Gerd R Burmester

Summary

Affiliation: Humboldt University
Country: Germany

Publications

  1. pmc Kitasato Symposium 2010: new prospects for cytokines
    Gerd R Burmester
    CC12, Charite Universitatsmedizin Berlin, Chariteplatz 01, 10098 Berlin, Germany
    Arthritis Res Ther 12:301. 2010
  2. pmc A randomised, double-blind, parallel-group study of the safety and efficacy of subcutaneous tocilizumab versus intravenous tocilizumab in combination with traditional disease-modifying antirheumatic drugs in patients with moderate to severe rheumatoid art
    Gerd R Burmester
    Charite Universitatsmedizin Berlin, Free University and Humboldt University of Berlin, Berlin, Germany
    Ann Rheum Dis 73:69-74. 2014
  3. pmc Efficacy and safety of mavrilimumab in subjects with rheumatoid arthritis
    Gerd R Burmester
    Charite University Medicine Berlin, Department of Rheumatology and Clinical Immunology Free University and Humboldt University, Berlin, Germany
    Ann Rheum Dis 72:1445-52. 2013
  4. pmc Adalimumab: long-term safety in 23 458 patients from global clinical trials in rheumatoid arthritis, juvenile idiopathic arthritis, ankylosing spondylitis, psoriatic arthritis, psoriasis and Crohn's disease
    Gerd R Burmester
    Correspondence to Professor G R Burmester, Department of Rheumatology and Clinical Immunology, Charite University Medicine Berlin, Chariteplatz 1, 10117 Berlin, Germany
    Ann Rheum Dis 72:517-24. 2013
  5. doi request reprint Tofacitinib (CP-690,550) in combination with methotrexate in patients with active rheumatoid arthritis with an inadequate response to tumour necrosis factor inhibitors: a randomised phase 3 trial
    Gerd R Burmester
    Charite University Medicine Berlin, Berlin, Germany
    Lancet 381:451-60. 2013
  6. pmc Inflammation assessment in patients with arthritis using a novel in vivo fluorescence optical imaging technology
    Stephanie G Werner
    Rheumatology, Immunology, Osteology Center, Duesseldorf, Germany
    Ann Rheum Dis 71:504-10. 2012
  7. doi request reprint RA in 2011: Advances in diagnosis, treatment and definition of remission
    Gerd R Burmester
    Department of Rheumatology and Clinical Immunology, Charite Universitatsmedizin Berlin, Chariteplatz 1, 10117 Berlin, Germany
    Nat Rev Rheumatol 8:65-6. 2012
  8. pmc Anti-dsDNA-NcX ELISA: dsDNA-loaded nucleosomes improve diagnosis and monitoring of disease activity in systemic lupus erythematosus
    Robert Biesen
    Department of Rheumatology and Clinical Immunology, Charite Universitatsmedizin Berlin, Chariteplatz 1, Berlin D 10117, Germany
    Arthritis Res Ther 13:R26. 2011
  9. pmc Diagnostic value and clinical laboratory associations of antibodies against recombinant ribosomal P0, P1 and P2 proteins and their native heterocomplex in a Caucasian cohort with systemic lupus erythematosus
    Fidan Barkhudarova
    Department of Rheumatology and Clinical Immunology, Charite Universitatsmedizin Berlin, Chariteplatz 1, Berlin D 10117, Germany
    Arthritis Res Ther 13:R20. 2011
  10. pmc Single-step autoantibody profiling in antiphospholipid syndrome using a multi-line dot assay
    Karl Egerer
    Department of Rheumatology and Clinical Immunology, Charite Universitatsmedizin Berlin, Chariteplatz 1, 10117 Berlin, Augustenburger Platz 01, 13555 Berlin, Germany
    Arthritis Res Ther 13:R118. 2011

Detail Information

Publications167 found, 100 shown here

  1. pmc Kitasato Symposium 2010: new prospects for cytokines
    Gerd R Burmester
    CC12, Charite Universitatsmedizin Berlin, Chariteplatz 01, 10098 Berlin, Germany
    Arthritis Res Ther 12:301. 2010
    ..The presentations at the Symposium resulted in productive discussions regarding potential new targets for the treatment of rheumatoid arthritis and other autoimmune disorders...
  2. pmc A randomised, double-blind, parallel-group study of the safety and efficacy of subcutaneous tocilizumab versus intravenous tocilizumab in combination with traditional disease-modifying antirheumatic drugs in patients with moderate to severe rheumatoid art
    Gerd R Burmester
    Charite Universitatsmedizin Berlin, Free University and Humboldt University of Berlin, Berlin, Germany
    Ann Rheum Dis 73:69-74. 2014
    ..This study compared the efficacy and safety of subcutaneous (SC) versus intravenous (IV) formulations of tocilizumab in patients with rheumatoid arthritis with an inadequate response to disease-modifying antirheumatic drugs (DMARD)...
  3. pmc Efficacy and safety of mavrilimumab in subjects with rheumatoid arthritis
    Gerd R Burmester
    Charite University Medicine Berlin, Department of Rheumatology and Clinical Immunology Free University and Humboldt University, Berlin, Germany
    Ann Rheum Dis 72:1445-52. 2013
    ....
  4. pmc Adalimumab: long-term safety in 23 458 patients from global clinical trials in rheumatoid arthritis, juvenile idiopathic arthritis, ankylosing spondylitis, psoriatic arthritis, psoriasis and Crohn's disease
    Gerd R Burmester
    Correspondence to Professor G R Burmester, Department of Rheumatology and Clinical Immunology, Charite University Medicine Berlin, Chariteplatz 1, 10117 Berlin, Germany
    Ann Rheum Dis 72:517-24. 2013
    ..Registry safety data in rheumatoid arthritis (RA) are available, but these patients may not be monitored as closely as patients in a clinical trial. Cross-indication safety reviews of available anti-TNF agents are limited...
  5. doi request reprint Tofacitinib (CP-690,550) in combination with methotrexate in patients with active rheumatoid arthritis with an inadequate response to tumour necrosis factor inhibitors: a randomised phase 3 trial
    Gerd R Burmester
    Charite University Medicine Berlin, Berlin, Germany
    Lancet 381:451-60. 2013
    ..We investigated the effectiveness of tofacitinib (CP-690,550), a novel oral Janus kinase inhibitor, as a targeted immunomodulator and disease-modifying therapy for rheumatoid arthritis...
