Wolfram Doehner

Summary

Affiliation: Humboldt University
Country: Germany

Publications

  1. doi request reprint Overweight and obesity are associated with improved survival, functional outcome, and stroke recurrence after acute stroke or transient ischaemic attack: observations from the TEMPiS trial
    Wolfram Doehner
    Center for Stroke Research Berlin, Charite Universitatsmedizin Berlin, Campus Virchow Klinikum, Germany
    Eur Heart J 34:268-77. 2013
  2. doi request reprint Inverse relation of body weight and weight change with mortality and morbidity in patients with type 2 diabetes and cardiovascular co-morbidity: an analysis of the PROactive study population
    Wolfram Doehner
    Center for Stroke Research Berlin, Charite, Berlin, Germany
    Int J Cardiol 162:20-6. 2012
  3. doi request reprint Improved insulin sensitivity by the angiotensin receptor antagonist irbesartan in patients with systolic heart failure: a randomized double-blinded placebo-controlled study
    Wolfram Doehner
    Center for Stroke Research Berlin, Charite Universitatsmedizin Berlin, Germany
    Int J Cardiol 161:137-42. 2012
  4. doi request reprint Elevated plasma levels of neuropeptide proenkephalin a predict mortality and functional outcome in ischemic stroke
    Wolfram Doehner
    Center for Stroke Research Berlin, Charite Universitatsmedizin Berlin, Germany
    J Am Coll Cardiol 60:346-54. 2012
  5. doi request reprint Xanthine oxidase and uric acid in cardiovascular disease: clinical impact and therapeutic options
    Wolfram Doehner
    Center for Stroke Research Berlin and Applied Cachexia Research, Department of Cardiology, Charite Universitatsmedizin Berlin, Berlin, Germany
    Semin Nephrol 31:433-40. 2011
  6. ncbi request reprint Impaired insulin sensitivity as an independent risk factor for mortality in patients with stable chronic heart failure
    Wolfram Doehner
    Department of Clinical Cardiology, National Heart and Lung Institute, Imperial College, London, United Kingdom
    J Am Coll Cardiol 46:1019-26. 2005
  7. ncbi request reprint Optimizing insulin sensitivity assessment using the minimal model in chronic heart failure
    W Doehner
    Applied Cachexia Research, Dept of Cardiology, Charite Medical School, Campus Virchow Klinikum, Humboldt University, Augustenburger Platz 1, 13353 Berlin, Germany
    Horm Metab Res 37:106-10. 2005
  8. ncbi request reprint Secretory sphingomyelinase is upregulated in chronic heart failure: a second messenger system of immune activation relates to body composition, muscular functional capacity, and peripheral blood flow
    Wolfram Doehner
    Division of Applied Cachexia Research, Department of Cardiology, Charite Medical School, Campus Virchow Klinikum, Berlin, Germany
    Eur Heart J 28:821-8. 2007
  9. doi request reprint Reduced glucose transporter GLUT4 in skeletal muscle predicts insulin resistance in non-diabetic chronic heart failure patients independently of body composition
    Wolfram Doehner
    Division of Applied Cachexia Research, Department of Cardiology, Charite, Campus Virchow Klinikum, Berlin, Germany
    Int J Cardiol 138:19-24. 2010
  10. ncbi request reprint Body mass and survival in patients with chronic heart failure without cachexia: the importance of obesity
    Constantinos H Davos
    Department of Cardiac Medicine, National Heart and Lung Institute, London, United Kingdom
    J Card Fail 9:29-35. 2003

Detail Information

Publications90

  1. doi request reprint Overweight and obesity are associated with improved survival, functional outcome, and stroke recurrence after acute stroke or transient ischaemic attack: observations from the TEMPiS trial
    Wolfram Doehner
    Center for Stroke Research Berlin, Charite Universitatsmedizin Berlin, Campus Virchow Klinikum, Germany
    Eur Heart J 34:268-77. 2013
    ..Obesity is an established risk factors in primary cardiovascular disease prevention including stroke. The impact of overweight in patients with stroke or TIA on secondary fatal and non-fatal functional outcomes is less well established...
  2. doi request reprint Inverse relation of body weight and weight change with mortality and morbidity in patients with type 2 diabetes and cardiovascular co-morbidity: an analysis of the PROactive study population
    Wolfram Doehner
    Center for Stroke Research Berlin, Charite, Berlin, Germany
    Int J Cardiol 162:20-6. 2012
    ..Although weight reduction is a recommended goal in type 2 diabetes mellitus (T2DM), weight loss is linked to impaired survival in patients with some chronic cardiovascular diseases...
  3. doi request reprint Improved insulin sensitivity by the angiotensin receptor antagonist irbesartan in patients with systolic heart failure: a randomized double-blinded placebo-controlled study
    Wolfram Doehner
    Center for Stroke Research Berlin, Charite Universitatsmedizin Berlin, Germany
    Int J Cardiol 161:137-42. 2012
    ..We aimed to test the ancillary metabolic effect of irbesartan on insulin sensitivity in patients with CHF...
  4. doi request reprint Elevated plasma levels of neuropeptide proenkephalin a predict mortality and functional outcome in ischemic stroke
    Wolfram Doehner
    Center for Stroke Research Berlin, Charite Universitatsmedizin Berlin, Germany
    J Am Coll Cardiol 60:346-54. 2012
    ..The purpose of this study was to investigate neuropeptides in patients presenting with symptoms of acute cerebrovascular disease...
