Research Topics
Genomes and Genes | Detlev GantenSummaryAffiliation: Humboldt University Country: Germany Publications
| Collaborators
|
Detail Information
Publications
Management of high-risk patients with hypertension and left ventricular hypertrophy in Germany: differences between cardiac specialists in the inpatient and outpatient settingHeinz Völler
Klinik am See, Seestrasse 84, D 15562 Rüdersdorf bei Berlin, Germany
BMC Public Health 6:256. 2006..We aimed to investigate differences in characteristics and health care management of such patients treated as inpatients or outpatients by cardiac specialists...- Posttransplantation malignancy in a patient presenting with weight loss and changed bowel habits: a case reportRoland Schmitt
Medical Faculty of the Charite, Franz Volhard Clinic, HELIOS Klinikum Berlin, Germany
BMC Nephrol 7:9. 2006..Advancements in immunosuppressive therapy have significantly improved patient and graft survival following renal transplantation. This is paralleled by an increasing occurrence of posttransplantation malignancy... - Angiotensin II induced inflammation in the kidney and in the heart of double transgenic ratsJuergen Theuer
Franz Volhard Clinic, Charite and Max Delbrück Center for Molecular Medicine, Berlin, Humboldt University of Berlin, Germany
BMC Cardiovasc Disord 2:3. 2002..Leukocyte infiltration in the vascular wall accompanies PAI-1, MCP-1, iNOS and Tissue Factor expression. Furthermore we show evidence that Ang II causes the upregulation of NF-kB in our model... - Freely associating with chemokine receptor 2 polymorphisms and atherosclerosisF C Luft
Humboldt University of Berlin, Germany
J Mol Med 81:333-5. 2003 - Geneticism of essential hypertensionFriedrich C Luft
Medical Faculty of the Charit, , Berlin, Germany
Hypertension 43:1155-9. 2004 - After chylomicron remnants, what is left?Friedrich C Luft
Franz Volhard Clinic, HELIOS Kliniken Berlin, Medical Faculty of the Charite, Humboldt University, Wiltbergstrasse 50, 13125, Berlin Buch, Germany
J Mol Med (Berl) 82:411-3. 2004 - Hypertensive nephrosclerosis: updateFriedrich C Luft
Franz Volhard Clinic, Medical Faculty of the Charite, HELIOS Klinikum, Berlin, Germany
Curr Opin Nephrol Hypertens 13:147-54. 2004..The possibility that essential hypertension involves reduced glomerular numbers received support, as well as the theory of prenatal imprinting. Progress is being made regarding basic mechanisms and novel therapies... - Cardiac reconstruction in the Jurassic PeriodFriedrich C Luft
Franz Volhard Clinic, HELIOS Kliniken Berlin, Medical Faculty of the Charit, Humboldt University, Wiltbergstrasse 50, 13125 Berlin-Buch, Germany
J Mol Med 82:485-7. 2004 - Liver stage antigen and malariaFriedrich C Luft
Franz Volhard Clinic, HELIOS Kliniken Berlin, Medical Faculty of the Charit, Humboldt University, Wiltbergstrasse 50, 13125, Berlin-Buch, Germany
J Mol Med 82:555-7. 2004 - The disease that never wasFriedrich C Luft
Franz Volhard Clinic, HELIOS Kliniken Berlin, Medical Faculty of the Charit, Humboldt University, Wiltbergstrasse 50, 13125, Berlin-Buch, Germany
J Mol Med 82:723-4. 2004 - Matrix metalloproteinases and their regulators are cardiovascular therapeutic targetsFriedrich C Luft
Franz Volhard Clinic, HELIOS Kliniken Berlin, Medical Faculty of the Charit, Humboldt University, Wiltbergstrasse 50, 13125, Berlin-Buch, Germany
J Mol Med 82:781-3. 2004 - Oscar M. Helmer, you had it rightFriedrich C Luft
Franz Volhard Clinic, HELIOS Kliniken Berlin, Medical Faculty of the Charit, Humboldt University, Wiltbergstrasse 50, 13125 Berlin-Buch, Germany
J Mol Med 83:85-7. 2005 - Sticky wickets in lower nephron nephrosisFriedrich C Luft
Medical Faculty of the Charit, Franz Volhard Clinic, , Germany
J Physiol 557:703. 2004 - Sudden cardiac death is a very serious matterFriedrich C Luft
Franz Volhard Clinic, HELIOS Kliniken Berlin, Medical Faculty of the Charit, Humboldt University, Wiltbergstrasse 50, 13125 Berlin-Buch, Germany
J Mol Med 82:153-5. 2004 - Transducing proteins to manipulate intracellular targetsFriedrich C Luft
