D Dragun

Summary

Affiliation: Humboldt University
Country: Germany

Publications

  1. ncbi request reprint Novelties in diagnostics and therapy of antibody mediated rejection
    Duska Dragun
    Department of Nephrology and Intensive Care Medicine, Charite Campus Virchow Clinic, Augustenburger Platz 1, 13353 Berlin, Germany
    Nephrol Dial Transplant 22:viii50-viii53. 2007
  2. doi request reprint Humoral responses directed against non-human leukocyte antigens in solid-organ transplantation
    Duska Dragun
    Department of Nephrology and Intensive Care Medicine, Campus Virchow Klinikum, Berlin, Germany
    Transplantation 86:1019-25. 2008
  3. doi request reprint Non-HLA antibodies in solid organ transplantation: recent concepts and clinical relevance
    Duska Dragun
    Clinic for Nephrology and Intensive Care Medicine Campus Virchow Klinikum and Center for Cardiovascular Research, Medical Faculty of the Charite, Berlin, Germany
    Curr Opin Organ Transplant 18:430-5. 2013
  4. doi request reprint Sex-specific mTOR signaling determines sexual dimorphism in myocardial adaptation in normotensive DOCA-salt model
    Dennis Gürgen
    Department of Nephrology and Intensive Care Medicine, Charite Universitatsmedizin Berlin, Berlin, Germany
    Hypertension 61:730-6. 2013
  5. doi request reprint Non-HLA-antibodies targeting Angiotensin type 1 receptor and antibody mediated rejection
    Duska Dragun
    Clinic for Nephrology and Intensive Care Medicine, Campus Virchow Klinikum and Center for Cardiovascular Research, Medical Faculty of the Charite, Berlin, Germany
    Hum Immunol 73:1282-6. 2012
  6. doi request reprint Role of non-HLA antibodies in organ transplantation
    Duska Dragun
    Clinic for Nephrology and Intensive Care Medicine, Campus Virchow Klinikum and Center for Cardiovascular Research, Medical Faculty of the Charité Berlin, Berlin, Germany
    Curr Opin Organ Transplant 17:440-5. 2012
  7. ncbi request reprint Angiotensin II type 1-receptor activating antibodies in renal-allograft rejection
    Duska Dragun
    Department of Nephrology, Charite University Hospital, Berlin, Germany
    N Engl J Med 352:558-69. 2005
  8. ncbi request reprint Complement-ary matching: A definite maybe
    Duska Dragun
    Department of Nephrology and Center for Cardiovascular Research, Charite University Medicine Berlin, Berlin, Germany
    Nephrol Dial Transplant 21:3371-3. 2006
  9. ncbi request reprint Autoimmune mediated G-protein receptor activation in cardiovascular and renal pathologies
    Duska Dragun
    Department of Nephrology and Intensive Care Medicine, Charite Campus Virchow Clinic, Berlin, Germany
    Thromb Haemost 101:643-8. 2009
  10. doi request reprint Non-HLA antibodies post-transplantation: clinical relevance and treatment in solid organ transplantation
    Duska Dragun
    Department of Nephrology and Intensive Care Medicine, Charite Campus Virchow Clinic, Augustenburger Platz 1, D 13353 Berlin, Germany
    Contrib Nephrol 162:129-39. 2009

Detail Information

Publications50

  1. ncbi request reprint Novelties in diagnostics and therapy of antibody mediated rejection
    Duska Dragun
    Department of Nephrology and Intensive Care Medicine, Charite Campus Virchow Clinic, Augustenburger Platz 1, 13353 Berlin, Germany
    Nephrol Dial Transplant 22:viii50-viii53. 2007
    ..The analysis of the subtle mechanistic and diagnostic differences among rejection subtypes will help to identify patients at particular risk and improve outcome of AMR...
  2. doi request reprint Humoral responses directed against non-human leukocyte antigens in solid-organ transplantation
    Duska Dragun
    Department of Nephrology and Intensive Care Medicine, Campus Virchow Klinikum, Berlin, Germany
    Transplantation 86:1019-25. 2008
    ....
