Detlev Ganten

Summary

Affiliation: Humboldt University
Country: Germany

Publications

  1. pmc Management of high-risk patients with hypertension and left ventricular hypertrophy in Germany: differences between cardiac specialists in the inpatient and outpatient setting
    Heinz Völler
    Klinik am See, Seestrasse 84, D 15562 Rüdersdorf bei Berlin, Germany
    BMC Public Health 6:256. 2006
  2. pmc Posttransplantation malignancy in a patient presenting with weight loss and changed bowel habits: a case report
    Roland Schmitt
    Medical Faculty of the Charite, Franz Volhard Clinic, HELIOS Klinikum Berlin, Germany
    BMC Nephrol 7:9. 2006
  3. pmc Angiotensin II induced inflammation in the kidney and in the heart of double transgenic rats
    Juergen Theuer
    Franz Volhard Clinic, Charite and Max Delbrück Center for Molecular Medicine, Berlin, Humboldt University of Berlin, Germany
    BMC Cardiovasc Disord 2:3. 2002
  4. ncbi Freely associating with chemokine receptor 2 polymorphisms and atherosclerosis
    F C Luft
    Humboldt University of Berlin, Germany
    J Mol Med (Berl) 81:333-5. 2003
  5. ncbi Geneticism of essential hypertension
    Friedrich C Luft
    Medical Faculty of the Charite, Franz Volhard Clinic HELIOS Klinikum Berlin and Max Delbrück Center for Molecular Medicine, Berlin, Germany
    Hypertension 43:1155-9. 2004
  6. ncbi After chylomicron remnants, what is left?
    Friedrich C Luft
    Franz Volhard Clinic, HELIOS Kliniken Berlin, Medical Faculty of the Charite, Humboldt University, Wiltbergstrasse 50, 13125, Berlin Buch, Germany
    J Mol Med (Berl) 82:411-3. 2004
  7. ncbi Hypertensive nephrosclerosis: update
    Friedrich C Luft
    Franz Volhard Clinic, Medical Faculty of the Charite, HELIOS Klinikum, Berlin, Germany
    Curr Opin Nephrol Hypertens 13:147-54. 2004
  8. ncbi Cardiac reconstruction in the Jurassic Period
    Friedrich C Luft
    Franz Volhard Clinic, HELIOS Kliniken Berlin, Medical Faculty of the Charite, Humboldt University, Wiltbergstrasse 50, 13125 Berlin Buch, Germany
    J Mol Med (Berl) 82:485-7. 2004
  9. ncbi Liver stage antigen and malaria
    Friedrich C Luft
    Franz Volhard Clinic, HELIOS Kliniken Berlin, Medical Faculty of the Charite, Humboldt University, Wiltbergstrasse 50, 13125, Berlin Buch, Germany
    J Mol Med (Berl) 82:555-7. 2004
  10. ncbi The disease that never was
    Friedrich C Luft
    Franz Volhard Clinic, HELIOS Kliniken Berlin, Medical Faculty of the Charite, Humboldt University, Wiltbergstrasse 50, 13125, Berlin Buch, Germany
    J Mol Med (Berl) 82:723-4. 2004

Collaborators

Detail Information

Publications140 found, 100 shown here

  1. pmc Management of high-risk patients with hypertension and left ventricular hypertrophy in Germany: differences between cardiac specialists in the inpatient and outpatient setting
    Heinz Völler
    Klinik am See, Seestrasse 84, D 15562 Rüdersdorf bei Berlin, Germany
    BMC Public Health 6:256. 2006
    ..We aimed to investigate differences in characteristics and health care management of such patients treated as inpatients or outpatients by cardiac specialists...
  2. pmc Posttransplantation malignancy in a patient presenting with weight loss and changed bowel habits: a case report
    Roland Schmitt
    Medical Faculty of the Charite, Franz Volhard Clinic, HELIOS Klinikum Berlin, Germany
    BMC Nephrol 7:9. 2006
    ..Advancements in immunosuppressive therapy have significantly improved patient and graft survival following renal transplantation. This is paralleled by an increasing occurrence of posttransplantation malignancy...
  3. pmc Angiotensin II induced inflammation in the kidney and in the heart of double transgenic rats
    Juergen Theuer
    Franz Volhard Clinic, Charite and Max Delbrück Center for Molecular Medicine, Berlin, Humboldt University of Berlin, Germany
    BMC Cardiovasc Disord 2:3. 2002
    ..Leukocyte infiltration in the vascular wall accompanies PAI-1, MCP-1, iNOS and Tissue Factor expression. Furthermore we show evidence that Ang II causes the upregulation of NF-kB in our model...
  4. ncbi Freely associating with chemokine receptor 2 polymorphisms and atherosclerosis
    F C Luft
    Humboldt University of Berlin, Germany
    J Mol Med (Berl) 81:333-5. 2003
  5. ncbi Geneticism of essential hypertension
    Friedrich C Luft
    Medical Faculty of the Charite, Franz Volhard Clinic HELIOS Klinikum Berlin and Max Delbrück Center for Molecular Medicine, Berlin, Germany
    Hypertension 43:1155-9. 2004
  6. ncbi After chylomicron remnants, what is left?