Franz-Volhard-Klinik, Humboldt University of Berlin, Wiltbergstrasse 50, 13125, Berlin-Buch, Germany
J Mol Med 81:521-3. 2003 - Nectar from adipocytesFriedrich C Luft
Franz-Volhard-Klinik, Humboldt University of Berlin, Berlin-Buch, Germany
J Mol Med 81:389-91. 2003 - Mendelian hypertension with brachydactyly as a molecular genetic lesson in regulatory physiologyFriedrich C Luft
The Clinic Research Center of the franz Volhard Clinic, University of Berlin, 13125 Berlin, Germany
Am J Physiol Regul Integr Comp Physiol 285:R709-14. 2003..Our study underscores the importance of regulatory physiology to the understanding of a complex genetic syndrome... - What the lions sayFriedrich C Luft
Franz-Volhard-Klinik, Humboldt University of Berlin, Germany
J Mol Med 81:453-4. 2003 - Thinking about zincFriedrich C Luft
Franz-Volhard-Klinik, Humboldt University of Berlin, Wiltbergstrasse 50, 13125 Berlin-Buch, Germany
J Mol Med 81:597-9. 2003 - A very phoxy businessFriedrich C Luft
Franz Volhard Clinic, HELIOS Kliniken Berlin, Medical Faculty of the Charit, Humboldt University, Wiltbergstrasse 50, 13125 Berlin-Buch, Germany
J Mol Med 82:1-3. 2004 - What clinicians should know about SV40 large T antigen and nucleocytoplasmic transportFriedrich C Luft
Franz Volhard Clinic, HELIOS Klinikum-Berlin, Medical Faculty of the Charit, Humboldt University, 13125 Berlin-Buch, Germany
J Mol Med 81:675-7. 2003 - Would a vitamin help, doctor?Friedrich C Luft
Franz Volhard Clinic, HELIOS Kliniken Berlin, Medical Faculty of the Charite, Humboldt University, Wiltbergstrasse 50, 13125, Berlin Buch, Germany
J Mol Med (Berl) 82:71-3. 2004 - Phosphate's fate made easierFriedrich C Luft
Franz Volhard Clinic, HELIOS Kliniken Berlin, Medical Faculty of the Charit, Humboldt University, Wiltbergstrasse 50, 13125 Berlin-Buch, Germany
J Mol Med 83:1-2. 2005 - Abrupt hypokalemia with paralysis from a clinician's perspectiveFriedrich C Luft
Franz Volhard Clinic, HELIOS Kliniken Berlin, Medical Faculty of the Charit, Humboldt University, Wiltbergstrasse 50, 13125, Berlin-Buch, Germany
J Mol Med 83:167-9. 2005 - Somatic DNA oxidative damage and coronary diseaseFriedrich C Luft
Franz Volhard Clinic, HELIOS Kliniken Berlin, Medical Faculty of the Charit, Humboldt University, Wiltbergstrasse 50, 13125 Berlin-Buch, Germany
J Mol Med 83:241-3. 2005 - Genetic mutation screening for the low-density lipoprotein receptorFriedrich C Luft
Franz Volhard Clinic, HELIOS Kliniken Berlin, Medical Faculty of the Charit, Humboldt University, Wiltbergstrasse 50, 13125 Berlin-Buch, Germany
J Mol Med 84:183-4. 2006 - The cathepsins contribute to life and death in the placentaFriedrich C Luft
Franz Volhard Clinic, HELIOS Kliniken Berlin, Medical Faculty of the Charit, Humboldt University, Berlin-Buch, Germany
J Mol Med 84:259-61. 2006 - Suicidal erythrocyte death occurs in the hemolytic uremic syndromeFriedrich C Luft
Franz Volhard Clinic, HELIOS Kliniken Berlin, Medical Faculty of the Charit, Humboldt University, Wiltbergstrasse 50, 13125 Berlin-Buch, Germany
J Mol Med 84:347-8. 2006 - The jolly gentle giant titin explains Frank and StarlingFriedrich C Luft
Franz Volhard Clinic, HELIOS Kliniken Berlin, Medical Faculty of the Charit, Humboldt University, Wiltbergstrasse 50, 13125, Berlin-Buch, Germany
J Mol Med 84:443-5. 2006 - Are human CETP mutations and CETP-inhibiting drugs a good or a bad deal?Friedrich C Luft
Franz Volhard Clinic, HELIOS Kliniken Berlin, Medical Faculty of the Charite, Humboldt University, Wiltbergstrasse 50, 13125 Berlin Buch, Germany
J Mol Med (Berl) 84:625-7. 2006 - On Fever, famine, and war--but mostly feverFriedrich C Luft
Franz Volhard Clinic, HELIOS Kliniken Berlin Medical Faculty of the Charit, Humboldt University, Wiltbergstrasse 50, 13125, Berlin-Buch, Germany
J Mol Med 84:799-801. 2006 - A high mobility group box-containing transcription factor leads to diabetes riskFriedrich C Luft
Franz Volhard Clinic, HELIOS Kliniken Berlin, Medical Faculty of the Charit, Humboldt University, Berlin-Buch, Germany
