Affiliation: Humboldt University
Langer S, Kreutz R, Eisenreich A. Metformin modulates apoptosis and cell signaling of human podocytes under high glucose conditions. J Nephrol. 2016;29:765-773 pubmed
..In summary, metformin exhibits an anti-apoptotic impact on podocytes under high-glucose conditions via activation of AMPK and inhibition of mTOR signaling. These data support a beneficial effect of metformin in diabetic nephropathy. ..
Eisenreich A, Bolbrinker J, Leppert U. Tissue Factor: A Conventional or Alternative Target in Cancer Therapy. Clin Chem. 2016;62:563-70 pubmed publisher
..e., in thrombogenicity and angiogenesis, which is mediated by isoform-specific signal transduction pathways. Therefore, both TF isoforms and downstream signaling are promising novel therapeutic targets in malignant diseases. ..
Eisenreich A, Malz R, Pepke W, Ayral Y, Poller W, Schultheiss H, et al
. Role of the phosphatidylinositol 3-kinase/protein kinase B pathway in regulating alternative splicing of tissue factor mRNA in human endothelial cells. Circ J. 2009;73:1746-52 pubmed
..Additionally, overexpression of SF2/ASF and SRp75 influenced the differential TF-isoform expression in HUVECs. The PI3K/Akt pathway modulates alternative splicing of TF in HUVECs, distinct from transcriptional regulation. ..
Eisenreich A, Zakrzewicz A, Huber K, Thierbach H, Pepke W, Goldin Lang P, et al
. Regulation of pro-angiogenic tissue factor expression in hypoxia-induced human lung cancer cells. Oncol Rep. 2013;30:462-70 pubmed publisher
..Taken together, our results suggest that the pro-angiogenic potential of A549 lung cancer cells is modulated under hypoxic conditions via modulation of TF isoform expression which in turn is controlled by alternative splicing. ..
Leppert U, Gillespie A, Orphal M, BÃ¶hme K, Plum C, Nagorsen K, et al
. The impact of Î±-Lipoic acid on cell viability and expression of nephrin and ZNF580 in normal human podocytes. Eur J Pharmacol. 2017;810:1-8 pubmed publisher
..These data provide first novel information about potential cytotoxic effects of Î±-LA on hPC under non-diabetic conditions. ..