Research Topics
Genomes and Genes | Ursula Felderhoff-MueserSummaryAffiliation: Humboldt University Country: Germany Publications
| Collaborators
|
Detail Information
Publications
Oxygen causes cell death in the developing brainUrsula Felderhoff-Mueser
Department of Neonatology, Humboldt University Berlin, Charit, Campus Virchow Klinikum, 13353 Berlin, Germany
Neurobiol Dis 17:273-82. 2004..Our findings reveal a mechanism that could potentially damage the developing brain of human premature neonates...- Caspase-1-processed interleukins in hyperoxia-induced cell death in the developing brainUrsula Felderhoff-Mueser
Department of Neonatology, Charite, Campus Virchow Klinikum, Humboldt University Medical Center, Augustenburger Platz 1, D 13353 Berlin, Germany
Ann Neurol 57:50-9. 2005..These cytokines might serve as useful targets for therapeutic approaches aimed at preserving neuronal function in the immature brain, which is exquisitely sensitive to a variety of iatrogenic measures including oxygen... 
Elevated nerve growth factor and neurotrophin-3 levels in cerebrospinal fluid of children with hydrocephalusF Hochhaus
Neonatology, Charite, Campus Virchow Klinikum, Humboldt University, Berlin, Germany
BMC Pediatr 1:2. 2001..We investigated whether concentrations of NGF and NT-3 are increased in the CSF of children with hydrocephalus...
Increased cerebrospinal fluid concentrations of soluble Fas (CD95/Apo-1) in hydrocephalusU Felderhoff-Mueser
Department of Neonatology, Charite Children s Hospital, Virchow Klinikum, Humboldt University, Augustenburger Platz 1, 13353 Berlin, Germany
Arch Dis Child 84:369-72. 2001..One of the regulators of the apoptotic cell death programme is the receptor mediated Fas/Fas ligand interaction...- Intrauterine onset of acute neuropathic type 2 Gaucher disease: identification of a novel insertion sequenceUrsula Felderhoff-Mueser
Department of Neonatology, Charite, Campus Virchow Klinikum, Berlin, Germany
Am J Med Genet A 128:138-43. 2004..The transheterozygous combination of a mutation, previously described in type 1 Gaucher disease, together with a newly identified insertion may result in this severe phenotype... - Soluble Fas (CD95/Apo-1), soluble Fas ligand, and activated caspase 3 in the cerebrospinal fluid of infants with posthemorrhagic and nonhemorrhagic hydrocephalusUrsula Felderhoff-Mueser
Department of Neonatology, Charite, Children s Hospital, Campus Virchow Klinikum, D 13353 Berlin, Germany
Pediatr Res 54:659-64. 2003..Increased intrathecal release of sFas in the cerebrospinal fluid of infants with hydrocephalus may serve as an indicator of brain injury from progressive ventricular dilatation... - Severe spinal muscular atrophy variant associated with congenital bone fracturesUrsula Felderhoff-Mueser
Department of Neonatology, Humboldt University, Berlin, Germany
J Child Neurol 17:718-21. 2002..We present clinical, molecular, and autopsy findings of a newborn boy presenting with generalized muscular atrophy in combination with congenital bone fractures and extremely thin ribs but without contractures... - 31Phosphorus magnetic resonance spectroscopy in late-onset Tay-Sachs diseaseU Felderhoff-Mueser
Department of Neonatology, Charite Children s Hospital, Humboldt University, Berlin, Germany
J Child Neurol 16:377-80. 2001..The clinical findings were well related to the changes in spectroscopically determined metabolites... - Protection with estradiol in developmental models of apoptotic neurodegenerationStiliani Asimiadou
Neuroscience Research Center, Charit, Humboldt University Berlin, Berlin, Germany
Ann Neurol 58:266-76. 2005..Its supplementation may particularly help to improve neurocognitive outcome in preterm infants who are prematurely deprived of maternal estrogen... 