    Friedrich C Luft
    Franz Volhard Clinic, HELIOS Kliniken Berlin, Medical Faculty of the Charite, Humboldt University, Wiltbergstrasse 50, 13125, Berlin Buch, Germany
    J Mol Med (Berl) 82:411-3. 2004
  7. ncbi Hypertensive nephrosclerosis: update
    Friedrich C Luft
    Franz Volhard Clinic, Medical Faculty of the Charite, HELIOS Klinikum, Berlin, Germany
    Curr Opin Nephrol Hypertens 13:147-54. 2004
    ..Important human and animal studies have addressed mechanistic issues regarding renal disease progression. These advances warrant detailed discussion...
  8. ncbi Cardiac reconstruction in the Jurassic Period
    Friedrich C Luft
    Franz Volhard Clinic, HELIOS Kliniken Berlin, Medical Faculty of the Charite, Humboldt University, Wiltbergstrasse 50, 13125 Berlin Buch, Germany
    J Mol Med (Berl) 82:485-7. 2004
  9. ncbi Liver stage antigen and malaria
    Friedrich C Luft
    Franz Volhard Clinic, HELIOS Kliniken Berlin, Medical Faculty of the Charite, Humboldt University, Wiltbergstrasse 50, 13125, Berlin Buch, Germany
    J Mol Med (Berl) 82:555-7. 2004
  10. ncbi The disease that never was
    Friedrich C Luft
    Franz Volhard Clinic, HELIOS Kliniken Berlin, Medical Faculty of the Charite, Humboldt University, Wiltbergstrasse 50, 13125, Berlin Buch, Germany
    J Mol Med (Berl) 82:723-4. 2004
  11. ncbi Matrix metalloproteinases and their regulators are cardiovascular therapeutic targets
    Friedrich C Luft
    Franz Volhard Clinic, HELIOS Kliniken Berlin, Medical Faculty of the Charite, Humboldt University, Wiltbergstrasse 50, 13125, Berlin Buch, Germany
    J Mol Med (Berl) 82:781-3. 2004
  12. ncbi Oscar M. Helmer, you had it right
    Friedrich C Luft
    Franz Volhard Clinic, HELIOS Kliniken Berlin, Medical Faculty of the Charite, Humboldt University, Wiltbergstrasse 50, 13125 Berlin Buch, Germany
    J Mol Med (Berl) 83:85-7. 2005
  13. pmc Sticky wickets in lower nephron nephrosis
    Friedrich C Luft
    Medical Faculty of the Charite, Franz Volhard Clinic, Helios Klinikum Berlin and Max Delbrück Center for Molecular Medicine, Germany
    J Physiol 557:703. 2004
  14. ncbi Sudden cardiac death is a very serious matter
    Friedrich C Luft
    Franz Volhard Clinic, HELIOS Kliniken Berlin, Medical Faculty of the Charite, Humboldt University, Wiltbergstrasse 50, 13125 Berlin Buch, Germany
    J Mol Med (Berl) 82:153-5. 2004
  15. ncbi Transducing proteins to manipulate intracellular targets
    Friedrich C Luft
    Franz Volhard Klinik, Humboldt University of Berlin, Wiltbergstrasse 50, 13125, Berlin Buch, Germany
    J Mol Med (Berl) 81:521-3. 2003
  16. ncbi Nectar from adipocytes
    Friedrich C Luft
    Franz Volhard Klinik, Humboldt University of Berlin, Berlin Buch, Germany
    J Mol Med (Berl) 81:389-91. 2003
  17. ncbi Mendelian hypertension with brachydactyly as a molecular genetic lesson in regulatory physiology
    Friedrich C Luft
    The Clinic Research Center of the franz Volhard Clinic, University of Berlin, 13125 Berlin, Germany
    Am J Physiol Regul Integr Comp Physiol 285:R709-14. 2003
    ..Our study underscores the importance of regulatory physiology to the understanding of a complex genetic syndrome...
  18. ncbi What the lions say
    Friedrich C Luft
    Franz Volhard Klinik, Humboldt University of Berlin, Germany
    J Mol Med (Berl) 81:453-4. 2003
  19. ncbi Thinking about zinc
    Friedrich C Luft
    Franz Volhard Klinik, Humboldt University of Berlin, Wiltbergstrasse 50, 13125 Berlin Buch, Germany
    J Mol Med (Berl) 81:597-9. 2003
  20. ncbi A very phoxy business
    Friedrich C Luft
    Franz Volhard Clinic, HELIOS Kliniken Berlin, Medical Faculty of the Charite, Humboldt University, Wiltbergstrasse 50, 13125 Berlin Buch, Germany
    J Mol Med (Berl) 82:1-3. 2004
  21. ncbi What clinicians should know about SV40 large T antigen and nucleocytoplasmic transport
    Friedrich C Luft
    Franz Volhard Clinic, HELIOS Klinikum Berlin, Medical Faculty of the Charite, Humboldt University, 13125 Berlin Buch, Germany
    J Mol Med (Berl) 81:675-7. 2003
  22. ncbi Would a vitamin help, doctor?
