Lars Fischer

Summary

Affiliation: Humboldt University
Country: Germany

Publications

  1. doi request reprint Meningeal dissemination in primary CNS lymphoma: prospective evaluation of 282 patients
    L Fischer
    Department of Hematology, Oncology and Transfusion Medicine, Charite Campus Benjamin Franklin, Berlin, Germany
    Neurology 71:1102-8. 2008
  2. ncbi request reprint Skewed expression of natural-killer (NK)-associated antigens on lymphoproliferations of large granular lymphocytes (LGL)
    Lars Fischer
    Department of Hematology, Oncology and Transfusion Medicine, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Germany
    Hematol Oncol 24:78-85. 2006
  3. pmc CD56 expression in T-cell acute lymphoblastic leukemia is associated with non-thymic phenotype and resistance to induction therapy but no inferior survival after risk-adapted therapy
    Lars Fischer
    Charite Campus Benjamin Franklin, Medizinische Klinik III, Berlin
    Haematologica 94:224-9. 2009
  4. doi request reprint CXCL13 and CXCL12 in central nervous system lymphoma patients
    Lars Fischer
    Medical Clinic for Hematology and Oncology, Charite Campus Benjamin Franklin, Berlin, Germany
    Clin Cancer Res 15:5968-73. 2009
  5. ncbi request reprint Prospective trial on topotecan salvage therapy in primary CNS lymphoma
    L Fischer
    Department of Haematology, Oncology and Transfusion Medicine, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Germany
    Ann Oncol 17:1141-5. 2006
  6. doi request reprint Systemic high-dose methotrexate plus ifosfamide is highly effective for central nervous system (CNS) involvement of lymphoma
    Lars Fischer
    Department of Hematology, Oncology and Transfusion Medicine, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany
    Ann Hematol 88:133-9. 2009
  7. pmc Differential micro-RNA expression in primary CNS and nodal diffuse large B-cell lymphomas
    Lars Fischer
    Department of Hematology and Oncology, Charite Universitatsmedizin, Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, Germany
    Neuro Oncol 13:1090-8. 2011
  8. doi request reprint Non-enhancing relapse of a primary CNS lymphoma with multiple diffusion-restricted lesions
    Lars Fischer
    Department of Hematology and Oncology, Charite Universitatsmedizin, Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, Germany
    J Neurooncol 102:163-6. 2011
  9. doi request reprint Primary central nervous system lymphoma: monocenter, long-term, intent-to-treat analysis
    Philipp Kiewe
    Department of Hematology, Oncology, and Transfusion Medicine, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany
    Cancer 112:1812-20. 2008
  10. ncbi request reprint Relapse of primary central nervous system lymphoma: clinical features, outcome and prognostic factors
    Kristoph Jahnke
    Department of Hematology, Oncology and Transfusion Medicine, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, D 12200, Berlin, Germany
    J Neurooncol 80:159-65. 2006

Collaborators

Detail Information

Publications38

  1. doi request reprint Meningeal dissemination in primary CNS lymphoma: prospective evaluation of 282 patients
    L Fischer
    Department of Hematology, Oncology and Transfusion Medicine, Charite Campus Benjamin Franklin, Berlin, Germany
    Neurology 71:1102-8. 2008
    ..We prospectively evaluated the diagnostic value of PCR in comparison with CSF cytomorphology and MRI for diagnosing meningeal dissemination in PCNSL...
  2. ncbi request reprint Skewed expression of natural-killer (NK)-associated antigens on lymphoproliferations of large granular lymphocytes (LGL)
    Lars Fischer
    Department of Hematology, Oncology and Transfusion Medicine, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Germany
    Hematol Oncol 24:78-85. 2006
    ..We consistently found a skewed expression pattern of novel NK markers as a pathological feature of LGLL. These antigens should be included in the diagnostic workup of this rare disease...
