Research Topics
Genomes and GenesSpecies | T BurmeisterSummaryAffiliation: Humboldt University Country: Germany Publications
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Detail Information
Publications
Patients' age and BCR-ABL frequency in adult B-precursor ALL: a retrospective analysis from the GMALL study groupThomas Burmeister
Blood 112:918-9. 2008
Molecular monitoring of minimal residual disease in two patients with MLL-rearranged acute myeloid leukemia and haploidentical transplantation after relapseThomas Burmeister
Klinik für Hämatologie, Charite CBF, Hindenburgdamm 30, 12200, Berlin, Germany
Exp Hematol Oncol 1:6. 2012....
Fine structure of translocation breakpoints within the major breakpoint region in BCR-ABL1-positive leukemiasThomas Burmeister
Charite, CBF, Medizinische Klinik für Hämatologie, Onkologie, Hindenburgdamm 30, 12200 Berlin, Germany
DNA Repair (Amst) 10:1131-7. 2011....- Clinical features and prognostic implications of TCF3-PBX1 and ETV6-RUNX1 in adult acute lymphoblastic leukemiaThomas Burmeister
Med Klinik für Hämatologie Onkologie Hindenburgdamm 30, 12200 Berlin, Germany
Haematologica 95:241-6. 2010..However, the prognostic impact of other rarer fusion genes is less well established in adult acute lymphoblastic leukemia than in the childhood form... - The MLL recombinome of adult CD10-negative B-cell precursor acute lymphoblastic leukemia: results from the GMALL study groupThomas Burmeister
Charite Universitatsmedizin Berlin, Campus Benjamin Franklin CBF, Medizinische Klinik III, Berlin, Germany
Blood 113:4011-5. 2009..Characteristic features of MLL(+) patients were significantly lower CD10 expression, expression of the NG2 antigen, a higher white blood count at diagnosis, and female sex. Proposals are made for diagnostic assessment... - A MLL-KIAA0284 fusion gene in a patient with secondary acute myeloid leukemia and t(11;14)(q23;q32)Thomas Burmeister
Charite Universitatsmedizin Berlin, Campus Benjamin Franklin CBF, Medizinische Klinik III, Hindenburgdamm 30, 12200 Berlin, Germany
Blood Cells Mol Dis 41:210-4. 2008..The expression of KIAA0284 in various tissues and hematologic diseases was investigated by real time quantitative PCR and turned out to be very low in all lymphatic and myeloid diseases investigated... - Atypical BCR-ABL mRNA transcripts in adult acute lymphoblastic leukemiaThomas Burmeister
Charite Universitatsmedizin Berlin, Campus, Benjamin Franklin, Medizinische Klinik III, Hindenburgdamm 30, 12200 Berlin, Germany
Haematologica 92:1699-702. 2007..This corresponds to a prevalence of 1-2% of all BCR-ABL-positive cases. The clinical courses are reported and diagnostic proposals are made... - A multiplex PCR for improved detection of typical and atypical BCR-ABL fusion transcriptsThomas Burmeister
Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Medizinische Klinik III, Hindenburgdamm 30, 12200 Berlin, Germany
Leuk Res 32:579-85. 2008..We present here a novel, fast, and reliable multiplex PCR for improved detection of typical and atypical BCR-ABL transcripts... - No genetic evidence for involvement of Deltaretroviruses in adult patients with precursor and mature T-cell neoplasmsThomas Burmeister
Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Medizinische Klinik III, Hindenburgdamm 30, 12200 Berlin, Germany
Retrovirology 4:11. 2007..The primer sequences were based on highly interspecies-conserved virus genome regions. We used this PCR to detect Deltaretroviruses in samples from adult patients with a variety of rare T-cell neoplasms in Germany... - NUP214-ABL1 in adult T-ALL: the GMALL study group experienceThomas Burmeister
Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Medizinische Klinik III, Hindenburgdamm 30, 12200 Berlin, Germany
Blood 108:3556-9. 2006..Based on the results, we have established and tested a novel PCR method for simplified detection of the NUP214-ABL1 fusion gene... - Monitoring minimal residual disease by quantification of genomic chromosomal breakpoint sequences in acute leukemias with MLL aberrationsT Burmeister