Erythropoietin protects the developing brain from hyperoxia-induced cell death and proteome changesAngela M Kaindl
Department of Pediatric Neurology, Charite Universitatsmedizin Berlin, Campus Virchow Klinikum, Berlin, Germany
Ann Neurol 64:523-34. 2008..Because a tissue-protective effect has been observed for recombinant erythropoietin (rEpo), widely used in neonatal medicine for its hematopoietic effect, we examined the effect of rEpo on hyperoxia-induced brain damage...- Activation of caspase-1 dependent interleukins in developmental brain traumaMarco Sifringer
Department of Pediatric Neurology, Children s Hospital, Medical Faculty Carl Gustav Carus, Technical University Dresden, 01307 Dresden, Germany
Neurobiol Dis 25:614-22. 2007..These findings indicate that IL-18 is involved in trauma-induced neuronal cell death in the immature rodent brain and might serve as a potential therapeutic target... - Estradiol attenuates hyperoxia-induced cell death in the developing white matterBettina Gerstner
Department of Neonatology, Charite Campus Virchow Klinikum, Berlin, Germany
Ann Neurol 61:562-73. 2007..Furthermore, neuroprotective properties have been attributed to estrogens. We examined the effect of E2 on hyperoxia-induced cell death in the developing white matter in the rat brain... - Fas (CD95/Apo-1)/Fas ligand expression in neonates with pontosubicular neuron necrosisFrank K H van Landeghem
Institute of Neuropathology, Charite, Campus Virchow Klinikum, Humboldt University, Augustenburger Platz 1, D 13353 Berlin, Germany
Pediatr Res 51:129-35. 2002..There was no significant difference between cases with and without PSN. We conclude that in the developing human brain, cells expressing the Fas receptor may be susceptible to undergoing apoptosis in response to hypoxic-ischemic injury... - Maturation-dependent oligodendrocyte apoptosis caused by hyperoxiaBettina Gerstner
Department of Neonatology, Charite Campus Virchow Klinikum, Berlin, Germany
J Neurosci Res 84:306-15. 2006..Hyperoxia triggers maturation-dependent apoptosis in immature and pre-OLs and involves caspase activation. This mechanism may be relevant to the white matter injury observed in infants born preterm... - Erythropoietin attenuates hyperoxia-induced oxidative stress in the developing rat brainMarco Sifringer
Department of Neonatology, Charite Universitatsmedizin Berlin, Berlin, Germany
Brain Behav Immun 24:792-9. 2010..Our results suggest that rEpo generates its protective effect against oxygen toxicity by a reduction of diverse oxidative stress parameters and by limiting the stressor-inducible changes in both HO-1 and cholinergic functions... - Erythropoietin attenuates hyperoxia-induced cell death by modulation of inflammatory mediators and matrix metalloproteinasesMarco Sifringer
Department of Neonatology, Campus Virchow Klinikum, Charite Universitatsmedizin Berlin, Berlin, Germany
Dev Neurosci 31:394-402. 2009..Our results suggest that rEpo generates its protective effect against oxygen toxicity through a reduction of proinflammatory mediator levels... - A critical role for Fas/CD-95 dependent signaling pathways in the pathogenesis of hyperoxia-induced brain injuryMark Dzietko
Department of Neonatology, Charite, Universitatsmedizin Berlin, Campus Virchow Klinikum, Berlin, Germany
Ann Neurol 64:664-73. 2008..We investigated the role of the Fas death receptor pathway in oxygen-triggered developmental brain injury... - Neuronal damage after moderate hypoxia and erythropoietinAstrid Weber
Department of Neonatology, Campus Virchow-Klinikum, Berlin, Germany
Neurobiol Dis 20:594-600. 2005..Thus, erythropoietin may aggravate rather than ameliorate neuronal damage when administered during transient hypoxia... - Pathways leading to apoptotic neurodegeneration following trauma to the developing rat brainUrsula Felderhoff-Mueser