J Mol Med 84:985-7. 2006 - Better days are coming for Riley-Day patientsF C Luft
Franz Volhard Clinic, Helios, Kliniken Berlin Medical Faculty of the Charit, Humboldt University, Wiltbergstrasse 50, 13125 Berlin-Buch, Germany
J Mol Med 85:99-101. 2007 - A fat attack occurred in fat cityFriedrich C Luft
Franz Volhard Clinic, HELIOS Kliniken Berlin, Medical Faculty of the Charit, Humboldt University, 13125 Berlin-Buch, Germany
J Mol Med 84:1-3. 2006 - Light shed on the common skin scourge, psoriasisFriedrich C Luft
Franz Volhard Clinic, HELIOS Kliniken Berlin, Medical Faculty of the Charit, Humboldt University, Wiltbergstrasse 50, 13125, Berlin-Buch, Germany
J Mol Med 83:933-4. 2005 - Is imprinting in printing or in press?Friedrich C Luft
Franz Volhard Clinic, HELIOS Kliniken Berlin, Medical Faculty of the Charite, Humboldt University, Wiltbergstrasse 50, 13125 Berlin Buch, Germany
J Mol Med (Berl) 83:321-3. 2005 - More reactive and less reactive C-reactive proteinFriedrich C Luft
Franz Volhard Clinic, HELIOS Kliniken Berlin, Medical Faculty of the Charit, Humboldt University, Wiltbergstrasse 50, 13125 Berlin-Buch, Germany
J Mol Med 83:411-2. 2005 - Mendelian forms of human hypertension and mechanisms of diseaseFriedrich C Luft
Franz Volhard Clinic HELIOS Klinikum Berlin and Max Delbrück Center for Molecular Medicine, Medical Faculty of the Charite, Humboldt University of Berlin, Germany
Clin Med Res 1:291-300. 2003..Finally, at least 5 different genes have been described that when mutated can cause pheochromocytoma. Thus, the elucidation of Mendelian blood pressure-regulatory disorders has been a resounding success... - Pancaspase and cardiac function after infarctionFriedrich C Luft
Franz Volhard Clinic, HELIOS Kliniken Berlin, Medical Faculty of the Charit, Humboldt University, Wiltbergstrasse 50, 13125 Berlin-Buch, Germany
J Mol Med 83:497-9. 2005 - NOD takes its toll but stays in the CARDs in Crohn's diseaseFriedrich C Luft
Franz Volhard Clinic, HELIOS Kliniken Berlin, Medical Faculty of the Charit, Humboldt University, Wiltbergstrasse 50, 13125, Berlin-Buch, Germany
J Mol Med 83:577-8. 2005 - Rocking around the clock, while time is relativeFriedrich C Luft
Franz Volhard Clinic, HELIOS Kliniken Berlin, Medical Faculty of the Charit, Humboldt University, Wiltbergstrasse 50, 13125, Berlin-Buch, Germany
J Mol Med 83:655-6. 2005 - How complex is Complex I?Friedrich C Luft
Franz Volhard Clinic, HELIOS Kliniken Berlin, Medical Faculty of the Charite, Humboldt University, Germany
J Mol Med (Berl) 83:749-51. 2005 - Preeclampsia, Eve, and Adam join forcesFriedrich C Luft
Franz Volhard Clinic, HELIOS Kliniken Berlin, Medical Faculty of the Charit, Humboldt University, Wiltbergstrasse 50, 13125, Berlin-Buch, Germany
J Mol Med 83:839-41. 2005 - SGK1 survival through various lives may save us allFriedrich C Luft
Franz Volhard Clinic, HELIOS Kliniken Berlin, Medical Faculty of the Charit, Humboldt University, Wiltbergstrasse 50, 13125, Berlin-Buch, Germany
J Mol Med 85:657-9. 2007 - The tetrapeptide N-acetyl-seryl-aspartyl-lysl-proline and angiotensin-converting enzymeFriedrich C Luft
Franz-Volhard-Klinik, Humboldt University of Berlin, Berlin-Buch, Germany
J Mol Med 80:461-2. 2002 - Proinflammatory effects of angiotensin II and endothelin: targets for progression of cardiovascular and renal diseasesFriedrich C Luft
HELIOS Klinikum Berlin Franz Volhard Clinic and Max Delbrück Center for Molecular Medicine, Medical Faculty of the Charite, Humboldt University of Berlin, Germany
Curr Opin Nephrol Hypertens 11:59-66. 2002..The recent elucidation of the endothelin converting enzyme's physical structure should facilitate the development of still more novel compounds to inhibit endothelin-1 generation... - Workshop: mechanisms and cardiovascular damage in hypertensionF C Luft
Franz Volhard Clinic and Max Delbrück Center for Molecular Medicine, Medical Faculty of the Charite, Humboldt University of Berlin, Germany
