J P Dreier

Summary

Affiliation: Humboldt University
Country: Germany

Publications

  1. ncbi request reprint Products of hemolysis in the subarachnoid space inducing spreading ischemia in the cortex and focal necrosis in rats: a model for delayed ischemic neurological deficits after subarachnoid hemorrhage?
    J P Dreier
    Department of Neurology and Physiology, Charite, Humboldt University, Berlin, Germany
    J Neurosurg 93:658-66. 2000
  2. ncbi request reprint Delayed ischaemic neurological deficits after subarachnoid haemorrhage are associated with clusters of spreading depolarizations
    Jens P Dreier
    Department of Experimental Neurology and Neurology, Charite University Medicine, Berlin, Germany
    Brain 129:3224-37. 2006
  3. ncbi request reprint Endothelin-1-induced spreading depression in rats is associated with a microarea of selective neuronal necrosis
    Jens P Dreier
    Department of Experimental Neurology, Charite Universitatsmedizin, Berlin, Berlin, Germany
    Exp Biol Med (Maywood) 232:204-13. 2007
  4. ncbi request reprint Cortical spreading depression: an adverse but treatable factor in intensive care?
    Anthony J Strong
    King s College London, Department of Clinical Neurosciences, London, UK
    Curr Opin Crit Care 13:126-33. 2007
  5. ncbi request reprint Migraine and delayed ischaemic neurological deficit after subarachnoid haemorrhage in women: a case-control study
    J P Dreier
    Department of Neurology, Charite University Medicine Berlin, Germany
    Eur J Neurol 14:1363-8. 2007
  6. pmc Is spreading depolarization characterized by an abrupt, massive release of gibbs free energy from the human brain cortex?
    Jens P Dreier
    Center for Stroke Research Berlin, Charite University Medicine Berlin, Berlin, Germany
    Neuroscientist 19:25-42. 2013
  7. doi request reprint Electrochemical failure of the brain cortex is more deleterious when it is accompanied by low perfusion
    Jens P Dreier
    Center for Stroke Research Berlin, Charite University Medicine Berlin, Chariteplatz 1, 10117 Berlin, Germany
    Stroke 44:490-6. 2013
  8. doi request reprint Spreading ischemia after aneurysmal subarachnoid hemorrhage
    Jens P Dreier
    Charite University Medicine Berlin, Chariteplatz 1, Berlin, Germany
    Acta Neurochir Suppl 115:125-9. 2013
  9. pmc Spreading convulsions, spreading depolarization and epileptogenesis in human cerebral cortex
    Jens P Dreier
    Centre for Stroke Research Berlin, Charite University Medicine Berlin, 10117 Berlin, Germany
    Brain 135:259-75. 2012
  10. ncbi request reprint Statin-associated rhabdomyolysis triggered by grapefruit consumption
    Jens P Dreier
    Department of Neurology, Charite Hospital, University Medicine Berlin, Germany
    Neurology 62:670. 2004

Collaborators

Detail Information

Publications46

  1. ncbi request reprint Products of hemolysis in the subarachnoid space inducing spreading ischemia in the cortex and focal necrosis in rats: a model for delayed ischemic neurological deficits after subarachnoid hemorrhage?
    J P Dreier
    Department of Neurology and Physiology, Charite, Humboldt University, Berlin, Germany
    J Neurosurg 93:658-66. 2000
    ..The purpose of the present study was to investigate whether such spreading ischemias in the cortex lead to brain damage...
  2. ncbi request reprint Delayed ischaemic neurological deficits after subarachnoid haemorrhage are associated with clusters of spreading depolarizations
    Jens P Dreier
    Department of Experimental Neurology and Neurology, Charite University Medicine, Berlin, Germany
    Brain 129:3224-37. 2006
    ..In view of experimental evidence and the present clinical results, we suggest that spreading depolarizations with prolonged depressions are a promising target for treatment development in SAH and ischaemic stroke...
  3. ncbi request reprint Endothelin-1-induced spreading depression in rats is associated with a microarea of selective neuronal necrosis
    Jens P Dreier
    Department of Experimental Neurology, Charite Universitatsmedizin, Berlin, Berlin, Germany
    Exp Biol Med (Maywood) 232:204-13. 2007
    ..In conclusion, SD in presence of ET-1 induced a microarea of selective neuronal necrosis no matter where the SD originated. This effect of ET-1 appears to be mediated by the ET(A) receptor...
