Michael Boschmann

Summary

Affiliation: Humboldt University
Country: Germany

Publications

  1. ncbi request reprint Adipose tissue metabolism and CD11b expression on monocytes in obese hypertensives
    Michael Boschmann
    Franz Volhard Clinical Research Center, Charite Campus Buch, HELIOS Klinikum, Berlin, Germany
    Hypertension 46:130-6. 2005
  2. ncbi request reprint Hemodynamic and metabolic responses to interstitial angiotensin II in normal weight and obese men
    Michael Boschmann
    Franz Volhard Clinical Research Center, Charite, Universitary Medicine Berlin, Germany
    J Hypertens 24:1165-71. 2006
  3. pmc LMNA mutations, skeletal muscle lipid metabolism, and insulin resistance
    Michael Boschmann
    Franz Volhard Clinical Research Center at the Experimental and Clinical Research Center, University Hospital Charite Campus Buch and HELIOS Klinikum Berlin, 13125 Berlin, Germany
    J Clin Endocrinol Metab 95:1634-43. 2010
  4. ncbi request reprint The effects of epigallocatechin-3-gallate on thermogenesis and fat oxidation in obese men: a pilot study
    Michael Boschmann
    Universitary Medicine Berlin, Charite Campus Buch, Franz Volhard Center for Clinical Research, D 13125, Berlin, Germany
    J Am Coll Nutr 26:389S-395S. 2007
  5. pmc Beta-adrenergic and atrial natriuretic peptide interactions on human cardiovascular and metabolic regulation
    Andreas L Birkenfeld
    Franz Volhard Clinical Research Center, Haus 129, Charite Campus Buch, Wiltbergstr 50, 13125 Berlin, Germany
    J Clin Endocrinol Metab 91:5069-75. 2006
  6. pmc Atrial natriuretic peptide induces postprandial lipid oxidation in humans
    Andreas L Birkenfeld
    Experimental and Clinical Research Center, Charité and HELIOS Klinikum, Berlin, Germany
    Diabetes 57:3199-204. 2008
  7. doi request reprint Myocardial steatosis, cardiac remodelling and fitness in insulin-sensitive and insulin-resistant obese women
    Wolfgang Utz
    Working Group Cardiac MR Medical Faculty of the Charité Campus Buch and HELIOS Klinikum Berlin Buch, Berlin, Germany
    Heart 97:1585-9. 2011
  8. doi request reprint Moderate dietary weight loss reduces myocardial steatosis in obese and overweight women
    Wolfgang Utz
    Working Group Cardiac MR, Medical Faculty of the Charité Campus Buch and HELIOS Klinikum Berlin Buch, Berlin, Germany
    Int J Cardiol 167:905-9. 2013
  9. ncbi request reprint Dissociation between adipose nitric oxide synthase expression and tissue metabolism
    Stefan Engeli
    Franz Volhard Clinical Research Center, Charite Campus Buch, Wiltbergstrasse 50, 13125 Berlin, Germany
    J Clin Endocrinol Metab 92:2706-11. 2007
  10. ncbi request reprint Phenotypical evidence for a gender difference in cardiac norepinephrine transporter function
    Christoph Schroeder
    Franz Volhard Clinical Research Center, Haus 129, Medical Faculty of the Charité Campus Buch, Wiltbergstrasse 50, 13125 Berlin, Germany
    Am J Physiol Regul Integr Comp Physiol 286:R851-6. 2004

Collaborators

Detail Information

Publications44

  1. ncbi request reprint Adipose tissue metabolism and CD11b expression on monocytes in obese hypertensives
    Michael Boschmann
    Franz Volhard Clinical Research Center, Charite Campus Buch, HELIOS Klinikum, Berlin, Germany
    Hypertension 46:130-6. 2005
    ..These findings may be explained in part by monocyte/macrophage infiltration of adipose tissue, which appears to interfere with insulin responsiveness...