Hypertension 37:594-8. 2001..Anti-inflammatory interventions may have therapeutic utility... - Molecular genetics of human hypertensionF C Luft
Franz Volhard Clinic, Medical Faculty of the Charite, Humboldt University of Berlin, Germany
Curr Opin Nephrol Hypertens 9:259-66. 2000.... - Hypertension as a complex genetic traitFriedrich C Luft
Franz Volhard Clinic and Max Delbrück Center for Molecular Medicine, HELIOS Klinikum, Medical Faculty of the Charite, Humboldt University of Berlin, Germany
Semin Nephrol 22:115-26. 2002..Single nucleotide polymorphisms (SNPs) permit linkage dysequilibrium mapping, which may enable cloning new genes. Thus far, very few new genes have been cloned for any complex genetic disease. The task is daunting but not impossible... - Estrogen and atherosclerosisFriedrich C Luft
Franz-Volhard-Klinik, Humboldt University of Berlin, Wiltbergstrasse 50, 13125 Berlin-Buch, Germany
J Mol Med 80:133-4. 2002 - Twins in cardiovascular genetic researchF C Luft
Franz Volhard Clinic at the Max Delbrück Center for Molecular Medicine, Medical Faculty of the Charite, Humboldt University of Berlin, Germany
Hypertension 37:350-6. 2001..The use of single-nucleotide polymorphisms then allows for novel association approaches within the cohort. Twin studies will continue to gain in importance and utility, particularly in elucidating normal human genetic diversity... - Glucocorticoid receptor function and clinical medicineFriedrich C Luft
Franz-Volhard-Klinik, Humboldt University of Berlin, Wiltbergstrasse 50, 13125 Berlin-Buch, Germany
J Mol Med 80:267-9. 2002 - Angiotensin, inflammation, hypertension, and cardiovascular diseaseF C Luft
Franz Volhard Clinic and Max Delbrück Center for Molecular Medicine, Wiltberg Strasse 50, 13125 Berlin, Germany
Curr Hypertens Rep 3:61-7. 2001..It stimulates the proliferation of lymphocytes and contributes to their activation via calcineurin-related pathways. Knowledge of these mechanisms may provide additional therapeutic avenues... - Renal disease as a risk factor for cardiovascular diseaseF C Luft
Carité Campus Buch, Fanz Volhard Clinic, Berlin, Germany
Basic Res Cardiol 95:I72-6. 2000..Prophylactic measures known to be effective in reducing the risk from cardiovascular disease are grossly underused. Unfortunately, they are less effective in patients with renal disease, and new strategies are needed... - PPARgamma and insulin sensitivity: too much and too little of a good thingFriedrich C Luft
Franz-Volhard-Klinik, Humboldt University of Berlin, Wiltbergstrasse 50, 13125 Berlin-Buch, Germany
J Mol Med 80:1-2. 2002 - Gentamicin as gene therapyFriedrich C Luft
Franz-Volhard-Klinik, Humboldt University of Berlin, Wiltbergstrasse 50, 13125 Berlin-Buch, Germany
J Mol Med 80:543-4. 2002 - Heme oxygenase-1 and mice in red, white, and blueFriedrich C Luft
Franz-Volhard-Klinik, Humboldt University of Berlin, Wiltbergstrasse 50, 13125 Berlin-Buch, Germany
J Mol Med 80:615-7. 2002 - Molecular genetics of salt-sensitivity and hypertensionF C Luft
Franz Volhard Clinic and Max Delbrück Center for Molecular Medicine, Medical Faculty of the Charite, Campus Buch, Humboldt University of Berlin, Germany
Drug Metab Dispos 29:500-4. 2001..New approaches are necessary to elucidate salt-sensitive hypertension. The analysis of multiple genes simultaneously in terms of a metabolic control analysis may provide a more promising approach... - Haplotypes, "hyplotypes," and complex genetic diseaseFriedrich C Luft
Franz-Volhard-Klinik, Humboldt University of Berlin, Wiltbergstrasse 50, 13125 Berlin-Buch, Germany
J Mol Med 81:215-7. 2003 - Baa, Baa, black sheep, are your kidneys full?Friedrich C Luft
Franz Volhard Clinic, HELIOS Klinikum, Medical Faculty of the Charite, Humboldt University of Berlin, Wiltberg Strasse 50, 13125 Berlin, Germany
J Physiol 549:665. 2003 - Salt and hypertension at the close of the milleniumF C Luft
Franz Volhard Clinic, Max Delbruck Center for Molecular Medicine, Medizinsche Fakultät der Charité, Humboldt University of Berlin, Federal Republic of Germany