Department of Neonatology, , Humboldt University, 13353 Berlin, Germany
Neurobiol Dis 11:231-45. 2002..Upregulation of neurotrophin expression may represent an endogenous mechanism that limits this apoptotic process... - Erythropoietin protects the developing brain against N-methyl-D-aspartate receptor antagonist neurotoxicityMark Dzietko
Department of Neonatology, Charit, Campus Virchow Klinikum, Humboldt University Berlin, Berlin, Germany
Neurobiol Dis 15:177-87. 2004..These observations indicate that rEPO partly rescues newborn rats from MK801-mediated brain damage by enhancing neurotrophin-associated signaling pathways... - Vascular endothelial growth factor and transforming growth factor-beta1 are highly expressed in the cerebrospinal fluid of premature infants with posthemorrhagic hydrocephalusAxel Heep
Department of Neonatology, University of Bonn, Adenauerallee 119, D 53113 Bonn, Germany
Pediatr Res 56:768-74. 2004..TGF-beta1 CSF concentrations are not elevated in the phase of acute fibroproliferative reactions in patients with PHHC... - Suramin induces and enhances apoptosis in a model of hyperoxia-induced oligodendrocyte injurySimone Stark
Department of Neonatology, Campus Virchow Klinikum, Charite, Universitatsmedizin Berlin, D 13353 Berlin, Germany
Neurotox Res 13:197-207. 2008..Its mechanism of action includes an increase of previously described hyperoxia-induced expression of pro-apoptotic factors and deprivation of growth factor dependent signaling components... - Neuropathological and biochemical features of traumatic injury in the developing brainPetra Bittigau
Departments of Pediatric Neurology and Neonatology, , Humboldt University, Augustenburger Platz 1, 13353 Berlin, Germany
Neurotox Res 5:475-90. 2003..These results help explain unfavorable outcomes of very young pediatric head trauma patients and imply that regimens which target slow active forms of cell death may comprise a successful neuroprotective approach... - Apoptotic neurodegeneration in the context of traumatic injury to the developing brainPetra Bittigau
Department of Pediatric Neurology, Charit, Virchow Campus, Children's Hospital, Humboldt University, Augustenburger Platz 1, Berlin 13353, Germany
Exp Toxicol Pathol 56:83-9. 2004.... - Effects of repetitive exposure to pain and morphine treatment on the neonatal rat brainLasse Dührsen
Department of Neonatology, Charite Universitatsmedizin Berlin, Berlin, Germany
Neonatology 103:35-43. 2013..Morphine may only protect the newborn brain against these changes in specific situations... - Expression of soluble Fas in the cerebrospinal fluid of preterm infants with posthemorrhagic hydrocephalus and cystic white matter damageThomas Schmitz
Department of Neonatology, Charite Universitatsmedizin Berlin, Campus Virchow Klinikum, Berlin D 13353, Germany
J Perinat Med 39:83-8. 2011..These results indicate that apoptosis via the Fas pathway is involved in the pathogenesis of cWMD in the context of PHHC, and that sFas in the CSF may serve as a marker of cWMD development... - Anticancer agents are potent neurotoxins in vitro and in vivoWojciech Rzeski
Department of Pediatric Neurology, Charit, Campus Virchow Klinikum, Humboldt University Berlin, Berlin, Germany
Ann Neurol 56:351-60. 2004..These results demonstrate that anticancer drugs are potent neurotoxins in vitro and in vivo; they activate excitotoxic mechanisms but also trigger active neuronal death... - Interaction of inflammation and hyperoxia in a rat model of neonatal white matter damageFelix Brehmer
Department of Neonatology, Charite University Medical Center, Berlin, Germany
PLoS ONE 7:e49023. 2012..The knowledge about mechanisms that triggered hypomyelination contributes to a better understanding of WMD in premature born infants... - IL-18: a key player in neuroinflammation and neurodegeneration?Ursula Felderhoff-Mueser
