S Engeli

Summary

Affiliation: Humboldt University
Country: Germany

Publications

  1. doi request reprint Dysregulation of the endocannabinoid system in obesity
    S Engeli
    Franz Volhard Clinical Research Center, Medical Faculty of the Charite, Berlin, Germany
    J Neuroendocrinol 20:110-5. 2008
  2. doi request reprint Peripheral metabolic effects of endocannabinoids and cannabinoid receptor blockade
    Stefan Engeli
    Franz Volhard Clinical Research Center at the Experimental and Clinical Research Center, Charite Campus Buch, Berlin, Germany
    Obes Facts 1:8-15. 2008
  3. ncbi request reprint Role of the renin-angiotensin- aldosterone system in the metabolic syndrome
    Stefan Engeli
    Franz Volhard Clinical Research Center, Charite Campus Buch, Berlin, Germany
    Contrib Nephrol 151:122-34. 2006
  4. pmc Peripheral endocannabinoid system activity in patients treated with sibutramine
    Stefan Engeli
    Franz Volhard Clinical Research Center, Medical Faculty of the Charité and HELIOS Klinikum, Berlin, Germany
    Obesity (Silver Spring) 16:1135-7. 2008
  5. ncbi request reprint The endocannabinoid system: body weight and metabolic regulation
    Stefan Engeli
    Franz Volhard Clinical Research Center, University Clinic Charité Campus Buch, Humboldt University of Berlin, Wiltbergstrasse 50, 13125 Berlin, Germany
    Clin Cornerstone 8:S24-35. 2006
  6. doi request reprint Neurohumoral and metabolic response to exercise in water
    S Wiesner
    Franz Volhard Clinical Research Center, Medical Faculty of the Charité and HELIOS Klinikum, Berlin, Germany
    Horm Metab Res 42:334-9. 2010
  7. ncbi request reprint Hemodynamic and metabolic responses to valsartan and atenolol in obese hypertensive patients
    Jens Jordan
    Franz Volhard Clinical Research Center, Medical Faculty of the Charité and HELIOS Klinikum, Berlin, Germany
    J Hypertens 23:2313-8. 2005
  8. doi request reprint Variations in truncal body circumferences affect fat mass quantification with bioimpedance analysis
    V Haas
    Franz Volhard Clinical Research Center at the Experimental and Clinical Research Center, Charité University Medicine Berlin and Max Delbrueck Center for Molecular Medicine, Berlin, Germany
    Eur J Clin Nutr 66:196-200. 2012
  9. ncbi request reprint Influences of AT1 receptor blockade on tissue metabolism in obese men
    Michael Boschmann
    Franz Volhard Clinical Research Center, Haus 129, Charite Campus Buch, Wiltbergstr 50, 13125 Berlin, Germany
    Am J Physiol Regul Integr Comp Physiol 290:R219-23. 2006
  10. ncbi request reprint Sympathetic vasomotor tone determines blood pressure response to long-term sibutramine treatment
    Karsten Heusser
    Franz Volhard Clinical Research Center, Medical Faculty of the Charité and HELIOS Klinikum, Berlin, Germany
    J Clin Endocrinol Metab 92:1560-3. 2007

Collaborators

Detail Information

Publications50

  1. doi request reprint Dysregulation of the endocannabinoid system in obesity
    S Engeli
    Franz Volhard Clinical Research Center, Medical Faculty of the Charite, Berlin, Germany
    J Neuroendocrinol 20:110-5. 2008
    ..Thus, activation of the ECS is a hallmark of abdominal obesity, and explains the success of pharmacological CB(1) blockade, but serious attempts have to be made to clarify the underlying mechanisms of this activation...
  2. doi request reprint Peripheral metabolic effects of endocannabinoids and cannabinoid receptor blockade
    Stefan Engeli
    Franz Volhard Clinical Research Center at the Experimental and Clinical Research Center, Charite Campus Buch, Berlin, Germany
    Obes Facts 1:8-15. 2008
    ..Despite the current discussion of safety issues of cannabinoid receptor blockade, these findings open a new and exciting perspective on endocannabinoids as regulators of body weight and metabolism...