Wien Klin Wochenschr 110:459-66. 1998..In terms of efficacy, salt restriction has not been shown superior to weight loss or a "vegetable" diet. Nonpharmacological approaches in hypertensive patients should be based on a comprehensive approach... - Familial glucocorticoid deficiency syndromesFrederich C Luft
Franz-Volhard-Klinik, Huboldt University of Berlin, Germany
J Mol Med 80:385-6. 2002 - Endothelin, nephropathy, and blood pressureFriedrich C Luft
Franz-Volhard-Klinik, Humboldt University of Berlin, Wiltbergstrasse 50, 13125 Berlin-Buch, Germany
J Mol Med 80:69-70. 2002 - Twin studies in the analysis of minor physiological differences between individualsAndreas Busjahn
Franz Volhard Clinic, HELIOS Klinikum Berlin, Medical Faculty of the Charite, Humboldt University of Berlin HealthTwiSt GmbH, Berlin
Cell Physiol Biochem 13:51-8. 2003..These data, coupled with our earlier observations linking the insulin-like growth factor-1 gene locus to blood pressure lead us to conclude that the SGK1 gene is relevant to blood pressure regulation and probably to hypertension in man... - Son of a mother against decapentaplegicF C Luft
Franz-Volhard-Klinik, Humboldt University of Berlin, Wiltbergstrasse 50, 13125 Berlin-Buch, Germany
J Mol Med 81:1-3. 2003 - Vascular endothelial cell-specific NF-kappaB suppression attenuates hypertension-induced renal damageNorbert Henke
Medical Faculty of the Charite, Franz Volhard Clinic, HELIOS Klinikum Berlin, Germany
Circ Res 101:268-76. 2007..We conclude that in vivo NF-kappaB suppression in endothelial cells stops a signaling cascade leading to reduced hypertension-induced renal damage despite high blood pressure... - Immunosuppressive treatment protects against angiotensin II-induced renal damageDominik N Muller
HELIOS Klinikum-Berlin, Franz Volhard Clinic and Medical Faculty of the Charit, Humboldt University of Berlin, Germany
Am J Pathol 161:1679-93. 2002..Ang II induces dendritic migration directly, whereas in vivo TNF-alpha is involved in dendritic cell infiltration and maturation. Thus, Ang II may initiate events leading to innate and acquired immune response... - Selective impairment in sympathetic vasomotor control with norepinephrine transporter inhibitionJens Tank
Clinical Research Center, HELIOS Klinikum-Berlin, Franz Volhard Clinic, Medical Faculty of the Charit, Humboldt-University, 13125 Berlin, Germany
Circulation 107:2949-54. 2003..The reduction in baroreflex buffering increases the sensitivity to vasoactive medications. Therefore, our findings represent a novel mechanism for drug interactions... - Association of the serum and glucocorticoid regulated kinase (sgk1) gene with QT intervalAndreas Busjahn
Franz Volhard Clinic, , Medical Faculty of the Charit, Humboldt University of Berlin, Germany
Cell Physiol Biochem 14:135-42. 2004..We conclude that the regulation of KCNE1/KCNQ1 by SGK1 is similarly relevant for the repolarization of cardiac myocytes as for regulation of renal ENaC activity and blood pressure control... - Phenotypical evidence for a gender difference in cardiac norepinephrine transporter functionChristoph Schroeder
Franz Volhard Clinical Research Center, Haus 129, Medical Faculty of the Charité Campus Buch, Wiltbergstrasse 50, 13125 Berlin, Germany
Am J Physiol Regul Integr Comp Physiol 286:R851-6. 2004..Our observations suggest that the NET contribution to cardiac norepinephrine turnover may be decreased in women. The gender difference in NET function may not be expressed in tissues that are less NET dependent than the heart... - Angiotensin II-induced sudden arrhythmic death and electrical remodelingRobert Fischer
Medical Faculty of the Charite, Franz Volhard Clinic HELIOS Klinikum, Wiltberg Strasse 50, 13125 Berlin, Germany
Am J Physiol Heart Circ Physiol 293:H1242-53. 2007..Untreated dTGR show electrical remodeling and probably die from VT. Los treatment reduces myocardial remodeling and predisposition to arrhythmias. ANG II target organ damage induces VT... - Influences of norepinephrine transporter function on the distribution of sympathetic activity in humansAntje F Mayer