  6. pmc Inflammation assessment in patients with arthritis using a novel in vivo fluorescence optical imaging technology
    Stephanie G Werner
    Rheumatology, Immunology, Osteology Center, Duesseldorf, Germany
    Ann Rheum Dis 71:504-10. 2012
    ..In experimental models of arthritis, FOI findings corresponded to histologically proven synovitis. This is the first comparative study of FOI with other imaging modalities in humans with arthritis...
  7. doi request reprint RA in 2011: Advances in diagnosis, treatment and definition of remission
    Gerd R Burmester
    Department of Rheumatology and Clinical Immunology, Charite Universitatsmedizin Berlin, Chariteplatz 1, 10117 Berlin, Germany
    Nat Rev Rheumatol 8:65-6. 2012
    ..Together with new definitions of remission, these advances could aid the development of personalized, treat-to-target strategies...
  8. pmc Anti-dsDNA-NcX ELISA: dsDNA-loaded nucleosomes improve diagnosis and monitoring of disease activity in systemic lupus erythematosus
    Robert Biesen
    Department of Rheumatology and Clinical Immunology, Charite Universitatsmedizin Berlin, Chariteplatz 1, Berlin D 10117, Germany
    Arthritis Res Ther 13:R26. 2011
    ....
  9. pmc Diagnostic value and clinical laboratory associations of antibodies against recombinant ribosomal P0, P1 and P2 proteins and their native heterocomplex in a Caucasian cohort with systemic lupus erythematosus
    Fidan Barkhudarova
    Department of Rheumatology and Clinical Immunology, Charite Universitatsmedizin Berlin, Chariteplatz 1, Berlin D 10117, Germany
    Arthritis Res Ther 13:R20. 2011
    ..In this study, we sought to determine the diagnostic value and clinical laboratory associations of autoantibodies against recombinant ribosomal P0, P1 and P2 proteins and their native heterocomplex in systemic lupus erythematosus (SLE)...
  10. pmc Single-step autoantibody profiling in antiphospholipid syndrome using a multi-line dot assay
    Karl Egerer
    Department of Rheumatology and Clinical Immunology, Charite Universitatsmedizin Berlin, Chariteplatz 1, 10117 Berlin, Augustenburger Platz 01, 13555 Berlin, Germany
    Arthritis Res Ther 13:R118. 2011
    ..Diagnosis of antiphospholipid syndrome (APS) still remains a laboratory challenge due to the great diversity of antiphospholipid antibodies (aPL) and their significance regarding APS-diagnostic criteria...
  11. pmc Safety and clinical outcomes of rituximab therapy in patients with different autoimmune diseases: experience from a national registry (GRAID)
    Hans Peter Tony
    Medizinische Klinik und Poliklinik II, Universitatsklinikum Wurzburg, Klinikstr 6 8, 97070 Wurzburg, Germany
    Arthritis Res Ther 13:R75. 2011
    ....
  12. pmc The association between rheumatoid arthritis and periodontal disease
    Jacqueline Detert
    Department of Rheumatology and Clinical Immunology, Charite Universitatsmedizin Berlin, Campus Mitte, Chariteplatz 1, 10117 Berlin, Germany
    Arthritis Res Ther 12:218. 2010
    ....
  13. pmc Biomarkers as tools for improved diagnostic and therapeutic monitoring in systemic lupus erythematosis
    Michael F Smith
    Wyeth Research, Discovery Translational Medicine, Collegeville, PA 19426, USA
    Arthritis Res Ther 11:255. 2009
    ....
  14. pmc Rapid and sustained improvements in health-related quality of life, fatigue, and other patient-reported outcomes in rheumatoid arthritis patients treated with certolizumab pegol plus methotrexate over 1 year: results from the RAPID 1 randomized controlled
    Vibeke Strand
    Division of Immunology Rheumatology, Stanford University School of Medicine, 306 Ramona Road, Palo Alto, CA, 94028, USA
    Arthritis Res Ther 11:R170. 2009
    ..The objective of this study was to assess the impact of certolizumab pegol (CZP) treatment on health-related quality of life (HRQoL), fatigue and other patient-reported outcomes (PROs) in patients with rheumatoid arthritis (RA)...
  15. pmc The human anti-IL-1 beta monoclonal antibody ACZ885 is effective in joint inflammation models in mice and in a proof-of-concept study in patients with rheumatoid arthritis
    Rieke Alten
    Department of Internal Medicine II, Rheumatology, Schlosspark Klinik Teaching Hospital Charité University Medicine Berlin, Heubnerweg, D 14059 Berlin, Germany
    Arthritis Res Ther 10:R67. 2008
    ..IL-1beta is a proinflammatory cytokine driving joint inflammation as well as systemic signs of inflammation, such as fever and acute phase protein production...
  16. pmc Automated evaluation of autoantibodies on human epithelial-2 cells as an approach to standardize cell-based immunofluorescence tests
    Karl Egerer
    Department of Rheumatology and Clinical Immunology, Charite Universitatsmedizin Berlin, Chariteplatz 1, 10117 Berlin, Germany
    Arthritis Res Ther 12:R40. 2010
    ..Comparing automated and visual interpretation, the usefulness for routine laboratory diagnostics was investigated...
  17. pmc Differential expression of chemokine receptors on peripheral blood B cells from patients with rheumatoid arthritis and systemic lupus erythematosus
    Maren Henneken
    Deutsches Rheuma ForschungsZentrum, Berlin, Germany
    Arthritis Res Ther 7:R1001-13. 2005
    ..However, differences between patients with RA and patients with SLE point toward a disease-specific regulation of receptor expression. These differences may influence the migrational behavior of B cells...
  18. pmc Cells of the synovium in rheumatoid arthritis. Macrophages
    Raimund W Kinne
    Experimental Rheumatology Unit, Department of Orthopedics, University Clinic, Jena, Klosterlausnitzer Str, 81, D 07607 Eisenberg, Germany
    Arthritis Res Ther 9:224. 2007
    ..This approach has two advantages: (a) striking the cell population that mediates/amplifies most of the irreversible tissue destruction and (b) sparing other cells that have no (or only marginal) effects on joint damage...