  5. doi request reprint Xanthine oxidase and uric acid in cardiovascular disease: clinical impact and therapeutic options
    Wolfram Doehner
    Center for Stroke Research Berlin and Applied Cachexia Research, Department of Cardiology, Charite Universitatsmedizin Berlin, Berlin, Germany
    Semin Nephrol 31:433-40. 2011
    ..In this review we summarize current evidence on hyperuricemia in CVD. The value of UA as a biomarker and as a potential therapeutic target for tailored metabolic treatment in CVD is discussed...
  6. ncbi request reprint Impaired insulin sensitivity as an independent risk factor for mortality in patients with stable chronic heart failure
    Wolfram Doehner
    Department of Clinical Cardiology, National Heart and Lung Institute, Imperial College, London, United Kingdom
    J Am Coll Cardiol 46:1019-26. 2005
    ..The aim of this study was to determine the significance of insulin resistance as an independent risk factor for impaired prognosis in patients with chronic heart failure (CHF)...
  7. ncbi request reprint Optimizing insulin sensitivity assessment using the minimal model in chronic heart failure
    W Doehner
    Applied Cachexia Research, Dept of Cardiology, Charite Medical School, Campus Virchow Klinikum, Humboldt University, Augustenburger Platz 1, 13353 Berlin, Germany
    Horm Metab Res 37:106-10. 2005
    ..Continuing experience in minimal model methodology has raised questions about how best to assign basal glucose concentrations during such analyses...
  8. ncbi request reprint Secretory sphingomyelinase is upregulated in chronic heart failure: a second messenger system of immune activation relates to body composition, muscular functional capacity, and peripheral blood flow
    Wolfram Doehner
    Division of Applied Cachexia Research, Department of Cardiology, Charite Medical School, Campus Virchow Klinikum, Berlin, Germany
    Eur Heart J 28:821-8. 2007
    ....
  9. doi request reprint Reduced glucose transporter GLUT4 in skeletal muscle predicts insulin resistance in non-diabetic chronic heart failure patients independently of body composition
    Wolfram Doehner
    Division of Applied Cachexia Research, Department of Cardiology, Charite, Campus Virchow Klinikum, Berlin, Germany
    Int J Cardiol 138:19-24. 2010
    ..GLUT4, the predominant glucose transporter in the skeletal muscle promotes the rate-limiting step of glucose utilization in skeletal muscle. The significance of skeletal muscle GLUT4 in patients with CHF has not been studied in detail...
  10. ncbi request reprint Body mass and survival in patients with chronic heart failure without cachexia: the importance of obesity
    Constantinos H Davos
    Department of Cardiac Medicine, National Heart and Lung Institute, London, United Kingdom
    J Card Fail 9:29-35. 2003
    ..Cachexia in chronic heart failure carries a poor prognosis, but little is known about the influence of body mass on the prognosis of noncachectic heart failure patients...
  11. ncbi request reprint Uric acid and survival in chronic heart failure: validation and application in metabolic, functional, and hemodynamic staging
    Stefan D Anker
    Applied Cachexia Research Unit, Charite, Campus Virchow Klinikum, Berlin, Germany
    Circulation 107:1991-7. 2003
    ..Serum uric acid (UA) could be a valid prognostic marker and useful for metabolic, hemodynamic, and functional (MFH) staging in chronic heart failure (CHF)...
  12. doi request reprint Mid-regional pro-adrenomedullin as a novel predictor of mortality in patients with chronic heart failure
    Stephan von Haehling
    Applied Cachexia Research, Department of Cardiology, Charité Medical School Campus Virchow Klinikum, 13353 Berlin, Germany
    Eur J Heart Fail 12:484-91. 2010
    ..Adrenomedullin (ADM) is a vasodilatory peptide. Its plasma levels or its precursors have not been evaluated in large populations of patients with chronic heart failure (CHF). We sought to explore mid-regional proADM (MR-proADM)...
  13. doi request reprint Assessment of serum cotinine in patients with chronic heart failure: self-reported versus objective smoking behaviour
    Nicole Ebner
    Department of Cardiology, Applied Cachexia Research, Charite Medical School, Campus Virchow Klinikum, Augustenburger Platz 1, 13353, Berlin, Germany
    Clin Res Cardiol 102:95-101. 2013
    ..The value of self-reported smoking behaviour has not been validated in patients with HF. We sought to assess serum cotinine levels, a marker of recent tobacco exposure, in a cohort of clinically stable patients with chronic HF...
  14. ncbi request reprint The relationship between age and production of tumour necrosis factor-alpha in healthy volunteers and patients with chronic heart failure
    Stephan von Haehling
    Department of Clinical Cardiology, National Heart and Lung Institute, London SW3 6LY, UK
    Int J Cardiol 90:197-204. 2003
    ..Elevated plasma levels of tumour necrosis factor-alpha (TNF-alpha) are present in patients with advanced chronic heart failure (CHF). However, the relationship between age and the immune response in CHF is unknown...
  15. doi request reprint Mechanism and novel therapeutic approaches to wasting in chronic disease
    Nicole Ebner
    Applied Cachexia Research, Department of Cardiology, Charite University, Medical School, Campus Virchow Klinikum, Berlin, Germany
    Maturitas 75:199-206. 2013
    ..We discuss therapeutic targets and such potential modulators as appetite stimulants, selective androgen receptor modulators, amino acids and naturally occurring peptide hormones...
