Detlev Ganten

Summary

Affiliation: Humboldt University
Country: Germany

Publications

  1. ncbi Hearts of this ILK rely on TNNI3K, a MAPKKK that regulated TNNI3
    Friedrich C Luft
    Humboldt University of Berlin, Berlin Buch, Germany
    J Mol Med (Berl) 81:279-80. 2003
  2. ncbi Harbingers of hypertrophy and heart failure
    F C Luft
    Franz Vollhard Clinic, HELIOS Klinikum Berlin, Medical Faculty of the Charite, Humboldt University of Berlin, Wiltbergstrasse 50, 13125 Berlin Buch, Germany
    J Mol Med (Berl) 82:635-7. 2004
  3. ncbi The serum- and glucocorticoid-induced kinase in DOCA-salt hypertension
    Friedrich C Luft
    Franz Volhard Clinic, HELIOS Kliniken Berlin, Medical Faculty of the Charite, Humboldt University, Wiltbergstrasse 50, 13125, Berlin Buch, Germany
    J Mol Med (Berl) 84:709-11. 2006
  4. ncbi Tissue renin-angiotensin system and end-organ damage
    Friedrich C Luft
    Franz Volhard Klinik, Humboldt University of Berlin, Wiltbergstrasse 50, 13125 Berlin Buch, Germany
    J Mol Med (Berl) 80:325-6. 2002
  5. ncbi Present status of genetic mechanisms in hypertension
    Friedrich C Luft
    Franz Volhard Clinic and Max Delbrück Center for Molecular Medicine, Wiltberg Strasse 50, 13125 Berlin, Germany
    Med Clin North Am 88:1-18, vii. 2004
  6. ncbi Titrating angiotensinogen in salt sensitive hypertension
    Friedrich C Luft
    Franz Volhard Clinic, HELIOS Kliniken Berlin Medical Faculty of the Charité, Humboldt University, Wiltbergstrasse 50, 13125, Berlin Buch, Germany
    J Mol Med (Berl) 85:313-6. 2007
  7. ncbi Cardiopulmonary auscultation: duo for strings--Opus 99
    A Woywodt
    Franz Volhard Clinic, Berlin, Germany
    Arch Intern Med 159:2477-9. 1999
  8. ncbi Farnesol blocks the L-type Ca2+ channel by targeting the alpha 1C subunit
    U C Luft
    Franz Volhard Clinic and Max Delbrück Center for Molecular Medicine, Virchow Klinikum Charite, Humboldt University of Berlin, Berlin, Germany
    Arterioscler Thromb Vasc Biol 19:959-66. 1999
  9. ncbi Molecular genetics of human hypertension
    F C Luft
    Franz Volhard Clinic and Max Delbrück Center for Molecular Medicine, Medizinische Fakulät der Charite, Campus Buch, Humboldt University of Berlin, Germany
    J Hypertens 16:1871-8. 1998
  10. ncbi Doxorubicin toxicity in the Iron Age
    Friedrich C Luft
    Franz Volhard Clinic, HELIOS Kliniken Berlin, Medical Faculty of the Charite, Humboldt University, Wiltbergstrasse 50, 13125 Berlin Buch, Germany
    J Mol Med (Berl) 84:529-31. 2006

Collaborators

Detail Information

Publications143 found, 100 shown here

  1. ncbi Hearts of this ILK rely on TNNI3K, a MAPKKK that regulated TNNI3
    Friedrich C Luft
    Humboldt University of Berlin, Berlin Buch, Germany
    J Mol Med (Berl) 81:279-80. 2003
  2. ncbi Harbingers of hypertrophy and heart failure
    F C Luft
    Franz Vollhard Clinic, HELIOS Klinikum Berlin, Medical Faculty of the Charite, Humboldt University of Berlin, Wiltbergstrasse 50, 13125 Berlin Buch, Germany
    J Mol Med (Berl) 82:635-7. 2004
  3. ncbi The serum- and glucocorticoid-induced kinase in DOCA-salt hypertension
    Friedrich C Luft
    Franz Volhard Clinic, HELIOS Kliniken Berlin, Medical Faculty of the Charite, Humboldt University, Wiltbergstrasse 50, 13125, Berlin Buch, Germany
    J Mol Med (Berl) 84:709-11. 2006
  4. ncbi Tissue renin-angiotensin system and end-organ damage
    Friedrich C Luft
    Franz Volhard Klinik, Humboldt University of Berlin, Wiltbergstrasse 50, 13125 Berlin Buch, Germany
    J Mol Med (Berl) 80:325-6. 2002
  5. ncbi Present status of genetic mechanisms in hypertension
    Friedrich C Luft
    Franz Volhard Clinic and Max Delbrück Center for Molecular Medicine, Wiltberg Strasse 50, 13125 Berlin, Germany
    Med Clin North Am 88:1-18, vii. 2004
    ..Association studies, linkage analyses, single nucleotide polymorphism analyses, synteny in animal models, and gene expression studies are the current tools and steady progress is being made...
