Christoph Gruber

Summary

Affiliation: Humboldt University
Country: Germany

Publications

  1. ncbi request reprint Delayed hypersensitivity to tuberculin, total immunoglobulin E, specific sensitization, and atopic manifestation in longitudinally followed early Bacille Calmette-Guérin-vaccinated and nonvaccinated children
    C Gruber
    Children s Hospital, Charite Campus Virchow, Medical Faculty of Humboldt Universität, Berlin, Germany
    Pediatrics 107:E36. 2001
  2. pmc Childhood immunisations and the development of atopic disease
    C Gruber
    Arch Dis Child 90:553-5. 2005
  3. ncbi request reprint The effect of hydrotherapy on the incidence of common cold episodes in children: a randomised clinical trial
    Christoph Gruber
    Department of Paediatric Pneumology and Immunology, Charite Children s Hospital, Humboldt University, Campus Virchow, Augustenburger Platz 1, 13353 Berlin, Germany
    Eur J Pediatr 162:168-76. 2003
  4. ncbi request reprint Transient suppression of atopy in early childhood is associated with high vaccination coverage
    Christoph Gruber
    Department of Pediatric Pneumology and Immunology, Charite Humboldt University, Berlin, Germany
    Pediatrics 111:e282-8. 2003
  5. doi request reprint History of respiratory infections in the first 12 yr among children from a birth cohort
    Christoph Gruber
    Department of Pediatric Pneumology and Immunology, Charite Universitatsmedizin Berlin, Berlin, Germany
    Pediatr Allergy Immunol 19:505-12. 2008
  6. ncbi request reprint Is early BCG vaccination associated with less atopic disease? An epidemiological study in German preschool children with different ethnic backgrounds
    Christoph Gruber
    University Children s Hospital, Charite, Humboldt University, Berlin, Germany
    Pediatr Allergy Immunol 13:177-81. 2002
  7. doi request reprint Reduced occurrence of early atopic dermatitis because of immunoactive prebiotics among low-atopy-risk infants
    Christoph Gruber
    Department of Pediatric Pneumology and Immunology, Charite Universitatsmedizin Berlin, Berlin, Germany
    J Allergy Clin Immunol 126:791-7. 2010
  8. ncbi request reprint Cultural adaptation is associated with atopy and wheezing among children of Turkish origin living in Germany
    C Gruber
    Department of Paediatric Pneumology and Immunology, Charite Humboldt University, Berlin, Germany
    Clin Exp Allergy 32:526-31. 2002
  9. ncbi request reprint Do early childhood immunizations influence the development of atopy and do they cause allergic reactions?
    C Gruber
    Department of Pediatric Pneumology and Immunology, Charite Humboldt University, Berlin, Germany
    Pediatr Allergy Immunol 12:296-311. 2001
  10. ncbi request reprint Filaggrin loss-of-function mutations predispose to phenotypes involved in the atopic march
    Ingo Marenholz
    Pediatric Pneumology and Immunology, Charite University Medicine, Berlin, Germany
    J Allergy Clin Immunol 118:866-71. 2006