  16. doi request reprint Copeptin as a prognostic factor for major adverse cardiovascular events in patients with coronary artery disease
    Stephan von Haehling
    Applied Cachexia Research, Department of Cardiology, Charite Medical School, Campus Virchow Klinikum, Berlin, Germany
    Int J Cardiol 162:27-32. 2012
    ..The aim is to investigate the prognostic value of copeptin with regard to mortality and morbidity in patients with symptomatic coronary artery disease (CAD)...
  17. ncbi request reprint The relationship between cholesterol and survival in patients with chronic heart failure
    Mathias Rauchhaus
    Clinical Cardiology, National Heart and Lung Institute, Imperial College School of Medicine, London, United Kingdom
    J Am Coll Cardiol 42:1933-40. 2003
    ..We sought to describe the relationship between cholesterol and survival in patients with chronic heart failure (CHF)...
  18. pmc Value of serum pregnancy-associated plasma protein A for predicting cardiovascular events among patients presenting with cardiac chest pain
    Stephan von Haehling
    Division of Applied Cachexia Research, Department of Cardiology, Charite Medical School, Campus Virchow Klinikum, Berlin, Germany
    CMAJ 185:E295-303. 2013
    ..We assessed the value of PAPP-A for predicting short-term cardiovascular events in a large cohort of patients presenting with cardiac chest pain...
  19. doi request reprint Inhibition of xanthine oxidase reduces wasting and improves outcome in a rat model of cancer cachexia
    Jochen Springer
    Department of Cardiology, Applied Cachexia Research, Charite Medical School, Berlin, Germany
    Int J Cancer 131:2187-96. 2012
    ..Food intake and spontaneous locomotor activity were higher, indicating a higher quality of life. Inhibition of XO can reduce tissue wasting and improve survival in cancer cachexia and clearly clinical studies are needed...
  20. doi request reprint Mid-regional pro-atrial natriuretic peptide as a prognostic marker for all-cause mortality in patients with symptomatic coronary artery disease
    Stephan von Haehling
    Applied Cachexia Research, Department of Cardiology, Charite Medical School, Campus Virchow Klinikum, Berlin, Germany
    Clin Sci (Lond) 123:601-10. 2012
    ..0001). MR-proANP may help in the prediction of all-cause death in patients with symptomatic CAD. Further studies should verify its prognostic value and confirm the appropriate cut-off value...
  21. ncbi request reprint Heat shock protein 70 in patients with chronic heart failure: relation to disease severity and survival
    Sabine Genth-Zotz
    Clinical Cardiology, National Heart and Lung Institute, Imperial College School of Medicine, London, UK
    Int J Cardiol 96:397-401. 2004
    ..We hypothesised that circulating Hsp70 levels are elevated in patients with CHF, more so in cachechtic patients, and that Hsp70 levels would relate to mortality...
  22. ncbi request reprint Uric acid in chronic heart failure
    Wolfram Doehner
    Division of Applied Cachexia Research, Department of Cardiology, Charite Medical School, Humboldt University, D 13353 Berlin, Germany
    Semin Nephrol 25:61-6. 2005
    ..In this article, the significance of the xanthine oxidase metabolic pathway in CHF is discussed. Data on xanthine oxidase inhibition are reviewed, which suggest a beneficial effect of therapeutically targeting this enzymatic pathway...
  23. doi request reprint Usefulness of minimal modelling to assess impaired insulin sensitivity in patients with chronic heart failure
    Tibor Szabo
    Applied Cachexia Research, Department of Cardiology, Campus Virchow Klinikum, Charite University Medical School, Berlin, Germany
    Int J Cardiol 147:47-51. 2011
    ..Their value and discriminatory power in comparison to dynamic range assessment of Si by minimal modelling are not well established...
  24. doi request reprint Studies on bacterial endotoxin and intestinal absorption function in patients with chronic heart failure
    Anja Sandek
    Dept of Cardiology, Charite Universitatsmedizin, Berlin, Germany
    Int J Cardiol 157:80-5. 2012
    ..Small intestinal function may be altered in decompensated chronic heart failure (CHF) and translocating LPS may contribute to systemic inflammation observed in CHF...
  25. doi request reprint Ursodeoxycholic acid in patients with chronic heart failure: a double-blind, randomized, placebo-controlled, crossover trial
    Stephan von Haehling
    Applied Cachexia Research, Department of Cardiology, Charite Medical School, Campus Virchow Klinikum, Berlin, Germany
    J Am Coll Cardiol 59:585-92. 2012
    ..This study sought to assess the effects of ursodeoxycholic acid (UDCA) on endothelial function and inflammatory markers in patients with chronic heart failure (CHF)...
  26. doi request reprint Endothelial dysfunction of the peripheral vascular bed in the acute phase after ischemic stroke
    Nadja Scherbakov
    Center for Stroke Research Berlin, Charite Universitatsmedizin Berlin, Berlin, Germany
    Cerebrovasc Dis 33:37-46. 2012
    ..Increased levels of ADMA have been found in chronic heart failure (CHF). We hypothesized that peripheral ED in acute ischemic stroke is associated with increased ADMA levels...
  27. doi request reprint Muscle wasting in patients with chronic heart failure: results from the studies investigating co-morbidities aggravating heart failure (SICA-HF)
    Susann Fülster
    Department of Cardiology, Applied Cachexia Research, Charite Medical School, Campus Virchow Klinikum, Augustenburger Platz 1, 13353, Berlin, Germany
    Eur Heart J 34:512-9. 2013
    ..To assess the prevalence and clinical impact of reductions in the skeletal muscle mass of patients with chronic heart failure (HF). Chronic HF is accompanied by co-morbidities that influence the quality of life and outcomes...