Medizinische Klinik III, Campus Benjamin Franklin, Charite Universitatsmedizin Berlin, Hindenburgdamm 30, Berlin, Germany
Leukemia 20:451-7. 2006..An accurate and absolute quantification of the MRD level is possible. No reference to housekeeping genes is necessary and the target structure is much more stable than any mRNA fusion transcript... - Molecular heterogeneity of sporadic adult Burkitt-type leukemia/lymphoma as revealed by PCR and cytogenetics: correlation with morphology, immunology and clinical featuresT Burmeister
Charite, Campus Benjamin Franklin, Medizinische Klinik III, Berlin, Germany
Leukemia 19:1391-8. 2005..A total of 34 patients were treated according to the GMALL B-ALL therapy protocols and there was no significant difference in overall survival between patients with or without t(8;14)... - A novel sporadic Burkitt lymphoma cell line (BLUE-1) with a unique t(6;20)(q15;q11.2) rearrangementThomas Burmeister
Medizinische Klinik III, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, Germany
Leuk Res 30:1417-23. 2006..Our findings are discussed in light of the current understanding of endemic and sporadic Burkitt lymphoma. BLUE-1 grows well in culture and should be a useful lymphoma research tool... - Thymic adult T-cell acute lymphoblastic leukemia stratified in standard- and high-risk group by aberrant HOX11L2 expression: experience of the German multicenter ALL study groupU Baak
Charite Campus Benjamin Franklin, Medizinische Klinik III, Berlin, Germany
Leukemia 22:1154-60. 2008..Thus, patients with aberrant HOX11L2 expression should be considered early as candidates for intensified treatment regimes... - High BAALC expression predicts chemoresistance in adult B-precursor acute lymphoblastic leukemiaAndrea Kühnl
Medizinische Klinik III, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, 12203 Berlin, Germany
Blood 115:3737-44. 2010..Determination of BAALC might contribute to risk assessment of molecularly undefined adult B-precursor ALL... - Combined automated cell and flow cytometric analysis enables recognition of persistent polyclonal B-cell lymphocytosis (PPBL), a study of 25 patientsM Schmidt-Hieber
Medizinische Klinik III, Charite Universitatsmedizin Berlin, Hindenburgdamm 30, 12200, Berlin, Germany
Ann Hematol 87:829-36. 2008..The observation of malignant lymphoma in a single patient implicates that evolution into a clonal malignant transformation may occasionally occur in PPBL... - A PCR primer system for detecting oncoretroviruses based on conserved DNA sequence motifs of animal retroviruses and its application to human leukaemias and lymphomasT Burmeister
Freie Universitat Berlin, Medizinische Klinik III, Hindenburgdamm 30, 12200 Berlin, Germany
J Gen Virol 82:2205-13. 2001..The retrovirus detection system developed here may be used to confirm suspected retroviral involvement in other (malignant or nonmalignant) human diseases as well as to identify new animal retroviruses... - Expression of the human homologue of rat NG2 in adult acute lymphoblastic leukemia: close association with MLL rearrangement and a CD10(-)/CD24(-)/CD65s(+)/CD15(+) B-cell phenotypeS Schwartz
Medizinische Klinik III, , Onkologie und Transfusionsmedizin, Klinikum Benjamin Franklin, , Berlin, Germany
Leukemia 17:1589-95. 2003..As NG2 is negative in non-malignant hematopoietic cells, this novel antigen might also serve in future studies as a powerful marker in monitoring minimal residual disease... - Melting point assay for the JAK2 V617F mutation, comparison with amplification refractory mutation system (ARMS) in diagnostic samples, and implications for daily routineSebastian Ochsenreither
Department of Hematology and Oncology, Charite Berlin, Campus Benjamin Franklin, Berlin, Germany
Mol Diagn Ther 14:185-90. 2010..A multitude of methods has been applied to both qualitative and quantitative assessment of the mutational status of patients, without defining a gold standard for the daily diagnostic routine so far... - Expression of interleukin 15 in primary adult acute lymphoblastic leukemiaShuling Wu
