Karl Heinz Braunewell

Summary

Affiliation: Humboldt University
Country: Germany

Publications

  1. ncbi request reprint Intracellular neuronal calcium sensor (NCS) protein VILIP-1 modulates cGMP signalling pathways in transfected neural cells and cerebellar granule neurones
    K H Braunewell
    Signal Transduction Research Group, Leibniz Institute for Neurobiology Magdeburg, Germany
    J Neurochem 78:1277-86. 2001
  2. ncbi request reprint The darker side of Ca2+ signaling by neuronal Ca2+-sensor proteins: from Alzheimer's disease to cancer
    Karl Heinz Braunewell
    Signal Transduction Research Group, Neuroscience Research Center of the Charité Berlin, Tucholskystr 2, 10117 Berlin, Germany
    Trends Pharmacol Sci 26:345-51. 2005
  3. ncbi request reprint Group I mGlu receptors regulate the expression of the neuronal calcium sensor protein VILIP-1 in vitro and in vivo: implications for mGlu receptor-dependent hippocampal plasticity?
    K H Braunewell
    Signal Transduction Research Group, Neuroscience Research Center of the Charite, Humboldt University, Tucholskystr 2, D 10117, Berlin, Germany
    Neuropharmacology 44:707-15. 2003
  4. ncbi request reprint Reversible translocation and activity-dependent localization of the calcium-myristoyl switch protein VILIP-1 to different membrane compartments in living hippocampal neurons
    Christina Spilker
    Neuroscience Research Center Institute for Physiology of the Charite, Humboldt University Berlin, Signal Transduction Research Group, D 10117 Berlin, Germany
    J Neurosci 22:7331-9. 2002
  5. ncbi request reprint MGluRs regulate the expression of neuronal calcium sensor proteins NCS-1 and VILIP-1 and the immediate early gene arg3.1/arc in the hippocampus in vivo
    Marian Brackmann
    Signal Transduction Research Group, Neuroscience Research Center of the Charite, Tucholskystrasse 2, D 10117 Berlin, Germany
    Biochem Biophys Res Commun 322:1073-9. 2004
  6. ncbi request reprint Neuronal Ca2+ sensor protein VILIP-1 affects cGMP signalling of guanylyl cyclase B by regulating clathrin-dependent receptor recycling in hippocampal neurons
    Marian Brackmann
    Signal Transduction Research Group, Charite, University Medicine, 10117 Berlin, Germany
    J Cell Sci 118:2495-505. 2005
  7. ncbi request reprint Cellular and subcellular localization of the inhibitory glycine receptor in hippocampal neurons
    Marian Brackmann
    Signal Transduction Research Group, Neuroscience Research Center, Charite Berlin, Tucholskystrasse 2, D 10117 Berlin, Germany
    Biochem Biophys Res Commun 324:1137-42. 2004
  8. ncbi request reprint Calcium-myristoyl switch, subcellular localization, and calcium-dependent translocation of the neuronal calcium sensor protein VILIP-3, and comparison with VILIP-1 in hippocampal neurons
    Christina Spilker
    Signal Transduction Research Group, Neuroscience Research Center Institute for Physiology of the Charite, Humboldt University Berlin, Tucholskystrasse 2, D 10117 Berlin, Germany
    Mol Cell Neurosci 24:766-78. 2003
  9. doi request reprint Nicotine-induced Ca2+-myristoyl switch of neuronal Ca2+ sensor VILIP-1 in hippocampal neurons: a possible crosstalk mechanism for nicotinic receptors
    Congjian Zhao
    Signal Transduction Research Group, Neuroscience Research Center, Charite Universitaetsmedizin Berlin, Berlin, Germany
    Cell Mol Neurobiol 29:273-86. 2009
  10. ncbi request reprint Expression analysis of members of the neuronal calcium sensor protein family: combining bioinformatics and Western blot analysis
    Paul Gierke
    Signal Transduction Research Group, Charite Berlin, Tucholskystr 2, D 10117 Berlin, Germany
    Biochem Biophys Res Commun 323:38-43. 2004

