Frank Buttgereit

Summary

Affiliation: Humboldt University
Country: Germany

Publications

  1. doi request reprint Delayed-release prednisone - a new approach to an old therapy
    Frank Buttgereit
    Charite University Medicine, Department of Rheumatology and Clinical Immunology, Chariteplatz 1, 10117 Berlin, Germany
    Expert Opin Pharmacother 14:1097-106. 2013
  2. ncbi request reprint A fresh look at glucocorticoids how to use an old ally more effectively
    Frank Buttgereit
    Department of Rheumatology and Clinical Immunology, Charite Universitatsmedizin Berlin, Campus Mitte, Chariteplatz 1, Berlin, Germany
    Bull NYU Hosp Jt Dis 70:26-9. 2012
  3. pmc Low-dose prednisone chronotherapy for rheumatoid arthritis: a randomised clinical trial (CAPRA-2)
    Frank Buttgereit
    Department of Rheumatology and Clinical Immunology, Charite University Medicine, Berlin 10117, Germany
    Ann Rheum Dis 72:204-10. 2013
  4. doi request reprint Symptom control with low-dose glucocorticoid therapy for rheumatoid arthritis
    John R Kirwan
    Academic Rheumatology Unit, Bristol Royal Infirmary, Bristol, UK
    Rheumatology (Oxford) 51:iv14-20. 2012
  5. pmc The association between rheumatoid arthritis and periodontal disease
    Jacqueline Detert
    Department of Rheumatology and Clinical Immunology, Charite Universitatsmedizin Berlin, Campus Mitte, Chariteplatz 1, 10117 Berlin, Germany
    Arthritis Res Ther 12:218. 2010
  6. pmc Targeting pathophysiological rhythms: prednisone chronotherapy shows sustained efficacy in rheumatoid arthritis
    Frank Buttgereit
    Department of Rheumatology and Clinical Immunology, Charite University Medicine Berlin, Chariteplatz 1, 10117 Berlin, Germany
    Ann Rheum Dis 69:1275-80. 2010
  7. doi request reprint Efficacy of modified-release versus standard prednisone to reduce duration of morning stiffness of the joints in rheumatoid arthritis (CAPRA-1): a double-blind, randomised controlled trial
    Frank Buttgereit
    Department of Rheumatology and Clinical Immunology, Charite University Medicine, Berlin, Germany
    Lancet 371:205-14. 2008
  8. ncbi request reprint [Disease-modifying effects of glucocorticoids in rheumatoid arthritis]
    F Buttgereit
    Medizinische Klinik mit Schwerpunkt Rheumatologie und Klinische Immunologie, Charite Campus Mitte, Charite Universitatsmedizin Berlin, Chariteplatz 1, 10117 Berlin, Deutschland
    Z Rheumatol 66:522-4. 2007
  9. doi request reprint How should impaired morning function in rheumatoid arthritis be treated?
    F Buttgereit
    Department of Rheumatology and Clinical Immunology, Charite University Medicine, Berlin, Germany
    Scand J Rheumatol Suppl 125:28-39. 2011
  10. ncbi request reprint New glucocorticoids on the horizon: repress, don't activate!
    In Ho Song
    Department of Rheumatology and Clinical Immunology, Charite University Hospital, Berlin, Germany
    J Rheumatol 32:1199-1207. 2005

Detail Information

Publications103 found, 100 shown here

  1. doi request reprint Delayed-release prednisone - a new approach to an old therapy
    Frank Buttgereit
    Charite University Medicine, Department of Rheumatology and Clinical Immunology, Chariteplatz 1, 10117 Berlin, Germany
    Expert Opin Pharmacother 14:1097-106. 2013
    ..The most advanced approach, already licensed for clinical use, is delayed-release prednisone...
  2. ncbi request reprint A fresh look at glucocorticoids how to use an old ally more effectively
    Frank Buttgereit
    Department of Rheumatology and Clinical Immunology, Charite Universitatsmedizin Berlin, Campus Mitte, Chariteplatz 1, Berlin, Germany
    Bull NYU Hosp Jt Dis 70:26-9. 2012
    ..Very recently, DR prednisone was also approved in the United States to treat rheumatologic conditions such as RA, polymyalgia rheumatica and psoriatic arthritis, as well as respiratory conditions such as COPD and asthma...
  3. pmc Low-dose prednisone chronotherapy for rheumatoid arthritis: a randomised clinical trial (CAPRA-2)
    Frank Buttgereit
    Department of Rheumatology and Clinical Immunology, Charite University Medicine, Berlin 10117, Germany
    Ann Rheum Dis 72:204-10. 2013
    ..To assess the efficacy and safety of low-dose prednisone chronotherapy using a new modified-release (MR) formulation for the treatment of rheumatoid arthritis (RA)...
  4. doi request reprint Symptom control with low-dose glucocorticoid therapy for rheumatoid arthritis
    John R Kirwan
    Academic Rheumatology Unit, Bristol Royal Infirmary, Bristol, UK
    Rheumatology (Oxford) 51:iv14-20. 2012
    ..Furthermore, there are some indications that administration of glucocorticoid in accordance with the natural circadian rhythm may improve hypothalamic-pituitary-adrenal axis function. Further work is required to confirm these findings...
  5. pmc The association between rheumatoid arthritis and periodontal disease
    Jacqueline Detert
    Department of Rheumatology and Clinical Immunology, Charite Universitatsmedizin Berlin, Campus Mitte, Chariteplatz 1, 10117 Berlin, Germany
    Arthritis Res Ther 12:218. 2010
    ....
  6. pmc Targeting pathophysiological rhythms: prednisone chronotherapy shows sustained efficacy in rheumatoid arthritis
    Frank Buttgereit
    Department of Rheumatology and Clinical Immunology, Charite University Medicine Berlin, Chariteplatz 1, 10117 Berlin, Germany
    Ann Rheum Dis 69:1275-80. 2010
    ....