  3. doi request reprint Non-HLA antibodies in solid organ transplantation: recent concepts and clinical relevance
    Duska Dragun
    Clinic for Nephrology and Intensive Care Medicine Campus Virchow Klinikum and Center for Cardiovascular Research, Medical Faculty of the Charite, Berlin, Germany
    Curr Opin Organ Transplant 18:430-5. 2013
    ..A conceptual framework on the role of graft microenvironment during initiation of non-HLA-related humoral immunity is addressed as well...
  4. doi request reprint Sex-specific mTOR signaling determines sexual dimorphism in myocardial adaptation in normotensive DOCA-salt model
    Dennis Gürgen
    Department of Nephrology and Intensive Care Medicine, Charite Universitatsmedizin Berlin, Berlin, Germany
    Hypertension 61:730-6. 2013
    ..Maintenance of both mTORC1 and mTORC2 signaling seems to be essential for adaptive cardiac remodeling in females and supports a rationale for sex-specific therapeutic strategies in left ventricular hypertrophy...
  5. doi request reprint Non-HLA-antibodies targeting Angiotensin type 1 receptor and antibody mediated rejection
    Duska Dragun
    Clinic for Nephrology and Intensive Care Medicine, Campus Virchow Klinikum and Center for Cardiovascular Research, Medical Faculty of the Charite, Berlin, Germany
    Hum Immunol 73:1282-6. 2012
    ..This review summarizes the current state of research in AT(1)R biology, development in diagnostic strategies, discusses recent clinical studies, and provides perspectives on further refinements in understanding AT(1)R-Ab-actions...
  6. doi request reprint Role of non-HLA antibodies in organ transplantation
    Duska Dragun
    Clinic for Nephrology and Intensive Care Medicine, Campus Virchow Klinikum and Center for Cardiovascular Research, Medical Faculty of the Charité Berlin, Berlin, Germany
    Curr Opin Organ Transplant 17:440-5. 2012
    ..We aimed to summarize the data on discovery of new antigenic targets, novel experimental findings, recent diagnostic developments, and introduction of new technologies in the field of non-HLA antigens in solid organ transplantation...
  7. ncbi request reprint Angiotensin II type 1-receptor activating antibodies in renal-allograft rejection
    Duska Dragun
    Department of Nephrology, Charite University Hospital, Berlin, Germany
    N Engl J Med 352:558-69. 2005
    ..Antibodies against HLA antigens cause refractory allograft rejection with vasculopathy in some, but not all, patients...
  8. ncbi request reprint Complement-ary matching: A definite maybe
    Duska Dragun
    Department of Nephrology and Center for Cardiovascular Research, Charite University Medicine Berlin, Berlin, Germany
    Nephrol Dial Transplant 21:3371-3. 2006
  9. ncbi request reprint Autoimmune mediated G-protein receptor activation in cardiovascular and renal pathologies
    Duska Dragun
    Department of Nephrology and Intensive Care Medicine, Charite Campus Virchow Clinic, Berlin, Germany
    Thromb Haemost 101:643-8. 2009
    ..In terms of targets we will focus on the alpha-adrenergic receptor (alpha(1)AR), the beta-adrenergic receptor (beta(1)AR), and the angiotensin II type 1 receptor (AT(1)R)...
  10. doi request reprint Non-HLA antibodies post-transplantation: clinical relevance and treatment in solid organ transplantation
    Duska Dragun
    Department of Nephrology and Intensive Care Medicine, Charite Campus Virchow Clinic, Augustenburger Platz 1, D 13353 Berlin, Germany
    Contrib Nephrol 162:129-39. 2009
    ....
  11. ncbi request reprint FTY720-induced lymphocyte homing modulates post-transplant preservation/reperfusion injury
    Duska Dragun
    Department of Nephrology, Medical Faculty of the Charité Campus Mitte, Berlin, Germany
    Kidney Int 65:1076-83. 2004
    ..We tested whether or not single-dose FTY720 (0.5 mg/kg) pretreatment rescues renal grafts from post-transplant preservation/reperfusion injury...
