M Dietel

Summary

Affiliation: Humboldt University
Country: Germany

Publications

  1. pmc CognitionMaster: an object-based image analysis framework
    Stephan Wienert
    Institute of Pathology, Charite University Hospital Berlin, Chariteplatz 1, Berlin, 10117, Germany
    Diagn Pathol 8:34. 2013
  2. pmc Remodeling of central metabolism in invasive breast cancer compared to normal breast tissue - a GC-TOFMS based metabolomics study
    Jan Budczies
    Institute of Pathology, Charite University Hospital, 10117 Berlin, Germany
    BMC Genomics 13:334. 2012
  3. pmc Differential expression of histone deacetylases HDAC1, 2 and 3 in human breast cancer--overexpression of HDAC2 and HDAC3 is associated with clinicopathological indicators of disease progression
    Berit Maria Müller
    Institute of Pathology, Charite University Hospital, Campus Mitte, Chariteplatz 1, 10117 Berlin, Germany
    BMC Cancer 13:215. 2013
  4. pmc Decentral gene expression analysis: analytical validation of the Endopredict genomic multianalyte breast cancer prognosis test
    Ralf Kronenwett
    Sividon Diagnostics GmbH, Nattermannallee 1, 50829, Cologne, Germany
    BMC Cancer 12:456. 2012
  5. doi request reprint Predictive molecular pathology and its role in targeted cancer therapy: a review focussing on clinical relevance
    M Dietel
    Institute of Pathology, Charite, University Medicine Berlin, Berlin, Germany
    Cancer Gene Ther 20:211-21. 2013
  6. pmc Metabolite profiling of human colon carcinoma--deregulation of TCA cycle and amino acid turnover
    Carsten Denkert
    Institute of Pathology, Charite University Hospital, 10117 Berlin, Germany
    Mol Cancer 7:72. 2008
  7. pmc Identification of biology-based breast cancer types with distinct predictive and prognostic features: role of steroid hormone and HER2 receptor expression in patients treated with neoadjuvant anthracycline/taxane-based chemotherapy
    Silvia Darb-Esfahani
    Institute of Pathology, Charite Universitatsmedizin Berlin, Chariteplatz 1, Berlin, 10117, Germany
    Breast Cancer Res 11:R69. 2009
  8. pmc GOLPH2 expression in renal cell cancer
    Florian Rudolf Fritzsche
    Institute of Surgical Pathology, Universitatsspital Zurich, Zurich, Switzerland
    BMC Urol 8:15. 2008
  9. pmc GOLPH2 expression may serve as diagnostic marker in seminomas
    Florian R Fritzsche
    Institute of Surgical Pathology, Universitäts Spital Zürich, Zurich, Switzerland
    BMC Urol 10:4. 2010
  10. pmc An intracellular targeted antibody detects EGFR as an independent prognostic factor in ovarian carcinomas
    Aurelia Noske
    Institute of Pathology, University Hospital Charite Berlin, Germany
    BMC Cancer 11:294. 2011

Collaborators

Detail Information

Publications174 found, 100 shown here

  1. pmc CognitionMaster: an object-based image analysis framework
    Stephan Wienert
    Institute of Pathology, Charite University Hospital Berlin, Chariteplatz 1, Berlin, 10117, Germany
    Diagn Pathol 8:34. 2013
    ..However, most of the approaches rely on pixel-wise operations, a concept that has limitations when high-level object features and relationships between objects are studied and if user-interactivity on the object-level is desired...
  2. pmc Remodeling of central metabolism in invasive breast cancer compared to normal breast tissue - a GC-TOFMS based metabolomics study
    Jan Budczies
    Institute of Pathology, Charite University Hospital, 10117 Berlin, Germany
    BMC Genomics 13:334. 2012
    ..However, the metabolic changes between invasive carcinoma and normal breast tissues were not investigated in a large cohort of breast cancer samples so far...
  3. pmc Differential expression of histone deacetylases HDAC1, 2 and 3 in human breast cancer--overexpression of HDAC2 and HDAC3 is associated with clinicopathological indicators of disease progression
    Berit Maria Müller
    Institute of Pathology, Charite University Hospital, Campus Mitte, Chariteplatz 1, 10117 Berlin, Germany
    BMC Cancer 13:215. 2013
    ..An increased deacetylation of histones leads to increased cell proliferation, cell migration, angiogenesis and invasion. Class 1 histone deacetylases (HDAC) seem to be most important during carcinogenesis...
  4. pmc Decentral gene expression analysis: analytical validation of the Endopredict genomic multianalyte breast cancer prognosis test
    Ralf Kronenwett
    Sividon Diagnostics GmbH, Nattermannallee 1, 50829, Cologne, Germany
    BMC Cancer 12:456. 2012
    ..The aim of this study was the analytical validation of the performance characteristics of the assay and its verification in a molecular-pathological routine laboratory...
  5. doi request reprint Predictive molecular pathology and its role in targeted cancer therapy: a review focussing on clinical relevance
    M Dietel
    Institute of Pathology, Charite, University Medicine Berlin, Berlin, Germany
    Cancer Gene Ther 20:211-21. 2013
    ....
  6. pmc Metabolite profiling of human colon carcinoma--deregulation of TCA cycle and amino acid turnover
    Carsten Denkert
    Institute of Pathology, Charite University Hospital, 10117 Berlin, Germany
    Mol Cancer 7:72. 2008
    ..However, in contrast to genomics and proteomics, comprehensive metabolomic investigations of alterations in malignant tumors have rarely been conducted...
