Ralf Dechend

Summary

Affiliation: Humboldt University
Country: Germany

Publications

  1. ncbi request reprint Vascular endothelial cell-specific NF-kappaB suppression attenuates hypertension-induced renal damage
    Norbert Henke
    Medical Faculty of the Charite, Franz Volhard Clinic, HELIOS Klinikum Berlin, Germany
    Circ Res 101:268-76. 2007
  2. ncbi request reprint Activating auto-antibodies against the AT1 receptor in preeclampsia
    Ralf Dechend
    Medical Faculty of the Charite, Franz Volhard Clinic HELIOS Klinikum Berlin, Germany
    Autoimmun Rev 4:61-5. 2005
  3. pmc Angiotensin II induced inflammation in the kidney and in the heart of double transgenic rats
    Juergen Theuer
    Franz Volhard Clinic, Charite and Max Delbrück Center for Molecular Medicine, Berlin, Humboldt University of Berlin, Germany
    BMC Cardiovasc Disord 2:3. 2002
  4. ncbi request reprint Hydroxymethylglutaryl coenzyme A reductase inhibition reduces Chlamydia pneumoniae-induced cell interaction and activation
    Ralf Dechend
    Franz Volhard Clinic at the Max Delbrück Center for Molecular Medicine, HELIOS Klinikum Berlin, Wiltberg Strasse 50, 13125 Berlin, Germany
    Circulation 108:261-5. 2003
  5. ncbi request reprint Dietary n-3 polyunsaturated fatty acids and direct renin inhibition improve electrical remodeling in a model of high human renin hypertension
    Robert Fischer
    Medical Faculty of the Charite, Experimental and Clinical Research Center, Franz Volhard Clinic and HELIOS Klinikum Berlin Buch, Berlin, Germany
    Hypertension 51:540-6. 2008
  6. ncbi request reprint Angiotensin II-induced sudden arrhythmic death and electrical remodeling
    Robert Fischer
    Medical Faculty of the Charite, Franz Volhard Clinic HELIOS Klinikum, Wiltberg Strasse 50, 13125 Berlin, Germany
    Am J Physiol Heart Circ Physiol 293:H1242-53. 2007
  7. ncbi request reprint Low-dose renin inhibitor and low-dose AT(1)-receptor blocker therapy ameliorate target-organ damage in rats harbouring human renin and angiotensinogen genes
    Ralf Dechend
    Universitary Medicine Berlin, Charite Campus Buch, Franz Volhard Clinic, HELIOS Klinikum Berlin, Germany
    J Renin Angiotensin Aldosterone Syst 8:81-4. 2007
  8. ncbi request reprint Complement activation in angiotensin II-induced organ damage
    Erdenechimeg Shagdarsuren
    Medical Faculty of the Charite, Franz Volhard Clinic, and HELIOS Klinikum Berlin, Germany
    Circ Res 97:716-24. 2005
  9. ncbi request reprint Aldosterone synthase inhibitor ameliorates angiotensin II-induced organ damage
    Anette Fiebeler
    Medical Faculty of the Charite, HELIOS Klinikum Berlin, Franz Volhard Clinic, Berlin, Germany
    Circulation 111:3087-94. 2005
  10. pmc Alpha1A-adrenergic receptor-directed autoimmunity induces left ventricular damage and diastolic dysfunction in rats
    Katrin Wenzel
    Medical Faculty of the Charite, Berlin, Germany
    PLoS ONE 5:e9409. 2010

Detail Information

Publications52

  1. ncbi request reprint Vascular endothelial cell-specific NF-kappaB suppression attenuates hypertension-induced renal damage
    Norbert Henke
    Medical Faculty of the Charite, Franz Volhard Clinic, HELIOS Klinikum Berlin, Germany
    Circ Res 101:268-76. 2007
    ..We conclude that in vivo NF-kappaB suppression in endothelial cells stops a signaling cascade leading to reduced hypertension-induced renal damage despite high blood pressure...