    Friedrich C Luft
    Franz Volhard Clinic, HELIOS Kliniken Berlin, Medical Faculty of the Charite, Humboldt University, Wiltbergstrasse 50, 13125, Berlin Buch, Germany
    J Mol Med (Berl) 82:71-3. 2004
  23. ncbi Phosphate's fate made easier
    Friedrich C Luft
    Franz Volhard Clinic, HELIOS Kliniken Berlin, Medical Faculty of the Charite, Humboldt University, Wiltbergstrasse 50, 13125 Berlin Buch, Germany
    J Mol Med (Berl) 83:1-2. 2005
  24. ncbi Abrupt hypokalemia with paralysis from a clinician's perspective
    Friedrich C Luft
    Franz Volhard Clinic, HELIOS Kliniken Berlin, Medical Faculty of the Charite, Humboldt University, Wiltbergstrasse 50, 13125, Berlin Buch, Germany
    J Mol Med (Berl) 83:167-9. 2005
  25. ncbi Somatic DNA oxidative damage and coronary disease
    Friedrich C Luft
    Franz Volhard Clinic, HELIOS Kliniken Berlin, Medical Faculty of the Charite, Humboldt University, Wiltbergstrasse 50, 13125 Berlin Buch, Germany
    J Mol Med (Berl) 83:241-3. 2005
  26. ncbi Genetic mutation screening for the low-density lipoprotein receptor
    Friedrich C Luft
    Franz Volhard Clinic, HELIOS Kliniken Berlin, Medical Faculty of the Charite, Humboldt University, Wiltbergstrasse 50, 13125 Berlin Buch, Germany
    J Mol Med (Berl) 84:183-4. 2006
  27. ncbi The cathepsins contribute to life and death in the placenta
    Friedrich C Luft
    Franz Volhard Clinic, HELIOS Kliniken Berlin, Medical Faculty of the Charite, Humboldt University, Berlin Buch, Germany
    J Mol Med (Berl) 84:259-61. 2006
  28. ncbi Suicidal erythrocyte death occurs in the hemolytic uremic syndrome
    Friedrich C Luft
    Franz Volhard Clinic, HELIOS Kliniken Berlin, Medical Faculty of the Charite, Humboldt University, Wiltbergstrasse 50, 13125 Berlin Buch, Germany
    J Mol Med (Berl) 84:347-8. 2006
  29. ncbi The jolly gentle giant titin explains Frank and Starling
    Friedrich C Luft
    Franz Volhard Clinic, HELIOS Kliniken Berlin, Medical Faculty of the Charite, Humboldt University, Wiltbergstrasse 50, 13125, Berlin Buch, Germany
    J Mol Med (Berl) 84:443-5. 2006
  30. ncbi Are human CETP mutations and CETP-inhibiting drugs a good or a bad deal?
    Friedrich C Luft
    Franz Volhard Clinic, HELIOS Kliniken Berlin, Medical Faculty of the Charite, Humboldt University, Wiltbergstrasse 50, 13125 Berlin Buch, Germany
    J Mol Med (Berl) 84:625-7. 2006
  31. ncbi On Fever, famine, and war--but mostly fever
    Friedrich C Luft
    Franz Volhard Clinic, HELIOS Kliniken Berlin Medical Faculty of the Charité, Humboldt University, Wiltbergstrasse 50, 13125, Berlin Buch, Germany
    J Mol Med (Berl) 84:799-801. 2006
  32. ncbi A high mobility group box-containing transcription factor leads to diabetes risk
    Friedrich C Luft
    Franz Volhard Clinic, HELIOS Kliniken Berlin, Medical Faculty of the Charite, Humboldt University, Berlin Buch, Germany
    J Mol Med (Berl) 84:985-7. 2006
  33. ncbi Better days are coming for Riley-Day patients
    F C Luft
    Franz Volhard Clinic, Helios, Kliniken Berlin Medical Faculty of the Charité, Humboldt University, Wiltbergstrasse 50, 13125 Berlin Buch, Germany
    J Mol Med (Berl) 85:99-101. 2007
  34. ncbi A fat attack occurred in fat city
    Friedrich C Luft
    Franz Volhard Clinic, HELIOS Kliniken Berlin, Medical Faculty of the Charite, Humboldt University, 13125 Berlin Buch, Germany
    J Mol Med (Berl) 84:1-3. 2006
  35. ncbi Light shed on the common skin scourge, psoriasis
    Friedrich C Luft
    Franz Volhard Clinic, HELIOS Kliniken Berlin, Medical Faculty of the Charite, Humboldt University, Wiltbergstrasse 50, 13125, Berlin Buch, Germany
    J Mol Med (Berl) 83:933-4. 2005
  36. ncbi Is imprinting in printing or in press?
    Friedrich C Luft
    Franz Volhard Clinic, HELIOS Kliniken Berlin, Medical Faculty of the Charite, Humboldt University, Wiltbergstrasse 50, 13125 Berlin Buch, Germany
    J Mol Med (Berl) 83:321-3. 2005
  37. ncbi More reactive and less reactive C-reactive protein
    Friedrich C Luft
    Franz Volhard Clinic, HELIOS Kliniken Berlin, Medical Faculty of the Charite, Humboldt University, Wiltbergstrasse 50, 13125 Berlin Buch, Germany
    J Mol Med (Berl) 83:411-2. 2005
  38. pmc Mendelian forms of human hypertension and mechanisms of disease
    Friedrich C Luft
    Franz Volhard Clinic HELIOS Klinikum Berlin and Max Delbrück Center for Molecular Medicine, Medical Faculty of the Charite, Humboldt University of Berlin, Germany
    Clin Med Res 1:291-300. 2003
    ..Finally, at least 5 different genes have been described that when mutated can cause pheochromocytoma. Thus, the elucidation of Mendelian blood pressure-regulatory disorders has been a resounding success...
