Sandra M Blois

Summary

Affiliation: Humboldt University
Country: Germany

Publications

  1. ncbi request reprint Dendritic cells: key to fetal tolerance?
    Sandra M Blois
    University Medicine of Berlin, Charite Centrum 12, Internal Medicine and Dermatology, Campus Virchow, 13353 Berlin, Germany
    Biol Reprod 77:590-8. 2007
  2. ncbi request reprint A pivotal role for galectin-1 in fetomaternal tolerance
    Sandra M Blois
    Charite, University Medicine Berlin, Biomedical Research Building, Campus Virchow, Augustenburger Platz 1, Berlin 13353, Germany
    Nat Med 13:1450-7. 2007
  3. ncbi request reprint In vivo dendritic cell depletion reduces breeding efficiency, affecting implantation and early placental development in mice
    Gesa Krey
    Charité Centrum 12 für Innere Medizin und Dermatologie, Reproductive Immunology Research Group, University Medicine of Berlin, BMFZ Raum 2 0547, CVK, Augustenburger Platz 1, 13353 Berlin, Germany
    J Mol Med (Berl) 86:999-1011. 2008
  4. doi request reprint Endometriosis research: animal models for the study of a complex disease
    Irene Tirado-Gonzalez
    Charite, Department of Internal Medicine and Dermatology, Medicine University of Berlin, Berlin, Germany
    J Reprod Immunol 86:141-7. 2010
  5. ncbi request reprint Getting too sweet: galectin-1 dysregulation in gestational diabetes mellitus
    Sandra M Blois
    Charité Center 12 Internal Medicine and Dermatology, Reproductive Medicine Research Group, Medicine University Berlin, Berlin, Germany
    Mol Hum Reprod 20:644-9. 2014
  6. pmc Uterine NK cells are critical in shaping DC immunogenic functions compatible with pregnancy progression
    Irene Tirado González
    Medicine University of Berlin, Charité Centre 12 Internal Medicine and Dermatology, Laboratory of Reproductive Medicine, Berlin, Germany
    PLoS ONE 7:e46755. 2012
  7. doi request reprint Galectin signature in normal pregnancy and preeclampsia
    Sandra M Blois
    Universitatsmedizin Berlin, Charité Center 12 Internal Medicine and Dermatology, Reproductive Medicine Research Group, Berlin, Germany Electronic address
    J Reprod Immunol 101:127-34. 2014
  8. doi request reprint Dendritic cells regulate angiogenesis associated with liver fibrogenesis
    Sandra M Blois
    Charité Center 12 Internal Medicine and Dermatology, Reproductive Medicine Research Group, Universitatsmedizin Berlin, Berlin, Germany
    Angiogenesis 17:119-28. 2014
  9. pmc Early expression of pregnancy-specific glycoprotein 22 (PSG22) by trophoblast cells modulates angiogenesis in mice
    Sandra M Blois
    Charité Centrum 12 für Innere Medizin und Dermatologie, Reproductive Medicine Research Group, University Medicine of Berlin, Berlin, Germany
    Biol Reprod 86:191. 2012
  10. doi request reprint Interaction between dendritic cells and natural killer cells during pregnancy in mice
    Sandra M Blois
    University Medicine of Berlin, Forschungshaus, Raum 2 0547, Augustenburger Platz 1, 13353, Berlin, Germany
    J Mol Med (Berl) 86:837-52. 2008