  7. pmc Identification of biology-based breast cancer types with distinct predictive and prognostic features: role of steroid hormone and HER2 receptor expression in patients treated with neoadjuvant anthracycline/taxane-based chemotherapy
    Silvia Darb-Esfahani
    Institute of Pathology, Charite Universitatsmedizin Berlin, Chariteplatz 1, Berlin, 10117, Germany
    Breast Cancer Res 11:R69. 2009
    ....
  8. pmc GOLPH2 expression in renal cell cancer
    Florian Rudolf Fritzsche
    Institute of Surgical Pathology, Universitatsspital Zurich, Zurich, Switzerland
    BMC Urol 8:15. 2008
    ..GOLPH2 (golgi phosphoprotein 2, GOLM1) has recently been proposed as a biomarker for hepatocellular and prostate cancer. In this study we analysed the expression patterns and the prognostic and diagnostic value of GOLPH2 in RCC...
  9. pmc GOLPH2 expression may serve as diagnostic marker in seminomas
    Florian R Fritzsche
    Institute of Surgical Pathology, Universitäts Spital Zürich, Zurich, Switzerland
    BMC Urol 10:4. 2010
    ..In this study, we aimed to evaluate the expression pattern of GOLPH2 in testicular seminomas, the most common histologic subtype of testicular neoplasm...
  10. pmc An intracellular targeted antibody detects EGFR as an independent prognostic factor in ovarian carcinomas
    Aurelia Noske
    Institute of Pathology, University Hospital Charite Berlin, Germany
    BMC Cancer 11:294. 2011
    ..In ovarian cancer, the reported rate of EGFR expression varies between 4-70% depending on assessment method and data on patient outcome are conflicting...
  11. pmc Down-regulation of the pro-apoptotic XIAP associated factor-1 (XAF1) during progression of clear-cell renal cancer
    Carsten Kempkensteffen
    Institute of Surgical Pathology, Universitatsspital Zurich, 8091 Zurich, Switzerland
    BMC Cancer 9:276. 2009
    ..However, little is yet known about its potential implication in the tumour biology of clear-cell renal cell cancer (ccRCC)...
  12. pmc ADAM9 is highly expressed in renal cell cancer and is associated with tumour progression
    Florian R Fritzsche
    Institute of Surgical Pathology, Universitatsmedizin Berlin, Berlin, Germany
    BMC Cancer 8:179. 2008
    ..We evaluated the expression of ADAM9 on protein and transcript level in a clinico-pathologically characterized renal cell cancer cohort...
  13. pmc Preoperative short-course radiotherapy versus combined radiochemotherapy in locally advanced rectal cancer: a multi-centre prospectively randomised study of the Berlin Cancer Society
    Robert Siegel
    Department of Surgery and Surgical Oncology, Charité Comprehensive Cancer Center, Charite Universitatsmedizin Berlin, Berlin, Germany
    BMC Cancer 9:50. 2009
    ..However, the German Rectal Cancer Study Group recently demonstrated that preoperative radiochemotherapy (RCT) was better than postoperative radiochemotherapy in terms of local control...
  14. pmc High class I HDAC activity and expression are associated with RelA/p65 activation in pancreatic cancer in vitro and in vivo
    Annika Lehmann
    Institute of Pathology, Charite University Hospital, Berlin, Germany
    BMC Cancer 9:395. 2009
    ..The strong association between aberrant HDAC activity and the occurrence of cancer has led to the development of a variety of HDAC inhibitors (HDIs), which emerge as promising new targeted anticancer therapeutics...
  15. pmc Class I histone deacetylases 1, 2 and 3 are highly expressed in renal cell cancer
    Florian R Fritzsche
    Institute of Pathology, Charite Universitatsmedizin, Berlin, Germany
    BMC Cancer 8:381. 2008
    ..The over-expression of these proteins and their known functions in malignant neoplasms has led to the development of HDAC inhibitors (HDI) as new anti-neoplastic drugs. However, little is known about HDAC expression in renal cell cancer...
  16. ncbi request reprint Hormone replacement therapy: pathobiological aspects of hormone-sensitive cancers in women relevant to epidemiological studies on HRT: a mini-review
    M Dietel
    Institut fur Pathologie, Charite, Humboldt Universitat Berlin, Schumannstr 20 21, D 10117 Berlin, Germany
    Hum Reprod 20:2052-60. 2005
    ..The results of previous studies should be interpreted with great caution with regard to tumour biology...
  17. ncbi request reprint The histological diagnosis of endometrial hyperplasia. Is there a need to simplify?
    M Dietel
    Institute of Pathology, Charite, Humboldt Universitat zu Berlin, Germany
    Virchows Arch 439:604-8. 2001
    ..This article summarizes the current discussion on this issue...
  18. ncbi request reprint Personalized medicine and development of targeted therapies: The upcoming challenge for diagnostic molecular pathology. A review
    Manfred Dietel
    Institute of Pathology, Charite, University Hospital Berlin, Humboldt University, Schumannstr 20 21, 10117 Berlin, Germany
    Virchows Arch 448:744-55. 2006
    ..Therefore, a "multiplex approach" combining the different biological levels DNA, RNA, and protein, may be necessary to functionally classify malignant tumors. This appears to become a major challenge for diagnostic pathologists...
  19. ncbi request reprint Comparison of automated silver enhanced in situ hybridisation (SISH) and fluorescence ISH (FISH) for the validation of HER2 gene status in breast carcinoma according to the guidelines of the American Society of Clinical Oncology and the College of America
    M Dietel
    Institute of Pathology, Charite University Medicine Berlin, Berlin, Germany
    Virchows Arch 451:19-25. 2007
    ..Because SISH combines bright field microscopy with molecular analysis and full automation, it appears to be particularly suited for routine application in surgical pathology...
  20. ncbi request reprint Predictive medicine: incipient reality or fata morgana?