  39. ncbi Pancaspase and cardiac function after infarction
    Friedrich C Luft
    Franz Volhard Clinic, HELIOS Kliniken Berlin, Medical Faculty of the Charite, Humboldt University, Wiltbergstrasse 50, 13125 Berlin Buch, Germany
    J Mol Med (Berl) 83:497-9. 2005
  40. ncbi NOD takes its toll but stays in the CARDs in Crohn's disease
    Friedrich C Luft
    Franz Volhard Clinic, HELIOS Kliniken Berlin, Medical Faculty of the Charite, Humboldt University, Wiltbergstrasse 50, 13125, Berlin Buch, Germany
    J Mol Med (Berl) 83:577-8. 2005
  41. ncbi Rocking around the clock, while time is relative
    Friedrich C Luft
    Franz Volhard Clinic, HELIOS Kliniken Berlin, Medical Faculty of the Charite, Humboldt University, Wiltbergstrasse 50, 13125, Berlin Buch, Germany
    J Mol Med (Berl) 83:655-6. 2005
  42. ncbi How complex is Complex I?
    Friedrich C Luft
    Franz Volhard Clinic, HELIOS Kliniken Berlin, Medical Faculty of the Charite, Humboldt University, Germany
    J Mol Med (Berl) 83:749-51. 2005
  43. ncbi Preeclampsia, Eve, and Adam join forces
    Friedrich C Luft
    Franz Volhard Clinic, HELIOS Kliniken Berlin, Medical Faculty of the Charite, Humboldt University, Wiltbergstrasse 50, 13125, Berlin Buch, Germany
    J Mol Med (Berl) 83:839-41. 2005
  44. ncbi SGK1 survival through various lives may save us all
    Friedrich C Luft
    Franz Volhard Clinic, HELIOS Kliniken Berlin, Medical Faculty of the Charite, Humboldt University, Wiltbergstrasse 50, 13125, Berlin Buch, Germany
    J Mol Med (Berl) 85:657-9. 2007
  45. ncbi The tetrapeptide N-acetyl-seryl-aspartyl-lysl-proline and angiotensin-converting enzyme
    Friedrich C Luft
    Franz Volhard Klinik, Humboldt University of Berlin, Berlin Buch, Germany
    J Mol Med (Berl) 80:461-2. 2002
  46. ncbi Proinflammatory effects of angiotensin II and endothelin: targets for progression of cardiovascular and renal diseases
    Friedrich C Luft
    HELIOS Klinikum Berlin Franz Volhard Clinic and Max Delbrück Center for Molecular Medicine, Medical Faculty of the Charite, Humboldt University of Berlin, Germany
    Curr Opin Nephrol Hypertens 11:59-66. 2002
    ..The recent elucidation of the endothelin converting enzyme's physical structure should facilitate the development of still more novel compounds to inhibit endothelin-1 generation...
  47. ncbi Workshop: mechanisms and cardiovascular damage in hypertension
    F C Luft
    Franz Volhard Clinic and Max Delbrück Center for Molecular Medicine, Medical Faculty of the Charite, Humboldt University of Berlin, Germany
    Hypertension 37:594-8. 2001
    ..Anti-inflammatory interventions may have therapeutic utility...
  48. ncbi Molecular genetics of human hypertension
    F C Luft
    Franz Volhard Clinic, Medical Faculty of the Charite, Humboldt University of Berlin, Germany
    Curr Opin Nephrol Hypertens 9:259-66. 2000
    ....
  49. ncbi Hypertension as a complex genetic trait
    Friedrich C Luft
    Franz Volhard Clinic and Max Delbrück Center for Molecular Medicine, HELIOS Klinikum, Medical Faculty of the Charite, Humboldt University of Berlin, Germany
    Semin Nephrol 22:115-26. 2002
    ..Single nucleotide polymorphisms (SNPs) permit linkage dysequilibrium mapping, which may enable cloning new genes. Thus far, very few new genes have been cloned for any complex genetic disease. The task is daunting but not impossible...
  50. ncbi Estrogen and atherosclerosis
    Friedrich C Luft
    Franz Volhard Klinik, Humboldt University of Berlin, Wiltbergstrasse 50, 13125 Berlin Buch, Germany
    J Mol Med (Berl) 80:133-4. 2002
  51. ncbi Twins in cardiovascular genetic research
    F C Luft
    Franz Volhard Clinic at the Max Delbrück Center for Molecular Medicine, Medical Faculty of the Charite, Humboldt University of Berlin, Germany
    Hypertension 37:350-6. 2001
    ..The use of single-nucleotide polymorphisms then allows for novel association approaches within the cohort. Twin studies will continue to gain in importance and utility, particularly in elucidating normal human genetic diversity...
  52. ncbi Glucocorticoid receptor function and clinical medicine
    Friedrich C Luft
    Franz Volhard Klinik, Humboldt University of Berlin, Wiltbergstrasse 50, 13125 Berlin Buch, Germany
    J Mol Med (Berl) 80:267-9. 2002
  53. ncbi Angiotensin, inflammation, hypertension, and cardiovascular disease
    F C Luft
    Franz Volhard Clinic and Max Delbrück Center for Molecular Medicine, Wiltberg Strasse 50, 13125 Berlin, Germany
    Curr Hypertens Rep 3:61-7. 2001
    ..It stimulates the proliferation of lymphocytes and contributes to their activation via calcineurin-related pathways. Knowledge of these mechanisms may provide additional therapeutic avenues...