  3. pmc CD56 expression in T-cell acute lymphoblastic leukemia is associated with non-thymic phenotype and resistance to induction therapy but no inferior survival after risk-adapted therapy
    Lars Fischer
    Charite Campus Benjamin Franklin, Medizinische Klinik III, Berlin
    Haematologica 94:224-9. 2009
    ..Expression of CD56 has been associated with poor prognosis in acute myeloid leukemia and aggressive lymphoma...
  4. doi request reprint CXCL13 and CXCL12 in central nervous system lymphoma patients
    Lars Fischer
    Medical Clinic for Hematology and Oncology, Charite Campus Benjamin Franklin, Berlin, Germany
    Clin Cancer Res 15:5968-73. 2009
    ..In this study, we evaluated the chemokines CXCL12 and CXCL13 in the cerebrospinal fluid (CSF) and serum of patients with CNS lymphoma...
  5. ncbi request reprint Prospective trial on topotecan salvage therapy in primary CNS lymphoma
    L Fischer
    Department of Haematology, Oncology and Transfusion Medicine, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Germany
    Ann Oncol 17:1141-5. 2006
    ..Standard salvage therapy has not been established for recurrent primary central nervous system lymphoma (PCNSL). We report the final results of a prospective study on topotecan chemotherapy in relapsed or refractory PCNSL...
  6. doi request reprint Systemic high-dose methotrexate plus ifosfamide is highly effective for central nervous system (CNS) involvement of lymphoma
    Lars Fischer
    Department of Hematology, Oncology and Transfusion Medicine, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany
    Ann Hematol 88:133-9. 2009
    ..The median overall survival was not reached. Systemic chemotherapy with HDMTX/IFO is a feasible and promising treatment modality for CNS relapse of a malignant lymphoma...
  7. pmc Differential micro-RNA expression in primary CNS and nodal diffuse large B-cell lymphomas
    Lars Fischer
    Department of Hematology and Oncology, Charite Universitatsmedizin, Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, Germany
    Neuro Oncol 13:1090-8. 2011
    ..We conclude that PCNSL exhibits a distinct pattern of miRNA expression compared with nDLBCL. This argues for the involvement of different molecular mechanisms in the pathogenesis of these two lymphoma types...
  8. doi request reprint Non-enhancing relapse of a primary CNS lymphoma with multiple diffusion-restricted lesions
    Lars Fischer
    Department of Hematology and Oncology, Charite Universitatsmedizin, Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, Germany
    J Neurooncol 102:163-6. 2011
    ..Relapse of his PCNSL was secured histologically only on autopsy. The possible etiology of the diffusion-restricted lesions is discussed...
  9. doi request reprint Primary central nervous system lymphoma: monocenter, long-term, intent-to-treat analysis
    Philipp Kiewe
    Department of Hematology, Oncology, and Transfusion Medicine, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany
    Cancer 112:1812-20. 2008
    ..This retrospective, single-center study assessed the feasibility, outcome, and late side effects of the treatment of immunocompetent patients with primary central nervous system lymphoma (PCNSL) at the authors' institution...
  10. ncbi request reprint Relapse of primary central nervous system lymphoma: clinical features, outcome and prognostic factors
    Kristoph Jahnke
    Department of Hematology, Oncology and Transfusion Medicine, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, D 12200, Berlin, Germany
    J Neurooncol 80:159-65. 2006
    ..Survival of patients with relapsed PCNSL is poor despite high response rates to salvage therapy. Good KPS, isolated systemic relapse and treatment for relapse were significantly associated with longer survival...
  11. pmc Meningeal dissemination in primary CNS lymphoma: diagnosis, treatment, and survival in a large monocenter cohort
    Philipp Kiewe
    Department of Hematology, Oncology and Transfusion Medicine, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30 31, 12200 Berlin, Germany
    Neuro Oncol 12:409-17. 2010
    ..No impact on outcome was seen for MD, diagnosed by any of the methods used; however, patients with cytomorphologic proof of MD had a significantly shorter median EFS and OAS...
  12. doi request reprint High-dose methotrexate with or without whole brain radiotherapy for primary CNS lymphoma (G-PCNSL-SG-1): a phase 3, randomised, non-inferiority trial
    Eckhard Thiel
    Department of Hematology and Oncology, Charite Berlin, Berlin, Germany
    Lancet Oncol 11:1036-47. 2010
    ..We aimed to investigate whether first-line chemotherapy based on high-dose methotrexate was non-inferior to the same chemotherapy regimen followed by whole brain radiotherapy for overall survival...