    M Dietel
    Institut fur Pathologie, Charite University Medicine, Chariteplatz 1, D 10117 Berlin, Germany
    J Pathol 212:353-5. 2007
    ..The questions, challenges, and possible answers related to this complex issue as well as the prerequisites for the development of more efficient and less toxic cancer therapy are discussed...
  21. doi request reprint Hormone replacement therapy (HRT), breast cancer and tumor pathology
    Manfred Dietel
    Institut fur Pathologie, Charite, Campus Mitte, Humboldt Universitat Berlin, Chariteplatz 1, D 10117 Berlin, Germany
    Maturitas 65:183-9. 2010
    ..The major arguments are: In summary, HRT is hence more likely to be a tumor promoter than a de novo-inducer of breast cancers...
  22. doi request reprint [Molecular pathologic KRAS mutation analysis. A prerequisite of effective antibody treatment for metastasized colorectal cancer]
    M Dietel
    Institut fur Pathologie, Charite Universitatsmedizin Berlin, Campus Mitte, Chariteplatz 1, 10117, Berlin, Deutschland
    Chirurg 79:576-9. 2008
  23. ncbi request reprint [Electronic communication in medicine]
    M Dietel
    Institut fur Pathologie, Medizinische Fakultat, Charité der Humboldt Universität zu Berlin
    Z Arztl Fortbild Qualitatssich 95:596-600. 2001
    ..The review shows the variety of possibilities for medical applications. Technique, routine application, experiences and the legal conditions are presented for telepathology as an example...
  24. ncbi request reprint Serous tumors of low malignant potential of the ovary. 1. Diagnostic pathology
    M Dietel
    Institute of Pathology, Charite Hospital, Humboldt University Berlin, Germany
    Virchows Arch 436:403-12. 2000
    ..The concepts of molecular pathology of SLMP will be discussed in part 2 of this serial paper.)..
  25. doi request reprint Systems pathology--or how to solve the complex problem of predictive pathology
    Manfred Dietel
    Department of Pathology, Charite University Medicine Berlin, Chariteplatz 1, 10117, Berlin, Germany
    Virchows Arch 453:309-12. 2008
    ..Which options are available to untie the Gordian knot? In this contribution, the potential role of systems biology and, as a further development, systems pathology will be discussed...
  26. ncbi request reprint [Post-mortems with organ and tissue retention]
    Manfred Dietel
    Institut fur Pathologie, Charite University Medicine, Chariteplatz 1, D 10117 Berlin, Germany
    Z Evid Fortbild Qual Gesundhwes 102:189-93; discussion 199. 2008
    ..e., of medicine subjecting itself to rigid quality control as the adequate basis of a humane healthcare system. The most reliable and convenient way to achieve this goal will be the ubiquitous establishment of clinical autopsies...
  27. pmc Cytoplasmic overexpression of ALCAM is prognostic of disease progression in breast cancer
    M Burkhardt
    Institute of Pathology, Charite Universitatsmedizin, Berlin, Germany
    J Clin Pathol 59:403-9. 2006
    ..Activated leucocyte cell adhesion molecule (ALCAM, CD166) is a cell surface member of the immunoglobulin superfamily. ALCAM expression has prognostic relevance in prostate and colon cancer...
  28. ncbi request reprint Unfavorable prognostic value of CD24 expression in sections from primary and relapsed ovarian cancer tissue
    P Surowiak
    Institute of Pathology, Charite Campus Mitte, Schumannstr 20 21, Berlin, Germany
    Int J Gynecol Cancer 16:515-21. 2006
    ..002 and P= 0.05, respectively). Summing up, in this study, we have demonstrated a negative prognostic significance of a cytoplasmic membranous expression of CD24 in cases of ovarian cancer...
  29. ncbi request reprint Expression of DNA repair proteins hMSH2, hMSH6, hMLH1, O6-methylguanine-DNA methyltransferase and N-methylpurine-DNA glycosylase in melanoma cells with acquired drug resistance
    H Lage
    Institute of Pathology, Charite Campus Mitte, Humboldt University Berlin, Germany
    Int J Cancer 80:744-50. 1999
    ..Our data indicate that modulation of both MMR components and MGMT expression level may contribute to the drug-resistant phenotype of melanoma cells...
  30. ncbi request reprint Selection and characterization of a high-activity ribozyme directed against the antineoplastic drug resistance-associated ABC transporter BCRP/MXR/ABCG2
    P Kowalski
    Institute of Pathology, Humboldt University Berlin, Germany
    Cancer Gene Ther 8:185-92. 2001
    ..This ribozyme was characterized in a cell-free system with regard to its specific kinetic parameters using large target molecules...
  31. ncbi request reprint Prediction of doxorubicin sensitivity in breast tumors based on gene expression profiles of drug-resistant cell lines correlates with patient survival
    Balazs Gyorffy
    Charite, Institute of Pathology, Humboldt University, Schumannstr 20 21, Berlin D 10117, Germany
    Oncogene 24:7542-51. 2005
    ..Our approach demonstrates the significance of in vitro experiments in the development of new strategies for cancer response prediction...
  32. doi request reprint Topoisomerase IIalpha mRNA and protein expression in ovarian carcinoma: correlation with clinicopathological factors and prognosis
    Areeg Faggad
    Institute of Pathology, Charite University Hospital, Berlin, Germany
    Mod Pathol 22:579-88. 2009
    ..Our results encourage the further evaluation of the prognostic and predictive values of Top IIalpha expression in ovarian carcinoma, which might help to assess the patients' risk profile, and the planning of an individualized therapy...
  33. ncbi request reprint Expression of AGR2 in non small cell lung cancer
    F R Fritzsche
    Institute of Pathology, Charite Universitatsmedizin Berlin, Berlin, Germany
    Histol Histopathol 22:703-8. 2007
    ..Although a prognostic value of AGR2 seems unlikely further studies are warranted to investigate the biological role of AGR2 in NSCLC and its differential expression according to histology...