  7. doi request reprint Efficacy of modified-release versus standard prednisone to reduce duration of morning stiffness of the joints in rheumatoid arthritis (CAPRA-1): a double-blind, randomised controlled trial
    Frank Buttgereit
    Department of Rheumatology and Clinical Immunology, Charite University Medicine, Berlin, Germany
    Lancet 371:205-14. 2008
    ..We aimed to assess the efficacy and safety of a new modified-release prednisone tablet compared with immediate-release prednisone in patients with this disease...
  8. ncbi request reprint [Disease-modifying effects of glucocorticoids in rheumatoid arthritis]
    F Buttgereit
    Medizinische Klinik mit Schwerpunkt Rheumatologie und Klinische Immunologie, Charite Campus Mitte, Charite Universitatsmedizin Berlin, Chariteplatz 1, 10117 Berlin, Deutschland
    Z Rheumatol 66:522-4. 2007
    ..For these reasons, glucocorticoids can be considered DMARDs if they are used to treat patients suffering from early RA and, according to the current knowledge, are used in combination with other DMARDs...
  9. doi request reprint How should impaired morning function in rheumatoid arthritis be treated?
    F Buttgereit
    Department of Rheumatology and Clinical Immunology, Charite University Medicine, Berlin, Germany
    Scand J Rheumatol Suppl 125:28-39. 2011
    ..Clinical studies suggest that morning stiffness in patients with RA could be treated successfully with the use of low-dose modified-release prednisone...
  10. ncbi request reprint New glucocorticoids on the horizon: repress, don't activate!
    In Ho Song
    Department of Rheumatology and Clinical Immunology, Charite University Hospital, Berlin, Germany
    J Rheumatol 32:1199-1207. 2005
    ..Finally, we describe the state of research on membrane-bound glucocorticoid receptors as possible further targets for specific glucocorticoid actions...
  11. pmc Standardised nomenclature for glucocorticoid dosages and glucocorticoid treatment regimens: current questions and tentative answers in rheumatology
    F Buttgereit
    Department of Rheumatology and Clinical Immunology, Charite University Hospital, Humboldt University, Berlin, Germany
    Ann Rheum Dis 61:718-22. 2002
    ..A question-answer rationale presentation style has been chosen to convey the messages, to summarise the meeting in a readable format, and to avoid dogmatism...
  12. ncbi request reprint Equivalent doses and relative drug potencies for non-genomic glucocorticoid effects: a novel glucocorticoid hierarchy
    F Buttgereit
    Department of Rheumatology and Clinical Immunology, Charite University Hospital, Humboldt University Berlin, Germany
    Biochem Pharmacol 58:363-8. 1999
    ..Examples are the choice between methylprednisolone and prednisolone in pulse therapy, and the completely different clinical usage of dexamethasone and betamethasone, despite their similar affinities for nuclear receptors...
  13. ncbi request reprint Glucocorticoids in the treatment of rheumatic diseases: an update on the mechanisms of action
    Frank Buttgereit
    Department of Rheumatology and Clinical Immunology, Charite University Hospital, Schumannstrasse 20 21, 10117 Berlin, Germany
    Arthritis Rheum 50:3408-17. 2004
  14. ncbi request reprint The molecular basis for the effectiveness, toxicity, and resistance to glucocorticoids: focus on the treatment of rheumatoid arthritis
    F Buttgereit
    Department of Rheumatology and Clinical Immunology, Charite University Hospital, Berlin, Germany
    Scand J Rheumatol 34:14-21. 2005
    ....
  15. ncbi request reprint Therapeutically targeting lymphocyte energy metabolism by high-dose glucocorticoids
    F Buttgereit
    Department of Rheumatology and Clinical Immunology, Charite University Hospital, Humboldt University of Berlin, 10117, Berlin, Germany
    Biochem Pharmacol 59:597-603. 2000
    ....
  16. ncbi request reprint Mechanisms and clinical relevance of nongenomic glucocorticoid actions
    F Buttgereit
    Department of Rheumatology and Clinical Immunology, Charite University Hospital, Schumannstrasse 20 21, 10117 Berlin, Germany
    Z Rheumatol 59:II/119-23. 2000
    ..It is proposed that the additional therapeutic benefit of higher doses is obtained via these nongenomic effects...
  17. ncbi request reprint Gastrointestinal toxic side effects of nonsteroidal anti-inflammatory drugs and cyclooxygenase-2-specific inhibitors
    F Buttgereit
    Department of Rheumatology and Clinical Immunology, Charite University Hospital, Humboldt University, FB, GRB, Berlin, Germany
    Am J Med 110:13S-9S. 2001
    ..Finally, we offer recommendations on the clinical use of these drugs, emphasizing the need to balance clinical effectiveness with the avoidance of potential gastrointestinal side effects...
  18. ncbi request reprint Rapid glucocorticoid effects on immune cells
    Frank Buttgereit
    Department of Rheumatology and Clinical Immunology, Charite University Hospital, Humboldt University, Berlin, Germany
    Steroids 67:529-34. 2002
    ..This article gives a detailed presentation of the data available at present concerning rapid glucocorticoid effects on immune cells...
  19. doi request reprint Inflammatory phase of bone healing initiates the regenerative healing cascade
    Katharina Schmidt-Bleek
    Julius Wolff Institut and Center for Musculoskeletal Surgery, Charite Universitatsmedizin Berlin, Augustenburger Platz 1, Berlin, Germany
    Cell Tissue Res 347:567-73. 2012
    ..In conclusion, identifying beneficial aspects may lead to promising therapeutical approaches that might benefit further by eliminating the unfavorable factors...
  20. doi request reprint Rimexolone inhibits proliferation, cytokine expression and signal transduction of human CD4+ T-cells
    Cornelia M Spies
    Department of Rheumatology and Clinical Immunology, Charite University Hospital, Campus Mitte, Chariteplatz 1, Berlin, Germany
    Immunol Lett 131:24-32. 2010
    ..It is implied that these effects contribute to the well-known beneficial anti-inflammatory and immunomodulatory effects of glucocorticoid therapy...