  19. pmc Clinical and functional remission: even though biologics are superior to conventional DMARDs overall success rates remain low--results from RABBIT, the German biologics register
    Joachim Listing
    German Rheumatism Research Centre, Berlin, Germany
    Arthritis Res Ther 8:R66. 2006
    ..However, temporary or even sustained remission remain ambitious aims, which are achieved in a minority of patients only...
  20. pmc Cardiovascular disease in patients with rheumatoid arthritis: results from the QUEST-RA study
    Antonio Naranjo
    Hospital de Gran Canaria Dr, Negrin, University of Las Palmas de Gran Canaria, Barranco de la Ballena s n 35011, Spain
    Arthritis Res Ther 10:R30. 2008
    ....
  21. pmc Treatment of posttraumatic and focal osteoarthritic cartilage defects of the knee with autologous polymer-based three-dimensional chondrocyte grafts: 2-year clinical results
    Christian Ossendorf
    Department of Traumotology and Orthopaedic Surgery, University of Freiburg, Hugstetter Strasse 55, 79106 Freiburg, Germany
    Arthritis Res Ther 9:R41. 2007
    ..The results suggest that implanting BioSeed-C is an effective treatment option for the regeneration of posttraumatic and/or osteoarthritic defects of the knee...
  22. pmc Epratuzumab (humanised anti-CD22 antibody) in primary Sjögren's syndrome: an open-label phase I/II study
    Serge D Steinfeld
    Department of Rheumatology, Erasme University Hospital, 808 Route de Lennik, Brussels 1070, Belgium
    Arthritis Res Ther 8:R129. 2006
    ..Thus, epratuzumab appears to be a promising therapy in active pSS, suggesting that further studies be conducted...
  23. pmc Risk of incident or recurrent malignancies among patients with rheumatoid arthritis exposed to biologic therapy in the German biologics register RABBIT
    Anja Strangfeld
    German Rheumatism Research Centre Berlin, a Leibniz Institute, Chariteplatz 1, 10117 Berlin, Germany
    Arthritis Res Ther 12:R5. 2010
    ....
  24. pmc Decrease in expression of bone morphogenetic proteins 4 and 5 in synovial tissue of patients with osteoarthritis and rheumatoid arthritis
    Carsten P Bramlage
    Department of Medicine, Nephrology and Rheumatology, Georg August University Gottingen, Robert Koch Strasse 40, D 37075 Gottingen, Germany
    Arthritis Res Ther 8:R58. 2006
    ..In comparison with previous reports, these data underline the complex impact of these factors on homeostasis and remodeling in joint physiology and pathology...
  25. pmc The appropriate use of non-steroidal anti-inflammatory drugs in rheumatic disease: opinions of a multidisciplinary European expert panel
    Gerd Burmester
    Department of Rheumatology and Clinical Immunology, Charite University Medicine, Free University and Humboldt University Berlin, Charitéplatz 1 10117, Berlin, Germany
    Ann Rheum Dis 70:818-22. 2011
    ....
  26. pmc Effectiveness and safety of the interleukin 6-receptor antagonist tocilizumab after 4 and 24 weeks in patients with active rheumatoid arthritis: the first phase IIIb real-life study (TAMARA)
    Gerd R Burmester
    Charite Universitatsmedizin Berlin, Department of Rheumatology and Clinical Immunology, Free University and Humboldt University of Berlin, Chariteplatz 1, 10117 Berlin, Germany
    Ann Rheum Dis 70:755-9. 2011
    ..To confirm the effectiveness and safety of the interleukin 6-receptor antagonist tocilizumab in patients with rheumatoid arthritis (RA) in a setting close to real-life medical care in Germany...
  27. doi request reprint Clinical remission and/or minimal disease activity in patients receiving adalimumab treatment in a multinational, open-label, twelve-week study
    Gerd R Burmester
    Charite University Medicine Berlin, Berlin, Germany
    Arthritis Rheum 59:32-41. 2008
    ....
  28. pmc Kitasato symposium 2009: new prospects for cytokine inhibition
    Gerd R Burmester
    CC12, Charite Universitatsmedizin Berlin, Chariteplatz 01, 10098 Berlin, Germany
    Arthritis Res Ther 11:301. 2009
    ..The involvement of cytokines in other autoimmune diseases was also addressed...
  29. doi request reprint Canakinumab for treatment of cryopyrin-associated periodic syndrome
    Eugen Feist
    Department of Rheumatology and Clinical Immunology, Charite Universitatsmedizin Berlin, Chariteplatz 1, D 10117 Berlin, Germany
    Expert Opin Biol Ther 10:1631-6. 2010
    ..The inflammatory response in CAPS is caused by an overwhelming activation of the pro-inflammatory cytokine IL-1, which was identified as a promising treatment target...
  30. pmc Adalimumab alone and in combination with disease-modifying antirheumatic drugs for the treatment of rheumatoid arthritis in clinical practice: the Research in Active Rheumatoid Arthritis (ReAct) trial
    Gerd R Burmester
    Department of Rheumatology and Clinical Immunology, Charite University Medicine Berlin, Chariteplatz 1, 10117 Berlin, Germany
    Ann Rheum Dis 66:732-9. 2007
    ..To evaluate the safety and effectiveness of adalimumab alone or in combination with standard disease-modifying antirheumatic drugs (DMARDs) for the treatment of rheumatoid arthritis (RA)...
  31. ncbi request reprint [Revision of the recommendations of the Commission on Pharmacotherapy of the German Society for Rheumatology. Comment on the use of Orthokin]
    G R Burmester
    Medizinische Klinik mit Schwerpunkt Rheumatologie und Klinische Immunologie, Charite Universitatsmedizin Berlin
    Z Rheumatol 66:83-4. 2007
    ..Until these data have been published in an appropriate specialist journal, it is not possible for the DGRh to give a recommendation...