  34. ncbi request reprint DFNA5 (ICERE-1) contributes to acquired etoposide resistance in melanoma cells
    H Lage
    Institute of Pathology, Charite, Campus Mitte, Humboldt University Berlin, Germany
    FEBS Lett 494:54-9. 2001
    ....
  35. ncbi request reprint Co-expression and prognostic value of gross cystic disease fluid protein 15 and mammaglobin in primary breast cancer
    F R Fritzsche
    Institute of Pathology, Charite Universitatsmedizin Berlin, Germany
    Histol Histopathol 22:1221-30. 2007
    ..The significantly longer disease free survival times for patients with GCDFP-15 positive tumours clearly warrants further study...
  36. pmc Time gated fluorescence spectroscopy in Barrett's oesophagus
    M A E J Ortner
    4th Medical Department, Charite University Hospital, Humboldt University, Berlin, Germany
    Gut 52:28-33. 2003
    ....
  37. ncbi request reprint ABCC2 (MRP2, cMOAT) can be localized in the nuclear membrane of ovarian carcinomas and correlates with resistance to cisplatin and clinical outcome
    Pawel Surowiak
    Charite Campus Mitte, Institute of Pathology, Berlin, Germany
    Clin Cancer Res 12:7149-58. 2006
    ..Here, we show that ABCC2 can be localized in the cytoplasmic membrane as well as in the nuclear membrane of various human tissues including ovarian carcinoma cells...
  38. pmc Multivariate analysis of oestrogen receptor alpha, pS2, metallothionein and CD24 expression in invasive breast cancers
    P Surowiak
    Institute of Pathology, Charite Campus Mitte, Schumannstr 20 21, D 10117 Berlin, Germany
    Br J Cancer 95:339-46. 2006
    ..Examination of the entire panel of the studied proteins permitted to select a group of patients of an exceptionally good prognosis...
  39. doi request reprint Anterior gradient protein 2 (AGR2) is an independent prognostic factor in ovarian high-grade serous carcinoma
    S Darb-Esfahani
    Institute of Pathology, Charite Universitatsmedizin Berlin, Chariteplatz 1, 10117, Berlin, Germany
    Virchows Arch 461:109-16. 2012
    ..Our data strongly support the further evaluation of AGR2 as a therapeutic target and a potential marker for response to platinum-based CTX in this tumor entity...
  40. ncbi request reprint Kinetic characterization of ribozymes directed against the cisplatin resistance-associated ABC transporter cMOAT/MRP2/ABCC2
    V Materna
    Institute of Pathology, Humboldt University Berlin, Germany
    Cancer Gene Ther 8:176-84. 2001
    ..The cleavage reaction was dependent on time and ribozyme:substrate ratio for determining specific kinetic parameters...
  41. ncbi request reprint [NF-kappaB subunit p65/RelA expression in ovarian carcinoma: prognostic impact and link to COX-2 overexpression]
    S Niesporek
    Institut fur Pathologie, Charite Universitatsmedizin Berlin, Campus Mitte
    Verh Dtsch Ges Pathol 91:243-9. 2007
    ....
  42. ncbi request reprint Serous tumors of low malignant potential of the ovary-molecular pathology: part 2
    S Hauptmann
    Institute of Pathology, Charite Hospital, Humboldt University Berlin, Germany
    Virchows Arch 438:539-51. 2001
    ..In questionable cases, the loss of N-cadherin would argue for the presence of a carcinoma whereas the coexpression of p21 and MDM2 is rather characteristic for SLMP tumors...
  43. pmc Allelic loss on chromosome 10q in human lung cancer: association with tumour progression and metastatic phenotype
    S Petersen
    Institute of Pathology, Department of Otorhinolaryngology, , Berlin, Germany
    Br J Cancer 77:270-6. 1998
    ..The data indicate that LOH on chromosome 10q is associated with tumour progression in SCC and SCLC. Thus it may become a useful genetic marker in the assessment of the malignant potential of these tumour types...
  44. ncbi request reprint Impact of BCRP/MXR, MRP1 and MDR1/P-Glycoprotein on thermoresistant variants of atypical and classical multidrug resistant cancer cells
    Ulrike Stein
    Max Delbruck Center for Molecular Medicine, Berlin, Germany
    Int J Cancer 97:751-60. 2002
    ..Within the thermoresistant variants, however, the increase in ABC transporter expression did obviously not influence the MDR phenotype...
  45. ncbi request reprint Expression of aminopeptidase N/CD13 in human ovarian cancers
    P Surowiak
    Institute of Pathology, Charite Campus Mitte, Berlin, Germany
    Int J Gynecol Cancer 16:1783-8. 2006
    ..001). Thus, the data indicate that a potential treatment of ovarian carcinoma with CD13 inhibitors should be performed before chemotherapy or in parallel to first-lapse chemotherapy...
  46. pmc Small-cell lung cancer is characterized by a high incidence of deletions on chromosomes 3p, 4q, 5q, 10q, 13q and 17p
    I Petersen
    Institute of Pathology, , Berlin, Germany
    Br J Cancer 75:79-86. 1997
    ....
  47. doi request reprint [Comparing immunohistochemical diagnosis of cancer of unknown primary with gene expression-based tumor classification]
    L Morawietz
    Institut fur Pathologie, Charite Universitatsmedizin Berlin, Chariteplatz 1, 10117, Berlin
    Pathologe 30:168-72. 2009
    ..In conclusion, we regard detailed IHC workup and complementary GEP advisable for the purposes of targeted therapy, as well as to identify or exclude specific tumors in a CUP situation...
