F Christoph

Summary

Affiliation: Humboldt University
Country: Germany

Publications

  1. ncbi request reprint Acute scrotum due to arterial bleeding mimicking non-seminomatous germ cell tumor
    F Christoph
    Department of Urology, Charite Universitatsmedizin Berlin Campus Benjamin Franklin, Germany
    Asian J Androl 6:379-81. 2004
  2. ncbi request reprint Regularly methylated novel pro-apoptotic genes associated with recurrence in transitional cell carcinoma of the bladder
    Frank Christoph
    Department of Urology, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany
    Int J Cancer 119:1396-402. 2006
  3. ncbi request reprint Frequent epigenetic inactivation of p53 target genes in seminomatous and nonseminomatous germ cell tumors
    F Christoph
    Department of Urology, Charite, Universitatsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, Germany
    Cancer Lett 247:137-42. 2007
  4. ncbi request reprint Urinary cytokeratin 20 mRNA expression has the potential to predict recurrence in superficial transitional cell carcinoma of the bladder
    Frank Christoph
    Department of Urology, Universitatsmedizin Berlin, Charite Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, Germany
    Cancer Lett 245:121-6. 2007
  5. ncbi request reprint New guidelines for clinical stage I testicular seminoma?
    F Christoph
    Department of Urology, Charite, Universitatsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany
    Oncology 69:455-62. 2005
  6. ncbi request reprint mRNA expression profiles of methylated APAF-1 and DAPK-1 tumor suppressor genes uncover clear cell renal cell carcinomas with aggressive phenotype
    F Christoph
    Department of Urology, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany
    J Urol 178:2655-9. 2007
  7. ncbi request reprint How septic is urosepsis? Clinical course of infected hydronephrosis and therapeutic strategies
    F Christoph
    Department of Urology, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany
    World J Urol 23:243-7. 2005
  8. ncbi request reprint Promoter hypermethylation profile of kidney cancer with new proapoptotic p53 target genes and clinical implications
    Frank Christoph
    Department of Urology, Charite, Universitatsmedizin Berlin, and Department of Urology, Klinikum Fulda gAG, Fulda, Germany
    Clin Cancer Res 12:5040-6. 2006
  9. pmc Methylation of tumour suppressor genes APAF-1 and DAPK-1 and in vitro effects of demethylating agents in bladder and kidney cancer
    F Christoph
    Department of Urology, Charite Campus Benjamin Franklin, Universitatsmedizin Berlin, Hindenburgdamm 30, Berlin 12200, and Institute of Pathoogy, University Hospital Hamburg Eppendorf, Germany
    Br J Cancer 95:1701-7. 2006
  10. doi request reprint Comparative promoter methylation analysis of p53 target genes in urogenital cancers
    Frank Christoph
    Department of Urology, Charite, Universitatsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany
    Urol Int 80:398-404. 2008

Detail Information

Publications45

  1. ncbi request reprint Acute scrotum due to arterial bleeding mimicking non-seminomatous germ cell tumor
    F Christoph
    Department of Urology, Charite Universitatsmedizin Berlin Campus Benjamin Franklin, Germany
    Asian J Androl 6:379-81. 2004
    ..Surgical exploration of the right testis by inguinal approach was performed revealing subcapsular arterial bleeding due to a small nonseminomatous germ cell tumor non-palpable on clinical examination...
  2. ncbi request reprint Regularly methylated novel pro-apoptotic genes associated with recurrence in transitional cell carcinoma of the bladder
    Frank Christoph
    Department of Urology, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany
    Int J Cancer 119:1396-402. 2006
    ..The extent of promoter methylation of specific genes offers additional prognostical information and is associated with the outcome in patients with nonmuscleinvasive and muscleinvasive bladder cancer...
  3. ncbi request reprint Frequent epigenetic inactivation of p53 target genes in seminomatous and nonseminomatous germ cell tumors
    F Christoph
    Department of Urology, Charite, Universitatsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, Germany
    Cancer Lett 247:137-42. 2007
    ..Further studies will be necessary to determine whether the methylation level may be used as marker for risk estimation, especially in clinical stage I disease...
  4. ncbi request reprint Urinary cytokeratin 20 mRNA expression has the potential to predict recurrence in superficial transitional cell carcinoma of the bladder
    Frank Christoph
    Department of Urology, Universitatsmedizin Berlin, Charite Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, Germany
    Cancer Lett 245:121-6. 2007
    ..It helps to categorize patients prior to TUR-B, so that the cystoscopy interval during follow-up may be extended in those with low-risk superficial TCC...
