Ursula Felderhoff-Mueser

Summary

Affiliation: Humboldt University
Country: Germany

Publications

  1. ncbi request reprint Oxygen causes cell death in the developing brain
    Ursula Felderhoff-Mueser
    Department of Neonatology, Humboldt University Berlin, Charite, Campus Virchow Klinikum, 13353 Berlin, Germany
    Neurobiol Dis 17:273-82. 2004
  2. ncbi request reprint Caspase-1-processed interleukins in hyperoxia-induced cell death in the developing brain
    Ursula Felderhoff-Mueser
    Department of Neonatology, Charite, Campus Virchow Klinikum, Humboldt University Medical Center, Augustenburger Platz 1, D 13353 Berlin, Germany
    Ann Neurol 57:50-9. 2005
  3. pmc Elevated nerve growth factor and neurotrophin-3 levels in cerebrospinal fluid of children with hydrocephalus
    F Hochhaus
    Neonatology, Charite, Campus Virchow Klinikum, Humboldt University, Berlin, Germany
    BMC Pediatr 1:2. 2001
  4. pmc Increased cerebrospinal fluid concentrations of soluble Fas (CD95/Apo-1) in hydrocephalus
    U Felderhoff-Mueser
    Department of Neonatology, Charite Children s Hospital, Virchow Klinikum, Humboldt University, Augustenburger Platz 1, 13353 Berlin, Germany
    Arch Dis Child 84:369-72. 2001
  5. ncbi request reprint Intrauterine onset of acute neuropathic type 2 Gaucher disease: identification of a novel insertion sequence
    Ursula Felderhoff-Mueser
    Department of Neonatology, Charite, Campus Virchow Klinikum, Berlin, Germany
    Am J Med Genet A 128:138-43. 2004
  6. ncbi request reprint Soluble Fas (CD95/Apo-1), soluble Fas ligand, and activated caspase 3 in the cerebrospinal fluid of infants with posthemorrhagic and nonhemorrhagic hydrocephalus
    Ursula Felderhoff-Mueser
    Department of Neonatology, Charite, Children s Hospital, Campus Virchow Klinikum, D 13353 Berlin, Germany
    Pediatr Res 54:659-64. 2003
  7. ncbi request reprint Severe spinal muscular atrophy variant associated with congenital bone fractures
    Ursula Felderhoff-Mueser
    Department of Neonatology, Humboldt University, Berlin, Germany
    J Child Neurol 17:718-21. 2002
  8. ncbi request reprint 31Phosphorus magnetic resonance spectroscopy in late-onset Tay-Sachs disease
    U Felderhoff-Mueser
    Department of Neonatology, Charite Children s Hospital, Humboldt University, Berlin, Germany
    J Child Neurol 16:377-80. 2001
  9. ncbi request reprint Protection with estradiol in developmental models of apoptotic neurodegeneration
    Stiliani Asimiadou
    Neuroscience Research Center, Charite, Humboldt University Berlin, Berlin, Germany
    Ann Neurol 58:266-76. 2005
  10. ncbi request reprint Erythropoietin protects the developing brain from hyperoxia-induced cell death and proteome changes
    Angela M Kaindl
    Department of Pediatric Neurology, Charite Universitatsmedizin Berlin, Campus Virchow Klinikum, Berlin, Germany
    Ann Neurol 64:523-34. 2008

Collaborators

Detail Information

Publications40

  1. ncbi request reprint Oxygen causes cell death in the developing brain
    Ursula Felderhoff-Mueser
    Department of Neonatology, Humboldt University Berlin, Charite, Campus Virchow Klinikum, 13353 Berlin, Germany
    Neurobiol Dis 17:273-82. 2004
    ..Our findings reveal a mechanism that could potentially damage the developing brain of human premature neonates...
  2. ncbi request reprint Caspase-1-processed interleukins in hyperoxia-induced cell death in the developing brain
    Ursula Felderhoff-Mueser
    Department of Neonatology, Charite, Campus Virchow Klinikum, Humboldt University Medical Center, Augustenburger Platz 1, D 13353 Berlin, Germany
    Ann Neurol 57:50-9. 2005
    ..These cytokines might serve as useful targets for therapeutic approaches aimed at preserving neuronal function in the immature brain, which is exquisitely sensitive to a variety of iatrogenic measures including oxygen...