  48. pmc Reversion of multidrug resistance in the P-glycoprotein-positive human pancreatic cell line (EPP85-181RDB) by introduction of a hammerhead ribozyme
    P S Holm
    Institute of Pathology, Kiel, Germany
    Br J Cancer 70:239-43. 1994
    ..3-fold more resistant than the parental cell line...
  49. ncbi request reprint Enhanced expression of human ABC-transporter tap is associated with cellular resistance to mitoxantrone
    H Lage
    Institute of Pathology, Charite, Humboldt University Berlin, Germany
    FEBS Lett 503:179-84. 2001
    ..Taken together, the data suggest that the heterodimeric TAP complex possesses characteristics of a xenobiotic transporter and that the TAP dimer contributes to the atypical MDR phenotype of human cancer cells...
  50. ncbi request reprint Thyroid transcription factor-1 is the superior immunohistochemical marker for pulmonary adenocarcinomas and large cell carcinomas compared to surfactant proteins A and B
    O Kaufmann
    Institute of Pathology, Charite Hospital, Berlin, Germany
    Histopathology 36:8-16. 2000
    ..Antibodies against the thyroid transcription factor-1 (TTF-1) and the surfactant proteins A and B (SPA, SPB) were compared as paraffin-reactive immunohistochemical markers for non-small cell carcinomas of pulmonary origin...
  51. ncbi request reprint Decreased expression of p16 in ovarian cancers represents an unfavourable prognostic factor
    Pawel Surowiak
    Charite Campus Mitte, Institute of Pathology, Berlin, Germany
    Histol Histopathol 23:531-8. 2008
    ..Lowered p16 expression was also typical for chemotherapy-resistant ceases (cases of lower caspase-3 and higher Ki67 at secondary cytoreduction expression)...
  52. ncbi request reprint Evaluation of Mucin-1 protein and mRNA expression as prognostic and predictive markers after neoadjuvant chemotherapy for breast cancer
    B V Sinn
    Department of Pathology, Charite Universitatsmedizin Berlin, Berlin
    Ann Oncol 24:2316-24. 2013
    ..Mucin-1 (MUC1) is a promising antigen for the development of tumor vaccines. We evaluated the frequency of MUC1 expression and its impact on therapy response and survival after neoadjuvant chemotherapy for breast cancer...
  53. doi request reprint [Breast cancer: current recommendations for pathologists on the basis of the S3 guidelines]
    A Lebeau
    Institut fur Pathologie, Universitatsklinikum Hamburg Eppendorf, Martinistrasse 52, Hamburg, Germany
    Pathologe 34:293-302; quiz 303-4. 2013
    ..Its third edition was published in July 2012. In this article an overview of the topics relevant for pathologists that have been modified in the latest edition is provided. ..
  54. ncbi request reprint RNA-based determination of ESR1 and HER2 expression and response to neoadjuvant chemotherapy
    C Denkert
    Institute of Pathology, Charite Universitatsmedizin Berlin, D 10117 Berlin
    Ann Oncol 24:632-9. 2013
    ..In this study, we investigated the clinical validity of RT-PCR-based evaluation of estrogen receptor (ESR1) and HER2 mRNA expression...
  55. ncbi request reprint Pathologic correlation of sonographic echogenic foci in the fetal heart
    C Tennstedt
    Department of Pathology, Charite, Medical Faculty of the Humboldt University, Berlin, Germany
    Prenat Diagn 20:287-92. 2000
    ..Conventional histological methods gave no indication of the cause of the intramyocardial calcifications...
  56. ncbi request reprint Borderline tumors of the ovary and peritoneal implants
    C Denkert
    Institute of Pathology, Charite Hospital, Humboldt University Berlin, Schumannstrasse 20 21, D 10117 Berlin, Germany
    Verh Dtsch Ges Pathol 89:84-91. 2005
    ..The concept of micropapillary serous carcinomas (MPSC) and its implications on the diagnostic work of pathologists will be discussed. The presented data focus on serous tumors since this is by far the most common variant...
  57. pmc Chromosome alterations in breast carcinomas: frequent involvement of DNA losses including chromosomes 4q and 21q
    A Schwendel
    Institute of Pathology, , Humboldt University Berlin, Germany
    Br J Cancer 78:806-11. 1998
    ..We speculate that these changes are associated with tumour progression of invasive ductal breast cancer...
  58. ncbi request reprint Expression of thyroid transcription factor-1 in pulmonary and extrapulmonary small cell carcinomas and other neuroendocrine carcinomas of various primary sites
    O Kaufmann
    Institute of Pathology, Charite University Hospital, Berlin, Germany
    Histopathology 36:415-20. 2000
    ....
  59. ncbi request reprint Fetal autopsy: a review of recent developments
    C Tennstedt
    Department of Pathology, Charité Medical Faculty of the Humboldt University, D 10098 Berlin, Germany
    Eur J Obstet Gynecol Reprod Biol 99:66-71. 2001
    ..To analyze recent changes in fetal autopsy in response to developments in prenatal medicine...
  60. ncbi request reprint Effect of the breast-cancer resistance protein on atypical multidrug resistance
    H Lage
    Institute of Pathology, University Hospital Charite, Humboldt University Berlin, Germany
    Lancet Oncol 1:169-75. 2000
    ..Although the role of BCRP in drug resistance of clinical cancers is still unclear, preliminary data obtained by mRNA and protein expression analyses support the assumption that it has a role in clinical multidrug resistance...