  5. ncbi request reprint New guidelines for clinical stage I testicular seminoma?
    F Christoph
    Department of Urology, Charite, Universitatsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany
    Oncology 69:455-62. 2005
    ....
  6. ncbi request reprint mRNA expression profiles of methylated APAF-1 and DAPK-1 tumor suppressor genes uncover clear cell renal cell carcinomas with aggressive phenotype
    F Christoph
    Department of Urology, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany
    J Urol 178:2655-9. 2007
    ..We determined the relation between promoter methylation and mRNA expression of the p53 target genes APAF-1 and DAPK-1 in 55 consecutive tumor and corresponding normal tissue samples...
  7. ncbi request reprint How septic is urosepsis? Clinical course of infected hydronephrosis and therapeutic strategies
    F Christoph
    Department of Urology, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany
    World J Urol 23:243-7. 2005
    ..Further research is necessary to provide conclusive evidence of the value of other early prognostic markers in patients with infected hydronephrosis...
  8. ncbi request reprint Promoter hypermethylation profile of kidney cancer with new proapoptotic p53 target genes and clinical implications
    Frank Christoph
    Department of Urology, Charite, Universitatsmedizin Berlin, and Department of Urology, Klinikum Fulda gAG, Fulda, Germany
    Clin Cancer Res 12:5040-6. 2006
    ..We examined the usefulness of quantitative methylation analysis with a new set of p53 target genes for determining the clinical outcome and aggressiveness of the tumor disease...
  9. pmc Methylation of tumour suppressor genes APAF-1 and DAPK-1 and in vitro effects of demethylating agents in bladder and kidney cancer
    F Christoph
    Department of Urology, Charite Campus Benjamin Franklin, Universitatsmedizin Berlin, Hindenburgdamm 30, Berlin 12200, and Institute of Pathoogy, University Hospital Hamburg Eppendorf, Germany
    Br J Cancer 95:1701-7. 2006
    ..In conclusion, demethylating agents effectively retard growth of TCC and RCC cell lines. Methylation level analysis of specific genes has the potential for further tumour characterisation in TCC and RCC...
  10. doi request reprint Comparative promoter methylation analysis of p53 target genes in urogenital cancers
    Frank Christoph
    Department of Urology, Charite, Universitatsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany
    Urol Int 80:398-404. 2008
    ....
  11. ncbi request reprint A gene expression profile of tumor suppressor genes commonly methylated in bladder cancer
    Frank Christoph
    Department of Urology, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, Germany
    J Cancer Res Clin Oncol 133:343-9. 2007
    ....
  12. doi request reprint Expression parameters of the polycomb group proteins BMI1, SUZ12, RING1 and CBX7 in urothelial carcinoma of the bladder and their prognostic relevance
    S Hinz
    Department of Urology, Charite Universitatsmedizin Berlin, Berlin, Germany
    Tumour Biol 29:323-9. 2008
    ....
  13. ncbi request reprint EZH2 polycomb transcriptional repressor expression correlates with methylation of the APAF-1 gene in superficial transitional cell carcinoma of the bladder
    S Hinz
    Department of Urology, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany
    Tumour Biol 28:151-7. 2007
    ..Moreover, these data present first evidence that APAF-1 methylation is related to transcriptional activity of EZH2 expression in early-stage tumor disease of the bladder...
  14. pmc Quantitative real-time RT-PCR of CD24 mRNA in the detection of prostate cancer
    M Schostak
    Department of Urology, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Germany
    BMC Urol 6:7. 2006
    ..We tested the usefulness of real-time RT-PCR for specific and sensitive detection of CD24 transcripts as a supplementary measure for discriminating between malignant and benign lesions in prostatic tissues...
  15. doi request reprint [Testicular cancer - explanatory models for high cisplatin chemosensibility and new therapeutic options]
    J Ebbing
    Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Berlin
    Aktuelle Urol 39:429-35. 2008
    ..Furthermore, the current data on alternative chemotherapies as well as of molecular, molecular-genetic and pharmacogenetic therapeutic concepts are explored. Data were obtained from researches in Medline of the Pubmed database...