  32. pmc The needle and the damage done
    J K Franz
    Department of Rheumatology and Clinical Immunology, Charite University Hospital, Humboldt University of Berlin, Schumannstr 20 21, D 10098 Berlin, Germany
    Ann Rheum Dis 64:798-800. 2005
  33. pmc Adalimumab safety and mortality rates from global clinical trials of six immune-mediated inflammatory diseases
    G R Burmester
    Charite University Medicine Berlin, Free University and Humboldt University of Berlin, 10117 Berlin, Germany
    Ann Rheum Dis 68:1863-9. 2009
    ..To assess the safety of adalimumab in rheumatoid arthritis (RA) over time and across five other immune-mediated inflammatory diseases and to compare adalimumab malignancy and mortality rates with data on the general population...
  34. ncbi request reprint Strategies using functional genomics in rheumatic diseases
    Gerd R Burmester
    Department of Rheumatology and Clinical Immunology, Charite University Medicine Berlin, Humboldt University and Free University of Berlin, Schumannstr 20 21, 10098 Berlin, Germany
    Autoimmun Rev 3:541-9. 2004
    ....
  35. pmc Mavrilimumab, a human monoclonal antibody targeting GM-CSF receptor-α, in subjects with rheumatoid arthritis: a randomised, double-blind, placebo-controlled, phase I, first-in-human study
    Gerd R Burmester
    Department of Rheumatology and Clinical Immunology, Charite University Medicine Berlin, Berlin, Germany
    Ann Rheum Dis 70:1542-9. 2011
    ....
  36. ncbi request reprint Circulating proteasomes are markers of cell damage and immunologic activity in autoimmune diseases
    Karl Egerer
    Department of Rheumatology and Clinical Immunology, Institute of Biochemistry, Humboldt University of Berlin, Berlin, Germany
    J Rheumatol 29:2045-52. 2002
    ....
  37. doi request reprint Indocyanine green-enhanced fluorescence optical imaging in patients with early and very early arthritis: a comparative study with magnetic resonance imaging
    Stephanie G Werner
    Charite University Medicine Berlin, Berlin, Germany RHIO Center Dusseldorf and RHIO Research Institute, Dusseldorf, Germany
    Arthritis Rheum 65:3036-44. 2013
    ..We undertook this study to compare FOI with magnetic resonance imaging (MRI) in 32 patients with early and very early untreated arthritis (mean disease duration 7.1 months)...
  38. ncbi request reprint Activated memory B cell subsets correlate with disease activity in systemic lupus erythematosus: delineation by expression of CD27, IgD, and CD95
    Annett M Jacobi
    Charite Universitatsmedizin Berlin, Berlin, Germany
    Arthritis Rheum 58:1762-73. 2008
    ..Focusing on CD27- B cells, this study aimed to identify abnormalities in peripheral B cell subsets in patients with SLE...
  39. pmc Diagnostic value of anti-topoisomerase I antibodies in a large monocentric cohort
    Katharina Hanke
    Department of Rheumatology and Clinical Immunology, Charite Universitatsmedizin Berlin, Chariteplatz 1, Berlin 10117, Germany
    Arthritis Res Ther 11:R28. 2009
    ..In the present study, the detection of anti-topoisomerase I (anti-topo I) autoantibodies was evaluated for diagnosis and risk assessment of systemic sclerosis (SSc) patients in a well characterized large monocentric cohort...
  40. doi request reprint The multifaceted balance of TNF-α and type I/II interferon responses in SLE and RA: how monocytes manage the impact of cytokines
    Biljana Smiljanovic
    Deutsches Rheuma Forschungszentrum Berlin DRFZ, ein Leibniz Institut, Chariteplatz 1, 10117 Berlin, Germany
    J Mol Med (Berl) 90:1295-309. 2012
    ..The results suggest that an assessment of cytokine-response status in monocytes may be helpful for improvement of diagnosis and selection of the best cytokine target for therapeutic intervention...
  41. doi request reprint Bone marrow of NZB/W mice is the major site for plasma cells resistant to dexamethasone and cyclophosphamide: implications for the treatment of autoimmunity
    Imtiaz M Mumtaz
    Department of Rheumatology and Clinical Immunology, Charite University Hospital, Berlin, Germany
    J Autoimmun 39:180-8. 2012
    ..Therefore, new strategies targeting autoreactive plasma cell memory should be considered. This could be the key to finding a curative approach to the treatment of chronic inflammatory autoantibody-mediated diseases...
  42. ncbi request reprint Correlation between circulating CD27high plasma cells and disease activity in patients with systemic lupus erythematosus
    Annett M Jacobi
    University Hospital Charite, Berlin, Germany
    Arthritis Rheum 48:1332-42. 2003
    ..In order to determine whether SLE disease activity correlates with abnormal B lymphocyte activity, B cell subsets were analyzed, and their relationship to clinical and humoral measures of disease activity was assessed...
  43. ncbi request reprint Circulating levels of matrix metalloproteinases MMP-3 and MMP-1, tissue inhibitor of metalloproteinases 1 (TIMP-1), and MMP-1/TIMP-1 complex in rheumatic disease. Correlation with clinical activity of rheumatoid arthritis versus other surrogate markers
    G Keyszer
    Department of Rheumatology and Clinical Immunology, Charite University Hospital, Berlin Buch, Berlin, Germany
    J Rheumatol 26:251-8. 1999
    ....
  44. doi request reprint Defining TNF-α- and LPS-induced gene signatures in monocytes to unravel the complexity of peripheral blood transcriptomes in health and disease
    Biljana Smiljanovic
    Deutsches Rheuma Forschungszentrum Berlin DRFZ, a Leibniz Institute, Chariteplatz 1, 10117, Berlin, Germany
    J Mol Med (Berl) 88:1065-79. 2010
    ....
  45. ncbi request reprint Gene expression profiling of rheumatoid arthritis synovial cells treated with antirheumatic drugs
    Thomas Häupl
    Tissue Engineering Laboratory, Department of Rheumatology, Charite Universitatsmedizin Berlin, Campus Mitte, Tucholskystrasse 2, 10117 Berlin, Germany
    J Biomol Screen 12:328-40. 2007
    ..Synovial fibroblasts reflect the disease-related pathophysiology and are useful tools for screening putative antirheumatic compounds...