Collaborators

Detail Information

Publications24

  1. ncbi request reprint Dendritic cells: key to fetal tolerance?
    Sandra M Blois
    University Medicine of Berlin, Charite Centrum 12, Internal Medicine and Dermatology, Campus Virchow, 13353 Berlin, Germany
    Biol Reprod 77:590-8. 2007
    ..DC may also act to induce immunologic tolerance and regulation of T cell-mediated immunity. Current understanding of DC immunobiology within the context of mammalian fetal-maternal tolerance is reviewed and discussed herein...
  2. ncbi request reprint A pivotal role for galectin-1 in fetomaternal tolerance
    Sandra M Blois
    Charite, University Medicine Berlin, Biomedical Research Building, Campus Virchow, Augustenburger Platz 1, Berlin 13353, Germany
    Nat Med 13:1450-7. 2007
    ..Thus, Gal-1 is a pivotal regulator of fetomaternal tolerance that has potential therapeutic implications in threatened pregnancies...
  3. ncbi request reprint In vivo dendritic cell depletion reduces breeding efficiency, affecting implantation and early placental development in mice
    Gesa Krey
    Charité Centrum 12 für Innere Medizin und Dermatologie, Reproductive Immunology Research Group, University Medicine of Berlin, BMFZ Raum 2 0547, CVK, Augustenburger Platz 1, 13353 Berlin, Germany
    J Mol Med (Berl) 86:999-1011. 2008
    ..In view of these findings, dendritic cells emerge as possible modulators in the orchestration of events leading to the establishment and maintenance of pregnancy...
  4. doi request reprint Endometriosis research: animal models for the study of a complex disease
    Irene Tirado-Gonzalez
    Charite, Department of Internal Medicine and Dermatology, Medicine University of Berlin, Berlin, Germany
    J Reprod Immunol 86:141-7. 2010
    ....
  5. ncbi request reprint Getting too sweet: galectin-1 dysregulation in gestational diabetes mellitus
    Sandra M Blois
    Charité Center 12 Internal Medicine and Dermatology, Reproductive Medicine Research Group, Medicine University Berlin, Berlin, Germany
    Mol Hum Reprod 20:644-9. 2014
    ..Furthermore, the association between the LGALS1 polymorphism and GDM may indicate a genetic contribution to this adverse pregnancy outcome. ..
  6. pmc Uterine NK cells are critical in shaping DC immunogenic functions compatible with pregnancy progression
    Irene Tirado González
    Medicine University of Berlin, Charité Centre 12 Internal Medicine and Dermatology, Laboratory of Reproductive Medicine, Berlin, Germany
    PLoS ONE 7:e46755. 2012
    ..Thus, NK cells appear to play an important role counteracting potential anomalies raised by DC expansion and overactivity in the decidua, becoming critical for normal pregnancy progression...
  7. doi request reprint Galectin signature in normal pregnancy and preeclampsia
    Sandra M Blois
    Universitatsmedizin Berlin, Charité Center 12 Internal Medicine and Dermatology, Reproductive Medicine Research Group, Berlin, Germany Electronic address
    J Reprod Immunol 101:127-34. 2014
    ..In addition, we focus our discussion on the role of galectins in preeclampsia, a specific life-threatening pregnancy disorder. ..
  8. doi request reprint Dendritic cells regulate angiogenesis associated with liver fibrogenesis
    Sandra M Blois
    Charité Center 12 Internal Medicine and Dermatology, Reproductive Medicine Research Group, Universitatsmedizin Berlin, Berlin, Germany
    Angiogenesis 17:119-28. 2014
    ..Thus, DC emerge as novel players during the development of liver fibrosis regulating the angiogenesis process and thereby influencing fibrogenesis. ..
  9. pmc Early expression of pregnancy-specific glycoprotein 22 (PSG22) by trophoblast cells modulates angiogenesis in mice
    Sandra M Blois
    Charité Centrum 12 für Innere Medizin und Dermatologie, Reproductive Medicine Research Group, University Medicine of Berlin, Berlin, Germany
    Biol Reprod 86:191. 2012
    ..In summary, our results indicate that PSG22, the most abundant PSG expressed during mouse early pregnancy, is likely a major contributor to the establishment of a successful pregnancy...
  10. doi request reprint Interaction between dendritic cells and natural killer cells during pregnancy in mice
    Sandra M Blois
    University Medicine of Berlin, Forschungshaus, Raum 2 0547, Augustenburger Platz 1, 13353, Berlin, Germany
    J Mol Med (Berl) 86:837-52. 2008
    ..Taken together, our results provide the first evidence that a delicate balance of interactions involving NK cells, DC, and trophoblasts at the mouse maternal fetal interface supports a successful pregnancy outcome...
  11. doi request reprint Decidualization and angiogenesis in early pregnancy: unravelling the functions of DC and NK cells
    Sandra M Blois
    Charité Centrum 12 für Innere Medizin und Dermatologie, Reproductive Immunology Research Group, University Medicine of Berlin, Germany
    J Reprod Immunol 88:86-92. 2011
    ..Thus, successful implantation appears to result from an interplay between cellular components of the decidualizing endometrium involving immunoregulatory and pro-angiogenic functions of DC and NK cells...
  12. doi request reprint Neuroendocrine circuitry and endometriosis: progesterone derivative dampens corticotropin-releasing hormone-induced inflammation by peritoneal cells in vitro
    Nadja Tariverdian
    Center of Internal Medicine and Dermatology, Division of PsychoNeuroImmunology, Charite, Universitatsmedizin Berlin, Campus Virchow, Augustenburger Platz 1, Berlin, Germany
    J Mol Med (Berl) 88:267-78. 2010
    ....
  13. doi request reprint Galectin-1 influences trophoblast immune evasion and emerges as a predictive factor for the outcome of pregnancy
    Irene Tirado-Gonzalez
    Charité Center 12 Internal Medicine and Dermatology, Reproductive Medicine Research Group, Medicine University Berlin, BMFZ, Raum 2 0547, Augustenburgerplatz 1, D 13353 Berlin, Germany
