Agnes Floel

Summary

Affiliation: Humboldt University
Country: Germany

Publications

  1. pmc Reperfusion does not improve impaired rapid-onset cortical plasticity in patients with severe stenosis of the internal carotid artery
    Jonathan List
    Department of Neurology, Charite Universitatsmedizin Berlin, Berlin, Germany
    PLoS ONE 7:e41004. 2012
  2. pmc COMT Val158Met Polymorphism Modulates Cognitive Effects of Dietary Intervention
    Anja Veronica Witte
    Department of Neurology, Charité Universitätsmedizin Berlin Berlin, Germany
    Front Aging Neurosci 2:146. 2010
  3. pmc Physical fitness training in Subacute Stroke (PHYS-STROKE) - study protocol for a randomised controlled trial
    Agnes Floel
    Center for Stroke Research Berlin, Charite Universitatsmedizin Berlin, Berlin, Germany
    Trials 15:45. 2014
  4. doi request reprint tDCS-enhanced motor and cognitive function in neurological diseases
    Agnes Floel
    Department of Neurology, Center for Stroke Research, and NeuroCure Cluster of Excellence, Charite University Medicine, Germany Electronic address
    Neuroimage 85:934-47. 2014
  5. doi request reprint Non-invasive brain stimulation improves object-location learning in the elderly
    Agnes Floel
    Department of Neurology, Charite Universitatsmedizin Berlin, Berlin, Germany
    Neurobiol Aging 33:1682-9. 2012
  6. doi request reprint Physical activity and memory functions: are neurotrophins and cerebral gray matter volume the missing link?
    A Floel
    Department of Neurology, University of Muenster, Muenster, Germany
    Neuroimage 49:2756-63. 2010
  7. doi request reprint Short-term anomia training and electrical brain stimulation
    Agnes Floel
    Charite Universitatsmedizin, Department of Neurology, Center for Stroke Research Berlin and Cluster of Excellence NeuroCure, Chariteplatz 1, 10117 Berlin, Germany
    Stroke 42:2065-7. 2011
  8. pmc Granulocyte-colony stimulating factor (G-CSF) in stroke patients with concomitant vascular disease--a randomized controlled trial
    Agnes Floel
    Department of Neurology, Charite Universitatsmedizin Berlin, Berlin, Germany
    PLoS ONE 6:e19767. 2011
  9. pmc Imaging short- and long-term training success in chronic aphasia
    Ricarda Menke
    Department of Neurology, University of Munster, Munster, Germany
    BMC Neurosci 10:118. 2009
  10. doi request reprint Integrity of the hippocampus and surrounding white matter is correlated with language training success in aphasia
    Marcus Meinzer
    University of Munster, Department of Neurology, Munster, Germany
    Neuroimage 53:283-90. 2010

Detail Information

Publications49

  1. pmc Reperfusion does not improve impaired rapid-onset cortical plasticity in patients with severe stenosis of the internal carotid artery
    Jonathan List
    Department of Neurology, Charite Universitatsmedizin Berlin, Berlin, Germany
    PLoS ONE 7:e41004. 2012
    ..Carotid endarterectomy (CEA) in patients with severe ICA stenosis reduces stroke risk, but the impact on cognition or physiology of the respective hemisphere remains controversial...
  2. pmc COMT Val158Met Polymorphism Modulates Cognitive Effects of Dietary Intervention
    Anja Veronica Witte
    Department of Neurology, Charité Universitätsmedizin Berlin Berlin, Germany
    Front Aging Neurosci 2:146. 2010
    ..This might help to develop individualized therapies in future research based on genetic background...
  3. pmc Physical fitness training in Subacute Stroke (PHYS-STROKE) - study protocol for a randomised controlled trial
    Agnes Floel
    Center for Stroke Research Berlin, Charite Universitatsmedizin Berlin, Berlin, Germany
    Trials 15:45. 2014
    ..We will gather secondary functional outcomes as well as mechanistic parameters in an exploratory approach...
  4. doi request reprint tDCS-enhanced motor and cognitive function in neurological diseases
    Agnes Floel
    Department of Neurology, Center for Stroke Research, and NeuroCure Cluster of Excellence, Charite University Medicine, Germany Electronic address
    Neuroimage 85:934-47. 2014
    ..Its use in reducing disease-specific symptoms like dystonia or epileptic seizures is still unclear. ..