  2. ncbi request reprint Activating auto-antibodies against the AT1 receptor in preeclampsia
    Ralf Dechend
    Medical Faculty of the Charite, Franz Volhard Clinic HELIOS Klinikum Berlin, Germany
    Autoimmun Rev 4:61-5. 2005
    ..The role of AT1-AA in preeclampsia and other severe hypertensive conditions has not yet been proven with certainty. However, we believe the findings are compelling and warrant further study...
  3. pmc Angiotensin II induced inflammation in the kidney and in the heart of double transgenic rats
    Juergen Theuer
    Franz Volhard Clinic, Charite and Max Delbrück Center for Molecular Medicine, Berlin, Humboldt University of Berlin, Germany
    BMC Cardiovasc Disord 2:3. 2002
    ..Leukocyte infiltration in the vascular wall accompanies PAI-1, MCP-1, iNOS and Tissue Factor expression. Furthermore we show evidence that Ang II causes the upregulation of NF-kB in our model...
  4. ncbi request reprint Hydroxymethylglutaryl coenzyme A reductase inhibition reduces Chlamydia pneumoniae-induced cell interaction and activation
    Ralf Dechend
    Franz Volhard Clinic at the Max Delbrück Center for Molecular Medicine, HELIOS Klinikum Berlin, Wiltberg Strasse 50, 13125 Berlin, Germany
    Circulation 108:261-5. 2003
    ..Chlamydia pneumoniae stimulates chronic inflammation in vascular cells. Hydroxymethylglutaryl coenzyme A reductase inhibitors (statins) may have an ameliorating effect. We investigated possible mechanisms...
  5. ncbi request reprint Dietary n-3 polyunsaturated fatty acids and direct renin inhibition improve electrical remodeling in a model of high human renin hypertension
    Robert Fischer
    Medical Faculty of the Charite, Experimental and Clinical Research Center, Franz Volhard Clinic and HELIOS Klinikum Berlin Buch, Berlin, Germany
    Hypertension 51:540-6. 2008
    ..Thus, n-3 PUFAs and aliskiren improved electrical remodeling, arrhythmia induction, and connexin 43 expression, despite a 70-mm Hg difference in blood pressure and the development of cardiac hypertrophy...
  6. ncbi request reprint Angiotensin II-induced sudden arrhythmic death and electrical remodeling
    Robert Fischer
    Medical Faculty of the Charite, Franz Volhard Clinic HELIOS Klinikum, Wiltberg Strasse 50, 13125 Berlin, Germany
    Am J Physiol Heart Circ Physiol 293:H1242-53. 2007
    ..Untreated dTGR show electrical remodeling and probably die from VT. Los treatment reduces myocardial remodeling and predisposition to arrhythmias. ANG II target organ damage induces VT...
  7. ncbi request reprint Low-dose renin inhibitor and low-dose AT(1)-receptor blocker therapy ameliorate target-organ damage in rats harbouring human renin and angiotensinogen genes
    Ralf Dechend
    Universitary Medicine Berlin, Charite Campus Buch, Franz Volhard Clinic, HELIOS Klinikum Berlin, Germany
    J Renin Angiotensin Aldosterone Syst 8:81-4. 2007
    ..Direct renin inhibition is equally efficacious in this regard. Our study does not fully answer the question of BP-lowering versus RAS inhibition. This question is important and was at least partially addressed with our low-dose model...
  8. ncbi request reprint Complement activation in angiotensin II-induced organ damage
    Erdenechimeg Shagdarsuren
    Medical Faculty of the Charite, Franz Volhard Clinic, and HELIOS Klinikum Berlin, Germany
    Circ Res 97:716-24. 2005
    ..VSMC from dTGR are more sensitive for C3 activation. Our data show that, in this Ang II-induced model, complement activation is a major participant and suggest that TNF-alpha and CRP may play a role in its induction...
