002
  10. ncbi request reprint [Characteristic features of autoimmune thyroid disease in children]
    Annette Gruters
    Institut für Pädiatrische Endokrinologie, Universitatsmedizin Berlin Charite
    Z Arztl Fortbild Qualitatssich 98:67-71. 2004

Collaborators

Detail Information

Publications40

  1. ncbi request reprint Ocular manifestations in children and adolescents with thyrotoxicosis
    A Gruters
    Pediatric Endocrinology, Charité Childrens Hospital, Humboldt University, Berlin, Germany
    Exp Clin Endocrinol Diabetes 107:S172-4. 1999
    ....
  2. pmc Molecular description of non-autoimmune hyperthyroidism at a neonate caused by a new thyrotropin receptor germline mutation
    Heike Biebermann
    Institute of Experimental Paediatric Endocrinology, Charite Universitatsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
    Thyroid Res 4:S8. 2011
    ..These mutations are mostly located in the serpentine part of this G-protein coupled receptor...
  3. pmc Insights into molecular properties of the human monocarboxylate transporter 8 by combining functional with structural information
    Gunnar Kleinau
    Institut für Experimentelle Pädiatrische Endokrinologie, Charite Universitatsmedizin Berlin, Germany
    Thyroid Res 4:S4. 2011
    ..To date, more than 25 pathogenic mutations in hMCT8 are known and they are valuable indicators of important regions for structural and functional MCT8 properties...
  4. ncbi request reprint Molecular genetic defects in congenital hypothyroidism
    Annette Gruters
    Paediatric Endocrinology, University Children s Hospital Charite, Augustenburger Platz 1, 13353 Berlin, Germany
    Eur J Endocrinol 151:U39-44. 2004
    ..However, many questions regarding the molecular defects and their consequences in the majority of patients with CH still remain open and will be addressed in this article...
  5. ncbi request reprint [The pediatric-to-adult transit clinic as a quality-securing measure in endocrinological diseases]
    A Gruters
    Zentrum für Kinderheilkunde und Jugendmedizin Charité Berlin
    MMW Fortschr Med 147:29, 31-2. 2005
    ....
  6. ncbi request reprint Thyroid hormone transporter defects
    Annette Gruters
    Institute for Experimental Pediatric Endocrinology, Charite Children s Hospital, Humboldt and Free University, Berlin, Germany
    Endocr Dev 10:118-26. 2007
    ..Indeed, thyroid function tests in patients with MCT8 mutations demonstrated marked elevations of serum T3 (in the thyrotoxic range), a significant decrease in serum T4 or fT4 and normal to elevated TSH levels...
  7. doi request reprint Update on the management of congenital hypothyroidism
    Annette Gruters
    Charite, Institute for Experimental Pediatric Endocrinology, Berlin, Germany
    Horm Res 68:107-11. 2007
    ..If hypothyroidism is confirmed by laboratory analysis, imaging studies should be performed immediately; however, it is not acceptable to delay hormone replacement therapy if imaging studies are not readily available...
  8. ncbi request reprint Neonatal thyroid disorders
    Annette Gruters
    Department of Paediatric Endocrinology, Charite Children s Hospital, Humboldt University, Berlin, Germany
    Horm Res 59:24-9. 2003
    ....
  9. ncbi request reprint [Gene, fast food and no motion. Causes of childhood obesity]
    A Gruters
    Otto Heubner Centrum für Kinderheilkunde und Jugendmedizin, Universitatsklinikum Charite, Campus Virchow Klinikum, Augustenburger Platz 1, D 13353 Berlin
    MMW Fortschr Med 144:34-6. 2002
    ..In the case of extremely overweight children, a genetic investigation would be worthwhile...
  10. ncbi request reprint [Characteristic features of autoimmune thyroid disease in children]
    Annette Gruters
    Institut für Pädiatrische Endokrinologie, Universitatsmedizin Berlin Charite
    Z Arztl Fortbild Qualitatssich 98:67-71. 2004
    ..This is why children require more time to achieve remission after anti-thyroid drug treatment. As already indicated, surgery is usually preferred to radioiodine...
  11. ncbi request reprint The first activating TSH receptor mutation in transmembrane domain 1 identified in a family with nonautoimmune hyperthyroidism
    H Biebermann
    Otto Heubner Centrum für Kinderheilkunde und Jugendmedizin, Pädiatrische Endokrinologie, Charite Campus Virchow Klinikum, Humboldt Universitat zu Berlin, Germany
    J Clin Endocrinol Metab 86:4429-33. 2001
    ....