  6. ncbi Titrating angiotensinogen in salt sensitive hypertension
    Friedrich C Luft
    Franz Volhard Clinic, HELIOS Kliniken Berlin Medical Faculty of the Charité, Humboldt University, Wiltbergstrasse 50, 13125, Berlin Buch, Germany
    J Mol Med (Berl) 85:313-6. 2007
  7. ncbi Cardiopulmonary auscultation: duo for strings--Opus 99
    A Woywodt
    Franz Volhard Clinic, Berlin, Germany
    Arch Intern Med 159:2477-9. 1999
    ..Cardiopulmonary auscultation should receive more emphasis in the medical school curriculum and clinical training...
  8. ncbi Farnesol blocks the L-type Ca2+ channel by targeting the alpha 1C subunit
    U C Luft
    Franz Volhard Clinic and Max Delbrück Center for Molecular Medicine, Virchow Klinikum Charite, Humboldt University of Berlin, Berlin, Germany
    Arterioscler Thromb Vasc Biol 19:959-66. 1999
    ..Finally, farnesol has a blood pressure-lowering action that may be relevant in vivo...
  9. ncbi Molecular genetics of human hypertension
    F C Luft
    Franz Volhard Clinic and Max Delbrück Center for Molecular Medicine, Medizinische Fakulät der Charite, Campus Buch, Humboldt University of Berlin, Germany
    J Hypertens 16:1871-8. 1998
    ..Finally, rethinking the phenotype 'hypertension' and its intermediates must also receive priority...
  10. ncbi Doxorubicin toxicity in the Iron Age
    Friedrich C Luft
    Franz Volhard Clinic, HELIOS Kliniken Berlin, Medical Faculty of the Charite, Humboldt University, Wiltbergstrasse 50, 13125 Berlin Buch, Germany
    J Mol Med (Berl) 84:529-31. 2006
  11. pmc Management of high-risk patients with hypertension and left ventricular hypertrophy in Germany: differences between cardiac specialists in the inpatient and outpatient setting
    Heinz Völler
    Klinik am See, Seestrasse 84, D 15562 Rüdersdorf bei Berlin, Germany
    BMC Public Health 6:256. 2006
    ..We aimed to investigate differences in characteristics and health care management of such patients treated as inpatients or outpatients by cardiac specialists...
  12. pmc Posttransplantation malignancy in a patient presenting with weight loss and changed bowel habits: a case report
    Roland Schmitt
    Medical Faculty of the Charite, Franz Volhard Clinic, HELIOS Klinikum Berlin, Germany
    BMC Nephrol 7:9. 2006
    ..Advancements in immunosuppressive therapy have significantly improved patient and graft survival following renal transplantation. This is paralleled by an increasing occurrence of posttransplantation malignancy...
  13. pmc Angiotensin II induced inflammation in the kidney and in the heart of double transgenic rats
    Juergen Theuer
    Franz Volhard Clinic, Charite and Max Delbrück Center for Molecular Medicine, Berlin, Humboldt University of Berlin, Germany
    BMC Cardiovasc Disord 2:3. 2002
    ..Leukocyte infiltration in the vascular wall accompanies PAI-1, MCP-1, iNOS and Tissue Factor expression. Furthermore we show evidence that Ang II causes the upregulation of NF-kB in our model...
  14. ncbi Liver stage antigen and malaria
    Friedrich C Luft
    Franz Volhard Clinic, HELIOS Kliniken Berlin, Medical Faculty of the Charite, Humboldt University, Wiltbergstrasse 50, 13125, Berlin Buch, Germany
    J Mol Med (Berl) 82:555-7. 2004
  15. ncbi The disease that never was
    Friedrich C Luft
    Franz Volhard Clinic, HELIOS Kliniken Berlin, Medical Faculty of the Charite, Humboldt University, Wiltbergstrasse 50, 13125, Berlin Buch, Germany
    J Mol Med (Berl) 82:723-4. 2004
  16. ncbi Matrix metalloproteinases and their regulators are cardiovascular therapeutic targets
    Friedrich C Luft
    Franz Volhard Clinic, HELIOS Kliniken Berlin, Medical Faculty of the Charite, Humboldt University, Wiltbergstrasse 50, 13125, Berlin Buch, Germany
    J Mol Med (Berl) 82:781-3. 2004
  17. ncbi Cardiac reconstruction in the Jurassic Period
    Friedrich C Luft
    Franz Volhard Clinic, HELIOS Kliniken Berlin, Medical Faculty of the Charite, Humboldt University, Wiltbergstrasse 50, 13125 Berlin Buch, Germany
    J Mol Med (Berl) 82:485-7. 2004
  18. ncbi Oscar M. Helmer, you had it right
    Friedrich C Luft
    Franz Volhard Clinic, HELIOS Kliniken Berlin, Medical Faculty of the Charite, Humboldt University, Wiltbergstrasse 50, 13125 Berlin Buch, Germany
    J Mol Med (Berl) 83:85-7. 2005
  19. ncbi Hypertensive nephrosclerosis: update
    Friedrich C Luft
    Franz Volhard Clinic, Medical Faculty of the Charite, HELIOS Klinikum, Berlin, Germany
    Curr Opin Nephrol Hypertens 13:147-54. 2004
    ..Important human and animal studies have addressed mechanistic issues regarding renal disease progression. These advances warrant detailed discussion...
  20. ncbi After chylomicron remnants, what is left?