  3. ncbi request reprint Role of the renin-angiotensin- aldosterone system in the metabolic syndrome
    Stefan Engeli
    Franz Volhard Clinical Research Center, Charite Campus Buch, Berlin, Germany
    Contrib Nephrol 151:122-34. 2006
    ..Thus, data from clinical trials clearly suggest that the RAAS plays an important role for the pathophysiology of the Metabolic Syndrome, but the molecular mechanisms are not understood very well at present...
  4. pmc Peripheral endocannabinoid system activity in patients treated with sibutramine
    Stefan Engeli
    Franz Volhard Clinical Research Center, Medical Faculty of the Charité and HELIOS Klinikum, Berlin, Germany
    Obesity (Silver Spring) 16:1135-7. 2008
    ..Weight loss interventions may influence obesity-associated risk indirectly through modulation of the peripheral ECS. We investigated the effect of acute and chronic treatment with sibutramine on components of the peripheral ECS...
  5. ncbi request reprint The endocannabinoid system: body weight and metabolic regulation
    Stefan Engeli
    Franz Volhard Clinical Research Center, University Clinic Charité Campus Buch, Humboldt University of Berlin, Wiltbergstrasse 50, 13125 Berlin, Germany
    Clin Cornerstone 8:S24-35. 2006
    ....
  6. doi request reprint Neurohumoral and metabolic response to exercise in water
    S Wiesner
    Franz Volhard Clinical Research Center, Medical Faculty of the Charité and HELIOS Klinikum, Berlin, Germany
    Horm Metab Res 42:334-9. 2010
    ..Even though water immersion blunts exercise-induced sympathoadrenal activation, lipid mobilization and lipid oxidation rate are maintained or even improved. The response may be explained by augmented ANP release...
  7. ncbi request reprint Hemodynamic and metabolic responses to valsartan and atenolol in obese hypertensive patients
    Jens Jordan
    Franz Volhard Clinical Research Center, Medical Faculty of the Charité and HELIOS Klinikum, Berlin, Germany
    J Hypertens 23:2313-8. 2005
    ..Treatment recommendations for lean hypertensives may not be simply extrapolated to obese hypertensive persons...
  8. doi request reprint Variations in truncal body circumferences affect fat mass quantification with bioimpedance analysis
    V Haas
    Franz Volhard Clinical Research Center at the Experimental and Clinical Research Center, Charité University Medicine Berlin and Max Delbrueck Center for Molecular Medicine, Berlin, Germany
    Eur J Clin Nutr 66:196-200. 2012
    ..To test the hypothesis that variations in trunk circumferences influence the accuracy of bioimpedance analysis (BIA) for assessment of percent fat mass (%FM)...
  9. ncbi request reprint Influences of AT1 receptor blockade on tissue metabolism in obese men
    Michael Boschmann
    Franz Volhard Clinical Research Center, Haus 129, Charite Campus Buch, Wiltbergstr 50, 13125 Berlin, Germany
    Am J Physiol Regul Integr Comp Physiol 290:R219-23. 2006
    ..Endogeneous ANG II may slightly increase adipose tissue lipolysis. The mechanism may promote the redistribution of triglycerides from adipose tissue toward other organs...
  10. ncbi request reprint Sympathetic vasomotor tone determines blood pressure response to long-term sibutramine treatment
    Karsten Heusser
    Franz Volhard Clinical Research Center, Medical Faculty of the Charité and HELIOS Klinikum, Berlin, Germany
    J Clin Endocrinol Metab 92:1560-3. 2007
    ..The serotonin and norepinephrine transporter inhibitor sibutramine is a widely used antiobesity drug. In acute studies, the peripheral sympathomimetic effect of sibutramine was counteracted by a central sympatholytic action...
  11. ncbi request reprint The renin-angiotensin system and natriuretic peptides in obesity-associated hypertension
    S Engeli
    Department of Nephrology and Hypertension, Franz-Volhard-Klinik, , , Berlin, Germany
    J Mol Med 79:21-9. 2001
    ..In this paper we review the role of these factors in the development of obesity-associated hypertension, thereby focusing on the potential role of adipose tissue in these alterations...
  12. ncbi request reprint The adipose-tissue renin-angiotensin-aldosterone system: role in the metabolic syndrome?