  12. ncbi request reprint Novel mutations of the thyroid peroxidase gene in patients with permanent congenital hypothyroidism
    P Ambrugger
    Otto Heubner Zentrum für Kinder und Jugendmedizin, Pädiatrische Endokrinologie, CVK, Humboldt University, Berlin, Germany
    Eur J Endocrinol 145:19-24. 2001
    ..It is suggested that iodide organification defects account for 10% of all cases with congenital hypothyroidism (CH). One candidate gene for these defects is the thyroid peroxidase (TPO) gene...
  13. doi request reprint Association of variants in gastric inhibitory polypeptide receptor gene with impaired glucose homeostasis in obese children and adolescents from Berlin
    Jeannine Sauber
    Institute of Experimental Pediatric Endocrinology, Charite Universitatsmedizin Berlin, Berlin, Germany
    Eur J Endocrinol 163:259-64. 2010
    ..In this study, we screened the GIPR gene for mutations and examined the association between three single-nucleotide polymorphisms (SNPs; rs8111428, rs2302382, rs1800437) and childhood obesity, as well as impaired glucose homeostasis...
  14. ncbi request reprint Results of the screening program for congenital hypothyroidism in Berlin (1978-1995)
    A Gruters
    Unit for Pediatric Endocrinology, University Children s Hospital, Charite, Virchow Klinikum, Humboldt University, Berlin, Germany
    Exp Clin Endocrinol Diabetes 105:28-31. 1997
    ....
  15. ncbi request reprint Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans
    H Krude
    Department of Pediatrics, Charite, Campus Virchow, Humboldt University Berlin, Germany
    Nat Genet 19:155-7. 1998
    ..These findings represent the first examples of a genetic defect within the POMC gene and define a new monogenic endocrine disorder resulting in early-onset obesity, adrenal insufficiency and red hair pigmentation...
  16. doi request reprint A heterozygous mutation in the third transmembrane domain causes a dominant-negative effect on signalling capability of the MC4R
    Patrick Tarnow
    Department of Pediatric Endocrinology, Charite, Campus Virchow Klinikum Universitatsmedizin Berlin, Berlin, Germany
    Obes Facts 1:155-62. 2008
    ..For most MC4R mutations a gene dosage effect seems to be the underlying mechanism. However, a dominant negative effect of a heterozygous MC4R mutation was recently identified, pointing to an additional mechanism of MC4R inactivation...
  17. ncbi request reprint Impaired glucose tolerance and type 2 diabetes mellitus: a new field for pediatrics in Europe
    S Wiegand
    Paediatric Endocrinology, Charite Children s Hospital, Humboldt University, Berlin, Germany
    Int J Obes (Lond) 29:S136-42. 2005
    ..The most sensitive measurement for detecting changes in glucose metabolism in obese children seems to be an oral glucose tolerance test (OGGT) which is not practical for all daily outpatient clinics...
  18. ncbi request reprint [Who needs what? New approaches to multidisciplinary diagnostics and therapy for adipose children and youths in a multiethnic city]
    S Wiegand
    Interdisziplinäres Sozialpädiatrisches Zentrum und Institut für pädiatrische Endokrinologie und Diabetologie, CCV, Universitatsmedizin, Berlin
    Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 48:307-14. 2005
    ..Therefore, a substantial societal effort is needed to facilitate prevention for all children, and effective therapies have to be tailored depending on biological and psychosocial risk factors...
  19. ncbi request reprint [Diagnostic classification of mental disorders in infants and toddlers age 0 to 5]
    Andreas Wiefel
    Otto Heubner Centrum für Kinder und Jugendmedizin der Charité, Sozialpadiatrisches Zentrum, Berlin
    Prax Kinderpsychol Kinderpsychiatr 56:59-81. 2007
    ..The american practice parameters become adapted and a working title for diagnostic formulation is given. More research should be done against the background of the introduced standards...
  20. doi request reprint Expanded clinical spectrum in hepatocyte nuclear factor 1b-maturity-onset diabetes of the young
    Klemens Raile
    Department of Pediatric Endocrinology and Diabetes, Charite Campus Virchow, 13353 Berlin, Germany
    J Clin Endocrinol Metab 94:2658-64. 2009
    ..We aimed to investigate detailed clinical features and the type of HNF1B gene anomaly in five pediatric cases with HNF1B-MODY...
  21. pmc The spectrum of phenotypes associated with mutations in steroidogenic factor 1 (SF-1, NR5A1, Ad4BP) includes severe penoscrotal hypospadias in 46,XY males without adrenal insufficiency
    Birgit Kohler
    Developmental Endocrinology Research Group, UCL Institute of Child Health, University College London, London, UK
    Eur J Endocrinol 161:237-42. 2009
    ..We hypothesized that NR5A1 mutations could be identified in boys with hypospadias...
