Christian Freise

Summary

Affiliation: Humboldt University
Country: Germany

Publications

  1. doi request reprint The inhibitor of Ca(2+)-dependent K+ channels TRAM-34 blocks growth of hepatocellular carcinoma cells via downregulation of estrogen receptor alpha mRNA and nuclear factor-kappaB
    Christian Freise
    Department of Gastroenterology, Infectiology and Rheumatology, Campus Benjamin Franklin, Charite Universitatsmedizin Berlin, Hindenburgdamm 30, 12203 Berlin, Germany
    Invest New Drugs 31:452-7. 2013
  2. doi request reprint (+)-Episesamin inhibits adipogenesis and exerts anti-inflammatory effects in 3T3-L1 (pre)adipocytes by sustained Wnt signaling, down-regulation of PPARĪ³ and induction of iNOS
    Christian Freise
    Department of Gastroenterology, Infectiology and Rheumatology, Campus Benjamin Franklin, Charite Universitatsmedizin Berlin, Berlin, Germany
    J Nutr Biochem 24:550-5. 2013
  3. pmc A hepatoprotective Lindera obtusiloba extract suppresses growth and attenuates insulin like growth factor-1 receptor signaling and NF-kappaB activity in human liver cancer cell lines
    Christian Freise
    Department of Gastroenterology, Infectiology and Rheumatology, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12203 Berlin, Germany
    BMC Complement Altern Med 11:39. 2011
  4. doi request reprint (+)-Episesamin exerts anti-neoplastic effects in human hepatocellular carcinoma cell lines via suppression of nuclear factor-kappa B and inhibition of MMP-9
    Christian Freise
    Department of Gastroenterology, Infectiology and Rheumatology, Charite Campus Benjamin Franklin, Hindenburgdamm 30, 12203, Berlin, Germany
    Invest New Drugs 30:2087-95. 2012
  5. doi request reprint An active extract of Lindera obtusiloba inhibits adipogenesis via sustained Wnt signaling and exerts anti-inflammatory effects in the 3T3-L1 preadipocytes
    Christian Freise
    Department of Gastroenterology, Infectiology and Rheumatology, Campus Benjamin Franklin, Charite Universitatsmedizin Berlin, 12200 Berlin, Germany
    J Nutr Biochem 21:1170-7. 2010
  6. pmc Hydroxyproline-containing collagen analogs trigger the release and activation of collagen-sequestered proMMP-2 by competition with prodomain-derived peptide P33-42
    Martin Ruehl
    Department of Gastroenterology and Hepatology, Charite, Campus Benjamin Franklin, Hindenburgdamm 30, D 12200 Berlin, Germany
    Fibrogenesis Tissue Repair 4:1. 2011
  7. doi request reprint The alpha 2 chain of collagen type VI sequesters latent proforms of matrix-metalloproteinases and modulates their activation and activity
    Christian Freise
    Department of Gastroenterology and Hepatology, Charite, Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, Germany
    Matrix Biol 28:480-9. 2009

Collaborators

Detail Information

Publications7

  1. doi request reprint The inhibitor of Ca(2+)-dependent K+ channels TRAM-34 blocks growth of hepatocellular carcinoma cells via downregulation of estrogen receptor alpha mRNA and nuclear factor-kappaB
    Christian Freise
    Department of Gastroenterology, Infectiology and Rheumatology, Campus Benjamin Franklin, Charite Universitatsmedizin Berlin, Hindenburgdamm 30, 12203 Berlin, Germany
    Invest New Drugs 31:452-7. 2013
    ..Therefore, TRAM-34 might represent a novel therapeutic target for the treatment of HCC...
  2. doi request reprint (+)-Episesamin inhibits adipogenesis and exerts anti-inflammatory effects in 3T3-L1 (pre)adipocytes by sustained Wnt signaling, down-regulation of PPARĪ³ and induction of iNOS
    Christian Freise
    Department of Gastroenterology, Infectiology and Rheumatology, Campus Benjamin Franklin, Charite Universitatsmedizin Berlin, Berlin, Germany
    J Nutr Biochem 24:550-5. 2013
    ..In conclusion, (+)-episesamin seems to be the active drug in the L. obtusiloba extract being responsible for the inhibition of adipogenesis and, thus, should be evaluated as a novel potential complementary treatment for obesity...
  3. pmc A hepatoprotective Lindera obtusiloba extract suppresses growth and attenuates insulin like growth factor-1 receptor signaling and NF-kappaB activity in human liver cancer cell lines
    Christian Freise
    Department of Gastroenterology, Infectiology and Rheumatology, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12203 Berlin, Germany
    BMC Complement Altern Med 11:39. 2011
    ..obtusiloba extract in hepatic stellate cells. Thus, we here consequently examine anti-neoplastic effects of L.obtusiloba extract on human hepatocellular carcinoma (HCC) cell lines and the signaling pathways involved...
  4. doi request reprint (+)-Episesamin exerts anti-neoplastic effects in human hepatocellular carcinoma cell lines via suppression of nuclear factor-kappa B and inhibition of MMP-9
    Christian Freise
    Department of Gastroenterology, Infectiology and Rheumatology, Charite Campus Benjamin Franklin, Hindenburgdamm 30, 12203, Berlin, Germany
    Invest New Drugs 30:2087-95. 2012
    ..We conclude that (+)-episesamin has the potential to be further explored as a complementary treatment for HCC...
  5. doi request reprint An active extract of Lindera obtusiloba inhibits adipogenesis via sustained Wnt signaling and exerts anti-inflammatory effects in the 3T3-L1 preadipocytes
    Christian Freise
    Department of Gastroenterology, Infectiology and Rheumatology, Campus Benjamin Franklin, Charite Universitatsmedizin Berlin, 12200 Berlin, Germany
    J Nutr Biochem 21:1170-7. 2010
    ..In conclusion, extracts of L. obtusiloba should be evaluated as a potential complementary treatment option for obesity associated with the metabolic syndrome...
  6. pmc Hydroxyproline-containing collagen analogs trigger the release and activation of collagen-sequestered proMMP-2 by competition with prodomain-derived peptide P33-42
    Martin Ruehl
    Department of Gastroenterology and Hepatology, Charite, Campus Benjamin Franklin, Hindenburgdamm 30, D 12200 Berlin, Germany
    Fibrogenesis Tissue Repair 4:1. 2011
    ..abstract:..
  7. doi request reprint The alpha 2 chain of collagen type VI sequesters latent proforms of matrix-metalloproteinases and modulates their activation and activity
    Christian Freise
    Department of Gastroenterology and Hepatology, Charite, Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, Germany
    Matrix Biol 28:480-9. 2009
    ..Therefore, CVI and especially its alpha2(VI) chain might serve as a lead structure for MMP-based therapeutics which modulates the action of these matrix components, e.g. in fibrosis and cancer...