Franz-Volhard-Clinical Research Center, Medical Faculty of the Charit, Max-Delbrueck Centrum, and HELIOS Klinikum, Berlin, Germany
Hypertension 48:120-6. 2006..All of these changes are physiologically relevant because they lead to corresponding changes in organ function... - Regulator of G protein signalling 2 ameliorates angiotensin II-induced hypertension in miceHantz C Hercule
Max Delbruck Center for Molecular Medicine, Berlin, Germany
Exp Physiol 92:1014-22. 2007..Our findings suggest that RGS2 deletion promotes Ang II-dependent hypertension primarily through an increase of myogenic tone and vasoreactivity, probably by sensitization of AT(1) receptors... - Growth arrest specific protein 6 participates in DOCA-induced target-organ damageJoon Keun Park
Robert Rossle Str 10, 13125 Berlin, Germany
Hypertension 54:359-64. 2009..Gas 6 appears to play a role in mineralocorticoid receptor-mediated target organ damage. Furthermore, because warfarin interferes with Gas 6 protein expression, the findings could be of clinical relevance for anticoagulant choices... - BK channels in innate immune functions of neutrophils and macrophagesKirill Essin
Department of Nephrology, Campus Virchow, Medical Faculty of the Charite, Experimental and Clinical Research Center at the Max Delbrück Center for Molecular Medicine, Berlin, Germany
Blood 113:1326-31. 2009..Based on these data, we conclude that the BK channel is not required for NADPH oxidase activity in PMNs or macrophages or for endotoxin-triggered tumor necrosis factor-alpha release and signal transduction BMDMs... - Inducible NOS inhibition, eicosapentaenoic acid supplementation, and angiotensin II-induced renal damageJurgen Theuer
Medical Faculty of the Charite, Franz Volhard Clinic HELIOS Klinikum Berlin, Berlin, Germany
Kidney Int 67:248-58. 2005.... - Soluble epoxide hydrolase is a susceptibility factor for heart failure in a rat model of human diseaseJan Monti
Max Delbruck Center for Molecular Medicine, Robert Rossle Strasse 10, 13125 Berlin, Germany
Nat Genet 40:529-37. 2008..We further demonstrated differential regulation of EPHX2 in human heart failure, suggesting a cross-species role for Ephx2 in this complex disease... - Dietary n-3 polyunsaturated fatty acids and direct renin inhibition improve electrical remodeling in a model of high human renin hypertensionRobert Fischer
Medical Faculty of the Charite, Experimental and Clinical Research Center, Franz Volhard Clinic and HELIOS Klinikum Berlin Buch, Berlin, Germany
Hypertension 51:540-6. 2008..Thus, n-3 PUFAs and aliskiren improved electrical remodeling, arrhythmia induction, and connexin 43 expression, despite a 70-mm Hg difference in blood pressure and the development of cardiac hypertrophy... - (Pro)renin receptor peptide inhibitor "handle-region" peptide does not affect hypertensive nephrosclerosis in Goldblatt ratsDominik N Muller
Medical Faculty of the Charite, Experimental and Clinical Research Center, Franz Volhard Clinic, and HELIOS Klinikum Berlin Buch, and Max Delbruck Center for Molecular Medicine, Berlin Buch, Germany
Hypertension 51:676-81. 2008..Our results indicate that blockade of the (P)RR with HRP does not improve target organ damage in renovascular hypertensive rats... - Paradoxical effect of sibutramine on autonomic cardiovascular regulation in obese hypertensive patients--sibutramine and blood pressureAndreas L Birkenfeld
Franz-Volhard Clinical Research Center, , Berlin, Germany
Clin Auton Res 15:200-6. 2005..These paradoxical changes are consistent with previous studies in healthy subjects and suggest a combination of peripheral and central nervous system mechanisms... - Mature adipocytes inhibit in vitro differentiation of human preadipocytes via angiotensin type 1 receptorsJurgen Janke
Max Delbruck Center for Molecular Medicine, HELIOS Klinikum Berlin, Franz Volhard Clinic, Medical Faculty of the Charite, Humboldt University of Berlin, Berlin, Germany