  22. doi request reprint Neuronal 3',3,5-triiodothyronine (T3) uptake and behavioral phenotype of mice deficient in Mct8, the neuronal T3 transporter mutated in Allan-Herndon-Dudley syndrome
    Eva K Wirth
    Neuroscience Research Center, Charite Universitatsmedizin Berlin, Berlin, Germany
    J Neurosci 29:9439-49. 2009
    ....
  23. ncbi request reprint Type 2 diabetes and impaired glucose tolerance in European children and adolescents with obesity -- a problem that is no longer restricted to minority groups
    Susanna Wiegand
    Paediatric Endocrinology, Charite Children s Hospital, Humboldt University of Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
    Eur J Endocrinol 151:199-206. 2004
    ..The incidence of childhood obesity and type 2 diabetes is an increasing problem in Europe. We determined the prevalence of impaired glucose regulation in a predominantly Caucasian cohort of 491 children and adolescents with obesity...
  24. doi request reprint Metformin and placebo therapy both improve weight management and fasting insulin in obese insulin-resistant adolescents: a prospective, placebo-controlled, randomized study
    Susanna Wiegand
    Department of Pediatric Endocrinology and Diabetology, Charite Children s Hospital, Universitatsmedizin Berlin, Augustenburger Platz 1, Berlin, Germany
    Eur J Endocrinol 163:585-92. 2010
    ..To study whether metformin reduces obesity, homeostasis model assessment for insulin resistance index (HOMA-IR), and the metabolic syndrome (MtS) in obese European adolescents in addition to previous unsuccessful lifestyle intervention...
  25. pmc Endocrine disruptors and the thyroid gland--a combined in vitro and in vivo analysis of potential new biomarkers
    Cornelia Schmutzler
    Institut für Experimentelle Endokrinologie, Charite Universitatsmedizin Berlin, Berlin, Germany
    Environ Health Perspect 115:77-83. 2007
    ..However, this is not reflected adequately in current screening and assessment procedures for endocrine activity that to date determine only general parameters of thyroid function...
  26. ncbi request reprint A role for beta-melanocyte-stimulating hormone in human body-weight regulation
    Heike Biebermann
    Institute for Pediatric Endocrinology, Charite Universitatsmedizin Berlin, 13353 Berlin, Germany
    Cell Metab 3:141-6. 2006
    ..In vitro and in vivo data as well as postmortem human brain studies indicate that the POMC-derived neuropeptide beta-MSH plays a critical role in the hypothalamic control of body weight in humans...
  27. pmc Five novel mutations in steroidogenic factor 1 (SF1, NR5A1) in 46,XY patients with severe underandrogenization but without adrenal insufficiency
    Birgit Kohler
    Department of Pediatric Endocrinology, University Children s Hospital, Charite, Humboldt University, Berlin, Germany
    Hum Mutat 29:59-64. 2008
    ..Y138X) revealed impaired transcriptional activation of SF1-responsive target genes. To date, adrenal insufficiency has not occurred in any of the patients. Thus, SF1 mutations are a relatively frequent cause of 46,XY DSD in humans...
  28. ncbi request reprint The ultraviolet filter benzophenone 2 interferes with the thyroid hormone axis in rats and is a potent in vitro inhibitor of human recombinant thyroid peroxidase
    Cornelia Schmutzler
    Institut für Experimentelle Endokrinologie, Charite Universitatsmedizin Berlin, Chariteplatz 1, D 10117 Berlin, Germany
    Endocrinology 148:2835-44. 2007
    ..This new challenge for endocrine regulation must be considered in the context of a still prevailing iodide deficiency in many parts of the world...
  29. ncbi request reprint Autosomal-dominant mode of inheritance of a melanocortin-4 receptor mutation in a patient with severe early-onset obesity is due to a dominant-negative effect caused by receptor dimerization
    Heike Biebermann
    Otto Heubner Centrum für Kinderheilkunde und Jugendmedizin, Pädiatrische Endokrinologie, Charite Campus Virchow Klinikum, Humboldt Universitat zu Berlin, Berlin, Germany
    Diabetes 52:2984-8. 2003
    ..The finding of receptor dimerization highlights a more complex hypothalamic signaling network governing the regulation of body weight...
  30. ncbi request reprint Obesity due to proopiomelanocortin deficiency: three new cases and treatment trials with thyroid hormone and ACTH4-10
    Heiko Krude
    Institute of Pediatric Endocrinology, University Children s Hospital, Charite, Humboldt University Berlin, D 13353 Berlin, Germany
    J Clin Endocrinol Metab 88:4633-40. 2003
    ..In the same two patients, further investigation revealed a mildly elevated TSH. However, a 1-yr treatment with thyroid hormone did not result in a significant reduction of body weight...