Collaborators

Detail Information

Publications25

  1. ncbi request reprint Intracellular neuronal calcium sensor (NCS) protein VILIP-1 modulates cGMP signalling pathways in transfected neural cells and cerebellar granule neurones
    K H Braunewell
    Signal Transduction Research Group, Leibniz Institute for Neurobiology Magdeburg, Germany
    J Neurochem 78:1277-86. 2001
    ..Together with the observed colocalization of GC-B, but not GC-A, with VILIP-1 in cerebellar granule cells, these results suggest that VILIP-1 may be a physiological regulator of GC-B...
  2. ncbi request reprint The darker side of Ca2+ signaling by neuronal Ca2+-sensor proteins: from Alzheimer's disease to cancer
    Karl Heinz Braunewell
    Signal Transduction Research Group, Neuroscience Research Center of the Charité Berlin, Tucholskystr 2, 10117 Berlin, Germany
    Trends Pharmacol Sci 26:345-51. 2005
    ....
  3. ncbi request reprint Group I mGlu receptors regulate the expression of the neuronal calcium sensor protein VILIP-1 in vitro and in vivo: implications for mGlu receptor-dependent hippocampal plasticity?
    K H Braunewell
    Signal Transduction Research Group, Neuroscience Research Center of the Charite, Humboldt University, Tucholskystr 2, D 10117, Berlin, Germany
    Neuropharmacology 44:707-15. 2003
    ..A specific role for group I mGlu receptors is evident. Furthermore, the sensor proteins may function as molecular switches for the long-term regulation of synaptic plasticity...
  4. ncbi request reprint Reversible translocation and activity-dependent localization of the calcium-myristoyl switch protein VILIP-1 to different membrane compartments in living hippocampal neurons
    Christina Spilker
    Neuroscience Research Center Institute for Physiology of the Charite, Humboldt University Berlin, Signal Transduction Research Group, D 10117 Berlin, Germany
    J Neurosci 22:7331-9. 2002
    ....
  5. ncbi request reprint MGluRs regulate the expression of neuronal calcium sensor proteins NCS-1 and VILIP-1 and the immediate early gene arg3.1/arc in the hippocampus in vivo
    Marian Brackmann
    Signal Transduction Research Group, Neuroscience Research Center of the Charite, Tucholskystrasse 2, D 10117 Berlin, Germany
    Biochem Biophys Res Commun 322:1073-9. 2004
    ..Therefore, mGluRs at concentrations which induce synaptic plasticity regulate the expression of IEGs and NCS proteins in different time frames and thus contribute to late phases of synaptic plasticity...
  6. ncbi request reprint Neuronal Ca2+ sensor protein VILIP-1 affects cGMP signalling of guanylyl cyclase B by regulating clathrin-dependent receptor recycling in hippocampal neurons
    Marian Brackmann
    Signal Transduction Research Group, Charite, University Medicine, 10117 Berlin, Germany
    J Cell Sci 118:2495-505. 2005
    ..g. by influencing cGMP-signalling...
  7. ncbi request reprint Cellular and subcellular localization of the inhibitory glycine receptor in hippocampal neurons
    Marian Brackmann
    Signal Transduction Research Group, Neuroscience Research Center, Charite Berlin, Tucholskystrasse 2, D 10117 Berlin, Germany
    Biochem Biophys Res Commun 324:1137-42. 2004
    ..On the subcellular level we found co-staining of GlyR and the presynaptic marker synapsin I. Furthermore, co-staining with GAD at synaptic terminals indicated partial co-localization of GABA- and glycine receptors...
  8. ncbi request reprint Calcium-myristoyl switch, subcellular localization, and calcium-dependent translocation of the neuronal calcium sensor protein VILIP-3, and comparison with VILIP-1 in hippocampal neurons
    Christina Spilker
    Signal Transduction Research Group, Neuroscience Research Center Institute for Physiology of the Charite, Humboldt University Berlin, Tucholskystrasse 2, D 10117 Berlin, Germany
    Mol Cell Neurosci 24:766-78. 2003