  54. ncbi Renal disease as a risk factor for cardiovascular disease
    F C Luft
    Carité Campus Buch, Fanz Volhard Clinic, Berlin, Germany
    Basic Res Cardiol 95:I72-6. 2000
    ..Prophylactic measures known to be effective in reducing the risk from cardiovascular disease are grossly underused. Unfortunately, they are less effective in patients with renal disease, and new strategies are needed...
  55. ncbi PPARgamma and insulin sensitivity: too much and too little of a good thing
    Friedrich C Luft
    Franz Volhard Klinik, Humboldt University of Berlin, Wiltbergstrasse 50, 13125 Berlin Buch, Germany
    J Mol Med (Berl) 80:1-2. 2002
  56. ncbi Gentamicin as gene therapy
    Friedrich C Luft
    Franz Volhard Klinik, Humboldt University of Berlin, Wiltbergstrasse 50, 13125 Berlin Buch, Germany
    J Mol Med (Berl) 80:543-4. 2002
  57. ncbi Heme oxygenase-1 and mice in red, white, and blue
    Friedrich C Luft
    Franz Volhard Klinik, Humboldt University of Berlin, Wiltbergstrasse 50, 13125 Berlin Buch, Germany
    J Mol Med (Berl) 80:615-7. 2002
  58. ncbi Molecular genetics of salt-sensitivity and hypertension
    F C Luft
    Franz Volhard Clinic and Max Delbrück Center for Molecular Medicine, Medical Faculty of the Charite, Campus Buch, Humboldt University of Berlin, Germany
    Drug Metab Dispos 29:500-4. 2001
    ..New approaches are necessary to elucidate salt-sensitive hypertension. The analysis of multiple genes simultaneously in terms of a metabolic control analysis may provide a more promising approach...
  59. ncbi Haplotypes, "hyplotypes," and complex genetic disease
    Friedrich C Luft
    Franz Volhard Klinik, Humboldt University of Berlin, Wiltbergstrasse 50, 13125 Berlin Buch, Germany
    J Mol Med (Berl) 81:215-7. 2003
  60. pmc Baa, Baa, black sheep, are your kidneys full?
    Friedrich C Luft
    Franz Volhard Clinic, HELIOS Klinikum, Medical Faculty of the Charite, Humboldt University of Berlin, Wiltberg Strasse 50, 13125 Berlin, Germany
    J Physiol 549:665. 2003
  61. ncbi Salt and hypertension at the close of the millenium
    F C Luft
    Franz Volhard Clinic, Max Delbruck Center for Molecular Medicine, Medizinsche Fakultät der Charité, Humboldt University of Berlin, Federal Republic of Germany
    Wien Klin Wochenschr 110:459-66. 1998
    ..In terms of efficacy, salt restriction has not been shown superior to weight loss or a "vegetable" diet. Nonpharmacological approaches in hypertensive patients should be based on a comprehensive approach...
  62. ncbi Familial glucocorticoid deficiency syndromes
    Frederich C Luft
    Franz Volhard Klinik, Huboldt University of Berlin, Germany
    J Mol Med (Berl) 80:385-6. 2002
  63. ncbi Endothelin, nephropathy, and blood pressure
    Friedrich C Luft
    Franz Volhard Klinik, Humboldt University of Berlin, Wiltbergstrasse 50, 13125 Berlin Buch, Germany
    J Mol Med (Berl) 80:69-70. 2002
  64. ncbi Twin studies in the analysis of minor physiological differences between individuals
    Andreas Busjahn
    Franz Volhard Clinic, HELIOS Klinikum Berlin, Medical Faculty of the Charite, Humboldt University of Berlin HealthTwiSt GmbH, Berlin
    Cell Physiol Biochem 13:51-8. 2003
    ..These data, coupled with our earlier observations linking the insulin-like growth factor-1 gene locus to blood pressure lead us to conclude that the SGK1 gene is relevant to blood pressure regulation and probably to hypertension in man...
  65. ncbi Son of a mother against decapentaplegic
    F C Luft
    Franz Volhard Klinik, Humboldt University of Berlin, Wiltbergstrasse 50, 13125 Berlin Buch, Germany
    J Mol Med (Berl) 81:1-3. 2003
  66. ncbi Vascular endothelial cell-specific NF-kappaB suppression attenuates hypertension-induced renal damage
    Norbert Henke
    Medical Faculty of the Charite, Franz Volhard Clinic, HELIOS Klinikum Berlin, Germany
    Circ Res 101:268-76. 2007
    ..We conclude that in vivo NF-kappaB suppression in endothelial cells stops a signaling cascade leading to reduced hypertension-induced renal damage despite high blood pressure...
  67. pmc Immunosuppressive treatment protects against angiotensin II-induced renal damage
    Dominik N Muller
    HELIOS Klinikum Berlin, Franz Volhard Clinic and Medical Faculty of the Charité, Humboldt University of Berlin, Germany
    Am J Pathol 161:1679-93. 2002
    ..Ang II induces dendritic migration directly, whereas in vivo TNF-alpha is involved in dendritic cell infiltration and maturation. Thus, Ang II may initiate events leading to innate and acquired immune response...