  16. ncbi request reprint Quantitative detection of cytokeratin 20 mRNA expression in bladder carcinoma by real-time reverse transcriptase-polymerase chain reaction
    F Christoph
    Department of Urology, Charite Campus Benjamin Franklin, Universitatsmedizin Berlin, Berlin, Germany
    Urology 64:157-61. 2004
    ....
  17. ncbi request reprint Kinetic fluorescence RT-PCR is highly sensitive for detection of germ-cell-tumor-specific transcripts in peripheral blood
    M Schrader
    Department of Urology, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, D 12200 Berlin, Germany
    Int J Mol Med 16:143-7. 2005
    ..With high specificity, its sensitivity is higher than that of the corresponding serum tumor marker (82.92% vs 48.72%)...
  18. ncbi request reprint [New concept minimizes bleeding in radical retropubic prostatectomy]
    M Schostak
    Urologische Klinik und Poliklinik, Charite Campus Benjamin Franklin, Universitatsmedizin, Berlin
    Urologe A 44:1332-6. 2005
    ....
  19. ncbi request reprint [Rectal perforation as a late complication of ProACT implantation]
    C Kempkensteffen
    Urologische Klinik und Hochschulambulanz, Charite, Campus Benjamin Franklin, Universitatsmedizin, Hindenburgdamm 30, 12200 Berlin
    Urologe A 45:865-7. 2006
    ..We report the case of a rectal perforation as a late complication of the ProACT procedure after prostatectomy and adjuvant radiotherapy. To the best of our knowledge this complication has not been described before...
  20. ncbi request reprint Long-term efficacy of tolterodine and patient compliance in pediatric patients with neurogenic detrusor overactivity
    F Christoph
    Department of Urology, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany
    Urol Int 79:55-9. 2007
    ..We investigated the effects of standard oral anticholinergic treatment with tolterodine in children with neurogenic bladder over a 5-year follow-up period and focused on treatment satisfaction, patient compliance and urodynamic parameters...
  21. ncbi request reprint Living donor nephrectomy in an open technique; a long-term analysis of donor outcome
    M Schostak
    Department of Urology, Charite Universitatsmedizin Berlin Campus Benjamin Franklin, Berlin, Germany
    Transplant Proc 35:2096-8. 2003
  22. doi request reprint [Expression levels of the IAP antagonists XAF1, Smac/DIABLO and HtrA2 in testicular germ cell tumours]
    C Kempkensteffen
    Charité Universitätsmedizin Berlin Campus Mitte, Abteilung für Urologie, Berlin
    Aktuelle Urol 39:436-41. 2008
    ..We examined the mRNA-expression of these pro-apoptotic parameters in testicular germ cell tumors (TGCT) and normal testicular tissue and correlated their expression levels to clinicopathological tumour features...
  23. ncbi request reprint [Prostate biopsy -- practical examination of the adequacy of Chen's virtual strategy]
    M Schostak
    Urologische Klinik und Poliklinik der Charité Campus Benjamin Franklin, Universitatsmedizin Berlin
    Aktuelle Urol 36:149-53. 2005
    ..Chen et al. found ten "ideal" biopsy sites using a computer model. This study examines the clinical value of this variation of number and localisation of biopsies...
  24. ncbi request reprint Expression levels of the mitochondrial IAP antagonists Smac/DIABLO and Omi/HtrA2 in clear-cell renal cell carcinomas and their prognostic value
    Carsten Kempkensteffen
    Department of Urology, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, Germany
    J Cancer Res Clin Oncol 134:543-50. 2008
    ..This study characterized the mRNA expression levels and evaluated the prognostic effect of the mitochondrial inhibitor of apoptosis antagonists Smac/DIABLO and Omi/HtrA2 in tumor tissue from clear-cell RCC patients...
  25. doi request reprint Chemokine receptor CCR6 expression level and aggressiveness of prostate cancer
    Pirus Ghadjar
    Department of Hematology, Medical Oncology and Transfusion Medicine, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12200, Berlin, Germany
    J Cancer Res Clin Oncol 134:1181-9. 2008
    ..This study was performed to investigate a potential relationship between CCR6 and CCL20 expression and features of human prostate cancer (PCA) at time of primary treatment...
  26. doi request reprint Expression of splicing variants of the inhibitor of apoptosis livin in testicular germ cell tumors
    Carsten Kempkensteffen
    Department of Urology, Charite, University Medicine Berlin, Berlin, Germany
    Tumour Biol 29:76-82. 2008
    ..Considering that livin expression is restricted to malignant testicular tissue, it appears reasonable to conduct further investigations regarding its targeted inhibition in TGCT...