  13. ncbi request reprint The type of ATG matters -- natural killer cells are influenced differentially by Thymoglobulin, Lymphoglobulin and ATG-Fresenius
    Olaf Penack
    Department of Hematology, Oncology, and Transfusion Medicine, Charite Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, Germany
    Transpl Immunol 18:85-7. 2007
    ..Randomized trials addressing the impact of different ATGs on lymphocyte subpopulations in the clinical setting are urgently warranted...
  14. doi request reprint Ifosfamide or trofosfamide in patients with intraocular lymphoma
    Kristoph Jahnke
    Department of Hematology and Oncology, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Germany
    J Neurooncol 93:213-7. 2009
    ..IFO or TRO were active and well tolerated in this study. Thus, they may represent suitable combination partners for other cytostatics used for PCNSL and IOL treatment...
  15. doi request reprint Expression of interleukin 15 in primary adult acute lymphoblastic leukemia
    Shuling Wu
    Department of Hematology, Oncology and Transfusion Medicine, Campus Benjamin Franklin, Charity Medical Center, Hindenburgdamm 30, 12203 Berlin, Germany
    Cancer 116:387-92. 2010
    ..We determined the expression of IL-15 in lymphoblasts and evaluated its potential impact on the outcome in adult acute lymphoblastic leukemia (ALL)...
  16. ncbi request reprint A novel method to quantify and characterize leukemia-reactive natural killer cells in patients undergoing allogeneic hematopoietic stem cell transplantation following conventional or reduced-dose conditioning
    Olaf Penack
    Department of Hematology, Charite, Campus Benjamin Franklin, Berlin, Germany
    Int J Hematol 85:326-32. 2007
    ..Using this method, we found that NK cells had high antitumor cytotoxic activity after nonmyeloablative conditioning, which may contribute to the effectiveness of nonmyeloablative conditioning...
  17. ncbi request reprint Glucarpidase (carboxypeptidase g2) intervention in adult and elderly cancer patients with renal dysfunction and delayed methotrexate elimination after high-dose methotrexate therapy
    Stefan Schwartz
    Medizinische Klinik III, Hämatologie, Onkologie und Transfusionsmedizin, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, Germany
    Oncologist 12:1299-308. 2007
    ..We evaluated the effects of glucarpidase intervention in adult and elderly patients with delayed MTX elimination...
  18. pmc Clinical features and prognostic implications of TCF3-PBX1 and ETV6-RUNX1 in adult acute lymphoblastic leukemia
    Thomas Burmeister
    Med Klinik für Hämatologie Onkologie Hindenburgdamm 30, 12200 Berlin, Germany
    Haematologica 95:241-6. 2010
    ..However, the prognostic impact of other rarer fusion genes is less well established in adult acute lymphoblastic leukemia than in the childhood form...
  19. ncbi request reprint Response to chemotherapy and treating institution predict survival in primary central nervous system lymphoma
    Agnieszka Korfel
    Department of Haematology, Oncology and Transfusion Medicine, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany
    Br J Haematol 128:177-83. 2005
    ..2 vs. 9.9 months, P = 0.02). Median survival was significantly longer at institutions accruing at least four patients than at those with fewer patients (31.5 vs. 9.5 months, P = 0.03)...
  20. ncbi request reprint Response of relapsed or refractory primary central nervous system lymphoma (PCNSL) to topotecan
    L Fischer
    Department of Hematology, Oncology, and Transfusion Medicine, Klinikum Benjamin Franklin, Freie Universitat Berlin, Germany
    Neurology 62:1885-7. 2004
    ..Four complete remissions and two partial remissions were achieved. Progression-free survival was 20% at 6 months and 13% at 12 months...