  2. ncbi request reprint Hemodynamic and metabolic responses to interstitial angiotensin II in normal weight and obese men
    Michael Boschmann
    Franz Volhard Clinical Research Center, Charite, Universitary Medicine Berlin, Germany
    J Hypertens 24:1165-71. 2006
    ..Therefore, we hypothesized that peripheral tissues of obese subjects are hypersensitive to angiotensin (Ang) II...
  3. pmc LMNA mutations, skeletal muscle lipid metabolism, and insulin resistance
    Michael Boschmann
    Franz Volhard Clinical Research Center at the Experimental and Clinical Research Center, University Hospital Charite Campus Buch and HELIOS Klinikum Berlin, 13125 Berlin, Germany
    J Clin Endocrinol Metab 95:1634-43. 2010
    ..The symptoms may all be explained by defective metabolism; however, metabolism at the tissue level has not been investigated...
  4. ncbi request reprint The effects of epigallocatechin-3-gallate on thermogenesis and fat oxidation in obese men: a pilot study
    Michael Boschmann
    Universitary Medicine Berlin, Charite Campus Buch, Franz Volhard Center for Clinical Research, D 13125, Berlin, Germany
    J Am Coll Nutr 26:389S-395S. 2007
    ..However, human studies investigating the metabolic effects of the most predominant tea catechin, EGCG, alone are absent...
  5. pmc Beta-adrenergic and atrial natriuretic peptide interactions on human cardiovascular and metabolic regulation
    Andreas L Birkenfeld
    Franz Volhard Clinical Research Center, Haus 129, Charite Campus Buch, Wiltbergstr 50, 13125 Berlin, Germany
    J Clin Endocrinol Metab 91:5069-75. 2006
    ..Atrial natriuretic peptide (ANP) has well-known cardiovascular effects and modifies lipid and carbohydrate metabolism in humans...
  6. pmc Atrial natriuretic peptide induces postprandial lipid oxidation in humans
    Andreas L Birkenfeld
    Experimental and Clinical Research Center, Charité and HELIOS Klinikum, Berlin, Germany
    Diabetes 57:3199-204. 2008
    ..We hypothesized that ANP increases postprandial free fatty acid (FFA) availability and energy expenditure while decreasing arterial blood pressure...
  7. doi request reprint Myocardial steatosis, cardiac remodelling and fitness in insulin-sensitive and insulin-resistant obese women
    Wolfgang Utz
    Working Group Cardiac MR Medical Faculty of the Charité Campus Buch and HELIOS Klinikum Berlin Buch, Berlin, Germany
    Heart 97:1585-9. 2011
    ..Lipotoxic injury from altered myocardial metabolism may be causative. Whether such association also exists in obese, non-diabetic women is unknown...
  8. doi request reprint Moderate dietary weight loss reduces myocardial steatosis in obese and overweight women
    Wolfgang Utz
    Working Group Cardiac MR, Medical Faculty of the Charité Campus Buch and HELIOS Klinikum Berlin Buch, Berlin, Germany
    Int J Cardiol 167:905-9. 2013
    ..Previous studies suggest that MTG could be mobilized through lifestyle interventions. We assessed influences of moderate dietary weight loss in non diabetic obese and overweight women on MTG content and cardiac function...
  9. ncbi request reprint Dissociation between adipose nitric oxide synthase expression and tissue metabolism
    Stefan Engeli
    Franz Volhard Clinical Research Center, Charite Campus Buch, Wiltbergstrasse 50, 13125 Berlin, Germany
    J Clin Endocrinol Metab 92:2706-11. 2007
    ..Nitric oxide synthase (NOS) expression in adipose tissue is increased in obese subjects. The functional relevance is not known...
  10. ncbi request reprint Phenotypical evidence for a gender difference in cardiac norepinephrine transporter function
    Christoph Schroeder
    Franz Volhard Clinical Research Center, Haus 129, Medical Faculty of the Charité Campus Buch, Wiltbergstrasse 50, 13125 Berlin, Germany
    Am J Physiol Regul Integr Comp Physiol 286:R851-6. 2004
    ..Our observations suggest that the NET contribution to cardiac norepinephrine turnover may be decreased in women. The gender difference in NET function may not be expressed in tissues that are less NET dependent than the heart...