  28. ncbi request reprint Effects of xanthine oxidase inhibition with allopurinol on endothelial function and peripheral blood flow in hyperuricemic patients with chronic heart failure: results from 2 placebo-controlled studies
    Wolfram Doehner
    Clinical Cardiology, National Heart and Lung Institute, Imperial College School of Medicine, London, UK
    Circulation 105:2619-24. 2002
    ..We therefore studied the effects of XO inhibition with allopurinol on endothelial function and peripheral blood flow in CHF patients after intra-arterial infusion and after oral administration in 2 independent placebo-controlled studies...
  29. doi request reprint The relationship between tumor necrosis factor-α, brain natriuretic peptide and atrial natriuretic peptide in patients with chronic heart failure
    Amalia Vaz Pérez
    Competence Network Heart Failure, Department of Cardiology, Campus Virchow Klinikum, Charite Universitatsmedizin Berlin, Berlin, Germany
    Int J Cardiol 141:39-43. 2010
    ..Brain natriuretic peptide (BNP) and atrial natriuretic peptide (ANP) are thought to reflect cardiac functional and structural damage...
  30. ncbi request reprint Insulin resistance in moderate chronic heart failure is related to hyperleptinaemia, but not to norepinephrine or TNF-alpha
    Wolfram Doehner
    Department of Clinical Cardiology, National Heart and Lung Institute, Imperial College School of Medicine, Dovehouse St, London SW3 6LY, UK
    Int J Cardiol 83:73-81. 2002
    ..The purpose of this study was to examine in patients with CHF and in comparison to healthy controls subjects whether norepinephrine, TNFalpha or leptin relate to insulin sensitivity...
  31. doi request reprint Cardiac cachexia is associated with right ventricular failure and liver dysfunction
    Miroslava Valentová
    Applied Cachexia Research, Department of Cardiology, Charite Medical School, Campus Virchow Klinikum, Berlin, Germany 1st Department of Internal Medicine, Faculty Hospital, Bratislava, Slovak Republic Electronic address
    Int J Cardiol 169:219-24. 2013
    ..The mechanisms involved in cardiac cachexia remain poorly understood. We examined the association of right ventricular (RV) and hepatic dysfunction with cardiac cachexia...
  32. pmc Leukocyte redistribution: effects of beta blockers in patients with chronic heart failure
    Stephan von Haehling
    Applied Cachexia Research, Dept of Cardiology, Charite Medical School, Campus Virchow Clinic, Berlin, Germany
    PLoS ONE 4:e6411. 2009
    ..Here we investigate whether a leukocyte redistribution occurs in CHF and whether this effect is influenced by beta-blocker therapy...
  33. doi request reprint Anaemia is an independent predictor of death in patients hospitalized for acute heart failure
    Stephan von Haehling
    Applied Cachexia Research, Department of Cardiology, Charite Medical School, Campus Virchow Klinikum, Augustenburger Platz 1, 13353 Berlin, Germany
    Clin Res Cardiol 99:107-13. 2010
    ..Acute heart failure is associated with a poor prognosis. It is important to identify patients at increased risk of adverse events. The presence of anaemia could help in this regard...
  34. ncbi request reprint Anorexia in chronic obstructive pulmonary disease--association to cachexia and hormonal derangement
    Friedrich Koehler
    Department of Cardiology, Charite University Hospital, Campus Mitte, Berlin, Germany
    Int J Cardiol 119:83-9. 2007
    ..Anorexia may importantly contribute to weight loss in COPD, however, the association between immune and hormonal derangement and altered appetite has not been studied in detail...
  35. doi request reprint Exercise capacity and body composition in living-donor renal transplant recipients over time
    Dirk Habedank
    Department Cardiology, Applied Cachexia Research, Charite Campus Virchow Klinikum, Berlin, Germany
    Nephrol Dial Transplant 24:3854-60. 2009
    ..Renal transplantation (RTx) restitutes the function of the failing organ and induces convalescence of the entire organism. Our study investigates whether this is accompanied by improvements in cardiovascular function and structural changes...
  36. ncbi request reprint The cardiac component of cardiac cachexia
    Viorel G Florea
    Department of Cardiac Medicine, National Heart and Lung Institute, London, United Kingdom
    Am Heart J 144:45-50. 2002
    ..This study sought to assess the cardiac dimensions, mass, and function and changes in these parameters over time in patients with chronic heart failure with and without cachexia...
  37. doi request reprint Resting energy expenditure and the effects of muscle wasting in patients with chronic heart failure: results from the Studies Investigating Comorbidities Aggravating Heart Failure (SICA-HF)
    Matthias Tacke
    Applied Cachexia Research, Department of Cardiology, Charite Medical School, Campus Virchow Klinikum, Berlin, Germany
    J Am Med Dir Assoc 14:837-41. 2013
    ..Glucagonlike peptide 1 (GLP-1) is linked to REE in healthy individuals. We aimed to evaluate (1) whether REE is elevated in patients with HF with muscle wasting, and (2) whether basal GLP-1 levels are linked to REE in HF...
  38. pmc The influence of recovery and training phases on body composition, peripheral vascular function and immune system of professional soccer players
    Simon Reinke
    Division of Applied Cachexia Research, Department of Cardiology, Charite Universitatsmedizin Berlin, CVK, Berlin, Germany
    PLoS ONE 4:e4910. 2009
    ....