  4. ncbi request reprint Cortical spreading depression: an adverse but treatable factor in intensive care?
    Anthony J Strong
    King s College London, Department of Clinical Neurosciences, London, UK
    Curr Opin Crit Care 13:126-33. 2007
    ....
  5. ncbi request reprint Migraine and delayed ischaemic neurological deficit after subarachnoid haemorrhage in women: a case-control study
    J P Dreier
    Department of Neurology, Charite University Medicine Berlin, Germany
    Eur J Neurol 14:1363-8. 2007
    ..99-7.29). Migraineurs revealed similar prevalences of risk factors independently of the presence of DINDs. This retrospective study suggests that women with migraine have a higher risk to develop a DIND than women without migraine...
  6. pmc Is spreading depolarization characterized by an abrupt, massive release of gibbs free energy from the human brain cortex?
    Jens P Dreier
    Center for Stroke Research Berlin, Charite University Medicine Berlin, Berlin, Germany
    Neuroscientist 19:25-42. 2013
    ....
  7. doi request reprint Electrochemical failure of the brain cortex is more deleterious when it is accompanied by low perfusion
    Jens P Dreier
    Center for Stroke Research Berlin, Charite University Medicine Berlin, Chariteplatz 1, 10117 Berlin, Germany
    Stroke 44:490-6. 2013
    ..We here investigated whether this commitment point is shifted to an earlier period, when spreading depolarization is accompanied by a perfusion deficit...
  8. doi request reprint Spreading ischemia after aneurysmal subarachnoid hemorrhage
    Jens P Dreier
    Charite University Medicine Berlin, Chariteplatz 1, Berlin, Germany
    Acta Neurochir Suppl 115:125-9. 2013
    ..In patients, spreading ischemia occurred in temporal correlation with ischemic lesion development early and late after aSAH. We briefly review important features of SD and spreading ischemia following aSAH...
  9. pmc Spreading convulsions, spreading depolarization and epileptogenesis in human cerebral cortex
    Jens P Dreier
    Centre for Stroke Research Berlin, Charite University Medicine Berlin, 10117 Berlin, Germany
    Brain 135:259-75. 2012
    ..Hence, practically all major pathological cortical network events in animals have now been observed in people. Early spreading depolarizations may indicate a risk for late post-haemorrhagic seizures...
  10. ncbi request reprint Statin-associated rhabdomyolysis triggered by grapefruit consumption
    Jens P Dreier
    Department of Neurology, Charite Hospital, University Medicine Berlin, Germany
    Neurology 62:670. 2004
  11. ncbi request reprint Delayed occlusion after internal carotid artery dissection under heparin
    Jens P Dreier
    Department of Neurology, Campus Mitte, Charité University of Medicine Berlin, Berlin, Germany
    Cerebrovasc Dis 18:296-303. 2004
    ..Our findings further justify a randomized clinical trial to resolve the anticoagulant/antiplatelet debate...
  12. pmc Cortical spreading ischaemia is a novel process involved in ischaemic damage in patients with aneurysmal subarachnoid haemorrhage
    Jens P Dreier
    Department of Experimental Neurology, Charite University Medicine Berlin, Berlin, Germany
    Brain 132:1866-81. 2009
    ....
  13. ncbi request reprint Opening of the blood-brain barrier preceding cortical edema in a severe attack of FHM type II
    J P Dreier
    Department of Neurology, Charite University Medicine, 10117 Berlin, Germany
    Neurology 64:2145-7. 2005
    ..The findings suggest that the delayed cortical edema was vasogenic in the severe migraine aura variant of this ATP1A2 mutation carrier...
  14. ncbi request reprint Partial antagonistic effect of adenosine on inverse coupling between spreading neuronal activation and cerebral blood flow in rats
    Jens P Dreier
    Department of Experimental Neurology, Charite, University Medicine Berlin, and Psychiatry, Wenckebach Hospital, Berlin, Germany
    Neurocrit Care 1:85-94. 2004
    ..Adenosine is one of the classical candidate factors to mediate the coupling between neuronal metabolism and CBF. Therefore, the effect of topically applied adenosine on cortical spreading ischemia was studied...
  15. doi request reprint The role of spreading depression, spreading depolarization and spreading ischemia in neurological disease
    Jens P Dreier
    Center for Stroke Research, Department of Experimental Neurology and Neurology, Charite University Medicine Berlin, Berlin, Germany
    Nat Med 17:439-47. 2011
    ..Therapies that target spreading depolarization or the inverse hemodynamic response may potentially treat these neurological conditions...