    ..Thus, VILIPs co-expressed in the same neuron show clear differences in calcium-dependent localization which may allow neurons a highly selective response to various calcium stimuli...
  9. doi request reprint Nicotine-induced Ca2+-myristoyl switch of neuronal Ca2+ sensor VILIP-1 in hippocampal neurons: a possible crosstalk mechanism for nicotinic receptors
    Congjian Zhao
    Signal Transduction Research Group, Neuroscience Research Center, Charite Universitaetsmedizin Berlin, Berlin, Germany
    Cell Mol Neurobiol 29:273-86. 2009
    ..VILIP-1 might provide a novel functional crosstalk between alpha4- and alpha7-containing nAChRs...
  10. ncbi request reprint Expression analysis of members of the neuronal calcium sensor protein family: combining bioinformatics and Western blot analysis
    Paul Gierke
    Signal Transduction Research Group, Charite Berlin, Tucholskystr 2, D 10117 Berlin, Germany
    Biochem Biophys Res Commun 323:38-43. 2004
    ....
  11. doi request reprint Implication of neuronal Ca2+ -sensor protein VILIP-1 in the glutamate hypothesis of schizophrenia
    Paul Gierke
    Signal Transduction Research Group, Neuroscience Research Center, Charite, Universitaetsmedizin Berlin, Germany
    Neurobiol Dis 32:162-75. 2008
    ....
  12. doi request reprint Visinin-like protein 1 regulates natriuretic peptide receptor B in the heart
    Jens Buttgereit
    Max Delbrück Center for Molecular Medicine MDC, Campus Berlin Buch, Berlin, Germany
    Regul Pept 161:51-7. 2010
    ..In conclusion, VILIP-1 deficiency may be responsible for the reduced efficiency of the natriuretic peptide system in cardiac hypertrophy and heart failure and may therefore serve as pharmacological target...
  13. doi request reprint C-Type natriuretic peptide modulates pre- and postsynaptic properties in hippocampal area CA1 in vitro
    Jochen Martin Decker
    Institute for Neurophysiology, Johannes Müller Ctr of Physiology, Charite Universitatsmedizin Berlin, Tucholskystrasse 2, 10117 Berlin, Germany
    Biochem Biophys Res Commun 377:820-5. 2008
    ..The observed pre-and postsynaptic effects after CNP stimulation of the cGMP pathway in hippocampal cell cultures may underlie the effect of the peptide hormone on LTP...
  14. ncbi request reprint Correlation of visinin-like-protein-1 expression with clinicopathological features in squamous cell carcinoma of the esophagus
    Carla Wickborn
    Signal Transduction Research Group, Neuroscience Research Center Institute for Physiology, Charite Universitatsmedizin Berlin, Campus Mitte, Berlin, Germany
    Mol Carcinog 45:572-81. 2006
    ..The protein expression level significantly correlates with invasive features, such as depth of tumor invasion and local lymph node metastasis, but not with proliferation rate of tumor cells...
  15. pmc Involvement of VILIP-1 (visinin-like protein) and opposite roles of cyclic AMP and GMP signaling in in vitro cell migration of murine skin squamous cell carcinoma
    Katharina Schönrath
    Signal Transduction Research Group, Institute for Neurophysiology, Charite, Universitatsmedizin Berlin, Berlin, Germany
    Mol Carcinog 50:319-33. 2011
    ....
  16. ncbi request reprint Hippocampal expression of the calcium sensor protein visinin-like protein-1 in schizophrenia
    Hans Gert Bernstein
    Department of Psychiatry of the University Magdeburg, Leipziger Str 44, D 39120, Germany
    Neuroreport 13:393-6. 2002
    ..In schizophrenics fewer pyramidal cells but more interneurons were immunostained. Our data point to an involvement of the protein in the altered hippocampal circuitry in schizophrenia...
  17. ncbi request reprint Functional analysis of calcium-binding EF-hand motifs of visinin-like protein-1
    Lin Lin
    Neuroscience Center of Excellence, 2020 Gravier Street, Suite D, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
    Biochem Biophys Res Commun 296:827-32. 2002