  27. ncbi request reprint Expression of the polycomb group protein EZH2 and its relation to outcome in patients with urothelial carcinoma of the bladder
    Stefan Hinz
    Department of Urology, Universitatsmedizin Berlin, Charite Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, Germany
    J Cancer Res Clin Oncol 134:331-6. 2008
    ..This study was done to examine a potential correlation of EZH2 mRNA expression with clinicopathological parameters and outcome in patients with urothelial carcinoma (UC) of the bladder...
  28. doi request reprint Germ cell tumors of the gonads: a selective review emphasizing problems in drug resistance and current therapy options
    Mark Schrader
    Department of Urology, Charite Universitatsmedizin, Freie Universitat Berlin, Berlin, Germany
    Oncology 76:77-84. 2009
    ..This review article summarizes theoretical models for the high chemotherapy sensitivity of germ cell tumors and points out new therapeutic prospects...
  29. doi request reprint Expression of Mcl-1 splicing variants in clear-cell renal cancer and their correlation with histopathological parameters and prognosis
    Carsten Kempkensteffen
    Department of Urology, Charite Universitatsmedizin Berlin, Berlin, Germany
    Tumour Biol 30:73-9. 2009
    ....
  30. ncbi request reprint Expression of the apoptosis inhibitor livin in renal cell carcinomas: correlations with pathology and outcome
    Carsten Kempkensteffen
    Department of Urology, Charite, Universitatsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany
    Tumour Biol 28:132-8. 2007
    ..Our findings suggest that livin expression in RCC is not of prognostic relevance. Further studies to clarify the role of livin expression in RCC and its potential value as a target for immune-mediated tumor destruction are warranted...
  31. ncbi request reprint Gene expression and promoter methylation of the XIAP-associated Factor 1 in renal cell carcinomas: correlations with pathology and outcome
    Carsten Kempkensteffen
    Department of Urology, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, D 12200 Berlin, Germany
    Cancer Lett 254:227-35. 2007
    ..Promoter methylation may be one, but probably not the essential mechanism for transcriptional downregulation of the XAF1 gene in RCC...
  32. ncbi request reprint The equilibrium of XIAP and Smac/DIABLO expression is gradually deranged during the development and progression of testicular germ cell tumours
    Carsten Kempkensteffen
    Department of Urology, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany
    Int J Androl 30:476-83. 2007
    ..Thus the expression of proapoptotic Smac/DIABLO is lowest in NSGCT and stage III tumours...
  33. ncbi request reprint Quantitative analysis of survivin mRNA expression in urine and tumor tissue of bladder cancer patients and its potential relevance for disease detection and prognosis
    Steffen Weikert
    Department of Urology, Charite, Universitaetsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany
    Int J Cancer 116:100-4. 2005
    ..When analyzed by RT-PCR in urine, survivin is a highly specific biomarker for TCC detection...
  34. ncbi request reprint Quantitative evaluation of telomerase subunits in urine as biomarkers for noninvasive detection of bladder cancer
    Steffen Weikert
    Department of Urology, Charite Universitatsmedizin Berlin, Campus B Franklin, Berlin, Germany
    Int J Cancer 117:274-80. 2005
    ..These data suggest that quantitative hTR analysis is the most accurate telomerase-based test for bladder cancer detection and has the potential to replace cytology as a noninvasive biomarker for disease diagnosis and follow-up...
  35. ncbi request reprint New perioperative management reduces bleeding in radical retropubic prostatectomy
    Martin Schostak
    Department of Urology, Charite Campus Benjamin Franklin, Universitatsmedizin Berlin, Germany
    BJU Int 96:316-9. 2005
    ..To describe the effect of modifications to radical retropubic prostatectomy (RRP, known to be associated with severe bleeding) on blood loss in a retrospective analysis comparing RRPs by one experienced surgeon before and after the changes...
  36. ncbi request reprint Quantification of survivin mRNA in testes of infertile patients and in testicular germ cell tumours: high levels of expression associated with normal spermatogenesis
    Steffen Weikert
    Department of Urology, Charite Universitatsmedizin Berlin, Berlin, Germany
    Int J Androl 28:224-9. 2005
    ..Its downregulation in spermatogenic disorders indicates that survivin may contribute to the normal balance between germ cell proliferation and apoptosis. In TGCTs, survivin expression appears to be lost with somatic differentiation...
