Thomas Dorner

Summary

Affiliation: Humboldt University
Country: Germany

Publications

  1. pmc Analysis of immunoglobulin light chain rearrangements in the salivary gland and blood of a patient with Sjögren's syndrome
    Annett M Jacobi
    Department of Internal Medicine Rheumatology and Clinical Immunology, Charite University Hospital, Berlin, Germany
    Arthritis Res 4:R4. 2002
  2. doi request reprint CD22 and autoimmune disease
    Thomas Dorner
    Charite University Medicine Berlin, CC12, Dept Medicine Rheumatology and Clinical Immunology and German Rheumatism Research Center Berlin DRFZ, Berlin, Germany
    Int Rev Immunol 31:363-78. 2012
  3. doi request reprint The role of biosimilars in the treatment of rheumatic diseases
    Thomas Dorner
    CC12 Department of Medicine, Rheumatology and Clinical Immunology, Charite University Medicine Berlin, Chariteplatz 1, Berlin 10117, Germany
    Ann Rheum Dis 72:322-8. 2013
  4. pmc Mechanisms of B cell autoimmunity in SLE
    Thomas Dorner
    Charité Center 12, Department of Medicine Rheumatology and Clinical Immunology, Charite Universitätsmedizin Berlin and Deutsches Rheumaforschungszentrum, Chariteplatz 01, 10117 Berlin, Germany
    Arthritis Res Ther 13:243. 2011
  5. doi request reprint SLE in 2011: Deciphering the role of NETs and networks in SLE
    Thomas Dorner
    Department of Medicine, Rheumatology and Clinical Immunology, Charité Center 12, Charite Universitätsmedizin Berlin and Deutsches Rheumaforschungszentrum, Chariteplatz 01, 10098 Berlin, Germany
    Nat Rev Rheumatol 8:68-70. 2012
  6. pmc Biomarkers as tools for improved diagnostic and therapeutic monitoring in systemic lupus erythematosis
    Michael F Smith
    Wyeth Research, Discovery Translational Medicine, Collegeville, PA 19426, USA
    Arthritis Res Ther 11:255. 2009
  7. ncbi request reprint Immunglobulin repertoire analysis provides new insights into the immunopathogenesis of Sjögren's syndrome
    Thomas Dorner
    Department of Medicine, Rheumatology and Clinical Immunology, University Hospital Charite, Schumannstrasse 20 21, 10098 Berlin, Germany
    Autoimmun Rev 1:119-24. 2002
  8. ncbi request reprint The role of B cells in rheumatoid arthritis: mechanisms and therapeutic targets
    Thomas Dorner
    Department of Rheumatology and Clinical Immunology, Charite University Hospital, Berlin, Germany
    Curr Opin Rheumatol 15:246-52. 2003
  9. doi request reprint New approaches of B-cell-directed therapy: beyond rituximab
    Thomas Dorner
    Charite Center 14, Charite University Hospital Berlin, Berlin, Germany
    Curr Opin Rheumatol 20:263-8. 2008
  10. ncbi request reprint B-cell targeting: a novel approach to immune intervention today and tomorrow
    Thomas Dorner
    Charite University Hospital Berlin and Deutsche Rheumaforschungszentrum, Chariteplatz 01, 10098 Berlin, Germany
    Expert Opin Biol Ther 7:1287-99. 2007

Detail Information

Publications133 found, 100 shown here

  1. pmc Analysis of immunoglobulin light chain rearrangements in the salivary gland and blood of a patient with Sjögren's syndrome
    Annett M Jacobi
    Department of Internal Medicine Rheumatology and Clinical Immunology, Charite University Hospital, Berlin, Germany
    Arthritis Res 4:R4. 2002
    ..These results suggest a role of antigen-activated and selected B cells in the local autoimmune process in SS...
  2. doi request reprint CD22 and autoimmune disease
    Thomas Dorner
    Charite University Medicine Berlin, CC12, Dept Medicine Rheumatology and Clinical Immunology and German Rheumatism Research Center Berlin DRFZ, Berlin, Germany
    Int Rev Immunol 31:363-78. 2012
    ..For example, the novel CD22-targeting monoclonal antibody epratuzumab is currently under investigation as a treatment for the connective tissue disorder systemic lupus erythematosus (SLE)...
  3. doi request reprint The role of biosimilars in the treatment of rheumatic diseases
    Thomas Dorner
    CC12 Department of Medicine, Rheumatology and Clinical Immunology, Charite University Medicine Berlin, Chariteplatz 1, Berlin 10117, Germany
    Ann Rheum Dis 72:322-8. 2013
    ..A panel of international experts in the field of rheumatology recently convened to evaluate and discuss these issues...
  4. pmc Mechanisms of B cell autoimmunity in SLE
    Thomas Dorner
    Charité Center 12, Department of Medicine Rheumatology and Clinical Immunology, Charite Universitätsmedizin Berlin and Deutsches Rheumaforschungszentrum, Chariteplatz 01, 10117 Berlin, Germany
    Arthritis Res Ther 13:243. 2011
    ....
  5. doi request reprint SLE in 2011: Deciphering the role of NETs and networks in SLE
    Thomas Dorner
    Department of Medicine, Rheumatology and Clinical Immunology, Charité Center 12, Charite Universitätsmedizin Berlin and Deutsches Rheumaforschungszentrum, Chariteplatz 01, 10098 Berlin, Germany
    Nat Rev Rheumatol 8:68-70. 2012
    ....
  6. pmc Biomarkers as tools for improved diagnostic and therapeutic monitoring in systemic lupus erythematosis
    Michael F Smith
    Wyeth Research, Discovery Translational Medicine, Collegeville, PA 19426, USA
    Arthritis Res Ther 11:255. 2009
    ....