  16. ncbi request reprint Focal laminar cortical MR signal abnormalities after subarachnoid hemorrhage
    Jens P Dreier
    Department of Neurology, Charite Hospital Standort Mitte, Humboldt University, Schumannstrasse 20 21, 10117 Berlin, Germany
    Ann Neurol 52:825-9. 2002
    ..This magnetic resonance imaging pattern may provide a clue to the diagnosis if the patient does not present to the emergency room with the acute hemorrhage but with delayed ischemic neurological deficits...
  17. ncbi request reprint Ischemia triggered by red blood cell products in the subarachnoid space is inhibited by nimodipine administration or moderate volume expansion/hemodilution in rats
    Jens P Dreier
    Department of Neurology and Experimental Neurology, Charite Hospital, Humboldt University, Berlin, Germany
    Neurosurgery 51:1457-65; discussion 1465-7. 2002
    ..To gain insight into the underlying mechanism, we studied the effects of nimodipine or volume expansion on ischemic events induced by RBC products in rats...
  18. ncbi request reprint Endothelin-1 potently induces Leão's cortical spreading depression in vivo in the rat: a model for an endothelial trigger of migrainous aura?
    Jens P Dreier
    Department of Experimental Neurology, Charite, Humboldt University, Berlin, Germany
    Brain 125:102-12. 2002
    ..In conclusion, endothelin-1 was found in the experiment to be the most potent inducer of CSD currently known. We propose endothelin-1 as a possible candidate for the yet enigmatic link between endothelial irritation and migrainous aura...
  19. pmc Ischaemia triggered by spreading neuronal activation is inhibited by vasodilators in rats
    J P Dreier
    Department of Experimental Neurology, Humboldt University, Berlin, Germany
    J Physiol 531:515-26. 2001
    ..Speculatively, this pathogenetic process could be involved in migraine-induced stroke...
  20. ncbi request reprint Nitric oxide from perivascular nerves modulates cerebral arterial pH reactivity
    U Lindauer
    Department of Experimental Neurology, Humboldt University, Charite Hospital, 10098 Berlin, Germany
    Am J Physiol Heart Circ Physiol 281:H1353-63. 2001
    ..0 (denervated: 49 +/- 31 microm). Removal of the endothelium did not change vasodilation to acidosis. We conclude that NO, produced by neuronal NOS of perivascular nerves, is a modulator in the pH-dependent vasoreactivity...
  21. ncbi request reprint The cerebrovascular response to elevated potassium--role of nitric oxide in the in vitro model of isolated rat middle cerebral arteries
    S Schuh-Hofer
    Department of Experimental Neurology, Humboldt University, , 10098, Berlin, Germany
    Neurosci Lett 306:61-4. 2001
    ..Our findings together with findings from the literature indicate a modulator role of NO at K(+) > or = 40 mM K(+), involving a cGMP-dependent mechanism...
  22. doi request reprint Blood-brain barrier opening to large molecules does not imply blood-brain barrier opening to small ions
    E J Kang
    Department of Experimental Neurology, Charite Universitatsmedizin, 10117 Berlin, Germany
    Neurobiol Dis 52:204-18. 2013
    ....
  23. pmc Peri-infarct blood-brain barrier dysfunction facilitates induction of spreading depolarization associated with epileptiform discharges
    E G Lapilover
    Institute of Neurophysiology, Neurocure Research Center, Center for Stroke Research Berlin, Charite Universitatsmedizin, 13347 Berlin, Germany
    Neurobiol Dis 48:495-506. 2012
    ..We suggest that BBB opening facilitates the induction of peri-infarct SDs through impaired homeostasis of K+...
  24. doi request reprint Spreading depolarizations occur in human ischemic stroke with high incidence
    Christian Dohmen
    Department of Neurology, University of Cologne, Cologne, Germany
    Ann Neurol 63:720-8. 2008
    ..For decades it has been questioned whether CSD or PID occur in human ischemic stroke. Here, we describe CSD and PID in patients with malignant middle cerebral artery infarction detected by subdural electrocorticography (ECoG)...
  25. doi request reprint Nitric oxide modulates spreading depolarization threshold in the human and rodent cortex
    Gabor C Petzold
    Department of Experimental Neurology, Charite University Medicine Berlin, Berlin, Germany
    Stroke 39:1292-9. 2008
    ..We investigated whether a similar extracellular composition renders the brain more susceptible to CSDs...