  37. ncbi request reprint Acucise endopyelotomy: a technique with limited efficacy for primary ureteropelvic junction obstruction in adults
    Steffen Weikert
    Department of Urology, Charite, Campus Benjamin Franklin, Berlin, Germany
    Int J Urol 12:864-8. 2005
    ..To retrospectively evaluate the ef fi cacy of Acucise endopyelotomy in a series of patients with primary ureteropelvic junction obstruction (UPJO)...
  38. ncbi request reprint Testicular expression of survivin and human telomerase reverse transcriptase (hTERT) associated with spermatogenic function in infertile patients
    Steffen Weikert
    Department of Urology, Charite Universitatsmedizin Berlin, Campus B Franklin, Hindenburgdamm 30, D 12200 Berlin, Germany
    Asian J Androl 8:95-100. 2006
    ..To characterize the coexpression of survivin, an inhibitor of apoptosis (IAF), and human telomerase reverse transcriptase (hTERT) in human testes with varying spermatogenic function...
  39. ncbi request reprint Expression levels of the EZH2 polycomb transcriptional repressor correlate with aggressiveness and invasive potential of bladder carcinomas
    Steffen Weikert
    Charite University Medicine in Berlin, Campus Benjamin Franklin, Department of Urology, Hindenburgdamm 30, D 12200 Berlin, Germany
    Int J Mol Med 16:349-53. 2005
    ..In conclusion, expression levels of EZH2 are elevated in aggressive and invasive urothelial carcinomas, suggesting that deregulated EZH2 expression may be involved in the progression of bladder tumors...
  40. ncbi request reprint Epigenetic silencing of the putative tumor suppressor gene testisin in testicular germ cell tumors
    Carsten Kempkensteffen
    Department of Urology, Charite, Campus Benjamin Franklin, Universitatsmedizin Berlin, Hindenburgdamm 30, 12200, Berlin, Germany
    J Cancer Res Clin Oncol 132:765-70. 2006
    ..This study aimed at identifying the CpG sites relevant for testisin gene silencing when methylated and evaluating the potential of aberrant methylation as a biomarker in TGCT...
  41. ncbi request reprint Expression parameters of the inhibitors of apoptosis cIAP1 and cIAP2 in renal cell carcinomas and their prognostic relevance
    Carsten Kempkensteffen
    Department of Urology, Charite Campus Benjamin Franklin, Universitatsmedizin Berlin, Berlin, Germany
    Int J Cancer 120:1081-6. 2007
    ..001). The results of uni- and multivariate analysis suggest a prognostic value of cIAP1 expression for RCC patients, downregulation indicating an aggressive, potentially lethal phenotype...
  42. ncbi request reprint Optimizing local anesthesia during 10-core biopsy of the prostate
    M Schostak
    Department of Urology, University Hospital Benjamin Franklin, Freie Universitat, Berlin, Germany
    Urology 60:253-7. 2002
    ..Reports thus far have shown a high variability in assessing the pain intensity of prostate biopsies and the effectiveness of anesthesia...
  43. ncbi request reprint Prostate cancer metastatic to the stomach
    F Christoph
    Department of Urology, University Hospital Benjamin Franklin, Free University of Berlin, Berlin, Germany
    Urology 63:778-9. 2004
    ..Computed tomography and bone scan revealed retroperitoneal lymphadenopathy and bone metastasis. Cranial computed tomography was negative for metastasis but upper endoscopy and biopsy revealed a metastatic lesion from prostate cancer...
  44. ncbi request reprint Body mass index does not affect systematic D2 lymph node dissection and postoperative morbidity in gastric cancer patients
    Stephan Gretschel
    Department of Surgery and Surgical Oncology, Humboldt University, Charite, Campus Berlin Buch, Robert Rössle Hospital, HELIOS Klinikum, Berlin, Germany
    Ann Surg Oncol 10:363-8. 2003
    ..Several prospective European trials attained contradictory results. A generally increased body mass index (BMI) of the European patients was assumed to be one of the major causes for postoperative morbidity...
  45. ncbi request reprint Urine telomerase and bladder cancer detection
    Steffen Weikert
    JAMA 295:998-9; author reply 999. 2006