  21. ncbi request reprint The anti-lymphoma effect of antibody-mediated immunotherapy is based on an increased degranulation of peripheral blood natural killer (NK) cells
    Lars Fischer
    Department of Hematology, Oncology and Transfusion Medicine, Charite Campus Benjamin Franklin, Berlin, Germany
    Exp Hematol 34:753-9. 2006
    ..Due to methodical difficulties, little is yet known about the relevant cell subpopulations and effector mechanisms leading to tumor lysis in ADCC...
  22. ncbi request reprint Unusual sites of Hodgkin's lymphoma: CASE 3. Cholemic nephrosis in Hodgkin's lymphoma with liver involvement
    Philipp Kiewe
    Charite University Medicine, Campus Benjamin Franklin, Berlin, Germany
    J Clin Oncol 22:4230-1. 2004
  23. ncbi request reprint Isolated B-cell lymphoproliferative disorder at the dura mater with B-cell chronic lymphocytic leukemia immunophenotype
    Philipp Kiewe
    Department of Hematology, Oncology and Transfusion Medicine, Charite Campus Benjamin Franklin, Berlin, Germany
    Clin Lymphoma Myeloma 7:594-6. 2007
    ....
  24. ncbi request reprint Treatment of primary intraocular lymphoma with oral trofosfamide: report of two cases and review of the literature
    Kristoph Jahnke
    Department of Hematology, Oncology and Transfusion Medicine, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, Germany
    Graefes Arch Clin Exp Ophthalmol 242:771-6. 2004
    ..The prognosis of primary intraocular lymphoma (PIOL) is poor. Due to frequent ocular and/or CNS relapses, the optimal treatment for PIOL has not yet been defined. This is the first report of PIOL treatment with trofosfamide...
  25. ncbi request reprint Pharmacokinetics and efficacy of ifosfamide or trofosfamide in patients with intraocular lymphoma
    K Jahnke
    Department of Haematology, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany
    Ann Oncol 16:1974-8. 2005
    ..The prognosis of intraocular lymphoma (IOL) is poor, and the optimal treatment has not yet been defined. The study assesses ifosfamide (IFO) and trofosfamide (TRO) for treating IOL...
  26. ncbi request reprint CD56dimCD16neg cells are responsible for natural cytotoxicity against tumor targets
    O Penack
    Department of Hematology, Oncology, and Transfusion Medicine, Charite Campus Benjamin Franklin, Berlin, Germany
    Leukemia 19:835-40. 2005
    ..Our results indicate that the CD107a assay represents a promising new method for the quantification and characterization of cells exhibiting natural cytotoxicity...
  27. ncbi request reprint High-dose methotrexate toxicity in elderly patients with primary central nervous system lymphoma
    K Jahnke
    Department of Hematology, Oncology and Transfusion Medicine, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, Germany
    Ann Oncol 16:445-9. 2005
    ..We evaluated HDMTX-related toxicity with special regard to age distribution in patients with primary central nervous system lymphoma (PCNSL) in a phase IV multicenter trial...
  28. ncbi request reprint Testicular germ cell tumor with rhabdomyosarcoma successfully treated by disease-adapted chemotherapy including high-dose chemotherapy: case report and review of the literature
    A Korfel
    Department of Hematology, Oncology and Transfusion Medicine, Klinikum Benjamin Franklin, , Berlin, Germany
    Bone Marrow Transplant 28:787-9. 2001
    ..To date, remission has lasted for 4 years. Tumor-adapted CHT including HD-CHT with APBSCT can induce long term remissions in high-risk patients with transformed GCT. A review of the literature is given...
  29. ncbi request reprint A 19-year-old male with generalized seizures, unconsciousness and a deviation of gaze
    L Fischer
    Department of Hematology, Oncology and Transfusion Medicine, Klinikum Benjamin Franklin, Freie Universitat, Berlin, Germany
    Brain Pathol 16:185-6, 187. 2006
    ..We present the clinical, laboratory and radiological findings and discuss the pathogenesis of this unusual LCDD manifestation...