Collaborators

Detail Information

Publications22

  1. ncbi request reprint Delayed hypersensitivity to tuberculin, total immunoglobulin E, specific sensitization, and atopic manifestation in longitudinally followed early Bacille Calmette-Guérin-vaccinated and nonvaccinated children
    C Gruber
    Children s Hospital, Charite Campus Virchow, Medical Faculty of Humboldt Universität, Berlin, Germany
    Pediatrics 107:E36. 2001
    ..Bacille Calmette-Guérin (BCG) is a strong T helper 1 incentive and, thus, may contribute to a decreased risk of T helper 2-dependent atopic disease...
  2. pmc Childhood immunisations and the development of atopic disease
    C Gruber
    Arch Dis Child 90:553-5. 2005
  3. ncbi request reprint The effect of hydrotherapy on the incidence of common cold episodes in children: a randomised clinical trial
    Christoph Gruber
    Department of Paediatric Pneumology and Immunology, Charite Children s Hospital, Humboldt University, Campus Virchow, Augustenburger Platz 1, 13353 Berlin, Germany
    Eur J Pediatr 162:168-76. 2003
    ..In the study period, there were no significant differences in the incidence of colds (control vs. experimental group, mean +/- SD, 4.8+/-3.5 vs. 4.1+/-3.3 episodes) or the average duration of episodes (7.7+/-3.5 vs. 7.6+/-3.8 days)...
  4. ncbi request reprint Transient suppression of atopy in early childhood is associated with high vaccination coverage
    Christoph Gruber
    Department of Pediatric Pneumology and Immunology, Charite Humboldt University, Berlin, Germany
    Pediatrics 111:e282-8. 2003
    ..To analyze prevalences of allergic sensitization and atopic disease in relation to vaccination coverage...
  5. doi request reprint History of respiratory infections in the first 12 yr among children from a birth cohort
    Christoph Gruber
    Department of Pediatric Pneumology and Immunology, Charite Universitatsmedizin Berlin, Berlin, Germany
    Pediatr Allergy Immunol 19:505-12. 2008
    ..Episodes within these reference values per se should not cause unwarranted concern or intervention because of suspected immunodeficiency...
  6. ncbi request reprint Is early BCG vaccination associated with less atopic disease? An epidemiological study in German preschool children with different ethnic backgrounds
    Christoph Gruber
    University Children s Hospital, Charite, Humboldt University, Berlin, Germany
    Pediatr Allergy Immunol 13:177-81. 2002
    ..This study demonstrated a weak protective effect of BCG vaccination against asthma but a much stronger protective effect of non-German ethnicity against atopic manifestations among preschool children from Germany...
  7. doi request reprint Reduced occurrence of early atopic dermatitis because of immunoactive prebiotics among low-atopy-risk infants
    Christoph Gruber
    Department of Pediatric Pneumology and Immunology, Charite Universitatsmedizin Berlin, Berlin, Germany
    J Allergy Clin Immunol 126:791-7. 2010
    ..Most infants developing atopic dermatitis have a low risk for atopy. Primary prevention of atopic dermatitis is difficult...
  8. ncbi request reprint Cultural adaptation is associated with atopy and wheezing among children of Turkish origin living in Germany
    C Gruber
    Department of Paediatric Pneumology and Immunology, Charite Humboldt University, Berlin, Germany
    Clin Exp Allergy 32:526-31. 2002
    ..Turkish children have been found to suffer less from atopic diseases than their German peers. The underlying causes are unknown...
  9. ncbi request reprint Do early childhood immunizations influence the development of atopy and do they cause allergic reactions?
    C Gruber
    Department of Pediatric Pneumology and Immunology, Charite Humboldt University, Berlin, Germany
    Pediatr Allergy Immunol 12:296-311. 2001
    ..Therefore, childhood vaccination remains an essential part of child health programs and should not be withheld, even from children predisposed for allergy...
  10. ncbi request reprint Filaggrin loss-of-function mutations predispose to phenotypes involved in the atopic march
    Ingo Marenholz
    Pediatric Pneumology and Immunology, Charite University Medicine, Berlin, Germany
    J Allergy Clin Immunol 118:866-71. 2006
    ..Recently, 2 loss-of-function mutations in the gene encoding the epidermal barrier protein filaggrin were reported to be predisposing factors for eczema and concomitant asthma, suggesting a possible role in disease transition...
  11. ncbi request reprint The natural course of atopic dermatitis from birth to age 7 years and the association with asthma
    Sabina Illi
    Department of Pediatric Pneumology and Immunology, Charite, Dr von Haunersches Kinderspital, Lindwurmastrasse 4, 80337 Munich, Germany
    J Allergy Clin Immunol 113:925-31. 2004