  46. doi request reprint Small molecules targeting JAKs--a new approach in the treatment of rheumatoid arthritis
    Eugen Feist
    Department of Rheumatology and Clinical Immunology, Charite Universitatsmedizin Berlin, Free University and Humboldt University of Berlin, Chariteplatz 1, D 10117 Berlin, Germany
    Rheumatology (Oxford) 52:1352-7. 2013
    ..This review focuses on the development of new small molecule inhibitors of Janus kinases in clinical trials in RA. ..
  47. ncbi request reprint Tissue-specific up-regulation of the proteasome subunit beta5i (LMP7) in Sjögren's syndrome
    Thomas Egerer
    Charite Universitatsmedizin Berlin, Humboldt University of Berlin, Berlin, Germany
    Arthritis Rheum 54:1501-8. 2006
    ..Since these histologic findings are nonspecific, determination of clinical and serologic abnormalities contribute to the diagnosis. The aim of this study was to identify a novel, disease-specific, immunologically relevant marker for SS...
  48. doi request reprint Splenic proliferative lymphoid nodules distinct from germinal centers are sites of autoantigen stimulation in immune thrombocytopenia
    Capucine Daridon
    CC12 Department of Medicine, Rheumatology and Clinical Immunology, Charite University Medicine Berlin, Berlin, Germany
    Blood 120:5021-31. 2012
    ..Autoantigens were not found in the GCs of ITP or controls indicating that PLNs are the sites of autoantigen stimulation in ITP potentially related to a lack of control by T cells and/or the present autoantigen...
  49. pmc Bronchoalveoloar lavage fluid cytokines and chemokines as markers and predictors for the outcome of interstitial lung disease in systemic sclerosis patients
    Katrin Schmidt
    Department of Rheumatology and Clinical Immunology, Charite Universitatsmedizin Berlin, Chariteplatz 1, Berlin, Germany
    Arthritis Res Ther 11:R111. 2009
    ..The aim of the current study was to identify specific changes in cytokine levels that may serve as disease markers and possible targets for therapy...
  50. ncbi request reprint B-cell-directed therapies for autoimmune disease
    Thomas Dorner
    Charite Center 12 and 14, Charité University Hospital and Deutsches Rheuma Forschungszentrum Berlin, Berlin, Germany
    Nat Rev Rheumatol 5:433-41. 2009
    ....
  51. doi request reprint Anticytokine therapy impacting on B cells in autoimmune diseases
    Capucine Daridon
    Department of Rheumatology and Clinical Immunology, Charité University Medicine Berlin and Deutsches, Rheumaforschungszentrum, Berlin 10098, Germany
    Curr Opin Rheumatol 21:205-10. 2009
    ....
  52. doi request reprint Expression of proteasomal immunosubunit beta1i is dysregulated in inflammatory infiltrates of minor salivary glands in Sjogren's syndrome
    Lars Morawietz
    Department of Rheumatology and Clinical Immunology, Institute of Pathology, and Institute of Biochemistry, Charite Universitatsmedizin Berlin, Free University and Humboldt University of Berlin, Berlin, Germany
    J Rheumatol 36:2694-703. 2009
    ..Minor salivary gland specimens were analyzed to investigate dysregulation of the proteasome system in patients with Sjögren's syndrome (SS) and patients with sicca syndrome...
  53. ncbi request reprint The systemic and SmD183-119-autoantigen-specific cytokine memory of Th cells in SLE patients
    S Langer
    Department of Rheumatology and Clinical Immunology, Charite University Hospital, Schumannstr 20 21, D 10117 Berlin, Germany
    Rheumatology (Oxford) 46:238-45. 2007
    ....
  54. doi request reprint Induction therapy with adalimumab plus methotrexate for 24 weeks followed by methotrexate monotherapy up to week 48 versus methotrexate therapy alone for DMARD-naive patients with early rheumatoid arthritis: HIT HARD, an investigator-initiated study
    Jacqueline Detert
    Department of Rheumatology and Clinical Immunology, Charite Universitatsmedizin Berlin, Berlin, Germany
    Ann Rheum Dis 72:844-50. 2013
    ..To investigate the long-term effects of induction therapy with adalimumab (ADA) plus methotrexate (MTX) in comparison with placebo (PBO) plus MTX in DMARD-naïve patients with active early rheumatoid arthritis (RA)...
  55. doi request reprint Urinary CD4 T cells identify SLE patients with proliferative lupus nephritis and can be used to monitor treatment response
    Philipp Enghard
    Department of Nephrology and Intensive Care Medicine, Charite Universitatsmedizin Berlin, Berlin, Germany
    Ann Rheum Dis 73:277-83. 2014
    ..Proliferative lupus nephritis (LN) is one of the major concerns in the treatment of systemic lupus erythematosus (SLE). Here we evaluate urinary CD4 T cells as a biomarker of active LN and indicator of treatment response...
  56. doi request reprint A1.18 From tissue- and cell-specific transcriptomes to candidate markers in rheumatoid arthritis
    Biljana Smiljanovic
    Department of Rheumatology and Clinical Immunology, Charité CCM, Chariteplatz 1, 10117 Berlin, Germany
    Ann Rheum Dis 73:A7-8. 2014
    ..Based on transcriptome data candidate markers were selected and validated at the protein level...
  57. doi request reprint Gene expression of catalytic proteasome subunits and resistance toward proteasome inhibition of B lymphocytes from patients with primary sjogren syndrome
    Lorena Martinez-Gamboa
    Rheumatology Research Laboratory, Department of Rheumatology and Clinical Immunology, Charite Universitatsmedizin Berlin, Germany
    J Rheumatol 40:663-73. 2013
    ..Dysregulation of proteasome subunit β1i expression has been shown in total blood mononuclear cells (PBMC) from patients with primary Sjögren syndrome (pSS), a B cell-driven systemic autoimmune disorder...
  58. ncbi request reprint Bone morphogenetic proteins promote cartilage differentiation and protect engineered artificial cartilage from fibroblast invasion and destruction
    Christian Kaps
    Charite University Hospital, Humboldt University of Berlin, Germany
    Arthritis Rheum 46:149-62. 2002
    ..Therefore, this study was undertaken to investigate the potential of bone morphogenetic proteins (BMPs) in chondrocyte differentiation using current technologies of tissue engineering...