    Friedrich C Luft
    Franz Volhard Clinic, HELIOS Kliniken Berlin, Medical Faculty of the Charite, Humboldt University, Wiltbergstrasse 50, 13125, Berlin Buch, Germany
    J Mol Med (Berl) 82:411-3. 2004
  21. ncbi Geneticism of essential hypertension
    Friedrich C Luft
    Medical Faculty of the Charite, Franz Volhard Clinic HELIOS Klinikum Berlin and Max Delbrück Center for Molecular Medicine, Berlin, Germany
    Hypertension 43:1155-9. 2004
  22. ncbi Mendelian hypertension with brachydactyly as a molecular genetic lesson in regulatory physiology
    Friedrich C Luft
    The Clinic Research Center of the franz Volhard Clinic, University of Berlin, 13125 Berlin, Germany
    Am J Physiol Regul Integr Comp Physiol 285:R709-14. 2003
    ..Our study underscores the importance of regulatory physiology to the understanding of a complex genetic syndrome...
  23. ncbi What the lions say
    Friedrich C Luft
    Franz Volhard Klinik, Humboldt University of Berlin, Germany
    J Mol Med (Berl) 81:453-4. 2003
  24. ncbi Thinking about zinc
    Friedrich C Luft
    Franz Volhard Klinik, Humboldt University of Berlin, Wiltbergstrasse 50, 13125 Berlin Buch, Germany
    J Mol Med (Berl) 81:597-9. 2003
  25. ncbi A very phoxy business
    Friedrich C Luft
    Franz Volhard Clinic, HELIOS Kliniken Berlin, Medical Faculty of the Charite, Humboldt University, Wiltbergstrasse 50, 13125 Berlin Buch, Germany
    J Mol Med (Berl) 82:1-3. 2004
  26. ncbi What clinicians should know about SV40 large T antigen and nucleocytoplasmic transport
    Friedrich C Luft
    Franz Volhard Clinic, HELIOS Klinikum Berlin, Medical Faculty of the Charite, Humboldt University, 13125 Berlin Buch, Germany
    J Mol Med (Berl) 81:675-7. 2003
  27. ncbi Would a vitamin help, doctor?
    Friedrich C Luft
    Franz Volhard Clinic, HELIOS Kliniken Berlin, Medical Faculty of the Charite, Humboldt University, Wiltbergstrasse 50, 13125, Berlin Buch, Germany
    J Mol Med (Berl) 82:71-3. 2004
  28. ncbi Sudden cardiac death is a very serious matter
    Friedrich C Luft
    Franz Volhard Clinic, HELIOS Kliniken Berlin, Medical Faculty of the Charite, Humboldt University, Wiltbergstrasse 50, 13125 Berlin Buch, Germany
    J Mol Med (Berl) 82:153-5. 2004
  29. pmc Sticky wickets in lower nephron nephrosis
    Friedrich C Luft
    Medical Faculty of the Charite, Franz Volhard Clinic, Helios Klinikum Berlin and Max Delbrück Center for Molecular Medicine, Germany
    J Physiol 557:703. 2004
  30. ncbi Phosphate's fate made easier
    Friedrich C Luft
    Franz Volhard Clinic, HELIOS Kliniken Berlin, Medical Faculty of the Charite, Humboldt University, Wiltbergstrasse 50, 13125 Berlin Buch, Germany
    J Mol Med (Berl) 83:1-2. 2005
  31. ncbi Abrupt hypokalemia with paralysis from a clinician's perspective
    Friedrich C Luft
    Franz Volhard Clinic, HELIOS Kliniken Berlin, Medical Faculty of the Charite, Humboldt University, Wiltbergstrasse 50, 13125, Berlin Buch, Germany
    J Mol Med (Berl) 83:167-9. 2005
  32. ncbi Somatic DNA oxidative damage and coronary disease
    Friedrich C Luft
    Franz Volhard Clinic, HELIOS Kliniken Berlin, Medical Faculty of the Charite, Humboldt University, Wiltbergstrasse 50, 13125 Berlin Buch, Germany
    J Mol Med (Berl) 83:241-3. 2005
  33. ncbi Genetic mutation screening for the low-density lipoprotein receptor
    Friedrich C Luft
    Franz Volhard Clinic, HELIOS Kliniken Berlin, Medical Faculty of the Charite, Humboldt University, Wiltbergstrasse 50, 13125 Berlin Buch, Germany
    J Mol Med (Berl) 84:183-4. 2006
  34. ncbi The cathepsins contribute to life and death in the placenta
    Friedrich C Luft
    Franz Volhard Clinic, HELIOS Kliniken Berlin, Medical Faculty of the Charite, Humboldt University, Berlin Buch, Germany
    J Mol Med (Berl) 84:259-61. 2006
  35. ncbi Suicidal erythrocyte death occurs in the hemolytic uremic syndrome
    Friedrich C Luft
    Franz Volhard Clinic, HELIOS Kliniken Berlin, Medical Faculty of the Charite, Humboldt University, Wiltbergstrasse 50, 13125 Berlin Buch, Germany
    J Mol Med (Berl) 84:347-8. 2006
  36. ncbi The jolly gentle giant titin explains Frank and Starling
    Friedrich C Luft
    Franz Volhard Clinic, HELIOS Kliniken Berlin, Medical Faculty of the Charite, Humboldt University, Wiltbergstrasse 50, 13125, Berlin Buch, Germany
    J Mol Med (Berl) 84:443-5. 2006
  37. ncbi SGK1 survival through various lives may save us all
    Friedrich C Luft
    Franz Volhard Clinic, HELIOS Kliniken Berlin, Medical Faculty of the Charite, Humboldt University, Wiltbergstrasse 50, 13125, Berlin Buch, Germany
    J Mol Med (Berl) 85:657-9. 2007
  38. ncbi Are human CETP mutations and CETP-inhibiting drugs a good or a bad deal?