  12. ncbi request reprint Patients with steroid refractory acute vascular rejection develop agonistic antibodies targeting angiotensin II type 1 receptor
    D Dragun
    Department of Nephrology Medical Faculty of the Charité Campi Mitte, Berlin, Germany
    Transplant Proc 35:2104-5. 2003
  13. ncbi request reprint Prolonged cold preservation augments vascular injury independent of renal transplant immunogenicity and function
    D Dragun
    , , Humboldt University, Berlin, Germany
    Kidney Int 60:1173-81. 2001
    ..CONCLUSIONS: Because of the prominent vascular injury, strategies for endothelial protection should be attempted in grafts with long preservation times in clinical renal transplantation...
  14. ncbi request reprint FTY720: early clinical experience
    D Dragun
    University Hospital Charite, Department of Nephrology, Campus Mitte, Berlin, Germany
    Transplant Proc 36:544S-548S. 2004
    ....
  15. ncbi request reprint Enteric-coated mycophenolate sodium: safe conversion from mycophenolate mofetil in maintenance renal transplant recipients
    K Budde
    University Hospital Charite, Berlin, Germany
    Transplant Proc 36:524S-527S. 2004
    ..5% vs MMF: 12.3%; P=ns). These data demonstrate that stable renal transplant recipients receiving MMF can be converted to EC-MPS with no efficacy or tolerability compromise...
  16. ncbi request reprint Differences in reporting of acute rejections between American and European publications of large immunosuppressive trials impair comparability of study results
    F Fleiner
    Department of Nephrology, University Hospital Charite, Campus Mitte, Schumannstrasse 20 21, 10098 Berlin, Germany
    Transplant Proc 37:2048-50. 2005
    ..5% vs E: 26.5%). Our systematic review showed large discrepancies with a trend to report biopsy-proven rejection rates only in recent years...
  17. ncbi request reprint [Clinical risk-adapted therapies in systemic sclerosis]
    G Riemekasten
    Medizinische Klinik mit Schwerpunkt Rheumatologie und Klinische Immunologie der Charité Universitätsmedizin, Centrum 12, Charite Campus Mitte, Chariteplatz 1, 10117, Berlin, Germany
    Z Rheumatol 66:672-4, 676-8. 2007
    ..The paper also highlights possible future treatment options, including vasoactive, cellular and immune suppressant treatments...
  18. doi request reprint Cytoprotective Actions of FTY720 Modulate Severe Preservation Reperfusion Injury in Rat Renal Transplants
    T Florian Fuller
    Department of Urology, Charite Universitaetsmedizin Berlin, Berlin, Germany
    Transplantation 89:402-8. 2010
    ..The purpose of this study was to explore the role of FTY720 in ischemic injury and regeneration using a clinically relevant rat renal transplant model with 24 hr of cold ischemia...
  19. ncbi request reprint Effect of mycophenolate mofetil on rat kidney grafts with prolonged cold preservation
    T F Fuller
    Department of Urology, Charité Universitaetsmedizin Berlin Campus Mitte, Berlin, Germany
    Kidney Int 70:570-7. 2006
    ..In grafts with severe preservation injury (39 h c.s.), MMF caused irreversible structural damage and inhibited tubular cell regeneration resulting in renal failure...
  20. ncbi request reprint Impact of cyclosporine on the development of immunosuppressive therapy
    L Fritsche
    Department of Nephrology, Charite Campus Mitte, Berlin, Germany
    Transplant Proc 36:130S-134S. 2004
    ..With other trials evaluating the impact of Neoral in combination with newer therapies such as Certican, myfortic, and FTY720, the use of CsA in transplant recipients looks set to continue...
  21. ncbi request reprint Laparoscopic versus open donor nephrectomy in Germany: impact on donor health-related quality of life and willingness to donate
    M Giessing
    Department of Urology, Charité University Hospital CCM of Humboldt University Berlin, Schumannstrasse 20 21, D 10098 Berlin, Germany
    Transplant Proc 37:2011-5. 2005
    ..We therefore performed a study with two questionnaires (SF-36/GBB-24) and one set of open questions for all donors in our department...