  3. pmc Elevated nerve growth factor and neurotrophin-3 levels in cerebrospinal fluid of children with hydrocephalus
    F Hochhaus
    Neonatology, Charite, Campus Virchow Klinikum, Humboldt University, Berlin, Germany
    BMC Pediatr 1:2. 2001
    ..We investigated whether concentrations of NGF and NT-3 are increased in the CSF of children with hydrocephalus...
  4. pmc Increased cerebrospinal fluid concentrations of soluble Fas (CD95/Apo-1) in hydrocephalus
    U Felderhoff-Mueser
    Department of Neonatology, Charite Children s Hospital, Virchow Klinikum, Humboldt University, Augustenburger Platz 1, 13353 Berlin, Germany
    Arch Dis Child 84:369-72. 2001
    ..One of the regulators of the apoptotic cell death programme is the receptor mediated Fas/Fas ligand interaction...
  5. ncbi request reprint Intrauterine onset of acute neuropathic type 2 Gaucher disease: identification of a novel insertion sequence
    Ursula Felderhoff-Mueser
    Department of Neonatology, Charite, Campus Virchow Klinikum, Berlin, Germany
    Am J Med Genet A 128:138-43. 2004
    ..The transheterozygous combination of a mutation, previously described in type 1 Gaucher disease, together with a newly identified insertion may result in this severe phenotype...
  6. ncbi request reprint Soluble Fas (CD95/Apo-1), soluble Fas ligand, and activated caspase 3 in the cerebrospinal fluid of infants with posthemorrhagic and nonhemorrhagic hydrocephalus
    Ursula Felderhoff-Mueser
    Department of Neonatology, Charite, Children s Hospital, Campus Virchow Klinikum, D 13353 Berlin, Germany
    Pediatr Res 54:659-64. 2003
    ..Increased intrathecal release of sFas in the cerebrospinal fluid of infants with hydrocephalus may serve as an indicator of brain injury from progressive ventricular dilatation...
  7. ncbi request reprint Severe spinal muscular atrophy variant associated with congenital bone fractures
    Ursula Felderhoff-Mueser
    Department of Neonatology, Humboldt University, Berlin, Germany
    J Child Neurol 17:718-21. 2002
    ..We present clinical, molecular, and autopsy findings of a newborn boy presenting with generalized muscular atrophy in combination with congenital bone fractures and extremely thin ribs but without contractures...
  8. ncbi request reprint 31Phosphorus magnetic resonance spectroscopy in late-onset Tay-Sachs disease
    U Felderhoff-Mueser
    Department of Neonatology, Charite Children s Hospital, Humboldt University, Berlin, Germany
    J Child Neurol 16:377-80. 2001
    ..The clinical findings were well related to the changes in spectroscopically determined metabolites...
  9. ncbi request reprint Protection with estradiol in developmental models of apoptotic neurodegeneration
    Stiliani Asimiadou
    Neuroscience Research Center, Charite, Humboldt University Berlin, Berlin, Germany
    Ann Neurol 58:266-76. 2005
    ..Its supplementation may particularly help to improve neurocognitive outcome in preterm infants who are prematurely deprived of maternal estrogen...
  10. ncbi request reprint Erythropoietin protects the developing brain from hyperoxia-induced cell death and proteome changes
    Angela M Kaindl
    Department of Pediatric Neurology, Charite Universitatsmedizin Berlin, Campus Virchow Klinikum, Berlin, Germany
    Ann Neurol 64:523-34. 2008
    ..Because a tissue-protective effect has been observed for recombinant erythropoietin (rEpo), widely used in neonatal medicine for its hematopoietic effect, we examined the effect of rEpo on hyperoxia-induced brain damage...
  11. ncbi request reprint Activation of caspase-1 dependent interleukins in developmental brain trauma
    Marco Sifringer
    Department of Pediatric Neurology, Children s Hospital, Medical Faculty Carl Gustav Carus, Technical University Dresden, 01307 Dresden, Germany
    Neurobiol Dis 25:614-22. 2007
    ..These findings indicate that IL-18 is involved in trauma-induced neuronal cell death in the immature rodent brain and might serve as a potential therapeutic target...