    Stefan Engeli
    HELIOS Klinikum Berlin, Franz Volhard Clinic Charité, Department of Nephrology and Hypertension, Humboldt University of Berlin, Wiltberg Strasse 50, Berlin 13125, Germany
    Int J Biochem Cell Biol 35:807-25. 2003
    ....
  13. ncbi request reprint Weight loss and the renin-angiotensin-aldosterone system
    Stefan Engeli
    Medical Faculty of the Charite, Franz Volhard Clinic and Max Delbrück Center for Molecular Medicine, HELIOS Klinikum, Berlin, Germany
    Hypertension 45:356-62. 2005
    ..These data suggest that a 5% reduction in body weight can lead to a meaningfully reduced renin-angiotensin-aldosterone system in plasma and adipose tissue, which may contribute to the reduced blood pressure...
  14. ncbi request reprint Influence of sibutramine treatment on sympathetic vasomotor tone in obese subjects
    Karsten Heusser
    Franz Volhard Clinical Research Center, Medical Faculty of the Charité and HELIOS Klinkum, Berlin, Germany
    Clin Pharmacol Ther 79:500-8. 2006
    ..Direct measurements of muscle sympathetic nerve activity (MSNA) in sibutramine-treated patients have not been conducted...
  15. doi request reprint Energy metabolism in human renin-gene transgenic rats: does renin contribute to obesity?
    Petra Gratze
    Franz Volhard Clinical Research Center, Helios Klinikum Berlin Buch, Berlin Buch, Germany
    Hypertension 53:516-23. 2009
    ..The mechanisms are independent of any currently known renin-related effects...
  16. pmc Activation of the peripheral endocannabinoid system in human obesity
    Stefan Engeli
    Franz Volhard Clinical Research Center, Charite Campus Buch, 13125 Berlin, Germany
    Diabetes 54:2838-43. 2005
    ..Our findings support the presence of a peripheral endocannabinoid system that is upregulated in human obesity...
  17. doi request reprint Comparing single-frequency bioelectrical impedance analysis against deuterium dilution to assess total body water
    V Haas
    Experimental and Clinical Research Center, a joint cooperation between Charité Universitätsmedizin and Max Delbrück Center for Molecular Medicine, Charite Universitatsmedizin, Berlin, Germany
    Eur J Clin Nutr 66:994-7. 2012
    ....
  18. ncbi request reprint Choice of drug treatment for obesity-related hypertension: where is the evidence?
    A M Sharma
    Franz Volhard Klinik, Max Delbruck Centre for Molecular Medicine, Berlin, Germany
    J Hypertens 19:667-74. 2001
    ....
  19. ncbi request reprint The effect of oral glucose loads on tissue metabolism during angiotensin II receptor and beta-receptor blockade in obese hypertensive subjects
    M Boschmann
    Franz Volhard Clinical Research Center, Charité Campus Buch and HELIOS Klinikum, Berlin, Berlin, Germany
    Horm Metab Res 38:323-9. 2006
    ..The exact mechanism by which inhibition of the renin-angiotensin-aldosterone system decreases the diabetes risk remains unresolved and requires further study...
  20. doi request reprint Dipeptidyl-peptidase-IV inhibition augments postprandial lipid mobilization and oxidation in type 2 diabetic patients
    Michael Boschmann
    Franz Volhard Clinical Research Center, Helios Klinikum and Medical Faculty of the Charité, D 13125 Berlin, Germany
    J Clin Endocrinol Metab 94:846-52. 2009
    ..Dipeptidyl-peptidase-IV (DPP-4) inhibition increases endogenous GLP-1 activity, resulting in improved glycemic control in patients with type 2 diabetes mellitus. The metabolic response may be explained in part by extrapancreatic mechanisms...
  21. ncbi request reprint Angiotensin blockade prevents type 2 diabetes by formation of fat cells
    Arya M Sharma
    HELIOS Klinikum Berlin, Franz Volhard Clinic Charité, Humboldt University of Berlin, and Max Delbruck Center for Molecular Medicine, Berlin, Germany
    Hypertension 40:609-11. 2002
    ..Increased formation of adipocytes would counteract the ectopic deposition of lipids in other tissues (muscle, liver, pancreas), thereby improving insulin sensitivity and preventing the development of type 2 diabetes...