  59. ncbi request reprint Casein is an essential cofactor in autoantibody reactivity directed against the C-terminal SmD1 peptide AA 83-119 in systemic lupus erythematosus
    Gabriela Riemekasten
    Department of Rheumatology and Clinical Immunology, Charite University Hospital, Berlin, Germany
    Immunobiology 206:537-45. 2002
    ..In conclusion, casein seems to be an important cofactor in autoantibody reactivity directed against the C-terminal SmD1(83-119) peptide and probably functions by changing the conformation of the peptide's critical epitope...
  60. ncbi request reprint Diminished peripheral blood memory B cells and accumulation of memory B cells in the salivary glands of patients with Sjögren's syndrome
    Arne Hansen
    University Hospital Charite, Berlin, Germany
    Arthritis Rheum 46:2160-71. 2002
    ..To delineate the mechanism of the abnormalities in B cell biology found in patients with primary Sjögren's syndrome (SS)...
  61. pmc Immediate determination of ACPA and rheumatoid factor--a novel point of care test for detection of anti-MCV antibodies and rheumatoid factor using a lateral-flow immunoassay
    Franziska Renger
    Department of Rheumatology and Clinical Immunology, Charite Universitatsmedizin Berlin, Chariteplatz 1, 10117 Berlin, Germany
    Arthritis Res Ther 12:R120. 2010
    ..The aim of this study was to develop and evaluate a point of care test (POCT) for detection of anti-MCV antibodies immediately at the first visit or at the bed side...
  62. pmc SiPaGene: A new repository for instant online retrieval, sharing and meta-analyses of GeneChip expression data
    Adriane Menssen
    Department of Rheumatology and Clinical Immunology, Charite University Hospital, Chariteplatz 1, Berlin, Germany
    BMC Genomics 10:98. 2009
    ..Furthermore, most of the currently existing tools do not use the whole range of statistical power provided by the MAS5.0/GCOS algorithms...
  63. doi request reprint Patient-tailored therapy in rheumatoid arthritis: an editorial review
    Hans U Scherer
    Department of Rheumatology and Clinical Immunology, Charite University Medicine Berlin, Germany
    Curr Opin Rheumatol 22:237-45. 2010
    ..Such personalized, patient-tailored therapy is still not a reality in rheumatology practice. However, several important steps have recently been made towards achievement of this important goal...
  64. ncbi request reprint Prevalence of 20S proteasome, anti-nuclear and thyroid antibodies in young patients at onset of type 1 diabetes mellitus and the risk of autoimmune thyroiditis
    Olga Kordonouri
    Clinics of General Pediatrics, Otto Heubner Centrum für Kinder und Jugendmedizin Charité, Berlin, Germany
    J Pediatr Endocrinol Metab 17:975-81. 2004
    ..In particular, patients with positive thyroid and anti-nuclear antibodies are at high risk to develop autoimmune thyroiditis during the first 5 years of DM1...
  65. ncbi request reprint [B-cell depletion in the treatment of rheumatoid arthritis]
    Eugen Feist
    Medizinische Klinik mit Schwerpunkt Rheumatologie und Klinische Immunologie, Universitätsklinikum Charité Humboldt Universität zu Berlin, Berlin, Germany
    Z Rheumatol 62:361-6. 2003
    ..Here, we discuss recent data of a temporary B cell depletion using a monoclonal anti-CD20 antibody in the therapeutic arsenal of rheumatoid arthritis...
  66. pmc The anti-CD74 humanized monoclonal antibody, milatuzumab, which targets the invariant chain of MHC II complexes, alters B-cell proliferation, migration, and adhesion molecule expression
    Daniela Frölich
    Department of Medicine, Rheumatology and Clinical Immunology, Charite University Medicine Berlin, Chariteplatz 1, Berlin 10117, Germany
    Arthritis Res Ther 14:R54. 2012
    ..Therefore, the current study addressed the influence of milatuzumab on B-cell proliferation, chemo-attractant migration, and adhesion molecule expression...
  67. ncbi request reprint The role of B cells in rheumatoid arthritis: mechanisms and therapeutic targets
    Thomas Dorner
    Department of Rheumatology and Clinical Immunology, Charite University Hospital, Berlin, Germany
    Curr Opin Rheumatol 15:246-52. 2003
    ..This review will focus on recent findings of the role of B cells in rheumatoid arthritis and the implications to target B cells in this disease...
  68. ncbi request reprint Intravenous injection of a D1 protein of the Smith proteins postpones murine lupus and induces type 1 regulatory T cells
    Gabriela Riemekasten
    Department of Rheumatology and Clinical Immunology, Charite University Hospital, Berlin, Germany
    J Immunol 173:5835-42. 2004
    ..In conclusion, these results indicate that SmD1 83-119 peptide may play a dominant role in the activation of helper and regulatory T cells that influence autoantibody generation and murine lupus...
  69. doi request reprint Anticentromere-A and anticentromere-B antibodies show high concordance and similar clinical associations in patients with systemic sclerosis
    Katharina Hanke
    Department of Rheumatology and Clinical Immunology, Charite University Medicine, Berlin, Germany
    J Rheumatol 37:2548-52. 2010
    ..To determine the diagnostic sensitivity and specificity and the clinical usefulness of parallel anticentromere-A and anticentromere-B antibody (anti-CENP-A and anti-CENP-B) testing in patients with systemic sclerosis (SSc)...
  70. doi request reprint Reactivation of rheumatoid arthritis after pregnancy: increased phagocyte and recurring lymphocyte gene activity
    Thomas Häupl
    Department of Rheumatology and Clinical Immunology, Charite University Medicine, Berlin, Germany
    Arthritis Rheum 58:2981-92. 2008
    ..This study was undertaken to generate a systematic overview of the molecular mechanisms related to disease remission and postpartum reactivation...
  71. pmc Hypoxia inducible factor (HIF) in rheumatology: low O2! See what HIF can do!