  68. ncbi Selective impairment in sympathetic vasomotor control with norepinephrine transporter inhibition
    Jens Tank
    Clinical Research Center, HELIOS Klinikum Berlin, Franz Volhard Clinic, Medical Faculty of the Charite, Humboldt University, 13125 Berlin, Germany
    Circulation 107:2949-54. 2003
    ..Norepinephrine transporter (NET) inhibition increases the responsiveness to vasoactive medications and attenuates the response to sympathetic stimuli. The phenomenon may be a result of impaired regulation of sympathetic vasomotor tone...
  69. ncbi Association of the serum and glucocorticoid regulated kinase (sgk1) gene with QT interval
    Andreas Busjahn
    Franz Volhard Clinic, HELIOS Kliniken Berlin and Max Delbrück Center for Molecular Medicine, Medical Faculty of the Charite, Humboldt University of Berlin, Germany
    Cell Physiol Biochem 14:135-42. 2004
    ..We conclude that the regulation of KCNE1/KCNQ1 by SGK1 is similarly relevant for the repolarization of cardiac myocytes as for regulation of renal ENaC activity and blood pressure control...
  70. ncbi Phenotypical evidence for a gender difference in cardiac norepinephrine transporter function
    Christoph Schroeder
    Franz Volhard Clinical Research Center, Haus 129, Medical Faculty of the Charité Campus Buch, Wiltbergstrasse 50, 13125 Berlin, Germany
    Am J Physiol Regul Integr Comp Physiol 286:R851-6. 2004
    ..Our observations suggest that the NET contribution to cardiac norepinephrine turnover may be decreased in women. The gender difference in NET function may not be expressed in tissues that are less NET dependent than the heart...
  71. ncbi Angiotensin II-induced sudden arrhythmic death and electrical remodeling
    Robert Fischer
    Medical Faculty of the Charite, Franz Volhard Clinic HELIOS Klinikum, Wiltberg Strasse 50, 13125 Berlin, Germany
    Am J Physiol Heart Circ Physiol 293:H1242-53. 2007
    ..Untreated dTGR show electrical remodeling and probably die from VT. Los treatment reduces myocardial remodeling and predisposition to arrhythmias. ANG II target organ damage induces VT...
  72. ncbi Influences of norepinephrine transporter function on the distribution of sympathetic activity in humans
    Antje F Mayer
    Franz Volhard Clinical Research Center, Medical Faculty of the Charite, Max Delbrueck Centrum, and HELIOS Klinikum, Berlin, Germany
    Hypertension 48:120-6. 2006
    ..All of these changes are physiologically relevant because they lead to corresponding changes in organ function...
  73. ncbi Regulator of G protein signalling 2 ameliorates angiotensin II-induced hypertension in mice
    Hantz C Hercule
    Max Delbruck Center for Molecular Medicine, Berlin, Germany
    Exp Physiol 92:1014-22. 2007
    ..Our findings suggest that RGS2 deletion promotes Ang II-dependent hypertension primarily through an increase of myogenic tone and vasoreactivity, probably by sensitization of AT(1) receptors...
  74. ncbi Growth arrest specific protein 6 participates in DOCA-induced target-organ damage
    Joon Keun Park
    Robert Rossle Str 10, 13125 Berlin, Germany
    Hypertension 54:359-64. 2009
    ..Gas 6 appears to play a role in mineralocorticoid receptor-mediated target organ damage. Furthermore, because warfarin interferes with Gas 6 protein expression, the findings could be of clinical relevance for anticoagulant choices...
  75. pmc BK channels in innate immune functions of neutrophils and macrophages
    Kirill Essin
    Department of Nephrology, Campus Virchow, Medical Faculty of the Charite, Experimental and Clinical Research Center at the Max Delbrück Center for Molecular Medicine, Berlin, Germany
    Blood 113:1326-31. 2009
    ..Based on these data, we conclude that the BK channel is not required for NADPH oxidase activity in PMNs or macrophages or for endotoxin-triggered tumor necrosis factor-alpha release and signal transduction BMDMs...
  76. ncbi Inducible NOS inhibition, eicosapentaenoic acid supplementation, and angiotensin II-induced renal damage
    Jurgen Theuer
    Medical Faculty of the Charite, Franz Volhard Clinic HELIOS Klinikum Berlin, Berlin, Germany
    Kidney Int 67:248-58. 2005
    ....
  77. doi Soluble epoxide hydrolase is a susceptibility factor for heart failure in a rat model of human disease
    Jan Monti
    Max Delbruck Center for Molecular Medicine, Robert Rossle Strasse 10, 13125 Berlin, Germany
    Nat Genet 40:529-37. 2008
    ..We further demonstrated differential regulation of EPHX2 in human heart failure, suggesting a cross-species role for Ephx2 in this complex disease...
  78. ncbi Dietary n-3 polyunsaturated fatty acids and direct renin inhibition improve electrical remodeling in a model of high human renin hypertension
    Robert Fischer
    Medical Faculty of the Charite, Experimental and Clinical Research Center, Franz Volhard Clinic and HELIOS Klinikum Berlin Buch, Berlin, Germany
    Hypertension 51:540-6. 2008
    ..Thus, n-3 PUFAs and aliskiren improved electrical remodeling, arrhythmia induction, and connexin 43 expression, despite a 70-mm Hg difference in blood pressure and the development of cardiac hypertrophy...