  22. ncbi request reprint Hormonal regulation of the human adipose-tissue renin-angiotensin system: relationship to obesity and hypertension
    Kerstin Gorzelniak
    Helios Klinkum Berlin, Franz Volhard Clinic Charité and Max Delbrück Center for Molecular Medicine, Humboldt University of Berlin, Germany
    J Hypertens 20:965-73. 2002
    ..The aim of this work was to study the expression of renin-angiotensin system genes in adipose tissue of obese hypertensive subjects and the hormonal regulation of these genes...
  23. doi request reprint Circulating endocannabinoid concentrations during orthostatic stress
    Christoph Schroeder
    Franz Volhard Clinical Research Center, Helios Klinikum Berlin and Max Delbrück Center for Molecular Medicine, Berlin, Germany
    Clin Auton Res 19:343-6. 2009
    ..In animals, the endocannabinoid system is activated during hemodynamic insults and restrains blood pressure in part through sympathetic inhibition...
  24. ncbi request reprint European Society of Hypertension Working Group on Obesity: background, aims and perspectives
    Jens Jordan
    Franz Volhard Clinical Research Center and Department of Nephrology, Helios Klinikum Berlin and Medical Faculty of the Charité, Berlin, Germany
    J Hypertens 25:897-900. 2007
  25. ncbi request reprint Angiotensin type 1 receptor antagonists induce human in-vitro adipogenesis through peroxisome proliferator-activated receptor-gamma activation
    Jurgen Janke
    Medical Faculty of the Charite, Franz Volhard Clinic, HELIOS Klinikum Berlin, Berlin, Germany
    J Hypertens 24:1809-16. 2006
    ..In clonal animal cells, certain angiotensin receptor blockers (ARB) activate the peroxisome proliferator-activated receptor-gamma (PPARgamma). The aim of this work was to validate that observation in human cells and humans...
  26. pmc LMNA mutations, skeletal muscle lipid metabolism, and insulin resistance
    Michael Boschmann
    Franz Volhard Clinical Research Center at the Experimental and Clinical Research Center, University Hospital Charite Campus Buch and HELIOS Klinikum Berlin, 13125 Berlin, Germany
    J Clin Endocrinol Metab 95:1634-43. 2010
    ..The symptoms may all be explained by defective metabolism; however, metabolism at the tissue level has not been investigated...
  27. ncbi request reprint Direct Renin inhibition with aliskiren in obese patients with arterial hypertension
    Jens Jordan
    Franz Volhard Clinical Research Center, Medical Faculty of the Charité and HELIOS Klinikum, Berlin, Germany
    Hypertension 49:1047-55. 2007
    ..In conclusion, combination treatment with aliskiren is a highly effective and well-tolerated therapeutic option for obese patients with hypertension who fail to achieve blood pressure control with first-line thiazide diuretic treatment...
  28. doi request reprint Determinants of exercise-induced fat oxidation in obese women and men
    S Haufe
    Franz Volhard Clinical Research Center at the Experimental and Clinical Research Center, Charité University Medical School and Max Delbrück Center for Molecular Medicine, Berlin, Germany
    Horm Metab Res 42:215-21. 2010
    ..We conclude that in obese subjects the capacity to oxidize fat during exercise appears to be limited by skeletal muscle mass and oxidative capacity rather than the availability of visceral or intramyocellular fat...
  29. ncbi request reprint Dissociation between adipose nitric oxide synthase expression and tissue metabolism
    Stefan Engeli
    Franz Volhard Clinical Research Center, Charite Campus Buch, Wiltbergstrasse 50, 13125 Berlin, Germany
    J Clin Endocrinol Metab 92:2706-11. 2007
    ..Nitric oxide synthase (NOS) expression in adipose tissue is increased in obese subjects. The functional relevance is not known...
  30. ncbi request reprint Adipose tissue metabolism and CD11b expression on monocytes in obese hypertensives
    Michael Boschmann
    Franz Volhard Clinical Research Center, Charite Campus Buch, HELIOS Klinikum, Berlin, Germany
    Hypertension 46:130-6. 2005
    ..These findings may be explained in part by monocyte/macrophage infiltration of adipose tissue, which appears to interfere with insulin responsiveness...