Diabetes 51:1699-707. 2002..Because AGT secretion and Ang II generation are characteristic features of adipogenesis, we postulate a paracrine negative-feedback loop that inhibits further recruitment of preadipocytes by maturing adipocytes... - Endothelial dysfunction and elevated blood pressure in MAS gene-deleted micePing Xu
Max Delbruck Center for Molecular Medicine, Robert Rossle Str 10, D 13125 Berlin Buch, Germany
Hypertension 51:574-80. 2008.... - Complement activation in angiotensin II-induced organ damageErdenechimeg Shagdarsuren
Medical Faculty of the Charit, Franz Volhard Clinic, and HELIOS Klinikum-Berlin, Germany
Circ Res 97:716-24. 2005..VSMC from dTGR are more sensitive for C3 activation. Our data show that, in this Ang II-induced model, complement activation is a major participant and suggest that TNF-alpha and CRP may play a role in its induction... - Dissociation between adipose nitric oxide synthase expression and tissue metabolismStefan Engeli
Franz Volhard Clinical Research Center, Charite Campus Buch, Wiltbergstrasse 50, 13125 Berlin, Germany
J Clin Endocrinol Metab 92:2706-11. 2007..Nitric oxide synthase (NOS) expression in adipose tissue is increased in obese subjects. The functional relevance is not known... - AT1 receptor agonistic antibodies from preeclamptic patients stimulate NADPH oxidaseRalf Dechend
HELIOS Klinikum-Berlin, , Humboldt University of Berlin, Germany
Circulation 107:1632-9. 2003..We suggest that AT1-AA through activation of NADPH oxidase could contribute to ROS production and inflammatory responses in preeclampsia... - Hormonal regulation of the human adipose-tissue renin-angiotensin system: relationship to obesity and hypertensionKerstin Gorzelniak
Helios Klinkum Berlin, , Humboldt University of Berlin, Germany
J Hypertens 20:965-73. 2002..The role of the adipose-tissue renin-angiotensin system in the development of obesity-associated hypertension or metabolic disease clearly warrants further study... - C5a receptor mediates neutrophil activation and ANCA-induced glomerulonephritisAdrian Schreiber
Medical Faculty of the Charite, Department of Nephrology and Hypertension, Franz Volhard Clinic at the Max Delbrück Center for Molecular Medicine, HELIOS Klinikum Berlin, Berlin, Germany
J Am Soc Nephrol 20:289-98. 2009..05). In summary, C5a and the neutrophil C5aR may compose an amplification loop for ANCA-mediated neutrophil activation. The C5aR may provide a new therapeutic target for ANCA-induced necrotizing crescentic glomerulonephritis... - Alpha-2 adrenergic transmission and human baroreflex regulationJens Tank
Department of Nephrology and Hypertension, Franz-Volhard-Clinic, , Berlin, Germany
Hypertension 43:1035-41. 2004..alpha-2 Adrenoceptor stimulation greatly augments baroreflex-mediated bradycardia, most likely by parasympathetic activation... - Endothelin-converting enzyme inhibition ameliorates angiotensin II-induced cardiac damageDominik N Muller
HELIOS Klinikum-Berlin, Franz Volhard Clinic and Medical Faculty of the Charit, Humboldt University of Berlin, Germany
Hypertension 40:840-6. 2002..In contrast, the ECE inhibitor treatment showed no renoprotective effect. These data are the first to show that ECE inhibition reduces angiotensin II-induced cardiac damage... - Norepinephrine transporter inhibition alters the hemodynamic response to hypergravitationSebastian Strempel
Franz Volhard Clinical Research Center, Medical University Charité, Campus Buch, Wiltbergstrasse 50, Haus 129, Berlin, Germany
J Appl Physiol 104:756-60. 2008..Redistribution of sympathetic activity to the heart or changes in baroreflex responses could explain the excessive tachycardia that we observed... - Yohimbine attenuates baroreflex-mediated bradycardia in humansJens Tank
Franz Volhard Clinical Research Center, Medical Faculty of the Charité and HELIOS Klinikum, Berlin, Germany
Hypertension 50:899-903. 2007..In contrast, yohimbine did not alter the sympathetic baroreflex curve. Yohimbine selectively attenuates baroreflex heart rate control in normotensive young men possibly through parasympathetic mechanisms... - Angiotensin blockade prevents type 2 diabetes by formation of fat cellsArya M Sharma