  9. ncbi request reprint Aldosterone synthase inhibitor ameliorates angiotensin II-induced organ damage
    Anette Fiebeler
    Medical Faculty of the Charite, HELIOS Klinikum Berlin, Franz Volhard Clinic, Berlin, Germany
    Circulation 111:3087-94. 2005
    ..We tested the hypothesis that reducing aldosterone by inhibiting CYP11B2 or by adrenalectomy (ADX) may ameliorate organ damage. Furthermore, we investigated how much local cardiac aldosterone originates from the adrenal gland...
  10. pmc Alpha1A-adrenergic receptor-directed autoimmunity induces left ventricular damage and diastolic dysfunction in rats
    Katrin Wenzel
    Medical Faculty of the Charite, Berlin, Germany
    PLoS ONE 5:e9409. 2010
    ..Agonistic autoantibodies to the alpha(1)-adrenergic receptor occur in nearly half of patients with refractory hypertension; however, their relevance is uncertain...
  11. doi request reprint Effects of circulating and local uteroplacental angiotensin II in rat pregnancy
    Lydia Hering
    HELIOS Klinikum, Schwanebecker Chaussee 50, 13125 Berlin, Germany
    Hypertension 56:311-8. 2010
    ..Conceivably, upregulation of tissue Ang II in the maternal part of the placenta represents an important growth factor for trophoblast invasion and migration...
  12. ncbi request reprint Inducible NOS inhibition, eicosapentaenoic acid supplementation, and angiotensin II-induced renal damage
    Jurgen Theuer
    Medical Faculty of the Charite, Franz Volhard Clinic HELIOS Klinikum Berlin, Berlin, Germany
    Kidney Int 67:248-58. 2005
    ....
  13. ncbi request reprint p38 mitogen-activated protein kinase inhibition ameliorates angiotensin II-induced target organ damage
    Joon Keun Park
    Medical Faculty of the Charite, Franz Volhard Clinic, HELIOS Klinikum, Berlin, Germany
    Hypertension 49:481-9. 2007
    ..In conclusion, BIRB796 improved survival, target organ damage, and arrhythmogenic potential in angiotensin II-induced target organ damage...
  14. ncbi request reprint Aliskiren, a human renin inhibitor, ameliorates cardiac and renal damage in double-transgenic rats
    Bernhard Pilz
    HELIOS Klinikum Berlin, Franz Volhard Clinic, Medical Faculty of the Charite, Humboldt University of Berlin, Germany
    Hypertension 46:569-76. 2005
    ..We conclude that in dTGR, equieffective antihypertensive doses of Val or aliskiren attenuated end-organ damage. Thus, renin inhibition compares favorably to angiotensin receptor blockade in reversing organ damage in dTGR...
  15. doi request reprint Prorenin and renin-induced extracellular signal-regulated kinase 1/2 activation in monocytes is not blocked by aliskiren or the handle-region peptide
    Sandra Feldt
    Medical Faculty of the Charite, Experimental and Clinical Research Center, Franz Volhard Clinic and HELIOS Klinikum, Berlin Buch, Germany
    Hypertension 51:682-8. 2008
    ..Aliskiren has no (P)RR blocking effect and did not inhibit ERK 1/2 phosphorylation or kinase activity. Finally, we found no evidence that HRP affects renin or prorenin binding and signaling...
  16. ncbi request reprint Agonistic antibodies directed at the angiotensin II, AT1 receptor in preeclampsia
    Ralf Dechend
    Medical Faculty of the Charite, Franz Volhard Clinic HELIOS Klinikum Berlin, Berlin, Germany
    J Soc Gynecol Investig 13:79-86. 2006
    ..The role of AT1-AA in preeclampsia and other severe hypertensive conditions has not yet been proved with certainty. However, we believe the findings are compelling and warrant further study...
  17. ncbi request reprint Agonistic autoantibodies to the AT1 receptor in a transgenic rat model of preeclampsia
    Ralf Dechend
    Medical Faculty of the Charite, Franz Volhard Clinic and Department of Pathology, HELIOS Klinikum Berlin, Germany
    Hypertension 45:742-6. 2005
    ..Finally, we observed an atherosis-like lesion in the spiral arteries of the placental bed, which we called placental-bed arteriolosclerosis. Our model may be relevant to preeclampsia in humans...