  31. ncbi request reprint Regulation of the nitric oxide system in human adipose tissue
    Stefan Engeli
    HELIOS Klinikum Berlin, Franz Volhard Clinic, Charite University Medicine in Berlin, Max Delbruck Center for Molecular Medicine, Berlin, Germany
    J Lipid Res 45:1640-8. 2004
    ..Increased eNOS and iNOS expression in adipocytes and local effects of insulin and Ang II may increase adipose tissue production of NO in obesity...
  32. ncbi request reprint Regulation of 11beta-HSD genes in human adipose tissue: influence of central obesity and weight loss
    Stefan Engeli
    HELIOS Klinikum Berlin, Franz Volhard Clinic, Medical Faculty of the Charite, Humboldt University of Berlin, Berlin, Germany
    Obes Res 12:9-17. 2004
    ..The aim of this study was to determine whether up-regulation of human adipose 11beta-HSD1 in obesity can also be found at the gene expression level...
  33. ncbi request reprint Adipose tissue and circulating endothelial cell specific molecule-1 in human obesity
    J Janke
    Medical Faculty of the Charite, Franz Volhard Clinic, HELIOS Klinikum Berlin, Germany
    Horm Metab Res 38:28-33. 2006
    ..Circulating ESM-1 levels are reduced in the overweight and obese, consistent with the notion that ESM-1 may play some role in obesity-associated vascular disease...
  34. doi request reprint Genetic influences on the pharmacokinetics of orally and intravenously administered digoxin as exhibited by monozygotic twins
    A L Birkenfeld
    Experimental and Clinical Research Center, Franz Volhard Clinic, Helios Klinikum Berlin and Medical Faculty of the Charité, Berlin, Germany
    Clin Pharmacol Ther 86:605-8. 2009
    ..Our study suggests that studies involving twins could be more widely applied to elucidate pharmacogenetics...
  35. ncbi request reprint Resistin gene expression in human adipocytes is not related to insulin resistance
    Jurgen Janke
    Franz Volhard Clinic Charité, the Max Delbrück Center for Molecular Medicine, Berlin, Germany
    Obes Res 10:1-5. 2002
    ..Resistin, therefore, has been suggested to play a role in the pathogenesis of insulin resistance...
  36. ncbi request reprint Mature adipocytes inhibit in vitro differentiation of human preadipocytes via angiotensin type 1 receptors
    Jurgen Janke
    Max Delbruck Center for Molecular Medicine, HELIOS Klinikum Berlin, Franz Volhard Clinic, Medical Faculty of the Charite, Humboldt University of Berlin, Berlin, Germany
    Diabetes 51:1699-707. 2002
    ..Because AGT secretion and Ang II generation are characteristic features of adipogenesis, we postulate a paracrine negative-feedback loop that inhibits further recruitment of preadipocytes by maturing adipocytes...
  37. ncbi request reprint Association between adiponectin and mediators of inflammation in obese women
    Stefan Engeli
    HELIOS Klinikum Berlin, Franz Volhard Clinic, Medical Faculty of the Charite, Humboldt University of Berlin, Germany
    Diabetes 52:942-7. 2003
    ....
  38. ncbi request reprint Influence of salt intake on renin-angiotensin and natriuretic peptide system genes in human adipose tissue
    Stefan Engeli
    Franz Volhard Clinical Research Center, Medical Faculty of the Charité and HELIOS Klinikum, Berlin, Germany
    Hypertension 48:1103-8. 2006
    ..In contrast, systemic atrial natriuretic peptide and adipose-tissue atrial natriuretic peptide respond similarly to changes in sodium intake...
  39. ncbi request reprint Retinol-binding protein 4 in human obesity
    Jurgen Janke
    Franz Volhard Clinical Research Center Haus 129, Charite Campus Buch, Wiltbergstr 50, 13125 Berlin, Germany
    Diabetes 55:2805-10. 2006
    ..Our findings point to profound differences between rodents and humans in the regulation of adipose or circulating RBP4 and challenge the notion that glucose uptake by adipocytes has a dominant role in the regulation of RBP4...
