Jurgen Gallinat

Summary

Affiliation: Humboldt University
Country: Germany

Publications

  1. ncbi request reprint DTNBP1 (dysbindin) gene variants: in vivo evidence for effects on hippocampal glutamate status
    C Wirth
    Charite University Medicine Berlin, Campus Mitte, Clinic for Psychiatry and Psychotherapy, 10117 Berlin, Germany
    Curr Pharm Biotechnol 13:1513-21. 2012
  2. ncbi request reprint Association of human hippocampal neurochemistry, serotonin transporter genetic variation, and anxiety
    Jurgen Gallinat
    Clinic for Psychiatry and Psychotherapy, Charite University Medicine, Berlin, Germany
    Neuroimage 26:123-31. 2005
  3. ncbi request reprint Allelic variants of the functional promoter polymorphism of the human serotonin transporter gene is associated with auditory cortical stimulus processing
    Jurgen Gallinat
    Department of Psychiatry, Free University of Berlin, Eschenallee 3, 14050 Berlin, Germany
    Neuropsychopharmacology 28:530-2. 2003
  4. ncbi request reprint Association between cerebral glutamate and human behaviour: the sensation seeking personality trait
    J Gallinat
    Department of Psychiatry and Psychotherapy, Charite University Medicine Berlin, Campus Mitte, University Hospital of Dresden, Germany
    Neuroimage 34:671-8. 2007
  5. ncbi request reprint Functional cortical effects of novel allelic variants of the serotonin transporter gene-linked polymorphic region (5-HTTLPR) in humans
    J Gallinat
    Clinic for Psychiatry and Psychotherapy, Charité Medicine Berlin, Campus Charite Mitte, Berlin, Germany
    Pharmacopsychiatry 40:191-5. 2007
  6. ncbi request reprint Smoking and structural brain deficits: a volumetric MR investigation
    Jurgen Gallinat
    Clinic for Psychiatry and Psychotherapy, Charite University Medicine, St Hedwig Krankenhaus, Turmstrasse 21, 10559 Berlin, Germany
    Eur J Neurosci 24:1744-50. 2006
  7. ncbi request reprint Genetic variations of the NR3A subunit of the NMDA receptor modulate prefrontal cerebral activity in humans
    Jurgen Gallinat
    Klinik für Psychiatrie and Psychotherapie, Charite Universitatsmedizin, Berlin
    J Cogn Neurosci 19:59-68. 2007
  8. ncbi request reprint Hippocampal glutamate concentration predicts cerebral theta oscillations during cognitive processing
    J Gallinat
    Clinic for Psychiatry and Psychotherapy PUK im SHK, Charite University Medicine Berlin, Campus Mitte, St Hedwig Krankenhaus, Turmstrasse 21, 10559 Berlin, Germany
    Psychopharmacology (Berl) 187:103-11. 2006
  9. ncbi request reprint Abnormal hippocampal neurochemistry in smokers: evidence from proton magnetic resonance spectroscopy at 3 T
    Jurgen Gallinat
    Klinik fur Psychiatrie und Psychotherapie, Charite Universitatsmedizin, Campus Mitte PUK Charité SHK, Berlin, Germany
    J Clin Psychopharmacol 27:80-4. 2007
  10. ncbi request reprint Combination of multimodal imaging and molecular genetic information to investigate complex psychiatric disorders
    J Gallinat
    Klinik fur Psychiatrie und Psychotherapie, Charite Universitatsmedizin Berlin, Campus Mitte, Berlin, Germany
    Pharmacopsychiatry 39:S76-9. 2006

Collaborators

Detail Information

Publications110 found, 100 shown here

  1. ncbi request reprint DTNBP1 (dysbindin) gene variants: in vivo evidence for effects on hippocampal glutamate status
    C Wirth
    Charite University Medicine Berlin, Campus Mitte, Clinic for Psychiatry and Psychotherapy, 10117 Berlin, Germany
    Curr Pharm Biotechnol 13:1513-21. 2012
    ....
  2. ncbi request reprint Association of human hippocampal neurochemistry, serotonin transporter genetic variation, and anxiety
    Jurgen Gallinat
    Clinic for Psychiatry and Psychotherapy, Charite University Medicine, Berlin, Germany
    Neuroimage 26:123-31. 2005
    ....
  3. ncbi request reprint Allelic variants of the functional promoter polymorphism of the human serotonin transporter gene is associated with auditory cortical stimulus processing
    Jurgen Gallinat
    Department of Psychiatry, Free University of Berlin, Eschenallee 3, 14050 Berlin, Germany
    Neuropsychopharmacology 28:530-2. 2003
    ..The LD may serve as endophenotype in human serotonin research...
  4. ncbi request reprint Association between cerebral glutamate and human behaviour: the sensation seeking personality trait
    J Gallinat
    Department of Psychiatry and Psychotherapy, Charite University Medicine Berlin, Campus Mitte, University Hospital of Dresden, Germany
    Neuroimage 34:671-8. 2007
    ..However, the role of glutamate in related personality traits like sensation seeking has not been investigated in humans...
  5. ncbi request reprint Functional cortical effects of novel allelic variants of the serotonin transporter gene-linked polymorphic region (5-HTTLPR) in humans
    J Gallinat
    Clinic for Psychiatry and Psychotherapy, Charité Medicine Berlin, Campus Charite Mitte, Berlin, Germany
    Pharmacopsychiatry 40:191-5. 2007
    ..Recent evidence indicates that the biallelic polymorphic region (S and L allele) contains additional variations affecting the mRNA expression...
  6. ncbi request reprint Smoking and structural brain deficits: a volumetric MR investigation
    Jurgen Gallinat
    Clinic for Psychiatry and Psychotherapy, Charite University Medicine, St Hedwig Krankenhaus, Turmstrasse 21, 10559 Berlin, Germany
    Eur J Neurosci 24:1744-50. 2006
    ..The present findings may explain in part the frequently reported cognitive dysfunctions in chronic cigarette consumers...