    ..Atopic dermatitis (AD) is considered to be one of the first manifestations in the atopic march. However, few prospective studies on AD and its association with childhood asthma exist...
  12. ncbi request reprint Perennial allergen sensitisation early in life and chronic asthma in children: a birth cohort study
    Sabina Illi
    Department of Pediatric Pneumology and Immunology, Charite Universitatsmedizin Berlin, Germany
    Lancet 368:763-70. 2006
    ..Unknown factors between birth and school age determine the progressive loss of pulmonary function in children with persistent asthma. We investigated the role of allergic sensitisation and allergen exposure early in life...
  13. ncbi request reprint The development of childhood asthma: lessons from the German Multicentre Allergy Study (MAS)
    Susanne Lau
    University Children s Hospital, Department of Pneumology and Immunology Berlin, Charite Campus Virchow, Augustenburger Platz 1, 13353 Berlin, Germany
    Paediatr Respir Rev 3:265-72. 2002
    ....
  14. ncbi request reprint Messages from the German Multicentre Allergy Study
    Renate Nickel
    Department for Pediatric Pneumology and Immunology, Charite, Berlin, Germany
    Pediatr Allergy Immunol 13:7-10. 2002
    ..Furthermore, candidate gene studies of atopic dermatitis and increased total serum IgE levels on chromosomes 5q, 12q and 17q in MAS-children and their parents are outlined...
  15. ncbi request reprint How should a birth cohort study be organised? Experience from the German MAS cohort study
    Renate Nickel
    University Children s Hospital, Department of Pneumology and Immunology, Charite Campus Virchow, Augustenburger Platz 1, 13353 Berlin, Germany
    Paediatr Respir Rev 3:169-76. 2002
    ....
  16. ncbi request reprint MBL2 variants in relation to common childhood infections and atopy-related phenotypes in a large German birth cohort
    Sebastian Müller
    Department of Pediatric Pneumology and Immunology, Charité Universitäts medizin, Berlin, Germany
    Pediatr Allergy Immunol 18:665-70. 2007
    ..Our data suggest that MBL deficiency does not represent a pre-disposing factor for respiratory infections or atopic disorders in infants and children...
  17. ncbi request reprint A common haplotype of the IL-31 gene influencing gene expression is associated with nonatopic eczema
    Florian Schulz
    Pediatric Pneumology and Immunology, Charite, Berlin, Germany
    J Allergy Clin Immunol 120:1097-102. 2007
    ..IL-31 is a novel cytokine that, when overexpressed in transgenic mice, induces severe itching dermatitis resembling human eczema...
  18. ncbi request reprint A practical approach to immunization in atopic children
    Christoph Gruber
    Department of Pediatric Pneumology and Immunology, Charite Humboldt University, Berlin, Germany
    Allergy 57:472-9. 2002
  19. doi request reprint Serum retinoic acid and atopy among children of different ethnic origin living in Germany
    Christoph Gruber
    Department of Pediatric Pneumology and Immunology, Charite Universitatsmedizin Berlin, Berlin, Germany
    J Pediatr Gastroenterol Nutr 54:558-60. 2012
    ..They did not differ significantly between atopic and nonatopic individuals. Serum levels of ATRA are related to those of provitamin A carotenoids but are not directly related to atopy in the present study...
  20. ncbi request reprint Does unconventional medicine work through conventional modes of action?
    Bodo Niggemann
    Department of Pediatric Pneumology and Immunology, University Children s Hospital Charite, Humboldt University, Berlin, Germany
    J Allergy Clin Immunol 118:569-73. 2006
    ..This might demystify the aura of some of the complementary and alternative approaches and might help to bring both conventional and unconventional approaches together on a scientific basis...
  21. ncbi request reprint Unconventional and conventional medicine: who should learn from whom?
    Bodo Niggemann
    Department of Pediatric Pneumology and Immunology, University Children s Hospital Charite, Humboldt University, Berlin, Germany
    Pediatr Allergy Immunol 14:149-55. 2003
    ..Chances and risks of unconventional methods are discussed. However, only by considering controlled studies can conventional and unconventional diagnostic and therapeutic methods be advocated on the basis of evidence rather than ideology...
  22. pmc Variants in a novel epidermal collagen gene (COL29A1) are associated with atopic dermatitis
    Cilla Söderhäll
    Department of Pediatric Pneumology and Immunology, Charite Universitatsmedizin Berlin, Germany
    PLoS Biol 5:e242. 2007
    ..Lack of COL29A1 expression in the outer epidermis of AD patients points to a role of collagen XXIX in epidermal integrity and function, the breakdown of which is a clinical hallmark of AD...