  7. ncbi request reprint Immunglobulin repertoire analysis provides new insights into the immunopathogenesis of Sjögren's syndrome
    Thomas Dorner
    Department of Medicine, Rheumatology and Clinical Immunology, University Hospital Charite, Schumannstrasse 20 21, 10098 Berlin, Germany
    Autoimmun Rev 1:119-24. 2002
    ..The nature of the influences that lead to disordered selection in pSS remains to be determined, but should provide important clues to the etiology of this autoimmune inflammatory disorder...
  8. ncbi request reprint The role of B cells in rheumatoid arthritis: mechanisms and therapeutic targets
    Thomas Dorner
    Department of Rheumatology and Clinical Immunology, Charite University Hospital, Berlin, Germany
    Curr Opin Rheumatol 15:246-52. 2003
    ..This review will focus on recent findings of the role of B cells in rheumatoid arthritis and the implications to target B cells in this disease...
  9. doi request reprint New approaches of B-cell-directed therapy: beyond rituximab
    Thomas Dorner
    Charite Center 14, Charite University Hospital Berlin, Berlin, Germany
    Curr Opin Rheumatol 20:263-8. 2008
    ..This study reviews therapeutic approaches of direct and indirect B-cell targeting in autoimmune diseases and their impact on protective immunity...
  10. ncbi request reprint B-cell targeting: a novel approach to immune intervention today and tomorrow
    Thomas Dorner
    Charite University Hospital Berlin and Deutsche Rheumaforschungszentrum, Chariteplatz 01, 10098 Berlin, Germany
    Expert Opin Biol Ther 7:1287-99. 2007
    ....
  11. pmc Selecting B cells and plasma cells to memory
    Thomas Dorner
    University Hospital Berlin and Deutsches Rheumaforschungszentrum Berlin, 10098 Berlin, Germany
    J Exp Med 201:497-9. 2005
    ..How these differentiation pathways relate to each other, how cells are selected into these memory populations, and how these populations are maintained remains enigmatic...
  12. ncbi request reprint Signalling pathways in B cells: implications for autoimmunity
    T Dorner
    Institute of Transfusion Medicine, Charite University Medicine Berlin, Coagulation Unit, Germany
    Curr Top Microbiol Immunol 305:213-40. 2006
    ....
  13. pmc Initial clinical trial of epratuzumab (humanized anti-CD22 antibody) for immunotherapy of systemic lupus erythematosus
    Thomas Dorner
    Department of Medicine Rheumatology and Clinical Immunology, Charite Hospital, Berlin, Germany
    Arthritis Res Ther 8:R74. 2006
    ..As such, multicenter controlled studies are being conducted in broader patient populations...
  14. ncbi request reprint [Apoptosis marker enzyme poly-(ADP-ribose) polymerase (PARP) in systemic lupus erythematosus]
    T Dorner
    Klinische Hämostaseologie, Institut fur Transfusionsmedizin, Charité Universitätsmedizin Berlin und Deutsches Rheumaforschungszentrum Berlin
    Z Rheumatol 65:545. 2006
  15. ncbi request reprint Antibodies against protein Z and fetal loss: current perspectives
    T Dorner
    Coagulation Unit, Institute of Transfusion Medicine, Charite University Medicine Berlin, Free University and Humboldt University Berlin, Schumannstrasse 20 21, D 10098, Berlin, Germany
    Clin Exp Med 5:50-4. 2005
    ..The current diagnostic relevance and therapeutic consequences of these parameters will be discussed...
  16. ncbi request reprint Molecular basis of immunoglobulin variable region gene usage in systemic autoimmunity
    T Dorner
    Department of Transfusion Medicine, Charite University Medicine, Schumannstr 20 21, 10098 Berlin, Germany
    Clin Exp Med 4:159-69. 2005
    ..Identification of the mechanisms that influence the IgV gene and B-cell repertoire may allow new therapeutic approaches in autoimmunity...
  17. pmc Autoantibodies in normals--the value of predicting rheumatoid arthritis
    Thomas Dorner
    Charite University Medicine Berlin, Free University and Humboldt University Berlin, Berlin, Germany
    Arthritis Res Ther 6:282-4. 2004
  18. doi request reprint B-cell-directed therapies for autoimmune disease
    Thomas Dorner
    Charite Center 12 and 14, Charité University Hospital and Deutsches Rheuma Forschungszentrum Berlin, Berlin, Germany
    Nat Rev Rheumatol 5:433-41. 2009
    ....
  19. doi request reprint Current status on B-cell depletion therapy in autoimmune diseases other than rheumatoid arthritis
    Thomas Dorner
    Charité Medicine University, Berlin, Germany
    Autoimmun Rev 9:82-9. 2009
    ..However, given the lack of robust data from large randomised controlled trials, anti-CD20 therapy should be considered on an individual basis in otherwise refractory patients and its use based on a risk/benefit net calculation...
  20. pmc B cells in autoimmunity
    Thomas Dorner
    Charite Center 12 and 14, Charite University Hospital and DRFZ Berlin, Chariteplatz 01, 10098 Berlin, Germany
    Arthritis Res Ther 11:247. 2009
    ..Based on preclinical and clinical data, B cells have emerged increasingly as both effector cells as well as cells with immunoregulatory potential...
  21. pmc Challenges in understanding Sjögren's syndrome--improved insights into the pathogenesis generate hope for innovative therapies?
    Thomas Dorner
    Arthritis Res Ther 13:123. 2011
    ..Potential therapeutic targets, such as blockade of the B cell-activating factor, the role of interferon-alpha, and targeting CD22, are discussed...