  61. ncbi request reprint Value of p63 and cytokeratin 5/6 as immunohistochemical markers for the differential diagnosis of poorly differentiated and undifferentiated carcinomas
    O Kaufmann
    Institute of Pathology, , Berlin, Germany
    Am J Clin Pathol 116:823-30. 2001
    ..All malignant mesotheliomas were negative for p63. Our data suggest that positive immunostaining for both p63 and CK5/6 in poorly differentiated metastatic carcinomas is highly predictive of a primary tumor of squamous epithelial origin...
  62. doi request reprint Prognostic significance of Dicer expression in ovarian cancer-link to global microRNA changes and oestrogen receptor expression
    Areeg Faggad
    Institute of Pathology, Charite University Hospital, 10117 Berlin, Germany
    J Pathol 220:382-91. 2010
    ..Knowledge of these molecular pathways may help toward new targeted therapeutic approaches for ovarian cancer...
  63. ncbi request reprint Cytoplasmic CD24 expression in colorectal cancer independently correlates with shortened patient survival
    Wilko Weichert
    Institute of Pathology and Tumor Center, Charite University Hospital, Berlin, Germany
    Clin Cancer Res 11:6574-81. 2005
    ..We aimed to clarify the expression patterns of CD24 in colorectal cancer and to correlate these to clinicopathologic variables including patient survival...
  64. ncbi request reprint CD10 expression in non-small cell lung cancer
    Glen Kristiansen
    Institute of Pathology, Charite University Hospital, Berlin, Germany
    Anal Cell Pathol 24:41-6. 2002
    ..We conclude that a diagnostic use of CD10 immunostaining in NSCLC is unlikely...
  65. ncbi request reprint Prognostic relevance of AGR2 expression in breast cancer
    Florian Rudolf Fritzsche
    Institute of Pathology and Breast Centre, Charite, Universitatsmedizin Berlin, Berlin, Germany
    Clin Cancer Res 12:1728-34. 2006
    ..We aimed to evaluate the expression of the human anterior gradient-2 (AGR2) in breast cancer on RNA and protein level and to correlate it with clinicopathologic data, including patient survival...
  66. ncbi request reprint Overexpression of c-erbB2 protein correlates with disease-stage and chromosomal gain at the c-erbB2 locus in non-small cell lung cancer
    G Kristiansen
    Institute of Pathology, , Schumannstr. 20/21, 10117, Berlin, Germany
    Eur J Cancer 37:1089-95. 2001
    ..We conclude that c-erbB2 is a marker of tumour progression in NSCLC which can be observed on protein level and reflects chromosomal alterations at 17q21...
  67. ncbi request reprint Uterine tumor resembling ovarian sex-cord tumor--a case report and review of the literature
    S Hauptmann
    Institute of Pathology, Charité Hospital Berlin, Germany
    Virchows Arch 439:97-101. 2001
    ..It is thus questionable whether the same prognostic criteria apply for these tumors as for endometrial stromal sarcomas. However, in the so-called mixed UTROSCT, the endometrial stromal sarcoma component determines the outcome...
  68. ncbi request reprint Thermosensitivity of multidrug-resistant human gastric and pancreatic carcinoma cells
    H Lage
    Institute of Pathology, Humboldt University Berlin, Germany
    Int J Hyperthermia 16:291-303. 2000
    ..7-fold (gastric carcinoma, atypical MDR) and 1.4-fold (pancreatic carcinoma, classical MDR) increase of activation enthalpies and a nearby unchanged E(A) in pancreatic carcinoma cells exhibiting an atypical MDR...
  69. pmc Chromosomal alterations in the clonal evolution to the metastatic stage of squamous cell carcinomas of the lung
    S Petersen
    Institute of Pathology, , Berlin, Germany
    Br J Cancer 82:65-73. 2000
    ..Individual profiles and histograms are accessible at our web site http://amba.charite.de/cgh...
  70. pmc ALCAM/CD166 is overexpressed in colorectal carcinoma and correlates with shortened patient survival
    W Weichert
    Institute of Pathology, Charite University Hospital, D 10117 Berlin, Germany
    J Clin Pathol 57:1160-4. 2004
    ..Activated leucocyte cell adhesion molecule (ALCAM) has been implicated in tumorigenesis and tumour progression of malignant melanoma and prostate cancer...
  71. pmc Histone deacetylases 1, 2 and 3 are highly expressed in prostate cancer and HDAC2 expression is associated with shorter PSA relapse time after radical prostatectomy
    W Weichert
    Institute of Pathology, Charite Universitatsmedizin, Berlin, Germany
    Br J Cancer 98:604-10. 2008
    ..Also, the highly significant prognostic value of HDAC2 clearly deserves further study...
  72. ncbi request reprint Expression of a glypican-related 62-kDa antigen is decreased in hepatocellular carcinoma in correspondence to the grade of tumor differentiation
    H Lage
    Institute of Pathology, Charite Campus Mitte, Humboldt University Berlin, Germany
    Virchows Arch 438:567-73. 2001
    ..1 for normal hepatocytes, was significantly reduced to 1.2 for G1, 1.0 for G2, and 0.2 for G3 HCCs. These data suggest that neoplastic transformation is associated with a reduced p62 content...
  73. pmc Expression of lysophosphatidic acid acyltransferase beta (LPAAT-beta) in ovarian carcinoma: correlation with tumour grading and prognosis
    S Niesporek
    Institute of Pathology, Charite University Hospital, Campus Mitte, Schumannstr 20 21, 10117 Berlin, Germany
    Br J Cancer 92:1729-36. 2005
    ..In addition, LPAAT-beta expression is a predictor of a worse prognosis in patients younger than 60 years. Further studies are needed to investigate if LPAAT-beta may serve as a therapeutic target for certain subgroups of patients...
  74. ncbi request reprint Identification of differentially expressed genes in human melanoma cells with acquired resistance to various antineoplastic drugs
    C Grottke
    Institute of Pathology, Charite, Campus Mitte, Humboldt University Berlin, Berlin, Germany
    Int J Cancer 88:535-46. 2000
    ..Further characterization of these genes may yield inside into the biology and development of drug resistance in malignant melanoma...