  12. ncbi request reprint Fas (CD95/Apo-1)/Fas ligand expression in neonates with pontosubicular neuron necrosis
    Frank K H van Landeghem
    Institute of Neuropathology, Charite, Campus Virchow Klinikum, Humboldt University, Augustenburger Platz 1, D 13353 Berlin, Germany
    Pediatr Res 51:129-35. 2002
    ..There was no significant difference between cases with and without PSN. We conclude that in the developing human brain, cells expressing the Fas receptor may be susceptible to undergoing apoptosis in response to hypoxic-ischemic injury...
  13. ncbi request reprint Estradiol attenuates hyperoxia-induced cell death in the developing white matter
    Bettina Gerstner
    Department of Neonatology, Charite Campus Virchow Klinikum, Berlin, Germany
    Ann Neurol 61:562-73. 2007
    ..Furthermore, neuroprotective properties have been attributed to estrogens. We examined the effect of E2 on hyperoxia-induced cell death in the developing white matter in the rat brain...
  14. ncbi request reprint Maturation-dependent oligodendrocyte apoptosis caused by hyperoxia
    Bettina Gerstner
    Department of Neonatology, Charite Campus Virchow Klinikum, Berlin, Germany
    J Neurosci Res 84:306-15. 2006
    ..Hyperoxia triggers maturation-dependent apoptosis in immature and pre-OLs and involves caspase activation. This mechanism may be relevant to the white matter injury observed in infants born preterm...
  15. ncbi request reprint Erythropoietin attenuates hyperoxia-induced oxidative stress in the developing rat brain
    Marco Sifringer
    Department of Neonatology, Charite Universitatsmedizin Berlin, Berlin, Germany
    Brain Behav Immun 24:792-9. 2010
    ..Our results suggest that rEpo generates its protective effect against oxygen toxicity by a reduction of diverse oxidative stress parameters and by limiting the stressor-inducible changes in both HO-1 and cholinergic functions...
  16. doi request reprint Erythropoietin attenuates hyperoxia-induced cell death by modulation of inflammatory mediators and matrix metalloproteinases
    Marco Sifringer
    Department of Neonatology, Campus Virchow Klinikum, Charite Universitatsmedizin Berlin, Berlin, Germany
    Dev Neurosci 31:394-402. 2009
    ..Our results suggest that rEpo generates its protective effect against oxygen toxicity through a reduction of proinflammatory mediator levels...
  17. ncbi request reprint Erythropoietin protects the developing brain against N-methyl-D-aspartate receptor antagonist neurotoxicity
    Mark Dzietko
    Department of Neonatology, Charite, Campus Virchow Klinikum, Humboldt University Berlin, Berlin, Germany
    Neurobiol Dis 15:177-87. 2004
    ..These observations indicate that rEPO partly rescues newborn rats from MK801-mediated brain damage by enhancing neurotrophin-associated signaling pathways...
  18. doi request reprint A critical role for Fas/CD-95 dependent signaling pathways in the pathogenesis of hyperoxia-induced brain injury
    Mark Dzietko
    Department of Neonatology, Charite, Universitatsmedizin Berlin, Campus Virchow Klinikum, Berlin, Germany
    Ann Neurol 64:664-73. 2008
    ..We investigated the role of the Fas death receptor pathway in oxygen-triggered developmental brain injury...
  19. doi request reprint Oxygen toxicity is reduced by acetylcholinesterase inhibition in the developing rat brain
    Marco Sifringer
    Department of Anesthesiology and Intensive Care Medicine, Campus Charité Mitte and Campus Virchow Klinikum, Charite Universitatsmedizin Berlin, Berlin, Germany
    Dev Neurosci 35:255-64. 2013
    ....
  20. ncbi request reprint Neuronal damage after moderate hypoxia and erythropoietin
    Astrid Weber
    Department of Neonatology, Campus Virchow Klinikum, Berlin, Germany
    Neurobiol Dis 20:594-600. 2005
    ..Thus, erythropoietin may aggravate rather than ameliorate neuronal damage when administered during transient hypoxia...