  18. ncbi request reprint AT1 receptor agonistic antibodies from preeclamptic patients stimulate NADPH oxidase
    Ralf Dechend
    HELIOS Klinikum Berlin, Franz Volhard Clinic and the Max Delbrück Center for Molecular Medicine, Humboldt University of Berlin, Germany
    Circulation 107:1632-9. 2003
    ..To elucidate their role further, we studied the effects of AT1-AA on reactive oxygen species (ROS), NADPH oxidase expression, and nuclear factor-kappaB (NF-kappaB) activation...
  19. doi request reprint Novel role for inhibitor of differentiation 2 in the genesis of angiotensin II-induced hypertension
    Petra Gratze
    Medical Faculty of the Charite, Experimental and Clinical Research Center, Franz Volhard Clinic, Berlin, Germany
    Circulation 117:2645-56. 2008
    ..We tested the hypothesis that an alteration in the number and quality of circulating blood cells caused by Id2 deletion would ameliorate Ang II-induced target-organ damage...
  20. pmc The putative (pro)renin receptor blocker HRP fails to prevent (pro)renin signaling
    Sandra Feldt
    Experimental and Clinical Research Center, Max Delbruck Center, Lindenberger Weg 80, 13125 Berlin, Germany
    J Am Soc Nephrol 19:743-8. 2008
    ..In addition, the in vitro data do not support the use of the HRP to block AngII-independent prorenin- or renin-mediated effects...
  21. doi request reprint Prevalence of agonistic autoantibodies against the angiotensin II type 1 receptor and soluble fms-like tyrosine kinase 1 in a gestational age-matched case study
    Florian Herse
    Medical Faculty of the Charite, Franz Volhard Clinic, HELIOS Klinikum Berlin Buch and Experimental and Clinical Research Center, Berlin, Germany
    Hypertension 53:393-8. 2009
    ..AT1-AA may represent a better marker for late disease, whereas sFlt1 is a better marker for early onset disease...
  22. pmc Arachidonic acid-metabolizing cytochrome P450 enzymes are targets of {omega}-3 fatty acids
    Cosima Arnold
    Max Delbrueck Center for Molecular Medicine, 13125 Berlin, Germany
    J Biol Chem 285:32720-33. 2010
    ..These results demonstrate that CYP enzymes efficiently convert EPA and DHA to novel epoxy and hydroxy metabolites that could mediate some of the beneficial cardiovascular effects of dietary ω-3 fatty acids...
  23. pmc Potential relevance of alpha(1)-adrenergic receptor autoantibodies in refractory hypertension
    Katrin Wenzel
    Medical Faculty of the Charite, Franz Volhard Clinic and HELIOS Klinikum Berlin, Experimental and Clinical Research Center, Berlin, Germany
    PLoS ONE 3:e3742. 2008
    ..We implied earlier that alpha(1)-AAB might have a mechanistic role and could represent a therapeutic target...
  24. ncbi request reprint Dysregulation of the circulating and tissue-based renin-angiotensin system in preeclampsia
    Florian Herse
    Medical Faculty of the Charite, Franz Volhard Clinic, HELIOS Klinikum, Berlin, Germany
    Hypertension 49:604-11. 2007
    ..We also showed that AT1 autoantibodies cross the ureteroplacental barrier. These components could participate in the pathophysiology of preeclampsia...
  25. ncbi request reprint Aldosterone potentiates angiotensin II-induced signaling in vascular smooth muscle cells
    Istvan Mazak
    Medical Faculty of the Charite, Franz Volhard Clinic, Helios Klinikum Berlin and Max Delbrück Center for Molecular Medicine, Berlin, Germany
    Circulation 109:2792-800. 2004
    ..How Ang II and aldosterone (Ald) might interact is ill defined...