  31. doi request reprint Analysis of the Wilms' tumor suppressor gene (WT1) in patients 46,XY disorders of sex development
    B Kohler
    Department of Pediatric Endocrinology, University Children s Hospital, Charite, Augustenburger Platz 1, 13353 Berlin, Germany
    J Clin Endocrinol Metab 96:E1131-6. 2011
    ..WT1 mutations have been identified in 46,XY disorders of sex development (DSD) with associated kidney disease and in few isolated forms of 46,XY DSD...
  32. ncbi request reprint Reduced 11beta-hydroxysteroid dehydrogenase type 1 activity in obese boys
    Susanna Wiegand
    Paediatric Endocrinology, Campus Virchow, Charite University Medicine Berlin, 13353, Berlin, Germany
    Eur J Endocrinol 157:319-24. 2007
    ..Altered 11beta-HSD1 may cause tissue-specific Cushing's syndrome with central obesity and impaired glucose homeostasis...
  33. ncbi request reprint Mutations in the human proopiomelanocortin gene
    Heiko Krude
    Pediatric Endocrinology, Otto Heubner Center for Pediatrics, Charite University Hospital, Humboldt University, Berlin, Germany
    Ann N Y Acad Sci 994:233-9. 2003
    ..However, whether partial loss of function mutations in the POMC gene might lead to more circumscribed phenotypes, especially common obesity, remains an open question...
  34. ncbi request reprint Severe congenital hyperthyroidism caused by a germ-line neo mutation in the extracellular portion of the thyrotropin receptor
    A Gruters
    Children s Hospital, Charite Virchow Klinikum, Humboldt Universität zu, Berlin, Germany
    J Clin Endocrinol Metab 83:1431-6. 1998
    ....
  35. doi request reprint Is there a further acceleration in the age at onset of menarche? A cross-sectional study in 1840 school children focusing on age and bodyweight at the onset of menarche
    A M Bau
    Institute for Experimental Pediatric Endocrinology, Charite University Medicine Berlin, Berlin, Germany
    Eur J Endocrinol 160:107-13. 2009
    ..More than 30 years ago Frisch and Revelle proposed a body weight threshold for the onset of menarche. Based on this hypothesis, a further acceleration of age at menarche can be expected in times of childhood obesity...
  36. doi request reprint A new phenotype of nongoitrous and nonautoimmune hyperthyroidism caused by a heterozygous thyrotropin receptor mutation in transmembrane helix 6
    Franziska Winkler
    Institute of Experimental Pediatric Endocrinology, Charite Universitatsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
    J Clin Endocrinol Metab 95:3605-10. 2010
    ..In the past, it was assumed that thyroid hyperplasia is due to constitutive activation of the Gs/adenylyl cyclase signaling pathway; however, the physiological role of the Gq/11 pathway in this context remains unclear...
  37. pmc Essential molecular determinants for thyroid hormone transport and first structural implications for monocarboxylate transporter 8
    Anita Kinne
    Institut für Experimentelle Endokrinologie, Charite Universitatsmedizin Berlin, 13353 Berlin, Germany
    J Biol Chem 285:28054-63. 2010
    ..The MCT8 model allows us to rationalize potential interactions of amino acids including those mutated in patients with Allan-Herndon-Dudley syndrome...
  38. doi request reprint Surface translocation and tri-iodothyronine uptake of mutant MCT8 proteins are cell type-dependent
    Anita Kinne
    Institute for Experimental Endocrinology Institute for Experimental Pediatric Endocrinology, Charite Universitatsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
    J Mol Endocrinol 43:263-71. 2009
    ....
  39. ncbi request reprint The prevalence of anti-thyroid peroxidase antibodies and autoimmune thyroiditis in children and adolescents in an iodine replete area
    M Kabelitz
    University Children s Hospital Charite, Humboldt University Berlin, Augustenburger Platz 1, Germany
    Eur J Endocrinol 148:301-7. 2003
    ..The iodine supply of the population in Berlin has normalized during the last 5 Years. Therefore autoimmune thyroiditis has become the most important differential diagnosis in children and adolescents with goiter...
  40. ncbi request reprint Mutationally induced disulfide bond formation within the third extracellular loop causes melanocortin 4 receptor inactivation in patients with obesity
    Patrick Tarnow
    Otto Heubner Centrum für Kinderheilkunde und Jugendmedizin, Pädiatrische Endokrinologie, Charite Campus Virchow Klinikum, Humboldt Universitat zu Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
    J Biol Chem 278:48666-73. 2003
    ..By demonstrating that a loss of a disulfide bond-participating Cys residue can favor a functionally disastrous disulfide bond, we now add a new mechanism of how Cys residues can be involved in G-protein-coupled receptor malfunction...