  22. pmc Perturbations in the impact of mutational activity on Vlambda genes in systemic lupus erythematosus
    T Dorner
    Department of Medicine, University Hospital Charite, Berlin, Germany
    Arthritis Res 3:368-74. 2001
    ..The enhanced and abnormal mutational activity along with disturbances in selection may play a role in the emergence of autoreactivity in this patient with SLE...
  23. pmc Safety and clinical outcomes of rituximab therapy in patients with different autoimmune diseases: experience from a national registry (GRAID)
    Hans Peter Tony
    Medizinische Klinik und Poliklinik II, Universitatsklinikum Wurzburg, Klinikstr 6 8, 97070 Wurzburg, Germany
    Arthritis Res Ther 13:R75. 2011
    ....
  24. doi request reprint Abnormalities of B cell subsets in patients with systemic lupus erythematosus
    Thomas Dorner
    Dept Medicine Rheumatology and Clinical Immunology, Charite Universitätsmedizin Berlin and Deutsches Rheumaforschungszentrum, Chariteplatz 01, 10098 Berlin, Germany
    J Immunol Methods 363:187-97. 2011
    ..Together, these analyses have provided new insights on the role of B cell over-reactivity in SLE...
  25. ncbi request reprint Significance of autoantibodies in neonatal lupus erythematosus
    T Dorner
    Department of Medicine Rheumatology and Clinical Immunology, Charite Medical School, Humboldt University, Berlin, Germany
    Int Arch Allergy Immunol 123:58-66. 2000
    ..Current knowledge about the involved autoantibody-autoantigen systems, including recent therapeutic concepts of these autoimmune syndromes, is summarized...
  26. ncbi request reprint Implant-related inflammatory arthritis
    Thomas Dorner
    Coagulation Unit, Institute of Transfusion Medicine, Charite University Medicine, Berlin, Germany
    Nat Clin Pract Rheumatol 2:53-6; quiz 57. 2006
    ..The patient had received a wrought titanium 6-aluminium 4-vanadium alloy C cage implant 1.5 years previously, following a severe disc prolapse. No signs of rheumatic disease were evident before the C cage was implanted...
  27. ncbi request reprint [Cytometric analyses in systemic autoimmune diseases]
    T Dorner
    Med Klinik m S Rheumatologie und Klin Immunologie, Charité Berlin Schumannstr 20 21 10098 Berlin, Germany
    Z Rheumatol 61:389-95. 2002
    ....
  28. ncbi request reprint Generation of migratory antigen-specific plasma blasts and mobilization of resident plasma cells in a secondary immune response
    Marcus Odendahl
    Department of Medicine, Charite, Humbold University, D 10117 Berlin, Germany
    Blood 105:1614-21. 2005
    ....
  29. ncbi request reprint Diminished peripheral blood memory B cells and accumulation of memory B cells in the salivary glands of patients with Sjögren's syndrome
    Arne Hansen
    University Hospital Charite, Berlin, Germany
    Arthritis Rheum 46:2160-71. 2002
    ..To delineate the mechanism of the abnormalities in B cell biology found in patients with primary Sjögren's syndrome (SS)...
  30. ncbi request reprint Correlation between circulating CD27high plasma cells and disease activity in patients with systemic lupus erythematosus
    Annett M Jacobi
    University Hospital Charite, Berlin, Germany
    Arthritis Rheum 48:1332-42. 2003
    ..In order to determine whether SLE disease activity correlates with abnormal B lymphocyte activity, B cell subsets were analyzed, and their relationship to clinical and humoral measures of disease activity was assessed...
  31. ncbi request reprint Chronic lymphocytic leukemia preceded by cold agglutinin disease: intraclonal immunoglobulin light-chain diversity in V(H)4-34 expressing single leukemic B cells
    Sarka Ruzickova
    Deutsches Rheumaforschungszentrum, Berlin, Germany
    Blood 100:3419-22. 2002
    ..Of note, our findings suggest that this B-CLL had developed from the patient's CA-producing B-cell population...
  32. ncbi request reprint CD38 low IgG-secreting cells are precursors of various CD38 high-expressing plasma cell populations
    Sergio Arce
    Deutsches Rheuma ForschungsZentrum Berlin, Schumannstrasse 20 21, D 10117 Berlin, Germany
    J Leukoc Biol 75:1022-8. 2004
    ..These data are compatible with a multistep model for plasma cell differentiation and imply that a common CD38 low IgG-secreting precursor gives rise to a diverse plasma cell compartment...
  33. pmc The anti-CD74 humanized monoclonal antibody, milatuzumab, which targets the invariant chain of MHC II complexes, alters B-cell proliferation, migration, and adhesion molecule expression
    Daniela Frölich
    Department of Medicine, Rheumatology and Clinical Immunology, Charite University Medicine Berlin, Chariteplatz 1, Berlin 10117, Germany
    Arthritis Res Ther 14:R54. 2012
    ..Therefore, the current study addressed the influence of milatuzumab on B-cell proliferation, chemo-attractant migration, and adhesion molecule expression...
  34. doi request reprint Secondary immunization generates clonally related antigen-specific plasma cells and memory B cells
    Daniela Frölich
    Department of Medicine, Rheumatology, and Clinical Immunology, Charite University Medicine Berlin, Germany
    J Immunol 185:3103-10. 2010
    ..These results suggest that after the fate decision to differentiate into secondary memory B cells or PCs, some committed precursors continue to proliferate and mutate their V(H) genes...
