Hans Jörg Epple

Summary

Affiliation: Humboldt University
Country: Germany

Publications

  1. doi request reprint HIV infection and the intestinal mucosal barrier
    Hans Jörg Epple
    Department of Gastroenterology, Infectious Diseases and Rheumatology, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany
    Ann N Y Acad Sci 1258:19-24. 2012
  2. doi request reprint Therapy- and non-therapy-dependent infectious complications in inflammatory bowel disease
    Hans Jörg Epple
    Medical Clinic I, Gastroenterology, Rheumatology, Infectiology, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany
    Dig Dis 27:555-9. 2009
  3. ncbi request reprint Mucosal but not peripheral FOXP3+ regulatory T cells are highly increased in untreated HIV infection and normalize after suppressive HAART
    Hans Jörg Epple
    Medical Clinic I, Gastroenterology, Rheumatology, Infectiology Charité Universitätsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, Germany
    Blood 108:3072-8. 2006
  4. doi request reprint [Infectious enteritis]
    H J Epple
    Medizinische Klinik für Gastroenterologie, Infektiologie, Rheumatologie, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Deutschland
    Internist (Berl) 52:1038, 1040-4, 1046. 2011
  5. doi request reprint Acute HIV infection induces mucosal infiltration with CD4+ and CD8+ T cells, epithelial apoptosis, and a mucosal barrier defect
    Hans Jörg Epple
    Medical Clinic I, Gastroenterology, Rheumatology, Infectiology, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, Berlin, Germany
    Gastroenterology 139:1289-300. 2010
  6. ncbi request reprint Effect of Age on the CD4+ T-Cell Impairment in HIV-Infected Persons Without and With cART
    Kristina Allers
    Department of Gastroenterology, Infectious Diseases, and Rheumatology, Medical Clinic I, Campus Benjamin Franklin, Charite University Medicine Berlin, Berlin, Germany and Ärzteforum Seestraβe, Berlin, Germany Heiko Karcher is now with Ärzteforum Praxis City Ost, Berlin, Germany Desiree Kunkel is now with Berlin Brandenburg Center for Regenerative Therapies, Campus Virchow Klinikum, Charite University Medicine Berlin, Berlin, Germany
    J Acquir Immune Defic Syndr 66:7-15. 2014
  7. doi request reprint Aerolysin from Aeromonas hydrophila perturbs tight junction integrity and cell lesion repair in intestinal epithelial HT-29/B6 cells
    Roland Bücker
    Department of Gastroenterology, Infectious Diseases, and Rheumotology, Charite Berlin, Germany
    J Infect Dis 204:1283-92. 2011
  8. pmc Gut mucosal FOXP3+ regulatory CD4+ T cells and Nonregulatory CD4+ T cells are differentially affected by simian immunodeficiency virus infection in rhesus macaques
    Kristina Allers
    Medical Clinic I Gastroenterology, Infectious Diseases and Rheumatology, Charite Campus Benjamin Franklin, Hindenburgdamm 30, 12203 Berlin, Germany
    J Virol 84:3259-69. 2010
  9. ncbi request reprint Macrophages accumulate in the gut mucosa of untreated HIV-infected patients
    Kristina Allers
    Department of Gastroenterology, Infectious Diseases, and Rheumatology, Medical Clinic I, Campus Benjamin Franklin
    J Infect Dis 209:739-48. 2014
  10. pmc Cytokine expression in the colonic mucosa of human immunodeficiency virus-infected individuals before and during 9 months of antiretroviral therapy
    Hubert Schulbin
    Medizinische Klinik I, Charite, Campus Benjamin Franklin, Berlin, Germany
    Antimicrob Agents Chemother 52:3377-84. 2008