  11. ncbi request reprint Influences of AT1 receptor blockade on tissue metabolism in obese men
    Michael Boschmann
    Franz Volhard Clinical Research Center, Haus 129, Charite Campus Buch, Wiltbergstr 50, 13125 Berlin, Germany
    Am J Physiol Regul Integr Comp Physiol 290:R219-23. 2006
    ..Endogeneous ANG II may slightly increase adipose tissue lipolysis. The mechanism may promote the redistribution of triglycerides from adipose tissue toward other organs...
  12. ncbi request reprint Hemodynamic and metabolic responses to valsartan and atenolol in obese hypertensive patients
    Jens Jordan
    Franz Volhard Clinical Research Center, Medical Faculty of the Charité and HELIOS Klinikum, Berlin, Germany
    J Hypertens 23:2313-8. 2005
    ..Treatment recommendations for lean hypertensives may not be simply extrapolated to obese hypertensive persons...
  13. doi request reprint Left ventricular mass and function with reduced-fat or reduced-carbohydrate hypocaloric diets in overweight and obese subjects
    Sven Haufe
    Franz Volhard Clinical Research Center at the Experimental and Clinical Research Center, Charité University Medical Faculty and Max Delbrück Center for Molecular Medicine, Berlin, Germany
    Hypertension 59:70-5. 2012
    ..However, n-3 polyunsaturated fatty acid ingestion may have an independent beneficial effect on left ventricular mass...
  14. ncbi request reprint Lipid mobilization with physiological atrial natriuretic peptide concentrations in humans
    Andreas L Birkenfeld
    Franz Volhard Clinical Research Center, Haus 129, Charite Campus Buch, Wiltbergstrasse 50, 13125 Berlin, Germany
    J Clin Endocrinol Metab 90:3622-8. 2005
    ..Atrial natriuretic peptide (ANP) in pharmacological concentrations stimulates lipid mobilization in humans...
  15. ncbi request reprint Water drinking induces thermogenesis through osmosensitive mechanisms
    Michael Boschmann
    Franz Volhard Clinical Research Center and Helios Klinikum Berlin, Charite Campus Buch, Universitary Medicine Berlin, Wiltbergstrasse 50, Hs 129, D 13125 Berlin, Germany
    J Clin Endocrinol Metab 92:3334-7. 2007
    ..Recently, we showed that drinking 500 ml water induces thermogenesis in normal-weight men and women...
  16. ncbi request reprint Dipeptidyl-peptidase-IV inhibition augments postprandial lipid mobilization and oxidation in type 2 diabetic patients
    Michael Boschmann
    Franz Volhard Clinical Research Center, Helios Klinikum and Medical Faculty of the Charité, D 13125 Berlin, Germany
    J Clin Endocrinol Metab 94:846-52. 2009
    ..Dipeptidyl-peptidase-IV (DPP-4) inhibition increases endogenous GLP-1 activity, resulting in improved glycemic control in patients with type 2 diabetes mellitus. The metabolic response may be explained in part by extrapancreatic mechanisms...
  17. ncbi request reprint Angiotensin type 1 receptor antagonists induce human in-vitro adipogenesis through peroxisome proliferator-activated receptor-gamma activation
    Jurgen Janke
    Medical Faculty of the Charite, Franz Volhard Clinic, HELIOS Klinikum Berlin, Berlin, Germany
    J Hypertens 24:1809-16. 2006
    ..In clonal animal cells, certain angiotensin receptor blockers (ARB) activate the peroxisome proliferator-activated receptor-gamma (PPARgamma). The aim of this work was to validate that observation in human cells and humans...
  18. ncbi request reprint Increased catabolic activity in adipose tissue of patients with chronic heart failure
    Tibor Szabo
    Charite University Medicine, Campus Virchow Klinikum, Department of Cardiology, Applied Cachexia Research, Berlin, Germany
    Eur J Heart Fail 15:1131-7. 2013
    ..We tested the hypothesis that increased plasma ANP levels are associated with an increased catabolic (lipolytic) state of white AT in patients with CHF...