  75. ncbi request reprint ADAM9 expression is a significant and independent prognostic marker of PSA relapse in prostate cancer
    Florian R Fritzsche
    Institute of Pathology, Charite Universitatsmedizin Berlin, Berlin, Germany
    Eur Urol 54:1097-106. 2008
    ....
  76. ncbi request reprint Analysis of gene expression profiles in melanoma cells with acquired resistance against antineoplastic drugs
    Balazs Gyorffy
    Institute of Pathology, Charite Campus Mitte, Universitatsmedizin Berlin, Berlin, Germany
    Melanoma Res 16:147-55. 2006
    ..Our study provides new data that may be used to obtain further insight into the resistance characteristics of malignant melanoma...
  77. ncbi request reprint Nuclear metallothionein expression correlates with cisplatin resistance of ovarian cancer cells and poor clinical outcome
    Paweł Surowiak
    Institute of Pathology, Charite Campus Mitte, Chariteplatz 1, 10117, Berlin, Germany
    Virchows Arch 450:279-85. 2007
    ..No relationship could be demonstrated between cytoplasmic expression of MT and clinical variables. Nuclear MT expression is induced by cisplatin and seems to protect DNA in the cells from toxic effects of the drug...
  78. ncbi request reprint Increased CD59 protein expression predicts a PSA relapse in patients after radical prostatectomy
    Chuanliang Xu
    Department of Urology, Charite University Hospital, Berlin, Germany
    Prostate 62:224-32. 2005
    ..Since a comprehensive investigation of CD59 expression in prostate cancer has not been conducted yet, we aimed to determine the significance of CD59 expression in prostate cancer...
  79. ncbi request reprint [Study of efficiancy of teleconsultation: the Telepathology Consultation Service of the Professional Assoziation of German Pathologists for the screening program of breast carcinoma]
    T Schrader
    Institut fur Pathologie, Charite
    Verh Dtsch Ges Pathol 89:211-8. 2005
    ..A new Telepathology Consultation Service was developed based on the experiences of the Telepathology Consultation Center of the UICC to speed up the second opinion process...
  80. ncbi request reprint Immunohistochemical detection of CD5 with monoclonal antibody 4C7 on paraffin sections
    O Kaufmann
    Institute of Pathology, Charite University Hospital, Berlin, Germany
    Am J Clin Pathol 108:669-73. 1997
    ..We conclude that MAb 4C7 against CD5 is a useful paraffin-reactive marker, especially to correctly identify MCLs on paraffin sections...
  81. pmc High expression of RelA/p65 is associated with activation of nuclear factor-kappaB-dependent signaling in pancreatic cancer and marks a patient population with poor prognosis
    W Weichert
    Institute of Pathology, Charite University Hospital, Berlin, Germany
    Br J Cancer 97:523-30. 2007
    ..Based on our findings, this subgroup could be identified by applying simple immunohistochemical techniques...
  82. doi request reprint A snapshot of microarray-generated gene expression signatures associated with ovarian carcinoma
    B Gyorffy
    Charite Campus Mitte, Institute of Pathology, Berlin, Germany
    Int J Gynecol Cancer 18:1215-33. 2008
    ....
  83. ncbi request reprint Microsatellite alterations in serum DNA of patients with colorectal cancer
    K Kölble
    Tumorgenetik, Max Delbruck Centrum fur Molekulare Medizin, Klinik fur Chirurgie und Chirurgische Onkologie, Robert Rossle Klinik, Berlin, Germany
    Lab Invest 79:1145-50. 1999
    ....
  84. ncbi request reprint Maspin expression is characteristic for cisplatin-sensitive ovarian cancer cells and for ovarian cancer cases of longer survival rates
    Pawel Surowiak
    Institute of Pathology, Charite Campus Mitte, Berlin, Germany
    Int J Gynecol Pathol 25:131-9. 2006
    ..Higher nuclear maspin at first-look laparotomies expression was specific for cases of complete response. In the study, the elevated expression of maspin was shown to be typical for cisplatin-sensitive ovarian cancers...
  85. ncbi request reprint Identification of differentially expressed genes in classical and atypical multidrug-resistant gastric carcinoma cells
    Antje Ludwig
    Institute of Pathology, Charite Campus Mitte, Humboldt University Berlin, Schumannstr 20 21, D 10117 Berlin, Germany
    Anticancer Res 22:3213-21. 2002
    ..Moreover, these genes may be potential candidate factors for the diagnostics and/or prognosis of clinical drug resistance...
  86. ncbi request reprint Overexpression of c-erbB-2 protein correlates with chromosomal gain at the c-erbB-2 locus and patient survival in advanced colorectal carcinomas
    Thomas Knösel
    Institute of Pathology, Charite Campus Mitte, Berlin, Germany
    Clin Exp Metastasis 19:401-7. 2002
    ..We conclude that c-erbB-2 is related with tumor progression in CRC which can be observed on protein level and reflects chromosomal gain at the locus at 17q...
  87. doi request reprint Expression of prostatic acid phosphatase (PSAP) in transurethral resection specimens of the prostate is predictive of histopathologic tumor stage in subsequent radical prostatectomies
    Sven Gunia
    Department of Pathology, Helios Clinic Bad Saarow, Charité University Medicine Teaching Hospital, Pieskower Strasse 33, 15526, Bad Saarow, Germany
    Virchows Arch 454:573-9. 2009
    ..Therefore, PSAP might be predictive of tumor stage in IPC and represent a valuable adjunct for clinical decisions in terms of individual therapeutic management...