  35. doi request reprint Activated memory B cell subsets correlate with disease activity in systemic lupus erythematosus: delineation by expression of CD27, IgD, and CD95
    Annett M Jacobi
    Charite Universitatsmedizin Berlin, Berlin, Germany
    Arthritis Rheum 58:1762-73. 2008
    ..Focusing on CD27- B cells, this study aimed to identify abnormalities in peripheral B cell subsets in patients with SLE...
  36. ncbi request reprint Tissue distribution and dependence of responsiveness of human antigen-specific memory B cells
    Claudia Giesecke
    Medizinische Klinik mit Schwerpunkt Rheumatologie und Klinische Immunologie, Charite Universitatsmedizin Berlin, 10117 Berlin, Germany
    J Immunol 192:3091-100. 2014
    ..The spleen and tonsil, although harboring the largest number of overall and TT(+) mBCs, appear to be dispensable to preserve adequate responsiveness to secondary antigenic challenge. ..
  37. doi request reprint Steady-state generation of mucosal IgA+ plasmablasts is not abrogated by B-cell depletion therapy with rituximab
    Henrik E Mei
    German Rheumatism Research Center Berlin DRFZ, Berlin, Germany
    Blood 116:5181-90. 2010
    ..These data suggest that a population of mucosal B cells is self-sufficient in adult humans and not replenished by CD20(+) B cells immigrating from blood, lymphoid tissue, or bone marrow, that is, B cells depleted by rituximab...
  38. doi request reprint Role of the spleen in peripheral memory B-cell homeostasis in patients with autoimmune thrombocytopenia purpura
    Lorena Martinez-Gamboa
    Charité Center 14 for Tumor Medicine, Institute for Transfusion Medicine and Immune Hematology, Charite University Hospital, Berlin, Germany
    Clin Immunol 130:199-212. 2009
    ..Thus, the spleen plays a fundamental role in controlling peripheral memory B cell homeostasis in both AITP and HD and regulates activated CD95+ B cells in patients with AITP...
  39. ncbi request reprint Long-lived plasma cells in immunity and immunopathology
    Katrin Moser
    German Arthritis Research Center Berlin, Schumannstrasse 20 21, 10117 Berlin, Germany
    Immunol Lett 103:83-5. 2006
    ..Autoreactive plasma cells in the spleen are present long before the onset of the disease, suggesting that these cells contribute to induction of immunopathology...
  40. pmc Epratuzumab targeting of CD22 affects adhesion molecule expression and migration of B-cells in systemic lupus erythematosus
    Capucine Daridon
    Charite Universitatsmedizin Berlin, CC12 Dept, Medicine Rheumatology and Clinical Immunology, Chariteplatz 1, Berlin 10117, Germany
    Arthritis Res Ther 12:R204. 2010
    ..Therefore, potential effects of epratuzumab on adhesion molecule expression and the migration of B-cells have been evaluated...
  41. ncbi request reprint Abnormalities in peripheral B cell memory of patients with primary Sjögren's syndrome
    Arne Hansen
    Department of Medicine Outpatients Department, Charite University Hospital, Berlin, Germany
    Arthritis Rheum 50:1897-908. 2004
    ..To delineate disturbances in peripheral B cell memory in primary Sjögren's syndrome (SS)...
  42. ncbi request reprint Phenotypic analysis of B-cells and plasma cells
    Henrik E Mei
    German Rheumatism Research Centre, Berlin, Germany
    Methods Mol Med 136:3-18. 2007
    ....
  43. doi request reprint Splenic proliferative lymphoid nodules distinct from germinal centers are sites of autoantigen stimulation in immune thrombocytopenia
    Capucine Daridon
    CC12 Department of Medicine, Rheumatology and Clinical Immunology, Charite University Medicine Berlin, Berlin, Germany
    Blood 120:5021-31. 2012
    ..Autoantigens were not found in the GCs of ITP or controls indicating that PLNs are the sites of autoantigen stimulation in ITP potentially related to a lack of control by T cells and/or the present autoantigen...
  44. pmc Detailed analysis of the variability of peptidylarginine deiminase type 4 in German patients with rheumatoid arthritis: a case-control study
    Berthold Hoppe
    Institute of Transfusion Medicine, Campus Virchow Klinikum, Charite Universitatsmedizin Berlin, Germany
    Arthritis Res Ther 8:R34. 2006
    ..Quantitative or qualitative differences in previously undefined PADI4 variants between patients and controls could not be demonstrated...
  45. doi request reprint Long-lived autoreactive plasma cells drive persistent autoimmune inflammation
    Falk Hiepe
    Klinik m S Rheumatologie und Klin Immunologie, Charite Universitatsmedizin Berlin, Chariteplatz 1, Berlin, Germany
    Nat Rev Rheumatol 7:170-8. 2011
    ..Thus, long-lived plasma cells appear to be a promising new therapeutic target...
  46. ncbi request reprint Dysregulation of chemokine receptor expression and function by B cells of patients with primary Sjögren's syndrome
    Arne Hansen
    Department of Medicine, Outpatient Department, Charite University Hospital, Berlin, Germany
    Arthritis Rheum 52:2109-19. 2005
    ..To assess whether abnormal chemokine receptor expression and/or abnormal responsiveness to the cognate ligands might underlie some of the disturbances in B cell homeostasis characteristic of primary Sjögren's syndrome (SS)...
  47. ncbi request reprint Circulating proteasomes are markers of cell damage and immunologic activity in autoimmune diseases
    Karl Egerer
    Department of Rheumatology and Clinical Immunology, Institute of Biochemistry, Humboldt University of Berlin, Berlin, Germany
    J Rheumatol 29:2045-52. 2002
    ....