  7. ncbi request reprint Genetic variations of the NR3A subunit of the NMDA receptor modulate prefrontal cerebral activity in humans
    Jurgen Gallinat
    Klinik für Psychiatrie and Psychotherapie, Charite Universitatsmedizin, Berlin
    J Cogn Neurosci 19:59-68. 2007
    ..Because the NR3A is expressed in the human prefrontal cortex, we hypothesized that genetic variations of the NR3A subunit modulate prefrontal activation...
  8. ncbi request reprint Hippocampal glutamate concentration predicts cerebral theta oscillations during cognitive processing
    J Gallinat
    Clinic for Psychiatry and Psychotherapy PUK im SHK, Charite University Medicine Berlin, Campus Mitte, St Hedwig Krankenhaus, Turmstrasse 21, 10559 Berlin, Germany
    Psychopharmacology (Berl) 187:103-11. 2006
    ..Human evidence for such relationships is lacking...
  9. ncbi request reprint Abnormal hippocampal neurochemistry in smokers: evidence from proton magnetic resonance spectroscopy at 3 T
    Jurgen Gallinat
    Klinik fur Psychiatrie und Psychotherapie, Charite Universitatsmedizin, Campus Mitte PUK Charité SHK, Berlin, Germany
    J Clin Psychopharmacol 27:80-4. 2007
    ..In this study, proton magnetic resonance spectroscopy was used to assess the effects of chronic smoking on neuronal integrity of the hippocampus and anterior cingulate cortex (ACC)...
  10. ncbi request reprint Combination of multimodal imaging and molecular genetic information to investigate complex psychiatric disorders
    J Gallinat
    Klinik fur Psychiatrie und Psychotherapie, Charite Universitatsmedizin Berlin, Campus Mitte, Berlin, Germany
    Pharmacopsychiatry 39:S76-9. 2006
    ..To overcome the limitations of standard statistical methods, new approaches in machine learning have to be adapted to handle multiple parameters obtained from brain imaging and genetic measurements...
  11. doi request reprint Genes and neuroimaging: advances in psychiatric research
    J Gallinat
    Klinik fur Psychiatrie und Psychotherapie, Charite Universitatsmedizin Berlin, Campus Mitte, Berlin, Germany
    Neurodegener Dis 5:277-85. 2008
    ..Furthermore, recently identified putative susceptibility genes for schizophrenia (neuregulin 1, dysbindin, G72) are briefly discussed...
  12. ncbi request reprint Serotonergic effects of smoking are independent from the human serotonin transporter gene promoter polymorphism: evidence from auditory cortical stimulus processing
    J Gallinat
    Clinic for Psychiatry and Psychotherapy, Charite University Medicine, Campus Mitte, Berlin, Germany
    Pharmacopsychiatry 38:158-60. 2005
    ..Moreover, smoking behavior has been associated to the 5-HTT-genotype. It was hypothesized that cigarette smoking modulates the LD and this effect was expected to interact with the 5-HTT-genotype...
  13. ncbi request reprint No association of a functional polymorphism in the serotonin transporter gene promoter and anxiety-related personality traits
    Undine E Lang
    Department of Psychiatry, Benjamin Franklin Medical School, Free University of Berlin, Germany
    Neuropsychobiology 49:182-4. 2004
    ..f. = 2) in all subjects. Given the small effect of this 5-HTT polymorphism on behaviour in previous studies, a lack of significant genotype differences in these tests could be due to considerable individual variability in these measures...
  14. ncbi request reprint Dysfunction of ventral striatal reward prediction in schizophrenic patients treated with typical, not atypical, neuroleptics
    Georg Juckel
    Department of Psychiatry, Charite University Medical Center, Campus Charité Mitte CCM, Schumannstr 20 21, Berlin 10117, Germany
    Psychopharmacology (Berl) 187:222-8. 2006
    ..Dysfunction of the dopaminergic reward system may contribute to negative symptoms in schizophrenia...
  15. doi request reprint Reduction of auditory event-related P300 amplitude in subjects with at-risk mental state for schizophrenia
    Seza Ozgurdal
    Department of Psychiatry, Ruhr University Bochum, LWL University Hospital, Germany
    Schizophr Res 105:272-8. 2008
    ..e. before a manifestation of full-blown psychosis, and that these changes seem to have a progressive course from prodromal to chronic state of schizophrenia as assumed in this cross-sectional study...
  16. doi request reprint Met carriers of BDNF Val66Met genotype show increased N-acetylaspartate concentration in the anterior cingulate cortex
    Jurgen Gallinat
    Department of Psychiatry and Psychotherapy, Charite, University Medicine Berlin, Campus Mitte, Berlin, Germany
    Neuroimage 49:767-71. 2010
    ..We hypothesize that higher NAA levels in the ACC might contribute to the protection of Met allele carriers against major psychiatric disorders as schizophrenia and bipolar disorder...
  17. doi request reprint Switching schizophrenia patients from typical neuroleptics to aripiprazole: effects on working memory dependent functional activation
    Florian Schlagenhauf
    Department of Psychiatry, Charite Universitaetsmedizin Berlin, Campus Mitte, Germany
    Schizophr Res 118:189-200. 2010
    ..However, little is known about specific medication effects on the modulation of frontal activation during WM performance...
  18. ncbi request reprint Cortical hypoactivation during resting EEG in schizophrenics but not in depressives and schizotypal subjects as revealed by low resolution electromagnetic tomography (LORETA)
    Susanne Mientus
    Department of Psychiatry, Free University of Berlin, Berlin, Germany
    Psychiatry Res 116:95-111. 2002
    ..The results are discussed within a neurophysiological and methodological framework...
  19. doi request reprint Common structural correlates of trait impulsiveness and perceptual reasoning in adolescence
    Christina Schilling
    Department of Psychiatry and Psychotherapy, Charité University Medicine Campus Mitte, Berlin, Germany
    Hum Brain Mapp 34:374-83. 2013
    ..This study investigates whether there are common structural cerebral correlates of trait impulsiveness and cognitive functioning in a large sample of healthy adolescents from the IMAGEN project...