    Friedrich C Luft
    Franz Volhard Clinic, HELIOS Kliniken Berlin, Medical Faculty of the Charite, Humboldt University, Wiltbergstrasse 50, 13125 Berlin Buch, Germany
    J Mol Med (Berl) 84:625-7. 2006
  39. ncbi On Fever, famine, and war--but mostly fever
    Friedrich C Luft
    Franz Volhard Clinic, HELIOS Kliniken Berlin Medical Faculty of the Charité, Humboldt University, Wiltbergstrasse 50, 13125, Berlin Buch, Germany
    J Mol Med (Berl) 84:799-801. 2006
  40. ncbi A high mobility group box-containing transcription factor leads to diabetes risk
    Friedrich C Luft
    Franz Volhard Clinic, HELIOS Kliniken Berlin, Medical Faculty of the Charite, Humboldt University, Berlin Buch, Germany
    J Mol Med (Berl) 84:985-7. 2006
  41. ncbi A fat attack occurred in fat city
    Friedrich C Luft
    Franz Volhard Clinic, HELIOS Kliniken Berlin, Medical Faculty of the Charite, Humboldt University, 13125 Berlin Buch, Germany
    J Mol Med (Berl) 84:1-3. 2006
  42. ncbi Light shed on the common skin scourge, psoriasis
    Friedrich C Luft
    Franz Volhard Clinic, HELIOS Kliniken Berlin, Medical Faculty of the Charite, Humboldt University, Wiltbergstrasse 50, 13125, Berlin Buch, Germany
    J Mol Med (Berl) 83:933-4. 2005
  43. ncbi Is imprinting in printing or in press?
    Friedrich C Luft
    Franz Volhard Clinic, HELIOS Kliniken Berlin, Medical Faculty of the Charite, Humboldt University, Wiltbergstrasse 50, 13125 Berlin Buch, Germany
    J Mol Med (Berl) 83:321-3. 2005
  44. ncbi More reactive and less reactive C-reactive protein
    Friedrich C Luft
    Franz Volhard Clinic, HELIOS Kliniken Berlin, Medical Faculty of the Charite, Humboldt University, Wiltbergstrasse 50, 13125 Berlin Buch, Germany
    J Mol Med (Berl) 83:411-2. 2005
  45. pmc Mendelian forms of human hypertension and mechanisms of disease
    Friedrich C Luft
    Franz Volhard Clinic HELIOS Klinikum Berlin and Max Delbrück Center for Molecular Medicine, Medical Faculty of the Charite, Humboldt University of Berlin, Germany
    Clin Med Res 1:291-300. 2003
    ..Finally, at least 5 different genes have been described that when mutated can cause pheochromocytoma. Thus, the elucidation of Mendelian blood pressure-regulatory disorders has been a resounding success...
  46. ncbi Pancaspase and cardiac function after infarction
    Friedrich C Luft
    Franz Volhard Clinic, HELIOS Kliniken Berlin, Medical Faculty of the Charite, Humboldt University, Wiltbergstrasse 50, 13125 Berlin Buch, Germany
    J Mol Med (Berl) 83:497-9. 2005
  47. ncbi NOD takes its toll but stays in the CARDs in Crohn's disease
    Friedrich C Luft
    Franz Volhard Clinic, HELIOS Kliniken Berlin, Medical Faculty of the Charite, Humboldt University, Wiltbergstrasse 50, 13125, Berlin Buch, Germany
    J Mol Med (Berl) 83:577-8. 2005
  48. ncbi Rocking around the clock, while time is relative
    Friedrich C Luft
    Franz Volhard Clinic, HELIOS Kliniken Berlin, Medical Faculty of the Charite, Humboldt University, Wiltbergstrasse 50, 13125, Berlin Buch, Germany
    J Mol Med (Berl) 83:655-6. 2005
  49. ncbi How complex is Complex I?
    Friedrich C Luft
    Franz Volhard Clinic, HELIOS Kliniken Berlin, Medical Faculty of the Charite, Humboldt University, Germany
    J Mol Med (Berl) 83:749-51. 2005
  50. ncbi Preeclampsia, Eve, and Adam join forces
    Friedrich C Luft
    Franz Volhard Clinic, HELIOS Kliniken Berlin, Medical Faculty of the Charite, Humboldt University, Wiltbergstrasse 50, 13125, Berlin Buch, Germany
    J Mol Med (Berl) 83:839-41. 2005
  51. ncbi Better days are coming for Riley-Day patients
    F C Luft
    Franz Volhard Clinic, Helios, Kliniken Berlin Medical Faculty of the Charité, Humboldt University, Wiltbergstrasse 50, 13125 Berlin Buch, Germany
    J Mol Med (Berl) 85:99-101. 2007
  52. ncbi Nectar from adipocytes
    Friedrich C Luft
    Franz Volhard Klinik, Humboldt University of Berlin, Berlin Buch, Germany
    J Mol Med (Berl) 81:389-91. 2003
  53. ncbi Angiotensin, inflammation, hypertension, and cardiovascular disease
    F C Luft
    Franz Volhard Clinic and Max Delbrück Center for Molecular Medicine, Wiltberg Strasse 50, 13125 Berlin, Germany
    Curr Hypertens Rep 3:61-7. 2001
    ..It stimulates the proliferation of lymphocytes and contributes to their activation via calcineurin-related pathways. Knowledge of these mechanisms may provide additional therapeutic avenues...