  39. doi request reprint Absolute and functional iron deficiency in professional athletes during training and recovery
    Simon Reinke
    Division of Applied Cachexia Research, Department of Cardiology, Charite Universitatsmedizin Berlin, Germany
    Int J Cardiol 156:186-91. 2012
    ..We hypothesised that physical extremes result in ID in elite athletes and that the short recovery period may be insufficient to allow a lasting replenishment of iron reserves...
  40. doi request reprint Neurohormonal activation and inflammation in chronic cardiopulmonary disease: a brief systematic review
    Wolfram Doehner
    Center for Stroke Research Berlin, Charite, Berlin, Germany
    Wien Klin Wochenschr 121:293-6. 2009
    ..Retrospective and epidemiological data for their beneficial effect in chronic obstructive pulmonary disease begin to accumulate and new fields (e.g. cancer and stroke) could be pending in the future...
  41. doi request reprint Hormonal consequences and prognosis of chronic heart failure
    Philipp Attanasio
    Department of Cardiology, Charite Medical School, Campus Virchow Klinikum, Berlin, Germany
    Curr Opin Endocrinol Diabetes Obes 18:224-30. 2011
    ..This review aims to highlight players of the catabolic-anabolic imbalance, regulators or appetite, and other mediators that are involved in the progression of CHF to cachexia...
  42. doi request reprint Inflammatory biomarkers in heart failure revisited: much more than innocent bystanders
    Stephan von Haehling
    Department of Cardiology, Applied Cachexia Research, Charite Medical School, Berlin, Germany
    Heart Fail Clin 5:549-60. 2009
    ..In addition to these acute phase reactants, several adhesion molecules, and lipopolysaccharide-signaling pathways are discussed...
  43. ncbi request reprint Effect of interleukin-10 on the production of tumor necrosis factor-alpha by peripheral blood mononuclear cells from patients with chronic heart failure
    Aidan P Bolger
    Clinical Cardiology, National Heart and Lung Institute, Imperial College School of Medicine, London, United Kingdom
    Am J Cardiol 90:384-9. 2002
    ..IL-10 is, therefore, a potential therapy for use in chronic HF associated with inflammatory immune activation...
  44. doi request reprint Nutrition in heart failure: an update
    Anja Sandek
    Applied Cachexia Research, Department of Cardiology, Charite Medical School, Berlin, Germany
    Curr Opin Clin Nutr Metab Care 12:384-91. 2009
    ..Chronic heart failure (CHF) is increasingly recognized as a multisystem disease with important comorbidities such as anemia, insulin resistance, autonomic dysbalance, or cardiac cachexia...
  45. ncbi request reprint Association of deranged adrenal steroid metabolism with anemia in chronic heart failure
    Darlington O Okonko
    Clinical Cardiology, National Heart and Lung Institute, Imperial College, London, UK
    Am J Cardiol 96:101-3. 2005
    ..The cortisol/DHEA ratio was independently and inversely associated with hemoglobin concentrations, suggesting that alterations of the steroid milieu may play a role in the pathogenesis of anemia in CHF...
  46. ncbi request reprint Altered intestinal function in patients with chronic heart failure
    Anja Sandek
    Department of Gastroenterology, Charite, Campus Mitte, Berlin, Germany
    J Am Coll Cardiol 50:1561-9. 2007
    ..We evaluated morphology and function of the gut in patients with chronic heart failure (CHF)...
  47. pmc Non-invasive assessment of cardiac hemodynamics in patients with advanced cancer and with chronic heart failure: a pilot feasibility study
    Stephan von Haehling
    Applied Cachexia Research, Department of Cardiology, Charite Medical School, Campus Virchow Klinikum, Berlin, Germany Center for Cardiovascular Research CCR, Charite Medical School, Campus Mitte, Berlin, Germany
    Arch Med Sci 9:261-7. 2013
    ..Using the novel Nexfin Finapres technique, we sought to assess measures of cardiac performance in patients with cancer and compare these values with those from control subjects and patients with chronic HF...
  48. doi request reprint Risk stratification in patients with chronic heart failure based on metabolic-immunological, functional and haemodynamic parameters
    Ralph Herrmann
    Department of Cardiology, Charite Medical School, Campus Virchow Klinikum, Berlin, Germany
    Int J Cardiol 156:62-8. 2012
    ..A vast array of parameters has been proposed to predict mortality in chronic heart failure (CHF). Their applicability into clinical practice remains challenging due to economical and availability considerations...
  49. ncbi request reprint Comparison of midregional pro-atrial natriuretic peptide with N-terminal pro-B-type natriuretic peptide in predicting survival in patients with chronic heart failure
    Stephan von Haehling
    Applied Cachexia Research, Department of Cardiology, Charite Medical School, Berlin, Germany
    J Am Coll Cardiol 50:1973-80. 2007
    ..Our aim was assess the prognostic value of midregional pro-atrial natriuretic peptide (MR-proANP) using a new immunoassay in patients with chronic heart failure (HF)...
  50. ncbi request reprint Nutrition, metabolism, and the complex pathophysiology of cachexia in chronic heart failure
    Stephan von Haehling
    Department of Clinical Cardiology, Imperial College School of Medicine, National Heart and Lung Institute, Dovehouse Street, London, SW3 6LY, UK
    Cardiovasc Res 73:298-309. 2007
    ..Finally, therapeutic approaches are discussed. These include dietary advice, ongoing studies, and future possibilities...