  20. ncbi request reprint Association of the met66 allele of brain-derived neurotrophic factor (BDNF) with smoking
    Undine E Lang
    Department of Psychiatry and Psychotherapy, University of Dresden, Fetscherstr 74, 01307, Dresden, Germany
    Psychopharmacology (Berl) 190:433-9. 2007
    ..In this study, we addressed the question if a common BDNF missense variation (Val66Met) influences the risk for smoking behavior in otherwise healthy human volunteers...
  21. doi request reprint Catechol-O-methyltransferase val158met genotype influences neural processing of reward anticipation
    Katharina Schmack
    Department of Psychiatry, Charite University Medicine, Chariteplatz 1, 10117 Berlin, Germany
    Neuroimage 42:1631-8. 2008
    ..Current evidence and our results are compatible with an interpretation that construes this effect of COMT genotype on striatal reactivity as a result of a cortico-striatal interaction...
  22. doi request reprint Neurocognitive impairments in non-deprived smokers--results from a population-based multi-center study on smoking-related behavior
    Michael Wagner
    Department of Psychiatry, University of Bonn, Germany
    Addict Biol 18:752-61. 2013
    ..The independence of these deficits from consumption intensity may argue for an a priori deficit of some cognitive abilities in smokers. These specific deficits may constitute intermediate phenotypes for genetic research on nicotine use...
  23. doi request reprint Switching schizophrenia patients from typical neuroleptics to olanzapine: effects on BOLD response during attention and working memory
    Florian Schlagenhauf
    Department of Psychiatry, Charite Universitaetsmedizin Berlin, Campus Mitte, Germany
    Eur Neuropsychopharmacol 18:589-99. 2008
    ..However, medication status had influences on the activation during attentional task (0-back), emphasizing the importance of baseline selection in pharmacological fMRI studies...
  24. doi request reprint The German multi-centre study on smoking-related behavior-description of a population-based case-control study
    Annette Lindenberg
    Department of Psychiatry, Heinrich Heine University Dusseldorf, Germany
    Addict Biol 16:638-53. 2011
    ..Study design and major population characteristics with emphasis on risk prediction of smoking status were presented in this paper...
  25. ncbi request reprint Association of the G1947A COMT (Val(108/158)Met) gene polymorphism with prefrontal P300 during information processing
    Jurgen Gallinat
    Laboratory for Clinical Psychophysiology, Department of Psychiatry, Free University, Berlin, Germany and National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA
    Biol Psychiatry 54:40-8. 2003
    ..It was predicted that homozygous Met allele carriers have a lower frontal P300 amplitude...
  26. ncbi request reprint Polymorphisms in the N-methyl-D-aspartate receptor 1 and 2B subunits are associated with alcoholism-related traits
    Catrin Wernicke
    Department of Clinical Neurobiology, University Hospital Benjamin Franklin, Free University of Berlin, Berlin, Germany
    Biol Psychiatry 54:922-8. 2003
    ..This study examined the hypothesis that allelic variants of the ionotropic glutamatergic N-methyl-D-aspartate receptor (NMDAR) are associated with vulnerability to alcoholism and some related traits...
  27. doi request reprint Psychomotor performance in relation to acute oral administration of Delta9-tetrahydrocannabinol and standardized cannabis extract in healthy human subjects
    Patrik Roser
    Department of Psychiatry, Ruhr University Bochum, Bochum, Germany
    Eur Arch Psychiatry Clin Neurosci 259:284-92. 2009
    ..This result may be due to functional changes involving GABAergic and glutamatergic neurotransmission within the corpus callosum...
  28. doi request reprint Effects of acute oral Delta9-tetrahydrocannabinol and standardized cannabis extract on the auditory P300 event-related potential in healthy volunteers
    Patrik Roser
    Department of Psychiatry, Ruhr University Bochum, Bochum, Germany
    Eur Neuropsychopharmacol 18:569-77. 2008
    ..It can be speculated whether the lack of effect of CBD may be due to an insufficient dose used or to an involvement of neurotransmitter systems in P300 generation which are not influenced by CBD...
  29. ncbi request reprint P300 subcomponents in obsessive-compulsive disorder
    Paraskevi Mavrogiorgou
    Department of Psychiatry, Section of Clinical Neurophysiology and Outpatient Clinic for Obsessive Compulsive Disorder, Ludwig Maximilians University Munich, Germany
    J Psychiatr Res 36:399-406. 2002
    ....
  30. doi request reprint Subtle deficits of cognitive theory of mind in unaffected first-degree relatives of schizophrenia patients
    Christiane Montag
    Department of Psychiatry and Psychotherapy, Charite University Medicine Berlin, Campus Mitte, Germany
    Eur Arch Psychiatry Clin Neurosci 262:217-26. 2012
    ..Findings corroborate the assumption of distinct social-cognitive abilities as an intermediate phenotype for schizophrenia...
  31. doi request reprint Serotonergic dysfunction in the prodromal, first-episode and chronic course of schizophrenia as assessed by the loudness dependence of auditory evoked activity
    Yehonala Gudlowski
    Department of Psychiatry and Psychotherapy, Charite, University Medicine of Berlin, Campus Mitte, Berlin, Germany
    Schizophr Res 109:141-7. 2009
    ..A weak LDAEP may therefore represent a vulnerability marker rather than an expression of illness progression...
  32. ncbi request reprint Loudness dependence of auditory evoked potentials is not associated with polymorphisms or haplotypes in the serotonin transporter gene in a community-based sample of German healthy volunteers
    Georg Juckel
    Department of Psychiatry, Ruhr University Bochum, Germany
    Psychiatry Res 153:183-7. 2007
    ..We speculate that the LD endophenotype depends more on genetic variations in components of the serotonergic system controlling release than on those controlling the uptake mechanism...
  33. ncbi request reprint The amygdala in schizophrenia: a trimodal magnetic resonance imaging study
    Peter Kalus
    Clinic for Psychiatry and Psychotherapy, Charite University Medicine, Campus Mitte, Psychiatrische Universitätsklinik der Charité im St Hedwig Krankenhaus, Turmstrasse 21, D 10559, Berlin, Germany
    Neurosci Lett 375:151-6. 2005
    ....