  22. ncbi request reprint [Urological evaluation and follow-up of the kidney transplant patient]
    T F Fuller
    Klinik für Urologie, Campus Mitte, Charite, Universitatsmedizin, Schumannstrasse 20 21, 10017 Berlin
    Urologe A 45:53-9. 2006
    ..For the evaluation and follow-up of the living kidney donor, international guidelines have been developed in recent years to also help the urologist to perform a correct evaluation and follow-up of the kidney donor...
  23. pmc Increased incidence of angioedema with ACE inhibitors in combination with mTOR inhibitors in kidney transplant recipients
    Michael Duerr
    Department of Nephrology, Charite Universitatsmedizin Berlin, Chariteplatz 1, 10117 Berlin, Germany
    Clin J Am Soc Nephrol 5:703-8. 2010
    ..Hereditary defects, drugs, and food allergies may play a role in the development of angioedema. We systematically investigated the incidence of angioedema in renal allograft recipients treated with mTOR inhibitors (mTORis)...
  24. doi request reprint A comparison of the RIFLE and Acute Kidney Injury Network classifications for cardiac surgery-associated acute kidney injury: a prospective cohort study
    Michael Haase
    Department of Intensive Care, Austin Health, Melbourne, Australia
    J Thorac Cardiovasc Surg 138:1370-6. 2009
    ..In this study we compared these classifications with regard to (1) the detection of acute kidney injury, (2) their agreement according to the grading of acute kidney injury across classes, and (3) their prognostic value...
  25. doi request reprint Accuracy of neutrophil gelatinase-associated lipocalin (NGAL) in diagnosis and prognosis in acute kidney injury: a systematic review and meta-analysis
    Michael Haase
    Department of Nephrology and Intensive Care Medicine, Charite University Medicine, Berlin, Germany
    Am J Kidney Dis 54:1012-24. 2009
    ..Neutrophil gelatinase-associated lipocalin (NGAL) appears to be a promising biomarker for the early diagnosis of acute kidney injury (AKI); however, a wide range in its predictive value has been reported...
  26. ncbi request reprint A systematic approach to managing pregnant dialysis patients--the importance of an intensified haemodiafiltration protocol
    Michael Haase
    Departments of Nephrology, Charité University Hospital CCM, Berlin, Germany
    Nephrol Dial Transplant 20:2537-42. 2005
    ..Here, we report the successful multidisciplinary management of five consecutive pregnant dialysis patients...
  27. ncbi request reprint Glutamine donor pretreatment in rat kidney transplants with severe preservation reperfusion injury
    T Florian Fuller
    Department of Urology, Charité University Hospital CCM, Berlin, Germany
    J Surg Res 140:77-83. 2007
    ..Glutamine (GLN) has been shown to confer cytoprotection by enhancing endogenous heat shock protein (HSP) expression. We hypothesized that GLN donor pretreatment protects rat renal grafts against severe preservation reperfusion injury (PRI)...
  28. ncbi request reprint Lectin-like oxidized low-density lipoprotein (LDL) receptor (LOX-1)-mediated pathway and vascular oxidative injury in older-age rat renal transplants
    Jan Hinrich Bräsen
    HELIOS Klinikum Berlin, Franz Volhard Clinic at the Max Delbrück Center for Molecular Medicine, Berlin, Germany
    Kidney Int 67:1583-94. 2005
    ..Reactive oxygen species participate in aging and in chronic vascular disease. We investigated how mediators of oxidative stress may increase allograft susceptibility to vascular injury...
  29. ncbi request reprint FTY720 mediates apoptosis-independent lymphopenia in human renal allograft recipients: different effects on CD62L+ and CCR5+ T lymphocytes
    Torsten Bohler
    Department of Nephrology, Charite, Campus Charite Mitte, Humboldt University, Berlin, Germany
    Transplantation 77:1424-32. 2004
    ..This study was designed to study the effect of FTY on lymphocyte subpopulations and apoptosis in stable renal allograft recipients...
  30. ncbi request reprint Review of the immunosuppressant enteric-coated mycophenolate sodium
    Klemens Budde
    Humboldt University, Department of Nephrology, Charite, Campus Charite Mitte, Schumannstrasse, D 10117 Berlin, Germany
    Expert Opin Pharmacother 5:1333-45. 2004
    ..EC-MPS therefore presents physicians and patients with a valid alternative MPA therapy with a comparable efficacy and safety profile to MMF...