  19. doi request reprint Aliskiren penetrates adipose and skeletal muscle tissue and reduces renin-angiotensin system activity in obese hypertensive patients
    Michael Boschmann
    Franz Volhard Clinical Research Center, Charite, Berlin, Germany
    J Hypertens 30:561-6. 2012
    ..Therefore, we investigated whether aliskiren attains tissue concentrations sufficient to inhibit local renin-angiotensin system (RAS) activity in patients...
  20. doi request reprint Randomized comparison of reduced fat and reduced carbohydrate hypocaloric diets on intrahepatic fat in overweight and obese human subjects
    Sven Haufe
    Max Delbruck Center for Molecular Medicine, Berlin, Germany
    Hepatology 53:1504-14. 2011
    ..56%) irrespective of diet composition. In contrast, changes in visceral fat mass and insulin sensitivity were similar between subgroups, with low and high baseline intrahepatic lipids...
  21. ncbi request reprint Retinol-binding protein 4 in human obesity
    Jurgen Janke
    Franz Volhard Clinical Research Center Haus 129, Charite Campus Buch, Wiltbergstr 50, 13125 Berlin, Germany
    Diabetes 55:2805-10. 2006
    ..Our findings point to profound differences between rodents and humans in the regulation of adipose or circulating RBP4 and challenge the notion that glucose uptake by adipocytes has a dominant role in the regulation of RBP4...
  22. pmc Atrial natriuretic peptide and adiponectin interactions in man
    Andreas L Birkenfeld
    Department of Endocrinology, Diabetes and Nutrition, Center for Cardiovascular Research CCR, Charite University School of Medicine, Berlin, Germany
    PLoS ONE 7:e43238. 2012
    ..Our study could have implications for the physiological regulation of adiponectin and for disease states associated with altered natriuretic peptide availability...
  23. doi request reprint Influences of levodopa on adipose tissue and skeletal muscle metabolism in patients with idiopathic Parkinson's disease
    Frauke Adams
    Experimental and Clinical Research Center, A Cooperation with Max Delbrueck Center for Molecular Medicine, Charite Campus Buch, and HELIOS Klinikum, Berlin, Germany
    Eur J Clin Pharmacol 64:863-70. 2008
    ..We assessed systemic and local metabolic responses to levodopa/benserazide in patients with idiopathic Parkinson's disease...
  24. doi request reprint Energy metabolism in human renin-gene transgenic rats: does renin contribute to obesity?
    Petra Gratze
    Franz Volhard Clinical Research Center, Helios Klinikum Berlin Buch, Berlin Buch, Germany
    Hypertension 53:516-23. 2009
    ..The mechanisms are independent of any currently known renin-related effects...
  25. ncbi request reprint Adrenergic responsiveness of adipose tissue lipolysis in autonomic failure
    Jens Jordan
    Medical Faculty of the Charite, Franz Volhard Clinical Research Center, Helios Klinikum and Max Delbrück Center, Berlin, Germany
    Clin Auton Res 14:80-3. 2004
    ..We propose that beta-adrenoreceptor upregulation is compensated by a desensitization of post receptor mechanisms or by an upregulation of antilipolytic pathways...
  26. pmc Is metabolic flexibility altered in multiple sclerosis patients?
    Anja Mähler
    Experimental and Clinical Research Center, A Joint Cooperation between the Charité University Medicine Berlin and Max Delbrueck Center for Molecular Medicine, Berlin, Germany
    PLoS ONE 7:e43675. 2012
    ..Multiple sclerosis (MS) results in reduced muscle strength and exercise intolerance. We tested the hypothesis that altered metabolic flexibility contributes to exercise intolerance in MS patients...
  27. ncbi request reprint Influence of salt intake on renin-angiotensin and natriuretic peptide system genes in human adipose tissue
    Stefan Engeli
    Franz Volhard Clinical Research Center, Medical Faculty of the Charité and HELIOS Klinikum, Berlin, Germany
    Hypertension 48:1103-8. 2006
    ..In contrast, systemic atrial natriuretic peptide and adipose-tissue atrial natriuretic peptide respond similarly to changes in sodium intake...