  5. doi request reprint Non-invasive brain stimulation improves object-location learning in the elderly
    Agnes Floel
    Department of Neurology, Charite Universitatsmedizin Berlin, Berlin, Germany
    Neurobiol Aging 33:1682-9. 2012
    ..In conclusion, retention of object-location learning in the elderly may be modulated by noninvasive brain stimulation, a finding of potential relevance not only for normal aging but also for memory deficits in pathological aging...
  6. doi request reprint Physical activity and memory functions: are neurotrophins and cerebral gray matter volume the missing link?
    A Floel
    Department of Neurology, University of Muenster, Muenster, Germany
    Neuroimage 49:2756-63. 2010
    ..While mediating factors will need to be further elucidated, these findings indicate that even low-level physical activity exerts beneficial effects on memory functions in older individuals...
  7. doi request reprint Short-term anomia training and electrical brain stimulation
    Agnes Floel
    Charite Universitatsmedizin, Department of Neurology, Center for Stroke Research Berlin and Cluster of Excellence NeuroCure, Chariteplatz 1, 10117 Berlin, Germany
    Stroke 42:2065-7. 2011
    ..Language training success in chronic aphasia remains only moderate. Electric brain stimulation may be a viable way to enhance treatment efficacy...
  8. pmc Granulocyte-colony stimulating factor (G-CSF) in stroke patients with concomitant vascular disease--a randomized controlled trial
    Agnes Floel
    Department of Neurology, Charite Universitatsmedizin Berlin, Berlin, Germany
    PLoS ONE 6:e19767. 2011
    ..G-CSF has been shown in animal models of stroke to promote functional and structural regeneration of the central nervous system. It thus might present a therapy to promote recovery in the chronic stage after stroke...
  9. pmc Imaging short- and long-term training success in chronic aphasia
    Ricarda Menke
    Department of Neurology, University of Munster, Munster, Germany
    BMC Neurosci 10:118. 2009
    ..In the present study, we show with functional magnetic resonance imaging (fMRI), that different brain regions may be involved in immediate versus long-term success of intensive language training in chronic post-stroke aphasia patients...
  10. doi request reprint Integrity of the hippocampus and surrounding white matter is correlated with language training success in aphasia
    Marcus Meinzer
    University of Munster, Department of Neurology, Munster, Germany
    Neuroimage 53:283-90. 2010
    ..Our results suggest that intensive language therapy success in chronic aphasia after MCA stroke is critically dependent on damage to the hippocampus and its surrounding structures...
  11. doi request reprint Enhanced rapid-onset cortical plasticity in CADASIL as a possible mechanism of preserved cognition
    Jonathan List
    Department of Neurology, University Hospital of Munster, 48149 Munster, Germany
    Cereb Cortex 21:2774-87. 2011
    ..ctDCS revealed no evidence of cortical dysplasticity. We conclude that increased rapid-onset cortical plasticity may contribute to largely preserved cognitive and motor function despite extensive ischemic SVD...
  12. doi request reprint Cortical plasticity is preserved in nondemented older individuals with severe ischemic small vessel disease
    Jonathan List
    Department of Neurology, University Hospital of Munster, Chariteplatz 1, Munster, Germany
    Hum Brain Mapp 34:1464-76. 2013
    ..Enhanced cortical plasticity in subjects with lower white matter integrity in memory-relevant areas might thus indicate a compensatory mechanism to counteract memory decline in severe SVD...
  13. doi request reprint Levodopa improves procedural motor learning in chronic stroke patients
    Nina Rösser
    Department of Neurology, University of Munster, Munster, Germany
    Arch Phys Med Rehabil 89:1633-41. 2008
    ....
  14. doi request reprint Interaction of BDNF and COMT polymorphisms on paired-associative stimulation-induced cortical plasticity
    A Veronica Witte
    Department of Neurology, Charite Universitatsmedizin Berlin, 10117 Berlin, Germany
    J Neurosci 32:4553-61. 2012
    ..Moreover, they show that genotype-related differences in neurophysiology translate into behavioral differences. These findings might contribute to a better understanding of the mechanisms of interindividual differences in cognition...
  15. ncbi request reprint High impact running improves learning
    Bernward Winter
    Department of Neurology, University of Muenster, Muenster, Germany
    Neurobiol Learn Mem 87:597-609. 2007
    ..Thus, BDNF and two of the catecholamines seem to be mediators by which physical exercise improves learning...
  16. doi request reprint Lack of improvement in odor identification by levodopa in humans
    Nina Rösser
    Department of Neurology, University of Muenster, Munster, Germany
    Physiol Behav 93:1024-9. 2008
    ..These hypotheses have to be tested in future experiments, but our study demonstrates that results from animal studies cannot be directly transferred to the human situation...