  21. ncbi request reprint Pathways leading to apoptotic neurodegeneration following trauma to the developing rat brain
    Ursula Felderhoff-Mueser
    Department of Neonatology, Charite Children s Hospital, Humboldt University, 13353 Berlin, Germany
    Neurobiol Dis 11:231-45. 2002
    ..Upregulation of neurotrophin expression may represent an endogenous mechanism that limits this apoptotic process...
  22. ncbi request reprint Vascular endothelial growth factor and transforming growth factor-beta1 are highly expressed in the cerebrospinal fluid of premature infants with posthemorrhagic hydrocephalus
    Axel Heep
    Department of Neonatology, University of Bonn, Adenauerallee 119, D 53113 Bonn, Germany
    Pediatr Res 56:768-74. 2004
    ..TGF-beta1 CSF concentrations are not elevated in the phase of acute fibroproliferative reactions in patients with PHHC...
  23. pmc Interaction of inflammation and hyperoxia in a rat model of neonatal white matter damage
    Felix Brehmer
    Department of Neonatology, Charite University Medical Center, Berlin, Germany
    PLoS ONE 7:e49023. 2012
    ..The knowledge about mechanisms that triggered hypomyelination contributes to a better understanding of WMD in premature born infants...
  24. doi request reprint Effects of repetitive exposure to pain and morphine treatment on the neonatal rat brain
    Lasse Dührsen
    Department of Neonatology, Charite Universitatsmedizin Berlin, Berlin, Germany
    Neonatology 103:35-43. 2013
    ..Untreated exposure to pain in preterm neonates might damage the vulnerable premature brain and alter development. Pain treatment is limited because analgesic agents may also have adverse neurodevelopmental consequences in newborns...
  25. ncbi request reprint Suramin induces and enhances apoptosis in a model of hyperoxia-induced oligodendrocyte injury
    Simone Stark
    Department of Neonatology, Campus Virchow Klinikum, Charite, Universitatsmedizin Berlin, D 13353 Berlin, Germany
    Neurotox Res 13:197-207. 2008
    ..Its mechanism of action includes an increase of previously described hyperoxia-induced expression of pro-apoptotic factors and deprivation of growth factor dependent signaling components...
  26. ncbi request reprint Neuropathological and biochemical features of traumatic injury in the developing brain
    Petra Bittigau
    Departments of Pediatric Neurology and Neonatology, Charite Children s Hospital, Humboldt University, Augustenburger Platz 1, 13353 Berlin, Germany
    Neurotox Res 5:475-90. 2003
    ..These results help explain unfavorable outcomes of very young pediatric head trauma patients and imply that regimens which target slow active forms of cell death may comprise a successful neuroprotective approach...
  27. ncbi request reprint Apoptotic neurodegeneration in the context of traumatic injury to the developing brain
    Petra Bittigau
    Department of Pediatric Neurology, Charite, Virchow Campus, Children s Hospital, Humboldt University, Augustenburger Platz 1, Berlin 13353, Germany
    Exp Toxicol Pathol 56:83-9. 2004
    ....
  28. doi request reprint Expression of soluble Fas in the cerebrospinal fluid of preterm infants with posthemorrhagic hydrocephalus and cystic white matter damage
    Thomas Schmitz
    Department of Neonatology, Charite Universitatsmedizin Berlin, Campus Virchow Klinikum, Berlin D 13353, Germany
    J Perinat Med 39:83-8. 2011
    ..These results indicate that apoptosis via the Fas pathway is involved in the pathogenesis of cWMD in the context of PHHC, and that sFas in the CSF may serve as a marker of cWMD development...
  29. ncbi request reprint Anticancer agents are potent neurotoxins in vitro and in vivo
    Wojciech Rzeski
    Department of Pediatric Neurology, Charite, Campus Virchow Klinikum, Humboldt University Berlin, Berlin, Germany
    Ann Neurol 56:351-60. 2004
    ..These results demonstrate that anticancer drugs are potent neurotoxins in vitro and in vivo; they activate excitotoxic mechanisms but also trigger active neuronal death...