  34. ncbi request reprint Persistent dysfunctional frontal lobe activation in former smokers
    Andres Neuhaus
    Department of Psychiatry and Psychotherapy, Charite University Medicine, Campus Benjamin Franklin, Berlin, Germany
    Psychopharmacology (Berl) 186:191-200. 2006
    ..However, it is largely unknown if cerebral dysfunctions are reversible or persist during long term abstinence...
  35. doi request reprint Early orbitofrontal hyperactivation in obsessive-compulsive disorder
    Tobias Lagemann
    Department of Psychiatry and Psychotherapy, Charite, Universitatsmedizin Berlin, Campus Mitte, Chariteplatz 1, 10117 Berlin, Germany
    Psychiatry Res 202:257-63. 2012
    ..This finding might have implications for cognitive behavioural therapy of this disorder...
  36. ncbi request reprint Is the loudness dependence of auditory evoked potentials modulated by the selective serotonin reuptake inhibitor citalopram in healthy subjects?
    Idun Uhl
    Department of Psychiatry and Psychotherapy, Charite, Campus Mitte, Berlin, Germany
    Hum Psychopharmacol 21:463-71. 2006
    ..The result underlines that the acceptance of LDAEP as a marker of central serotonergic function still needs further discussion...
  37. ncbi request reprint Examining the gateway to the limbic system with diffusion tensor imaging: the perforant pathway in dementia
    Peter Kalus
    Department of Psychiatry, Charite University Medicine, Campus Mitte, Berlin, Germany
    Neuroimage 30:713-20. 2006
    ..DTI of medial temporal brain regions is a promising non-invasive tool for the in vivo diagnosis of the early/preclinical stages of AD...
  38. ncbi request reprint [Genetic and pharmacological effects on prefrontal cortical function in schizophrenia]
    Andreas Heinz
    Klinik fur Psychiatrie und Psychotherapie, Charite Campus Mitte, Charite Universitatsmedizin Berlin, Berlin
    Nervenarzt 75:845-56. 2004
    ..Molecular brain imaging combines imaging techniques with the assessment of genotype effects and represents a powerful tool for the understanding of neuropsychiatric disorders...
  39. doi request reprint Differential effects of chronic cannabis use on preattentional cognitive functioning in abstinent schizophrenic patients and healthy subjects
    Johannes Rentzsch
    Charite Universitatsmedizin Berlin, Department of Psychiatry and Psychotherapy, Campus Mitte, Chariteplatz 1, 10177 Berlin, Germany
    Schizophr Res 130:222-7. 2011
    ..In fact, there is growing evidence that cannabis-using schizophrenic patients may show preserved or even better neurocognitive performance compared to schizophrenic non-users...
  40. doi request reprint Reward feedback alterations in unmedicated schizophrenia patients: relevance for delusions
    Florian Schlagenhauf
    Department of Psychiatry and Psychotherapy, Charite Universitatsmedizin Berlin, Campus Mitte, Germany
    Biol Psychiatry 65:1032-9. 2009
    ..Increased attribution of incentive salience to neutral or aversive stimuli might be associated with dysfunction of neuronal processing of positive and negative reinforcement and contribute to the formation of delusions in schizophrenia...
  41. ncbi request reprint Serotonergic dysfunction in schizophrenia assessed by the loudness dependence measure of primary auditory cortex evoked activity
    Georg Juckel
    Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
    Schizophr Res 64:115-24. 2003
    ..These results suggest that the loudness dependence of primary auditory cortex evoked activity is well suitable to assess serotonergic dysfunction in schizophrenia...
  42. ncbi request reprint Reward system activation in schizophrenic patients switched from typical neuroleptics to olanzapine
    Florian Schlagenhauf
    Department of Psychiatry and Psychotherapy, Charite University Medical Center, Campus Charite Mitte, Chariteplatz 1, 10117 Berlin, Germany
    Psychopharmacology (Berl) 196:673-84. 2008
    ..This may not be the case with newer neuroleptics such as olanzapine, which show less dopamine D2 receptor blockade and a faster off-rate from the receptor...
  43. ncbi request reprint Association of the dopamine D2 receptor gene with alcohol dependence: haplotypes and subgroups of alcoholics as key factors for understanding receptor function
    Adrian Kraschewski
    Charite Universitatsmedizin Berlin, Klinik für Psychiatrie and Psychotherapie, Campus Benjamin Franklin, Berlin, Germany
    Pharmacogenet Genomics 19:513-27. 2009
    ..We examined the hypothesis that haplotypes composed of polymorphisms, associated with reduced receptor expression, are more frequent in alcoholics compared with healthy individuals...
  44. doi request reprint Serotonin transporter promoter polymorphism and dopaminergic sensitivity in alcoholics
    Henning Budde
    Department of Movement and Training Science, Institute of Sport Science, Humboldt University, Philippstrasse 13, 10115, Berlin, Germany
    J Neural Transm 117:133-8. 2010
    ..It is hypothesized that the reduction of sensitivity of the central DA receptors in alcoholics with the L/L genotype might be due to their higher vulnerability to the neurotoxic effects of chronic alcohol consumption than the S carriers...
  45. ncbi request reprint Association of EEG coherence and an exonic GABA(B)R1 gene polymorphism
    Georg Winterer
    Department of Psychiatry, University Hospital Benjamin Franklin, Free University of Berlin, Berlin, Germany
    Am J Med Genet B Neuropsychiatr Genet 117:51-6. 2003
    ..Since variations of EEG coherence have been described for several neuropsychiatric disorders, the present association should be tested in clinical samples using EEG coherence as an intermediate phenotype...
  46. doi request reprint COMT Val108/158Met genotype modulates human sensory gating
    Tomislav Majic
    Clinic for Psychiatry and Psychotherapy, Charite University Medicine, Campus Mitte, Berlin, Germany
    Neuroimage 55:818-24. 2011
    ..It is however unclear if COMT genotype as a predictor of prefrontal efficiency modulates sensory gating on the level of the auditory cortex, i.e. the gating of the auditory evoked P50 and N100 components...