  28. doi request reprint Bioimpedance and bioimpedance vector analysis in patients with anorexia nervosa
    Verena Haas
    Experimental and Clinical Research Center, a joint cooperation between the Charité Medical Faculty and the Max Delbrück Center for Molecular Medicine, Charite University Clinic, Berlin, Germany
    Eur Eat Disord Rev 20:400-5. 2012
    ..The utility of bioelectrical impedance analysis (BIA) in patients with anorexia nervosa (AN) is imperfectly defined. Furthermore, any advantage accrued by BIA with vector analysis (BIVA) is unknown...
  29. ncbi request reprint Paradoxical effect of sibutramine on autonomic cardiovascular regulation
    Andreas L Birkenfeld
    Franz Volhard Clinical Research Center, Medical Faculty of the Charite, Humboldt University, Berlin, Germany
    Circulation 106:2459-65. 2002
    ..Norepinephrine reuptake inhibition with sibutramine conceivably could exacerbate arterial hypertension and promote cardiovascular disease...
  30. doi request reprint [Effects of fasting and endurance training on energy metabolism and physical fitness in obese patients]
    Jochen Steiniger
    Universitätsmedizin Charité Berlin, Campus Buch, Franz Volhard Centrum für Klinische Forschung am Experimental and Clinical Research Center, Berlin, Deutschland
    Forsch Komplementmed 16:383-90. 2009
    ..Although there are some anecdotal reports about a serious protein loss during this type of fasting, there are no validated data that support this claim...
  31. pmc Cardiorespiratory fitness and insulin sensitivity in overweight or obese subjects may be linked through intrahepatic lipid content
    Sven Haufe
    Franz Volhard Clinical Research Center at Experimental and Clinical Research Center, Charité University Medical School and Max Delbrück Center for Molecular Medicine, Berlin, Germany
    Diabetes 59:1640-7. 2010
    ..Given the close relationship between intrahepatic lipid content (IHL) and insulin sensitivity, we hypothesized that the direct relationship between fitness and insulin sensitivity may be explained by IHL...
  32. ncbi request reprint Increased catabolic state in spinocerebellar ataxia type 1 patients
    Anja Mähler
    Experimental and Clinical Research Center, Charité Universitätsmedizin Berlin and Max Delbrück Centrum für Molekulare Medizin, Lindenberger Weg 80, 13125, Berlin, Germany
    Cerebellum 13:440-6. 2014
    ..healthy controls. An altered autonomic nervous system activity, gait ataxia, and a decreased physical activity might contribute to this outcome. ..
  33. pmc Altered expression of cyclin A 1 in muscle of patients with facioscapulohumeral muscle dystrophy (FSHD-1)
    Anna Pakula
    Experimental and Clinical Research Center, a joint co operation of Charité University Medicine and Max Delbrück Center for Molecular Medicine, Franz Volhard Center for Clinical Research, Berlin, Germany
    PLoS ONE 8:e73573. 2013
    ..Its expression increases in G1/S phase and reaches a maximum in G2 and M phases. Altered cyclin A1 expression might contribute to clinical symptoms in facioscapulohumeral muscular dystrophy (FSHD)...
  34. doi request reprint Resting energy expenditure and the effects of muscle wasting in patients with chronic heart failure: results from the Studies Investigating Comorbidities Aggravating Heart Failure (SICA-HF)
    Matthias Tacke
    Applied Cachexia Research, Department of Cardiology, Charite Medical School, Campus Virchow Klinikum, Berlin, Germany
    J Am Med Dir Assoc 14:837-41. 2013
    ..Glucagonlike peptide 1 (GLP-1) is linked to REE in healthy individuals. We aimed to evaluate (1) whether REE is elevated in patients with HF with muscle wasting, and (2) whether basal GLP-1 levels are linked to REE in HF...
  35. pmc Epigallocatechin-3-gallate: a useful, effective and safe clinical approach for targeted prevention and individualised treatment of neurological diseases?