  21. doi request reprint High-sensitivity immunofluorescence staining: a comparison of the liposome procedure and the FASER technique on mGR detection
    Cindy Strehl
    Department of Rheumatology and Clinical Immunology, Charite University Hospital, Berlin, Germany
    J Fluoresc 23:509-18. 2013
    ..Our data demonstrate the FASER technique to be more sensitive and also more specific for the detection of mGR as compared to the liposome technique. However, both methods have advantages and disadvantages which are discussed in detail...
  22. doi request reprint Preoperative irradiation for the prevention of heterotopic ossification induces local inflammation in humans
    Paula Hoff
    Department of Rheumatology and Clinical Immunology, Charite University Hospital, Berlin, Germany
    Bone 55:93-101. 2013
    ..This increase of inflammatory activity together with the observed suppression in VEGF secretion may contribute to the prevention of HO...
  23. pmc Osteoarthritis synovial fluid activates pro-inflammatory cytokines in primary human chondrocytes
    Paula Hoff
    Department of Rheumatology and Clinical Immunology, Charite University Hospital, Berlin, Germany
    Int Orthop 37:145-51. 2013
    ..The aim of the present study was to investigate the effects of the synovial fluid environment of OA patients in comparison with synovial fluids of RA patients on human chondrocytes in vitro...
  24. doi request reprint Pathophysiological hypoxia affects the redox state and IL-2 signalling of human CD4+ T cells and concomitantly impairs survival and proliferation
    Timo Gaber
    Department of Rheumatology and Clinical Immunology, Charite University Hospital, Berlin, Germany
    Eur J Immunol 43:1588-97. 2013
    ..The level of iROS may therefore act as a mediator of immune functions leading to down-regulation of long-term T-cell activity in inflamed tissues...
  25. ncbi request reprint Limited use of antiseptics in septic surgery
    Eric Röhner
    Department of Orthopaedic, Center for Musculoskeletal Surgery, Charit e University Hospital, Berlin, Germany
    J Invest Surg 25:311-6. 2012
    ..Conversely, hydrogen peroxide induces early and later stages of apoptosis on primary human chondrocytes in vitro...
  26. doi request reprint Macrophage migration inhibitory factor counterregulates dexamethasone-mediated suppression of hypoxia-inducible factor-1 alpha function and differentially influences human CD4+ T cell proliferation under hypoxia
    Timo Gaber
    Department of Rheumatology and Clinical Immunology, Charite University Hospital, 10117 Berlin, Germany
    J Immunol 186:764-74. 2011
    ..Therefore, we suggest that HIF and/or MIF could be useful targets to optimize GC therapy when treating inflammation...
  27. ncbi request reprint Membrane glucocorticoid receptor expression on peripheral blood mononuclear cells in patients with ankylosing spondylitis
    Anita B Tryc
    Department of Rheumatology and Clinical Immunology, Charite University Hospital, Campus Mitte, Chariteplatz 1, 10117 Berlin, Germany
    J Rheumatol 33:2249-53. 2006
    ..To investigate the expression of membrane glucocorticoid receptors (mGCR) on peripheral blood mononuclear cells (PBMC) in patients with ankylosing spondylitis (AS)...
  28. doi request reprint Human immune cells' behavior and survival under bioenergetically restricted conditions in an in vitro fracture hematoma model
    Paula Hoff
    Department of Rheumatology and Clinical Immunology, Charite University Hospital, Berlin, Germany
    Cell Mol Immunol 10:151-8. 2013
    ....
  29. doi request reprint Inflammatory synovial fluid microenvironment drives primary human chondrocytes to actively take part in inflammatory joint diseases
    Eric Röhner
    Department of Traumatology and Orthopedics, Charite University Hospital, Berlin, Germany
    Immunol Res 52:169-75. 2012
    ..The inflammatory synovial fluid microenvironment mediates apoptosis and cell death of chondrocytes. Moreover, in terms of cytokine secretion, it also induces an active participation of chondrocytes in ongoing inflammation...
  30. doi request reprint Origin and functional activity of the membrane-bound glucocorticoid receptor
    Cindy Strehl
    Charité University Hospital and German Rheumatism Research Centre, Berlin, Germany
    Arthritis Rheum 63:3779-88. 2011
    ..Most likely, membrane-bound GRs (mGR) are involved in nongenomic GC signaling. The aim of this study was to investigate the origin and functional activity of mGR...
  31. doi request reprint Human CD4(+) T cells maintain specific functions even under conditions of extremely restricted ATP production
    Robert Tripmacher
    Department of Rheumatology and Clinical Immunology, Charite University Medicine, Berlin, Germany
    Eur J Immunol 38:1631-42. 2008
    ..Our data demonstrate an unexpectedly high, clinically relevant adaptive potential of human CD4(+) T cells to maintain specific functions even under severely impaired bioenergetic conditions...
  32. ncbi request reprint Nonsteroidal antiinflammatory drugs and a selective cyclooxygenase 2 inhibitor uncouple mitochondria in intact cells
    Manja M Krause
    University Hospital Charite, Humboldt University Berlin, Berlin, Germany
    Arthritis Rheum 48:1438-44. 2003
    ..We investigated the occurrence of NSAID-induced uncoupling of mitochondria in intact cells (rat thymocytes) compared with the effects of a selective cyclooxygenase 2 (COX-2) inhibitor...
  33. pmc Human early fracture hematoma is characterized by inflammation and hypoxia
    Paula Kolar
    Department of Rheumatology and Clinical Immunology, Charite University Hospital, Chariteplatz 1, 10117 Berlin, Germany
    Clin Orthop Relat Res 469:3118-26. 2011
    ..An effective immune system, especially during the inflammatory phase, putatively influences the quality and likelihood of bone healing. If and how this is reflected within the initial fracture hematoma is unclear...