    T Gaber
    Department of Rheumatology and Clinical Immunology, Charite University Hospital, Schumannstrasse 20 21, 10117 Berlin, Germany
    Ann Rheum Dis 64:971-80. 2005
    ....
  72. doi request reprint Autoimmune reactivity against the 20S-proteasome includes immunosubunits LMP2 (beta1i), MECL1 (beta2i) and LMP7 (beta5i)
    S Scheffler
    Department of Medicine Rheumatology and Clinical Immunology, Charite Universitatsmedizin Berlin, Chariteplatz 1, D 10117 Berlin, Germany
    Rheumatology (Oxford) 47:622-6. 2008
    ..Although their pathogenic and diagnostic significance remains obscure, an involvement in the clearance of circulating proteasomes as well as an interaction with the activity of the proteolytic complex was assumed in previous studies...
  73. ncbi request reprint Modulation of intracellular calcium signaling and mitochondrial function in cultured osteoblastic cells by dexamethasone and celecoxib during mechanical stimulation
    S Schuchmann
    Medizinische Klinik mit Schwerpunkt Rheumatologie und Klinische Immunologie, Universitatsklinikum Charite, Humboldt Universitat Berlin, Germany
    Clin Exp Rheumatol 22:184-96. 2004
    ..Evaluation of potentially therapeutically relevant effects of dexamethasone and celecoxib on crucial parameters of bone physiology during and following mechanical stimulation in cultured osteoblasts...
  74. pmc Detection of oncofetal h19 RNA in rheumatoid arthritis synovial tissue
    Bruno Stuhlmuller
    Department of Internal Medicine, Rheumatology and Clinical Immunology, Charite University Hospital, Humboldt University of Berlin, Tucholskystrasse 2, D 10117 Berlin, Germany
    Am J Pathol 163:901-11. 2003
    ....
  75. doi request reprint Regenerative medicine in rheumatic disease-progress in tissue engineering
    Jochen Ringe
    Tissue Engineering Laboratory and Berlin Brandenburg Center for Regenerative Therapies, Department of Rheumatology and Clinical Immunology, Charite Universitatsmedizin Berlin, Chariteplatz 1, 10117 Berlin, Germany
    Nat Rev Rheumatol 8:493-8. 2012
    ..Tissue engineering faces a crucial phase to translate products into clinical routine and the regulatory framework for cell-based products in particular is an important issue...
  76. pmc Detailed analysis of the variability of peptidylarginine deiminase type 4 in German patients with rheumatoid arthritis: a case-control study
    Berthold Hoppe
    Institute of Transfusion Medicine, Campus Virchow Klinikum, Charite Universitatsmedizin Berlin, Germany
    Arthritis Res Ther 8:R34. 2006
    ..Quantitative or qualitative differences in previously undefined PADI4 variants between patients and controls could not be demonstrated...
  77. doi request reprint Evaluation of a novel 7-joint ultrasound score in daily rheumatologic practice: a pilot project
    M Backhaus
    Charite University Medicine Berlin, Chariteplatz 1, D 10117 Berlin, Germany
    Arthritis Rheum 61:1194-201. 2009
    ..To introduce a new standardized ultrasound score based on 7 joints of the clinically dominant hand and foot (German US7 score) implemented in daily rheumatologic practice...
  78. doi request reprint HLA-DRhigh/CD27high plasmablasts indicate active disease in patients with systemic lupus erythematosus
    A M Jacobi
    Charite Universitatsmedizin Berlin, Chariteplatz 1, 10098 Berlin, Germany
    Ann Rheum Dis 69:305-8. 2010
    ..A similar subset has also been identified 6-8 days after tetanus/diphtheria vaccination in normal individuals and in patients with infectious disease...
  79. ncbi request reprint Short-term effects of the 21-aminosteroid lazaroid tirilazad mesylate (PNU-74006F) and the pyrrolopyrimidine lazaroid PNU-101033E on energy metabolism of human peripheral blood mononuclear cells
    D Schmid
    Department of Medicine (Rheumatology, , Humboldt University, Berlin, Germany
    Biosci Rep 21:101-10. 2001
    ....
  80. ncbi request reprint Insights from a novel three-dimensional in vitro model of lyme arthritis: standardized analysis of cellular and molecular interactions between Borrelia burgdorferi and synovial explants and fibroblasts
    J K Franz
    , Berlin, Germany
    Arthritis Rheum 44:151-62. 2001
    ....
  81. doi request reprint German guidelines for the sequential medical treatment of rheumatoid arthritis with traditional and biologic disease-modifying antirheumatic drugs
    Katinka Albrecht
    German Society of Rheumatology, Berlin, Germany
    Rheumatol Int 34:1-9. 2014
    ..In addition, more recent evidence from a systematic literature research was considered. They have been developed and approved by a group of national experts aiming at guidance for rheumatologists to reach best medical practice. ..
  82. doi request reprint Frequency and duration of drug-free remission after 1 year of treatment with etanercept versus sulfasalazine in early axial spondyloarthritis: 2 year data of the ESTHER trial
    In Ho Song
    Department of Rheumatology, Charité Medical University, Campus Benjamin Franklin, Berlin, Germany
    Ann Rheum Dis 71:1212-5. 2012
    ....
  83. pmc Initial clinical trial of epratuzumab (humanized anti-CD22 antibody) for immunotherapy of systemic lupus erythematosus
    Thomas Dorner
    Department of Medicine Rheumatology and Clinical Immunology, Charite Hospital, Berlin, Germany
    Arthritis Res Ther 8:R74. 2006
    ..As such, multicenter controlled studies are being conducted in broader patient populations...
  84. doi request reprint New approaches of B-cell-directed therapy: beyond rituximab
    Thomas Dorner
    Charite Center 14, Charite University Hospital Berlin, Berlin, Germany
    Curr Opin Rheumatol 20:263-8. 2008
    ..This study reviews therapeutic approaches of direct and indirect B-cell targeting in autoimmune diseases and their impact on protective immunity...
  85. doi request reprint CTLA-4 (CD152) controls homeostasis and suppressive capacity of regulatory T cells in mice
    Paula Kolar
    Deutsches Rheuma ForschungsZentrum Berlin, and Charité University Hospital, Berlin, Germany
    Arthritis Rheum 60:123-32. 2009
    ..The present study was undertaken to investigate the role of CTLA-4 in controlling the homeostasis and suppressive function of Treg cells...