  48. ncbi request reprint Involvement of inducible costimulator in the exaggerated memory B cell and plasma cell generation in systemic lupus erythematosus
    Andreas Hutloff
    Robert Koch Institute, Berlin, Germany
    Arthritis Rheum 50:3211-20. 2004
    ..We undertook this study to determine the biologic mechanism driving this overactivation of the B cell compartment, which is the central issue in SLE...
  49. doi request reprint Anticytokine therapy impacting on B cells in autoimmune diseases
    Capucine Daridon
    Department of Rheumatology and Clinical Immunology, Charité University Medicine Berlin and Deutsches, Rheumaforschungszentrum, Berlin 10098, Germany
    Curr Opin Rheumatol 21:205-10. 2009
    ....
  50. doi request reprint Memory B and memory plasma cells
    Taketoshi Yoshida
    Charité Centre 12, Clinic for Internal Medicine, Rheumatology, Clinical Immunology, Charite University Hospital Berlin, Berlin, Germany
    Immunol Rev 237:117-39. 2010
    ..Their selective targeting will depend on a molecular understanding of their lifestyle...
  51. ncbi request reprint Cryopreserved human B cells as an alternative source for single cell mRNA analysis
    Arne Hansen
    Outpatients Department of Medicine, Charite University Medicine Berlin, Germany
    Cell Tissue Bank 6:299-308. 2005
    ..However, the settings for both FACS analysis and RT-PCR should be re-evaluated for each distinct subpopulation and target mRNA of interest when analyzing post-thawed cells...
  52. ncbi request reprint Crossroads of B cell activation in autoimmunity: rationale of targeting B cells
    Thomas Dorner
    Charité University Hospital Berlin and the Deutsches Rheumaforschungszentrum, Berlin, Germany
    J Rheumatol Suppl 77:3-11. 2006
    ..B cell targeted therapies in human trials include an anti-B lymphocyte stimulator protein agent, belimumab; an anti-CD20 agent, rituximab; and an anti-CD22 antibody, epratuzumab...
  53. doi request reprint Delayed acquisition of somatic hypermutations in repopulated IGD+CD27+ memory B cell receptors after rituximab treatment
    Khalid Muhammad
    Medizinische Klinik II, Department of Rheumatology and Clinical Immunology, University of Wurzburg, Wurzburg, Germany
    Arthritis Rheum 60:2284-93. 2009
    ..This study was undertaken to determine whether mutational acquisition in individual B cell receptors in repopulating class-switched and non-class-switched memory B cells is affected by rituximab...
  54. ncbi request reprint Tissue-specific up-regulation of the proteasome subunit beta5i (LMP7) in Sjögren's syndrome
    Thomas Egerer
    Charite Universitatsmedizin Berlin, Humboldt University of Berlin, Berlin, Germany
    Arthritis Rheum 54:1501-8. 2006
    ..Since these histologic findings are nonspecific, determination of clinical and serologic abnormalities contribute to the diagnosis. The aim of this study was to identify a novel, disease-specific, immunologically relevant marker for SS...
  55. ncbi request reprint Gene polymorphisms implicated in influencing susceptibility to venous and arterial thromboembolism: frequency distribution in a healthy German population
    Berthold Hoppe
    Institute of Transfusion Medicine, Campus Benjamin Franklin, Charité Universitätsklinikum Berlin, Berlin, Germany
    Thromb Haemost 96:465-70. 2006
    ....
  56. ncbi request reprint B-cell lymphoproliferation in chronic inflammatory rheumatic diseases
    Arne Hansen
    Outpatients Department of Medicine, Charite University Hospital, Berlin, Germany
    Nat Clin Pract Rheumatol 3:561-9. 2007
    ..This Review will focus on the risk of lymphoma, common and disease-specific mechanisms of B-cell lymphoma development, and on the clinical consequences of lymphoma in patients with inflammatory rheumatic diseases...
  57. doi request reprint Fibrinogen and factor XIII A-subunit genotypes interactively influence C-reactive protein levels during inflammation
    Berthold Hoppe
    Institute of Laboratory Medicine, Clinical Chemistry and Pathobiochemistry, Charite Universitatsmedizin Berlin, Campus Virchow Klinikum, Augustenburger Platz 1, 13353 Berlin, Germany
    Ann Rheum Dis 71:1163-9. 2012
    ....
  58. pmc Kitasato symposium 2009: new prospects for cytokine inhibition
    Gerd R Burmester
    CC12, Charite Universitatsmedizin Berlin, Chariteplatz 01, 10098 Berlin, Germany
    Arthritis Res Ther 11:301. 2009
    ..The involvement of cytokines in other autoimmune diseases was also addressed...
  59. doi request reprint Blood-borne human plasma cells in steady state are derived from mucosal immune responses
    Henrik E Mei
    Center for Tumor Medicine, Institute of Transfusion Medicine, Charite University Hospital, Berlin, Germany
    Blood 113:2461-9. 2009
    ..Systemic vaccination does not impact on peripheral IgA(+) plasmablast numbers, indicating that mucosal and systemic humoral immune responses are regulated independent of each other...
  60. doi request reprint Blood dendritic cells in systemic lupus erythematosus exhibit altered activation state and chemokine receptor function
    Velia Gerl
    Department of Rheumatology and Clinical Immunology, Charite Universitatsmedizin Berlin, Chariteplatz 1, 10117 Berlin, Germany
    Ann Rheum Dis 69:1370-7. 2010
    ..Reduced numbers of blood DCs and the accumulation of DCs at inflammatory sites have been observed in SLE. One crucial feature of DCs is their ability to migrate...