  79. doi (Pro)renin receptor peptide inhibitor "handle-region" peptide does not affect hypertensive nephrosclerosis in Goldblatt rats
    Dominik N Muller
    Medical Faculty of the Charite, Experimental and Clinical Research Center, Franz Volhard Clinic, and HELIOS Klinikum Berlin Buch, and Max Delbruck Center for Molecular Medicine, Berlin Buch, Germany
    Hypertension 51:676-81. 2008
    ..Our results indicate that blockade of the (P)RR with HRP does not improve target organ damage in renovascular hypertensive rats...
  80. ncbi Paradoxical effect of sibutramine on autonomic cardiovascular regulation in obese hypertensive patients--sibutramine and blood pressure
    Andreas L Birkenfeld
    Franz Volhard Clinical Research Center, Medical Faculty of the Charité and HELIOS Klinikum, Berlin, Germany
    Clin Auton Res 15:200-6. 2005
    ..This notion has not been tested in overweight and obese patients...
  81. ncbi Mature adipocytes inhibit in vitro differentiation of human preadipocytes via angiotensin type 1 receptors
    Jurgen Janke
    Max Delbruck Center for Molecular Medicine, HELIOS Klinikum Berlin, Franz Volhard Clinic, Medical Faculty of the Charite, Humboldt University of Berlin, Berlin, Germany
    Diabetes 51:1699-707. 2002
    ..Because AGT secretion and Ang II generation are characteristic features of adipogenesis, we postulate a paracrine negative-feedback loop that inhibits further recruitment of preadipocytes by maturing adipocytes...
  82. doi Endothelial dysfunction and elevated blood pressure in MAS gene-deleted mice
    Ping Xu
    Max Delbruck Center for Molecular Medicine, Robert Rossle Str 10, D 13125 Berlin Buch, Germany
    Hypertension 51:574-80. 2008
    ....
  83. ncbi Complement activation in angiotensin II-induced organ damage
    Erdenechimeg Shagdarsuren
    Medical Faculty of the Charite, Franz Volhard Clinic, and HELIOS Klinikum Berlin, Germany
    Circ Res 97:716-24. 2005
    ..VSMC from dTGR are more sensitive for C3 activation. Our data show that, in this Ang II-induced model, complement activation is a major participant and suggest that TNF-alpha and CRP may play a role in its induction...
  84. ncbi Dissociation between adipose nitric oxide synthase expression and tissue metabolism
    Stefan Engeli
    Franz Volhard Clinical Research Center, Charite Campus Buch, Wiltbergstrasse 50, 13125 Berlin, Germany
    J Clin Endocrinol Metab 92:2706-11. 2007
    ..Nitric oxide synthase (NOS) expression in adipose tissue is increased in obese subjects. The functional relevance is not known...
  85. ncbi AT1 receptor agonistic antibodies from preeclamptic patients stimulate NADPH oxidase
    Ralf Dechend
    HELIOS Klinikum Berlin, Franz Volhard Clinic and the Max Delbrück Center for Molecular Medicine, Humboldt University of Berlin, Germany
    Circulation 107:1632-9. 2003
    ..To elucidate their role further, we studied the effects of AT1-AA on reactive oxygen species (ROS), NADPH oxidase expression, and nuclear factor-kappaB (NF-kappaB) activation...
  86. ncbi Hormonal regulation of the human adipose-tissue renin-angiotensin system: relationship to obesity and hypertension
    Kerstin Gorzelniak
    Helios Klinkum Berlin, Franz Volhard Clinic Charité and Max Delbrück Center for Molecular Medicine, Humboldt University of Berlin, Germany
    J Hypertens 20:965-73. 2002
    ..The aim of this work was to study the expression of renin-angiotensin system genes in adipose tissue of obese hypertensive subjects and the hormonal regulation of these genes...
  87. pmc C5a receptor mediates neutrophil activation and ANCA-induced glomerulonephritis
    Adrian Schreiber
    Medical Faculty of the Charite, Department of Nephrology and Hypertension, Franz Volhard Clinic at the Max Delbrück Center for Molecular Medicine, HELIOS Klinikum Berlin, Berlin, Germany
    J Am Soc Nephrol 20:289-98. 2009
    ..05). In summary, C5a and the neutrophil C5aR may compose an amplification loop for ANCA-mediated neutrophil activation. The C5aR may provide a new therapeutic target for ANCA-induced necrotizing crescentic glomerulonephritis...
  88. ncbi Alpha-2 adrenergic transmission and human baroreflex regulation
    Jens Tank
    Department of Nephrology and Hypertension, Franz Volhard Clinic, Medical Faculty of the Charité and HELIOS Klinikum, Berlin, Germany
    Hypertension 43:1035-41. 2004
    ..alpha-2 Adrenoceptor stimulation greatly augments baroreflex-mediated bradycardia, most likely by parasympathetic activation...
  89. ncbi Endothelin-converting enzyme inhibition ameliorates angiotensin II-induced cardiac damage
    Dominik N Muller
    HELIOS Klinikum Berlin, Franz Volhard Clinic and Medical Faculty of the Charité, Humboldt University of Berlin, Germany
    Hypertension 40:840-6. 2002
    ..In contrast, the ECE inhibitor treatment showed no renoprotective effect. These data are the first to show that ECE inhibition reduces angiotensin II-induced cardiac damage...