  86. pmc Autoregulation of Th1-mediated inflammation by twist1
    Uwe Niesner
    German Rheumatism Research Center Berlin, 10117 Berlin, Germany
    J Exp Med 205:1889-901. 2008
    ....
  87. pmc Perspectives and limitations of gene expression profiling in rheumatology: new molecular strategies
    Thomas Häupl
    Department of Rheumatology, Charite, Berlin, Germany
    Arthritis Res Ther 6:140-6. 2004
    ..Genomic and proteomic technologies will therefore be complementary in their scientific and clinical application...
  88. ncbi request reprint Immunopathologic role of B lymphocytes in rheumatoid arthritis: rationale of B cell-directed therapy
    Lorena Martinez-Gamboa
    Charité Universitätsmedizin Berlin and German Centre for Rheumatic Research DRFZ, Schumannstr 20 21, 10098 Berlin, Germany
    Autoimmun Rev 5:437-42. 2006
    ..Future studies should clarify which functions are affected by B cell depletion, providing the promise of new avenues to patient-tailored therapies...
  89. doi request reprint A clinical perspective of rheumatoid arthritis
    Hans Ulrich Scherer
    Department of Rheumatology and Clinical Immunology, Charite University Medicine Berlin, Germany
    Eur J Immunol 39:2044-8. 2009
    ..Some of the novel pathogenetic aspects, however, already influence decision making in the clinic...
  90. ncbi request reprint Identification and characterization of SmD183-119-reactive T cells that provide T cell help for pathogenic anti-double-stranded DNA antibodies
    Gabriela Riemekasten
    University of California, Los Angeles, USA
    Arthritis Rheum 48:475-85. 2003
    ..This study was undertaken to test the hypothesis that SmD1(83-119)-reactive T cells play a crucial role in the generation of pathogenic anti-double-stranded DNA (anti-dsDNA) antibodies...
  91. ncbi request reprint Porcine mesenchymal stem cells. Induction of distinct mesenchymal cell lineages
    Jochen Ringe
    Department of Rheumatology, University Medical Center, Charite, The Humboldt University of Berlin, Germany
    Cell Tissue Res 307:321-7. 2002
    ..Therefore, porcine MSC may be introduced as a valuable model system with which to study the mesenchymal lineages for basic research and tissue engineering...
  92. pmc Multiple functions for CD28 and cytotoxic T lymphocyte antigen-4 during different phases of T cell responses: implications for arthritis and autoimmune diseases
    Monika C Brunner-Weinzierl
    Molecular Immunology, Deutsches Rheuma ForschungsZentrum Berlin, Germany
    Arthritis Res Ther 6:45-54. 2004
    ..In particular, CTLA-4 exerts independent distinct effects during different phases of T cell responses that could be exploited for the treatment of rheumatoid arthritis...
  93. doi request reprint Involvement of functional autoantibodies against vascular receptors in systemic sclerosis
    Gabriela Riemekasten
    Department of Nephrology and Intensive Care Medicine, Charité University Hospital Campus Virchow Klinikum, Augustenburger Platz 1, 13353 Berlin, Germany
    Ann Rheum Dis 70:530-6. 2011
    ..The renin-angiotensin and endothelin systems have been implicated in vasculopathy and fibrosis. A role for autoantibody-mediated receptor stimulation is hypothesised, linking three major pathophysiological features consistent with SSc...
  94. ncbi request reprint Knee osteoarthritis. Efficacy of a new method of contrast-enhanced musculoskeletal ultrasonography in detection of synovitis in patients with knee osteoarthritis in comparison with magnetic resonance imaging
    I H Song
    Department of Rheumatology and Clinical Immunology, Charite, Humboldt University of Berlin, Germany
    Ann Rheum Dis 67:19-25. 2008
    ....
  95. doi request reprint Induced apoptosis of chondrocytes by Porphyromonas gingivalis as a possible pathway for cartilage loss in rheumatoid arthritis
    E Rohner
    Department of Rheumatology and Clinical Immunology, Charite University Hospital, Berlin, Germany
    Calcif Tissue Int 87:333-40. 2010
    ..The data show that P. gingivalis promotes early and later stages of apoptosis of primary human chondrocytes, which might contribute to the joint damage seen in the pathogenesis of RA...
  96. doi request reprint Effects of hypoxia and/or lack of glucose on cellular energy metabolism and cytokine production in stimulated human CD4+ T lymphocytes
    R Dziurla
    Department of Rheumatology and Clinical Immunology, Charite University Hospital, Chariteplatz 1, Berlin, Germany
    Immunol Lett 131:97-105. 2010
    ..Hypoxia seems to facilitate inflammatory reactions and angiogenesis...
  97. doi request reprint [Pathogenesis of parodontitis in rheumatic diseases]
    J Detert
    Klinik mit Schwerpunkt Rheumatologie und klinische Immunologie, Charite Universitatsmedizin Berlin, Berlin, Deutschland
    Z Rheumatol 69:109-12, 114-6. 2010
    ..PD and rheumatologic diseases such as RA share many pathological aspects and immunological findings...
  98. doi request reprint CD11c as a transcriptional biomarker to predict response to anti-TNF monotherapy with adalimumab in patients with rheumatoid arthritis
    B Stuhlmuller
    Department of Rheumatology and Clinical Immunology, Charite University Hospital, Humboldt University of Berlin, Berlin, Germany
    Clin Pharmacol Ther 87:311-21. 2010
    ..Larger studies, including studies of monotherapy with other drugs, are now needed to confirm and validate the specificity of CD11c for anti-TNF biologics...
  99. ncbi request reprint Analyses of similarities and differences in glucocorticoid therapy between rheumatoid arthritis and ankylosing spondylitis - a systematic comparison
    C M Spies
    Department of Rheumatology and Clinical Immunology, Charite University Hospital, Berlin, Germany
    Clin Exp Rheumatol 27:S152-8. 2009
    ..Translation of insights on GC action and resistance obtained in RA to AS may contribute to a better understanding of the pathophysiology of both diseases...