  88. ncbi request reprint Expression of CD24 in adenocarcinomas of the pancreas correlates with higher tumor grades
    Juliane Jacob
    Institute of Pathology, Charite University Hospital, Berlin, Germany
    Pancreatology 4:454-60. 2004
    ..We aimed to evaluate CD24 protein expression in pancreatic adenocarcinomas and to correlate it to clinicopathological data including patient survival...
  89. pmc Immunoprofiles of 11 biomarkers using tissue microarrays identify prognostic subgroups in colorectal cancer
    Thomas Knösel
    Institute of Pathology, Charite Campus Mitte, Berlin, Germany
    Neoplasia 7:741-7. 2005
    ....
  90. ncbi request reprint Expression of mitogen-activated protein kinase phosphatase-1 (MKP-1) in primary human ovarian carcinoma
    Carsten Denkert
    Institute of Pathology, Charite Hospital, Berlin, Germany
    Int J Cancer 102:507-13. 2002
    ..Further studies are needed to determine whether MKP-1 expression is a clinically useful marker to estimate patient prognosis as well as the response to chemotherapy...
  91. pmc Thymosin beta 15A (TMSB15A) is a predictor of chemotherapy response in triple-negative breast cancer
    S Darb-Esfahani
    Institute of Pathology, Charite Universitatsmedizin Berlin, Chariteplatz 1, 10117 Berlin, Germany
    Br J Cancer 107:1892-900. 2012
    ..Biomarkers predictive of pathological complete response (pCR) to neoadjuvant chemotherapy (NACT) of breast cancer are urgently needed...
  92. ncbi request reprint Genetic imbalances with impact on survival in colorectal cancer patients
    T Knösel
    Institute of Pathology, Charite Campus Mitte, Berlin, Germany
    Histopathology 43:323-31. 2003
    ..Markers that reliably predict survival are needed. These markers should guide the clinical treatment of neoplastic disease...
  93. ncbi request reprint Antigenicity testing by immunohistochemistry after tissue oxidation
    C Blind
    Institute of Pathology, Charite Campus Mitte, Chariteplatz 1, 10117 Berlin
    J Clin Pathol 61:79-83. 2008
    ..Oxidation and drying are presumed mechanisms of antigenicity loss. To prove this, degradation of immunoreactivity was provoked by chemical oxidation, photo-oxidation and artificial drying...
  94. ncbi request reprint Involvement of the c-erbB-2 oncogene product in the EGF-induced cell motility of SK-OV-3 ovarian cancer cells
    K Wiechen
    Institute of Pathology, Universitatsklinikum Charite, Medizinische Fakultät der Humboldt Universität, Berlin, Germany
    Int J Cancer 83:409-14. 1999
    ..The enhancement of tumor-cell motility may be partially responsible for the unfavorable prognosis of ovarian cancer with over-expression of c-erbB-2...
  95. pmc Suppression of the c-erbB-2 gene product decreases transformation abilities but not the proliferation and secretion of proteases of SK-OV-3 ovarian cancer cells
    K Wiechen
    Institute of Pathology, , , Germany
    Br J Cancer 81:790-5. 1999
    ....
  96. pmc Expression of human Kallikrein 14 (KLK14) in breast cancer is associated with higher tumour grades and positive nodal status
    F Fritzsche
    Institute of Pathology, Department of Urology, Charite Universitatsmedizin, Berlin, Germany
    Br J Cancer 94:540-7. 2006
    ....
  97. pmc Polo-like kinase isoform expression is a prognostic factor in ovarian carcinoma
    W Weichert
    Institute of Pathology, Charite Hospital, Humboldt University, Schumannstrasse 20 21, Berlin 10117, Germany
    Br J Cancer 90:815-21. 2004
    ..Furthermore, this study suggests that PLK1 is a novel independent prognostic marker in ovarian carcinomas...
  98. pmc CD24 is an independent prognostic marker of survival in nonsmall cell lung cancer patients
    G Kristiansen
    Institute of Pathology, Charite University Hospital, Berlin, Germany
    Br J Cancer 88:231-6. 2003
    ..We hypothesise that the decreased survival of NSCLC patients with strongly CD24-positive tumours is related to an enhanced propensity of haematogenous metastasis formation, which might be P-Selectin mediated...
  99. ncbi request reprint Systematic identification and molecular characterization of genes differentially expressed in breast and ovarian cancer
    Edgar Dahl
    Institute of Pathology, RWTH Aachen, Germany
    J Pathol 205:21-8. 2005
    ..The majority of these differentially expressed genes have not been described previously in the context of breast and ovarian cancer, and may constitute novel diagnostic markers for these tumour entities...
  100. ncbi request reprint Overexpression of cyclooxygenase-2 correlates with chromosomal gain at the cyclooxygenase-2 locus and decreased patient survival in advanced colorectal carcinomas
    Thomas Knösel
    Institute of Pathology, Charite Campus Mitte, Berlin, Germany
    Dis Colon Rectum 47:70-7. 2004
    ..This study was designed to evaluate the rate of cyclooxygenase-2 overexpression in our tumor collection and to clarify its correlation with the chromosomal status at the cyclooxygenase-2 locus in colorectal cancer...
  101. doi request reprint Expression of CD44s in incidental prostate cancer is more strongly associated with Gleason scores on subsequent radical prostatectomies than conventional prognostic parameters
    Sven Gunia
    Department of Pathology, Helios Clinic Bad Saarow, Charité University Medicine Teaching Hospital, DE 15526 Bad Saarow, Germany
    Pathobiology 76:286-92. 2009
    ..Recently, expression of CD44s (standard isoform), a transmembranous glycoprotein, has been linked to prognostic outcome in prostate cancer, but its prognostic role in IPC has been neglected so far...