  90. doi Norepinephrine transporter inhibition alters the hemodynamic response to hypergravitation
    Sebastian Strempel
    Franz Volhard Clinical Research Center, Medical University Charité, Campus Buch, Wiltbergstrasse 50, Haus 129, Berlin, Germany
    J Appl Physiol (1985) 104:756-60. 2008
    ..Redistribution of sympathetic activity to the heart or changes in baroreflex responses could explain the excessive tachycardia that we observed...
  91. ncbi Yohimbine attenuates baroreflex-mediated bradycardia in humans
    Jens Tank
    Franz Volhard Clinical Research Center, Medical Faculty of the Charité and HELIOS Klinikum, Berlin, Germany
    Hypertension 50:899-903. 2007
    ..In contrast, yohimbine did not alter the sympathetic baroreflex curve. Yohimbine selectively attenuates baroreflex heart rate control in normotensive young men possibly through parasympathetic mechanisms...
  92. ncbi Angiotensin blockade prevents type 2 diabetes by formation of fat cells
    Arya M Sharma
    HELIOS Klinikum Berlin, Franz Volhard Clinic Charité, Humboldt University of Berlin, and Max Delbruck Center for Molecular Medicine, Berlin, Germany
    Hypertension 40:609-11. 2002
    ..Increased formation of adipocytes would counteract the ectopic deposition of lipids in other tissues (muscle, liver, pancreas), thereby improving insulin sensitivity and preventing the development of type 2 diabetes...
  93. ncbi P450-dependent arachidonic acid metabolism and angiotensin II-induced renal damage
    Eva Kaergel
    Max Delbrück Center for Molecular Medicine and Franz Volhard Clinic, HELIOS Kliniken Berlin, Medical Faculty of the Charite, Humboldt University of Berlin, Germany
    Hypertension 40:273-9. 2002
    ..Because the products of AA epoxygenation have anti-inflammatory properties, this alteration may contribute to uncontrolled renal inflammation, which is a major cause of renal damage in dTGR...
  94. ncbi Association between adiponectin and mediators of inflammation in obese women
    Stefan Engeli
    HELIOS Klinikum Berlin, Franz Volhard Clinic, Medical Faculty of the Charite, Humboldt University of Berlin, Germany
    Diabetes 52:942-7. 2003
    ....
  95. ncbi Sympathetic nerve traffic and circulating norepinephrine levels in RGS2-deficient mice
    Jens Tank
    Medical Faculty of the Charite, Franz Volhard Clinic, HELIOS Klinikum Berlin, Wiltbergstrasse 50, 13125 Berlin, Germany
    Auton Neurosci 136:52-7. 2007
    ..This observation may depend on altered coupling between electrical nerve activity and norepinephrine release and/or a changed norepinephrine uptake in RGS2-/- mice...
  96. doi Diabetic hypertensive leptin receptor-deficient db/db mice develop cardioregulatory autonomic dysfunction
    Andrey C da Costa Goncalves
    Max Delbruck Center for Molecular Medicine, Robert Rossle Strasse 10, 13125 Berlin, Germany
    Hypertension 53:387-92. 2009
    ..Our data suggest that db/db mice exhibit features found in humans with type 2 diabetic autonomic neuropathy and could serve as a model for this complication...
  97. pmc Short-term heat exposure inhibits inflammation by abrogating recruitment of and nuclear factor-{kappa}B activation in neutrophils exposed to chemotactic cytokines
    Mira Choi
    Helios Klinikum Berlin Buch, Schwanebecker Chaussee 50, 13125 Berlin, Germany
    Am J Pathol 172:367-777. 2008
    ..These new findings suggest that heat may have anti-inflammatory effects in neutrophil-dependent inflammation...
  98. doi Hormonal influences on cardiovascular norepinephrine transporter responses in healthy women
    Iryna Moldovanova
    Medical University Charité, Franz Volhard Clinical Research Center, Helios Klinikum Berlin and Max Delbrück Center for Molecular Medicine, Berlin, Germany
    Hypertension 51:1203-9. 2008
    ..The phenomenon may be explained by an effect of female sex hormones on norepinephrine transporter function, on compensatory cardiovascular responses, or both...
  99. doi Effects of circulating and local uteroplacental angiotensin II in rat pregnancy
    Lydia Hering
    HELIOS Klinikum, Schwanebecker Chaussee 50, 13125 Berlin, Germany
    Hypertension 56:311-8. 2010
    ..Conceivably, upregulation of tissue Ang II in the maternal part of the placenta represents an important growth factor for trophoblast invasion and migration...
  100. ncbi Large-conductance calcium-activated potassium channel activity is absent in human and mouse neutrophils and is not required for innate immunity
    Kirill Essin
    Department of Nephrology and Medical Intensive Care, Charite University Medicine Berlin, Humboldt University of Berlin, Germany
    Am J Physiol Cell Physiol 293:C45-54. 2007
    ..In conclusion, our experiments failed to identify functional BK channels in neutrophils. We therefore conclude that BK channels are not essential for innate immunity...
  101. ncbi p38 mitogen-activated protein kinase inhibition ameliorates angiotensin II-induced target organ damage
    Joon Keun Park
    Medical Faculty of the Charite, Franz Volhard Clinic, HELIOS Klinikum, Berlin, Germany
    Hypertension 49:481-9. 2007
    ..In conclusion, BIRB796 improved survival, target organ damage, and arrhythmogenic potential in angiotensin II-induced target organ damage...