Collaborators

Detail Information

Publications14

  1. doi request reprint HIV infection and the intestinal mucosal barrier
    Hans Jörg Epple
    Department of Gastroenterology, Infectious Diseases and Rheumatology, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany
    Ann N Y Acad Sci 1258:19-24. 2012
    ..After prolonged viral suppression by antiretroviral therapy, there is, at least partial, restoration of the HIV-associated intestinal mucosal barrier defect despite persisting alterations of the mucosal immune system...
  2. doi request reprint Therapy- and non-therapy-dependent infectious complications in inflammatory bowel disease
    Hans Jörg Epple
    Medical Clinic I, Gastroenterology, Rheumatology, Infectiology, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany
    Dig Dis 27:555-9. 2009
    ..Patients with inflammatory bowel disease (IBD) are susceptible to infections...
  3. ncbi request reprint Mucosal but not peripheral FOXP3+ regulatory T cells are highly increased in untreated HIV infection and normalize after suppressive HAART
    Hans Jörg Epple
    Medical Clinic I, Gastroenterology, Rheumatology, Infectiology Charité Universitätsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, Germany
    Blood 108:3072-8. 2006
    ..Their role may be 2-edged: attenuating HIV-induced immune hyperactivation while suppressing the immune response to HIV and mucosal pathogens...
  4. doi request reprint [Infectious enteritis]
    H J Epple
    Medizinische Klinik für Gastroenterologie, Infektiologie, Rheumatologie, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Deutschland
    Internist (Berl) 52:1038, 1040-4, 1046. 2011
    ....
  5. doi request reprint Acute HIV infection induces mucosal infiltration with CD4+ and CD8+ T cells, epithelial apoptosis, and a mucosal barrier defect
    Hans Jörg Epple
    Medical Clinic I, Gastroenterology, Rheumatology, Infectiology, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, Berlin, Germany
    Gastroenterology 139:1289-300. 2010
    ..We analyzed T-cell subsets, epithelial apoptosis, and barrier function of the duodenal mucosa in patients with acute HIV infection...
  6. ncbi request reprint Effect of Age on the CD4+ T-Cell Impairment in HIV-Infected Persons Without and With cART
    Kristina Allers
    Department of Gastroenterology, Infectious Diseases, and Rheumatology, Medical Clinic I, Campus Benjamin Franklin, Charite University Medicine Berlin, Berlin, Germany and Ärzteforum Seestraβe, Berlin, Germany Heiko Karcher is now with Ärzteforum Praxis City Ost, Berlin, Germany Desiree Kunkel is now with Berlin Brandenburg Center for Regenerative Therapies, Campus Virchow Klinikum, Charite University Medicine Berlin, Berlin, Germany
    J Acquir Immune Defic Syndr 66:7-15. 2014
    ..Knowledge about HIV infection in older persons is becoming increasingly important. CD4 T cells are essential for protective immunity, but little is known about the effect of age on the CD4 T-cell impairment in HIV infection...
  7. doi request reprint Aerolysin from Aeromonas hydrophila perturbs tight junction integrity and cell lesion repair in intestinal epithelial HT-29/B6 cells
    Roland Bücker
    Department of Gastroenterology, Infectious Diseases, and Rheumotology, Charite Berlin, Germany
    J Infect Dis 204:1283-92. 2011
    ..Pathogenesis of Aeromonas hydrophila and its hemolysin has been characterized, but the mechanism of the epithelial barrier dysfunction is currently poorly understood...
  8. pmc Gut mucosal FOXP3+ regulatory CD4+ T cells and Nonregulatory CD4+ T cells are differentially affected by simian immunodeficiency virus infection in rhesus macaques
    Kristina Allers
    Medical Clinic I Gastroenterology, Infectious Diseases and Rheumatology, Charite Campus Benjamin Franklin, Hindenburgdamm 30, 12203 Berlin, Germany
    J Virol 84:3259-69. 2010
    ..Although SIV production is limited in mucosal T(reg), T(reg) accumulation may indirectly contribute to viral persistence by suppressing antiviral immune responses...
  9. ncbi request reprint Macrophages accumulate in the gut mucosa of untreated HIV-infected patients
    Kristina Allers
    Department of Gastroenterology, Infectious Diseases, and Rheumatology, Medical Clinic I, Campus Benjamin Franklin
    J Infect Dis 209:739-48. 2014
    ..Although an intestinal barrier defect and microbial translocation are hallmarks of human immunodeficiency virus (HIV) infection, recent data on gut mucosal macrophages in HIV infection are sparse...
  10. pmc Cytokine expression in the colonic mucosa of human immunodeficiency virus-infected individuals before and during 9 months of antiretroviral therapy
    Hubert Schulbin
    Medizinische Klinik I, Charite, Campus Benjamin Franklin, Berlin, Germany
    Antimicrob Agents Chemother 52:3377-84. 2008
    ..Despite reductions in levels of mucosal HIV RNA and the restoration of mucosal CD4(+) T lymphocytes, antiretroviral therapy failed to restore the normal colonic immunologic environment...
  11. ncbi request reprint Escherichia coli alpha-haemolysin induces focal leaks in colonic epithelium: a novel mechanism of bacterial translocation
    Hanno Troeger
    Department of Gastroenterology, Infectious Diseases and Rheumatology, Campus Benjamin Franklin, Charite, Berlin, Germany
    Cell Microbiol 9:2530-40. 2007
    ..E. coli alpha-haemolysin is able to induce focal leaks in colonic cell cultures as well as in native colon. This process represents a novel route of bacterial translocation facilitated by pro-inflammatory cytokines...
  12. ncbi request reprint Cytokine-dependent transcriptional down-regulation of epithelial sodium channel in ulcerative colitis
    Salah Amasheh
    Department of Clinical Physiology, Campus Benjamin Franklin, Charite University Medicine Berlin, Hindenburgdamm 30, 12200 Berlin, Germany
    Gastroenterology 126:1711-20. 2004
    ..This study aimed to characterize mechanisms involved in the dysregulation of ENaC expression in ulcerative colitis (UC)...
  13. pmc Rapid and accurate diagnosis of human intestinal spirochetosis by fluorescence in situ hybridization
    Dinah Schmiedel
    Institut für Mikrobiologie und Hygiene, Charite Universitatsmedizin Berlin, Charite Campus Mitte, Berlin, Germany
    J Clin Microbiol 47:1393-401. 2009
    ..In conclusion, FISH provides a fast and accurate technique for the visualization and identification of intestinal spirochetes in tissue sections. It therefore represents a valuable tool for routine diagnosis of HIS...
  14. doi request reprint [A young man with chronic diarrhea and epigastric pain]
    Juliane Buchkremer
    Medizinische Klinik für Gastroenterologie, Infektiologie und Rheumatologie, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany
    Med Klin (Munich) 105:242-5. 2010
    ..Subsequently, the diagnosis could be confirmed and the gastrinoma located. After successful pancreaticoduodenectomy, the patient was symptom-free...