  34. ncbi request reprint Potencies of topical glucocorticoids to mediate genomic and nongenomic effects on human peripheral blood mononuclear cells
    Lydia Naumann
    Department of Medicine Rheumatology and Clinical Immunology, Charite University Hospital, Schumannstrasse 20 21, 10117 Berlin, Germany
    Biochem Pharmacol 71:530-9. 2006
    ....
  35. doi request reprint Pharmacology of glucocorticoids in rheumatoid arthritis
    Cornelia M Spies
    Department of Rheumatology and Clinical Immunology, Charite University Hospital, Campus Mitte, Chariteplatz 1, 10117 Berlin, Germany
    Curr Opin Pharmacol 10:302-7. 2010
    ..This short review summarises the current knowledge in this regard, with particular emphasis on recently published articles...
  36. doi request reprint Adaptation of human CD4+ T cells to pathophysiological hypoxia: a transcriptome analysis
    Timo Gaber
    Department of Rheumatology and Clinical Immunology, Charite University Hospital, Chariteplatz 1, 10117 Berlin, Germany
    J Rheumatol 36:2655-69. 2009
    ..Inflamed tissues are usually characterized by low oxygen levels. We investigated whether pathophysiological hypoxia (pO(2) < 1%) as found in the rheumatoid synovium modulates the transcriptome of human CD4+ T cells...
  37. ncbi request reprint Non-genomic glucocorticoid effects to provide the basis for new drug developments
    In Ho Song
    Department of Rheumatology and Clinical Immunology, Charite University Hospital, Schumannstrasse 20 21, 10117 Berlin, Germany
    Mol Cell Endocrinol 246:142-6. 2006
    ..The clinical use of the latter two mechanisms is still speculative, but intriguing ideas are being discussed in this regard...
  38. pmc Hypoxia promotes osteogenesis but suppresses adipogenesis of human mesenchymal stromal cells in a hypoxia-inducible factor-1 dependent manner
    Markus Wagegg
    Department of Rheumatology and Clinical Immunology, Charite University Hospital, Berlin, Germany
    PLoS ONE 7:e46483. 2012
    ..Therefore, we analyzed the impact of hypoxia and HIF-1 on the competitive differentiation potential of hMSCs towards adipogenic and osteogenic lineages...
  39. doi request reprint Hypothalamus-pituitary-adrenal axis function in patients with rheumatoid arthritis treated with nighttime-release prednisone
    Rieke Alten
    Department of Internal Medicine II, Rheumatology, Clinical Immunology, Schlosspark Klinik, Teaching Hospital, Charite University Medicine, Berlin, Germany
    J Rheumatol 37:2025-31. 2010
    ..This consisted of a 3-month active-controlled phase and a 9-month open-label extension with MR prednisone including patients previously treated with prednisone (ClinicalTrials.gov number NCT00146640)...
  40. doi request reprint Genomic and nongenomic effects of glucocorticoids
    Cindy Stahn
    Department of Rheumatology and Clinical Immunology, Charite University Hospital, Berlin, Germany
    Nat Clin Pract Rheumatol 4:525-33. 2008
    ..Increased understanding of these mechanisms of glucocorticoid action could enable the development of novel drugs with which to treat patients with inflammatory and autoimmune disease...
  41. doi request reprint The early fracture hematoma and its potential role in fracture healing
    Paula Kolar
    Department of Rheumatology and Clinical Immunology, Charite Universitatsmedizin Berlin, Berlin, Germany
    Tissue Eng Part B Rev 16:427-34. 2010
    ....
  42. doi request reprint Glucocorticoids
    Cornelia M Spies
    Department of Rheumatology and Clinical Immunology, Charite Universitatsmedizin Berlin, Campus Mitte, Berlin, Germany
    Best Pract Res Clin Rheumatol 25:891-900. 2011
    ..Improved knowledge of the immunomodulatory role of endogenous glucocorticoids has evolved, and we report on the therapeutic potential of targeting glucocorticoid pre-receptor metabolism for metabolic and inflammatory diseases...
  43. ncbi request reprint Optimised glucocorticoid therapy: the sharpening of an old spear
    Frank Buttgereit
    Department of Rheumatology and Clinical Immunology, Charite University Hospital, Berlin, Germany
    Lancet 365:801-3. 2005
    ..These drugs are also relatively inexpensive, but it is their broad range of adverse reactions that continuously stimulate efforts to optimise glucocorticoid treatment...
  44. pmc Hypoxia inducible factor (HIF) in rheumatology: low O2! See what HIF can do!
    T Gaber
    Department of Rheumatology and Clinical Immunology, Charite University Hospital, Schumannstrasse 20 21, 10117 Berlin, Germany
    Ann Rheum Dis 64:971-80. 2005
    ....
  45. ncbi request reprint Membrane glucocorticoid receptors (mGCR) are expressed in normal human peripheral blood mononuclear cells and up-regulated after in vitro stimulation and in patients with rheumatoid arthritis
    Burkhard Bartholome
    Department of Rheumatology and Clinical Immunology, Charite University Hospital, Berlin, Germany
    FASEB J 18:70-80. 2004
    ..These receptors may reflect a feedback mechanism of the organism upon immunostimulation and/or play a role in pathogenesis...
  46. doi request reprint The impact of Porphyromonas gingivalis lipids on apoptosis of primary human chondrocytes
    Eric Röhner
    Department of Traumatology and Orthopaedics, Charite Universitatsmedizin, Berlin, Germany
    Connect Tissue Res 53:327-33. 2012
    ..gingivalis lipids was demonstrated. The present data demonstrate that P. gingivalis lipids promote apoptosis in primary human chondrocytes, and thereby may contribute to the joint damage seen in the pathogenesis of RA...
  47. doi request reprint Takayasu arteritis is characterised by disturbances of B cell homeostasis and responds to B cell depletion therapy with rituximab
    Bimba F Hoyer
    Department of Medicine Clinic for Rheumatology and Clinical Immunology, Charite Universitatsmedizin Berlin, Berlin, Germany
    Ann Rheum Dis 71:75-9. 2012
    ..Introduction Takayasu arteritis (TA) is a large vessel vasculitis involving the aorta and its major branches. T cell-mediated autoimmunity is thought to play a major role in its pathogenesis, while the role of B cells is still unclear...