  47. ncbi request reprint The relationship between reaction time, error rate and anterior cingulate cortex activity
    Christoph Mulert
    Laboratory for Clinical Psychophysiology, Department of Psychiatry, Free University, Berlin, Germany
    Int J Psychophysiol 47:175-83. 2003
    ..This finding suggests that increased ACC activity is associated with a gain in reaction speed at the expense of correctness and is discussed in the context of current concepts about the role of the ACC in cognitive functions...
  48. ncbi request reprint Reduced oscillatory gamma-band responses in unmedicated schizophrenic patients indicate impaired frontal network processing
    Jurgen Gallinat
    Clinic for Psychiatry and Psychotherapy, Humboldt University, Berlin, Germany
    Clin Neurophysiol 115:1863-74. 2004
    ..This is the first investigation of oscillatory activations in the gamma-band in an auditory oddball paradigm in unmedicated schizophrenic patients...
  49. doi request reprint Brain grey matter deficits in smokers: focus on the cerebellum
    Simone Kühn
    Charite University Medicine, St Hedwig Krankenhaus, Clinic for Psychiatry and Psychotherapy, Berlin, Germany
    Brain Struct Funct 217:517-22. 2012
    ..Of note, the dependence-related magnitude of the volume deficit may support the notion that the cerebellum is substantially involved in core mechanisms of drug dependence...
  50. doi request reprint Gray matter abnormalities in subjects at ultra-high risk for schizophrenia and first-episode schizophrenic patients compared to healthy controls
    Henning Witthaus
    Early Recognition and Therapy Centre for Psychoses Bochum BoFit, Department of Psychiatry, Psychotherapy and Psychosomatic Medicine, Ruhr University of Bochum, Alexandrinenstrasse 1, 44791, Germany
    Psychiatry Res 173:163-9. 2009
    ..This study provides further evidence that gray matter brain volume, especially in the anterior cingulate cortex, is already reduced in the prodromal state of schizophrenia...
  51. pmc Regional patterns and clinical correlates of basal ganglia morphology in non-medicated schizophrenia
    Martina Ballmaier
    Department of Psychiatry and Psychotherapy, Charite University Medicine, Berlin, Germany
    Schizophr Res 106:140-7. 2008
    ....
  52. ncbi request reprint Acute effects of Delta9-tetrahydrocannabinol and standardized cannabis extract on the auditory evoked mismatch negativity
    Georg Juckel
    Department of Psychiatry, University Hospital Charite, Berlin, Germany
    Schizophr Res 97:109-17. 2007
    ..This effect may be relevant for auditory cortex activity in particular because only MMN amplitudes at the central, but not at the frontal electrodes were enhanced under cannabis...
  53. doi request reprint Different aspects of theory of mind in paranoid schizophrenia: evidence from a video-based assessment
    Christiane Montag
    Charite University Medicine Berlin, Department of Psychiatry and Psychotherapy, Campus Mitte, Berlin, Germany
    Psychiatry Res 186:203-9. 2011
    ..In schizophrenic patients, negative symptoms were associated with a lack of a mental state concept, while positive symptoms like delusions were associated with 'overmentalizing', supporting respective etiological concepts of delusions...
  54. ncbi request reprint Frontal and temporal dysfunction of auditory stimulus processing in schizophrenia
    Jurgen Gallinat
    Department of Psychiatry, Free University, Berlin, Germany
    Neuroimage 17:110-27. 2002
    ..This would be in line with the notion that attention deficits in schizophrenia involve an extended cortical network...
  55. ncbi request reprint Pharmacogenetic insights to monoaminergic dysfunction in alcohol dependence
    Andreas Heinz
    Department of Psychiatry, Campus Charite Mitte, Charite University Medicine Berlin, Schumannstrasse 20 21, 10117 Berlin, Germany
    Psychopharmacology (Berl) 174:561-70. 2004
    ..The severity and time-course of recovery of these neuroadaptive changes may depend on the genetic constitution of monoamine transporters and receptors and contribute to the relapse risk of alcoholics...
  56. doi request reprint Reduction of cerebellar grey matter in Crus I and II in schizophrenia
    Simone Kühn
    Clinic for Psychiatry and Psychotherapy, St Hedwig Krankenhaus, Charite University Medicine, Campus Mitte, Berlin, Germany
    Brain Struct Funct 217:523-9. 2012
    ..The failure of conventional VBM to detect such effects suggests that previous studies might have underestimated the importance of cerebellar structural deficits in schizophrenia...
  57. ncbi request reprint Evidence for the importance of the human dopamine transporter gene for withdrawal symptomatology of alcoholics in a German population
    Catrin Wernicke
    Department of Clinical Neurobiology, Benjamin Franklin Medical School, Free University of Berlin, Ulmenallee 32, D 14050 Berlin, Germany
    Neurosci Lett 333:45-8. 2002
    ..032, OR = 4.707), and with an alcoholic mother (P = 0.021, OR = 5.250), compared to homozygote 10/10 controls. Our findings provide further evidence that the 3'UTR of the DAT1 gene affects vulnerability to severe alcohol withdrawal...
  58. doi request reprint Interaction of hippocampal volume and N-acetylaspartate concentration deficits in schizophrenia: a combined MRI and 1H-MRS study
    Andreas Arthur Klär
    Department of Psychiatry and Psychotherapy, Charite University Medicine Berlin, Campus Mitte, Berlin, Germany
    Neuroimage 53:51-7. 2010
    ..However, the possible interaction between regional NAA reduction and volume deficits has been targeted only marginally in previous investigations...
  59. doi request reprint Association between a cannabinoid receptor gene (CNR1) polymorphism and cannabinoid-induced alterations of the auditory event-related P300 potential
    Andreas M Stadelmann
    Department of Psychiatry and Psychotherapy, Charite University Hospital Berlin, Berlin, Germany
    Neurosci Lett 496:60-4. 2011
    ..Moreover, it appears that variations within CNR1 may differentially alter the sensitivity to the acute effects of cannabinoids on P300 generation in healthy subjects...