  30. pmc Phase II study of central nervous system (CNS)-directed chemotherapy including high-dose chemotherapy with autologous stem cell transplantation for CNS relapse of aggressive lymphomas
    Agnieszka Korfel
    Department of Hematology and Oncology, Charite Universitatsmedizin Berlin, Germany
    Haematologica 98:364-70. 2013
    ..The protocol assessed proved feasible and highly active with long-lasting remissions in a large proportion of patients. (ClinicalTrials.govIdentifier NCT01148173)...
  31. ncbi request reprint Expression of the human homologue of rat NG2 in adult acute lymphoblastic leukemia: close association with MLL rearrangement and a CD10(-)/CD24(-)/CD65s(+)/CD15(+) B-cell phenotype
    S Schwartz
    Medizinische Klinik III, Hämatologie, Onkologie und Transfusionsmedizin, Klinikum Benjamin Franklin, Freie Universitat, Berlin, Germany
    Leukemia 17:1589-95. 2003
    ..As NG2 is negative in non-malignant hematopoietic cells, this novel antigen might also serve in future studies as a powerful marker in monitoring minimal residual disease...
  32. ncbi request reprint Serotherapy with thymoglobulin and alemtuzumab differentially influences frequency and function of natural killer cells after allogeneic stem cell transplantation
    O Penack
    Department of Hematology, Oncology, and Transfusion Medicine, Charite, Berlin, Germany
    Bone Marrow Transplant 41:377-83. 2008
    ..Prolonged immunosuppression with increased risk of infections and tumor relapse are a potential threat to patients undergoing HCST and receiving alemtuzumab as T-cell depletion...
  33. ncbi request reprint Longitudinal analysis of Epstein-Barr viral load in plasma and peripheral blood mononuclear cells of transplanted patients by real-time polymerase chain reaction
    Hans Joachim Wagner
    Department of Pediatrics, Medical University of Lubeck
    Transplantation 74:656-64. 2002
    ....
  34. ncbi request reprint The segments of the hepatic veins-is there a spatial correlation to the Couinaud liver segments?
    Lars Fischer
    Department of Surgery, University of Heidelberg, Heidelberg, Germany
    Eur J Radiol 53:245-55. 2005
    ..To investigate and describe the volume, position and shape of venous segments within the human liver and define their spatial correlation to the Couinaud segments (CS) and to the portal vein segments (PVS)...
  35. ncbi request reprint Extracellular matrix stimulates reactive oxygen species production and increases pancreatic cancer cell survival through 5-lipoxygenase and NADPH oxidase
    Mouad Edderkaoui
    Department of Medicine, Veterans Affairs Greater Los Angeles Healthcare System, University of California Los Angeles, CA 90073, USA
    Am J Physiol Gastrointest Liver Physiol 289:G1137-47. 2005
    ..These mechanisms may play an important role in pancreatic cancer resistance to treatments and thus represent novel therapeutic targets...
  36. ncbi request reprint The diagnostic value of cerebrospinal fluid pleocytosis and protein in the detection of lymphomatous meningitis in primary central nervous system lymphomas
    Lars Fischer
    Haematologica 91:429-30. 2006
    ..Pleocytosis correlated with positive cytology, whereas CSF protein did not (specificity cell count vs. protein 74% vs. 34% [p<0.001], sensitivity 86% vs. 62% [p=0.18])...
  37. ncbi request reprint Limits of Couinaud's liver segment classification: a quantitative computer-based three-dimensional analysis
    Lars Fischer
    Department of Surgery, University of Heidelberg, INF Feld 110, 69120 Heidelberg, Germany
    J Comput Assist Tomogr 26:962-7. 2002
    ..As the position and shape of these segments are variable and their borders are hidden within the homogeneous liver mass, the accuracy of segment identification methods needs computer-aided reevaluation...
  38. pmc Effects of STI571 (gleevec) on pancreatic cancer cell growth
    Junsheng Li
    Department of General Surgery, University of Heidelberg, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany
    Mol Cancer 2:32. 2003
    ..STI571 has specific activity in inhibiting c-kit, PDGF and Abl receptor tyrosine kinases and has proven successful in the treatment of CML and GIST patients. Here, we investigated the potential role of STI571 in pancreatic cancer...