  48. doi request reprint More night than day--circadian rhythms in polymyalgia rheumatica and ankylosing spondylitis
    Cornelia M Spies
    Department of Rheumatology and Clinical Immunology, Charite University Hospital, Campus Mitte, Berlin, Germany
    J Rheumatol 37:894-9. 2010
    ..This review summarizes the current knowledge on circadian rhythms in other rheumatic diseases, focusing on polymyalgia rheumatica and ankylosing spondylitis...
  49. ncbi request reprint Molecular mechanisms of glucocorticoid action and selective glucocorticoid receptor agonists
    Cindy Stahn
    Department of Rheumatology and Clinical Immunology, Charite University Hospital, Schumannstrasse 20 21, 10117 Berlin, Germany
    Mol Cell Endocrinol 275:71-8. 2007
    ..Here, we review the above-mentioned mechanisms of glucocorticoid action and give particular attention to the development of optimized glucocorticoids and SEGRAs...
  50. ncbi request reprint Effects of dexamethasone and celecoxib on calcium homeostasis and expression of cyclooxygenase-2 mRNA in MG-63 human osteosarcoma cells
    M Wiontzek
    Department of Rheumatology and Clinical Immunology and Deutsches Rheumaforschungszentrum DRFZ, Charite University Hospital, Humboldt University, Chariteplatz 1, 10117 Berlin, Germany
    Clin Exp Rheumatol 24:366-72. 2006
    ..They are also suggested to influence bone physiology and remodeling. Here we searched for effects of dexamethasone and celecoxib on crucial parameters of bone physiology that could be therapeutically relevant...
  51. ncbi request reprint Short-term effects of the 21-aminosteroid lazaroid tirilazad mesylate (PNU-74006F) and the pyrrolopyrimidine lazaroid PNU-101033E on energy metabolism of human peripheral blood mononuclear cells
    D Schmid
    Department of Medicine (Rheumatology, , Humboldt University, Berlin, Germany
    Biosci Rep 21:101-10. 2001
    ....
  52. ncbi request reprint Modulation of intracellular calcium signaling and mitochondrial function in cultured osteoblastic cells by dexamethasone and celecoxib during mechanical stimulation
    S Schuchmann
    Medizinische Klinik mit Schwerpunkt Rheumatologie und Klinische Immunologie, Universitatsklinikum Charite, Humboldt Universitat Berlin, Germany
    Clin Exp Rheumatol 22:184-96. 2004
    ..Evaluation of potentially therapeutically relevant effects of dexamethasone and celecoxib on crucial parameters of bone physiology during and following mechanical stimulation in cultured osteoblasts...
  53. doi request reprint Gene expression of catalytic proteasome subunits and resistance toward proteasome inhibition of B lymphocytes from patients with primary sjogren syndrome
    Lorena Martinez-Gamboa
    Rheumatology Research Laboratory, Department of Rheumatology and Clinical Immunology, Charite Universitatsmedizin Berlin, Germany
    J Rheumatol 40:663-73. 2013
    ..Dysregulation of proteasome subunit β1i expression has been shown in total blood mononuclear cells (PBMC) from patients with primary Sjögren syndrome (pSS), a B cell-driven systemic autoimmune disorder...
  54. ncbi request reprint Correlation of different bone markers with bone density in patients with rheumatic diseases on glucocorticoid therapy
    Konstanze Loddenkemper
    Department of Rheumatology and Clinical Immunology, Charité Universitätsmedizin Berlin Campus Charité Mitte, Charite University Hospital, Schumannstrasse 20 21, 10117 Berlin, Germany
    Rheumatol Int 26:331-6. 2006
    ....
  55. pmc Energy metabolism and rheumatic diseases: from cell to organism
    Cornelia M Spies
    Department of Rheumatology and Clinical Immunology, Charite University Medicine Berlin, Chariteplatz 1, 10117 Berlin, Germany
    Arthritis Res Ther 14:216. 2012
    ..We conclude that, on cellular and organism levels, a prolonged energy appeal reaction is an important factor of chronic inflammatory disease etiology...
  56. doi request reprint Induction therapy with adalimumab plus methotrexate for 24 weeks followed by methotrexate monotherapy up to week 48 versus methotrexate therapy alone for DMARD-naive patients with early rheumatoid arthritis: HIT HARD, an investigator-initiated study
    Jacqueline Detert
    Department of Rheumatology and Clinical Immunology, Charite Universitatsmedizin Berlin, Berlin, Germany
    Ann Rheum Dis 72:844-50. 2013
    ..To investigate the long-term effects of induction therapy with adalimumab (ADA) plus methotrexate (MTX) in comparison with placebo (PBO) plus MTX in DMARD-naïve patients with active early rheumatoid arthritis (RA)...
  57. doi request reprint Preferred use of polyhexanide in orthopedic surgery
    Eric Röhner
    Department of Traumatology and Orthopedics, Charite Universitatsmedizin, Berlin, Germany
    Orthopedics 34:e664-8. 2011
    ..The data show that polyhexanide promotes apoptosis on primary human chondrocytes in vitro, which may indicate the use of polyhexanide in septic joint surgery...
  58. ncbi request reprint [Selective COX-2 inhibition improves endothelial function in coronary artery disease]
    Olaf Schultz
    Universitatsklinikum Charite, Medizinische Universitätsklinik mit Schwerpunkt Rheumatologie, Schumannstrasse 20 21, 10117 Berlin, Germany
    Z Rheumatol 62:422-4. 2003
  59. ncbi request reprint Effects of tacrolimus, cyclosporin A and sirolimus on MG63 cells
    Dörte Krocker
    Center for Musculoskeletal Surgery, Charite, University Medicine Berlin, Berlin, Germany
    Transpl Int 19:563-9. 2006
    ..They do not have antiproliferative or toxic effects. We postulate that the shown changes of osteoblast differentiation cause post-transplantation disease...