  60. ncbi request reprint Loudness dependence of the auditory evoked N1/P2 component as an indicator of serotonergic dysfunction in patients with schizophrenia--a replication study
    Georg Juckel
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University Munich, Germany
    Psychiatry Res 158:79-82. 2008
    ..Thus, we were able again to demonstrate electrophysiological evidence for an upregulated serotonergic system in schizophrenia...
  61. doi request reprint Serotonin transporter gene and adverse life events in adult ADHD
    Daniel J Muller
    Department of Psychiatry, Charite University Medicine Berlin, Campus Mitte, Berlin, Germany
    Am J Med Genet B Neuropsychiatr Genet 147:1461-9. 2008
    ..In conclusion, our data support the role of environmental factors in adult ADHD symptomatology. SERTPR may be involved in some features of the illness and act as a moderator of environmental influences in ADHD...
  62. ncbi request reprint Association analysis of GABAAbeta2 and gamma2 gene polymorphisms with event-related prefrontal activity in man
    G Winterer
    Department of Psychiatry, University Hospital Benjamin Franklin, Free University of Berlin, Germany
    Hum Genet 107:513-8. 2000
    ....
  63. ncbi request reprint Motorcortical excitability after electroconvulsive therapy in patients with major depressive disorder
    Malek Bajbouj
    Department of Psychiatry, Charite University Medicine Berlin, Campus Benjamin Franklin, Eschenallee 3, 14050 Berlin, Germany
    Suppl Clin Neurophysiol 56:433-40. 2003
  64. pmc Association between oxytocin receptor gene polymorphisms and self-rated 'empathic concern' in schizophrenia
    Christiane Montag
    Department of Psychiatry and Psychotherapy, Charite Campus Mitte, Charité University Medicine Berlin Charité Universitätsmedizin Berlin, Berlin, Germany
    PLoS ONE 7:e51882. 2012
    ..Our preliminary findings support hypotheses about an involvement of OXTR rs2254298 in emotional empathy in schizophrenic and healthy individuals, warranting independent replication...
  65. pmc Prefrontal cortex glutamate correlates with mental perspective-taking
    Christiane Montag
    Department of Psychiatry and Psychotherapy, Charite University Medicine Berlin, Campus Mitte, Berlin, Germany
    PLoS ONE 3:e3890. 2008
    ..However, the role of the glutamate system for different dimensions of empathy has not been investigated so far...
  66. doi request reprint Comparison of midlatency auditory sensory gating at short and long interstimulus intervals
    Johannes Rentzsch
    Campus Mitte, Department of Psychiatry, Charite Universitatsmedizin Berlin, Berlin, Germany
    Neuropsychobiology 58:11-8. 2008
    ..The aim of the study was to investigate whether a simple modified dual-click protocol with short interstimulus intervals elicts similar sensory gating ratios compared to the classic protocol...
  67. doi request reprint Neural correlates of impaired volitional action control in schizophrenia patients
    Julia Bender
    Department of Psychology, Humboldt Universitat zu Berlin, Berlin, Germany
    Psychophysiology 50:872-84. 2013
    ....
  68. ncbi request reprint Neurophysiological effects of cannabinoids: implications for psychosis research
    Jurgen Gallinat
    Department of Psychiatry, Charite University Medicine Berlin, Campus Charite Mitte, Berlin, Germany
    Curr Pharm Des 18:4938-49. 2012
    ....
  69. doi request reprint Higher prefrontal cortical thickness in high schizotypal personality trait
    Simone Kühn
    Charite University Medicine, St Hedwig Krankenhaus, Clinic for Psychiatry and Psychotherapy, Große Hamburger Straße 5 11, 10115 Berlin, Germany
    J Psychiatr Res 46:960-5. 2012
    ..One may speculate that this finding is in line with the hypothesis of a compensatory role of greater prefrontal cortex in schizotypy in healthy populations...
  70. doi request reprint MTR abnormalities in subjects at ultra-high risk for schizophrenia and first-episode schizophrenic patients compared to healthy controls
    Georg Bohner
    Department of Neuroradiology, Charite Campus Mitte, 10117 Berlin, Germany
    Schizophr Res 137:85-90. 2012
    ..We aimed at evaluating subtle parenchymal alterations in individuals at ultra-high risk (UHR) for transition into psychosis and first-episode schizophrenic (FES) patients by measuring the magnetization transfer ratio (MTR)...
  71. doi request reprint Manual dexterity correlating with right lobule VI volume in right-handed 14-year-olds
    Simone Kühn
    Department of Psychiatry and Psychotherapy, Charité University Medicine Campus Mitte, Berlin, Germany
    Neuroimage 59:1615-21. 2012
    ..Although neuronal cerebellar structures mediate dexterity, classical whole brain voxel-based morphometry (VBM) has not identified structural correlates of dexterity in the cerebellum...
  72. doi request reprint P50 sensory gating and smoking in the general population
    Jürgen Brinkmeyer
    Department of Psychiatry, Heinrich Heine University Dusseldorf, Bergische Landstrasse 2, Dusseldorf, Germany
    Addict Biol 16:485-98. 2011
    ..The suitability and application of sensory P50 gating as functional biomarker with regard to genetic and pharmacological studies is discussed...
  73. ncbi request reprint Molecular mechanisms of schizophrenia
    Undine E Lang
    Department of Psychiatry, Charite University Medicine Berlin, Campus Mitte, Berlin Germany
    Cell Physiol Biochem 20:687-702. 2007
    ..In a unifying hypothesis, different cascades merge into another that ultimately lead to the development of symptoms adherent to schizophrenic disorders...
  74. ncbi request reprint Association of attentional network function with exon 5 variations of the CHRNA4 gene
    Georg Winterer
    Department of Psychiatry, Henirich Heine University, Duesseldorf, Germany
    Hum Mol Genet 16:2165-74. 2007
    ..If confirmed, future studies need to address what 'functional' polymorphisms are causative for the observed effects...
