B Dahlmann

Summary

Affiliation: Humboldt University
Country: Germany

Publications

  1. ncbi request reprint Different proteasome subtypes in a single tissue exhibit different enzymatic properties
    B Dahlmann
    Department of Clinical Biochemistry, Deutsches Diabetes Forschungsinstitut, Dusseldorf, Germany
    J Mol Biol 303:643-53. 2000
  2. ncbi request reprint Subtypes of 20S proteasomes from skeletal muscle
    B Dahlmann
    Institut für Biochemie Charité, Humboldt Universitat Berlin, Monbijoustr 2, 10117, Berlin, Germany
    Biochimie 83:295-9. 2001
  3. pmc Role of proteasomes in disease
    Burkhardt Dahlmann
    Institut fur Biochemie, Charite Universitatsmedizin Berlin, Monbijoustr, 2, 10117 Berlin, Germany
    BMC Biochem 8:S3. 2007
  4. ncbi request reprint Proteasomes
    Burkhardt Dahlmann
    Institut fur Biochemie, Charite Universitatsmedizin Berlin, Monbijoustr 2, 10117 Berlin, Germany
    Essays Biochem 41:31-48. 2005
  5. pmc Subunit arrangement in the human 20S proteasome
    F Kopp
    Diabetes Forschungsinstitut, Dusseldorf, Germany
    Proc Natl Acad Sci U S A 94:2939-44. 1997
  6. ncbi request reprint Reconstitution of hybrid proteasomes from purified PA700-20 S complexes and PA28alphabeta activator: ultrastructure and peptidase activities
    F Kopp
    Department of Clinical Biochemistry, Deutsches Diabetes-Forschungsinstitut, , Germany
    J Mol Biol 313:465-71. 2001
  7. ncbi request reprint Identical subunit topographies of human and yeast 20S proteasomes
    B Dahlmann
    Diabetes Forschungsinstitut, Auf m Hennekamp 65, Dusseldorf, D 40225, Germany
    Arch Biochem Biophys 363:296-300. 1999
  8. doi request reprint Polyubiquitin substrates allosterically activate their own degradation by the 26S proteasome
    Dawadschargal Bech-Otschir
    Institut fur Biochemie, Charite Universitatsmedizin Berlin, Monbijoustrasse 2, 10117 Berlin, Germany
    Nat Struct Mol Biol 16:219-25. 2009
  9. doi request reprint The cell-penetrating peptide octa-arginine is a potent inhibitor of proteasome activities
    Alexander Kloss
    Institut für Biochemie CCM, Charite Universitatsmedizin Berlin, Berlin, Germany
    Eur J Pharm Biopharm 72:219-25. 2009
  10. ncbi request reprint Intermediate-type 20 S proteasomes in HeLa cells: "asymmetric" subunit composition, diversity and adaptation
    Nicola Klare
    Institut fur Biochemie, Charite Universitatsmedizin Berlin, Monbijoustrassse 2, 10117 Berlin, Germany
    J Mol Biol 373:1-10. 2007

Collaborators

  • P Kristensen
  • P R Jungblut
  • Peter-M Kloetzel
  • E Feist
  • Silke Meiners
  • Frank Gillardon
  • Alexander Kloss
  • Dawadschargal Bech-Otschir
  • Michael Seeger
  • F Kopp
  • Nicola Klare
  • Katharina Janek
  • Lothar Kuehn
  • Annette Zoeger
  • Frank Schmidt
  • Simone Merforth
  • Antje Ludwig
  • Paul W Sheppard
  • Gesa Consiglieri
  • Hermann Georg Holzhütter
  • Dagmar Siele
  • Cordula Enenkel
  • Marion Schmolke
  • Peter Henklein
  • Annett Helfrich
  • Sebastien Apcher
  • Michael Blau
  • Bernd Thiede
  • Maik Wacker
  • Renate Ackermann
  • Karl Egerer
  • Antonia Osmers
  • L Kuehn
  • K B Hendil
  • A Sobek
  • W Uerkvitz