  60. ncbi request reprint Tumoral calcinosis revisited: pathophysiology and treatment
    Gregor Möckel
    Orthopaedic Department, Humboldt University Berlin Charité, Berlin, Germany
    Rheumatol Int 25:55-9. 2005
    ..In view of the high risk of recurrence, local excision is a treatment procedure to be considered in exceptional cases only...
  61. ncbi request reprint Calcium, vitamin D and etidronate for the prevention and treatment of corticosteroid-induced osteoporosis in patients with rheumatic diseases
    K Loddenkemper
    Department of Rheumatology and Clinical Immunology, Charite University Hospital, Humboldt University of Berlin, Berlin, Germany
    Clin Exp Rheumatol 21:19-26. 2003
    ..At present there are no generally accepted guidelines for the prevention or treatment of steroid-induced osteoporosis...
  62. ncbi request reprint [Chrysiasis]
    K Loddenkemper
    Universitätsklinikum Charité Berlin Innere Klinik mit Schwerpunkt Rheumatologie und klinische Immunologie Schumannstr 20 21, 10117 Berlin, Germany
    Z Rheumatol 61:173-4. 2002
    ..Chrysiasis is a rare permanent pigmentation of the skin resulting from the parenteral administration of gold. The cause of the pigmentation is multifactorial and not fully established at the moment...
  63. doi request reprint Effects of hypoxia and/or lack of glucose on cellular energy metabolism and cytokine production in stimulated human CD4+ T lymphocytes
    R Dziurla
    Department of Rheumatology and Clinical Immunology, Charite University Hospital, Chariteplatz 1, Berlin, Germany
    Immunol Lett 131:97-105. 2010
    ..Hypoxia seems to facilitate inflammatory reactions and angiogenesis...
  64. ncbi request reprint Prevalence and clinical significance of anticardiolipin and anti-beta2-glycoprotein-I antibodies in patients with non-Hodgkin's lymphoma
    I Genvresse
    Internal Medicine, Hematology Oncology, Humboldt University, University Hospital Charite, Virchow Klinikum, Germany
    Eur J Haematol 68:84-90. 2002
    ..3%). Vessel compression by lymphoma but not elevated APA remains the main cause of thrombosis in NHL patients...
  65. ncbi request reprint Arterial thrombosis associated with anticardiolipin and anti-beta2-glycoprotein-I antibodies in patients with non-Hodgkin's lymphoma: a report of two cases
    I Genvresse
    Internal Medicine II Hematology Oncology, Humboldt University, University Hospital Charite, Berlin, Germany
    Eur J Haematol 65:344-7. 2000
    ....
  66. ncbi request reprint Fatal atypical T-cell proliferation associated with Epstein-Barr virus infection
    S Hauptmann
    Institute of Pathology and Department of Rheumatology, Charité Hospital Berlin, and Institute of Pathology, University Erlangen, Erlangen, Germany
    Br J Haematol 112:377-80. 2001
    ..The remarkable features of this case are (i) the occurrence in a Caucasian patient, (ii) the absence of detectable immunodeficiency, and (iii) the myocardial destruction by EBV-infected monoclonal T cells...
  67. doi request reprint Induced apoptosis of chondrocytes by Porphyromonas gingivalis as a possible pathway for cartilage loss in rheumatoid arthritis
    E Rohner
    Department of Rheumatology and Clinical Immunology, Charite University Hospital, Berlin, Germany
    Calcif Tissue Int 87:333-40. 2010
    ..The data show that P. gingivalis promotes early and later stages of apoptosis of primary human chondrocytes, which might contribute to the joint damage seen in the pathogenesis of RA...
  68. ncbi request reprint Methotrexate treatment in large vessel vasculitis and polymyalgia rheumatica
    C M Spies
    Department of Rheumatology and Clinical Immunology, Charite University Hospital, Campus Mitte, Berlin, Germany
    Clin Exp Rheumatol 28:S172-7. 2010
    ..Further attempts should be made for a better identification of patients with glucocorticoid-refractory courses and a more precise formulation of guidelines on indication, optimal dosing and duration...
  69. ncbi request reprint The influence of obesity on perioperative morbidity and mortality in revision total hip arthroplasty
    C Perka
    Orthopädische Klinik und Poliklinik der Charité, Berlin, Germany
    Arch Orthop Trauma Surg 120:267-71. 2000
    ..We conclude that obesity does not have any significant influence on perioperative morbidity and mortality but is clearly related to operation time and, therefore, to higher costs per operation...
  70. pmc Bioenergetics of immune cells to assess rheumatic disease activity and efficacy of glucocorticoid treatment
    A Kuhnke
    Department of Rheumatology and Clinical Immunology, Charite University Hospital, Humboldt University, Schumannstrasse 20 21, 10117 Berlin, Germany
    Ann Rheum Dis 62:133-9. 2003
    ..To investigate whether activity and glucocorticoid treatment of rheumatic diseases are reflected by selected parameters of cellular energy metabolism of peripheral blood mononuclear cells (PBMC)...
  71. doi request reprint [Pathogenesis of parodontitis in rheumatic diseases]
    J Detert
    Klinik mit Schwerpunkt Rheumatologie und klinische Immunologie, Charite Universitatsmedizin Berlin, Berlin, Deutschland
    Z Rheumatol 69:109-12, 114-6. 2010
    ..PD and rheumatologic diseases such as RA share many pathological aspects and immunological findings...
  72. pmc Membrane glucocorticoid receptors are down regulated by glucocorticoids in patients with systemic lupus erythematosus and use a caveolin-1-independent expression pathway
    C M Spies
    Department of Rheumatology and Clinical Immunology, Charite University Hospital, Campus Mitte, Berlin, Germany
    Ann Rheum Dis 65:1139-46. 2006
    ..Caveolin-1 is critical for the transport of plasma membrane oestrogen receptors to the cell surface...