  26. ncbi request reprint Relation of cerebral energy metabolism and extracellular nitrite and nitrate concentrations in patients after aneurysmal subarachnoid hemorrhage
    O W Sakowitz
    Department of Neurosurgery, , Berlin, Germany
    J Cereb Blood Flow Metab 21:1067-76. 2001
    ..On the basis of the current findings, however, subsequent development of DIND cannot be explained by a lack of vasodilatory NO alone...
  27. ncbi request reprint Impaired cerebrovascular reactivity after cortical spreading depression in rats: Restoration by nitric oxide or cGMP
    Klaus Ernst Ludwig Scheckenbach
    Department of Experimental Neurology, Charite Universitatsmedizin Berlin, 10098 Berlin, Germany
    Exp Neurol 202:449-55. 2006
    ....
  28. pmc Experimental and preliminary clinical evidence of an ischemic zone with prolonged negative DC shifts surrounded by a normally perfused tissue belt with persistent electrocorticographic depression
    Ana I Oliveira-Ferreira
    Department of Experimental Neurology, Charite University Medicine Berlin, Berlin, Germany
    J Cereb Blood Flow Metab 30:1504-19. 2010
    ..These preliminary results suggest that the ischemic zone in rat and human cortex is surrounded by a normally perfused belt with persistently reduced synaptic activity during the acute injury phase...
  29. ncbi request reprint Ion changes in spreading ischaemia induce rat middle cerebral artery constriction in the absence of NO
    Olaf Windmüller
    Department of Neurology, Charite University Medicine, 10117 Berlin, Germany
    Brain 128:2042-51. 2005
    ..In the presence of NO they mediate vasodilatation and in its absence they mediate constriction...
  30. ncbi request reprint Increased extracellular K+ concentration reduces the efficacy of N-methyl-D-aspartate receptor antagonists to block spreading depression-like depolarizations and spreading ischemia
    Gabor C Petzold
    Department of Neurology, Charite University Medicine Berlin, Berlin, Germany
    Stroke 36:1270-7. 2005
    ..However, because both SD-like depolarizations and SI occur in presence of an increased extracellular K+ concentration ([K+]o), we tested whether this increase in baseline [K+]o would reduce the efficacy of NMDAR antagonists...
  31. doi request reprint The gamut of blood flow responses coupled to spreading depolarization in rat and human brain: from hyperemia to prolonged ischemia
    N Offenhauser
    Center for Stroke Research Berlin, Department of Experimental Neurology, Charite University Medicine Berlin, Berlin, Germany
    Acta Neurochir Suppl 110:119-24. 2011
    ..The correspondence of the rCBF response spectrum to SD between human and animal brain underscores the importance of animal models to learn more about the mechanisms underlying the early and delayed pathological sequelae of SAH...
  32. ncbi request reprint Cluster-like headache time-locked to the menstrual cycle
    Gabor C Petzold
    Department of Neurology, Charite Hospital, Humboldt University, Berlin, Germany
    Neurology 60:1049. 2003
  33. ncbi request reprint Cerebrovascular vasodilation to extraluminal acidosis occurs via combined activation of ATP-sensitive and Ca2+-activated potassium channels
    Ute Lindauer
    Experimental Neurology, Charite, Humboldt Universitat, Berlin, Germany
    J Cereb Blood Flow Metab 23:1227-38. 2003
    ....
  34. ncbi request reprint Ischemia triggered by spreading neuronal activation is induced by endothelin-1 and hemoglobin in the subarachnoid space
    Gabor C Petzold
    Departments of Experimental Neurology, Charite Hospital, Humboldt University, Schumannstrasse 20 21, 10098 Berlin, Germany
    Ann Neurol 54:591-8. 2003
    ..The results may have implications for the understanding of subarachnoid hemorrhage-related cortical lesions...
  35. doi request reprint Recurrent stroke due to a novel voltage sensor mutation in Cav2.1 responds to verapamil
    Ellen Knierim
    Department of Neuropediatrics, Charite Universitatsmedizin Berlin, D 13353 Berlin, Germany
    Stroke 42:e14-7. 2011
    ..Treatment was instantly effective and prevented a new stroke...