  17. doi request reprint Grammar learning in older adults is linked to white matter microstructure and functional connectivity
    Daria Antonenko
    Department of Neurology, NeuroCure Cluster of Excellence, and Center for Stroke Research Berlin, Charite Universitatsmedizin Berlin, Berlin, Germany
    Neuroimage 62:1667-74. 2012
    ....
  18. ncbi request reprint Dominance for language and spatial processing: limited capacity of a single hemisphere
    Andreas Jansen
    Department of Neurology, University of Munster, Munster, Germany
    Neuroreport 16:1017-21. 2005
    ..These findings suggest that hemispheric specializations for language and spatial functions interfere to some extent and favour additional recruitment of the opposite hemispheres for spatial functions...
  19. ncbi request reprint A shift of paradigm: from noradrenergic to dopaminergic modulation of learning?
    Caterina Breitenstein
    Department of Neurology, University of Muenster, Germany IZKF Münster, University of Muenster, Germany
    J Neurol Sci 248:42-7. 2006
    ..Both d-amphetamine and levodopa are thus potent drugs in enhancing learning in humans. We here discuss why the efficiency of both d-amphetamine and levodopa may be related to dopaminergic rather than noradrenergic actions...
  20. doi request reprint Noninvasive brain stimulation improves language learning
    Agnes Floel
    Department of Neurology, University of Munster, Munster, Germany
    J Cogn Neurosci 20:1415-22. 2008
    ..Our results demonstrate that anodal tDCS is a promising technique to enhance language learning in healthy adults and may also have the potential to improve language reacquisition after stroke...
  21. ncbi request reprint Crossed cerebro-cerebellar language dominance
    Andreas Jansen
    Department of Neurology, University of Munster, Munster, Germany
    Hum Brain Mapp 24:165-72. 2005
    ..The functional significance of the reported activations can now be tested in patients with lesions of the lateral posterior cerebellum...
  22. pmc G-CSF prevents the progression of structural disintegration of white matter tracts in amyotrophic lateral sclerosis: a pilot trial
    Thomas Duning
    Department of Neurology, University Hospital Muenster, Muenster, Germany
    PLoS ONE 6:e17770. 2011
    ..It therefore appears as an attractive and feasible drug candidate for the treatment of amyotrophic lateral sclerosis (ALS). The current pilot study was performed to determine whether treatment with G-CSF in ALS patients is feasible...
  23. doi request reprint Higher glucose levels associated with lower memory and reduced hippocampal microstructure
    Lucia Kerti
    From the Departments of Neurology L K, A V W, A W, A F and Biostatistics and Clinical Epidemiology U G, NeuroCure Cluster of Excellence A V W, A F, and Center for Stroke Research Berlin U G, A F, Charite University Medicine, Berlin and Department of Psychiatry D R, University of Halle, Germany
    Neurology 81:1746-52. 2013
    ....
  24. doi request reprint Anodal transcranial direct current stimulation temporarily reverses age-associated cognitive decline and functional brain activity changes
    Marcus Meinzer
    Department of Neurology, Charite University Medicine, 10117 Berlin, Germany
    J Neurosci 33:12470-8. 2013
    ..These findings may translate into novel treatments to ameliorate cognitive decline in normal aging in the future. ..
  25. doi request reprint Levodopa improves skilled hand functions in the elderly
    Agnes Floel
    Department of Neurology, University of Munster, Albert Schweitzer Strasse 33, 48129 Munster, Germany
    Eur J Neurosci 27:1301-7. 2008
    ..These results demonstrate that increasing the dopaminergic drive pharmacologically may be helpful when the motor system is challenged in the ageing process...
  26. doi request reprint Age affects chunk-based, but not rule-based learning in artificial grammar acquisition
    Julia Kürten
    Department of Neurology, University of Munster, Munster, Germany
    Neurobiol Aging 33:1311-7. 2012
    ..Our findings may explain divergent results on implicit learning tasks in previous studies on aging. They may also help to better understand compensatory mechanisms during the aging process...
  27. doi request reprint Lifestyle and memory in the elderly
    Agnes Floel
    Department of Neurology, University of Munster, Munster, Germany
    Neuroepidemiology 31:39-47. 2008
    ..This study aims to analyze the association between a composite lifestyle index and memory performance...
  28. ncbi request reprint Relationship between excitability, plasticity and thickness of the motor cortex in older adults
    Jonathan List
    Department of Neurology, Charite University Hospital, Berlin, Germany Center for Stroke Research Berlin, Charite Universitatsmedizin Berlin, Berlin, Germany
    Neuroimage 83:809-16. 2013
    ..Cortical excitability may thus be a parameter to identify individuals at risk for cognitive decline and gray matter atrophy, a hypothesis to be explored in future longitudinal studies...