  75. ncbi request reprint Test-retest reliability of P50, N100 and P200 auditory sensory gating in healthy subjects
    Johannes Rentzsch
    Department of Psychiatry, Charite Universitatsmedizin Berlin, Germany
    Int J Psychophysiol 67:81-90. 2008
    ..However, most studies only show a low reliability for P50 sensory gating and neither N100 nor P200 sensory gating have been sufficiently tested...
  76. ncbi request reprint Electrophysiological and neuropsychological analysis of a delirious state: the role of the anterior cingulate gyrus
    Friedel M Reischies
    Department of Psychiatry and Psychotherapy, Charite University Medicine Berlin, Campus Benjamin Franklin, Eschenallee 3, 14050 Berlin, Germany
    Psychiatry Res 138:171-81. 2005
    ..This dysfunction of the ACC was shown for the first time in patients during a delirious state and may represent an important pathophysiological aspect of delirium...
  77. ncbi request reprint New evidence for involvement of the entorhinal region in schizophrenia: a combined MRI volumetric and DTI study
    Peter Kalus
    Clinic for Psychiatry and Psychotherapy, Charite University Medicine, Campus Mitte, Turmstrasse 21, D 10559 Berlin, Germany
    Neuroimage 24:1122-9. 2005
    ..Combinations of different MRI modalities are a promising approach for the detection and characterization of subtle brain tissue alterations...
  78. pmc Rationale and baseline characteristics of PREVENT: a second-generation intervention trial in subjects at-risk (prodromal) of developing first-episode psychosis evaluating cognitive behavior therapy, aripiprazole, and placebo for the prevention of psychosi
    Andreas Bechdolf
    Department of Psychiatry and Psychotherapy, University of Cologne, Kerpener Str 62, 50924 Cologne, Germany
    Schizophr Bull 37:S111-21. 2011
    ..When the final results of the trial are available, PREVENT will substantially expand the current limited evidence base for best clinical practice in people at-risk (prodromal) of first-episode psychosis...
  79. doi request reprint Acute exercise ameliorates reduced brain-derived neurotrophic factor in patients with panic disorder
    Andreas Strohle
    Department of Psychiatry and Psychotherapy, Campus Charite Mitte, Charite Universitatsmedizin Berlin, Chariteplatz 1, 10117 Berlin, Germany
    Psychoneuroendocrinology 35:364-8. 2010
    ....
  80. doi request reprint Volitional saccades and attentional mechanisms in schizophrenia patients and healthy control subjects
    Benedikt Reuter
    Institut fur Psychologie, Humboldt Universitat zu Berlin, Berlin, Germany
    Psychophysiology 48:1333-9. 2011
    ..Unexpectedly, SZ patients had normal saccade latencies. Presumably, the expected deficit was compensated by decreased fixation-related neural activity, which was induced by the disappearance of fixation stimuli...
  81. ncbi request reprint BDNF serum concentrations in healthy volunteers are associated with depression-related personality traits
    Undine E Lang
    Clinic for Psychiatry and Psychotherapy, Charité Medicine Berlin, Campus Benjamin Franklin, Germany
    Neuropsychopharmacology 29:795-8. 2004
    ..These results provide further support for the hypothesis that BDNF may be central to the development of depressive mood states...
  82. ncbi request reprint The diagnostic value of clinical EEG in detecting abnormal synchronicity in panic disorder
    Michael Adamaszek
    Department of Psychiatry and Psychotherapy, University Hospital Leipzig, Germany
    Clin EEG Neurosci 42:166-74. 2011
    ..Thus, scalp EEG recordings are still recommended for discovering indications of abnormal synchronous neuronal activity in panic patients...
  83. doi request reprint Theory of mind impairments in euthymic bipolar patients
    Christiane Montag
    Klinik fur Psychiatrie und Psychotherapie, Charite Universitatsmedizin Berlin, Chariteplatz 1, 10117 Berlin, Germany
    J Affect Disord 123:264-9. 2010
    ..In bipolar affective disorder, evidence for ToM deficits is scant, although brain imaging studies and impairments in non-social neurocognitive domains indicate deficits of prefrontal functions...
  84. ncbi request reprint Venous drainage patterns in a case of pseudotumor cerebri following unilateral radical neck dissection
    Florian Doepp
    Department of Neurology, University Hospital Charite, Humboldt University, Berlin, Germany
    Acta Otolaryngol 123:994-7. 2003
    ..We conclude that the physiological collateral function of the vertebral venous system and deep neck veins was insufficient and contributed to global venous outflow obstruction in our case of unilateral rND...
  85. ncbi request reprint Markers from event-related potential subcomponents and reaction time for information processing dysfunction in schizophrenia
    T Frodl
    Department of Psychiatry, , Munich, Germany
    Eur Arch Psychiatry Clin Neurosci 248:307-13. 1998
    ..The input-related processing stages (N100 and P200) were not altered, whereas later, the deviant and task-related processes (N200, frontal P300, parietal P300 and reaction time) were significantly prolonged in schizophrenia...
  86. ncbi request reprint Loudness dependence of primary auditory-cortex-evoked activity as predictor of therapeutic outcome to prophylactic lithium treatment in affective disorders--a retrospective study
    G Juckel
    Section of Clinical Neurophysiology, Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
    Pharmacopsychiatry 37:46-51. 2004
    ....
  87. ncbi request reprint P300 and LORETA: comparison of normal subjects and schizophrenic patients
    G Winterer
    Department of Psychiatry, Free University Berlin, Germany
    Brain Topogr 13:299-313. 2001
    ..The data further suggest that the P300-deficit in schizophrenics involves an extended cortical network of the left hemisphere at several steps in time during the information processing stream...
  88. ncbi request reprint P300 is enhanced in responders to vagus nerve stimulation for treatment of major depressive disorder
    A H Neuhaus
    Department of Psychiatry and Psychotherapy, Charite University Medicine, Berlin, Germany
    J Affect Disord 100:123-8. 2007
    ..In an exploratory study, we investigated the effects of VNS on auditory event-related potentials (ERP)...