  36. pmc A novel algorithm for the assessment of blood-brain barrier permeability suggests that brain topical application of endothelin-1 does not cause early opening of the barrier in rats
    D Jorks
    Department of Experimental Neurology, Charite University Medicine Berlin, 10098 Berlin, Germany
    Cardiovasc Psychiatry Neurol 2011:169580. 2011
    ..The algorithm can be used, for example, to assess BBB permeability ex vivo in combination with dynamic in vivo studies of BBB opening...
  37. ncbi request reprint ET-1 induces cortical spreading depression via activation of the ETA receptor/phospholipase C pathway in vivo
    Jörg Kleeberg
    Department of Neurology, Humboldt Universitat, 10117 Berlin, Germany
    Am J Physiol Heart Circ Physiol 286:H1339-46. 2004
    ..On the basis of the receptor profile, likely primary targets of ET-1 mediating CSD are either neurons or vascular smooth muscle cells...
  38. doi request reprint Endothelin-1(1-31) induces spreading depolarization in rats
    D Jorks
    Department of Experimental Neurology, Charite University Medicine Berlin, Berlin, Germany
    Acta Neurochir Suppl 110:111-7. 2011
    ..ET-1(1-31) is an alternate metabolic intermediate in the generation of ET-1. Our aim was to investigate whether endothelin-1(1-31) causes SD in a similar fashion to ET-1...
  39. ncbi request reprint Clearance of a status aurae migraenalis in response to thrombendarterectomy in a patient with high grade internal carotid artery stenosis
    R Klingebiel
    Department of Neurology, Charite, University Medicine Berlin, Schumannstr 20 21, 10098 Berlin, Germany
    J Neurol Neurosurg Psychiatry 79:89-90. 2008
    ..Importantly, after ICA thrombendarterectomy, the status aurae migraenalis abruptly ceased which supports the concept that high grade ICA stenosis can be the cause of status aurae migraenalis...
  40. ncbi request reprint Valproic acid is effective in migraine prophylaxis at low serum levels: a prospective open-label study
    S Kinze
    Department of Neurology, , Humboldt University of Berlin, Germany
    Headache 41:774-8. 2001
    ....
  41. doi request reprint Intraoperative monitoring of cerebral blood flow by laser speckle contrast analysis
    Nils Hecht
    Department of Neurosurgery, Charite Universitatsmedizin Berlin, Berlin, Germany
    Neurosurg Focus 27:E11. 2009
    ..The purpose of this preliminary study was to address the general feasibility of LASCA in terms of handling and image quality and to provide an example of its clinical implications...
  42. ncbi request reprint Lasting blood-brain barrier disruption induces epileptic focus in the rat somatosensory cortex
    Ernst Seiffert
    Johannes Muller Institute of Physiology, Charite, University Medicine, 10117 Berlin, Germany
    J Neurosci 24:7829-36. 2004
    ..Although many neuropathologies entail a compromised blood-brain barrier, this is the first direct evidence that it may have a role in the pathogenesis of focal cortical epilepsy, a common neurological disease...
  43. doi request reprint Chronically epileptic human and rat neocortex display a similar resistance against spreading depolarization in vitro
    Anna Maslarova
    Institute of Neurophysiology, Center for Stroke Research Berlin, Department of Experimental Neurology, Charite University Medicine Berlin, Chariteplatz 1, 10117 Berlin, Germany
    Stroke 42:2917-22. 2011
    ..However, network changes associated with epilepsy may interfere with tissue susceptibility to SD. This could distort the results of pharmacological tests...
  44. ncbi request reprint Nitric oxide modulates calcium entry through P/Q-type calcium channels and N-methyl-d-aspartate receptors in rat cortical neurons
    Gabor C Petzold
    Department of Experimental Neurology, Charite University Medicine Berlin, Schumannstr 20 21, 10117 Berlin, Germany
    Brain Res 1063:9-14. 2005
    ..These results suggest that NO can modulate neuronal calcium entry during depolarization by interacting with P/Q-type VGCC and NMDAR...
  45. ncbi request reprint Migraine-induced stroke in a patient with migraine-related epilepsy
    Gabor C Petzold
    Headache 43:694-6. 2003
  46. pmc Association of seizures with cortical spreading depression and peri-infarct depolarisations in the acutely injured human brain
    Martin Fabricius
    Department of Clinical Neurophysiology, Glostrup Hospital, Nordre Ringvej, 2600 Glostrup, Denmark
    Clin Neurophysiol 119:1973-84. 2008
    ....