  51. ncbi request reprint Wasting of the left ventricle in patients with cardiac cachexia: a cardiovascular magnetic resonance study
    Viorel G Florea
    Department of Clinical Cardiology, Imperial College of Science, National Heart and Lung Institute, Dovehouse Street, London SW3 6LY, UK
    Int J Cardiol 97:15-20. 2004
    ..Cardiovascular magnetic resonance (CMR) has high reproducibility and is more sensitive than other techniques...
  52. doi request reprint The xanthine oxidase inhibitor oxypurinol reduces cancer cachexia-induced cardiomyopathy
    Jochen Springer
    Applied Cachexia Research, Department of Cardiology, Charite Medical School, Berlin, Germany Center for Cardiovascular Research, Charite Medical School, Berlin, Germany Norwich Medical School, University of East Anglia, Norwich, UK Electronic address
    Int J Cardiol 168:3527-31. 2013
    ..Xanthine oxidase (XO) metabolizes purines to uric acid and its inhibition has been shown to improve clinical outcome in patients with chronic heart failure...
  53. doi request reprint Tandospirone reduces wasting and improves cardiac function in experimental cancer cachexia
    Yulia Elkina
    Applied Cachexia Research, Department of Cardiology, Charite Medical School, Berlin, Germany Center for Cardiovascular Research, Charite Medical School, Berlin, Germany
    Int J Cardiol 170:160-6. 2013
    ..Here, we characterize the effects of the antidepressant and anxiolytic drug tandospirone on wasting, cardiac function and survival in experimental cancer cachexia...
  54. doi request reprint Simvastatin reduces wasting and improves cardiac function as well as outcome in experimental cancer cachexia
    Sandra Palus
    Applied Cachexia Research, Department of Cardiology, Charite Medical School, Berlin, Germany Center for Cardiovascular Research, Charite Medical School, Berlin, Germany
    Int J Cardiol 168:3412-8. 2013
    ..Recently, several groups have described a form of cardiomyopathy in CC animal models. Hence, we investigated the effect of simvastatin with its known anti-inflammatory and cardioprotective effects in a rat model of CC...
  55. doi request reprint Furosemide induces mortality in a rat model of chronic heart failure
    Hirofumi Rokutan
    Center for Cardiovascular Research, Charite Medical School, Campus Mitte, Berlin, Germany
    Int J Cardiol 160:20-5. 2012
    ..In an experimental heart failure model, we tested the hypothesis that furosemide causes excess mortality...
  56. doi request reprint Liver dysfunction and its nutritional implications in heart failure
    Miroslava Valentová
    Applied Cachexia Research, Department of Cardiology, Charite Medical School, Campus Virchow Klinikum, Berlin, Germany
    Nutrition 29:370-8. 2013
    ..Nutritional strategies opposing these deficiencies might present promising additive treatments of heart failure...
  57. doi request reprint Novel treatment approaches to cachexia and sarcopenia: highlights from the 5th Cachexia Conference
    Thomas Kung
    Applied Cachexia Research, Charite Medical School, Department of Cardiology, Campus Virchow Klinikum, Augustenburger Platz 1, D 13353 Berlin, Germany
    Expert Opin Investig Drugs 19:579-85. 2010
    ..Novel therapeutic approaches shown here include melanocortin-4 receptor antagonists, myostatin inhibition, beta-blockers, IL-6 antagonism synthetic ghrelin and vitamin D...
  58. doi request reprint Overview of emerging pharmacotherapy in chronic heart failure
    Tibor Szabo
    Charite Medical School, Campus Virchow Klinikum, Applied Cachexia Research, Department of Cardiology, Augustenburger Platz 1, 13353 Berlin, Germany
    Expert Opin Pharmacother 10:2055-74. 2009
    ..This review will focus on recent developments and potential future candidates of pharmacological CHF therapy...
  59. doi request reprint Increased catabolic activity in adipose tissue of patients with chronic heart failure
    Tibor Szabo
    Charite University Medicine, Campus Virchow Klinikum, Department of Cardiology, Applied Cachexia Research, Berlin, Germany
    Eur J Heart Fail 15:1131-7. 2013
    ..We tested the hypothesis that increased plasma ANP levels are associated with an increased catabolic (lipolytic) state of white AT in patients with CHF...
  60. doi request reprint Stroke induced Sarcopenia: muscle wasting and disability after stroke
    Nadja Scherbakov
    Centre for Stroke Research Berlin, Charite Universitatsmedizin Berlin, Germany
    Int J Cardiol 170:89-94. 2013
    ..This review provides an overview on current pathophysiologic insights and on clinical relevance of sarcopenia in stroke patients and on measurement tools to address the problem in the clinical setting. ..
  61. doi request reprint Effect of application route of the ghrelin analog BIM-28131 (RM-131) on body weight and body composition in a rat heart failure model
    Sandra Palus
    Applied Cachexia Research, Dept of Cardiology, Charite Medical School, Berlin, Germany Center for Cardiovascular Research, Charite Medical School, Berlin, Germany
    Int J Cardiol 168:2369-74. 2013
    ..Little effect was seen on cardiac function; only cardiac output was improved by either high dose BIM-28131 or GH. Overall the effects of BIM-28131 were similar in both application routes...
  62. doi request reprint Neurological and endocrinological disorders: orphans in chronic obstructive pulmonary disease
    Wolfram Doehner
    Center for Stroke Research Berlin, Charite Medical School, Berlin, Germany
    Respir Med 105:S12-9. 2011
    ..Impaired glucose metabolism ranges from insulin resistance to overt diabetes mellitus, which is a frequent finding and is associated with worse outcome...