  26. ncbi request reprint Endothelin-converting enzyme inhibition ameliorates angiotensin II-induced cardiac damage
    Dominik N Muller
    HELIOS Klinikum Berlin, Franz Volhard Clinic and Medical Faculty of the Charité, Humboldt University of Berlin, Germany
    Hypertension 40:840-6. 2002
    ..In contrast, the ECE inhibitor treatment showed no renoprotective effect. These data are the first to show that ECE inhibition reduces angiotensin II-induced cardiac damage...
  27. ncbi request reprint AT1 receptor agonistic antibodies, hypertension, and preeclampsia
    Ralf Dechend
    Medical Faculty of the Charite, Franz Volhard Clinic HELIOS Klinikum Berlin, Berlin, Germany
    Semin Nephrol 24:571-9. 2004
    ..The role of AT1-AA in preeclampsia and other severe hypertensive conditions has not yet been proven with certainty. However, we believe the findings are compelling and warrant further study...
  28. doi request reprint AT1-receptor autoantibodies and uteroplacental RAS in pregnancy and pre-eclampsia
    Florian Herse
    Medical Faculty of the Charite, Franz Volhard Clinic, Helios Clinic, Berlin, Germany
    J Mol Med (Berl) 86:697-703. 2008
    ..We summarize recent data emphasizing the pathophysiological role for the autoantibodies and the uteroplacental renin-angiotensin system...
  29. pmc Angiotensin II type 1 receptor antibodies and increased angiotensin II sensitivity in pregnant rats
    Katrin Wenzel
    Medical Faculty of the Charite, Berlin, Germany
    Hypertension 58:77-84. 2011
    ..We show that AT(1)-AB induces Ang II sensitivity. Our mechanistic study supports the existence of an "autoimmune-activating receptor" that could contribute to Ang II sensitivity and possible to preeclampsia...
  30. doi request reprint Amyloid-β peptides activate α1-adrenergic cardiovascular receptors
    Nadine Haase
    Experimental and Clinical Research Center, Lindenberger Weg 80, 13125 Berlin, Germany
    Hypertension 62:966-72. 2013
    ..Our data are relevant to the association between Alzheimer disease and hypertension. They may explain impairment of vascular responses by Aβ and could have therapeutic implications. ..
  31. ncbi request reprint Cardiac gene expression profile in rats with terminal heart failure and cachexia
    Maren Wellner
    HELIOS Klinikum Berlin, Franz Volhard Clinic, and Medical Faculty of the Charité, Humboldt University of Berlin, Germany
    Physiol Genomics 20:256-67. 2005
    ..In contrast, LOS-dTGR and SD had similar expression profiles. These data demonstrate that THF-dTGR show an altered expression profile compared with preterminal dTGR...
  32. ncbi request reprint New aspects in the pathophysiology of preeclampsia
    John M Davison
    Franz Volhard Clinic, Wiltberg Strasse 50, 13125 Berlin, Germany
    J Am Soc Nephrol 15:2440-8. 2004
    ..Preeclamptic women also produce novel autoantibodies that may serve to activate angiotensin receptors. These new observations raise the possibility that the treatment of preeclamptic women will soon be improved...
  33. ncbi request reprint Are we getting closer to a Nobel prize for unraveling preeclampsia?
    Ralf Dechend
    Max Delbruck Center for Molecular Medicine, Building 84, Robert Rossle Strasse 10, 13125 Berlin, Germany
    Curr Cardiol Rep 10:440-7. 2008
    ..The prize will go to the affected women and their afflicted children. For the investigators in the area, such a prize would be welcome...
  34. doi request reprint Adipose tissue-derived soluble fms-like tyrosine kinase 1 is an obesity-relevant endogenous paracrine adipokine
    Florian Herse
    Experimental and Clinical Research Center, Max Delbrueck Center for Molecular Medicine, Charite Campus Buch, Lindenbergerweg 80, 13125 Berlin, Germany
    Hypertension 58:37-42. 2011
    ..We suggest that sFlt-1 could act as a paracrine factor inhibiting adipose tissue growth. Local sFlt-1 may regulate angiogenic potential and thereby influence adipose tissue mass...