  54. ncbi Glucocorticoid receptor function and clinical medicine
    Friedrich C Luft
    Franz Volhard Klinik, Humboldt University of Berlin, Wiltbergstrasse 50, 13125 Berlin Buch, Germany
    J Mol Med (Berl) 80:267-9. 2002
  55. ncbi Proinflammatory effects of angiotensin II and endothelin: targets for progression of cardiovascular and renal diseases
    Friedrich C Luft
    HELIOS Klinikum Berlin Franz Volhard Clinic and Max Delbrück Center for Molecular Medicine, Medical Faculty of the Charite, Humboldt University of Berlin, Germany
    Curr Opin Nephrol Hypertens 11:59-66. 2002
    ..The recent elucidation of the endothelin converting enzyme's physical structure should facilitate the development of still more novel compounds to inhibit endothelin-1 generation...
  56. ncbi Twin studies in the analysis of minor physiological differences between individuals
    Andreas Busjahn
    Franz Volhard Clinic, HELIOS Klinikum Berlin, Medical Faculty of the Charite, Humboldt University of Berlin HealthTwiSt GmbH, Berlin
    Cell Physiol Biochem 13:51-8. 2003
    ..These data, coupled with our earlier observations linking the insulin-like growth factor-1 gene locus to blood pressure lead us to conclude that the SGK1 gene is relevant to blood pressure regulation and probably to hypertension in man...
  57. ncbi Son of a mother against decapentaplegic
    F C Luft
    Franz Volhard Klinik, Humboldt University of Berlin, Wiltbergstrasse 50, 13125 Berlin Buch, Germany
    J Mol Med (Berl) 81:1-3. 2003
  58. ncbi Heme oxygenase-1 and mice in red, white, and blue
    Friedrich C Luft
    Franz Volhard Klinik, Humboldt University of Berlin, Wiltbergstrasse 50, 13125 Berlin Buch, Germany
    J Mol Med (Berl) 80:615-7. 2002
  59. ncbi Molecular genetics of human hypertension
    F C Luft
    Franz Volhard Clinic, Medical Faculty of the Charite, Humboldt University of Berlin, Germany
    Curr Opin Nephrol Hypertens 9:259-66. 2000
    ....
  60. ncbi Familial glucocorticoid deficiency syndromes
    Frederich C Luft
    Franz Volhard Klinik, Huboldt University of Berlin, Germany
    J Mol Med (Berl) 80:385-6. 2002
  61. ncbi Salt and hypertension at the close of the millenium
    F C Luft
    Franz Volhard Clinic, Max Delbruck Center for Molecular Medicine, Medizinsche Fakultät der Charité, Humboldt University of Berlin, Federal Republic of Germany
    Wien Klin Wochenschr 110:459-66. 1998
    ..In terms of efficacy, salt restriction has not been shown superior to weight loss or a "vegetable" diet. Nonpharmacological approaches in hypertensive patients should be based on a comprehensive approach...
  62. ncbi Gentamicin as gene therapy
    Friedrich C Luft
    Franz Volhard Klinik, Humboldt University of Berlin, Wiltbergstrasse 50, 13125 Berlin Buch, Germany
    J Mol Med (Berl) 80:543-4. 2002
  63. ncbi Renal disease as a risk factor for cardiovascular disease
    F C Luft
    Carité Campus Buch, Fanz Volhard Clinic, Berlin, Germany
    Basic Res Cardiol 95:I72-6. 2000
    ..Prophylactic measures known to be effective in reducing the risk from cardiovascular disease are grossly underused. Unfortunately, they are less effective in patients with renal disease, and new strategies are needed...
  64. ncbi Endothelin, nephropathy, and blood pressure
    Friedrich C Luft
    Franz Volhard Klinik, Humboldt University of Berlin, Wiltbergstrasse 50, 13125 Berlin Buch, Germany
    J Mol Med (Berl) 80:69-70. 2002
  65. ncbi Transducing proteins to manipulate intracellular targets
    Friedrich C Luft
    Franz Volhard Klinik, Humboldt University of Berlin, Wiltbergstrasse 50, 13125, Berlin Buch, Germany
    J Mol Med (Berl) 81:521-3. 2003
  66. ncbi Molecular genetics of salt-sensitivity and hypertension
    F C Luft
    Franz Volhard Clinic and Max Delbrück Center for Molecular Medicine, Medical Faculty of the Charite, Campus Buch, Humboldt University of Berlin, Germany
    Drug Metab Dispos 29:500-4. 2001
    ..New approaches are necessary to elucidate salt-sensitive hypertension. The analysis of multiple genes simultaneously in terms of a metabolic control analysis may provide a more promising approach...