  63. ncbi request reprint Anemia and inflammation in COPD
    Matthias John
    Department of Pneumology, University Hospital Charite, Campus Mitte, Schumannstr 20 21, 10098 Berlin, Germany
    Chest 127:825-9. 2005
    ..Anemia in patients with COPD and its pathophysiology is an understudied issue...
  64. pmc Titration to target dose of bisoprolol vs. carvedilol in elderly patients with heart failure: the CIBIS-ELD trial
    Hans Dirk Düngen
    Department of Internal Medicine Cardiology, Charite Universitatsmedizin, Competence Network Heart Failure, Campus Virchow Klinkum, Berlin, Germany
    Eur J Heart Fail 13:670-80. 2011
    ..The aim of this study was therefore to compare the tolerability and clinical effects of two proven beta-blockers in elderly patients with heart failure...
  65. doi request reprint Impaired insulin sensitivity as an underlying mechanism linking hepatitis C and posttransplant diabetes mellitus in kidney recipients
    S Baid-Agrawal
    Division of Nephrology and Medical Intensive Care, Department of Medicine, Berlin, Germany
    Am J Transplant 9:2777-84. 2009
    ....
  66. doi request reprint Muscle wasting in heart failure: An overview
    Stephan von Haehling
    Applied Cachexia Research, Department of Cardiology, Charite Medical School, Campus Virchow Klinikum, Berlin, Germany
    Int J Biochem Cell Biol 45:2257-65. 2013
    ..This article is part of a Directed Issue entitled: Molecular basis of muscle wasting. ..
  67. pmc Down-regulation of endothelial TLR4 signalling after apo A-I gene transfer contributes to improved survival in an experimental model of lipopolysaccharide-induced inflammation
    Sophie Van Linthout
    Department of Cardiology and Pneumology, Charite University Medicine Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12200, Berlin, Germany
    J Mol Med (Berl) 89:151-60. 2011
    ..In conclusion, HDL reduces TLR4 expression and signalling in endothelial cells, which may contribute significantly to the protective effects of HDL in LPS-induced inflammation and lethality...
  68. doi request reprint Body weight after stroke: lessons from the obesity paradox
    Nadja Scherbakov
    Center for Stroke Research Berlin, Department of Neurology and Experimental Neurology, Charite Universitatsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
    Stroke 42:3646-50. 2011
    ..Key mechanisms of stroke pathophysiology can induce systemic catabolic imbalance with impaired metabolic efficiency and degradation of body tissues...
  69. ncbi request reprint World Congress of Cardiology 2006. Barcelona, Spain, September 2-5, 2006
    Wolfram Doehner
    Department of Cardiology, Charite Medical School, Campus Virchow Hospital, Berlin, Germany
    Heart Fail Monit 5:97-100. 2007
  70. ncbi request reprint Low-dose treatment with atorvastatin leads to anti-oxidative and anti-inflammatory effects in diabetes mellitus
    Alexander Riad
    Department of Cardiology and Pneumology, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12206 Berlin, Germany
    Eur J Pharmacol 569:204-11. 2007
    ..05). Lipid-independent anti-oxidative and anti-inflammatory effects of low-dose atorvastatin involving the ERK1/2/NF-kappaB-pathway are sufficient to improve endothelial function under experimental diabetic conditions...
  71. ncbi request reprint Meeting report from the 74th annual scientific sessions of the American Heart Association (AHA). Anaheim, CA, USA, November 11-14, 2001
    Wolfram Doehner
    Department of Clinical Cardiology, National Heart and Lung Institute, Imperial College School of Medicine, London, UK
    Heart Fail Monit 2:104-7. 2002
  72. ncbi request reprint Cardiac cachexia in early literature: a review of research prior to Medline
    Wolfram Doehner
    Department of Clinical Cardiology, NHLI, Imperial College School of Medicine, London, UK
    Int J Cardiol 85:7-14. 2002
    ..This review presents an overview of early thoughts and milestone studies on metabolic abnormalities and cachexia in chronic heart failure...
  73. ncbi request reprint Leptin, insulin sensitivity and growth hormone binding protein in chronic heart failure with and without cardiac cachexia
    W Doehner
    Department of Clinical Cardiology, NHLI, Imperial College School of Medicine, London, UK
    Eur J Endocrinol 145:727-35. 2001
    ..This study aimed to examine the influence of leptin on GHBP in CHF patients with and without cardiac cachexia compared with healthy control subjects...
  74. pmc Intensified secondary prevention intending a reduction of recurrent events in TIA and minor stroke patients (INSPiRE-TMS): a protocol for a randomised controlled trial
    Stefanie Leistner
    Department of Neurology, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12203, Berlin, Germany
    BMC Neurol 13:11. 2013
    ..INSPiRE-TMS is a prospective, multi-center, randomized open intervention trial for intensified secondary prevention after minor stroke and TIA...
  75. doi request reprint Elevated levels of asymmetric dimethylarginine in chronic heart failure: a pathophysiologic link between oxygen radical load and impaired vasodilator capacity and the therapeutic effect of allopurinol
    S von Haehling
    Applied Cachexia Research, Department of Cardiology, Charite Medical School, Campus Virchow Klinikum, Berlin, Germany
    Clin Pharmacol Ther 88:506-12. 2010
    ..02); postischemic vasodilation as well as endothelium-dependent vasodilation (both P < 0.05) improved. ADMA may be a pathophysiologic factor that is modulated by ROS accumulation and contributes to impaired vascular regulation in CHF...