  29. doi request reprint Differential effects of dual and unihemispheric motor cortex stimulation in older adults
    Robert Lindenberg
    Department of Neurology, NeuroCure Cluster of Excellence, and Center for Stroke Research Berlin, Charite University Medicine, 10117 Berlin, Germany
    J Neurosci 33:9176-83. 2013
    ....
  30. pmc Facilitating skilled right hand motor function in older subjects by anodal polarization over the left primary motor cortex
    Friedhelm C Hummel
    Brain Imaging and Neurostimulation BINS Laboratory, Department of Neurology, University Medical Center Hamburg Eppendorf, Martinistr 52, 20246 Hamburg, Germany
    Neurobiol Aging 31:2160-8. 2010
    ..We conclude that anodal tDCS applied over M1 can facilitate performance of skilled hand functions required for activities of daily living in older subjects...
  31. ncbi request reprint Tonic dopaminergic stimulation impairs associative learning in healthy subjects
    Caterina Breitenstein
    Department of Neurology, University of Muenster, Muenster, Germany
    Neuropsychopharmacology 31:2552-64. 2006
    ..Thus, phasic signaling seems to be the critical mechanism by which dopamine enhances associative learning in healthy subjects and stroke patients...
  32. doi request reprint Recovery of function in humans: cortical stimulation and pharmacological treatments after stroke
    Agnes Floel
    Department of Neurology, University of Muenster, Germany
    Neurobiol Dis 37:243-51. 2010
    ..Subsequently, we expand on possibilities of adjuvant therapy in human rehabilitation using cortical stimulation and pharmacological treatments. Finally, we suggest future directions for research in this field...
  33. ncbi request reprint Determining the hemispheric dominance of spatial attention: a comparison between fTCD and fMRI
    Andreas Jansen
    Department of Neurology, University of Munster, D 4829 Münster, Germany
    Hum Brain Mapp 23:168-80. 2004
    ..Therefore, scanning large cohorts with fTCD for hemispheric dominance during Landmark task will provide results consistent with fMRI. FMRI can then be used for in depth assessment of the specific patterns of activation...
  34. ncbi request reprint Electrical brain stimulation improves cognitive performance by modulating functional connectivity and task-specific activation
    Marcus Meinzer
    Department of Neurology, Center for Stroke Research Berlin, and Cluster of Excellence NeuroCure, Charite Universitatsmedizin, Berlin 10117, Germany
    J Neurosci 32:1859-66. 2012
    ....
  35. doi request reprint Pain is associated with regional grey matter reduction in the general population
    Ruth Ruscheweyh
    Department of Neurology, University of Munster, Munster, Germany
    Pain 152:904-11. 2011
    ..The lack of morphometric anomalies in subjects with past pain supports recent evidence suggesting that pain-related grey matter changes are reversible after cessation of pain...
  36. doi request reprint Walking the talk--speech activates the leg motor cortex
    Gianpiero Liuzzi
    Department of Neurology, University of Munster, Germany
    Neuropsychologia 46:2824-30. 2008
    ..In the frame of the motor theory of speech this finding suggests that the system of gestural communication, from which speech may have evolved, is not confined to the hand but includes gestural movements of other body parts as well...
  37. pmc Biomarkers and perfusion--training-induced changes after stroke (BAPTISe): protocol of an observational study accompanying a randomized controlled trial
    Alexander H Nave
    Center for Stroke Research Berlin CSB, Charite Universitatsmedizin Berlin, Chariteplatz 1, 10117 Berlin, Germany
    BMC Neurol 13:197. 2013
    ..Our exploratory study aims to investigate training-induced changes in blood biomarker levels and magnetic resonance imaging in patients with subacute ischemic stroke...
  38. doi request reprint Transcranial direct current stimulation over multiple days improves learning and maintenance of a novel vocabulary
    Marcus Meinzer
    Department of Neurology, Charite University Medicine, Berlin, Germany Center for Stroke Research, Charite University Medicine, Berlin, Germany Center for Clinical Research, University of Queensland, Brisbane, Australia Electronic address
    Cortex 50:137-47. 2014
    ..Studies assessing the impact of multiple stimulation sessions on learning that may induce long-lasting behavioural and neural changes are scarce and have not yet been accomplished in the language domain in healthy individuals...