  89. ncbi request reprint Self-reported empathic abilities in schizophrenia
    C Montag
    Klinik fur Psychiatrie und Psychotherapie, Charite Universitatsmedizin Berlin, Chariteplatz 1, 10117 Berlin, Germany
    Schizophr Res 92:85-9. 2007
    ..e. cognitive aspects of mental state attribution, the ability to infer emotional experiences of others, i.e. affective empathy, has not been investigated so far...
  90. ncbi request reprint Reduced event-related current density in the anterior cingulate cortex in schizophrenia
    C Mulert
    Laboratory for Clinical Psychophysiology, Free University, Berlin, Germany
    Neuroimage 13:589-600. 2001
    ..Our data also suggest that anterior cingulate function in schizophrenics is disturbed at a relatively early time point in the information-processing stream (100-140 ms poststimulus)...
  91. doi request reprint Neurotransmitter systems in alcohol dependence
    A Heinz
    Department of Psychiatry and Psychotherapy, CCM, Charite University Medicine, Berlin, Germany
    Pharmacopsychiatry 42:S95-S101. 2009
    ..g. between brain atrophy and genes associated with glutamatergic and dopaminergic neurotransmission...
  92. doi request reprint Distinct haplogenotypes of the dopamine D2 receptor gene are associated with non-smoking behaviour and daily cigarette consumption
    C Wernicke
    Charite Universitatsmedizin Berlin, Klinische Neurobiologie, Klinik für Psychiatrie and Psychotherapie, Campus Benjamin Franklin, Berlin, Germany
    Pharmacopsychiatry 42:41-50. 2009
    ..Thus, the knowledge about the distribution of the haplotypes in groups of subjects, differing by their smoking behaviour, would result in a better understanding of the putative associations compared to single SNP investigations...
  93. ncbi request reprint Loudness dependence of auditory evoked potentials in obsessive-compulsive disorder: a pilot study
    M T Carrillo-de-la-Peña
    Department of Psychiatry, Section of Clinical Neurophysiology and Outpatient Clinic for Obsessive Compulsive Disorder, Ludwig Maximilians Universitat, Munich, Germany
    Psychiatry Res 93:209-16. 2000
    ..These findings do not support the hypothesis of a serotonergic dysfunction in OCD patients...
  94. ncbi request reprint Molecular brain imaging and the neurobiology and genetics of schizophrenia
    A Heinz
    Department of Psychiatry and Psychotherapy, Charite University Medicine Berlin, Campus Charité Mitte CCM, Berlin, Germany
    Pharmacopsychiatry 36:S152-7. 2003
    ..Molecular brain imaging can help to unravel the complex interactions between genes and environment and its association with neuronal network dysfunction in schizophrenia...
  95. doi request reprint Gender-dependent association of a functional NGF polymorphism with anxiety-related personality traits
    U E Lang
    Clinic for Psychiatry and Psychotherapy, Charité Medicine Berlin, Campus Charite Mitte, Berlin, Germany
    Pharmacopsychiatry 41:196-9. 2008
    ..Nerve growth factor (NGF) has been shown to be involved in anxiety behaviour and the expression of conditioned fear in mice...
  96. doi request reprint The concept of endophenotypes in psychiatric diseases meeting the expectations?
    I Puls
    Department of Psychiatry and Psychotherapy, Charite University Medicine, Berlin, Germany
    Pharmacopsychiatry 41:S37-43. 2008
    ..We will also summarize essential prerequisites for successful endophenotypes in the future as well as applications for psychiatric diseases which have been envisioned...
  97. doi request reprint Cortical thickness correlates with impulsiveness in healthy adults
    Christina Schilling
    Department of Psychiatry and Psychotherapy, Charité University Medicine Campus Mitte, St Hedwig Krankenhaus, Große Hamburger Str 5 11, 10115 Berlin, Germany
    Neuroimage 59:824-30. 2012
    ..This study investigates whether there are overlapping as well as distinct structural cerebral correlates of attentional, motor and nonplanning impulsiveness in healthy adults...
  98. ncbi request reprint Comparison of the amplitude/intensity function of the auditory evoked N1m and N1 components
    M Neukirch
    Laboratory of Clinical Psychophysiology, Department of Psychiatry, Free University of Berlin, Germany
    Neuropsychobiology 45:41-8. 2002
    ..The magnetic dipole shifted to the surface of the skull with higher stimulus intensity whereas the electric tangential dipole moved to the center of the skull. The latencies decreased with increasing stimulus intensity...
  99. ncbi request reprint The loudness dependency of the auditory evoked N1/P2-component as a predictor of the acute SSRI response in depression
    J Gallinat
    Department of Psychiatry, Free University Berlin, Germany
    Psychopharmacology (Berl) 148:404-11. 2000
    ..In animal and human data there is a growing amount of evidence that a strong loudness dependency of late auditory evoked potentials (LDAEP) is an indicator of low serotonergic activity and vice versa...
  100. ncbi request reprint Superior temporal gyrus and P300 in schizophrenia: a combined ERP/structural magnetic resonance imaging investigation
    E M Meisenzahl
    Department of Psychiatry, Psychiatrische Klinik der LMU München, Nussbaumstr 7, 80 336, Munich, Germany
    J Psychiatr Res 38:153-62. 2004
    ..No associations between the electrophysiological and structural measurements could be detected. There were also no significant reductions of ERP and MRI measurements within the subgroup of patients with pronounced negative symptoms...
  101. ncbi request reprint Regional cerebral glutamate concentrations and chronic tobacco consumption
    J Gallinat
    Klinik fur Psychiatrie und Psychotherapie, Charite Universitatsmedizin, Campus Mitte, Berlin, Germany
    Pharmacopsychiatry 40:64-7. 2007
    ..Because the pertinent models involve frontal and hippocampal glutamatergic projections, our goal was to investigate cerebral glutamate concentrations in healthy subjects with different smoking behavior...