  73. ncbi request reprint [Reduction of arthrosis associated knee pain through a single intra-articular injection of synthetic hyaluronic acid]
    D Krocker
    Centrum für Muskuloskeletale Chirurgie, Charite Universitatsmedizin Berlin, Chariteplatz 1, 10117, Berlin, Germany
    Z Rheumatol 65:327-31. 2006
    ..Clinical outcome using Durolane should be compared with the results of studies using hyaluronic acids or glucocorticoids...
  74. doi request reprint [Glucocorticoids in rheumatology]
    R Dziurla
    Charite Universitatsmedizin Berlin, Chariteplatz 1, 10117, Berlin
    Z Rheumatol 67:583-91; quiz 592. 2008
    ..The musculoskeletal, gastrointestinal, neuro-endocrino-immunological, opthalmological and neuropsychiatric systems are examples where adverse effects may occur...
  75. doi request reprint Effects of Porphyromonas gingivalis on cell cycle progression and apoptosis of primary human chondrocytes
    N Pischon
    Department of Periodontology, Charite Universitatsmedizin, Berlin, Campus Virchow, 13353 Berlin, Germany
    Ann Rheum Dis 68:1902-7. 2009
    ..It has been suggested that bacterial infections have a role in the pathogenesis of rheumatoid arthritis (RA). P gingivalis, a Gram-negative, anaerobic rod, is one of the major pathogens associated with periodontal disease...
  76. doi request reprint Periodontal disease in patients with ankylosing spondylitis
    N Pischon
    Department of Periodontology, Charite Universitatsmedizin Berlin, Campus Virchow, Augustenburger Platz 1, 13353 Berlin, Germany
    Ann Rheum Dis 69:34-8. 2010
    ..AS has been related to other inflammatory diseases, however, there is a paucity of data on whether AS is associated with inflammatory PD...
  77. ncbi request reprint [Pharmacotherapy of rheumatic diseases in the aged]
    S Kary
    Medizinische Klinik mit Schwerpunkt Rheumatologie und Klinische Immunologie, Universitätsklinikum Humboldt Universität Berlin
    Internist (Berl) 44:951-8. 2003
    ..The administration of these drugs in elderly patients is discussed...
  78. ncbi request reprint Association among rheumatoid arthritis, oral hygiene, and periodontitis
    N Pischon
    Department of Periodontology, Charite Medical Faculty Berlin, Augustenburger Platz 1, Berlin, Germany
    J Periodontol 79:979-86. 2008
    ..Further, it is unclear to what extent poor oral hygiene among patients with RA may account for this association...
  79. ncbi request reprint Analyses of similarities and differences in glucocorticoid therapy between rheumatoid arthritis and ankylosing spondylitis - a systematic comparison
    C M Spies
    Department of Rheumatology and Clinical Immunology, Charite University Hospital, Berlin, Germany
    Clin Exp Rheumatol 27:S152-8. 2009
    ..Translation of insights on GC action and resistance obtained in RA to AS may contribute to a better understanding of the pathophysiology of both diseases...
  80. doi request reprint [Influence of adjuvant pain medication on quality of life in the treatment of postmenopausal osteoporosis]
    D Krocker
    Klinik für Orthopädie, Centrum für Muskuloskeletale Chirurgie, Charite Universitatsmedizin Berlin, Chariteplatz 1, 10117 Berlin
    Orthopade 37:435-9. 2008
    ..The second question was if a recommendation can be formulated whether a peripheral or a central acting pain medication is more effective to prevent osteoporosis induced chronic pain...
  81. ncbi request reprint Effects of norepinephrine on oxygen consumption of quiescent and activated human peripheral blood mononuclear cells
    Jan D Lunemann
    Department of Neurology, Division of Neuroimmunology, Charite University Hospital, Berlin, Germany
    Ann N Y Acad Sci 966:365-8. 2002
  82. ncbi request reprint [Polyarteritis nodosa - a "classical" case]
    H U Scherer
    Charite Universitatsmedizin Berlin, Abteilung für Rheumatologie und klinische Immunologie, Berlin, Germany
    Z Rheumatol 65:311-4. 2006
    ..This case underlines the interdisciplinary character of the disease, challenging neurologists, dermatologists, rheumatologists and orthopedics alike...
  83. ncbi request reprint Effects of celecoxib on the expression of osteoprotegerin, energy metabolism and cell viability in cultured human osteoblastic cells
    P Kolar
    Department of Rheumatology and Clinical Immunology and Deutsches Rheumaforschungszentrum, Humboldt University, Berlin, Germany
    Clin Exp Rheumatol 27:99-107. 2009
    ..This study aimed to investigate the dose-dependent effects of celecoxib on cell viability, energy metabolism and bone remodeling processes in cultured human osteoblastic cells...
  84. ncbi request reprint Molecular mechanisms of glucocorticoid-induced osteoporosis
    D Patschan
    Department of Rheumatology and Clinical Immunology, , , Berlin, Germany
    Bone 29:498-505. 2001
    ..It is possible, but has yet to be shown, that these effects play a role in the pathogenesis of glucocorticoid-induced osteoporosis...
  85. ncbi request reprint [Current insights into the development of new glucocorticoid receptor ligands]
    F Buttgereit
    Medizinische Klinik m S Rheumatologie und Klinische Immunologie, Charite Universitatsmedizin Berlin, Schumannstr 20 21, 10117 Berlin, Germany
    Z Rheumatol 64:170-6. 2005
    ....
  86. ncbi request reprint [Prescription of glucocorticoids by rheumatologists in patients with rheumatoid arthritis in Germany]
    K Thiele
    Deutsches Rheuma ForschungsZentrum Berlin, Forschungsbereich Epidemiologie, 10117 Berlin, Germany
    Z Rheumatol 64:149-54. 2005
    ..The data emphasize the high importance of GCs in modern rheumatology...