  39. doi request reprint Magnetoencephalographic evidence for the modulation of cortical swallowing processing by transcranial direct current stimulation
    Sonja Suntrup
    Institute for Biomagnetism and Biosignal Analysis, University of Muenster, Malmedyweg 15, 48149 Muenster, Germany Department of Neurology, University of Muenster, Albert Schweitzer Campus 1, Gebäude A1, 48149 Munster, Germany Electronic address
    Neuroimage 83:346-54. 2013
    ..These neuroplastic effects were associated with subtle behavioral gains during complex swallow tasks in healthy individuals suggesting that tDCS deserves further evaluation as a treatment tool for dysphagia...
  40. pmc The influence of spatial registration on detection of cerebral asymmetries using voxel-based statistics of fractional anisotropy images and TBSS
    Siawoosh Mohammadi
    Department of Neurology, University of Munster, Munster, Germany
    PLoS ONE 7:e36851. 2012
    ..Finally, we demonstrated that the "multi-contrast individual-hemisphere" approach showed the least residual spatial misregistrations and thus might be most appropriate for cerebral FA-VBS analyses...
  41. ncbi request reprint White matter integrity in the vicinity of Broca's area predicts grammar learning success
    Agnes Floel
    Department of Neurology, University of Munster, Munster, Germany
    Neuroimage 47:1974-81. 2009
    ..The relevance of these findings for acquisition of a natural language has to be established in future studies...
  42. ncbi request reprint Reproducibility of hemispheric blood flow increases during line bisectioning
    Agnes Floel
    Department of Neurology, University Hospital of Munster, University of Munster, Albert Schweitzer Strasse 33, Munster, Germany
    Clin Neurophysiol 113:917-24. 2002
    ..To determine if attention-related changes of hemispheric perfusion increases, as assessed by blood-flow sensitive techniques, are as reliable as language-related hemispheric perfusion increases...
  43. ncbi request reprint Levodopa: faster and better word learning in normal humans
    Stefan Knecht
    Department of Neurology, University of Munster, Albert Schweitzer Strasse 33, D 48129 Munster, Germany
    Ann Neurol 56:20-6. 2004
    ..These findings indicate new ways to potentiate learning in a variety of domains if conventional training alone fails...
  44. pmc Cortical swallowing processing in early subacute stroke
    Inga K Teismann
    Department of Neurology, University of Muenster, Albert Schweitzer Str, 33, 48149 Muenster, Germany
    BMC Neurol 11:34. 2011
    ..The aim of the present study was to determine the different patterns of cortical swallowing processing in patients with hemispheric and brainstem stroke with and without dysphagia in the early subacute phase...
  45. doi request reprint Functional and structural syntax networks in aging
    Daria Antonenko
    Department of Neurology, NeuroCure Cluster of Excellence, and Center for Stroke Research Berlin, Charite Universitatsmedizin Berlin, Germany Electronic address
    Neuroimage 83:513-23. 2013
    ....
  46. doi request reprint Effects of COMT polymorphisms on brain function and behavior in health and disease
    A Veronica Witte
    Department of Neurology, Charite University Berlin, Chariteplatz 1, 10117 Berlin, Germany
    Brain Res Bull 88:418-28. 2012
    ..Future studies should try to disentangle the complex effects of COMT Val158Met on brain functions by taking gender, age, ethnicity, endophenotypes, as well as gene-environment and gene-gene interactions into account...
  47. ncbi request reprint Cortical reorganization due to impaired cerebral autoregulation in individuals with occlusive processes of the internal carotid artery
    Jonathan List
    Department of Neurology, Charite University Hospital, Berlin, Germany Center for Stroke Research Berlin, Charite Universitatsmedizin Berlin, Germany Electronic address
    Brain Stimul 7:381-7. 2014
    ..To study the impact of impaired cerebral autoregulation on cortical neurophysiology, long term potentiation (LTP)-like plasticity, motor learning and brain structure...
  48. doi request reprint Healthy aging by staying selectively connected: a mini-review
    Daria Antonenko
    Department of Neurology, NeuroCure Cluster of Excellence, and Center for Stroke Research Berlin, Charite Universitatsmedizin Berlin, Berlin, Germany
    Gerontology 60:3-9. 2014
    ..In this review, we outline the network perspective on healthy brain aging and discuss recent developments in this field...
  49. ncbi request reprint Therapy of Sneddon syndrome
    Agnes Floel
    Department of Neurology, University of Munster, Munster, Germany
    Eur Neurol 48:126-32. 2002
    ..Therapeutic options in SNS in both aPL-positive and aPL-negative patients with SNS are discussed...