Detail Information

Publications15

  1. ncbi request reprint Different proteasome subtypes in a single tissue exhibit different enzymatic properties
    B Dahlmann
    Department of Clinical Biochemistry, Deutsches Diabetes Forschungsinstitut, Dusseldorf, Germany
    J Mol Biol 303:643-53. 2000
    ..Therefore, the characteristics of proteasomes purified from tissues or cells represent the average of the different subtype activities which in turn may have different functions in vivo...
  2. ncbi request reprint Subtypes of 20S proteasomes from skeletal muscle
    B Dahlmann
    Institut für Biochemie Charité, Humboldt Universitat Berlin, Monbijoustr 2, 10117, Berlin, Germany
    Biochimie 83:295-9. 2001
    ..Our data show that the properties of 20S proteasomes isolated from a given tissue or cells are always the average of the properties of the whole set of proteasome subtypes...
  3. pmc Role of proteasomes in disease
    Burkhardt Dahlmann
    Institut fur Biochemie, Charite Universitatsmedizin Berlin, Monbijoustr, 2, 10117 Berlin, Germany
    BMC Biochem 8:S3. 2007
    ..Publication history: Republished from Current BioData's Targeted Proteins database (TPdb; http://www.targetedproteinsdb.com)...
  4. ncbi request reprint Proteasomes
    Burkhardt Dahlmann
    Institut fur Biochemie, Charite Universitatsmedizin Berlin, Monbijoustr 2, 10117 Berlin, Germany
    Essays Biochem 41:31-48. 2005
    ..Hybrid proteasomes (19 S regulator-20 S proteasome-PA28) may have a special function during the immune response. The functions of other proteasome accessory complexes, such as PA200 and PI31 are still under investigation...
  5. pmc Subunit arrangement in the human 20S proteasome
    F Kopp
    Diabetes Forschungsinstitut, Dusseldorf, Germany
    Proc Natl Acad Sci U S A 94:2939-44. 1997
    ..The topography shows that for the trypsin-like, the chymotrypsin-like, and the postglutamyl cleaving activities, the pairs of beta type subunits, which are thought to form active sites, are nearest neighbors...
  6. ncbi request reprint Reconstitution of hybrid proteasomes from purified PA700-20 S complexes and PA28alphabeta activator: ultrastructure and peptidase activities
    F Kopp
    Department of Clinical Biochemistry, Deutsches Diabetes-Forschungsinstitut, , Germany
    J Mol Biol 313:465-71. 2001
    ..The multiple peptidase activities of hybrid proteasomes are not different from those of PA28-20 S-PA28 or PA700-20 S-PA700 complexes...
  7. ncbi request reprint Identical subunit topographies of human and yeast 20S proteasomes
    B Dahlmann
    Diabetes Forschungsinstitut, Auf m Hennekamp 65, Dusseldorf, D 40225, Germany
    Arch Biochem Biophys 363:296-300. 1999
    ..Immunoelectron microscopy also showed that the C-terminal extension at the human C2 subunit is flexible but takes up a well-defined position in the proteasome...
  8. doi request reprint Polyubiquitin substrates allosterically activate their own degradation by the 26S proteasome
    Dawadschargal Bech-Otschir
    Institut fur Biochemie, Charite Universitatsmedizin Berlin, Monbijoustrasse 2, 10117 Berlin, Germany
    Nat Struct Mol Biol 16:219-25. 2009
    ..In consequence, polyUb substrates will allosterically stimulate their own degradation...
  9. doi request reprint The cell-penetrating peptide octa-arginine is a potent inhibitor of proteasome activities
    Alexander Kloss
    Institut für Biochemie CCM, Charite Universitatsmedizin Berlin, Berlin, Germany
    Eur J Pharm Biopharm 72:219-25. 2009
    ....
  10. ncbi request reprint Intermediate-type 20 S proteasomes in HeLa cells: "asymmetric" subunit composition, diversity and adaptation
    Nicola Klare
    Institut fur Biochemie, Charite Universitatsmedizin Berlin, Monbijoustrassse 2, 10117 Berlin, Germany
    J Mol Biol 373:1-10. 2007
    ....
  11. ncbi request reprint Circulating proteasomes are functional and have a subtype pattern distinct from 20S proteasomes in major blood cells
    Annette Zoeger
    Institut fur Biochemie, Charite Universitatsmedizin Berlin, Berlin, Germany
    Clin Chem 52:2079-86. 2006
    ..To investigate the origin of circulating proteasomes, we compared some of their features with those of proteasomes isolated from major blood cells...
  12. ncbi request reprint Comprehensive quantitative proteome analysis of 20S proteasome subtypes from rat liver by isotope coded affinity tag and 2-D gel-based approaches
    Frank Schmidt
    Max Planck Institute for Infection Biology, Core Facility Protein Analysis, Berlin, Germany
    Proteomics 6:4622-32. 2006
    ..However, ICAT in conjunction with LC/MALDI-MS was the most accurate method for quantification. The experimental data of this investigation are accessible via http://www.mpiib-berlin.mpg.de/2D-PAGE/...
  13. ncbi request reprint Alteration of 20S proteasome-subtypes and proteasome activator PA28 in skeletal muscle of rat after induction of diabetes mellitus
    Simone Merforth
    Department of Clinical Biochemistry, Deutsches Diabetes Forschungsinstitut, Auf m Hennekamp 65, 40225, Dusseldorf, Germany
    Int J Biochem Cell Biol 35:740-8. 2003
    ..Since this process goes along with de novo biogenesis of 20S proteasomes, it most likely explains the phenomenon of elevated mRNA concentrations of proteasome subunits after induction of diabetes mellitus...
  14. doi request reprint Multiple cardiac proteasome subtypes differ in their susceptibility to proteasome inhibitors
    Alexander Kloss
    Institut für Biochemie CCM, Charite Universitatsmedizin Berlin, Monbijoustr 2, Berlin 10117, Germany
    Cardiovasc Res 85:367-75. 2010
    ..We have resolved the cardiac proteasome into its subtypes and have addressed the key question of how proteasome inhibitors affect single cardiac proteasomal subtypes...
  15. ncbi request reprint The 20S proteasome isolated from Alzheimer's disease brain shows post-translational modifications but unchanged proteolytic activity
    Frank Gillardon
    Boehringer Ingelheim Pharma GmbH and Co, KG, CNS Research, Biberach an der Riss, Germany
    J Neurochem 101:1483-90. 2007
    ..Post-translational modifications of non-catalytic subunits in situ may contribute to the trend towards enhanced hydrolytic activity of the isolated 20S proteasome after removal of the endogenous inhibitors...