  67. ncbi Freely associating with chemokine receptor 2 polymorphisms and atherosclerosis
    F C Luft
    Humboldt University of Berlin, Germany
    J Mol Med (Berl) 81:333-5. 2003
  68. ncbi Workshop: mechanisms and cardiovascular damage in hypertension
    F C Luft
    Franz Volhard Clinic and Max Delbrück Center for Molecular Medicine, Medical Faculty of the Charite, Humboldt University of Berlin, Germany
    Hypertension 37:594-8. 2001
    ..Anti-inflammatory interventions may have therapeutic utility...
  69. ncbi Haplotypes, "hyplotypes," and complex genetic disease
    Friedrich C Luft
    Franz Volhard Klinik, Humboldt University of Berlin, Wiltbergstrasse 50, 13125 Berlin Buch, Germany
    J Mol Med (Berl) 81:215-7. 2003
  70. pmc Baa, Baa, black sheep, are your kidneys full?
    Friedrich C Luft
    Franz Volhard Clinic, HELIOS Klinikum, Medical Faculty of the Charite, Humboldt University of Berlin, Wiltberg Strasse 50, 13125 Berlin, Germany
    J Physiol 549:665. 2003
  71. ncbi Estrogen and atherosclerosis
    Friedrich C Luft
    Franz Volhard Klinik, Humboldt University of Berlin, Wiltbergstrasse 50, 13125 Berlin Buch, Germany
    J Mol Med (Berl) 80:133-4. 2002
  72. ncbi Twins in cardiovascular genetic research
    F C Luft
    Franz Volhard Clinic at the Max Delbrück Center for Molecular Medicine, Medical Faculty of the Charite, Humboldt University of Berlin, Germany
    Hypertension 37:350-6. 2001
    ..The use of single-nucleotide polymorphisms then allows for novel association approaches within the cohort. Twin studies will continue to gain in importance and utility, particularly in elucidating normal human genetic diversity...
  73. ncbi PPARgamma and insulin sensitivity: too much and too little of a good thing
    Friedrich C Luft
    Franz Volhard Klinik, Humboldt University of Berlin, Wiltbergstrasse 50, 13125 Berlin Buch, Germany
    J Mol Med (Berl) 80:1-2. 2002
  74. ncbi Hypertension as a complex genetic trait
    Friedrich C Luft
    Franz Volhard Clinic and Max Delbrück Center for Molecular Medicine, HELIOS Klinikum, Medical Faculty of the Charite, Humboldt University of Berlin, Germany
    Semin Nephrol 22:115-26. 2002
    ..Single nucleotide polymorphisms (SNPs) permit linkage dysequilibrium mapping, which may enable cloning new genes. Thus far, very few new genes have been cloned for any complex genetic disease. The task is daunting but not impossible...
  75. ncbi The tetrapeptide N-acetyl-seryl-aspartyl-lysl-proline and angiotensin-converting enzyme
    Friedrich C Luft
    Franz Volhard Klinik, Humboldt University of Berlin, Berlin Buch, Germany
    J Mol Med (Berl) 80:461-2. 2002
  76. ncbi Vascular endothelial cell-specific NF-kappaB suppression attenuates hypertension-induced renal damage
    Norbert Henke
    Medical Faculty of the Charite, Franz Volhard Clinic, HELIOS Klinikum Berlin, Germany
    Circ Res 101:268-76. 2007
    ..We conclude that in vivo NF-kappaB suppression in endothelial cells stops a signaling cascade leading to reduced hypertension-induced renal damage despite high blood pressure...
  77. pmc Immunosuppressive treatment protects against angiotensin II-induced renal damage
    Dominik N Muller
    HELIOS Klinikum Berlin, Franz Volhard Clinic and Medical Faculty of the Charité, Humboldt University of Berlin, Germany
    Am J Pathol 161:1679-93. 2002
    ..Ang II induces dendritic migration directly, whereas in vivo TNF-alpha is involved in dendritic cell infiltration and maturation. Thus, Ang II may initiate events leading to innate and acquired immune response...
  78. ncbi Phenotypical evidence for a gender difference in cardiac norepinephrine transporter function
    Christoph Schroeder
    Franz Volhard Clinical Research Center, Haus 129, Medical Faculty of the Charité Campus Buch, Wiltbergstrasse 50, 13125 Berlin, Germany
    Am J Physiol Regul Integr Comp Physiol 286:R851-6. 2004
    ..Our observations suggest that the NET contribution to cardiac norepinephrine turnover may be decreased in women. The gender difference in NET function may not be expressed in tissues that are less NET dependent than the heart...
  79. ncbi Selective impairment in sympathetic vasomotor control with norepinephrine transporter inhibition
    Jens Tank
    Clinical Research Center, HELIOS Klinikum Berlin, Franz Volhard Clinic, Medical Faculty of the Charite, Humboldt University, 13125 Berlin, Germany
    Circulation 107:2949-54. 2003
    ..Norepinephrine transporter (NET) inhibition increases the responsiveness to vasoactive medications and attenuates the response to sympathetic stimuli. The phenomenon may be a result of impaired regulation of sympathetic vasomotor tone...