Department of Hematology, Oncology and Transfusion Medicine, Campus Benjamin Franklin, Charity Medical Center, Hindenburgdamm 30, 12203 Berlin, Germany
Cancer 116:387-92. 2010..We determined the expression of IL-15 in lymphoblasts and evaluated its potential impact on the outcome in adult acute lymphoblastic leukemia (ALL)... - Prognostic implications of NOTCH1 and FBXW7 mutations in adult acute T-lymphoblastic leukemiaClaudia D Baldus
Charite, University Hospital Berlin, Campus Benjamin Franklin, Department of Hematology and Oncology, Hindenburgdamm 30 12203 Berlin, Germany
Haematologica 94:1383-90. 2009..However, the results of studies on the prognostic significance of NOTCH1 mutations in adult T-lymphoblastic leukemia remain controversial... - Long distance polymerase chain reaction of ascites lymphoma cells aids diagnosis establishment of abdominal Burkitt's lymphoma and Burkitt-like lymphomaKristoph Jahnke
Department of Hematology, Oncolgy and Transfusion Medicine, Charite Universitatsmedizin Berlin, Germany
Leuk Lymphoma 46:83-6. 2005..Long distance PCR analysis of ascites lymphoma cells for the detection of the BL-typical c-myc rearrangement offers a convenient and rapid possibility of diagnosis verification in atypical or borderline cases of BL... - CD56 expression in T-cell acute lymphoblastic leukemia is associated with non-thymic phenotype and resistance to induction therapy but no inferior survival after risk-adapted therapyLars Fischer
Charite Campus Benjamin Franklin, Medizinische Klinik III, Berlin
Haematologica 94:224-9. 2009..Expression of CD56 has been associated with poor prognosis in acute myeloid leukemia and aggressive lymphoma... - High expression of the ETS transcription factor ERG predicts adverse outcome in acute T-lymphoblastic leukemia in adultsClaudia D Baldus
Department of Hematology, Oncology and Transfusion Medicine, Charite, Campus Benjamin Franklin, University Hospital Berlin, Hindenburgdamm 30, 12203 Berlin, Germany
J Clin Oncol 24:4714-20. 2006..The adverse prognosis in T-ALL has not been attributed to cytogenetic or molecular aberrations. We have determined the prognostic impact of the oncogenic transcription factor ERG in T-ALL... - Skewed expression of natural-killer (NK)-associated antigens on lymphoproliferations of large granular lymphocytes (LGL)Lars Fischer
Department of Hematology, Oncology and Transfusion Medicine, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Germany
Hematol Oncol 24:78-85. 2006..We consistently found a skewed expression pattern of novel NK markers as a pathological feature of LGLL. These antigens should be included in the diagnostic workup of this rare disease... - Low ERG and BAALC expression identifies a new subgroup of adult acute T-lymphoblastic leukemia with a highly favorable outcomeClaudia D Baldus
Department of Hematology and Oncology, Charite, University Hospital Berlin, Campus Benjamin Franklin, Berlin, Germany
J Clin Oncol 25:3739-45. 2007..We hypothesized that like ERG, BAALC expression might be of prognostic significance in acute T-lymphoblastic leukemia (T-ALL) and that ERG and BAALC expression together would better identify the patient's risk profile... - Detection of subclinical systemic disease in primary CNS lymphoma by polymerase chain reaction of the rearranged immunoglobulin heavy-chain genesKristoph Jahnke
Department of Hematology, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany
J Clin Oncol 24:4754-7. 2006.... - Insertional polymorphisms of endogenous HERV-K113 and HERV-K115 retroviruses in breast cancer patients and age-matched controlsThomas Burmeister
Medizinische Klinik III, , 12200 Berlin, Germany
AIDS Res Hum Retroviruses 20:1223-9. 2004..This suggests that the two HERV-Ks do not play a pathogenetic role in the majority of breast cancer patients, though they may be involved in a minority of patients. The results are discussed...