  35. pmc A peroxisome proliferator-activated receptor-alpha activator induces renal CYP2C23 activity and protects from angiotensin II-induced renal injury
    Dominik N Muller
    HELIOS Klinikum Berlin, Franz Volhard Clinic, and Medical Faculty of the Charité, Humboldt University of Berlin, Berlin
    Am J Pathol 164:521-32. 2004
    ..We propose that CYP-dependent EET/HEET production may serve as an anti-inflammatory control mechanism...
  36. ncbi request reprint When should pregnant women with an elevated blood pressure be treated?
    Volker Homuth
    Franz Volhard Clinic, HELIOS Klinikum Berlin, Medical Faculty of the Charite, Humboldt University of Berlin, Germany
    Nephrol Dial Transplant 18:1456-7. 2003
  37. pmc Cytochrome P450 subfamily 2J polypeptide 2 expression and circulating epoxyeicosatrienoic metabolites in preeclampsia
    Florian Herse
    Experimental and Clinical Research Center, Lindenberger Weg 80, 13125 Berlin, Germany
    Circulation 126:2990-9. 2012
    ..Preeclampsia is a multisystem disorder of pregnancy, originating in the placenta. Cytochrome P450 (CYP)-dependent eicosanoids regulate vascular function, inflammation, and angiogenesis, which are mechanistically important in preeclampsia...
  38. ncbi request reprint Agonistic antibodies directed at cell surface receptors and cardiovascular disease
    Friedrich C Luft
    Experimental and Clinical Research Center, Medical Faculty of the Charite, Max Delbruck Center for Molecular Medicine, HELIOS Klinikum, Berlin, Germany
    J Am Soc Hypertens 2:8-14. 2008
    ..Nevertheless, the signaling phenomena resulting from these antibodies are well established and mechanistic studies are being intensively pursued. The discovery of agonistic antibodies may provide additional therapeutic avenues...
  39. pmc Immunosuppressive treatment protects against angiotensin II-induced renal damage
    Dominik N Muller
    HELIOS Klinikum Berlin, Franz Volhard Clinic and Medical Faculty of the Charité, Humboldt University of Berlin, Germany
    Am J Pathol 161:1679-93. 2002
    ..Ang II induces dendritic migration directly, whereas in vivo TNF-alpha is involved in dendritic cell infiltration and maturation. Thus, Ang II may initiate events leading to innate and acquired immune response...
  40. doi request reprint Heparin strongly induces soluble fms-like tyrosine kinase 1 release in vivo and in vitro--brief report
    Julia Searle
    Department of Cardiology, Campus Virchow Klinikum, Charite Universitatsmedizin Berlin, Germany
    Arterioscler Thromb Vasc Biol 31:2972-4. 2011
    ..Because sFlt1 has a heparin-binding site, we investigated whether or not heparin releases sFlt1 from the extracellular matrix...
  41. ncbi request reprint Angiotensin II type 1-receptor activating antibodies in renal-allograft rejection
    Duska Dragun
    Department of Nephrology, Charite University Hospital, Berlin, Germany
    N Engl J Med 352:558-69. 2005
    ..Antibodies against HLA antigens cause refractory allograft rejection with vasculopathy in some, but not all, patients...
  42. ncbi request reprint Dysfunction of dysferlin-deficient hearts
    Katrin Wenzel
    Department of Cardiology, Franz Volhard Clinic, Helios Clinic and Campus Virchow Clinic, Charite, Berlin, Germany
    J Mol Med (Berl) 85:1203-14. 2007
    ..Our data suggest that disturbances in dysferlin as well as Z-line proteins and transcription factors particularly under mechanical stress cause cardiomyopathy...