  80. ncbi Association of the serum and glucocorticoid regulated kinase (sgk1) gene with QT interval
    Andreas Busjahn
    Franz Volhard Clinic, HELIOS Kliniken Berlin and Max Delbrück Center for Molecular Medicine, Medical Faculty of the Charite, Humboldt University of Berlin, Germany
    Cell Physiol Biochem 14:135-42. 2004
    ..We conclude that the regulation of KCNE1/KCNQ1 by SGK1 is similarly relevant for the repolarization of cardiac myocytes as for regulation of renal ENaC activity and blood pressure control...
  81. ncbi Regulator of G protein signalling 2 ameliorates angiotensin II-induced hypertension in mice
    Hantz C Hercule
    Max Delbruck Center for Molecular Medicine, Berlin, Germany
    Exp Physiol 92:1014-22. 2007
    ..Our findings suggest that RGS2 deletion promotes Ang II-dependent hypertension primarily through an increase of myogenic tone and vasoreactivity, probably by sensitization of AT(1) receptors...
  82. ncbi Angiotensin II-induced sudden arrhythmic death and electrical remodeling
    Robert Fischer
    Medical Faculty of the Charite, Franz Volhard Clinic HELIOS Klinikum, Wiltberg Strasse 50, 13125 Berlin, Germany
    Am J Physiol Heart Circ Physiol 293:H1242-53. 2007
    ..Untreated dTGR show electrical remodeling and probably die from VT. Los treatment reduces myocardial remodeling and predisposition to arrhythmias. ANG II target organ damage induces VT...
  83. ncbi Influences of norepinephrine transporter function on the distribution of sympathetic activity in humans
    Antje F Mayer
    Franz Volhard Clinical Research Center, Medical Faculty of the Charite, Max Delbrueck Centrum, and HELIOS Klinikum, Berlin, Germany
    Hypertension 48:120-6. 2006
    ..All of these changes are physiologically relevant because they lead to corresponding changes in organ function...
  84. pmc BK channels in innate immune functions of neutrophils and macrophages
    Kirill Essin
    Department of Nephrology, Campus Virchow, Medical Faculty of the Charite, Experimental and Clinical Research Center at the Max Delbrück Center for Molecular Medicine, Berlin, Germany
    Blood 113:1326-31. 2009
    ..Based on these data, we conclude that the BK channel is not required for NADPH oxidase activity in PMNs or macrophages or for endotoxin-triggered tumor necrosis factor-alpha release and signal transduction BMDMs...
  85. ncbi Growth arrest specific protein 6 participates in DOCA-induced target-organ damage
    Joon Keun Park
    Robert Rossle Str 10, 13125 Berlin, Germany
    Hypertension 54:359-64. 2009
    ..Gas 6 appears to play a role in mineralocorticoid receptor-mediated target organ damage. Furthermore, because warfarin interferes with Gas 6 protein expression, the findings could be of clinical relevance for anticoagulant choices...
  86. ncbi Soluble epoxide hydrolase is a susceptibility factor for heart failure in a rat model of human disease
    Jan Monti
    Max Delbruck Center for Molecular Medicine, Robert Rossle Strasse 10, 13125 Berlin, Germany
    Nat Genet 40:529-37. 2008
    ..We further demonstrated differential regulation of EPHX2 in human heart failure, suggesting a cross-species role for Ephx2 in this complex disease...
  87. ncbi Inducible NOS inhibition, eicosapentaenoic acid supplementation, and angiotensin II-induced renal damage
    Jurgen Theuer
    Medical Faculty of the Charite, Franz Volhard Clinic HELIOS Klinikum Berlin, Berlin, Germany
    Kidney Int 67:248-58. 2005
    ....
  88. ncbi (Pro)renin receptor peptide inhibitor "handle-region" peptide does not affect hypertensive nephrosclerosis in Goldblatt rats
    Dominik N Muller
    Medical Faculty of the Charite, Experimental and Clinical Research Center, Franz Volhard Clinic, and HELIOS Klinikum Berlin Buch, and Max Delbruck Center for Molecular Medicine, Berlin Buch, Germany
    Hypertension 51:676-81. 2008
    ..Our results indicate that blockade of the (P)RR with HRP does not improve target organ damage in renovascular hypertensive rats...
  89. ncbi Dietary n-3 polyunsaturated fatty acids and direct renin inhibition improve electrical remodeling in a model of high human renin hypertension
    Robert Fischer
    Medical Faculty of the Charite, Experimental and Clinical Research Center, Franz Volhard Clinic and HELIOS Klinikum Berlin Buch, Berlin, Germany
    Hypertension 51:540-6. 2008
    ..Thus, n-3 PUFAs and aliskiren improved electrical remodeling, arrhythmia induction, and connexin 43 expression, despite a 70-mm Hg difference in blood pressure and the development of cardiac hypertrophy...
  90. ncbi Paradoxical effect of sibutramine on autonomic cardiovascular regulation in obese hypertensive patients--sibutramine and blood pressure
    Andreas L Birkenfeld
    Franz Volhard Clinical Research Center, Medical Faculty of the Charité and HELIOS Klinikum, Berlin, Germany
    Clin Auton Res 15:200-6. 2005
    ..This notion has not been tested in overweight and obese patients...