Department of Neonatology, Campus Virchow Klinikum, Charite University Medical School, 13353 Berlin, Germany
Trends Neurosci 28:487-93. 2005..This review provides a synopsis of the current knowledge of IL-18-dependent mechanisms of action during acute neurodegeneration in immature and adult brains... - High thrombopoietin concentrations in the cerebrospinal fluid of neonates with sepsis and intraventricular hemorrhage may contribute to brain damageAnke Reinhold
Department of Neonatology, Campus Virchow Klinikum, Charite Universitatsmedizin Berlin, D 13353 Berlin, Germany
J Interferon Cytokine Res 27:137-45. 2007..In conclusion, our data provide evidence that in neuronal cells, TPO production is regulated by different mechanisms than in hepatocytes... - Clinical measures to preserve cerebral integrity in preterm infantsUrsula Felderhoff-Mueser
Department of Neonatology, , Berlin, Germany
Early Hum Dev 81:237-44. 2005..This finding emphasizes the need to include these late endpoints in any randomized trial involving preterm infants... - Acute and long-term proteome changes induced by oxidative stress in the developing brainA M Kaindl
Department of Pediatric Neurology, Charite, University Medical School, Campus Virchow Klinikum, Augustenburger Platz 1, 13353 Berlin, Germany
Cell Death Differ 13:1097-109. 2006..These effects are age-dependent, as they did not occur in mice subjected to hyperoxia in adolescence... - Progressive multicystic encephalopathy: is there more than hypoxia-ischemia?Lars Garten
Department of Neonatology, University Charité, Berlin, Germany
J Child Neurol 22:645-9. 2007..As in this case, if the criteria of an acute hypoxic event sufficient to cause neonatal encephalopathy are not met, then factors other than hypoxia-ischemia may be leading to progressive multicystic encephalopathy... - The ambiguous role of nitric oxide in the developing brainThomas Hoehn
J Pediatr 142:215-6; author reply 216-7. 2003 - Hyperoxia causes inducible nitric oxide synthase-mediated cellular damage to the immature rat brainThomas Hoehn
Neonatology and Pediatric Intensive Care, University Children s Hospital, Heinrich Heine University, Moorenstr 5, 40225 Dusseldorf, Germany
Pediatr Res 54:179-84. 2003..Positive neuronal nitrotyrosine staining indicates formation of peroxynitrite with potential deleterious effects for immature cellular structures in the neonatal brain... - Hyperoxia causes maturation-dependent cell death in the developing white matterBettina Gerstner
Department of Neurology and the F M Kirby Neurobiology Center, Children s Hospital Boston, Boston, Massachusetts 02115, USA
J Neurosci 28:1236-45. 2008..These observations may be relevant to white matter injury observed in premature infants... - Vascular endothelial growth factor and erythropoietin concentrations in cerebrospinal fluid of children with hydrocephalusPetra Koehne
, , 13344 Berlin, Germany
Childs Nerv Syst 18:137-41. 2002..1 pg/ml) in 34 of 57 hydrocephalus samples and in 34 of 41 controls. CONCLUSION: We conclude that conditions necessitating surgical intervention in hydrocephalus patients result in increased CSF concentrations of VEGF and EPO... - NMDA antagonist inhibits the extracellular signal-regulated kinase pathway and suppresses cancer growthAndrzej Stepulak
Department of Pediatric Neurology, Technical University, 01307 Dresden, Germany
Proc Natl Acad Sci U S A 102:15605-10. 2005..These findings reveal the mechanism of antiproliferative action of dizocilpine and indicate that it may be useful in the therapy of human cancers... - Erythropoietin and ischemic conditioning--why two good things may be badChristoph Buhrer
Department of Neonatology, Basel University Children s Hospital, Basel, Switzerland
Acta Paediatr 96:787-9. 2007