  76. ncbi request reprint Anemia in chronic heart failure--frequency and prognostic impact
    W Steinborn
    Imperial College, NHLI, Department of Clinical Cardiology, London, UK
    Clin Nephrol 60:S103-7. 2003
    ..However, the anemia seen in CHF is generally an "anemia of chronic illness". Furthermore, it has been shown that hemoglobin levels independently predict increased mortality in CHF...
  77. ncbi request reprint Plasma cytokine parameters and mortality in patients with chronic heart failure
    M Rauchhaus
    Clinical Cardiology, National Heart and Lung Institute, Royal Brompton Hospital, London, UK
    Circulation 102:3060-7. 2000
    ..Little is known about the prognostic importance of tumor necrosis factor-alpha (TNF-alpha), soluble TNF-receptor 1 and 2 (sTNF-R1/sTNF-R2), interleukin-6 (IL-6), and soluble CD14 receptors (sCD14) in CHF patients...
  78. ncbi request reprint Anemia in chronic heart failure--clinical and prognostic significance
    T Karhausen
    Div of Applied Cachexia Research, Dept of Cardiology, Charite, Campus Virchow Klinikum, Augustenburger Platz 1, 13353 Berlin, Germany
    Curr Med Chem Cardiovasc Hematol Agents 3:297-303. 2005
    ..The option of therapeutically targeting anemia in CHF is an intriguing novel approach to improve morbidity and potentially mortality in these patients...
  79. ncbi request reprint Acquired growth hormone resistance in patients with chronic heart failure: implications for therapy with growth hormone
    S D Anker
    Franz Volhard Klinik, Max Delbrück Centrum for Molecular Medicine, Charite, Berlin, Germany
    J Am Coll Cardiol 38:443-52. 2001
    ..We aimed to determine whether growth hormone (GH) resistance is present in patients with chronic heart failure (CHF) and whether it may be linked to the biochemical response to GH treatment...
  80. ncbi request reprint Chronic heart failure in the very elderly: clinical status, survival, and prognostic factors in 188 patients more than 70 years old
    M Cicoira
    Department of Cardiac Medicine, National Heart and Lung Institute, London, United Kingdom
    Am Heart J 142:174-80. 2001
    ..There are no data on the prognostic value of cardiopulmonary exercise testing in this population. We aimed to assess exercise capacity, survival, and prognostic parameters in elderly patients with CHF...
  81. ncbi request reprint Prediction of mortality in chronic heart failure from peak oxygen consumption adjusted for either body weight or lean tissue
    Mariantonietta Cicoira
    Divisione Clinicizzata di Cardiologia, Universita degli Studi di Verona, Italy
    J Card Fail 10:421-6. 2004
    ..We hypothesized that correcting pVO2 for lean tissue rather than total body weight would improve the prediction of prognosis in patients with chronic heart failure (CHF)...
  82. ncbi request reprint Clinical characteristics and survival of patients with chronic heart failure and prolonged QRS duration
    Paul R Kalra
    Clinical Cardiology, National Heart and Lung Institute, Dovehouse Street, London SW3 6LY, UK
    Int J Cardiol 86:225-31. 2002
    ..Whilst resynchronisation of ventricular conduction may benefit patients with QRS>150 ms, this has yet to be determined for patients with moderate QRS prolongation...
  83. doi request reprint Insulin resistance in chronic heart failure
    Wolfram Doehner
    J Am Coll Cardiol 52:239; author reply 239-40. 2008
  84. ncbi request reprint Whole blood endotoxin responsiveness in patients with chronic heart failure: the importance of serum lipoproteins
    Rakesh Sharma
    Clinical Cardiology, NHLI, Imperial College School of Medicine, Dovehouse Street, SW3 6LY, London, UK
    Eur J Heart Fail 7:479-84. 2005
    ..We sought to investigate the relationship between whole blood endotoxin responsiveness and serum lipoprotein concentrations. It is not known if low-dose LPS is sufficient to stimulate immune activation...
  85. ncbi request reprint Cellular endotoxin desensitization in patients with severe chronic heart failure
    Rakesh Sharma
    Clinical Cardiology, NHLI, Imperial College School of Medicine, London, UK
    Eur J Heart Fail 7:865-8. 2005
    ..It is not known if LPS desensitization occurs in CHF...
  86. ncbi request reprint Prognostic utility of growth differentiation factor-15 in patients with chronic heart failure
    Tibor Kempf
    Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany
    J Am Coll Cardiol 50:1054-60. 2007
    ..We explored the prognostic utility of growth differentiation factor (GDF)-15 in patients with chronic heart failure (CHF)...
  87. ncbi request reprint Heart failure therapy: testosterone replacement and its implications
    Mathias Rauchhaus
    Eur Heart J 27:10-2. 2006
  88. ncbi request reprint Questions in cardiac resynchronization therapy: metabolic implications
    Tim Karhausen
    J Am Coll Cardiol 48:591-2; author reply 592. 2006
  89. ncbi request reprint Survival and body fat in hemodialysis patients: true association or effects of concomitant therapy?
    Anja Sandek
    Am J Clin Nutr 84:663-4; author reply 634. 2006
  90. ncbi request reprint Metabolic disturbances in chronic heart failure: a case for the "macho" approach with testosterone?!
    Mitja Lainscak
    Eur J Heart Fail 9:2-3. 2007
    ..We discuss this study in detail. Further studies are needed to substantiate this link and to generally explore the value of testosterone therapy in CHF patients...