  87. doi request reprint Morning stiffness and its influence on early retirement in patients with recent onset rheumatoid arthritis
    G Westhoff
    Epidemiology Unit, German Rheumatism Research Centre, Berlin, Germany
    Rheumatology (Oxford) 47:980-4. 2008
    ..To describe the association between morning stiffness (MS) and early retirement in patients with early RA...
  88. doi request reprint A case of Erdheim-Chester disease initially mistaken for Ormond's disease
    Konstanze Loddenkemper
    Department of Rheumatology and Clinical Immunology, Charite University Medicine, Berlin, Germany
    Nat Clin Pract Rheumatol 4:50-5. 2008
    ..Re-evaluation of the CT scans and histological biopsy samples revealed unusual sclerosis of the long bones and diffuse infiltrates of foamy histiocytes in the bone marrow and the retroperitoneum...
  89. doi request reprint Cellular composition of the initial fracture hematoma compared to a muscle hematoma: a study in sheep
    Katharina Schmidt-Bleek
    Julius Wolff Institut, Charite Universitatsmedizin Berlin, Berlin, Germany
    J Orthop Res 27:1147-51. 2009
    ..B cell percentage increased in the fracture but not in the muscle hematoma from 1 to 4 h. This is the first study that compares the immune cell subpopulations of a fracture and muscle hematoma...
  90. doi request reprint Optimized glucocorticoid therapy: teaching old drugs new tricks
    Cindy Strehl
    Department of Rheumatology and Clinical Immunology, Charite Universitatsmedizin Berlin, Campus Mitte, Berlin, Germany Electronic address
    Mol Cell Endocrinol 380:32-40. 2013
    ..Besides approaches to improve the treatment with conventional glucocorticoids currently available to clinicians, new innovative GCs or GC receptor ligands are also being developed. ..
  91. ncbi request reprint [Acute mesenteric ischemia in a patient with relapsing polychondritis]
    O Schultz
    Medizinische Klinik mit Schwerpunkt Rheumatologie und Klinische Immunologie, Universitätsklinikum Charité Berlin, Berlin
    Z Rheumatol 65:63-8. 2006
    ..The unusual presentation should be considered in the differential diagnosis of uncommon abdominal symptoms during the course of relapsing polychondritis...
  92. doi request reprint Dose-related patterns of glucocorticoid-induced side effects
    D Huscher
    German Rheumatism Research Centre Berlin, Epidemiology Unit, Berlin, Germany
    Ann Rheum Dis 68:1119-24. 2009
    ..To identify patterns of self-reported health problems relating to dose and duration of glucocorticoid intake in unselected patients with rheumatoid arthritis from routine practice...
  93. ncbi request reprint Norepinephrine inhibits energy metabolism of human peripheral blood mononuclear cells via adrenergic receptors
    J D Lünemann
    Department of Neurology, Charite University Hospital, Berlin, Germany
    Biosci Rep 21:627-35. 2001
    ..These findings have important implications for the understanding of stress-induced suppression of immune function and may contribute to the elucidation of the pathogenesis of immunologically mediated diseases...
  94. ncbi request reprint Rapid immunosuppressive effects of glucocorticoids mediated through Lck and Fyn
    Mark Lowenberg
    Laboratory of Experimental Internal Medicine, Academic Medical Center, Meibergdreef 9, NL 1105 AZ Amsterdam, The Netherlands
    Blood 106:1703-10. 2005
    ..These results identify the inhibition of Lck and Fyn kinases as rapid targets of GCs, mediated via a GC receptor-dependent pathway...
  95. ncbi request reprint Developments in glucocorticoid therapy
    Johannes W J Bijlsma
    Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Box 85500, 3508 GA Utrecht, The Netherlands
    Rheum Dis Clin North Am 31:1-17, vii. 2005
    ..One is the improvement in new GC compounds--designer GCs, alterations in bioactivity, and alterations in formulations. The other is a better understanding and management of the toxicity of GCs...
  96. doi request reprint Novel insights into mechanisms of glucocorticoid action and the development of new glucocorticoid receptor ligands
    Mark Lowenberg
    Department of Gastroenterology and Hepatology, Academic Medical Center, Meibergdreef 9, NL 1105 AZ Amsterdam, The Netherlands
    Steroids 73:1025-9. 2008
    ..As a consequence, membrane-linked GC receptors might be a potential candidate target for GC therapy. The ultimate goal is to convert these molecular insights into new GC receptor modulators with an improved therapeutic index...
  97. pmc Glucocorticoids cause rapid dissociation of a T-cell-receptor-associated protein complex containing LCK and FYN
    Mark Lowenberg
    Laboratory of Experimental Internal Medicine, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    EMBO Rep 7:1023-9. 2006
    ..These observations support a model for nongenomic GC-induced immunosuppression on the basis of dissolution of membrane-bound GC-receptor multiprotein complexes after GC-receptor ligation...
  98. ncbi request reprint Current use of glucocorticoids in patients with rheumatoid arthritis in Germany
    Katja Thiele
    German Rheumatism Research Centre, Berlin
    Arthritis Rheum 53:740-7. 2005
    ..To describe the current use of glucocorticoids in German patients with rheumatoid arthritis (RA)...
  99. doi request reprint Circadian rhythms of nocturnal hormones in rheumatoid arthritis: translation from bench to bedside
    Maurizio Cutolo
    Ann Rheum Dis 67:905-8. 2008
  100. ncbi request reprint Development of cervical interspinous bursitis after prolonged sports trauma: a case report
    Carsten Perka
    Joint Bone Spine 73:118-20. 2006
  101. ncbi request reprint Oxygen consumption and mitochondrial membrane potential indicate developmental adaptation in energy metabolism of rat cortical neurons
    Sebastian Schuchmann
    Institut für Diagnostische Radiologie und Neuroradiologie, Ernst Moritz Arndt Universitat, Friedrich Loeffler Strasse 23a, D 17487 Greifswald, Germany
    Eur J Neurosci 21:2721-32. 2005
    ....