  31. ncbi request reprint Reports of large immunosuppression trials in kidney transplantation: room for improvement
    Lutz Fritsche
    Department Nephrology, Charite Campus Mitte, Berlin, Germany
    Am J Transplant 4:738-43. 2004
    ..Additional efforts are required of investigators, editors and sponsors to achieve maximum study and reporting quality...
  32. ncbi request reprint Testosterone concentrations and sirolimus in male renal transplant patients
    Lutz Fritsche
    Department of Nephrology, Charite Campus Mitte, Berlin, Germany
    Am J Transplant 4:130-1. 2004
    ..In contrast, FSH and LH concentrations were higher while prolactin levels were not different. These data are consistent with sirolimus-related testosterone suppression and suggest a need for further studies...
  33. doi request reprint Novel signalling mechanisms and targets in renal ischaemia and reperfusion injury
    A Kusch
    Department of Nephrology and Intensive Care Medicine, Charite Campus Virchow Klinikum, Universitatsmedizin Berlin, Berlin, Germany
    Acta Physiol (Oxf) 208:25-40. 2013
    ..We summarize recent in vitro and in vivo experimental studies using pharmacological and genomic targeting and highlight some of the challenges to clinical application of these advances...
  34. doi request reprint Neutrophil gelatinase-associated lipocalin: pathophysiology and clinical applications
    E Singer
    Department of Nephrology, Campus Mitte, Charite Universitatsmedizin Berlin, Berlin, Germany
    Acta Physiol (Oxf) 207:663-72. 2013
    ....
  35. ncbi request reprint Toll-like receptor-4 modulates survival by induction of left ventricular remodeling after myocardial infarction in mice
    Alexander Riad
    Department of Cardiology and Pneumology, Charite University Medicine Berlin, Campus Benjamin Franklin, Berlin, Germany
    J Immunol 180:6954-61. 2008
    ..0001). TLR4 deficiency led to improved survival after MI mediated by attenuated left ventricular remodeling...
  36. doi request reprint Deoxycorticosterone acetate-salt mice exhibit blood pressure-independent sexual dimorphism
    Aysun Karatas
    Department of Nephrology and Intensive Care, Medicine Campus, Virchow Klinikum, Berlin, Germany
    Hypertension 51:1177-83. 2008
    ..We suggest that sex-specific calcineurin activation determines the maladaptive cardiac and renal hypertrophic responses and accompanying organ injury in male mice...
  37. doi request reprint Decreased transplant arteriosclerosis in endothelial nitric oxide synthase-deficient mice
    Hong Zebger-Gong
    Department of Pediatric Nephrology, Charite Universitatsmedizin Berlin, Campus Virchow Klinikum, Berlin, Germany
    Transplantation 89:518-26. 2010
    ..We have studied the role of NOS in a murine model of aortic allograft rejection...
  38. doi request reprint Involvement of functional autoantibodies against vascular receptors in systemic sclerosis
    Gabriela Riemekasten
    Department of Nephrology and Intensive Care Medicine, Charité University Hospital Campus Virchow Klinikum, Augustenburger Platz 1, 13353 Berlin, Germany
    Ann Rheum Dis 70:530-6. 2011
    ..The renin-angiotensin and endothelin systems have been implicated in vasculopathy and fibrosis. A role for autoantibody-mediated receptor stimulation is hypothesised, linking three major pathophysiological features consistent with SSc...
  39. doi request reprint Estrogen receptor-beta signals left ventricular hypertrophy sex differences in normotensive deoxycorticosterone acetate-salt mice
    Dennis Gürgen
    Department of Nephrology and Intensive Care Medicine Campus Virchow Klinikum, Center forCardiovascular Research Medical Faculty, Charite Berlin, Berlin, Germany
    Hypertension 57:648-54. 2011
    ..Our findings address the possibility of sex-specific cardiovascular therapies...