  61. doi request reprint Targeting B cells in immune-mediated inflammatory disease: a comprehensive review of mechanisms of action and identification of biomarkers
    Thomas Dorner
    Charité Center 12, Dept Rheumatology and Clinical Immunology, Charité University Hospital Berlin and Deutsches Rheumaforschungszentrum, Berlin, Germany
    Pharmacol Ther 125:464-75. 2010
    ..In patients with systemic lupus erythematosus, Fc receptors and levels of circulating immune cells (including B cells and natural killer cells) may be relevant markers...
  62. pmc Rationale of anti-CD19 immunotherapy: an option to target autoreactive plasma cells in autoimmunity
    Henrik E Mei
    German Rheumatism Research Center, DRFZ, Chariteplatz 01, 10117 Berlin, Germany
    Arthritis Res Ther 14:S1. 2012
    ....
  63. ncbi request reprint Competence and competition: the challenge of becoming a long-lived plasma cell
    Andreas Radbruch
    Deutsches Rheuma ForschungsZentrum Berlin, Chariteplatz 1, D 10117 Berlin, Germany
    Nat Rev Immunol 6:741-50. 2006
    ..This mechanism is based on competition for survival niches between newly generated plasmablasts and older plasma cells...
  64. ncbi request reprint High-level serum B-cell activating factor and promoter polymorphisms in patients with idiopathic thrombocytopenic purpura
    Florian Emmerich
    Institute for Transfusion Medicine, Charite University Medicine Berlin, Berlin, Germany
    Br J Haematol 136:309-14. 2007
    ..This promoter variant was associated with very high BAFF levels in ITP patients. Our data suggest that BAFF is an important pathogenetic factor in the development of ITP...
  65. ncbi request reprint Adaptation of humoral memory
    Thomas Hofer
    Humboldt Universitat Berlin, Theoretische Biophysik, Institut f Biologie, Berlin, Germany
    Immunol Rev 211:295-302. 2006
    ....
  66. doi request reprint Rituximab therapy leads to reduced imprints of receptor revision in immunoglobulin κ and λ light chains
    Arumugam Palanichamy
    Department of Rheumatology and Clinical Immunology, Medizinische Klinik und Poliklinik II, Oberdürrbacherstr 6, 97080 Wurzburg, Germany
    J Rheumatol 39:1130-8. 2012
    ..Although phenotypic repopulation kinetics of B cell subsets are well documented, precise molecular analyses of the reconstituting immunoglobulin (Ig) genes encoding the B cell receptor in RA are sparse...
  67. pmc Differential expression of chemokine receptors on peripheral blood B cells from patients with rheumatoid arthritis and systemic lupus erythematosus
    Maren Henneken
    Deutsches Rheuma ForschungsZentrum, Berlin, Germany
    Arthritis Res Ther 7:R1001-13. 2005
    ..However, differences between patients with RA and patients with SLE point toward a disease-specific regulation of receptor expression. These differences may influence the migrational behavior of B cells...
  68. pmc B cells in Sjögren's syndrome: indications for disturbed selection and differentiation in ectopic lymphoid tissue
    Arne Hansen
    Charite Center CC 12, Department of Medicine, Charite Universitatsmedizin Berlin, Charité Platz 01, 10098 Berlin, Germany
    Arthritis Res Ther 9:218. 2007
    ..These findings add to our understanding of the pathogenesis of this autoimmune inflammatory disorder and may result in new therapeutic approaches...
  69. doi request reprint What do we know about memory B cells in primary Sjögren's syndrome?
    Arne Hansen
    Department of Medicine, Park Klinik Weissensee, Berlin, Germany
    Autoimmun Rev 9:600-3. 2010
    ..Thus, B cells may be potential targets of direct or indirect treatment in pSS...
  70. doi request reprint Use of heparin in women with early and late miscarriages with and without thrombophilia
    Silke Monien
    Department of Hemostaseology, Institute of Transfusion Medicine, Charite University Hospital Berlin, Berlin, Germany
    Clin Appl Thromb Hemost 15:636-44. 2009
    ..Because of the fact that heparin has both anticoagulative and anti-inflammatory effects, the current study evaluated the efficacy of low-molecular-weight heparin (LMWH) in unexplained abortions...
  71. ncbi request reprint The role of long-lived plasma cells in autoimmunity
    Sergio Arce
    German Rheumatism Research Center, Berlin, Germany
    Immunobiology 206:558-62. 2002
    ..Here, we discuss the potential involvement of long-lived plasma cells in the pathogenesis of autoimmune disease and the consequences it has for the development of effective therapeutic strategies...
  72. doi request reprint Patient-tailored therapy in rheumatoid arthritis: an editorial review
    Hans U Scherer
    Department of Rheumatology and Clinical Immunology, Charite University Medicine Berlin, Germany
    Curr Opin Rheumatol 22:237-45. 2010
    ..Such personalized, patient-tailored therapy is still not a reality in rheumatology practice. However, several important steps have recently been made towards achievement of this important goal...
  73. pmc Rapid detection of autoantibodies to dsDNA with the particle gel immunoassay (ID-PaGIA)
    A Seltsam
    Institute of Transfusion Medicine, Charité University Hospital Virchow Clinic, Humboldt University Berlin, Germany
    Ann Rheum Dis 61:367-9. 2002
    ..To describe a new particle agglutination test for the detection of autoantibodies to double stranded DNA (dsDNA)...
  74. ncbi request reprint B*4440: a novel HLA-B allele identified by sequence-specific oligonucleotide hybridization and sequence-specific amplification
    G A Heymann
    Institute of Transfusion Medicine, Campus Virchow Klinikum, Charite Universitatsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
    Tissue Antigens 65:195-8. 2005
    ..DNA sequencing confirmed a variation of codons 44 and 45 (AGG AAG-->AGA GAG) and codon 50 (CCA-->CCG), resulting in an amino acid substitution Lys-->Glu at codon 45...