    ..These results show that the calcium-binding EF-hand motifs of VILIP-1 do not have an essential role in modulating adenylyl cyclase activity but instead have a structural role in activating the "calcium-myristoyl switch" of VILIP-1...
  18. ncbi request reprint Visinin-like protein-1 is a potent inhibitor of cell adhesion and migration in squamous carcinoma cells
    Anatilde M Gonzalez Guerrico
    Department of Pathology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Oncogene 24:2307-16. 2005
    ..Decreased or absent VILIP-1 expression in SCC cell subpopulations may lead to a more advanced malignant phenotype characterized by changes in adhesive ability and increased cell motility, suggestive of a tumor suppressor function...
  19. ncbi request reprint The metabotropic glutamate receptor, mGluR5, is a key determinant of good and bad spatial learning performance and hippocampal synaptic plasticity
    Denise Manahan-Vaughan
    Learning and Memory Research, International Graduate School for Neuroscience, Ruhr University Bochum, FNO 1 116, Universitaetsstrasse 150, 44780 Bochum, Germany
    Cereb Cortex 15:1703-13. 2005
    ..MGluR1 expression was equivalent. These data reveal striking mGluR5-dependent differences in spatial learning in different rat strains, which correlate to synaptic plasticity and mGluR5 expression levels...
  20. ncbi request reprint The calcium sensor protein visinin-like protein-1 modulates the surface expression and agonist sensitivity of the alpha 4beta 2 nicotinic acetylcholine receptor
    Lin Lin
    Neuroscience Center of Excellence, Louisiana, New Orleans 70112, USA
    J Biol Chem 277:41872-8. 2002
    ..Collectively, these results suggest that VILIP-1 represents a novel modulator of alpha4beta2 AChRs that increases their surface expression levels and agonist sensitivity in response to changes in the intracellular levels of calcium...
  21. ncbi request reprint Brain region-specific changes in the expression of calcium sensor proteins after repeated applications of ketamine to rats
    Hans Gert Bernstein
    Department of Psychiatry, University of Magdeburg, Leipziger Strasse 44, D 39120, Magdeburg, Germany
    Neurosci Lett 339:95-8. 2003
    ..G., Braunewell, K.-H., Spilker, C., Danos, P., Baumann, B., Funke, S., Diekmann, S., Gundelfinger, E.D. and Bogerts, B., NeuroReport, 13 (2002) 393-396]...
  22. ncbi request reprint Overexpression of the calcium sensor visinin-like protein-1 leads to a cAMP-mediated decrease of in vivo and in vitro growth and invasiveness of squamous cell carcinoma cells
    Haleh Mahloogi
    Department of Pathology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Cancer Res 63:4997-5004. 2003
    ..These results indicate that VILIP-1 plays an important role in regulating tumor cell invasiveness and that its loss could aid in enhancing the advanced malignant phenotype...
  23. ncbi request reprint The neuronal Ca2+ sensor protein visinin-like protein-1 is expressed in pancreatic islets and regulates insulin secretion
    Feihan F Dai
    Department of Physiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada
    J Biol Chem 281:21942-53. 2006
    ..Increased VILIP-1 enhanced insulin secretion in a cAMP-associated manner. Down-regulation of VILIP-1 was accompanied by decreased cAMP accumulation but increased insulin gene transcription...
  24. pmc VILIP-1 downregulation in non-small cell lung carcinomas: mechanisms and prediction of survival
    Jian Fu
    Department of Pathology, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA
    PLoS ONE 3:e1698. 2008
    ....
  25. ncbi request reprint Expression of visinin-like protein-3 in mouse kidney
    Sandra Pribanic
    Institute of Physiology, University of Zurich, Zurich, Switzerland
    Nephron Physiol 95:p76-82. 2003
    ..In addition VILIP-3 was observed in the brush borders of proximal tubular S1 and S3 segments of both superficial and deep nephrons...