HELIOS Klinikum Berlin, Franz Volhard Clinic Charité, Humboldt University of Berlin, and Max Delbruck Center for Molecular Medicine, Berlin, Germany
Hypertension 40:609-11. 2002..Increased formation of adipocytes would counteract the ectopic deposition of lipids in other tissues (muscle, liver, pancreas), thereby improving insulin sensitivity and preventing the development of type 2 diabetes... - P450-dependent arachidonic acid metabolism and angiotensin II-induced renal damageEva Kaergel
, HELIOS Kliniken-Berlin, Medical Faculty of the Charit, Humboldt University of Berlin, Germany
Hypertension 40:273-9. 2002..Because the products of AA epoxygenation have anti-inflammatory properties, this alteration may contribute to uncontrolled renal inflammation, which is a major cause of renal damage in dTGR... - Association between adiponectin and mediators of inflammation in obese womenStefan Engeli
HELIOS Klinikum Berlin, Franz Volhard Clinic, Medical Faculty of the Charite, Humboldt University of Berlin, Germany
Diabetes 52:942-7. 2003.... - Sympathetic nerve traffic and circulating norepinephrine levels in RGS2-deficient miceJens Tank
Medical Faculty of the Charite, Franz Volhard Clinic, HELIOS Klinikum Berlin, Wiltbergstrasse 50, 13125 Berlin, Germany
Auton Neurosci 136:52-7. 2007..This observation may depend on altered coupling between electrical nerve activity and norepinephrine release and/or a changed norepinephrine uptake in RGS2-/- mice... - Diabetic hypertensive leptin receptor-deficient db/db mice develop cardioregulatory autonomic dysfunctionAndrey C da Costa Goncalves
Max Delbruck Center for Molecular Medicine, Robert Rossle Strasse 10, 13125 Berlin, Germany
Hypertension 53:387-92. 2009..Our data suggest that db/db mice exhibit features found in humans with type 2 diabetic autonomic neuropathy and could serve as a model for this complication... - Short-term heat exposure inhibits inflammation by abrogating recruitment of and nuclear factor-{kappa}B activation in neutrophils exposed to chemotactic cytokinesMira Choi
Helios Klinikum Berlin Buch, Schwanebecker Chaussee 50, 13125 Berlin, Germany
Am J Pathol 172:367-777. 2008..These new findings suggest that heat may have anti-inflammatory effects in neutrophil-dependent inflammation... - Hormonal influences on cardiovascular norepinephrine transporter responses in healthy womenIryna Moldovanova
Medical University Charité, Franz Volhard Clinical Research Center, Helios Klinikum Berlin and Max Delbrück Center for Molecular Medicine, Berlin, Germany
Hypertension 51:1203-9. 2008..The phenomenon may be explained by an effect of female sex hormones on norepinephrine transporter function, on compensatory cardiovascular responses, or both... - Effects of circulating and local uteroplacental angiotensin II in rat pregnancyLydia Hering
HELIOS Klinikum, Schwanebecker Chaussee 50, 13125 Berlin, Germany
Hypertension 56:311-8. 2010..Conceivably, upregulation of tissue Ang II in the maternal part of the placenta represents an important growth factor for trophoblast invasion and migration... - Large-conductance calcium-activated potassium channel activity is absent in human and mouse neutrophils and is not required for innate immunityKirill Essin
Department of Nephrology and Medical Intensive Care, Charite University Medicine Berlin, Humboldt University of Berlin, Germany
Am J Physiol Cell Physiol 293:C45-54. 2007..In conclusion, our experiments failed to identify functional BK channels in neutrophils. We therefore conclude that BK channels are not essential for innate immunity... - p38 mitogen-activated protein kinase inhibition ameliorates angiotensin II-induced target organ damageJoon Keun Park
Medical Faculty of the Charite, Franz Volhard Clinic, HELIOS Klinikum, Berlin, Germany
Hypertension 49:481-9. 2007..In conclusion, BIRB796 improved survival, target organ damage, and arrhythmogenic potential in angiotensin II-induced target organ damage...