  75. pmc Kitasato Symposium 2010: new prospects for cytokines
    Gerd R Burmester
    CC12, Charite Universitatsmedizin Berlin, Chariteplatz 01, 10098 Berlin, Germany
    Arthritis Res Ther 12:301. 2010
    ..The presentations at the Symposium resulted in productive discussions regarding potential new targets for the treatment of rheumatoid arthritis and other autoimmune disorders...
  76. pmc Developments in lupus 2006
    Arne Hansen
    Charite Centrum 12, Charite University Medicine, Chariteplatz 01, 10098 Berlin, Germany
    Arthritis Res Ther 9:215. 2007
    ..Although it remains to be shown which of those could be targets for therapy or biomarkers, lymphocyte-directed therapy is currently under promising clinical investigation...
  77. ncbi request reprint Antibodies and B cell memory in viral immunity
    Thomas Dorner
    Charite Universitätsmedizin Berlin and Deutsches Rheumaforschungszentrum Berlin, 10117 Berlin, Germany
    Immunity 27:384-92. 2007
    ..e., HIV) have managed to develop specific evasion strategies to escape it. Thus, coevolution provides us with some insight into just how substantial antiviral antibodies and memory B cell are in protecting the host from virus infection...
  78. ncbi request reprint Marburg I polymorphism of factor VII-activating protease is associated with idiopathic venous thromboembolism
    Berthold Hoppe
    Institutee of Transfusion Meidicine, Campus Virchow Klinikum, Charite Universitatsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
    Blood 105:1549-51. 2005
    ..3%). Logistic regression analysis confirmed FSAP Marburg I to be an independent risk factor for VTE (odds ratio, 3.5; 95% confidence interval [CI], 1.2-10.0) and idiopathic VTE (odds ratio, 6.2; 95% CI, 2.0-18.9)...
  79. ncbi request reprint Immunopathogenesis of primary Sjögren's syndrome: implications for disease management and therapy
    Arne Hansen
    Charite University Medicine Berlin, Germany
    Curr Opin Rheumatol 17:558-65. 2005
    ..This review highlights recent advances in understanding the underlying mechanisms of the disease as well as their implications for clinical handling and therapeutic options...
  80. pmc Abnormalities of B cell phenotype, immunoglobulin gene expression and the emergence of autoimmunity in Sjögren's syndrome
    Thomas Dorner
    Department of Medicine, Rheumatology and Clinical Immunology, University Hospital Charite, Berlin, Germany
    Arthritis Res 4:360-71. 2002
    ..Because disordered selection leads to considerable differences in the B cell repertoire in these patients, the delineation of its nature should provide important further clues to the pathogenesis of this autoimmune inflammatory disorder...
  81. ncbi request reprint [B-cell depletion in the treatment of rheumatoid arthritis]
    Eugen Feist
    Medizinische Klinik mit Schwerpunkt Rheumatologie und Klinische Immunologie, Universitätsklinikum Charité Humboldt Universität zu Berlin, Berlin, Germany
    Z Rheumatol 62:361-6. 2003
    ..Here, we discuss recent data of a temporary B cell depletion using a monoclonal anti-CD20 antibody in the therapeutic arsenal of rheumatoid arthritis...
  82. ncbi request reprint Cutaneous T cell lymphoma in a patient with primary biliary cirrhosis and secondary Sjögren's syndrome
    Arne Stroehmann
    Department of Anaesthesiology and Intensive Care Medicine, Charite University Hospital, Humboldt University, Berlin, Germany
    J Rheumatol 29:1326-9. 2002
    ..There are few reports of T cell lymphoma in primary SS. The occurrence of a T cell lymphoma in a patient with PBC and secondary SS indicates the necessity to investigate lymphoma in patients with secondary SS...
  83. doi request reprint Experiences with recombinant FVIIa in the emergency treatment of patients with autoimmune thrombocytopenia: a review of the literature
    A Salama
    Institut fur Transfusionsmedizin, Charite Universitatsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
    Ann Hematol 88:11-5. 2009
    ..The results indicate that rFVIIa may help in the emergency treatment of patients with ITP who do not respond to other therapies...
  84. ncbi request reprint Immune hemolysis-serological and clinical aspects
    A Pruss
    Institute for Transfusion Medicine, University Hospital Charite, Medical Faculty of the Humboldt University of Berlin, Schumannstrasse 20 21, 10117 Berlin, Germany
    Clin Exp Med 3:55-64. 2003
    ..Finally, current and partly experimental therapeutic strategies of immune hemolytic anemias are summarized...
  85. ncbi request reprint Immunomagnetic selection of CD34+ cells: factors influencing component purity and yield
    M Hildebrandt
    Departments of Internal Medicine Blood Bank and Pediatrics, Charite, Campus Virchow Klinikum, Humboldt University, Berlin, Germany
    Transfusion 40:507-12. 2000
    ..In immunomagnetic selection of CD34+ cells from HPC transplants, not all factors that affect yield and purity of CD34+ cells are known...
  86. doi request reprint Haplotype-specific sequencing reveals a novel HLA-B*37 allele, B*3714
    F Emmerich
    Center for Tumor Medicine, Institute for Transfusion Medicine, Charite University Medicine, Berlin, Germany
    Tissue Antigens 73:67. 2009
    ..The first one leads to the exchange from arginine to leucine at position 82, and the latter one from glycine to arginine at position 83...