    Mol Hum Reprod 19:43-53. 2013
    ..Circulating gal-1 levels could serve as a predictive factor for pregnancy success in early human gestation...
  14. ncbi request reprint High expression of survivin and down-regulation of Stat-3 characterize the feto-maternal interface in failing murine pregnancies during the implantation period
    Mariana G Garcia
    Charite, Medicine University of Berlin, Biomedical Research Building BMFZ, Raum 2 0549, Campus Virchow, Augustenburger Platz 1, 13353 Berlin, Germany
    Placenta 28:650-7. 2007
    ..The level of apoptosis was similar in the three groups studied. Our results suggest that high expression of survivin and low expression of p-Stat-3 are involved in pregnancy loss in mice...
  15. doi request reprint CXCR4(+) dendritic cells promote angiogenesis during embryo implantation in mice
    Gabriela Barrientos
    Charité Center 12 Internal Medicine and Dermatology, Reproductive Medicine Research Group, Medicine University Berlin, Berlin, Germany
    Angiogenesis 16:417-27. 2013
    ....
  16. ncbi request reprint Balanced levels of nerve growth factor are required for normal pregnancy progression
    Pierre Frank
    Laboratory of Reproductive MedicineDepartment of Psychosomatic Medicine and Psychotherapy, Charité Centre 12 Internal Medicine and Dermatology, Medicine University of Berlin, Berlin, GermanyLaboratoire d HormonologieDepartment of Gynaecology and Obstetrics, Geneva, SwitzerlandDepartment of Psychosomatic MedicinePsycho Neuro Immunology, University Giessen, Giessen, GermanyDepartment of Medical OncologyWest German Cancer Center, University Hospital Essen, University Duisburg Essen, Essen, Germany
    Reproduction 148:179-89. 2014
    ..Thus, a local threshold of NGF expression seems to be necessary to ensure maternal tolerance in healthy pregnancies, but when surpassed may result in fetal rejection due to exacerbated inflammation. ..
  17. pmc Interfering with Gal-1-mediated angiogenesis contributes to the pathogenesis of preeclampsia
    Nancy Freitag
    Charité Center 12 Internal Medicine and Dermatology, Reproductive Medicine Research Group, Universitatsmedizin Berlin, 13353 Berlin, Germany
    Proc Natl Acad Sci U S A 110:11451-6. 2013
    ..Collectively, these results strengthen the notion that Gal-1 is required for healthy gestation and highlight Gal-1 as a valuable biomarker for early PE diagnosis. ..
  18. ncbi request reprint Depletion of CD8+ cells abolishes the pregnancy protective effect of progesterone substitution with dydrogesterone in mice by altering the Th1/Th2 cytokine profile
    Sandra M Blois
    Charite, Department of Internal Medicine, Biomedizinisches Forschungszentrum, Humboldt University of Berlin, Berlin, Germany
    J Immunol 172:5893-9. 2004
    ..This pathway was exceedingly CD8-dependent, because depletion of CD8 led to a termination of the pregnancy protective effect of progesterone substitution...
  19. doi request reprint Involvement of galectin-1 in reproduction: past, present and future
    Gabriela Barrientos
    CharitéCenter 12 Internal Medicine and Dermatology, Reproductive Medicine Research Group, Universitatsmedizin Berlin, Berlin, Germany
    Hum Reprod Update 20:175-93. 2014
    ..Despite considerable advances in the understanding of the immuno- and growth-regulatory properties of gal-1 at the fetal-maternal interface, many functional aspects of this lectin in reproduction are only emerging...
  20. ncbi request reprint Prenatal stress enhances susceptibility of murine adult offspring toward airway inflammation
    Maike K Pincus-Knackstedt
    Department of Pediatrics, Division of Pneumology and Immunology, Charite, University Medicine Berlin, Germany
    J Immunol 177:8484-92. 2006
    ..This will foster the substantiation of disease-prevention strategies, such as asthma, during the prenatal period...
  21. ncbi request reprint Early risk factors for miscarriage: a prospective cohort study in pregnant women
    Petra C Arck
    Centre of Internal Medicine and Dermatology, Division of Psycho Neuro Immunology, Charite, University Medicine Berlin, Germany
    Reprod Biomed Online 17:101-13. 2008
    ....
  22. ncbi request reprint Lineage, maturity, and phenotype of uterine murine dendritic cells throughout gestation indicate a protective role in maintaining pregnancy
    Sandra M Blois
    Charite, Department of Internal Medicine, Biomedizinisches Forschungszentrum, Campus Virchow, Humboldt University of Berlin, 13353 Berlin, Germany
    Biol Reprod 70:1018-23. 2004
    ..5 to 8.5. Characterization of CD11c+ cell kinetics in uterus and blood reveals variation of phenotype during pregnancy, pointing toward an eminent immunoregulatory role of DCs throughout gestation at the feto-maternal interface...
  23. doi request reprint Administration of interferon-alpha in mice provokes peripheral and central modulation of immune cells, accompanied by behavioral effects
    Arif S Orsal
    Neuropsychiatry and Laboratory of Molecular Psychiatry, Charite Universitatsmedizin Berlin, Campus Mitte, Berlin, Germany
    Neuropsychobiology 58:211-22. 2008
    ..Unfortunately, the mechanisms underlying IFN-alpha-induced depression are still not well understood...
  24. pmc Neuroendocrine-immune disequilibrium and endometriosis: an interdisciplinary approach
    Nadja Tariverdian
    Center of Internal Medicine and Dermatology, Division of PsychoNeurolmmunology, Charite, University Medicine Berlin, Berlin, Germany
    Semin Immunopathol 29:193-210. 2007
    ..Finally, we introduce the concept of endometrial dissemination as result of a neuroendocrine-immune disequilibrium in response to high levels of perceived stress caused by cardinal clinical symptoms of endometriosis...