  91. pmc C5a receptor mediates neutrophil activation and ANCA-induced glomerulonephritis
    Adrian Schreiber
    Medical Faculty of the Charite, Department of Nephrology and Hypertension, Franz Volhard Clinic at the Max Delbrück Center for Molecular Medicine, HELIOS Klinikum Berlin, Berlin, Germany
    J Am Soc Nephrol 20:289-98. 2009
    ..05). In summary, C5a and the neutrophil C5aR may compose an amplification loop for ANCA-mediated neutrophil activation. The C5aR may provide a new therapeutic target for ANCA-induced necrotizing crescentic glomerulonephritis...
  92. doi Norepinephrine transporter inhibition alters the hemodynamic response to hypergravitation
    Sebastian Strempel
    Franz Volhard Clinical Research Center, Medical University Charité, Campus Buch, Wiltbergstrasse 50, Haus 129, Berlin, Germany
    J Appl Physiol (1985) 104:756-60. 2008
    ..Redistribution of sympathetic activity to the heart or changes in baroreflex responses could explain the excessive tachycardia that we observed...
  93. ncbi AT1 receptor agonistic antibodies from preeclamptic patients stimulate NADPH oxidase
    Ralf Dechend
    HELIOS Klinikum Berlin, Franz Volhard Clinic and the Max Delbrück Center for Molecular Medicine, Humboldt University of Berlin, Germany
    Circulation 107:1632-9. 2003
    ..To elucidate their role further, we studied the effects of AT1-AA on reactive oxygen species (ROS), NADPH oxidase expression, and nuclear factor-kappaB (NF-kappaB) activation...
  94. ncbi Alpha-2 adrenergic transmission and human baroreflex regulation
    Jens Tank
    Department of Nephrology and Hypertension, Franz Volhard Clinic, Medical Faculty of the Charité and HELIOS Klinikum, Berlin, Germany
    Hypertension 43:1035-41. 2004
    ..alpha-2 Adrenoceptor stimulation greatly augments baroreflex-mediated bradycardia, most likely by parasympathetic activation...
  95. ncbi Endothelial dysfunction and elevated blood pressure in MAS gene-deleted mice
    Ping Xu
    Max Delbruck Center for Molecular Medicine, Robert Rossle Str 10, D 13125 Berlin Buch, Germany
    Hypertension 51:574-80. 2008
    ....
  96. ncbi Hormonal regulation of the human adipose-tissue renin-angiotensin system: relationship to obesity and hypertension
    Kerstin Gorzelniak
    Helios Klinkum Berlin, Franz Volhard Clinic Charité and Max Delbrück Center for Molecular Medicine, Humboldt University of Berlin, Germany
    J Hypertens 20:965-73. 2002
    ..The aim of this work was to study the expression of renin-angiotensin system genes in adipose tissue of obese hypertensive subjects and the hormonal regulation of these genes...
  97. ncbi Yohimbine attenuates baroreflex-mediated bradycardia in humans
    Jens Tank
    Franz Volhard Clinical Research Center, Medical Faculty of the Charité and HELIOS Klinikum, Berlin, Germany
    Hypertension 50:899-903. 2007
    ..In contrast, yohimbine did not alter the sympathetic baroreflex curve. Yohimbine selectively attenuates baroreflex heart rate control in normotensive young men possibly through parasympathetic mechanisms...
  98. ncbi Association between adiponectin and mediators of inflammation in obese women
    Stefan Engeli
    HELIOS Klinikum Berlin, Franz Volhard Clinic, Medical Faculty of the Charite, Humboldt University of Berlin, Germany
    Diabetes 52:942-7. 2003
    ....
  99. ncbi P450-dependent arachidonic acid metabolism and angiotensin II-induced renal damage
    Eva Kaergel
    Max Delbrück Center for Molecular Medicine and Franz Volhard Clinic, HELIOS Kliniken Berlin, Medical Faculty of the Charite, Humboldt University of Berlin, Germany
    Hypertension 40:273-9. 2002
    ..Because the products of AA epoxygenation have anti-inflammatory properties, this alteration may contribute to uncontrolled renal inflammation, which is a major cause of renal damage in dTGR...
  100. ncbi Complement activation in angiotensin II-induced organ damage
    Erdenechimeg Shagdarsuren
    Medical Faculty of the Charite, Franz Volhard Clinic, and HELIOS Klinikum Berlin, Germany
    Circ Res 97:716-24. 2005
    ..VSMC from dTGR are more sensitive for C3 activation. Our data show that, in this Ang II-induced model, complement activation is a major participant and suggest that TNF-alpha and CRP may play a role in its induction...
  101. ncbi Mature adipocytes inhibit in vitro differentiation of human preadipocytes via angiotensin type 1 receptors
    Jurgen Janke
    Max Delbruck Center for Molecular Medicine, HELIOS Klinikum Berlin, Franz Volhard Clinic, Medical Faculty of the Charite, Humboldt University of Berlin, Berlin, Germany
    Diabetes 51:1699-707. 2002
    ..Because AGT secretion and Ang II generation are characteristic features of adipogenesis, we postulate a paracrine negative-feedback loop that inhibits further recruitment of preadipocytes by maturing adipocytes...