  87. ncbi request reprint Dipeptidyl peptidase IV (DP IV, CD26) in patients with inflammatory bowel disease
    M Hildebrandt
    Dept of Psychosomatic Medicine, Humboldt Universitat zu Berlin, Germany
    Scand J Gastroenterol 36:1067-72. 2001
    ..We hypothesized that the activity of DP IV in serum and expression of CD26/DP IV in lymphocytes may be altered in patients with inflammatory bowel disease (IBD)...
  88. doi request reprint Identification of a novel HLA-B allele, HLA-B*5529, by haplotype-specific sequencing
    F Emmerich
    Center for Tumor Medicine, Institute for Transfusion Medicine, Charite University Medicine, Berlin, Germany
    Tissue Antigens 71:486. 2008
    ..Thus, the newly found allele is estimated to have a low alloreactive potential in case of a mismatch to the most common HLA-B allele B*5501...
  89. pmc Immune tolerance induction in patients with IgA anaphylactoid reactions following long-term intravenous IgG treatment
    N Ahrens
    Institute for Transfusion Medicine, Charite University Medicine Berlin, Germany
    Clin Exp Immunol 151:455-8. 2008
    ..Most importantly, IgA appears to play an important role in the treatment of CVID. Patients with IgA anaphylactoid reactions can be treated safely with IgA containing i.v. IgG preparations following tolerance induction...
  90. ncbi request reprint A novel HLA-B*270509 variant escaping detection by PCR-SSO-based histotyping
    G A Heymann
    Institute of Transfusion Medicine, Campus Virchow Klinikum, Charite Universitatsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
    Tissue Antigens 66:702-3. 2005
  91. ncbi request reprint [Aquired immune hemolytic anemias]
    A Salama
    Medizinische Fakultät der Humboldt Universität, Institut für Bluttransfusionen, Campus Virchow Klinikum, Charite, Berlin
    Ther Umsch 61:178-86. 2004
    ..The true incidence of alloimmune hemolytic anemias including neonatal immune hemolytic anemias is unknown. The paroxysmal nocturnal hemoglobinuria is rare. It is caused by complement activation due to aquired membrane defects...
  92. ncbi request reprint Detection of a new weak A blood-group allele (Aw11)
    A Pruss
    Institute of Transfusion Medicine Universitätsmedizin Berlin, Berlin, Germany
    Vox Sang 90:195-7. 2006
    ..Weak ABO variants may escape tests using unlicensed sera...
  93. ncbi request reprint Identification and characterization of a novel HLA-DRB1 allele, DRB1*0830*
    B Hoppe
    Institute of Transfusion Medicine, Campus Virchow Klinikum, Charite Universitatsmedizin Berlin, Berlin, Germany
    Tissue Antigens 66:160-2. 2005
    ..Allele-specific DNA sequencing confirmed a 286 T-->A substitution resulting in Phe67Ile...
  94. ncbi request reprint A novel HLA-A*680104 variant
    G A Heymann
    Institute of Transfusion Medicine, Campus Virchow Klinikum, Charite Universitatsmedizin Berlin, Berlin, Germany
    Tissue Antigens 67:169-70. 2006
  95. ncbi request reprint Immunoadsorption patients with multiple sclerosis: an open-label pilot study
    A Moldenhauer
    Charite Universitatsmedizin Berlin, Germany
    Eur J Clin Invest 35:523-30. 2005
    ..This pilot study was undertaken to determine whether IA might help in secondary progressive and relapsing-remitting multiple sclerosis...
  96. ncbi request reprint CD47 is expressed at normal levels in patients with autoimmune haemolytic anaemia and/or immune thrombocytopenia
    N Ahrens
    Institute for Transfusion Medicine, Charite Universitatsmedizin Berlin, Berlin, Germany
    Transfus Med 16:397-402. 2006
    ..Similarly, CD47 was detectable in the plasma of the studied subjects. No evidence for a pathogenetic role of CD47 in autoimmune haemolysis or thrombocytopenia in humans could be demonstrated...
  97. ncbi request reprint A novel antigen-specific capture assay for the detection of platelet antibodies and HPA-1a phenotyping
    O Meyer
    Charite, Universitatsmedizin Berlin, Institut fur Transfusionsmedizin, Berlin, Germany
    Vox Sang 91:324-30. 2006
    ..Here, we describe a simple antigen-specific capture assay (ASCA) for the detection of serum platelet antibodies and for human platelet antigen-1a (HPA-1a) phenotyping...
  98. ncbi request reprint Rapid detection of antibodies to immunoglobulin A molecules by using the particle gel immunoassay
    A Salama
    Blood Bank, Charite, Campus Virchow Clinic, Berlin, Germany
    Vox Sang 81:45-8. 2001
    ..Antibodies to immunoglobulin A (IgA) molecules are thought to be frequently responsible for anaphylactic reactions in transfusion medicine, but practical tests for the detection of antibodies to IgA are not yet available...
  99. ncbi request reprint Massive haemolysis after intramuscular diclofenac in a patient who apparently tolerated oral medication
    N Ahrens
    Institute for Transfusion Medicine, Charite University Medicine Berlin, Germany
    Vox Sang 86:71-4. 2004
    ..A relationship with oral or intramuscular drug administration is unknown. Here, we describe a patient who apparently tolerated oral diclofenac but developed severe IHA following intramuscular injection of the drug...
  100. ncbi request reprint [Preoperative identification of patients with impaired (primary) haemostasis. A practical concept]
    J Koscielny
    Universitatsmedizin Berlin, Charite, Institut für Transfusionmedizin, Gerinnungsambulanz, Campus Charite Mitte, Chariteplatz 1, 10117 Berlin
    Hamostaseologie 27:177-84. 2007
    ..Based on these data, national regards are formulated or under construction...