  30. ncbi request reprint High thrombopoietin concentrations in the cerebrospinal fluid of neonates with sepsis and intraventricular hemorrhage may contribute to brain damage
    Anke Reinhold
    Department of Neonatology, Campus Virchow Klinikum, Charite Universitatsmedizin Berlin, D 13353 Berlin, Germany
    J Interferon Cytokine Res 27:137-45. 2007
    ..In conclusion, our data provide evidence that in neuronal cells, TPO production is regulated by different mechanisms than in hepatocytes...
  31. ncbi request reprint Clinical measures to preserve cerebral integrity in preterm infants
    Ursula Felderhoff-Mueser
    Department of Neonatology, Charite Campus Virchow Klinikum, Berlin, Germany
    Early Hum Dev 81:237-44. 2005
    ..This finding emphasizes the need to include these late endpoints in any randomized trial involving preterm infants...
  32. ncbi request reprint Acute and long-term proteome changes induced by oxidative stress in the developing brain
    A M Kaindl
    Department of Pediatric Neurology, Charite, University Medical School, Campus Virchow Klinikum, Augustenburger Platz 1, 13353 Berlin, Germany
    Cell Death Differ 13:1097-109. 2006
    ..These effects are age-dependent, as they did not occur in mice subjected to hyperoxia in adolescence...
  33. ncbi request reprint IL-18: a key player in neuroinflammation and neurodegeneration?
    Ursula Felderhoff-Mueser
    Department of Neonatology, Campus Virchow Klinikum, Charite University Medical School, 13353 Berlin, Germany
    Trends Neurosci 28:487-93. 2005
    ..This review provides a synopsis of the current knowledge of IL-18-dependent mechanisms of action during acute neurodegeneration in immature and adult brains...
  34. ncbi request reprint Progressive multicystic encephalopathy: is there more than hypoxia-ischemia?
    Lars Garten
    Department of Neonatology, University Charité, Berlin, Germany
    J Child Neurol 22:645-9. 2007
    ..As in this case, if the criteria of an acute hypoxic event sufficient to cause neonatal encephalopathy are not met, then factors other than hypoxia-ischemia may be leading to progressive multicystic encephalopathy...
  35. ncbi request reprint Hyperoxia causes inducible nitric oxide synthase-mediated cellular damage to the immature rat brain
    Thomas Hoehn
    Neonatology and Pediatric Intensive Care, University Children s Hospital, Heinrich Heine University, Moorenstr 5, 40225 Dusseldorf, Germany
    Pediatr Res 54:179-84. 2003
    ..Positive neuronal nitrotyrosine staining indicates formation of peroxynitrite with potential deleterious effects for immature cellular structures in the neonatal brain...
  36. ncbi request reprint The ambiguous role of nitric oxide in the developing brain
    Thomas Hoehn
    J Pediatr 142:215-6; author reply 216-7. 2003
  37. doi request reprint Hyperoxia causes maturation-dependent cell death in the developing white matter
    Bettina Gerstner
    Department of Neurology and the F M Kirby Neurobiology Center, Children s Hospital Boston, Boston, Massachusetts 02115, USA
    J Neurosci 28:1236-45. 2008
    ..These observations may be relevant to white matter injury observed in premature infants...
  38. ncbi request reprint Vascular endothelial growth factor and erythropoietin concentrations in cerebrospinal fluid of children with hydrocephalus
    Petra Koehne
    Klinik für Neonatologie, Charite Virchow Klinikum, 13344 Berlin, Germany
    Childs Nerv Syst 18:137-41. 2002
    ..We set up the hypothesis that elevated intracranial pressure in patients with hydrocephalus triggers release of VEGF and EPO into cerebrospinal fluid (CSF)...
  39. ncbi request reprint Erythropoietin and ischemic conditioning--why two good things may be bad
    Christoph Buhrer
    Department of Neonatology, Basel University Children s Hospital, Basel, Switzerland
    Acta Paediatr 96:787-9. 2007
  40. pmc NMDA antagonist inhibits the extracellular signal-regulated kinase pathway and suppresses cancer growth
    Andrzej Stepulak
    Department of Pediatric Neurology, Technical University, 01307 Dresden, Germany
    Proc Natl Acad Sci U S A 102:15605-10. 2005
    ..These findings reveal the mechanism of antiproliferative action of dizocilpine and indicate that it may be useful in the therapy of human cancers...