  40. pmc Cardiorespiratory fitness and insulin sensitivity in overweight or obese subjects may be linked through intrahepatic lipid content
    Sven Haufe
    Franz Volhard Clinical Research Center at Experimental and Clinical Research Center, Charité University Medical School and Max Delbrück Center for Molecular Medicine, Berlin, Germany
    Diabetes 59:1640-7. 2010
    ..Given the close relationship between intrahepatic lipid content (IHL) and insulin sensitivity, we hypothesized that the direct relationship between fitness and insulin sensitivity may be explained by IHL...
  41. doi request reprint Influences of normobaric hypoxia training on physical fitness and metabolic risk markers in overweight to obese subjects
    Susanne Wiesner
    Franz Volhard Clinical Research Center at the Experimental and Clinical Research Center, Medical Faculty of the Charite, Berlin, Germany
    Obesity (Silver Spring) 18:116-20. 2010
    ..The fact that workload and, therefore, mechanic strain can be reduced in hypoxia could be particularly beneficial in obese patients with orthopedic comorbidities...
  42. doi request reprint Compounds used for 'injection lipolysis' destroy adipocytes and other cells found in adipose tissue
    Jurgen Janke
    Experimental and Clinical Research Center, Charite, Universitätsmedizin Berlin Campus Buch and Max Delbrück Center for Molecular Medicine, Berlin, Germany
    Obes Facts 2:36-9. 2009
    ..As the mode of action is mostly unknown, we planned to study cellular effects of the particular drug used in Germany (Lipostabil(R))...
  43. ncbi request reprint Managing big issues on lean evidence: treating obesity hypertension
    Arya M Sharma
    Nephrol Dial Transplant 17:353-5. 2002
  44. pmc Dysregulation of the peripheral and adipose tissue endocannabinoid system in human abdominal obesity
    Matthias Bluher
    University of Leipzig, Medical Department III, Philipp Rosenthal Str 27, 04103 Leipzig, Germany
    Diabetes 55:3053-60. 2006
    ..Thus, the endocannabinoid system may represent a primary target for the treatment of abdominal obesity and associated metabolic changes...
  45. ncbi request reprint Emerging concepts in the pathophysiology and treatment of obesity-associated hypertension
    Stefan Engeli
    Franz Volhard Clinic, Helios Klinikum Buch Charité, Medical Faculty of the Humboldt University Berlin, Germany
    Curr Opin Cardiol 17:355-9. 2002
    ....
  46. ncbi request reprint The role of renin-angiotensin system blockade in the management of hypertension associated with the cardiometabolic syndrome
    Arya M Sharma
    Michael G deGroote Medical School, McMaster University, Hamilton, Ontario, Canada
    J Cardiometab Syndr 1:29-35. 2006
    ..Randomized, controlled trials conducted specifically in patients with obesity and hypertension are needed to determine the optimal therapeutic approach for these patients...
  47. ncbi request reprint No evidence for an involvement of variants in the cannabinoid receptor gene (CNR1) in obesity in German children and adolescents
    Timo Dirk Müller
    Department of Child and Adolescent Psychiatry and Psychotherapy, University of Duisburg Essen, Virchowstr 174, 45147 Essen, Germany
    Mol Genet Metab 90:429-34. 2007
    ..In addition, we confirmed the presence of rs1049353. As these variants could not explain the initial TDT, we conclude that there is no evidence for an association of CNR1 alleles with obesity in our study groups...
  48. ncbi request reprint GIP receptor mRNA expression in different fat tissue depots in postmenopausal non-diabetic women
    Natalia Rudovich
    Department of Endocrinology, Diabetes and Nutrition, Campus B Franklin, Charite Medicine University of Berlin, Germany
    Regul Pept 142:138-45. 2007
    ..We identified the GIPR gene in human subcutaneous and visceral fat tissues and tested the hypothesis that that the expression of this gene is influenced by central obesity and weight loss...
  49. ncbi request reprint Does salt restriction change brown adipose tissue thermogenesis?
    Stefan Engeli
    Nutr Metab Cardiovasc Dis 16:88-90. 2006
  50. ncbi request reprint Is there a pathophysiological role for perivascular adipocytes?
    Stefan Engeli
    Am J Physiol Heart Circ Physiol 289:H1794-5. 2005