  43. ncbi request reprint Postischemic acute renal failure is reduced by short-term statin treatment in a rat model
    Faikah Gueler
    Department of Internal Medicine Nephrology, Hannover Medical School, Hannover, Germany
    J Am Soc Nephrol 13:2288-98. 2002
    ..The chain of events may involve anti-inflammatory effects, with inhibition of mitogen-activated protein kinase activation and the redox-sensitive transcription factors nuclear factor-kappaB and activator protein-1...
  44. doi request reprint Uterine vascular function in a transgenic preeclampsia rat model
    Stefan Verlohren
    Department of Obstetrics, Franz Volhard Clinic, Berlin, Germany
    Hypertension 51:547-53. 2008
    ..Renin-angiotensin system activation-induced preeclampsia is associated with altered placentation, modified resistance index, and endothelial dysfunction. A disturbed prostacyclin:thromboxane ratio could be an important mediator...
  45. doi request reprint Trophoblasts reduce the vascular smooth muscle cell proatherogenic response
    Lydia Hering
    Experimental and Clinical Research Center, Max Delbruck Center for Molecular Medicine, Berlin, Germany
    Hypertension 51:554-9. 2008
    ..The findings also implicate C3 in the placental vasculopathy observed in preeclampsia...
  46. ncbi request reprint Nf-kappab and AP-1 activation is associated with late lumen loss after porcine coronary angioplasty and antiproliferative beta-irradiation
    Carolin Deiner
    Institute of Veterinary Physiology, Faculty of Veterinary Medicine, FU Berlin, Berlin, Germany
    Cardiovasc Res 75:195-204. 2007
    ..We hypothesized that the transcription factors nuclear factor-{kappa}B (NF-kappaB) and activator protein-1 (AP-1) are involved in these processes. We addressed the role of these mediators in a porcine model of coronary restenosis...
  47. ncbi request reprint Lipoic acid supplementation prevents angiotensin II-induced renal injury
    Eero Mervaala
    Institute of Biomedicine, Pharmacology, Biomedicum Helsinki, University of Helsinki, Finland
    Kidney Int 64:501-8. 2003
    ..We tested whether lipoic acid, an endogenous antioxidant, protects against the Ang II-induced inflammatory response and end-organ damage...
  48. doi request reprint Aliskiren--mode of action and preclinical data
    Dominik N Muller
    Experimental and Clinical Research Center and Max Delbrück Center for Molecular Medicine, Berlin Buch, Robert Rossle Strasse 10, Berlin, Germany
    J Mol Med (Berl) 86:659-62. 2008
    ..Aliskiren is the first of a novel antihypertensive drug class. The preclinical data is very promising. Nevertheless, for the evaluation of its potency in humans, we have to wait for more clinical data...
  49. ncbi request reprint Oxidative stress and preeclampsia: rationale for antioxidant clinical trials
    Maarten T M Raijmakers
    Maternal and Fetal Research Unit, Division of Reproductive Health, Endocrinology, and Development, King s College Hospital, St Thomas Hospital, London, UK
    Hypertension 44:374-80. 2004
    ..A combination test involving several relevant biomarkers is likely to provide the best predictive potential...
  50. ncbi request reprint A gene expression analysis in rat kidney following high and low salt intake
    Peter Barta
    Max Delbruck Center for Molecular Medicine, Humboldt University of Berlin, Berlin, Germany
    J Hypertens 20:1115-20. 2002
    ..The effects of salt intake on renal regulation have been investigated for decades. To find new pathways and to demonstrate the utility of oligonucleotide expression arrays, we studied whole kidneys...
  51. ncbi request reprint Statins and angiotensin II-induced vascular injury
    Ralf Dechend
    Nephrol Dial Transplant 17:349-53. 2002
  52. ncbi request reprint Agonistic angiotensin II type 1 receptor autoantibodies in postpartum women with a history of preeclampsia
    Carl A Hubel
    Magee Womens Research Institute and Department of Obstetrics and Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, PA, USA
    Hypertension 49:612-7. 2007
    ..The impact of AT1-AA after preeclampsia, especially in the context of cardiovascular risk, remains to be determined...