    Anja Mähler
    Experimental and Clinical Research Center, A Joint Cooperation between the Charité University Medicine Berlin and Max Delbrueck Center for Molecular Medicine, Berlin, D 13125, Germany
    EPMA J 4:5. 2013
    ..pro-oxidative properties of the tea catechin important for dosage recommendations...
  36. ncbi request reprint mTOR and regulation of energy homeostasis in humans
    Marwan Mannaa
    Campus Virchow Klinikum, Medical Department, Division of Nephrology and Medical Intensive Care Medicine, Charite Universitatsmedizin Berlin, Augustenburger Platz 1, 13353, Berlin, Germany
    J Mol Med (Berl) 91:1167-75. 2013
    ..Specifically, clinical aspects of an impaired mTOR signaling pathway regarding the development of obesity and type-2 diabetes mellitus will be discussed. ..
  37. ncbi request reprint Water-induced thermogenesis
    Michael Boschmann
    Franz Volhard Clinical Research Center and Helios Klinikum Berlin, Medical Faculty of the Charite, Humboldt University, D 13125 Berlin, Germany
    J Clin Endocrinol Metab 88:6015-9. 2003
    ..Therefore, the thermogenic effect of water should be considered when estimating energy expenditure, particularly during weight loss programs...
  38. ncbi request reprint Tissue-specific response to interstitial angiotensin II in humans
    Michael Boschmann
    German Institute of Human Nutrition, Department of Biochemistry and Physiology of Nutrition, Potsdam, Germany
    Hypertension 41:37-41. 2003
    ..However, interstitial angiotensin II modulates lipid and carbohydrate metabolism in a tissue specific fashion. Thus, the physiology of interstitial angiotensin II cannot be predicted from intravascular studies...
  39. ncbi request reprint The adipose-tissue renin-angiotensin-aldosterone system: role in the metabolic syndrome?
    Stefan Engeli
    HELIOS Klinikum Berlin, Franz Volhard Clinic Charité, Department of Nephrology and Hypertension, Humboldt University of Berlin, Wiltberg Strasse 50, Berlin 13125, Germany
    Int J Biochem Cell Biol 35:807-25. 2003
    ....
  40. ncbi request reprint Norepinephrine transporter function and autonomic control of metabolism
    Michael Boschmann
    German Institute of Human Nutrition, 14558 Potsdam, Germany
    J Clin Endocrinol Metab 87:5130-7. 2002
    ..This effect cannot be explained by increased systemic or adipose tissue norepinephrine concentrations. Instead, NET inhibition may sensitize adipose tissue to beta-adrenergic stimulation...
  41. ncbi request reprint Gender dimorphism of body mass perception and regulation in mice
    Petra Wiedmer
    German Institute of Human Nutrition DIfE Potsdam Rehbruecke, Nuthetal, Germany
    J Exp Biol 207:2859-66. 2004
    ..Our results suggest that lean body mass rather than body mass per se seems to be tightly regulated. Higher efficiency of energy utilization in females compared to males could explain the gender-specific changes in energy balance...
  42. ncbi request reprint In vivo response to alpha(1)-adrenoreceptor stimulation in human white adipose tissue
    Michael Boschmann
    German Institute of Human Nutrition, Potsdam, Germany
    Obes Res 10:555-8. 2002
    ..Recent studies in rats suggest an important effect of alpha(1)-adrenoreceptor stimulation on glucose uptake in white adipocytes. It is not known if alpha(1)-adrenoreceptor stimulation elicits similar metabolic effects in humans...
  43. ncbi request reprint Selective norepinephrine reuptake inhibition as a human model of orthostatic intolerance
    Christoph Schroeder
    Clinical Research Center, Helios Klinkum Berlin, Germany
    Circulation 105:347-53. 2002
    ..Observations in patients with functional mutations of the norepinephrine transporter (NET) gene suggest that impaired norepinephrine uptake may contribute to idiopathic orthostatic intolerance...
  44. ncbi request reprint Effects of UVB irradiation and diclofenac on F2-isoprostane/prostaglandin concentrations in keratinocytes and microdialysates of human skin
    Ingrid Wiswedel
    J Invest Dermatol 127:1794-7. 2007