  40. doi request reprint mTOR regulates vascular smooth muscle cell differentiation from human bone marrow-derived mesenchymal progenitors
    Bjorn Hegner
    Clinic for Nephrology and Intensive Care Medicine, Charité Campus Virchow Klinihum, Augustenburger Platz 1, 13353 Berlin, Germany
    Arterioscler Thromb Vasc Biol 29:232-8. 2009
    ..We hypothesized that phosphoinositol-Akt-mammalian target of rapamycin-p70S6 kinase (PI3K/Akt/mTOR/p70S6K) pathway activation regulates VSMC differentiation from MSCs...
  41. doi request reprint Kidney transplantation into urinary conduits with ureteroureterostomy between transplant and native ureter: single-center experience
    Lyubov Chaykovska
    Department of Urology, Charité University Hospital Campus Mitte, Berlin, Germany
    Urology 73:380-5. 2009
    ..To evaluate the functional outcomes and complications after allogeneic kidney transplantation into recipients with a urinary conduit using ureteroureterostomy between the transplant and native ureter...
  42. ncbi request reprint Agonistic antibody-triggered stimulation of Angiotensin II type 1 receptor and renal allograft vascular pathology
    Duska Dragun
    Nephrol Dial Transplant 22:1819-22. 2007
  43. ncbi request reprint The role of angiotensin II type 1 receptor-activating antibodies in renal allograft vascular rejection
    Duska Dragun
    Pediatr Nephrol 22:911-4. 2007
    ..We have shown that the analysis of the subtle diagnostic and mechanistic differences may help to identify patients at particular risk and improve outcome of rejections with vascular pathology...
  44. doi request reprint Incidence and prediction of early antibody-mediated rejection due to non-human leukocyte antigen-antibodies
    Patrizia Amico
    Clinic for Transplantation Immunology and Nephrology, University Hospital Basel, Basel, Switzerland
    Transplantation 85:1557-63. 2008
    ..However, data on the incidence of early AMR due to non-HLA-DSA are currently lacking...
  45. ncbi request reprint Kidney-transplant rejection and anti-MICA antibodies
    Duska Dragun
    N Engl J Med 358:196; author reply 196. 2008
  46. doi request reprint T-lymphocyte infiltration in visceral adipose tissue: a primary event in adipose tissue inflammation and the development of obesity-mediated insulin resistance
    Ulrich Kintscher
    Department of Internal Medicine II Cardiology, University of Ulm, Robert Koch Str 8, D 89081 Ulm, Germany
    Arterioscler Thromb Vasc Biol 28:1304-10. 2008
    ..Adipose tissue inflammation may play a critical role in the pathogenesis of insulin resistance (IR). The present study examined the role of lymphocytes in adipose tissue inflammation and IR...
  47. doi request reprint N-Acetylcysteine does not artifactually lower plasma creatinine concentration
    Michael Haase
    Director of Intensive Care Research, Austin Hospital, University of Melbourne, 3084 Heidelberg, Victoria, Australia
    Nephrol Dial Transplant 23:1581-7. 2008
    ..However, it has been suggested that NAC may lower plasma creatinine levels independent of any effects on glomerular filtration rate (GFR)...
  48. ncbi request reprint Successful pregnancies in dialysis patients including those suffering from cystinosis and familial Mediterranean fever
    Michael Haase
    Department of Nephrology, Charite University Medicine, Berlin Germany
    J Nephrol 19:677-81. 2006
    ..These modified management guidelines have led to a favourable outcome in all our patients including two patients with familial Mediterranean fever and with cystinosis, and may help to guide therapy in other pregnant dialysis patients...
  49. ncbi request reprint Genetic polymorphisms in sepsis- and cardiopulmonary bypass-associated acute kidney injury
    Anja Haase-Fielitz
    Department of Intensive Care, Austin Health, Melbourne, Vic, Australia
    Contrib Nephrol 156:75-91. 2007
    ....
  50. ncbi request reprint Differential regulation of smooth muscle markers in human bone marrow-derived mesenchymal stem cells
    Bjorn Hegner
    Department of Medicine, Merheim Medical Center, Cologne General Hospital, Germany
    J Hypertens 23:1191-202. 2005
    ..To study smooth-muscle differentiation and de-differentiation of human bone marrow-derived mesenchymal stem cells (MSCs), which have been shown to enter the circulation and to contribute to vascular repair and atherosclerosis...